angiostrongylus cantonensis

Summary

Summary: A species of parasitic nematodes distributed throughout the Pacific islands that infests the lungs of domestic rats. Human infection, caused by consumption of raw slugs and land snails, results in eosinophilic meningitis.

Top Publications

  1. Thu T, Nguyen N, Lan L, Kuchle M. [Ocular angiostrongylus cantonensis in a female Vietnamese patient: case report]. Klin Monbl Augenheilkd. 2002;219:892-5 pubmed
    b>Angiostrongylus cantonensis is largely responsible for human cases of eosinophilic meningitis and meningoencephalitis in the South Pacific and South-East Asia regions. Ocular manifestations of angiostrongylus are relatively rare...
  2. Prociv P, Spratt D, Carlisle M. Neuro-angiostrongyliasis: unresolved issues. Int J Parasitol. 2000;30:1295-303 pubmed
    b>Angiostrongylus cantonensis, the rat lungworm, probably evolved with its hosts, members of the genus Rattus and closely related species, in south-east Asia...
  3. Chye S, Lin S, Chen Y, Chung L, Yen C. Immuno-PCR for detection of antigen to Angiostrongylus cantonensis circulating fifth-stage worms. Clin Chem. 2004;50:51-7 pubmed
    Definitive diagnosis of infestation with Angiostrongylus cantonensis is difficult because the parasitic nematode is undetectable in the cerebrospinal fluid (CSF) of one-half of afflicted patients and the diagnostic sensitivity of ELISA ..
  4. Eamsobhana P, Lim P, Zhang H, Gan X, Yong H. Molecular differentiation and phylogenetic relationships of three Angiostrongylus species and Angiostrongylus cantonensis geographical isolates based on a 66-kDa protein gene of A. cantonensis (Nematoda: Angiostrongylidae). Exp Parasitol. 2010;126:564-9 pubmed publisher
    ..phylogenetic relationships and molecular differentiation of three species of angiostrongylid nematodes (Angiostrongylus cantonensis, Angiostrongylus costaricensis and Angiostrongylus malaysiensis) were studied using the AC primers for ..
  5. Eamsobhana P, Wanachiwanawin D, Dechkum N, Parsartvit A, Yong H. Molecular diagnosis of eosinophilic meningitis due to Angiostrongylus cantonensis (Nematoda: Metastrongyloidea) by polymerase chain reaction-DNA sequencing of cerebrospinal fluids of patients. Mem Inst Oswaldo Cruz. 2013;108:116-8 pubmed
    Cerebrospinal fluid (CSF) samples from clinically diagnosed patients with detectable Angiostrongylus cantonensis-specific antibodies (n = 10), patients with clinically suspected cases that tested negative for A...
  6. Tokiwa T, Harunari T, Tanikawa T, Komatsu N, Koizumi N, Tung K, et al. Phylogenetic relationships of rat lungworm, Angiostrongylus cantonensis, isolated from different geographical regions revealed widespread multiple lineages. Parasitol Int. 2012;61:431-6 pubmed publisher
    ..cantonensis in each location could indicate a founder effect, which may have resulted from multiple independent origins, and suggests that haplotypes migrated from endemic areas via human-related transportation. ..
  7. Hüttemann M, Schmahl G, Mehlhorn H. Light and electron microscopic studies on two nematodes, Angiostrongylus cantonensis and Trichuris muris, differing in their mode of nutrition. Parasitol Res. 2007;101 Suppl 2:S225-32 pubmed publisher
    The morphological characteristics of the adult heteroxenous blood nematode Angiostrongylus cantonensis and the adult monoxenous intestinal nematode Trichuris muris were compared with special regard to the ultrastructure of their ..
  8. Chen K, Lee H, Lai S, Hsu L, Wang C, Liu J. Apoptosis in meningoencephalitis of Angiostrongylus cantonensis-infected mice. Exp Parasitol. 2008;119:385-90 pubmed publisher
    ..is infiltration of leukocytes into brain parenchyma and subarachnoid space infected by Angiostrongylus cantonensis. Apoptosis, a process that eliminates useless cells and counterbalances tissue homeostasis, is ..
  9. Wang J, Zheng X, Yin C, Guo Z, Qi H, Li X, et al. [Epidemiological analysis on 141 cases of angiostrongyliasis cantonensis in Beijing]. Zhonghua Liu Xing Bing Xue Za Zhi. 2008;29:27-9 pubmed

More Information

Publications100

  1. Malvy D, Ezzedine K, Receveur M, Pistone T, Crevon L, Lemardeley P, et al. Cluster of eosinophilic meningitis attributable to Angiostrongylus cantonensis infection in French policemen troop returning from the Pacific Islands. Travel Med Infect Dis. 2008;6:301-4 pubmed publisher
    ..eosinophilic meningitis are reported rarely, even in regions of endemic infestation with the roundworm Angiostrongylus cantonensis, such as the Pacific Basin. We report a cluster of eosinophilic meningitis presumably attributable to A...
  2. Hou R, Tu W, Lee H, Chen K, Chou H, Lai S. Elevation of plasminogen activators in cerebrospinal fluid of mice with eosinophilic meningitis caused by Angiostrongylus cantonensis. Int J Parasitol. 2004;34:1355-64 pubmed
    ..Infection with Angiostrongylus cantonensis in mice induced proteinase activity in parallel with the pathological changes of eosinophilic ..
  3. Panackel C, Cherian G, Vijayakumar K, Sharma R. Eosinophilic meningitis due to Angiostrongylus cantonensis. Indian J Med Microbiol. 2006;24:220-1 pubmed
    b>Angiostrongylus cantonensis is a nematode parasite that inhabits the pulmonary arteries and heart of rodents. It is one of the causative agents of fatal eosinophilic meningoencephalitis in man...
  4. Lindo J, Escoffery C, Reid B, Codrington G, Cunningham Myrie C, Eberhard M. Fatal autochthonous eosinophilic meningitis in a Jamaican child caused by Angiostrongylus cantonensis. Am J Trop Med Hyg. 2004;70:425-8 pubmed
    A fatal case of infection with Angiostrongylus cantonensis is reported in a 14-month-old Jamaican boy...
  5. Dorta Contreras A, Padilla Docal B, Moreira J, Robles L, Aroca J, Alarcon F, et al. Neuroimmunological findings of Angiostrongylus cantonensis meningitis in Ecuadorian patients. Arq Neuropsiquiatr. 2011;69:466-9 pubmed
    Meningitis caused by Angiostrongylus cantonensis has recently been reported in patients resulting from the first outbreaks in subtropical regions of Ecuador.
  6. Qvarnstrom Y, da Silva A, Teem J, Hollingsworth R, Bishop H, Graeff Teixeira C, et al. Improved molecular detection of Angiostrongylus cantonensis in mollusks and other environmental samples with a species-specific internal transcribed spacer 1-based TaqMan assay. Appl Environ Microbiol. 2010;76:5287-9 pubmed publisher
    b>Angiostrongylus cantonensis is the most common cause of human eosinophilic meningitis. Humans become infected by ingesting food items contaminated with third-stage larvae that develop in mollusks...
  7. Chotmongkol V, Sawanyawisuth K. Clinical manifestations and outcome of patients with severe eosinophilic meningoencephalitis presumably caused by Angiostrongylus cantonensis. Southeast Asian J Trop Med Public Health. 2002;33:231-4 pubmed
    ..None of them had received antihelmintic drug and seven patients were treated with corticosteroids. Ten patients died and one patient is still in a coma. Corticosteroids seem to be ineffective in severe eosinophilic meningitis. ..
  8. Morassutti A, Levert K, Pinto P, da Silva A, Wilkins P, Graeff Teixeira C. Characterization of Angiostrongylus cantonensis excretory-secretory proteins as potential diagnostic targets. Exp Parasitol. 2012;130:26-31 pubmed publisher
    ..Specifically, infections with Angiostrongylus cantonensis cause eosinophilic meningitis and Angiostrongylus costaricensis infections result in eosinophilic ..
  9. Chancellor A. A souvenir from the Pacific Islands. Pract Neurol. 2007;7:205 pubmed
  10. Lee J, Yen C. Protease secreted by the infective larvae of angiostrongylus cantonensis and its role in the penetration of mouse intestine. Am J Trop Med Hyg. 2005;72:831-6 pubmed
    The infective third-stage larvae of Angiostrongylus cantonensis secrete a proteolytic enzyme that is thought to be essential for both larval penetration into the intestinal wall of the host and full development...
  11. Tsai H, Liu Y, Kunin C, Lee S, Chen Y, Lin H, et al. Eosinophilic meningitis caused by Angiostrongylus cantonensis: report of 17 cases. Am J Med. 2001;111:109-14 pubmed
    To describe two outbreaks of Angiostrongylus cantonensis infection that occurred in Kaohsiung, Taiwan, during 1998 and 1999, and to characterize the source of the outbreaks and the clinical manifestations of the disease...
  12. Tunholi Alves V, Tunholi V, Lustrino D, Amaral L, Thiengo S, Pinheiro J. Changes in the reproductive biology of Biomphalaria glabrata experimentally infected with the nematode Angiostrongylus cantonensis. J Invertebr Pathol. 2011;108:220-3 pubmed publisher
    ..first time changes in the reproductive biology of Biomphalaria glabrata experimentally infected with Angiostrongylus cantonensis. The values of all the parameters analyzed (total number of eggs, number of egg masses, number of eggs/..
  13. Ni F, Wang Y, Zhang J, Yu L, Fang W, Luo D. Cathepsin B-like and hemoglobin-type cysteine proteases: stage-specific gene expression in Angiostrongy cantonensis. Exp Parasitol. 2012;131:433-41 pubmed publisher
    ..AC-cathB-2) and hemoglobin-type cysteine protease gene (AC-hem) were isolated and described from Angiostrongylus cantonensis adult...
  14. Hochberg N, Park S, Blackburn B, Sejvar J, Gaynor K, Chung H, et al. Distribution of eosinophilic meningitis cases attributable to Angiostrongylus cantonensis, Hawaii. Emerg Infect Dis. 2007;13:1675-80 pubmed publisher
    During November 2004-January 2005, 5 cases of eosinophilic meningitis (EM) attributable to Angiostrongylus cantonensis infection were reported in Hawaii...
  15. Wang L, Jung S, Chen C, Wong H, Wan D, Wan Y. Pathological changes in the brains of rabbits experimentally infected with Angiostrongylus cantonensis after albendazole treatment: histopathological and magnetic resonance imaging studies. J Antimicrob Chemother. 2006;57:294-300 pubmed
    To determine the effects of albendazole on rabbits infected with larvae of Angiostrongylus cantonensis by histopathological and magnetic resonance imaging (MRI) techniques. Male rabbits were infected with 400 A...
  16. Slom T, Cortese M, Gerber S, Jones R, Holtz T, Lopez A, et al. An outbreak of eosinophilic meningitis caused by Angiostrongylus cantonensis in travelers returning from the Caribbean. N Engl J Med. 2002;346:668-75 pubmed
    Outbreaks of eosinophilic meningitis caused by the roundworm Angiostrongylus cantonensis are rarely reported, even in regions of endemic infection such as Southeast Asia and the Pacific Basin. We report an outbreak of A...
  17. Wang Q, Wu Z, Wei J, Owen R, Lun Z. Human Angiostrongylus cantonensis: an update. Eur J Clin Microbiol Infect Dis. 2012;31:389-95 pubmed publisher
    b>Angiostrongylus cantonensis was first discovered in 1935 and has become an important emerging pathogen causing human angiostrongyliasis. Major outbreaks of human angiostrongyliasis have been reported in endemic regions...
  18. Tsai H, Liu Y, Kunin C, Lai P, Lee S, Chen Y, et al. Eosinophilic meningitis caused by Angiostrongylus cantonensis associated with eating raw snails: correlation of brain magnetic resonance imaging scans with clinical findings. Am J Trop Med Hyg. 2003;68:281-5 pubmed
    b>Angiostrongylus cantonensis is the most common cause of eosinophilic meningitis worldwide. Human infection occurs after ingestion of the worms in raw snails or fish that serve as intermediate hosts...
  19. Lan K, Wang C, Hsu J, Chen K, Lai S, Lee H. Induced eosinophilia and proliferation in Angiostrongylus cantonensis-infected mouse brain are associated with the induction of JAK/STAT1, IAP/NF-kappaB and MEKK1/JNK signals. J Helminthol. 2004;78:311-7 pubmed
    Eosinophilic meningitis or meningoencephalitis caused by Angiostrongylus cantonensis is endemic to the Pacific area of Asia, especially Taiwan, Thailand, and Japan. Although eosinophilia is an important clinical manifestation of A...
  20. Chikweto A, Bhaiyat M, Macpherson C, Deallie C, Pinckney R, Richards C, et al. Existence of Angiostrongylus cantonensis in rats (Rattus norvegicus) in Grenada, West Indies. Vet Parasitol. 2009;162:160-2 pubmed publisher
    The zoonotic rat lung worm, Angiostrongylus cantonensis is endemic to Asia, North America, Africa and Australia...
  21. Hsu L, Lee H, Chen K, Chou H, Lai S. Matrix metalloproteinase-2 and -9 in the granulomatous fibrosis of rats infected with Angiostrongylus cantonensis. Ann Trop Med Parasitol. 2005;99:61-70 pubmed
    ..were investigated in the brains, hearts, lungs and livers of Sprague-Dawley rats infected with Angiostrongylus cantonensis. The relationships between two gelatinases and granulomatous fibrosis were explored, following ..
  22. Podwall D, Gupta R, Furuya E, Sevigny J, Resor S. Angiostrongylus cantonensis meningitis presenting with facial nerve palsy. J Neurol. 2004;251:1280-1 pubmed
  23. Wang Q, Lai D, Zhu X, Chen X, Lun Z. Human angiostrongyliasis. Lancet Infect Dis. 2008;8:621-30 pubmed publisher
    Human angiostrongyliasis caused by Angiostrongylus cantonensis, a rat lungworm, has been reported globally...
  24. Chen M, Zhang R, Ai L, Chen J, Chen S, Huang D, et al. Seroprevalence of Angiostrongylus cantonensis infection in humans in China. J Parasitol. 2011;97:144-5 pubmed publisher
    ..was carried out in China during 2009-2010 to determine the extent of circulating antigens (CAg) for Angiostrongylus cantonensis in the Chinese population using the gold immunochromatographic assay, with the objective of elucidating ..
  25. Du W, Liao J, Fan C, Su K. Combined treatment with interleukin-12 and mebendazole lessens the severity of experimental eosinophilic meningitis caused by Angiostrongylus cantonensis in ICR mice. Infect Immun. 2003;71:3947-53 pubmed
    b>Angiostrongylus cantonensis is the major cause of eosinophilic meningoencephalitis cases in Taiwan. Mice were orally infected with 35 infective larvae...
  26. Zhang Y, Zhou X, Liu H, Lv S, Li L, Lin J, et al. [Development of PCR assay for detection of Angiostrongylus cantonensis in Pomacea canaliculata]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2006;24:353-5 pubmed
    To establish a PCR assay for detecting the third-stage larvae of Angiostrongylus cantonensis in Pomacea canaliculata...
  27. Liang S, Huang H, Pan C, Tan F. [Detection of Angiostrongylus cantonensis circulating antigen by monoclonal antibodies]. Zhonghua Yi Xue Za Zhi. 2005;85:3057-61 pubmed
    To prepare monoclonal antibodies (McAbs) against soluble antigens of adult worms of Angiostrongylus cantonensis (A. cantonensis) on the purpose to detect CAg of A. cantonensis...
  28. Chuang C, Su K, Chen C, Fan C, Lin F, Chen Y, et al. Anti-CCR3 monoclonal antibody inhibits eosinophil infiltration in Angiostrongylus cantonensis-infected ICR mice. Acta Trop. 2010;113:209-13 pubmed publisher
    ICR mice were each infected with 35 Angiostrongylus cantonensis larvae...
  29. Bärtschi E, Bordmann G, Blum J, Rothen M. Eosinophilic meningitis due to Angiostrongylus cantonensis in Switzerland. Infection. 2004;32:116-8 pubmed
    Eosinophilic meningitis is a well-known disease in areas where the rat lung worm Angiostrongylus cantonensis is endemic, i.e. in Southeast Asia and in the Caribbean...
  30. Lo Re V, Gluckman S. Eosinophilic meningitis. Am J Med. 2003;114:217-23 pubmed
    ..The most common cause is invasion of the central nervous system by helminthic parasites, particularly Angiostrongylus cantonensis, but other infections as well as noninfectious conditions may also be associated...
  31. Ouyang L, Wei J, Wu Z, Zeng X, Li Y, Jia Y, et al. Differences of larval development and pathological changes in permissive and nonpermissive rodent hosts for Angiostrongylus cantonensis infection. Parasitol Res. 2012;111:1547-57 pubmed
    b>Angiostrongylus cantonensis is a neurotrophic and pulmonary parasite which causes severe neuropathological damages by invading and developing in the central nervous system (CNS). Nonpermissive host with A...
  32. Chang S, Tang P, Wang L. A transcriptomic study on the pepsin-activated infective larvae of Angiostrongylus cantonensis. Mol Biochem Parasitol. 2011;179:47-50 pubmed publisher
    To investigate the pepsin-activated infective (third-stage) larvae of Angiostrongylus cantonensis at the transcriptomic level, 1496 ESTs were generated from a cDNA library and clustered into 161 contigs and 757 singletons...
  33. Caldeira R, Mendonca C, Goveia C, Lenzi H, Graeff Teixeira C, Lima W, et al. First record of molluscs naturally infected with Angiostrongylus cantonensis (Chen, 1935) (Nematoda: Metastrongylidae) in Brazil. Mem Inst Oswaldo Cruz. 2007;102:887-9 pubmed
    Seeking the identification of Angiostrongylus cantonensis as a potential etiological agent of three clinical cases of eosinophilic meningitis, mollusc specimens were collected in the state of Espírito Santo, Brazil...
  34. Wang Q, Chen X, Lun Z. Invasive freshwater snail, China. Emerg Infect Dis. 2007;13:1119-20 pubmed publisher
  35. Chang E, Yen C. Eosinophil chemoattracted by eotaxin from cerebrospinal fluid of mice infected with Angiostrongylus cantonensis assayed in a microchamber. Kaohsiung J Med Sci. 2004;20:209-15 pubmed
    When non-permissive hosts are infected with Angiostrongylus cantonensis, the migration of the worms to the brain and their subsequent development manifests as marked eosinophilic pleocytosis...
  36. Sawanyawisuth K, Sawanyawisuth K. Treatment of angiostrongyliasis. Trans R Soc Trop Med Hyg. 2008;102:990-6 pubmed publisher
    Angiostrongyliasis, caused by Angiostrongylus cantonensis, is endemic in northeastern Thailand and southern and eastern Taiwan and is also reported throughout the world...
  37. Padilla Docal B, Dorta Contreras A, Bu Coifiu Fanego R. [C3c activation and intrathecal biosynthesis in children suffering from eosinophilic meningoencephalitis due to Angiostrongylus cantonensis]. Rev Neurol. 2009;48:632-5 pubmed
    Eosinophilic meningoencephalitis due to Angiostrongylus cantonensis is an emergent infectious disease in our area...
  38. Li Z, Lv Z, Wei J, Liao Q, Zheng H, Wu Z. Cloning and characterization of a novel gene encoding 16 kDa protein (Ac16) from Angiostrongylus cantonensis. Parasitol Res. 2012;110:2145-53 pubmed publisher
    b>Angiostrongylus cantonensis is the most common infectious cause of eosinophilic meningitis or meningoencephalitis. A novel gene (AC16) was isolated from a cDNA library of A. cantonensis fourth-stage larvae...
  39. Lv S, Zhou X, Zhang Y, Liu H, Zhu D, Yin W, et al. The effect of temperature on the development of Angiostrongylus cantonensis (Chen 1935) in Pomacea canaliculata (Lamarck 1822). Parasitol Res. 2006;99:583-7 pubmed
    ..We studied the effects of different temperatures on the larval development of Angiostrongylus cantonensis in the freshwater snail Pomacea canaliculata...
  40. Tseng Y, Tsai H, Sy C, Lee S, Wann S, Wang Y, et al. Clinical manifestations of eosinophilic meningitis caused by Angiostrongylus cantonensis: 18 years' experience in a medical center in southern Taiwan. J Microbiol Immunol Infect. 2011;44:382-9 pubmed publisher
    With the improvement of public health, eosinophilic meningitis associated with Angiostrongylus cantonensis infection is now seldom reported in Taiwan. Eosinophilic meningitis typically occurred sporadically in children...
  41. Dorta Contreras A, Noris García E, Escobar Pérez X, Padilla Docal B. IgG1,IgG2 and IgE intrathecal synthesis in Angiostrongylus cantonensis meningoencephalitis. J Neurol Sci. 2005;238:65-70 pubmed
    b>Angiostrongylus cantonensis meningoencephalitis is an emergent zoonotic disease in the Caribbean basin, characterized by the presence of eosinophils and third stage larva of the helmint.
  42. Li Z, Sun R, Li J, Song Y, Lin Y, Zeng X, et al. Efficacy of albendazole combined with a marine fungal extract (m2-9) against Angiostrongylus cantonensis-induced meningitis in mice. J Helminthol. 2012;86:410-7 pubmed publisher
    The pathogenesis of angiostrongyliasis, resulting from Angiostrongylus cantonensis invasion of the human central nervous system, remains elusive...
  43. He H, Lv Z, Li Z, Zhang L, Liao Q, Zheng H, et al. Efficacy of combined treatment with albendazole and baicalein against eosinophilic meningitis induced by Angiostrongylus cantonensis in mice. J Helminthol. 2011;85:92-9 pubmed publisher
    b>Angiostrongylus cantonensis infection causes eosinophilic meningitis in humans. Baicalein is a flavonoid originally isolated from the roots of Scutellaria baicalensis Georgi...
  44. Deng Z, Zhang Q, Lin R, Huang S, Zhang Y, Lv S, et al. [Survey on the focus of Angiostrongylus cantonensis in Guangdong Province]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2010;28:12-6 pubmed
    To understand the distribution of Angiostrongylus cantonensis foci in Guangdong Province for making surveillance program.
  45. Lan K, Wang C, Lai S, Chen K, Lee S, Hsu J, et al. The efficacy of therapy with albendazole in mice with parasitic meningitis caused by Angiostrongylus cantonensis. Parasitol Res. 2004;93:311-7 pubmed
    ..9 (MMP-9) is involved in the pathogenesis of parasitic meningitis caused by the nematode Angiostrongylus cantonensis. The present study evaluated the efficacy of albendazole therapy in BALB/c mice infected with the third ..
  46. Luessi F, Sollors J, Torzewski M, Müller H, Siegel E, Blum J, et al. Eosinophilic meningitis due to Angiostrongylus cantonensis in Germany. J Travel Med. 2009;16:292-4 pubmed publisher
    We report a case of eosinophilic meningitis due to Angiostrongylus cantonensis in a patient who returned from Thailand...
  47. Ibrahim M. Prevalence and intensity of Angiostrongylus cantonensis in freshwater snails in relation to some ecological and biological factors. Parasite. 2007;14:61-70 pubmed
    ..In conclusion, further investigations in other areas and controlled laboratory experiments of infection approaches are required to evaluate the possible threat of this parasite on humans...
  48. Jitpimolmard S, Sawanyawisuth K, Morakote N, Vejjajiva A, Puntumetakul M, Sanchaisuriya K, et al. Albendazole therapy for eosinophilic meningitis caused by Angiostrongylus cantonensis. Parasitol Res. 2007;100:1293-6 pubmed
    Eosinophilic meningitis in humans is commonly caused by the nematode Angiostrongylus cantonensis. A severe headache is the most common presenting symptom...
  49. Intapan P, Maleewong W, Sawanyawisuth K, Chotmongkol V. Evaluation of human IgG subclass antibodies in the serodiagnosis of angiostrongyliasis. Parasitol Res. 2003;89:425-9 pubmed
    Immunoglobulin G subclass antibody (IgG1, IgG2, IgG3, and IgG4) responses to the rat lungworm, Angiostrongylus cantonensis, were analyzed using the immunoblotting technique in an attempt to further improve the sensitivity and specificity ..
  50. Yeung N, Hayes K, Cowie R. Effects of washing produce contaminated with the snail and slug hosts of Angiostrongylus cantonensis with three common household solutions. Hawaii J Med Public Health. 2013;72:83-6 pubmed
    ..rat lungworm disease) is caused by ingesting snails and slugs infected by the nematode Angiostrongylus cantonensis. The definitive hosts of A...
  51. Chen R, Tong Q, Zhang Y, Lou D, Kong Q, Lv S, et al. Loop-mediated isothermal amplification: rapid detection of Angiostrongylus cantonensis infection in Pomacea canaliculata. Parasit Vectors. 2011;4:204 pubmed publisher
    b>Angiostrongylus cantonensis is a zoonotic parasite that causes eosinophilic meningitis in humans. The most common source of infection with A. cantonensis is the consumption of raw or undercooked mollusks (e.g...
  52. Lai S, Jiang S, Chen K, Lee H. Matrix metalloproteinases activity demonstrated in the infective stage of the nematodes, Angiostrongylus cantonensis. Parasitol Res. 2005;97:466-71 pubmed
    Ingestion of the larval nematode Angiostrongylus cantonensis can cause the human eosinophilic meningitis known as angiostrongyliasis. Analysis of the extracts and excretory-secretory (ES) products of A...
  53. Li H, Xu F, Gu J, Chen X. A severe eosinophilic meningoencephalitis caused by infection of Angiostrongylus cantonensis. Am J Trop Med Hyg. 2008;79:568-70 pubmed
    This paper reports a severe case of eosinophilic meningoencephalitis after infection with Angiostrongylus cantonensis.
  54. Kumar V, Kyprianou I, Keenan J. Ocular Angiostrongyliasis: removal of a live nematode from the anterior chamber. Eye (Lond). 2005;19:229-30 pubmed
  55. Ali A, Van den Enden E, Van Gompel A, Van Esbroeck M. Eosinophilic meningitis due to Angiostrongylus cantonensis in a Belgian traveller. Travel Med Infect Dis. 2008;6:41-4 pubmed publisher
    ..The most frequent cause in travellers to the tropics is infection with the rat lungworm Angiostrongylus cantonensis. In this report, we describe a case of eosinophilic meningitis due to infection with this nematode in a ..
  56. Peng H, Sun R, Zhang Q, Zhao J, Wei J, Zeng X, et al. Interleukin 33 mediates type 2 immunity and inflammation in the central nervous system of mice infected with Angiostrongylus cantonensis. J Infect Dis. 2013;207:860-9 pubmed publisher
    b>Angiostrongylus cantonensis can induce central nervous system (CNS) injury and cause human eosinophilic meningitis...
  57. Moreira V, Giese E, Melo F, Simões R, Thiengo S, Maldonado A, et al. Endemic angiostrongyliasis in the Brazilian Amazon: natural parasitism of Angiostrongylus cantonensis in Rattus rattus and R. norvegicus, and sympatric giant African land snails, Achatina fulica. Acta Trop. 2013;125:90-7 pubmed publisher
    b>Angiostrongylus cantonensis, the rat lungworm, is one etiological agent of eosinophilic meningoencephalitis in humans...
  58. Chen X, Li H, Lun Z. Angiostrongyliasis, Mainland China. Emerg Infect Dis. 2005;11:1645-7 pubmed
  59. Leone S, De Marco M, Ghirga P, Nicastri E, Esposito M, Narciso P. Eosinophilic meningitis in a returned traveler from Santo Domingo: case report and review. J Travel Med. 2007;14:407-10 pubmed
    ..case of eosinophilic meningitis (EM) in a traveler returning from Santo Domingo, presumably caused by Angiostrongylus cantonensis. Treatment with mebendazole and steroids was effective...
  60. Jarvi S, Farias M, Howe K, Jacquier S, Hollingsworth R, PITT W. Quantitative PCR estimates Angiostrongylus cantonensis (rat lungworm) infection levels in semi-slugs (Parmarion martensi). Mol Biochem Parasitol. 2012;185:174-6 pubmed publisher
    The life cycle of the nematode Angiostrongylus cantonensis involves rats as the definitive host and slugs and snails as intermediate hosts...
  61. Chen K, Liu J, Lai S, Hsu L, Lee H. Association of plasminogen activators and matrix metalloproteinase-9 proteolytic cascade with blood-CNS barrier damage of angiostrongyliasis. Int J Exp Pathol. 2006;87:113-9 pubmed
    ..These results suggest that the PAs and MMP-9 proteolytic cascade may be associated with blood-CNS barrier disruption in eosinophilic meningitis caused by Angiostrongylus cantonensis.
  62. Lai C, Yen C, Chin C, Chung H, Kuo H, Lin H. Eosinophilic meningitis caused by Angiostrongylus cantonensis after ingestion of raw frogs. Am J Trop Med Hyg. 2007;76:399-402 pubmed
    b>Angiostrongylus cantonensis is the most common cause of eosinophilic meningitis in humans after ingestion of raw or inadequately cooked intermediate hosts or food contaminated with infective third-stage larvae...
  63. Sawanyawisuth K, Sawanyawisuth K. Drug target in eosinophilic meningitis caused by Angiostrongylus cantonensis. Infect Disord Drug Targets. 2010;10:322-8 pubmed
    Eosinophilic meningitis caused by Angiostrongylus cantonensis is an emerging infectious disease. It is the most common form of human angiostrongyliasis...
  64. Tsai H, Lee S, Huang C, Yen C, Chen E, Liu Y. Outbreak of eosinophilic meningitis associated with drinking raw vegetable juice in southern Taiwan. Am J Trop Med Hyg. 2004;71:222-6 pubmed
    The most common cause of eosinophilic meningitis is the rat lungworm Angiostrongylus cantonensis a parasite that is endemic in the southeast Asian and Pacific regions...
  65. Liu Q, Yang X, Zhang M, Wang L, Liu J, Chen J, et al. Molecular characterization and immunolocalization of a protein disulfide isomerase from Angiostrongylus cantonensis. Parasitol Res. 2012;110:2501-7 pubmed publisher
    ..of a cDNA encoding a protein disulfide isomerase (AcPDI) from a cDNA library of fourth-stage larvae of Angiostrongylus cantonensis. The deduced amino acid sequence contains two thioredoxin domains and exhibits high identity to the ..
  66. Maleewong W, Sombatsawat P, Intapan P, Wongkham C, Chotmongkol V. Immunoblot evaluation of the specificity of the 29-kDa antigen from young adult female worms Angiostrongylus cantonensis for immunodiagnosis of human angiostrongyliasis. Asian Pac J Allergy Immunol. 2001;19:267-73 pubmed
    The antigenic components of Angiostrongylus cantonensis young adult female worm somatic extract (FSE) were revealed by sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) and immunoblotting...
  67. Deng Z, Zhang Q, Huang S, Jones J. First provincial survey of Angiostrongylus cantonensis in Guangdong Province, China. Trop Med Int Health. 2012;17:119-22 pubmed publisher
    The rat lungworm Angiostrongylus cantonensis is a zoonotic nematode with a wide distribution. We report the first provincial survey of the prevalence of A. cantonensis infection among wild rodents and snails in Guangdong Province, China...
  68. Wei P, Tsai C, Chiu P, Lai S. Matrix metalloproteinase-12 leads to elastin degradation in BALB/c mice with eosinophilic meningitis caused by Angiostrongylus cantonensis. Int J Parasitol. 2011;41:1175-83 pubmed publisher
    The rat lugworm Angiostrongylus cantonensis can cause eosinophilic meningitis. The purpose of this study was to determine whether matrix metalloproteinase (MMP)-12 and its substrate elastin participate in this inflammatory response...
  69. Song Z, Huang H, Tan F, Zhang E, Hu J, Pan C. Differential proteomics analysis of female and male adults of Angiostrongylus cantonensis. Exp Parasitol. 2012;131:169-74 pubmed publisher
    In this study, we identified the differentially expressed proteins of female and male adults of Angiostrongylus cantonensis through differential proteomics...
  70. Lan K, Lai S. Differences of proteolytic enzymes and pathological changes in permissive and nonpermissive animal hosts for Angiostrongylus cantonensis infection. Vet Parasitol. 2009;165:265-72 pubmed publisher
    In this study, mice (nonpermissive hosts) infected with Angiostrongylus cantonensis showed significant worm degeneration and eosinophil degranulation, whereas infected rats (permissive hosts) showed lower worm degeneration and eosinophil ..
  71. Liu C, Song H, Zhang R, Chen M, Xu M, Ai L, et al. Specific detection of Angiostrongylus cantonensis in the snail Achatina fulica using a loop-mediated isothermal amplification (LAMP) assay. Mol Cell Probes. 2011;25:164-7 pubmed publisher
    b>Angiostrongylus cantonensis, a rat lungworm, can cause eosinophilic meningitis and angiostrongyliasis in humans following ingestion of contaminated foods or intermediate/paratenic hosts with infective larvae...
  72. Liu I, Chung Y, Chen S, Cho W. Necrotizing retinitis induced by Angiostrongylus cantonensis. Am J Ophthalmol. 2006;141:577-9 pubmed
    To describe a case of bilateral necrotizing retinitis induced by Angiostrongylus cantonensis.
  73. Morassutti A, Pinto P, Dutra B, Oliveira G, Ferreira H, Graeff Teixeira C. Detection of anti-oxidant enzymatic activities and purification of glutathione transferases from Angiostrongylus cantonensis. Exp Parasitol. 2011;127:365-9 pubmed publisher
    ..infections: Angiostrongylus costaricensis adult worms live inside the mesenteric arteries and larvae of Angiostrongylus cantonensis become trapped in the central nervous system vasculature...
  74. Tsai H, Liu Y, Lee S, Chen E, Yen C. Vascular endothelial growth factor is associated with blood brain barrier dysfunction in eosinophilic meningitis caused by Angiostrongylus cantonensis infection. Am J Trop Med Hyg. 2007;76:592-5 pubmed
    ..The VEGFSERUM fluctuated during the 6-month follow-up period. These results indicate that vascular endothelial growth factor may be associated with blood-brain barrier disruption in patients with eosinophilic meningitis...
  75. Hao L, Wu K, Chen X, Wang Q. [Cloning, prokaryotic expression and immunoreactivity evaluation of Angiostrongylus cantonensis galectin]. Nan Fang Yi Ke Da Xue Xue Bao. 2007;27:584-7 pubmed
    To construct the recombinant plasmid for Angiostrongylus cantonensis (AC) galectin (GAL) cDNA and analyze the immunological activity of the recombinant protein.
  76. Lee H, Chou H, Chen K, Lai S. Association of matrix metalloproteinase-9 in eosinophilic meningitis of BALB/c mice caused by Angiostrongylus cantonensis. Parasitol Res. 2004;94:321-8 pubmed
    Induction of gelatinase in eosinophilic meningitis of BALB/c-strain mice was caused by Angiostrongylus cantonensis. Time-course studies showed that the molecular weight of 94-kDa gelatinase was detected at day 10 post-inoculation (PI), ..
  77. Prociv P, Carlisle M. The spread of Angiostrongylus cantonensis in Australia. Southeast Asian J Trop Med Public Health. 2001;32 Suppl 2:126-8 pubmed
    Until the recent establishment of Angiostrongylus cantonensis in North America, Australia was the only developed region endemic for this parasite...
  78. Li H, Chen X, Shen H, Chen D, Qiu Y, Hu X. [Value of the antigen with molecular mass of 32 000 in immunodiagnosis of Angiostrongylus cantonensis]. Di Yi Jun Yi Da Xue Xue Bao. 2005;25:380-3 pubmed
    ..To evaluate the specificity and sensitivity of immunodiagnosis with the antigen with molecular mass of 32 000 of Angiostrongyliasis cantonensis(AC32)...
  79. Eamsobhana P, Yong H. Immunological diagnosis of human angiostrongyliasis due to Angiostrongylus cantonensis (Nematoda: Angiostrongylidae). Int J Infect Dis. 2009;13:425-31 pubmed publisher
    b>Angiostrongylus cantonensis-associated eosinophilic meningitis in humans has been commonly reported worldwide...
  80. Wang L, Yen C, Liu C, Chen E, Chao D. Effects of age and splenectomy on heavy infection of Angiostrongylus cantonensis in rats. Exp Parasitol. 2012;131:210-4 pubmed publisher
    This study was designed to determine the effects of age and the role of spleen in rats with heavy Angiostrongylus cantonensis infection...
  81. Zhang Y, Lv S, Yang K, Liu H, Hu L, Li L, et al. [The first national survey on natural nidi of Angiostrongylus cantonensis in China]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2009;27:508-12 pubmed
    To reveal the natural distribution of Angiostrongylus cantonensis in the mainland of China.
  82. Chung L, Chen C, Wang L, Chang S, Yen C. Oxidative stress in mice infected with Angiostrongylus cantonensis coincides with enhanced glutathione-dependent enzymes activity. Exp Parasitol. 2010;126:178-83 pubmed publisher
    ..of oxidative damage to protein and DNA in the cerebrospinal fluid (CSF) of C57BL/6 mice infected with Angiostrongylus cantonensis. The mean ROS concentration in the CSF of infected mice increased gradually, and the increase in ROS in ..
  83. Cheng M, Yang X, Li Z, He H, Qu Z, He A, et al. Cloning and characterization of a novel cathepsin B-like cysteine proteinase from Angiostrongylus cantonensis. Parasitol Res. 2012;110:2413-22 pubmed publisher
    ..Immunolocalization demonstrated that AcCBL1 was mainly localized in the intestine of L4. These results suggest that rAcCBL1 may play an important role in the parasite nutrition uptake...
  84. Kim D, Stewart T, Bauer R, Mitchell M. Parastrongylus (=Angiostrongylus) cantonensis now endemic in Louisiana wildlife. J Parasitol. 2002;88:1024-6 pubmed
    ..The potential of a great variety of gastropods serving as intermediate hosts in Louisiana may pose a threat to wildlife as well as to domesticated animals in the areas where infected Norway rats (Rattus norvegicus) are present...
  85. Liu Y, Han Y, Li Z, Wei J, He H, Xu C, et al. Molecular cloning and characterization of cystatin, a cysteine protease inhibitor, from Angiostrongylus cantonensis. Parasitol Res. 2010;107:915-22 pubmed publisher
    ..In the present study, a novel cystatin molecule (AcCystatin) was cloned from a cDNA library of Angiostrongylus cantonensis fourth-stage larvae...
  86. Alto W. Human infections with Angiostrongylus cantonensis. Pac Health Dialog. 2001;8:176-82 pubmed
    b>Angiostrongylus cantonensis is a parasite that causes eosinophilic meningitis and has been reported to be present on most Pacific islands. Rats are the principal host and several species of land snails the intermediate host...
  87. Chen D, Zhang Y, Shen H, Wei Y, Huang D, Tan Q, et al. Epidemiological survey of Angiostrongylus cantonensis in the west-central region of Guangdong Province, China. Parasitol Res. 2011;109:305-14 pubmed publisher
    The study was to understand the Angiostrongylus cantonensis infectious situation of rodent definitive host, snail intermediate host, and local residents in the west-central region of Guangdong Province in China...
  88. Han Y, Li Z, Li B, Sun X, Zhu C, Ling X, et al. Molecular cloning and characterization of a cathepsin B from Angiostrongylus cantonensis. Parasitol Res. 2011;109:369-78 pubmed publisher
    ..Here, we reported the cloning and characterization of a cDNA encoding a cathepsin B (AcCPB) from Angiostrongylus cantonensis fourth-stage larvae cDNA library...
  89. Dorta Contreras A, Núñez Fernandez F, Pérez Martín O, Lastre González M, Magraner Tarrau M, Bu Coifiu Fanego R, et al. [Peculiarities of meningoencephalitis caused by Angiostrongylus cantonensis in America]. Rev Neurol. 2007;45:755-63 pubmed
    25 years ago was first reported in Cuba and in the western hemisphere an emergent disease: eosinophilic meningoencephalitis due to Angiostrongylus cantonensis larvae.
  90. Zeng X, Wang J, Wei J, Wu F, Fung F, Wu X, et al. Angiostrongylus cantonensis: tegumental and hypodermic alterations of the fourth-stage larvae following administration of tribendimidine in vivo and in vitro. Parasitol Res. 2013;112:3035-40 pubmed publisher
    b>Angiostrongylus cantonensis is a parasitic pathogen whose forth-stage larvae (L4) parasitize in the central nervous system (CNS) of the human cause severe eosinophilic encephalitis or meningoencephalitis...
  91. Cowie R. Biology, systematics, life cycle, and distribution of Angiostrongylus cantonensis, the cause of rat lungworm disease. Hawaii J Med Public Health. 2013;72:6-9 pubmed
    b>Angiostrongylus cantonensis is a metastrongyloid nematode in the family Angiostrongylidae. It is the cause of angiostrongyliasis (rat lungworm disease), which manifests as eosinophilic meningitis...