nippostrongylus

Summary

Summary: A genus of intestinal nematode parasites belonging to the superfamily HELIGMOSOMATOIDEA, which commonly occurs in rats but has been experimentally transmitted to other rodents and rabbits. Infection is usually through the skin.

Top Publications

  1. Voehringer D, Shinkai K, Locksley R. Type 2 immunity reflects orchestrated recruitment of cells committed to IL-4 production. Immunity. 2004;20:267-77 pubmed
    ..IL-4-producing cell types that appear in the lungs of mice infected with the migrating intestinal helminth, Nippostrongylus brasiliensis...
  2. Soga K, Yamauchi J, Kawai Y, Yamada M, Uchikawa R, Tegoshi T, et al. Alteration of the expression profiles of acidic mucin, sialytransferase, and sulfotransferases in the intestinal epithelium of rats infected with the nematode Nippostrongylus brasiliensis. Parasitol Res. 2008;103:1427-34 pubmed publisher
    ..the alteration of acidic mucins in the jejunum of euthymic and athymic rats infected with the nematode Nippostrongylus brasiliensis using alcian blue staining and a high iron-diamine method...
  3. Dent L, Daly C, Mayrhofer G, Zimmerman T, Hallett A, Bignold L, et al. Interleukin-5 transgenic mice show enhanced resistance to primary infections with Nippostrongylus brasiliensis but not primary infections with Toxocara canis. Infect Immun. 1999;67:989-93 pubmed
    ..lifelong eosinophilia were assessed for resistance to primary infections with two tissue-invading nematodes, Nippostrongylus brasiliensis and Toxocara canis...
  4. Price A, Liang H, Sullivan B, Reinhardt R, Eisley C, Erle D, et al. Systemically dispersed innate IL-13-expressing cells in type 2 immunity. Proc Natl Acad Sci U S A. 2010;107:11489-94 pubmed publisher
    ..These cells expand robustly in response to exogenous IL-25 or IL-33 and after infection with the helminth Nippostrongylus brasiliensis, and they are the major innate IL-13-expressing cells under these conditions...
  5. Barreau F, de Lahitte J, Ferrier L, Frexinos J, Bueno L, Fioramonti J. Neonatal maternal deprivation promotes Nippostrongylus brasiliensis infection in adult rats. Brain Behav Immun. 2006;20:254-60 pubmed
    ..The present study aimed to establish whether neonatal maternal deprivation affects the time course of Nippostrongylus brasiliensis infection and associated intestinal alterations in adult rats...
  6. Ishikawa N, Horii Y, Nawa Y. Immune-mediated alteration of the terminal sugars of goblet cell mucins in the small intestine of Nippostrongylus brasiliensis-infected rats. Immunology. 1993;78:303-7 pubmed
    ..goblet cell mucins in the small intestinal mucosa was examined by lectin histochemistry in rats infected with Nippostrongylus brasiliensis...
  7. Bansemir A, Sukhdeo M. Intestinal distribution of worms and host ingesta in Nippostrongylus brasiliensis. J Parasitol. 2001;87:1470-2 pubmed
    The gastrointestinal nematode Nippostrongylus brasiliensis is thought to feed on host ingesta, and it is generally thought that the presence of ingesta determines the distribution of this parasite within the host intestine...
  8. Jones L, Houdijk J, Knox D, Kyriazakis I. Immunomodulatory effects of dietary protein during Nippostrongylus brasiliensis re-infection in lactating rats. Parasite Immunol. 2009;31:412-21 pubmed publisher
    ..The Nippostrongylus brasiliensis reinfected lactating rat model is now being utilized to investigate the immune reactions ..
  9. Mohrs M, Shinkai K, Mohrs K, Locksley R. Analysis of type 2 immunity in vivo with a bicistronic IL-4 reporter. Immunity. 2001;15:303-11 pubmed
    ..After Nippostrongylus infection, reporter expression demonstrated the evolution of type 2 immunity from tissue lymphocytes and ..

More Information

Publications93

  1. Satoh T, Takeuchi O, Vandenbon A, Yasuda K, Tanaka Y, Kumagai Y, et al. The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection. Nat Immunol. 2010;11:936-44 pubmed publisher
    ..Collectively, these results show that Jmjd3-mediated H3K27 demethylation is crucial for regulating M2 macrophage development leading to anti-helminth host responses. ..
  2. Voehringer D, Stanley S, Cox J, Completo G, Lowary T, Locksley R. Nippostrongylus brasiliensis: identification of intelectin-1 and -2 as Stat6-dependent genes expressed in lung and intestine during infection. Exp Parasitol. 2007;116:458-66 pubmed
    Elimination of the helminth parasite Nippostrongylus brasiliensis from infected mice is mediated by IL-4 or IL-13 and dependent on the IL-4Ralpha chain and the transcription factor Stat6 in non-hematopoietic cells...
  3. Sullivan B, Liang H, Bando J, WU D, Cheng L, McKerrow J, et al. Genetic analysis of basophil function in vivo. Nat Immunol. 2011;12:527-35 pubmed publisher
    ..Although targeted deletion of IL-4 and IL-13 in either CD4(+) T cells or basophils had a minimal effect on worm clearance, deletion from both lineages demonstrated a nonredundant role for basophil cytokines in primary helminth immunity...
  4. Giacomin P, Wang H, Gordon D, Botto M, Dent L. Loss of complement activation and leukocyte adherence as Nippostrongylus brasiliensis develops within the murine host. Infect Immun. 2005;73:7442-9 pubmed
    ..of this study was to determine ex vivo if complement activation by, and leukocyte adherence to, the nematode Nippostrongylus brasiliensis change as the parasite matures and migrates through the murine host...
  5. Hussein A, Kichenin K, Selkirk M. Suppression of secreted acetylcholinesterase expression in Nippostrongylus brasiliensis by RNA interference. Mol Biochem Parasitol. 2002;122:91-4 pubmed
  6. McNeil K, Knox D, Proudfoot L. Anti-inflammatory responses and oxidative stress in Nippostrongylus brasiliensis-induced pulmonary inflammation. Parasite Immunol. 2002;24:15-22 pubmed
    Migration of L3 larvae of Nippostrongylus brasiliensis through the lungs of the rat, during primary infection, was studied at 24 h, 72 h and 8 days. At 24 h p.i...
  7. Liesenfeld O, Dunay I, Erb K. Infection with Toxoplasma gondii reduces established and developing Th2 responses induced by Nippostrongylus brasiliensis infection. Infect Immun. 2004;72:3812-22 pubmed
    ..We investigated whether infection with the helminth Nippostrongylus brasiliensis influences the development of T...
  8. Fujiwara A, Kawai Y, Sekikawa S, Horii T, Yamada M, Mitsufuji S, et al. Villus epithelial injury induced by infection with the nematode Nippostrongylus brasiliensis is associated with upregulation of granzyme B. J Parasitol. 2004;90:1019-26 pubmed
    ..or ligands in athymic nude rnu/rnu rats and their littermate euthymic rnu/+ rats infected with the nematode Nippostrongylus brasiliensis...
  9. Marsland B, Camberis M, Le Gros G. Secretory products from infective forms of Nippostrongylus brasiliensis induce a rapid allergic airway inflammatory response. Immunol Cell Biol. 2005;83:40-7 pubmed
    ..The allergen, NES, is excreted and secreted from the nematode Nippostrongylus brasiliensis, and can readily be isolated from in vitro parasite cultures...
  10. Kawai Y, Yamauchi J, Soga K, Yamada M, Uchikawa R, Tegoshi T, et al. T cell-dependent and -independent expression of intestinal epithelial cell-related molecules in rats infected with the nematode Nippostrongylus brasiliensis. APMIS. 2007;115:210-7 pubmed
    ..peptide expression were examined in euthymic rnu/+ and athymic rnu/rnu rats infected with the nematode Nippostrongylus brasiliensis...
  11. Huang S, Chan D, Smyth D, Ball G, Gounaris K, Selkirk M. Activation of Nippostrongylus brasiliensis infective larvae is regulated by a pathway distinct from the hookworm Ancylostoma caninum. Int J Parasitol. 2010;40:1619-28 pubmed publisher
    ..Exposure of Nippostrongylus brasiliensis infective larvae to elevated temperature (37°C) is sufficient to activate signalling pathways ..
  12. McKenzie G, Fallon P, Emson C, Grencis R, McKenzie A. Simultaneous disruption of interleukin (IL)-4 and IL-13 defines individual roles in T helper cell type 2-mediated responses. J Exp Med. 1999;189:1565-72 pubmed
    ..IL-4/13-deficient animals are severely impaired in their ability to expel the gastrointestinal nematode Nippostrongylus brasiliensis. Unexpectedly, N...
  13. van Panhuys N, Tang S, Prout M, Camberis M, Scarlett D, Roberts J, et al. In vivo studies fail to reveal a role for IL-4 or STAT6 signaling in Th2 lymphocyte differentiation. Proc Natl Acad Sci U S A. 2008;105:12423-8 pubmed publisher
    ..contains the fluorescent reporter eGFP, were used to quantify the number of Th2 cells that develop during Nippostrongylus brasiliensis- or allergen-induced immune responses under conditions where IL-4 or STAT6 was absent...
  14. Tsubokawa D, Nakamura T, Goso Y, Takano Y, Kurihara M, Ishihara K. Nippostrongylus brasiliensis: increase of sialomucins reacting with anti-mucin monoclonal antibody HCM31 in rat small intestinal mucosa with primary infection and reinfection. Exp Parasitol. 2009;123:319-25 pubmed publisher
    Infections with the parasitic helminth, Nippostrongylus brasiliensis, cause changes in rat small intestinal goblet cell mucin, particularly in the peripheral sugar residues of oligosaccharide. These changes may correlate with expulsion...
  15. Barner M, Mohrs M, Brombacher F, Kopf M. Differences between IL-4R alpha-deficient and IL-4-deficient mice reveal a role for IL-13 in the regulation of Th2 responses. Curr Biol. 1998;8:669-72 pubmed
    ..mice deficient for IL-4 have been shown to develop residual Th2 responses [3-5] and can expel the nematode Nippostrongylus brasiliensis [6], suggesting that there is a functional equivalent of IL-4 in these processes...
  16. Seidl A, Panzer M, Voehringer D. Protective immunity against the gastrointestinal nematode Nippostrongylus brasiliensis requires a broad T-cell receptor repertoire. Immunology. 2011;134:214-23 pubmed publisher
    The parasitic gastrointestinal nematode Nippostrongylus brasiliensis induces massive expansion of T helper type 2 (Th2) cells in the lung and small intestine...
  17. Voehringer D, Reese T, Huang X, Shinkai K, Locksley R. Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system. J Exp Med. 2006;203:1435-46 pubmed
    b>Nippostrongylus brasiliensis infection and ovalbumin-induced allergic lung pathology are highly interleukin (IL)-4/IL-13 dependent, but the contributions of IL-4/IL-13 from adaptive (T helper [Th]2 cells) and innate (eosinophil, ..
  18. Pesce J, Kaviratne M, Ramalingam T, Thompson R, Urban J, Cheever A, et al. The IL-21 receptor augments Th2 effector function and alternative macrophage activation. J Clin Invest. 2006;116:2044-55 pubmed
    ..To do this, we infected IL-21R-/- mice with the Th2-inducing pathogens Schistosoma mansoni and Nippostrongylus brasiliensis and examined the influence of IL-21R deficiency on the development of Th2-dependent pathology...
  19. Shibui A, Takamoto M, Shi Y, Komiyama A, Sugane K. Cloning and characterization of a novel gene encoding keratin-like protein from nematode Nippostrongylus brasiliensis. Biochim Biophys Acta. 2001;1522:59-61 pubmed
    b>Nippostrongylus brasiliensis (Nb) is one of the most important parasites in studying Th2 immune response of the host, but little is known about its antigenic structures of the excretory-secretory or structural proteins of the parasite...
  20. Houdijk J, Jessop N, Knox D, Kyriazakis I. Secondary infection of Nippostrongylus brasiliensis in lactating rats is sensitive to dietary protein content. Br J Nutr. 2005;93:493-9 pubmed
    ..Here, we tested the hypothesis that a secondary infection with Nippostrongylus brasiliensis in lactating rats is sensitive to dietary protein content...
  21. Nair M, Gallagher I, Taylor M, Loke P, Coulson P, Wilson R, et al. Chitinase and Fizz family members are a generalized feature of nematode infection with selective upregulation of Ym1 and Fizz1 by antigen-presenting cells. Infect Immun. 2005;73:385-94 pubmed
    ..site of infection with both the tissue nematode Litomosoides sigmodontis and the gastrointestinal nematode Nippostrongylus brasiliensis. At the sites of infection with N...
  22. Kopf M, Le Gros G, Bachmann M, Lamers M, Bluethmann H, Kohler G. Disruption of the murine IL-4 gene blocks Th2 cytokine responses. Nature. 1993;362:245-8 pubmed
    ..IL-4-mutant mice (IL-4-/-) and assessed the cytokine secretion pattern of T cells both from naive and Nippostrongylus brasiliensis infected mice...
  23. Aerssens J, Hillsley K, Peeters P, de Hoogt R, Stanisz A, Lin J, et al. Alterations in the brain-gut axis underlying visceral chemosensitivity in Nippostrongylus brasiliensis-infected mice. Gastroenterology. 2007;132:1375-87 pubmed
    ..Both stress and inflammation are implicated in visceral hypersensitivity, but the underlying molecular mechanisms of visceral hypersensitivity are unknown...
  24. Ohnmacht C, Voehringer D. Basophil effector function and homeostasis during helminth infection. Blood. 2009;113:2816-25 pubmed publisher
    ..basophil development, turnover, tissue localization, and effector function during infection with the helminth Nippostrongylus brasiliensis...
  25. Farid A, Shimohira T, Kobayashi I, Sawada J, Horii Y. Intestinally implanted Nippostrongylus brasiliensis adult worms decrease serum paraoxonase-1 activity in rats. Parasitol Int. 2009;58:178-83 pubmed publisher
    We have previously reported a significant decrease in serum PON1 activity after Nippostrongylus brasiliensis infection in Wistar rats in association with the inflammatory response mounted against the parasite in the migratory phase of ..
  26. Richter S, Nieveler J, Schulze H, Bachmann T, Schmid R. High yield production of a mutant Nippostrongylus brasiliensis acetylcholinesterase in Pichia pastoris and its purification. Biotechnol Bioeng. 2006;93:1017-22 pubmed
    The mutant M301A of the acetylcholinesterase B from Nippostrongylus brasiliensis (NbAChE) was produced in a high-cell-density fermentation of a recombinant methylotrophic yeast Pichia pastoris...
  27. Morimoto M, Zhao A, Sun R, Stiltz J, Madden K, Mentink Kane M, et al. IL-13 receptor alpha2 regulates the immune and functional response to Nippostrongylus brasiliensis infection. J Immunol. 2009;183:1934-9 pubmed publisher
    IL-13 has a prominent role in host defense against the gastrointestinal nematode Nippostrongylus brasiliensis; however, the role of IL-13Ralpha2 in the immune and functional response to enteric infection is not known...
  28. Neill D, Wong S, Bellosi A, Flynn R, Daly M, Langford T, et al. Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity. Nature. 2010;464:1367-70 pubmed publisher
    ..cytokines IL25 and IL33, and represent the predominant early source of IL13 during helminth infection with Nippostrongylus brasiliensis...
  29. Harvie M, Camberis M, Tang S, Delahunt B, Paul W, Le Gros G. The lung is an important site for priming CD4 T-cell-mediated protective immunity against gastrointestinal helminth parasites. Infect Immun. 2010;78:3753-62 pubmed publisher
    The rodent hookworm Nippostrongylus brasiliensis typically infects its host by penetrating the skin and rapidly migrating to the lungs and gut...
  30. Tsubokawa D, Goso Y, Nakamura T, Maruyama H, Yatabe F, Kurihara M, et al. Rapid and specific alterations of goblet cell mucin in rat airway and small intestine associated with resistance against Nippostrongylus brasiliensis reinfection. Exp Parasitol. 2012;130:209-17 pubmed publisher
    The intestinal parasitic nematode Nippostrongylus brasiliensis is expelled rapidly from the rat in reinfection challenge compared with that of the primary infection owing to the host defense mechanisms raised against the pre-intestinal- ..
  31. Yang Z, Sullivan B, Allen C. Fluorescent in vivo detection reveals that IgE(+) B cells are restrained by an intrinsic cell fate predisposition. Immunity. 2012;36:857-72 pubmed publisher
    ..cells (PCs) during primary immune responses to a T cell-dependent hapten-protein conjugate and the helminth Nippostrongylus brasiliensis. However, the participation of IgE(+) B cells in GCs was transient...
  32. Leftwich J, Westin E, Huff T. Expression of c-kit by mesenteric lymph node cells from Nippostrongylus brasiliensis-infected mice and by mast cell colonies developing from these cells in response to 3T3 fibroblast-conditioned medium. J Immunol. 1992;148:2894-8 pubmed
    Mast cell committed progenitors are nongranulated cells found in mesenteric lymph nodes of mice infected with Nippostrongylus brasiliensis (Nb-MLN) but not from normal mice...
  33. Herbst T, Esser J, Prati M, Kulagin M, Stettler R, Zaiss M, et al. Antibodies and IL-3 support helminth-induced basophil expansion. Proc Natl Acad Sci U S A. 2012;109:14954-9 pubmed publisher
    ..helminth-induced basophil production following infection of mice with Heligmosomoides polygyrus bakeri or Nippostrongylus brasiliensis. H...
  34. Erb K, Twardzik T, Palmetshofer A, Wohlleben G, Tatsch U, Serfling E. Mice deficient in nuclear factor of activated T-cell transcription factor c2 mount increased Th2 responses after infection with Nippostrongylus brasiliensis and decreased Th1 responses after mycobacterial infection. Infect Immun. 2003;71:6641-7 pubmed
    ..of nuclear factor of activated T-cell transcription factor c2 (NFATc2)-deficient mice with the helminth Nippostrongylus brasiliensis led to a distinct increase in interleukin-4 (IL-4) and IL-5 protein synthesis by lymph node and ..
  35. Houdijk J, Jessop N, Knox D, Kyriazakis I. Breakdown of immunity to Nippostrongylus brasiliensis in lactating rats. Br J Nutr. 2003;90:809-14 pubmed
    ..We hypothesized that lactating rats would show a breakdown of immunity to Nippostrongylus brasiliensis, and that this breakdown of immunity would be sensitive to protein supply...
  36. Dainichi T, Maekawa Y, Ishii K, Zhang T, Nashed B, Sakai T, et al. Nippocystatin, a cysteine protease inhibitor from Nippostrongylus brasiliensis, inhibits antigen processing and modulates antigen-specific immune response. Infect Immun. 2001;69:7380-6 pubmed
    ..protease inhibitor, nippocystatin, derived from excretory-secretory (ES) products of an intestinal nematode, Nippostrongylus brasiliensis...
  37. Urban J, Noben Trauth N, Schopf L, Madden K, Finkelman F. Cutting edge: IL-4 receptor expression by non-bone marrow-derived cells is required to expel gastrointestinal nematode parasites. J Immunol. 2001;167:6078-81 pubmed
    Expulsion of two gastrointestinal nematode parasites, Nippostrongylus brasiliensis and Trichinella spiralis, is similar in that both require IL-4Ralpha expression, but different in that T cells and mast cells are required for IL-4-..
  38. Watanabe N, Katakura K, Kobayashi A, Okumura K, Ovary Z. Protective immunity and eosinophilia in IgE-deficient SJA/9 mice infected with Nippostrongylus brasiliensis and Trichinella spiralis. Proc Natl Acad Sci U S A. 1988;85:4460-2 pubmed
    ..responses to helminth infection, selective IgE-deficient SJA/9 mice were infected with the nematode parasites Nippostrongylus brasiliensis, which elicits remarkable potentiated IgE production, and Trichinella spiralis, which induces ..
  39. Uchikawa R, Yamada M, Matsuda S, Kuroda A, Arizono N. IgE antibody production is associated with suppressed interferon-gamma levels in mesenteric lymph nodes of rats infected with the nematode Nippostrongylus brasiliensis. Immunology. 1994;82:427-32 pubmed
    ..antibody production and interferon (IFN)-gamma secretion were studied in rats infected with the gut nematode Nippostrongylus brasiliensis by in vitro cultivation of mononuclear cells obtained from spleen (SPL), mesenteric lymph nodes (..
  40. Kasugai T, Tei H, Okada M, Hirota S, Morimoto M, Yamada M, et al. Infection with Nippostrongylus brasiliensis induces invasion of mast cell precursors from peripheral blood to small intestine. Blood. 1995;85:1334-40 pubmed
    ..changes in concentration of CFU-mast in the marrow, blood, and intestine of +/+ rats after infection with Nippostrongylus brasiliensis (NB), which induced marked mast-cell accumulation in the small intestine...
  41. Urban J, Noben Trauth N, Donaldson D, Madden K, Morris S, Collins M, et al. IL-13, IL-4Ralpha, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis. Immunity. 1998;8:255-64 pubmed
    Although IL-4 induces expulsion of the gastrointestinal nematode parasite, Nippostrongylus brasiliensis, from immunodeficient mice, this parasite is expelled normally by IL-4-deficient mice...
  42. Ramalingam T, Pesce J, Sheikh F, Cheever A, Mentink Kane M, Wilson M, et al. Unique functions of the type II interleukin 4 receptor identified in mice lacking the interleukin 13 receptor alpha1 chain. Nat Immunol. 2008;9:25-33 pubmed
    ..mice showed much less mortality after infection with Schistosoma mansoni and much more susceptibility to Nippostrongylus brasiliensis...
  43. Marsland B, Kurrer M, Reissmann R, Harris N, Kopf M. Nippostrongylus brasiliensis infection leads to the development of emphysema associated with the induction of alternatively activated macrophages. Eur J Immunol. 2008;38:479-88 pubmed publisher
    ..We show here that infection with the hookworm Nippostrongylus brasiliensis results in deterioration in lung function, destruction of alveoli and long-term airways ..
  44. Grigg M, Tang L, Hussein A, Selkirk M. Purification and properties of monomeric (G1) forms of acetylcholinesterase secreted by Nippostrongylus brasiliensis. Mol Biochem Parasitol. 1997;90:513-24 pubmed
    Acetylcholinesterase (AChE) activity secreted by Nippostrongylus brasiliensis was resolved by sucrose density centrifugation and gel permeation chromatography in single peaks estimated at 4.3 S and 60-85 kDa, respectively...
  45. Foster N, Lee D. Vasoactive intestinal polypeptide-like and peptide histidine isoleucine-like proteins excreted/secreted by Nippostrongylus brasiliensis, Nematodirus battus and Ascaridia galli. Parasitology. 1996;113 ( Pt 3):287-92 pubmed
    ..in the excretions/secretions (E/S) of Nematodirus battus and Ascaridia galli and was confirmed in the E/S of Nippostrongylus brasiliensis. ELISA analysis showed that N...
  46. Ishikawa N, Horii Y, Oinuma T, Suganuma T, Nawa Y. Goblet cell mucins as the selective barrier for the intestinal helminths: T-cell-independent alteration of goblet cell mucins by immunologically 'damaged' Nippostrongylus brasiliensis worms and its significance on the challenge infection with homolog. Immunology. 1994;81:480-6 pubmed
    ..For this purpose, Nippostrongylus brasiliensis adult worms obtained from donor rats at 7 ('normal' worms) or 13 days ('damaged' worms) post-..
  47. Liu Z, Liu Q, Pesce J, Whitmire J, Ekkens M, Foster A, et al. Nippostrongylus brasiliensis can induce B7-independent antigen-specific development of IL-4-producing T cells from naive CD4 T cells in vivo. J Immunol. 2002;169:6959-68 pubmed
    ..We have now examined the Th2 immune response to Nippostrongylus brasiliensis (Nb) in B7-1/B7-2(-/-) mice and show that Th2 effector cells develop that can mediate worm ..
  48. Zhao A, McDermott J, Urban J, Gause W, Madden K, Yeung K, et al. Dependence of IL-4, IL-13, and nematode-induced alterations in murine small intestinal smooth muscle contractility on Stat6 and enteric nerves. J Immunol. 2003;171:948-54 pubmed
    ..Separate groups of BALB/c mice were infected with Nippostrongylus brasiliensis or were drug-cured of an initial Heligmosomoides polygyrus infection and later reinfected...
  49. Holland M, Harcus Y, Balic A, Maizels R. Th2 induction by Nippostrongylus secreted antigens in mice deficient in B cells, eosinophils or MHC Class I-related receptors. Immunol Lett. 2005;96:93-101 pubmed
    ..consistent natural stimuli for Th2 responses are helminth parasites, such as the gastrointestinal nematode Nippostrongylus brasiliensis...
  50. Knott M, Matthaei K, Foster P, Dent L. The roles of eotaxin and the STAT6 signalling pathway in eosinophil recruitment and host resistance to the nematodes Nippostrongylus brasiliensis and Heligmosomoides bakeri. Mol Immunol. 2009;46:2714-22 pubmed publisher
    Expulsion of adult Nippostrongylus brasiliensis worms from the small intestine is profoundly impaired in signal transducer and activator of transcription (STAT)6-deficient mice...
  51. Farid A, Nakahara K, Murakami N, Hayashi T, Horii Y. Decreased serum paraoxonase-1 activity during intestinal nematode (Nippostrongylus brasiliensis) infection in rats. Am J Trop Med Hyg. 2008;78:770-6 pubmed
    ..conditions; however, little is known about the effects of intestinal nematode infections, such as Nippostrongylus brasiliensis, on paraoxonase activity...
  52. Hoshino K, Kashiwamura S, Kuribayashi K, Kodama T, Tsujimura T, Nakanishi K, et al. The absence of interleukin 1 receptor-related T1/ST2 does not affect T helper cell type 2 development and its effector function. J Exp Med. 1999;190:1541-8 pubmed
    ..T1/ST2(-/-) mice showed normal Th2 responses after infection with the helminthic parasite Nippostrongylus brasiliensis as well as in the mouse model of allergen-induced airway inflammation...
  53. Giacomin P, Gordon D, Botto M, Daha M, Sanderson S, Taylor S, et al. The role of complement in innate, adaptive and eosinophil-dependent immunity to the nematode Nippostrongylus brasiliensis. Mol Immunol. 2008;45:446-55 pubmed
    ..complement activation (C3-deficient) were used to assess the role of complement in immunity to the nematode Nippostrongylus brasiliensis...
  54. Knott M, Matthaei K, Giacomin P, Wang H, Foster P, Dent L. Impaired resistance in early secondary Nippostrongylus brasiliensis infections in mice with defective eosinophilopoeisis. Int J Parasitol. 2007;37:1367-78 pubmed
    ..demonstrate for the first time that defects in eosinophilopoiesis are associated with impaired resistance to Nippostrongylus brasiliensis...
  55. Yamauchi J, Kawai Y, Yamada M, Uchikawa R, Tegoshi T, Arizono N. Altered expression of goblet cell- and mucin glycosylation-related genes in the intestinal epithelium during infection with the nematode Nippostrongylus brasiliensis in rat. APMIS. 2006;114:270-8 pubmed
    ..In the present study, epithelial cells were isolated from the rat small intestine at various times after Nippostrongylus brasiliensis infection, and the levels of expression of goblet cell- and mucin glycosylation-related genes ..
  56. Miyahira Y, Akiba H, Ogawa S, Ishi T, Watanabe S, Kobayashi S, et al. Involvement of ICOS-B7RP-1 costimulatory pathway in the regulation of immune responses to Leishmania major and Nippostrongylus brasiliensis infections. Immunol Lett. 2003;89:193-9 pubmed
    ..in infection was further confirmed by infecting anti-B7RP-1 mAb-treated wild type or ICOS-deficient mice with Nippostrongylus brasiliensis. The characteristic elevation of total serum IgE and eosinophilia upon N...
  57. Liu Z, Liu Q, Hamed H, Anthony R, Foster A, Finkelman F, et al. IL-2 and autocrine IL-4 drive the in vivo development of antigen-specific Th2 T cells elicited by nematode parasites. J Immunol. 2005;174:2242-9 pubmed
    The intestinal nematode parasite, Nippostrongylus brasiliensis, triggers potent type 2 immunity...
  58. Hoeve M, Mylonas K, Fairlie Clarke K, Mahajan S, Allen J, Graham A. Plasmodium chabaudi limits early Nippostrongylus brasiliensis-induced pulmonary immune activation and Th2 polarization in co-infected mice. BMC Immunol. 2009;10:60 pubmed publisher
    ..We therefore infected BALB/c mice with the nematode Nippostrongylus brasiliensis, in the presence or absence of Plasmodium chabaudi chabaudi malaria parasites...
  59. Harcus Y, Nicoll G, Murray J, Filbey K, Gomez Escobar N, Maizels R. C-type lectins from the nematode parasites Heligmosomoides polygyrus and Nippostrongylus brasiliensis. Parasitol Int. 2009;58:461-70 pubmed publisher
    ..nematode parasites which are widely used in experimental rodent systems, Heligmosomoides polygyrus and Nippostrongylus brasiliensis...
  60. Yasuda K, Muto T, Kawagoe T, Matsumoto M, Sasaki Y, Matsushita K, et al. Contribution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematode-infected mice. Proc Natl Acad Sci U S A. 2012;109:3451-6 pubmed publisher
    ..Finally, IL-33-stimulated NH cells induce lung eosinophilic inflammation and might aid to expel infected worms in the lungs...
  61. Hussein A, Grigg M, Selkirk M. Nippostrongylus brasiliensis: characterisation of a somatic amphiphilic acetylcholinesterase with properties distinct from the secreted enzymes. Exp Parasitol. 1999;91:144-50 pubmed
    We have previously determined that Nippostrongylus brasiliensis secretes three monomeric nonamphiphilic (G1na) variants of acetylcholinesterase (AChE) with broadly similar properties...
  62. Dainichi T, Maekawa Y, Ishii K, Himeno K. Molecular cloning of a cystatin from parasitic intestinal nematode, Nippostrongylus brasiliensis. J Med Invest. 2001;48:81-7 pubmed
    ..cystatin family, nippocystatin (NbCys), was identified from excretory-secretory (ES)-products of a nematode Nippostrongylus brasiliensis, and the cDNA was cloned and sequenced...
  63. Tomita M, Kobayashi T, Itoh H, Onitsuka T, Nawa Y. Goblet cell hyperplasia in the airway of Nippostrongylus brasiliensis-infected rats. Respiration. 2000;67:565-9 pubmed
    In rats, the intestinal parasite Nippostrongylus brasiliensis is recognized as a strong inducer of intestinal goblet cell hyperplasia...
  64. Salinas Carmona M, de la Cruz Galicia G, Pérez Rivera I, Solís Soto J, Segoviano Ramirez J, Vazquez A, et al. Spontaneous arthritis in MRL/lpr mice is aggravated by Staphylococcus aureus and ameliorated by Nippostrongylus brasiliensis infections. Autoimmunity. 2009;42:25-32 pubmed publisher
    ..Infections with helminthes Heligmosomoides polygyrus, Nippostrongylus brasiliensis or bacteria Nocardia brasiliensis and Staphylococcus aureus were studied...
  65. Watanabe N, Miura K, Fukuda Y. Chymase inhibitor ameliorates eosinophilia in mice infected with Nippostrongylus brasiliensis. Int Arch Allergy Immunol. 2002;128:235-9 pubmed
    ..Infection with helminth parasites is known to increase the level of mast cell chymase in the jejunum and serum in mice. The aim of the present study is to elucidate the role of chymase in helminth infection...
  66. Pesce J, Ramalingam T, Wilson M, Mentink Kane M, Thompson R, Cheever A, et al. Retnla (relmalpha/fizz1) suppresses helminth-induced Th2-type immunity. PLoS Pathog. 2009;5:e1000393 pubmed publisher
    ..Finally, Retnla(-/-) mice infected with the gastrointestinal (GI) parasite Nippostrongylus brasiliensis had intensified lung pathology to migrating larvae, reduced fecundity, and accelerated expulsion ..
  67. Townsend J, Fallon G, Matthews J, Smith P, Jolin E, McKenzie N. IL-9-deficient mice establish fundamental roles for IL-9 in pulmonary mastocytosis and goblet cell hyperplasia but not T cell development. Immunity. 2000;13:573-83 pubmed
    ..of naive or antigen-driven antibody responses, or the expulsion of the intestinal parasitic nematode Nippostrongylus brasiliensis...
  68. Fallon P, Ballantyne S, Mangan N, Barlow J, Dasvarma A, Hewett D, et al. Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion. J Exp Med. 2006;203:1105-16 pubmed
    ..We demonstrate that il25(-/-) mice display inefficient Nippostrongylus brasiliensis expulsion and delayed cytokine production by T helper 2 cells...
  69. Inagaki Ohara K, Sakamoto Y, Dohi T, Smith A. ?? T cells play a protective role during infection with Nippostrongylus brasiliensis by promoting goblet cell function in the small intestine. Immunology. 2011;134:448-58 pubmed publisher
    ..Here, we demonstrate two major functions of ?? T cells as a potently protective T-cell population against Nippostrongylus brasiliensis infection using ?? T-cell-deficient (TCR-?(-/-) ) mice...
  70. Holmes B, Diaz Sanchez D, Lawrence R, Bell E, Maizels R, Kemeny D. The contrasting effects of CD8+ T cells on primary, established and Nippostrongylus brasiliensis-induced IgE responses. Immunology. 1996;88:252-60 pubmed
    ..to the immune response to soluble antigen, as Hooded Lister rats infected with 9000 larvae of the nematode Nippostrongylus brasiliensis produced high sustained levels of circulating IgE, in excess of 10 micrograms/ml, regardless of ..
  71. Shinkai K, Mohrs M, Locksley R. Helper T cells regulate type-2 innate immunity in vivo. Nature. 2002;420:825-9 pubmed
    ..of B and T cells, IL-4-expressing eosinophils were recruited to tissues of mice infected with the helminth Nippostrongylus brasiliensis, but eosinophils failed to degranulate...
  72. Ohnmacht C, Schwartz C, Panzer M, Schiedewitz I, Naumann R, Voehringer D. Basophils orchestrate chronic allergic dermatitis and protective immunity against helminths. Immunity. 2010;33:364-74 pubmed publisher
    ..of eosinophilia, and increase in serum IgE or IgG1 induced by allergens or by infection with the helminth Nippostrongylus brasiliensis appeared to be basophil independent...
  73. Potian J, Rafi W, Bhatt K, McBride A, Gause W, Salgame P. Preexisting helminth infection induces inhibition of innate pulmonary anti-tuberculosis defense by engaging the IL-4 receptor pathway. J Exp Med. 2011;208:1863-74 pubmed publisher
    ..We show that mice infected with the intestinal helminth Nippostrongylus brasiliensis (Nb) exhibit a transitory impairment of resistance to airborne Mtb infection...
  74. Kennedy M, McIntosh A, Blair A, McLaughlin D. MHC (RT1) restriction of the antibody repertoire to infection with the nematode Nippostrongylus brasiliensis in the rat. Immunology. 1990;71:317-22 pubmed
    ..This was modelled in inbred rats infected with the parasitic nematode Nippostrongylus brasiliensis and their responses to secreted antigens analysed by immunoprecipitation and SDS-PAGE...
  75. Chiejina S, Goyal P, Li C, Wakelin D. Concurrent infections with Trypanosoma brucei and Nippostrongylus brasiliensis in mice deficient in inducible nitric oxide. Parasitol Int. 2003;52:107-15 pubmed
    ..with Trypanosoma brucei (Tb) delays the normal protective responses of mice to the gastrointestinal parasite Nippostrongylus brasiliensis (Nb)...
  76. Wong S, Walker J, Jolin H, Drynan L, Hams E, Camelo A, et al. Transcription factor ROR? is critical for nuocyte development. Nat Immunol. 2012;13:229-36 pubmed publisher
    ..Notably, the transcription factor ROR? was critical for the development of nuocytes and their role in the expulsion of parasitic worms...
  77. Reece J, Siracusa M, Scott A. Innate immune responses to lung-stage helminth infection induce alternatively activated alveolar macrophages. Infect Immun. 2006;74:4970-81 pubmed
    While it is well established that infection with the rodent hookworm Nippostrongylus brasiliensis induces a strongly polarized Th2 immune response, little is known about the innate host-parasite interactions that lead to the development ..
  78. Pochanke V, Koller S, Dayer R, Hatak S, Ludewig B, Zinkernagel R, et al. Identification and characterization of a novel antigen from the nematode Nippostrongylus brasiliensis recognized by specific IgE. Eur J Immunol. 2007;37:1275-84 pubmed
    ..In order to identify antigens from the nematode Nippostrongylus brasiliensis, we generated an IgE-producing B cell hybridoma from N...
  79. Liu Q, Kreider T, Bowdridge S, Liu Z, Song Y, Gaydo A, et al. B cells have distinct roles in host protection against different nematode parasites. J Immunol. 2010;184:5213-23 pubmed publisher
    ..To examine this, B cell-deficient mice were inoculated with Nippostrongylus brasiliensis or Heligmosomoides polygyrus...
  80. Pesce J, Liu Z, Hamed H, Alem F, Whitmire J, Lin H, et al. Neutrophils clear bacteria associated with parasitic nematodes augmenting the development of an effective Th2-type response. J Immunol. 2008;180:464-74 pubmed
    Infection with the parasitic nematode Nippostrongylus brasiliensis induces a potent Th2 response; however, little is known about early stages of the innate response that may contribute to protective immunity...
  81. Reece J, Siracusa M, Southard T, Brayton C, Urban J, Scott A. Hookworm-induced persistent changes to the immunological environment of the lung. Infect Immun. 2008;76:3511-24 pubmed publisher
    ..Employing a rodent model of infection with hookworm (Nippostrongylus brasiliensis), we characterized the long-term changes in the immunological status of the lungs induced by ..
  82. Hussein A, Harel M, Selkirk M. A distinct family of acetylcholinesterases is secreted by Nippostrongylus brasiliensis. Mol Biochem Parasitol. 2002;123:125-34 pubmed
    A third variant of acetylcholinesterase (AChE A) secreted by the parasitic nematode Nippostrongylus brasiliensis has been isolated which shows 63-64% identity to AChE B and AChE C, with a truncated carboxyl terminus and a short internal ..
  83. Herbert D, Yang J, Hogan S, Groschwitz K, Khodoun M, Munitz A, et al. Intestinal epithelial cell secretion of RELM-beta protects against gastrointestinal worm infection. J Exp Med. 2009;206:2947-57 pubmed publisher
    ..RELM-beta is essential for normal spontaneous expulsion and IL-4-induced expulsion of Nippostrongylus brasiliensis and Heligmosomoides polygyrus, which both live in the intestinal lumen, but it does not ..
  84. Conrad D, Ben Sasson S, Le Gros G, Finkelman F, Paul W. Infection with Nippostrongylus brasiliensis or injection of anti-IgD antibodies markedly enhances Fc-receptor-mediated interleukin 4 production by non-B, non-T cells. J Exp Med. 1990;171:1497-508 pubmed
    ..Infection of mice with Nippostrongylus brasiliensis (Nb) or injection of anti-IgD antibodies, treatments known to cause striking polyclonal IgE ..