wuchereria bancrofti


Summary: A white threadlike worm which causes elephantiasis, lymphangitis, and chyluria by interfering with the lymphatic circulation. The microfilaria are found in the circulating blood and are carried by mosquitoes.

Top Publications

  1. Weil G, Ramzy R. Diagnostic tools for filariasis elimination programs. Trends Parasitol. 2007;23:78-82 pubmed
    ..This article reviews available diagnostic tests for filariasis and their potential use as tools for different phases of filariasis elimination programs...
  2. Stolk W, Swaminathan S, van Oortmarssen G, Das P, Habbema J. Prospects for elimination of bancroftian filariasis by mass drug treatment in Pondicherry, India: a simulation study. J Infect Dis. 2003;188:1371-81 pubmed
    ..In conclusion, the prospects for elimination of bancroftian filariasis by mass treatment in Pondicherry seem good, provided that the level of population coverage is sufficiently high...
  3. Kelly Hope L, Diggle P, Rowlingson B, Gyapong J, Kyelem D, Coleman M, et al. Short communication: Negative spatial association between lymphatic filariasis and malaria in West Africa. Trop Med Int Health. 2006;11:129-35 pubmed
    To determine the relationship between human lymphatic filariasis, caused by Wuchereria bancrofti, and falciparum malaria, which are co-endemic throughout West Africa...
  4. Lulitanond V, Intapan P, Pipitgool V, Choochote W, Maleewong W. Rapid detection of Wuchereria bancrofti in mosquitoes by LightCycler polymerase chain reaction and melting curve analysis. Parasitol Res. 2004;94:337-41 pubmed
    A LightCycler real-time polymerase chain reaction (PCR) assay was developed to detect Wuchereria bancrofti DNA in blood-fed mosquitoes...
  5. Helmy H, Fischer P, Farid H, Bradley M, Ramzy R. Test strip detection of Wuchereria bancrofti amplified DNA in wild-caught Culex pipiens and estimation of infection rate by a PoolScreen algorithm. Trop Med Int Health. 2004;9:158-63 pubmed
    ..Improved simple methods are needed for monitoring Wuchereria bancrofti infection in the mosquito vector and thereby the success of elimination programmes...
  6. Jaoko W, Simonsen P, Meyrowitsch D, Estambale B, Malecela Lazaro M, Michael E. Filarial-specific antibody response in East African bancroftian filariasis: effects of host infection, clinical disease, and filarial endemicity. Am J Trop Med Hyg. 2006;75:97-107 pubmed
    ..specific IgG1, IgG2, IgG3, IgG4, and IgE profiles among adults from two communities with high and low Wuchereria bancrofti endemicity...
  7. Gass K, Beau de Rochars M, Boakye D, Bradley M, Fischer P, Gyapong J, et al. A multicenter evaluation of diagnostic tools to define endpoints for programs to eliminate bancroftian filariasis. PLoS Negl Trop Dis. 2012;6:e1479 pubmed publisher
    ..Og4C3 provides a satisfactory laboratory-based diagnostic alternative. ..
  8. Beuria M, Bal M, Mandal N, Das M. Age-dependent prevalence of asymptomatic amicrofilaraemic individuals in a Wuchereria bancrofti-endemic region of India. Trans R Soc Trop Med Hyg. 2003;97:297-8 pubmed
    ..prevalence of asymptomatic amicrofilaraemics, apparently uninfected individuals, was determined in a Wuchereria bancrofti-endemic region of Orissa, India during 2001...
  9. Mehlotra R, Gray L, Blood Zikursh M, Kloos Z, Henry Halldin C, Tisch D, et al. Molecular-based assay for simultaneous detection of four Plasmodium spp. and Wuchereria bancrofti infections. Am J Trop Med Hyg. 2010;82:1030-3 pubmed publisher
    Four major malaria-causing Plasmodium spp. and lymphatic filariasis-causing Wuchereria bancrofti are co-endemic in many tropical and sub-tropical regions...

More Information

Publications125 found, 100 shown here

  1. Mand S, Debrah A, Batsa L, Adjei O, Hoerauf A. Reliable and frequent detection of adult Wuchereria bancrofti in Ghanaian women by ultrasonography. Trop Med Int Health. 2004;9:1111-4 pubmed
    Detection of adult Wuchereria bancrofti by ultrasonography of the scrotal region in men is a suitable diagnostic tool for lymphatic filariasis, whereas there are only a few case reports of adult filariae observed by ultrasonography in ..
  2. Ramesh A, Small S, Kloos Z, Kazura J, Nutman T, Serre D, et al. The complete mitochondrial genome sequence of the filarial nematode Wuchereria bancrofti from three geographic isolates provides evidence of complex demographic history. Mol Biochem Parasitol. 2012;183:32-41 pubmed publisher
    ..Here we define the complete mt genome of Wuchereria bancrofti through analysis of isolates from Papua New Guinea, India and West Africa...
  3. Michael E, Malecela Lazaro M, Simonsen P, Pedersen E, Barker G, Kumar A, et al. Mathematical modelling and the control of lymphatic filariasis. Lancet Infect Dis. 2004;4:223-34 pubmed
  4. Mishra K, Raj D, Dash A, Hazra R. Combined detection of Brugia malayi and Wuchereria bancrofti using single PCR. Acta Trop. 2005;93:233-7 pubmed
    ..PCR method has been developed for the combined detection of the human filarial parasites, Brugia malayi and Wuchereria bancrofti. Parasites' DNA were isolated from filaria positive blood samples that were collected from endemic areas...
  5. Mary K, Hoti S, Paily K. Monoclonal antibodies generated against excretory/secretory antigens of mammalian stage larvae of the lymphatic filarial parasite Wuchereria bancrofti. J Immunoassay Immunochem. 2007;28:343-57 pubmed
    Monoclonal antibodies (Mabs) against excretory/secretary (e/s) antigens of fourth stage (L4) larvae of Wuchereria bancrofti were raised and screened for their specificity and sensitivity and evaluated for their potential in detecting ..
  6. Kushwaha S, Singh P, Gupta J, Soni V, Misra Bhattacharya S. Recombinant trehalose-6-phosphate phosphatase of Brugia malayi cross-reacts with human Wuchereria bancrofti immune sera and engenders a robust protective outcome in mice. Microbes Infect. 2012;14:1330-9 pubmed publisher
    ..malayi infective larvae challenge. Taken together, our findings suggest that Bm-TPP is protective in nature and might be a potential candidate for development of vaccine against lymphatic filarial infections. ..
  7. Gbakima A, Appawu M, Dadzie S, Karikari C, Sackey S, Baffoe Wilmot A, et al. Lymphatic filariasis in Ghana: establishing the potential for an urban cycle of transmission. Trop Med Int Health. 2005;10:387-92 pubmed
    ..major urban areas (Bawku, Bolgatanga and Secondi/Takoradi), finding that the prevalence of infection with Wuchereria bancrofti ranged from 0 to 12.5%...
  8. Rao R, Atkinson L, Ramzy R, Helmy H, Farid H, Bockarie M, et al. A real-time PCR-based assay for detection of Wuchereria bancrofti DNA in blood and mosquitoes. Am J Trop Med Hyg. 2006;74:826-32 pubmed
    We developed and evaluated real-time polymerase chain reaction (PCR) assays for detecting Wuchereria bancrofti DNA in human blood and in mosquitoes. An assay based on detection of the W...
  9. Debrah A, Batsa L, Albers A, Mand S, Toliat M, Nurnberg P, et al. Transforming growth factor-?1 variant Leu10Pro is associated with both lack of microfilariae and differential microfilarial loads in the blood of persons infected with lymphatic filariasis. Hum Immunol. 2011;72:1143-8 pubmed publisher
    Antigen testing and ultrasound detection have shown that many persons are infected with Wuchereria bancrofti even though they do not have microfilariae (Mf) in the blood...
  10. Fraser M, Taleo G, Taleo F, Yaviong J, Amos M, Babu M, et al. Evaluation of the program to eliminate lymphatic filariasis in Vanuatu following two years of mass drug administration implementation: results and methodologic approach. Am J Trop Med Hyg. 2005;73:753-8 pubmed
    ..8%). Results of surveys of health workers and the community are also reported, and the methodology used for this evaluation is discussed. ..
  11. Schwab A, Churcher T, Schwab A, Basáñez M, Prichard R. An analysis of the population genetics of potential multi-drug resistance in Wuchereria bancrofti due to combination chemotherapy. Parasitology. 2007;134:1025-40 pubmed
    ..nematodes of veterinary importance, raising awareness that if anthelmintic resistance were to develop among Wuchereria bancrofti populations, this would jeopardize GPELF's goals...
  12. Harichandrakumar K, Krishnamoorthy K, Kumari A, Das L. Health status of lymphatic filariasis assessed from patients using seven domains five levels (7D5L) instrument. Acta Trop. 2006;99:137-43 pubmed
    ..The importance of these findings is discussed in view of priority setting and evaluating the morbidity management under Global Programme for Elimination of Lymphatic Filariasis (GPELF). ..
  13. Peixoto C, Santos A, Ayres C. Molecular evidence for apoptosis in microfilariae of Wuchereria bancrofti induced by diethylcarbamazine. Parasitol Res. 2008;103:717-21 pubmed publisher
    ..Here we report that diethylcarbamazine induces DNA fragmentation in microfilariae of Wuchereria bancrofti revealed by ligation-mediated polymerase chain reaction and by in situ terminal deoxynucleotidyl ..
  14. Bhumiratana A, Pechgit P, Koyadun S, Siriaut C, Yongyuth P. Imported bancroftian filariasis: diethylcarbamazine response and benzimidazole susceptibility of Wuchereria bancrofti in dynamic cross-border migrant population targeted by the National Program to Eliminate Lymphatic Filariasis in South Thailand. Acta Trop. 2010;113:121-8 pubmed publisher
    ..In particular, chain migration of cross-border Myanmar workers at risk for nocturnally periodic Wuchereria bancrofti infection can lead to imported bancroftian filariasis (IBF) in Thailand...
  15. Esterre P, Plichart C, Huin Blondey M, Nguyen L, Hartmann D, Guerret S, et al. Circulating fibrosis markers, eosinophil cationic protein and eosinophil protein X in patients with Wuchereria bancrofti infection: association with clinical status. Parasite. 2006;13:165-70 pubmed
    ..These two last markers, already validated in another helminth disease, schistosomiasis, have potential interest in terms of follow-up of morbidity in these parasitic diseases. ..
  16. Krishnamoorthy K, Subramanian S, Van Oortmarssen G, Habbema J, Das P. Vector survival and parasite infection: the effect of Wuchereria bancrofti on its vector Culex quinquefasciatus. Parasitology. 2004;129:43-50 pubmed
    ..reared Culex quinquefasciatus fed on 69 human volunteers, including 59 persons with different levels of Wuchereria bancrofti microfilariae and 10 without microfilaria. Mosquitoes were followed until death...
  17. Noroes J, Addiss D, Cedenho A, Figueredo Silva J, Lima G, Dreyer G. Pathogenesis of filarial hydrocele: risk associated with intrascrotal nodules caused by death of adult Wuchereria bancrofti. Trans R Soc Trop Med Hyg. 2003;97:561-6 pubmed
    ..is poorly understood, as is its relationship to inflammatory scrotal nodules following death of adult Wuchereria bancrofti. Between 1994 and 1998, we prospectively determined the incidence and clinical evolution of nodule-..
  18. de Kraker M, Stolk W, van Oortmarssen G, Habbema J. Model-based analysis of trial data: microfilaria and worm-productivity loss after diethylcarbamazine-albendazole or ivermectin-albendazole combination therapy against Wuchereria bancrofti. Trop Med Int Health. 2006;11:718-28 pubmed
    ..If mass treatment with these combination therapies achieves high coverage, they can have a large impact on lymphatic filariasis transmission. ..
  19. Njenga S, Wamae C, Njomo D, Mwandawiro C, Molyneux D. Chronic clinical manifestations related to Wuchereria bancrofti infection in a highly endemic area in Kenya. Trans R Soc Trop Med Hyg. 2007;101:439-44 pubmed
    ..in an effort to provide baseline data for a pilot filariasis elimination programme implemented in a Wuchereria bancrofti-endemic focus in Malindi district, Kenya. Of 186 males aged 15 years and above examined, 64 individuals (34...
  20. Nielsen N, Friis H, Magnussen P, Krarup H, Magesa S, Simonsen P. Co-infection with subclinical HIV and Wuchereria bancrofti, and the role of malaria and hookworms, in adult Tanzanians: infection intensities, CD4/CD8 counts and cytokine responses. Trans R Soc Trop Med Hyg. 2007;101:602-12 pubmed
    The association between HIV and Wuchereria bancrofti, and the role of malaria and hookworms, were analysed by comparing three groups of individuals with: (1) HIV (HIV+; n=16); (2) W...
  21. Farid H, Morsy Z, Helmy H, Ramzy R, El Setouhy M, Weil G. A critical appraisal of molecular xenomonitoring as a tool for assessing progress toward elimination of Lymphatic Filariasis. Am J Trop Med Hyg. 2007;77:593-600 pubmed
    ..1%) baseline microfilaria prevalence rates. Blood-fed Culex pipiens were pooled by household and tested for Wuchereria bancrofti DNA by PCR...
  22. Ughasi J, Bekard H, Coulibaly M, Adabie Gomez D, Gyapong J, Appawu M, et al. Mansonia africana and Mansonia uniformis are vectors in the transmission of Wuchereria bancrofti lymphatic filariasis in Ghana. Parasit Vectors. 2012;5:89 pubmed publisher
    ..melas could transmit at low level microfilaraemia. However, because An. melas is not found everywhere there was the need to determine whether any of the other culicine species could also be playing a role in the transmission of LF...
  23. Kubofcik J, Fink D, Nutman T. Identification of Wb123 as an early and specific marker of Wuchereria bancrofti infection. PLoS Negl Trop Dis. 2012;6:e1930 pubmed publisher
  24. Bonfim C, Lessa F, Oliveira C, Evangelista M, do Espírito Santo M, Meireles E, et al. [The occurrence and distribution of lymphatic filariasis in Greater Metropolitan Recife: the case of an endemic area in Jaboatão dos Guararapes, Pernambuco, Brazil]. Cad Saude Publica. 2003;19:1497-505 pubmed
    ..The results show that lymphatic filariasis is still an important public health problem in the Cavaleiro district and that it deserves attention by municipal authorities and health planners. ..
  25. Simonsen P, Magesa S. Observations on false positive reactions in the rapid NOW Filariasis card test. Trop Med Int Health. 2004;9:1200-2 pubmed
    The NOW Filariasis card test is a useful tool for rapid field diagnosis of Wuchereria bancrofti infection, based on detection of specific circulating filarial antigen (CFA) in the patients' blood...
  26. Rwegoshora R, Pedersen E, Mukoko D, Meyrowitsch D, Masese N, Malecela Lazaro M, et al. Bancroftian filariasis: patterns of vector abundance and transmission in two East African communities with different levels of endemicity. Ann Trop Med Parasitol. 2005;99:253-65 pubmed
    Intensive monitoring of Wuchereria bancrofti vector abundance and transmission intensity was carried out in two communities, one with high-level endemicity for bancroftian filariasis (Masaika, Tanzania) and the other with low-level (..
  27. Russell R, Webb C, Davies N. Aedes aegypti (L.) and Aedes polynesiensis Marks (Diptera: Culicidae) in Moorea, French Polynesia: a study of adult population structures and pathogen (Wuchereria bancrofti and Dirofilaria immitis) infection rates to indicate regional and seasonal ep. J Med Entomol. 2005;42:1045-56 pubmed
  28. Burbelo P, Ramanathan R, Klion A, Iadarola M, Nutman T. Rapid, novel, specific, high-throughput assay for diagnosis of Loa loa infection. J Clin Microbiol. 2008;46:2298-304 pubmed publisher
    ..loa, Mansonella perstans, Onchocerca volvulus, Strongyloides stercoralis, or Wuchereria bancrofti. A LIPS test measuring IgG antibody against LlSXP-1 readily differentiated L...
  29. Njenga S, Wamae C, Njomo D, Mwandawiro C, Molyneux D. Impact of two rounds of mass treatment with diethylcarbamazine plus albendazole on Wuchereria bancrofti infection and the sensitivity of immunochromatographic test in Malindi, Kenya. Trans R Soc Trop Med Hyg. 2008;102:1017-24 pubmed publisher
    ..present study indicate a relatively high effectiveness of MDA using a DEC/albendazole combination against Wuchereria bancrofti infection and, therefore, it may be a useful strategy to eliminate lymphatic filariasis in onchocerciasis-..
  30. Bockarie M, Pedersen E, White G, Michael E. Role of vector control in the global program to eliminate lymphatic filariasis. Annu Rev Entomol. 2009;54:469-87 pubmed publisher
    ..GPELF) was launched in 2000 with the principal objective of breaking the cycles of transmission of Wuchereria bancrofti and Brugia spp...
  31. Michael E, Snow L, Bockarie M. Ecological meta-analysis of density-dependent processes in the transmission of lymphatic filariasis: survival of infected vectors. J Med Entomol. 2009;46:873-80 pubmed
  32. Kyelem D, Sanou S, Boatin B, Medlock J, Coulibaly S, Molyneux D. Impact of long-term ivermectin (Mectizan) on Wuchereria bancrofti and Mansonella perstans infections in Burkina Faso: strategic and policy implications. Ann Trop Med Parasitol. 2003;97:827-38 pubmed
    ..and clinical surveys were used to determine the long-term impact of ivermectin on the prevalence of Wuchereria bancrofti and Mansonella perstans filarial infections, when the drug was given under community-directed-treatment ..
  33. Babu B, Nayak A, Dhal K. Epidemiology of episodic adenolymphangitis: a longitudinal prospective surveillance among a rural community endemic for bancroftian filariasis in coastal Orissa, India. BMC Public Health. 2005;5:50 pubmed
    ..The epidemiological knowledge on acute condition of lymphatic filariasis is essential to understand the burden and issues on management of the disease...
  34. Tisch D, Michael E, Kazura J. Mass chemotherapy options to control lymphatic filariasis: a systematic review. Lancet Infect Dis. 2005;5:514-23 pubmed
    ..literature to determine which currently available drug intervention most effectively decreases circulating Wuchereria bancrofti microfilaria in individuals and populations. 57 randomised studies of drug efficacy were identified...
  35. Coulibaly Y, Dao S, Traore A, Diallo A, Sacko M, Traore S. [Presence and risk of transmission of Wuchereria bancrofti is a reality in rural Mali: the case of the town of Bariambani in the Cirle of Kati]. Mali Med. 2006;21:12-7 pubmed
    ..This study was aimed to find Wuchereria bancrofti microfilaria in human peripheral blood and larvae in vectors...
  36. Churcher T, Schwab A, Prichard R, Basanez M. An analysis of genetic diversity and inbreeding in Wuchereria bancrofti: implications for the spread and detection of drug resistance. PLoS Negl Trop Dis. 2008;2:e211 pubmed publisher
    ..a change at position 200 of the beta-tubulin gene) in microfilariae of the lymphatic filarial parasite Wuchereria bancrofti. The presence of this genetic change has been implicated in benzimidazole resistance in parasitic nematodes ..
  37. Dixit V, Gupta A, Prasad G. Interruption of annual single dose DEC regimen administration: impact on Wuchereria bancrofti microfilaraemia, vector infection and infectivity rates. J Commun Dis. 2009;41:25-31 pubmed
    ..e; 72 mg/kg body wt (administered in 12 consecutive days) in clearing Wuchereria bancrofti microfilariae from low density micro filariae carriers (1- 8 mf per 20 microl) and its impact on vector ..
  38. Stensgaard A, Vounatsou P, Onapa A, Simonsen P, Pedersen E, Rahbek C, et al. Bayesian geostatistical modelling of malaria and lymphatic filariasis infections in Uganda: predictors of risk and geographical patterns of co-endemicity. Malar J. 2011;10:298 pubmed publisher
    In Uganda, malaria and lymphatic filariasis (causative agent Wuchereria bancrofti) are transmitted by the same vector species of Anopheles mosquitoes, and thus are likely to share common environmental risk factors and overlap in ..
  39. Peixoto C, Rocha A, Aguiar Santos A, Florêncio M. The effects of diethylcarbamazine on the ultrastructure of microfilariae of Wuchereria bancrofti in vivo and in vitro. Parasitol Res. 2004;92:513-7 pubmed
    An ultrastructural study of microfilariae of Wuchereria bancrofti was performed after treatment in vitro and in vivo with diethylcarbamazine citrate (DEC)...
  40. Farid H, Hammad R, Hassan M, Ramzy R, El Setouhy M, Weil G. Effects of combined diethylcarbamazine and albendazole treatment of bancroftian filariasis on parasite uptake and development in Culex pipiens L. Am J Trop Med Hyg. 2005;73:108-14 pubmed
    We studied effects of combined diethylcarbamazine (DEC) and albendazole (ALB) treatment on Wuchereria bancrofti microfilaria (MF) uptake and development of infective larvae (L3) in Culex pipiens...
  41. Anosike J, Nwoke B, Ajayi E, Onwuliri C, Okoro O, Oku E, et al. Lymphatic filariasis among the Ezza people of Ebonyi State, eastern Nigeria. Ann Agric Environ Med. 2005;12:181-6 pubmed
    ..This is the first time a filariasis survey due to Wuchereria bancrofti has been carried out in this state. Of the 1,243 persons examined, 210 (16.9 %) had W...
  42. Thangadurai R, Hoti S, Kumar N, Das P. Phylogeography of human lymphatic filarial parasite, Wuchereria bancrofti in India. Acta Trop. 2006;98:297-304 pubmed
    b>Wuchereria bancrofti, a nematode parasite causing human lymphatic filariasis is widely distributed in India...
  43. Dreyer G, Addiss D, Williamson J, Noroes J. Efficacy of co-administered diethylcarbamazine and albendazole against adult Wuchereria bancrofti. Trans R Soc Trop Med Hyg. 2006;100:1118-25 pubmed
    Although diethylcarbamazine (DEC) and albendazole are recommended to interrupt transmission of Wuchereria bancrofti, little is known about the macrofilaricidal effect of this drug combination. Forty-seven men with W...
  44. Jimenez M, Gonzalez L, Carranza C, Bailo B, Pérez Ayala A, Muro A, et al. Detection and discrimination of Loa loa, Mansonella perstans and Wuchereria bancrofti by PCR-RFLP and nested-PCR of ribosomal DNA ITS1 region. Exp Parasitol. 2011;127:282-6 pubmed publisher
    ..fragment length polymorphism (PCR-RFLP) protocol for the differentiation of both species from Wuchereria bancrofti, three filarial nematodes with blood circulating microfilariae...
  45. Hoerauf A, Pfarr K, Mand S, Debrah A, Specht S. Filariasis in Africa--treatment challenges and prospects. Clin Microbiol Infect. 2011;17:977-85 pubmed publisher
    ..b>Wuchereria bancrofti and Onchocerca volvulus, the species causing LF and onchocerciasis in Africa, live in mutual symbiosis with ..
  46. Rizzo J, Belo C, Lins R, Dreyer G. Children and adolescents infected with Wuchereria bancrofti in Greater Recife, Brazil: a randomized, year-long clinical trial of single treatments with diethylcarbamazine or diethylcarbamazine-albendazole. Ann Trop Med Parasitol. 2007;101:423-33 pubmed
    ..controlled trial, with a blinded evaluation of outcome, 82 children and adolescents from Recife, all with Wuchereria bancrofti microfilaraemias, were given either DEC alone (6 mg/kg) or the same dose of DEC combined with ALB (at 400 ..
  47. Tisch D, Bockarie M, Dimber Z, Kiniboro B, Tarongka N, Hazlett F, et al. Mass drug administration trial to eliminate lymphatic filariasis in Papua New Guinea: changes in microfilaremia, filarial antigen, and Bm14 antibody after cessation. Am J Trop Med Hyg. 2008;78:289-93 pubmed
    ..We evaluated changes in Wuchereria bancrofti microfilaria, filarial antigen and Bm14 antibody in individuals who participated in a five-year mass drug ..
  48. Chambers E, McClintock S, Avery M, King J, Bradley M, Schmaedick M, et al. Xenomonitoring of Wuchereria bancrofti and Dirofilaria immitis infections in mosquitoes from American Samoa: trapping considerations and a comparison of polymerase chain reaction assays with dissection. Am J Trop Med Hyg. 2009;80:774-81 pubmed
    ..The overall prevalences of Wuchereria bancrofti and Dirofilaria immitis infections in Ae. polynesiensis were, respectively, 0.16% and 1...
  49. Laney S, Ramzy R, Helmy H, Farid H, Ashour A, Weil G, et al. Detection of Wuchereria bancrofti L3 larvae in mosquitoes: a reverse transcriptase PCR assay evaluating infection and infectivity. PLoS Negl Trop Dis. 2010;4:e602 pubmed publisher
    ..We now report the development of an assay that specifically detects the infective stage of Wuchereria bancrofti in mosquitoes. The assay detects an L3-activated mRNA transcript by reverse-transcriptase PCR (RT-PCR). W...
  50. Braga C, Dourado I, Ximenes R, Miranda J, Alexander N. Bancroftian filariasis in an endemic area of Brazil: differences between genders during puberty. Rev Soc Bras Med Trop. 2005;38:224-8 pubmed
    ..The data suggest that variations between gender in filariasis could result, at least in part, from an increase in susceptibility of men. This epidemiologic feature needs to be considered while formulating elimination plans. ..
  51. Michael E, Malecela Lazaro M, Kabali C, Snow L, Kazura J. Mathematical models and lymphatic filariasis control: endpoints and optimal interventions. Trends Parasitol. 2006;22:226-33 pubmed
  52. Wattal S, Dhariwal A, Ralhan P, Tripathi V, Regu K, Kamal S, et al. Evaluation of Og4C3 antigen ELISA as a tool for detection of bancroftian filariasis under lymphatic filariasis elimination programme. J Commun Dis. 2007;39:75-84 pubmed
  53. Bal M, Beuria M, Mandal N, Das M. Antigenemia in young children living in Wuchereria bancrofti-endemic areas of Orissa, India. Trans R Soc Trop Med Hyg. 2009;103:262-5 pubmed publisher
    ..The study emphasizes the advantage of using the circulating filarial antigen assay for detecting true filarial infection and demonstrates a high prevalence of antigenemia among the 610 children studied. ..
  54. Shiferaw W, Kebede T, Graves P, Golasa L, Gebre T, Mosher A, et al. Lymphatic filariasis in western Ethiopia with special emphasis on prevalence of Wuchereria bancrofti antigenaemia in and around onchocerciasis endemic areas. Trans R Soc Trop Med Hyg. 2012;106:117-27 pubmed publisher
    ..This report summarizes initial data on the prevalence of Wuchereria bancrofti antigenaemia based on surveys carried out in a sampled population of 11685 individuals living in 125 ..
  55. Nookala S, Srinivasan S, Kaliraj P, Narayanan R, Nutman T. Impairment of tetanus-specific cellular and humoral responses following tetanus vaccination in human lymphatic filariasis. Infect Immun. 2004;72:2598-604 pubmed
    ..of the impaired parasite-specific immune response in lymphatic filariasis, the effect of concurrent Wuchereria bancrofti infection on the immune response to tetanus toxoid (TT) following tetanus vaccination was studied in 20 ..
  56. Jaoko W, Michael E, Meyrowitsch D, Estambale B, Malecela M, Simonsen P. Immunoepidemiology of Wuchereria bancrofti infection: parasite transmission intensity, filaria-specific antibodies, and host immunity in two East African communities. Infect Immun. 2007;75:5651-62 pubmed
    ..East Africa to examine the contribution of humoral responses to human immunity to the vector-borne helminth Wuchereria bancrofti. The worm intensities were higher and exhibited a nonlinear age pattern in a high-transmission community, ..
  57. Vijay Kumar K, Ramaiah K. Usage of personal-protection measures against mosquitoes and the low prevalences of Wuchereria bancrofti microfilaraemia in the Indian city of Chennai. Ann Trop Med Parasitol. 2008;102:391-7 pubmed publisher
    The usage of personal-protection measures against mosquitoes and the prevalence of Wuchereria bancrofti microfilaraemia were assessed in different areas of the city of Chennai, a large urban area in southern India...
  58. Medeiros Z, Bonfim C, Alves A, Oliveira C, Netto M, Aguiar Santos A. The epidemiological delimitation of lymphatic filariasis in an endemic area of Brazil, 41 years after the first recorded case. Ann Trop Med Parasitol. 2008;102:509-19 pubmed publisher
    ..9%. It is recommended that the National Programme to Eliminate Filariasis uses mass drug administrations and vector control throughout the district, regardless of the prevalences recorded in the latest survey...
  59. Ramaiah K, Das P, Vanamail P, Pani S. The impact of six rounds of single-dose mass administration of diethylcarbamazine or ivermectin on the transmission of Wuchereria bancrofti by Culex quinquefasciatus and its implications for lymphatic filariasis elimination programmes. Trop Med Int Health. 2003;8:1082-92 pubmed
    ..rounds of mass administration of diethylcarbamazine (DEC) or ivermectin (IVM) to interrupt transmission of Wuchereria bancrofti by Culex quinquefasciatus, the predominant parasite and vector species, respectively...
  60. Ramirez B, Hernandez L, Alberto F, Collins M, Nfonsam V, Punsalan T, et al. Contrasting Wuchereria bancrofti microfilaria rates in two Mangyan-populated Philippine villages. Am J Trop Med Hyg. 2004;71:17-23 pubmed
    Lymphatic filariasis caused by infection with Wuchereria bancrofti and Brugia malayi is endemic in 45 of 77 provinces in The Philippines...
  61. Esterre P, Plichart C, Huin Blondey M, Nguyen L. Soluble cellular adhesion molecules, selectins, VEGF and endothelin-1 in patients with Wuchereria bancrofti infection and association with clinical status. Parasite Immunol. 2005;27:9-16 pubmed
    ..endothelial adhesion and angiogenic molecules in 63 Polynesian patients living in an hyperendemic focus of Wuchereria bancrofti. Decreased serum concentrations of soluble (s-) L selectin (CD62L) were noticed in sera of of patients with ..
  62. Bisht R, Hoti S, Thangadurai R, Das P. Isolation of Wuchereria bancrofti microfilariae from archived stained blood slides for use in genetic studies and amplification of parasite and endosymbiont genes. Acta Trop. 2006;99:1-5 pubmed
    Information on change in genetic diversity of Wuchereria bancrofti is important in view of the launching of the Global Lymphatic Filariasis Elimination Programme, as it may have important consequences on the control operations and on the ..
  63. Snow L, Bockarie M, Michael E. Transmission dynamics of lymphatic filariasis: vector-specific density dependence in the development of Wuchereria bancrofti infective larvae in mosquitoes. Med Vet Entomol. 2006;20:261-72 pubmed
    The principles of meta-analysis developed in a previous study were extended to investigate the process of Wuchereria bancrofti (Cobbold) (Filarioidea: Onchocercidae) infection in mosquito (Diptera: Culicidae) hosts, focusing specifically ..
  64. Onapa A, Pedersen E, Reimert C, Simonsen P. A role for Mansonia uniformis mosquitoes in the transmission of lymphatic filariasis in Uganda?. Acta Trop. 2007;101:159-68 pubmed
    ..diurnal biting cycle, host preference and ability to support the development of experimental and natural Wuchereria bancrofti infections. Anopheles gambiae s.l. served as controls...
  65. Burbelo P, Leahy H, Iadarola M, Nutman T. A four-antigen mixture for rapid assessment of Onchocerca volvulus infection. PLoS Negl Trop Dis. 2009;3:e438 pubmed publisher
    ..We investigated whether luciferase immunoprecipitation systems (LIPS) may be used as a more rapid, specific, and standardized diagnostic assay for Onchocerca volvulus infection...
  66. Cuenco K, Ottesen E, Williams S, Nutman T, Steel C. Heritable factors play a major role in determining host responses to Wuchereria bancrofti infection in an isolated South Pacific island population. J Infect Dis. 2009;200:1271-8 pubmed publisher
    ..To test this hypothesis in bancroftian lymphatic filariasis, pedigree data were collected twice during an 18-year period from an isolated Polynesian population living on a Pacific island where lymphatic filariasis is endemic...
  67. Coulibaly Y, Dembele B, Diallo A, Lipner E, Doumbia S, Coulibaly S, et al. A randomized trial of doxycycline for Mansonella perstans infection. N Engl J Med. 2009;361:1448-58 pubmed publisher
    Mansonella perstans infection is common in areas of Africa where Wuchereria bancrofti, a causative agent of lymphatic filariasis, is endemic. M. perstans is refractory to standard antifilarial therapies...
  68. Okon O, Iboh C, Opara K. Bancroftian filariasis among the Mbembe people of Cross River state, Nigeria. J Vector Borne Dis. 2010;47:91-6 pubmed
    ..A study was undertaken to investigate the status of the disease in some rural communities of Cross River State, Nigeria, with a view to enriching the epidemiological baseline data of the disease in Nigeria...
  69. Vasuki V, Subramanian S, Hoti S, Jambulingam P. Use of a simple DNA extraction method for high-throughput detection of filarial parasite Wuchereria bancrofti in the vector mosquitoes. Parasitol Res. 2012;111:2479-81 pubmed publisher
    ..of DNA extraction developed earlier by us was employed and explored for its suitability in the detection of Wuchereria bancrofti DNA in pools of Culex quinquefasciatus mosquitoes in real-time PCR assay...
  70. Hamlin K, Moss D, Priest J, Roberts J, Kubofcik J, Gass K, et al. Longitudinal monitoring of the development of antifilarial antibodies and acquisition of Wuchereria bancrofti in a highly endemic area of Haiti. PLoS Negl Trop Dis. 2012;6:e1941 pubmed publisher
    ..Antibody responses to Wb123, a Wuchereria bancrofti L3 antigen, were measured using a Luciferase Immunoprecipitation System (LIPS) assay...
  71. Rajendran R, Sunish I, Mani T, Munirathinam A, Abdullah S, Arunachalam N, et al. Impact of two annual single-dose mass drug administrations with diethylcarbamazine alone or in combination with albendazole on Wuchereria bancrofti microfilaraemia and antigenaemia in south India. Trans R Soc Trop Med Hyg. 2004;98:174-81 pubmed
    ..8% in the 2-drug arm. Our results suggest that the annual, single-dose combination (DEC + ALB) mass treatment regimen has an enhanced effect against bancroftian filariasis compared to single-drug therapy...
  72. Plichart C, Legrand A. Detection and characterization of Wolbachia infections in Wuchereria bancrofti (Spirurida: Onchocercidae) var. pacifica and Aedes (Stegomyia) polynesiensis (Diptera: Culicidae). Am J Trop Med Hyg. 2005;73:354-8 pubmed
    ..Sequence analysis of the wsp and ftsZ genes positioned the Aedes polynesiensis Wolbachia in cluster A and Wuchereria bancrofti var. pacifica Wolbachia in cluster D...
  73. De Rochars M, Kanjilal S, Direny A, Radday J, Lafontant J, Mathieu E, et al. The Leogane, Haiti demonstration project: decreased microfilaremia and program costs after three years of mass drug administration. Am J Trop Med Hyg. 2005;73:888-94 pubmed
    ..b>Wuchereria bancrofti microfilaremia prevalence at baseline ranged from 0.8% to 15.9% in four sentinel sites...
  74. Malhotra I, Mungai P, Wamachi A, Tisch D, Kioko J, Ouma J, et al. Prenatal T cell immunity to Wuchereria bancrofti and its effect on filarial immunity and infection susceptibility during childhood. J Infect Dis. 2006;193:1005-13 pubmed
    Antenatal immune experience with Wuchereria bancrofti due to maternal filariasis may influence susceptibility to infection...
  75. Anand S, Gnanasekar M, Thangadurai M, Prabhu P, Kaliraj P, Ramaswamy K. Immune response studies with Wuchereria bancrofti vespid allergen homologue (WbVAH) in human lymphatic filariasis. Parasitol Res. 2007;101:981-8 pubmed
    A homologue of Brugia malayi venom allergen (BmVAH) was cloned from the infective stages (L3) of Wuchereria bancrofti. Sequence analysis showed 90% sequence identity between WbVAH and BmVAH...
  76. Liang J, King J, Ichimori K, Handzel T, Pa au M, Lammie P. Impact of five annual rounds of mass drug administration with diethylcarbamazine and albendazole on Wuchereria bancrofti infection in American Samoa. Am J Trop Med Hyg. 2008;78:924-8 pubmed
    ..5% of 2,989 residents were infected with Wuchereria bancrofti based on tests for circulating filarial antigen...
  77. Kishore B, Khare P, Gupta R, Bisht S. Microfilaria of Wuchereria bancrofti in cytologic smears: a report of 5 cases with unusual presentations. Acta Cytol. 2008;52:710-2 pubmed
    ..However, the disease is often overlooked or misdiagnosed because unusual presentations. As a result the patients are often subjected to numerous investigations before a definitive diagnosis is made...
  78. Veerapathran A, Dakshinamoorthy G, Gnanasekar M, Reddy M, Kalyanasundaram R. Evaluation of Wuchereria bancrofti GST as a vaccine candidate for lymphatic filariasis. PLoS Negl Trop Dis. 2009;3:e457 pubmed publisher
    ..However, vaccine potential of GSTs of lymphatic filarial parasites has not been evaluated before...
  79. Mand S, Pfarr K, Sahoo P, Satapathy A, Specht S, Klarmann U, et al. Macrofilaricidal activity and amelioration of lymphatic pathology in bancroftian filariasis after 3 weeks of doxycycline followed by single-dose diethylcarbamazine. Am J Trop Med Hyg. 2009;81:702-11 pubmed publisher
    ..dose diethylcarbamazine (administered 4 months post treatment) on depletion of Wolbachia endobacteria from Wuchereria bancrofti, filaricidal activity, and amerlioration of scrotal lymph vessel dilation were studied in 57 men from ..
  80. Kelly Hope L, Thomas B, Bockarie M, Molyneux D. Lymphatic filariasis in the Democratic Republic of Congo; micro-stratification overlap mapping (MOM) as a prerequisite for control and surveillance. Parasit Vectors. 2011;4:178 pubmed publisher
    ..Republic of Congo (DRC) has a significant burden of lymphatic filariasis (LF) caused by the parasite Wuchereria bancrofti. A major impediment to the expansion of the LF elimination programme is the risk of serious adverse events (..
  81. Pilotte N, Torres M, Tomaino F, Laney S, Williams S. A TaqMan-based multiplex real-time PCR assay for the simultaneous detection of Wuchereria bancrofti and Brugia malayi. Mol Biochem Parasitol. 2013;189:33-7 pubmed publisher
    ..This need is greatest in locations co-endemic for both Wuchereria bancrofti and Brugia parasites because testing for both causative agents individually results in significant ..
  82. Stolk W, Van Oortmarssen G, Subramanian S, Das P, Borsboom G, Habbema J, et al. Assessing density dependence in the transmission of lymphatic filariasis: uptake and development of Wuchereria bancrofti microfilariae in the vector mosquitoes. Med Vet Entomol. 2004;18:57-60 pubmed
    ..This maximum was estimated at 23 and 4 for Ae. polynesiensis and Cx. quinquefasciatus, respectively...
  83. Abe M, Yaviong J, Taleo G, Ichimori K. Microfilarial periodicity of Wuchereria bancrofti in Vanuatu. Trans R Soc Trop Med Hyg. 2003;97:498-500 pubmed
    A study on the relationship between the microfilarial periodicity of Wuchereria bancrofti and vector biting activity was carried out in Penama province, Vanuatu from February to April 1999, to enable the design of a more efficient ..
  84. Alves L, Brayner F, Silva L, Peixoto C. The ultrastructure of infective larvae (L3) of Wuchereria bancrofti after treatment with diethylcarbamazine. Micron. 2005;36:67-72 pubmed
    ..This study demonstrated that infective larvae (L3) of Wuchereria bancrofti treated in vitro with DEC presented several behaviour and morphological changes...
  85. Murty U, Praveen B, Kumar D, Sriram K, Rao K, Sai K. A baseline study of rural Bancroftian filariasis in southern India. Southeast Asian J Trop Med Public Health. 2004;35:583-6 pubmed
    ..The present study explains the trend of microfilaria dynamics in the rural population, where mass drug delivery has been implemented since 1997, and anti-larivicidal and adulticidal control measures have not been adopted...
  86. Fontes G, Braun R, Fraiha Neto H, Vieira J, Padilha S, Rocha R, et al. [Lymphatic filariasis in Belém, Pará State, North of Brazil and the perspective of elimination]. Rev Soc Bras Med Trop. 2005;38:131-6 pubmed
    ..To maintain this trend, surveillance measures must be conducted in order to detect and promptly treat patients, to prevent the risk of resurgence of a focus apparently now controlled...
  87. Taylor M, Makunde W, McGarry H, Turner J, Mand S, Hoerauf A. Macrofilaricidal activity after doxycycline treatment of Wuchereria bancrofti: a double-blind, randomised placebo-controlled trial. Lancet. 2005;365:2116-21 pubmed
    ..We used this strategy to investigate the effects of doxycycline treatment on the major cause of lymphatic filariasis, Wuchereria bancrofti.
  88. Fox L, Furness B, Haser J, Desire D, Brissau J, Milord M, et al. Tolerance and efficacy of combined diethylcarbamazine and albendazole for treatment of Wuchereria bancrofti and intestinal helminth infections in Haitian children. Am J Trop Med Hyg. 2005;73:115-21 pubmed
    ..7%) with 69.9% having more than one of these parasites. A total of 15.8% of the children had Wuchereria bancrofti microfilariae...
  89. Debrah A, Mand S, Toliat M, Marfo Debrekyei Y, Batsa L, Nurnberg P, et al. Plasma vascular endothelial growth Factor-A (VEGF-A) and VEGF-A gene polymorphism are associated with hydrocele development in lymphatic filariasis. Am J Trop Med Hyg. 2007;77:601-8 pubmed
    ..is a build-up of fluid in the scrotal regions of a proportion of men infected with the filarial nematode Wuchereria bancrofti. Vascular endothelial growth factors (VEGF) are major mediators of vascular permeability and angiogenesis ..
  90. Michael E, Malecela Lazaro M, Kazura J. Epidemiological modelling for monitoring and evaluation of lymphatic filariasis control. Adv Parasitol. 2007;65:191-237 pubmed
  91. Debrah A, Mand S, Marfo Debrekyei Y, Batsa L, Pfarr K, Buttner M, et al. Macrofilaricidal effect of 4 weeks of treatment with doxycycline on Wuchereria bancrofti. Trop Med Int Health. 2007;12:1433-41 pubmed
    To evaluate the efficacy of doxycycline as a macrofilaricidal agent against Wuchereria bancrofti.
  92. Boakye D, Wilson M, Appawu M, Gyapong J. Vector competence, for Wuchereria bancrofti, of the Anopheles populations in the Bongo district of Ghana. Ann Trop Med Parasitol. 2004;98:501-8 pubmed
    The ability of vector mosquitoes to transmit the microfilariae (mff) of Wuchereria bancrofti, especially when the levels of microfilaraemia in the humans on which the mosquitoes are feeding are very low, is very important for ..