brugia pahangi

Summary

Summary: A species of parasitic nematode found in man and other mammals. It has been reported from Malaya and East Pakistan and may produce symptoms of tropical eosinophilia.

Top Publications

  1. Gunawardena N, Fujimaki Y, Aoki Y, Mishima N, Ezaki T, Uni S, et al. Differential effects of diethylcarbamazine, tetracycline and the combination on Brugia pahangi adult females in vitro. Parasitol Int. 2005;54:253-9 pubmed
    Anti-filarial effects of diethylcarbamazine (DEC), tetracycline (TC) and the combination on Brugia pahangi adult females were studied in 7-day cell-free culture, in terms of microfilaria release, parasite motility, MTT assay for parasite ..
  2. Chirgwin S, Coleman S, Porthouse K, Klei T. Tissue migration capability of larval and adult Brugia pahangi. J Parasitol. 2006;92:46-51 pubmed
    ..Mature (45 day) adult B. pahangi displayed little migration away from the SC infection site, suggesting tissue migration may be limited to developing stages of the parasite...
  3. Chirgwin S, Coleman S, Klei T. Brugia pahangi: in vivo tissue migration of early L3 alters gene expression. Exp Parasitol. 2008;118:89-95 pubmed
    ..b>Brugia pahangi larvae injected intradermal (ID) into the hind limb of the gerbil (Meriones unguiculatus) can be recovered ..
  4. Taldone T, Gillan V, Sun W, Rodina A, Patel P, Maitland K, et al. Assay strategies for the discovery and validation of therapeutics targeting Brugia pahangi Hsp90. PLoS Negl Trop Dis. 2010;4:e714 pubmed publisher
    ..The assay is suitable for high-throughput screening and provides the first example of a format with the potential to identify novel inhibitors of Hsp90 in filarial worms and in other parasitic species where Hsp90 may be a target...
  5. Gillan V, Lawrence R, Devaney E. B cells play a regulatory role in mice infected with the L3 of Brugia pahangi. Int Immunol. 2005;17:373-82 pubmed
    Mice infected with the L3 of the filarial nematode Brugia pahangi make a strong T(h)2 response characterized by elevated levels of antigen-specific IL-4, IL-5 and IL-10...
  6. Gillan V, Devaney E. Regulatory T cells modulate Th2 responses induced by Brugia pahangi third-stage larvae. Infect Immun. 2005;73:4034-42 pubmed
    Infection of BALB/c mice with Brugia pahangi third-stage larvae (L3) results in the production of interleukin-4 (IL-4), IL-5, and IL-10 with a resultant down-regulation in Th1 responses...
  7. Chirgwin S, Rao U, Mai Z, Coleman S, Nowling J, Klei T. Kinetics of T cell cytokine gene expression in gerbils after a primary subcutaneous Brugia pahangi infection. J Parasitol. 2005;91:264-8 pubmed
    ..IL-13, and interferon (IFN)-gamma messenger RNA (mRNA) in gerbils after a primary subcutaneous infection with Brugia pahangi. Chronically infected gerbils showed elevated IL-4 in all tissues, compared with earlier time points, linking ..
  8. Ramalingam T, Rajan B, Lee J, Rajan T. Kinetics of cellular responses to intraperitoneal Brugia pahangi infections in normal and immunodeficient mice. Infect Immun. 2003;71:4361-7 pubmed
    ..and determine the kinetics of accumulation of each of the different cell types following infection with Brugia pahangi. We find that (i) four-color flow-cytometric analysis of peritoneal exudate cells using anti-CD3, -CD11b, -..
  9. Kusaba T, Fujimaki Y, Vincent A, Aoki Y. In vitro chemotaxis of Brugia pahangi infective larvae to the sera and hemolymph of mammals and lower animals. Parasitol Int. 2008;57:179-84 pubmed publisher
    The jird (Mongolian gerbil) is a highly susceptible experimental host for the lymphatic filarial nematode, Brugia pahangi. The chemotactic activity of serum from this host for B...

More Information

Publications94

  1. Fong M, Asha T, Azdayanti M, Yee L, Sinnadurai S, Rohela M. Inferring the phylogenetic position of Brugia pahangi using 18S ribosomal RNA (18S rRNA) gene sequence. Trop Biomed. 2008;25:87-92 pubmed
    This paper presents the first reported use of 18S rRNA gene sequence to determine the phylogeny of Brugia pahangi. The 18S rRNA nucleotide sequence of a Malaysian B. pahangi isolate was obtained by PCR cloning and sequencing...
  2. Zipperer G, Arumugam S, Chirgwin S, Coleman S, Shakya K, Klei T. Brugia pahangi: immunization with early L3 ES alters parasite migration, and reduces microfilaremia and lymphatic lesion formation in gerbils (Meriones unguiculatus). Exp Parasitol. 2013;135:446-55 pubmed publisher
    Previous studies have shown that intradermally (ID) injected Brugia pahangi L3 s migrate through various tissues and into the lymphatics of gerbils in a distinct pattern...
  3. Kambris Z, Cook P, Phuc H, Sinkins S. Immune activation by life-shortening Wolbachia and reduced filarial competence in mosquitoes. Science. 2009;326:134-6 pubmed publisher
    ..The cost of constitutive immune up-regulation may contribute to the life-shortening phenotype...
  4. Areekit S, Kanjanavas P, Pakpitchareon A, Khawsak P, Khuchareontaworn S, Sriyaphai T, et al. High resolution melting real-time PCR for rapid discrimination between Brugia malayi and Brugia pahangi. J Med Assoc Thai. 2009;92 Suppl 3:S24-8 pubmed
    ..To identify two closely related Brugia malayi and B. pahangi in cat reservoirs by using high resolution melting real-time PCR (HRM real-time PCR)...
  5. Andrews E, Crain P, Fu Y, Howe D, Dobson S. Reactive oxygen species production and Brugia pahangi survivorship in Aedes polynesiensis with artificial Wolbachia infection types. PLoS Pathog. 2012;8:e1003075 pubmed publisher
    ..Following a challenge with Brugia pahangi, the number of filarial worms achieving the infective stage is significantly reduced in MTB as compared to the ..
  6. Chirgwin S, Nowling J, Coleman S, Klei T. Brugia pahangi and Wolbachia: the kinetics of bacteria elimination, worm viability, and host responses following tetracycline treatment. Exp Parasitol. 2003;103:16-26 pubmed
    ..Tetracycline treatment of L4 or adult Brugia pahangi in vivo resulted in Wolbachia clearance...
  7. Gunawardena N, Fujimaki Y, Aoki Y. Chemotactic response of Brugia pahangi infective larvae to jird serum in vitro. Parasitol Res. 2003;90:337-42 pubmed
    The Brugia pahangi infective larval response to jird serum was studied using an agar plate assay. Larvae placed onto the agar remained at the same place for 60 min...
  8. Ramalingam T, Porte P, Lee J, Rajan T. Eosinophils, but not eosinophil peroxidase or major basic protein, are important for host protection in experimental Brugia pahangi infection. Infect Immun. 2005;73:8442-3 pubmed
    ..to CCR3 consistently correlates with impairment in worm elimination following primary intraperitoneal Brugia pahangi infections in mice...
  9. Chirgwin S, Rao U, Coleman S, Nowling J, Klei T. Profiling the cellular immune response to multiple Brugia pahangi infections in a susceptible host. J Parasitol. 2005;91:822-9 pubmed
    ..pahangi. Chronic infections were also associated with a state of immune hyporesponsiveness, as determined by the characterization of lymphatic thrombi and lymphoproliferation of spleen and renal lymph node cells to worm antigen...
  10. Junhom W, Chungpivat S, Viseshakul N. The observation of microfilarial rate and density in cats inoculated with increasing numbers of Brugia pahangi infective larvae. Southeast Asian J Trop Med Public Health. 2006;37 Suppl 3:40-2 pubmed
    ..05) from cats with 300 and 100 L3. However, we concluded that the amount of microfilariae produced in the blood circulation of these cats were not increasing relative to the numbers of L3 taken by the host...
  11. Aliota M, Fuchs J, Mayhew G, Chen C, Christensen B. Mosquito transcriptome changes and filarial worm resistance in Armigeres subalbatus. BMC Genomics. 2007;8:463 pubmed
    Armigeres subalbatus is a natural vector of the filarial worm Brugia pahangi, but it rapidly and proficiently kills Brugia malayi microfilariae by melanotic encapsulation. Because B. malayi and B...
  12. Emes R, Thompson F, Moore J, Zang X, Devaney E. Cloning and characterisation of mmc-1, a microfilarial-specific gene, from Brugia pahangi. Int J Parasitol. 2002;32:415-24 pubmed
    Nine differentially expressed genes were cloned from Brugia pahangi in a screen which sought to identify cDNAs that were differentially expressed between the microfilariae from the mammalian host and the mosquito vector...
  13. Gillan V, Maitland K, McCormack G, Him N, Devaney E. Functional genomics of hsp-90 in parasitic and free-living nematodes. Int J Parasitol. 2009;39:1071-81 pubmed publisher
    ..of hsp-90 from three nematodes, the free-living Caenorhabditis elegans (Ce) and the parasitic worms Brugia pahangi (Bp) and Haemonchus contortus (Hc)...
  14. Gillan V, Devaney E. Mosquito transmission modulates the immune response in mice infected with the L3 of Brugia pahangi. Parasite Immunol. 2004;26:359-63 pubmed
    Mice infected by syringe inoculation with the L3 of the filarial nematode Brugia pahangi generate a strong Th2 response...
  15. Devaney E, O Neill K, Harnett W, Whitesell L, Kinnaird J. Hsp90 is essential in the filarial nematode Brugia pahangi. Int J Parasitol. 2005;35:627-36 pubmed
    ..of the activity of the heat shock protein 90 (Hsp90) family, kills adult worms and microfilariae (Mf) of Brugia pahangi at nanomolar concentrations...
  16. Chirgwin S, Coleman S, Porthouse K, Nowling J, Punkosdy G, Klei T. Removal of Wolbachia from Brugia pahangi is closely linked to worm death and fecundity but does not result in altered lymphatic lesion formation in Mongolian gerbils (Meriones unguiculatus). Infect Immun. 2003;71:6986-94 pubmed
    ..bacteria are relatives of the arthropod symbiont Wolbachia and occur in many filarial nematodes, including Brugia pahangi and Brugia malayi...
  17. Fujimaki Y, Kamachi T, Yanagi T, Caceres A, Maki J, Aoki Y. Macrofilaricidal and microfilaricidal effects of Neurolaena lobata, a Guatemalan medicinal plant, on Brugia pahangi. J Helminthol. 2005;79:23-8 pubmed
    ..Guatemalan medicinal plants were initially screened in vitro for potential macrofilaricidal activity against Brugia pahangi, a lymphatic dwelling filarial worm, using concentrations from 125 to 1000 microg ml(-1) of each extract that ..
  18. Townson S, Hutton D, Siemienska J, Hollick L, Scanlon T, Tagboto S, et al. Antibiotics and Wolbachia in filarial nematodes: antifilarial activity of rifampicin, oxytetracycline and chloramphenicol against Onchocerca gutturosa, Onchocerca lienalis and Brugia pahangi. Ann Trop Med Parasitol. 2000;94:801-16 pubmed
    ..25 mg/kg daily, for 15 days), all three antibiotics were tested against adult Brugia pahangi in the peritoneal cavities of jirds...
  19. Nuchprayoon S, Sangprakarn S, Junpee A, Nithiuthai S, Chungpivat S, Poovorawan Y. Differentiation of Brugia malayi and Brugia pahangi by PCR-RFLP of ITS1 and ITS2. Southeast Asian J Trop Med Public Health. 2003;34 Suppl 2:67-73 pubmed
    ..malayi from B. pahangi. This PCR-RFLP technique will be useful for lymphatic filariasis control programs for monitoring and evaluating animal reservoirs...
  20. Thompson F, Cockroft A, Wheatley I, Britton C, Devaney E. Heat shock and developmental expression of hsp83 in the filarial nematode Brugia pahangi. Eur J Biochem. 2001;268:5808-15 pubmed
    hsp83 was cloned from the filarial nematode Brugia pahangi. The mRNA was constitutively expressed at 37 degrees C in life cycle stages that live in the mammalian host (microfilariae and adult worms)...
  21. Beerntsen B, Bartholomay L, Lowery R. Penetration of the mosquito midgut is not required for Brugia pahangi microfilariae to avoid the melanotic encapsulation response of Armigeres subalbatus. Vet Parasitol. 2007;144:371-4 pubmed
    ..subalbatus, but Brugia pahangi mf evade or suppress the immune response and develop normally into infective stage larvae...
  22. Chirgwin S, Elzer P, Coleman S, Nowling J, Hagius S, Edmonds M, et al. Infection outcome and cytokine gene expression in Brugia pahangi- infected gerbils (Meriones unguiculatus) sensitized with Brucella abortus. Infect Immun. 2002;70:5938-45 pubmed
    ..pahangi intraperitoneally. The data presented here suggest a complex relationship between the host immune response and parasite establishment and survival that cannot be simply ascribed to the Th1/Th2 paradigm...
  23. Dutton T, Sinkins S. Filarial susceptibility and effects of Wolbachia in Aedes pseudoscutellaris mosquitoes. Med Vet Entomol. 2005;19:60-5 pubmed
    ..by tetracycline treatment, and tested filarial susceptibility of the adult female mosquitoes using Brugia pahangi (Edeson & Buckley)...
  24. Porthouse K, Chirgwin S, Coleman S, Taylor H, Klei T. Inflammatory responses to migrating Brugia pahangi third-stage larvae. Infect Immun. 2006;74:2366-72 pubmed publisher
    ..These studies aimed to define early tissue migration of Brugia pahangi L3 in the gerbil (Meriones unguiculatus) and measure host cellular responses during this period...
  25. Winter A, Weir W, Hunt M, Berriman M, Gilleard J, Devaney E, et al. Diversity in parasitic nematode genomes: the microRNAs of Brugia pahangi and Haemonchus contortus are largely novel. BMC Genomics. 2012;13:4 pubmed publisher
    ..Here we describe the the miRNA repertoire of two important parasitic nematodes as an essential first step in addressing this question...
  26. Kramer L, Passeri B, Corona S, Simoncini L, Casiraghi M. Immunohistochemical/immunogold detection and distribution of the endosymbiont Wolbachia of Dirofilaria immitis and Brugia pahangi using a polyclonal antiserum raised against WSP (Wolbachia surface protein). Parasitol Res. 2003;89:381-6 pubmed
    ..immitis and Brugia pahangi using polyclonal antibodies raised against the recombinant Wolbachia surface protein (WSP)...
  27. Khunkitti W, Fujimaki Y, Aoki Y. In vitro antifilarial activity of extracts of the medicinal plant Cardiospermum halicacabum against Brugia pahangi. J Helminthol. 2000;74:241-6 pubmed
    ..and aqueous extracts of the medicinal plant Cardiospermum halicacabum on adult worms and microfilariae of Brugia pahangi were investigated...
  28. Thanchomnang T, Intapan P, Chungpivat S, Lulitanond V, Maleewong W. Differential detection of Brugia malayi and Brugia pahangi by real-time fluorescence resonance energy transfer PCR and its evaluation for diagnosis of B. pahangi-infected dogs. Parasitol Res. 2010;106:621-5 pubmed publisher
    ..energy transfer PCR combined with melting curve analysis was developed for differentiating Brugia malayi and Brugia pahangi DNA in host blood using one set of primers and fluorophore-labeled hybridization probes specific for HhaI ..
  29. Sacchi L, Corona S, Kramer L, Calvi L, Casiraghi M, Franceschi A. Ultrastructural evidence of the degenerative events occurring during embryogenesis of the filarial nematode Brugia pahangi after tetracycline treatment. Parassitologia. 2003;45:89-96 pubmed
    ..we demonstrate by transmission electron microscopy the degenerative events occurring during embryogenesis of Brugia pahangi after tetracycline treatment...
  30. Weinkopff T, Atwood J, Punkosdy G, Moss D, Weatherly D, Orlando R, et al. Identification of antigenic Brugia adult worm proteins by peptide mass fingerprinting. J Parasitol. 2009;95:1429-35 pubmed publisher
    ..We identified 18 unique proteins, several of which were determined to be antigenic by immunoblot. The proteins identified here may contribute to future studies to analyze the transmission and pathogenesis of lymphatic filariasis. ..
  31. Al Abd N, Nor Z, Kassim M, Mansor M, Al Adhroey A, Ngui R, et al. Prevalence of filarial parasites in domestic and stray cats in Selangor State, Malaysia. Asian Pac J Trop Med. 2015;8:705-9 pubmed publisher
    To determine the prevalence of the filarial parasites,ie.,Brugia malayi, Brugia, Brugia pahangi(B. pahangi), Dirofilaria immitisandDirofilaria repens (D. repens) in domestic and stray cats...
  32. Dash Y, Ramesh M, Kalyanasundaram R, Munirathinam G, Shultz L, Rajan T. Granuloma formation around filarial larvae triggered by host responses to an excretory/secretory antigen. Infect Immun. 2011;79:838-45 pubmed publisher
    ..of mice showed that the cohort immunized with BmALT-2 cleared a challenge infection with infective Brugia pahangi L3 in an accelerated manner, whereas cohorts immunized with TCTP cleared larvae with the same kinetics as in ..
  33. Stepek G, Auchie M, Tate R, Watson K, Russell D, Devaney E, et al. Expression of the filarial nematode phosphorylcholine-containing glycoprotein, ES62, is stage specific. Parasitology. 2002;125:155-64 pubmed
    ..To obtain evidence for this, we investigated production by Brugia pahangi, a close relation of B. malayi. We found that ES62 was indeed secreted but, as with A...
  34. Alworth L, Berghaus R, Kelly L, Supakorndej P, Burkman E, Savadelis M, et al. Assessment of Blood Collection from the Lateral Saphenous Vein for Microfilaria Counts in Mongolian Gerbils (Meriones unguiculatus) Infected with Brugia pahangi. Comp Med. 2015;65:492-8 pubmed
    ..counts in blood samples collected by both methods from 21 gerbils infected with the filarial parasitic worm Brugia pahangi. Lateral saphenous vein counts were equivalent to retroorbital counts at relatively high counts (greater than ..
  35. Estambale B, Simonsen P, Vennervald B, Knight R, Bwayo J. Bancroftian filariasis in Kwale District of Kenya. II. Humoral immune responses to filarial antigens in selected individuals from an endemic community. Ann Trop Med Parasitol. 1994;88:153-61 pubmed
    ..Most individuals showed an immunological response to the filarial antigen (prepared from adult Brugia pahangi)...
  36. Bloch P, Nielsen N, Meyrowitsch D, Malecela M, Simonsen P. A 22 year follow-up study on lymphatic filariasis in Tanzania: analysis of immunological responsiveness in relation to long-term infection pattern. Acta Trop. 2011;120:258-67 pubmed publisher
    ..filarial antigenemia and cellular and humoral immunoresponsiveness to crude antigen homogenates prepared from Brugia pahangi parasite material. 85...
  37. Kumar Y, Green R, Borysko K, Wise D, Wotring L, Townsend L. Synthesis of 2,4-disubstituted thiazoles and selenazoles as potential antitumor and antifilarial agents: 1. Methyl 4-(isothiocyanatomethyl)thiazole-2-carbamates, -selenazole-2- carbamates, and related derivatives. J Med Chem. 1993;36:3843-8 pubmed
    ..This compound was inactive against Brugia pahangi at a dosage of 100 mg/kg x 5 days.
  38. Balmer P, Devaney E. NK T cells are a source of early interleukin-4 following infection with third-stage larvae of the filarial nematode Brugia pahangi. Infect Immun. 2002;70:2215-9 pubmed
    Infection of C57BL/6 mice with the third-stage larvae of Brugia pahangi results in a rapid expansion of NK1.1(+) T cells in the spleen and draining lymph nodes...
  39. Casiraghi M, McCall J, Simoncini L, Kramer L, Sacchi L, Genchi C, et al. Tetracycline treatment and sex-ratio distortion: a role for Wolbachia in the moulting of filarial nematodes?. Int J Parasitol. 2002;32:1457-68 pubmed
    ..To address this issue, we designed a first experiment on a model filaria (Brugia pahangi), maintained in the gerbil (Meriones unguiculatus)...
  40. Stepek G, Houston K, Goodridge H, Devaney E, Harnett W. Stage-specific and species-specific differences in the production of the mRNA and protein for the filarial nematode secreted product, ES-62. Parasitology. 2004;128:91-8 pubmed
    ..RT-PCR, in different life-cycle stages of 2 model filarial nematode parasites, Acanthocheilonema viteae and Brugia pahangi. For B...
  41. Rathaur S, Sharma S, Singh R, Henkle K, Selkirk M. Antibody responses of Wuchereria bancrofti patients to recombinant Brugia pahangi superoxide dismutase. Indian J Exp Biol. 2001;39:35-40 pubmed
    ..The apparent molecular masses as determined by immunoblotting were 29 and 22 kDa. The specificity of recombinant SOD could be explored for its use in immunodiagnosis of lymphatic filariasis. ..
  42. Kariuki M, Hearne L, Beerntsen B. Differential transcript expression between the microfilariae of the filarial nematodes, Brugia malayi and B. pahangi. BMC Genomics. 2010;11:225 pubmed publisher
    ..malayi and B. pahangi microfilariae especially because these microfilariae are capable of surviving in the same vertebrate host but elicit different immune response outcomes in the mosquito, Ar. subalbatus. ..
  43. Rolfe R, Barrett J, Perry R. Electrophysiological analysis of responses of adult females of Brugia pahangi to some chemicals. Parasitology. 2001;122:347-57 pubmed
    ..used to obtain recordings of extracellular electrical activity from the anterior end of live adult females of Brugia pahangi. Stimulation with 100 mM, 10 mM and 1 mM acetylcholine resulted in an increase in spike activity which was ..
  44. Orton S, Arasu P, Hammerberg B. A novel gene from Brugia sp. that encodes a cytotoxic fatty acid binding protein allergen recognized by canine monoclonal IgE and serum IgE from infected dogs. J Parasitol. 2007;93:1378-87 pubmed publisher
    b>Brugia pahangi infection of dogs is a well characterized model of human lymphatic filariasis in which sera consistently show IgG or IgE reactivity to a 35-kDa antigen...
  45. Vanapalli S, Hung Y, Fleckenstein L, Dzimianski M, McCall J. Pharmacokinetics and dose proportionality of oral moxidectin in beagle dogs. Biopharm Drug Dispos. 2002;23:263-72 pubmed
    ..and dose proportionality of moxidectin in beagle dogs experimentally infected with the filarial parasite Brugia pahangi, and to evaluate and compare the results obtained from population pharmacokinetic analysis and individual ..
  46. Kinnamon K, Engle R, Poon B, Ellis W, McCall J, Dzimianski M. Polyamines: agents with macrofilaricidal activity. Ann Trop Med Parasitol. 1999;93:851-8 pubmed
    ..The 78 prospective drugs selected were evaluated for their macrofilaricidal activity against Brugia pahangi and Acanthocheilonema viteae, in male Mongolian jirds (Meriones unguiculatus)...
  47. Fujita K. [Diagnostic tests: Filaria]. Nihon Rinsho. 2005;63 Suppl 7:283-5 pubmed
  48. Guiliano D, Hong X, McKerrow J, Blaxter M, Oksov Y, Liu J, et al. A gene family of cathepsin L-like proteases of filarial nematodes are associated with larval molting and cuticle and eggshell remodeling. Mol Biochem Parasitol. 2004;136:227-42 pubmed
    ..We show that in the lymphatic filarial nematode Brugia pahangi molting of third-stage larvae (L3) to fourth-stage larvae is dependent on the activity of a cathepsin L-like ..
  49. O Connor R, Devaney E. Nitric oxide limits the expansion of antigen-specific T cells in mice infected with the microfilariae of Brugia pahangi. Infect Immun. 2002;70:5997-6004 pubmed
    Infection of BALB/c mice with the microfilariae (Mf) of the filarial nematode Brugia pahangi results in an antigen-specific proliferative defect that is induced by high levels of NO...
  50. Chirgwin S, Nowling J, Coleman S, Klei T. Effect of immunostimulatory oligodeoxynucleotides on host responses and the establishment of Brugia pahangi in Mongolian gerbils (Meriones unguiculatus). J Parasitol. 2003;89:483-9 pubmed
    ..pahangi antigen bound to beads embolized in their lungs, regardless of treatment group, suggesting that IL-4 and IL-5 are not essential contributors to the systemic host inflammatory response to B. pahangi in this model...
  51. McNabb S, Ashburner M. Identification of a Drosophila protein similar to rat S13 and archaebacterial S11 ribosomal proteins. Nucleic Acids Res. 1993;21:2523 pubmed
  52. Mitsui Y, Miura M, Bome D, Aoki Y. In vitro chemotactic responses of Brugia pahangi infective larvae to sodium ions. J Helminthol. 2012;86:406-9 pubmed publisher
    In vitro chemotactic responses of infective third-stage larvae (L3) of Brugia pahangi to NaCl, Na2HPO4, KCl, K2HPO4, MgCl2 and CaCl2 were assessed...
  53. Weerasooriya M, Itoh M, Islam M, Aoki Y, Samarawickrema W, Kimura E. Presence and gradual disappearance of filaria-specific urinary IgG4 in babies born to antibody-positive mothers: a 2-year follow-up study. Parasitol Int. 2008;57:386-9 pubmed publisher
    A total of 14 Sri Lankan pregnant women, who were anti-Brugia pahangi urinary IgG4 positive, and their 14 newborn babies were followed up for the urinary antibody for 2 years by enzyme-linked immunosorbent assay...
  54. Thompson F, Martin S, Devaney E. Brugia pahangi: characterisation of a small heat shock protein cDNA clone. Exp Parasitol. 1996;83:259-66 pubmed
    Microfilariae of Brugia pahangi undergo a transition in their life cycle from the homeothermic mammalian host to the poikilothermic mosquito vector. Coincident with this switch, the developmental cycle of the microfilaria is reinitiated...
  55. Nuchprayoon S, Junpee A, Poovorawan Y, Scott A. Detection and differentiation of filarial parasites by universal primers and polymerase chain reaction-restriction fragment length polymorphism analysis. Am J Trop Med Hyg. 2005;73:895-900 pubmed
    ..8S ribosomal DNA (rDNA) were isolated and cloned from Wuchereria bancrofti, Brugia malayi, and Brugia pahangi. Sequence analysis identified conserved sites in the 18S and 5...
  56. Paciorkowski N, Shultz L, Rajan T. Primed peritoneal B lymphocytes are sufficient to transfer protection against Brugia pahangi infection in mice. Infect Immun. 2003;71:1370-8 pubmed
    ..In this communication, we examine the role of B lymphocytes in antifilarial immunity, using Brugia pahangi infections in the murine peritoneal cavity as a model...
  57. Al Abd N, Nor Z, Junaid Q, Mansor M, Hasan M, Kassim M. Antifilarial activity of caffeic acid phenethyl ester on Brugia pahangi in vitro and in vivo. Pathog Glob Health. 2017;111:388-394 pubmed publisher
    ..Anti-Wolbachia and antifilarial properties of CAPE require further investigation as an alternative strategy to treat LF...
  58. Satoh M, Tsukidate S, Eishi Y, Tamura N, Yamamoto K, Fujita K. Suppression of mitogen-induced IL-2R alpha expression in PBL by serum from microfilaraemic rats chronically infected with Brugia pahangi. Parasitology. 1997;114 ( Pt 1):65-9 pubmed
    ..receptor alpha (IL-2R alpha) expression in the peripheral blood lymphocytes (PBL) of Lewis rats infected with Brugia pahangi was observed by flow cytometry...
  59. Beerntsen B, Lowery R. Response of Armigeres subalbatus (Diptera: Culicidae) to intraperitoneally isolated Brugia spp. microfilariae. J Med Entomol. 2007;44:295-8 pubmed
    ..Using the biologically and morphologically similar parasites Brugia malayi and Brugia pahangi and the mosquito Armigeres subalbatus (Coquillett) (Diptera: Culicidae), it should be possible to dissect out ..
  60. Aliota M, Fuchs J, Rocheleau T, Clark A, HILLYER J, Chen C, et al. Mosquito transcriptome profiles and filarial worm susceptibility in Armigeres subalbatus. PLoS Negl Trop Dis. 2010;4:e666 pubmed publisher
    Armigeres subalbatus is a natural vector of the filarial worm Brugia pahangi, but it kills Brugia malayi microfilariae by melanotic encapsulation. Because B. malayi and B. pahangi are morphologically and biologically similar, comparing Ar...
  61. Dash Y, Ramesh M, Greiner D, Shultz L, Klei T, Rajan T. Determinants of memory in experimental filarial infections in mice. Parasite Immunol. 2007;29:567-74 pubmed
    ..and duration of memory responses against filarial parasites using an intraperitoneal mouse model of Brugia pahangi infection. We assessed the role of T cells in the memory response against B...
  62. Paciorkowski N, Porte P, Shultz L, Rajan T. B1 B lymphocytes play a critical role in host protection against lymphatic filarial parasites. J Exp Med. 2000;191:731-6 pubmed
    ..During our investigations into the course of Brugia malayi and Brugia pahangi infections in immunodeficient mouse models, we found that mice lacking B lymphocytes were permissive for ..
  63. Sacchi L. [Ultrastructural basis of interactions between prokaryotes and eukaryotes in different symbiotic models]. Parassitologia. 2004;46:19-24 pubmed
    ..We evidenced, by TEM, the degenerative events occurring during the embriogenesis of Brugia pahangi and Dirofilaria immitis after tetracycline treatment...
  64. Arnold K, Venegas A, Houseweart C, Fuhrman J. Discrete transcripts encode multiple chitinase isoforms in Brugian microfilariae. Mol Biochem Parasitol. 1996;80:149-58 pubmed
    ..pahangi microfilariae. Homologous and cross-species RNAse protection assays verified that multiple transcripts also encode chitinase isozymes in B. pahangi microfilariae...
  65. Kimura E, Fujimaki Y, Niwat M, Fujiwara M, Kadosaka T. Effects of Brugia pahangi infection on the cardiovascular system of stroke-prone spontaneously hypertensive rats. J Parasitol. 2002;88:839-42 pubmed
    ..the cardiovascular system of the host animal, stroke-prone spontaneously hypertensive rats were infected with Brugia pahangi under the assumption that these rats would reveal pathological changes more clearly and in a shorter period ..
  66. Riley S, Donnelly C, Ferguson N. Robust parameter estimation techniques for stochastic within-host macroparasite models. J Theor Biol. 2003;225:419-30 pubmed
    ..This indicates that the observed aggregation of parasite load may be dynamically generated by random variation in the development of an effective immune response against parasite larvae...
  67. Pilakasiri K, Roongruangchai J, Roongruangchai K, Pilakasiri C, Sobhon P. The ultrastructure of the gravid uterus of Brugia pahangi, another rich source of antigen of the filarial parasite. Southeast Asian J Trop Med Public Health. 2005;36:1096-104 pubmed
    The gravid uterus with zygotes and microfilariae in utero of Brugia pahangi, a rich source of antigen as revealed by a recent immunofluorescent technique, were studied ultrastructurally...
  68. Sundberg R, Biswas S, Kumar Murthi K, Rowe D, McCall J, Dzimianski M. Bis-cationic heteroaromatics as macrofilaricides: synthesis of bis-amidine and bis-guanylhydrazone derivatives of substituted imidazo[1,2-a]pyridines. J Med Chem. 1998;41:4317-28 pubmed
    ..have been prepared and evaluated for macrofilarial activity against Acanthocheilonema viteae and Brugia pahangi in jirds. Compounds with 4',6-bis-substitution by cyclic guanylhydrazone groups show activity...
  69. Griffiths K, Mayhew G, Zink R, Erickson S, Fuchs J, McDermott C, et al. Use of microarray hybridization to identify Brugia genes involved in mosquito infectivity. Parasitol Res. 2009;106:227-35 pubmed publisher
    Brugia malayi and Brugia pahangi microfilariae (mf) require a maturation period of at least 5 days in the mammalian host to successfully infect laboratory mosquitoes...
  70. Kinnamon K, Engle R, Poon B, Ellis W, McCall J, Dzimianski M. Anticancer agents suppressive for adult parasites of filariasis in Mongolian jirds. Proc Soc Exp Biol Med. 2000;224:45-9 pubmed
    ..total of 79 compounds with anticancer properties were evaluated for possible macrofilaricidal activity against Brugia pahangi and Acanthocheilonema viteae transplanted into male Mongolian jirds (Meriones unguiculatus)...
  71. Hunter S, Thompson F, Tetley L, Devaney E. Temperature is a cue for gene expression in the post-infective L3 of the parasitic nematode Brugia pahangi. Mol Biochem Parasitol. 2001;112:1-9 pubmed
    ..expression pattern of two genes, Bp-cdd and Bp-S3, was studied at defined points throughout the life cycle of Brugia pahangi. Both mRNAs were up-regulated to coincide with the transition of the L3 from the vector to the mammalian host...
  72. Areekit S, Khuchareontaworn S, Kanjanavas P, Sriyapai T, Pakpitchareon A, Khawsak P, et al. Molecular genetics analysis for co-infection of Brugia malayi and Brugia pahangi in cat reservoirs based on internal transcribed spacer region 1. Southeast Asian J Trop Med Public Health. 2009;40:30-4 pubmed
    This study described the diagnosis of a mixed infection of Brugia malayi and Brugia pahangi in a single domestic cat using the internal transcribed spacer 1 (ITS1) region...
  73. Fujimaki Y, Sithithaworn P, Mitsui Y, Aoki Y. Delayed macrofilaricidal activity of diethylcarbamazine against Brugia pahangi in Mongolian jirds. J Helminthol. 2004;78:293-5 pubmed
    The macrofilaricidal activity of diethylcarbamazine (DEC) was confirmed in jirds infected with Brugia pahangi. Seventy jirds were inoculated subcutaneously with 100 infective larvae...
  74. Jenson J, O CONNOR R, Osborne J, Devaney E. Infection with Brugia microfilariae induces apoptosis of CD4(+) T lymphocytes: a mechanism of immune unresponsiveness in filariasis. Eur J Immunol. 2002;32:858-67 pubmed
    ..In this study we demonstrate that splenic lymphocytes from mice infected with microfilariae of Brugia pahangi display an Ag-specific proliferative defect...
  75. Vande Waa E, Foster L, Deruiter J, Guderian R, Williams J, Geary T. Glutamine-supported motility of adult filarial parasites in vitro and the effect of glutamine antimetabolites. J Parasitol. 1993;79:173-80 pubmed
    The survival in culture of adult female Brugia pahangi, Acanthocheilonema viteae, and Onchocerca volvulus and adult male Onchocerca gibsoni was assessed by measuring parasite motility...
  76. Gebhard D, Orton S, Edmiston D, Nakagaki K, DeBoer D, Hammerberg B. Canine IgE monoclonal antibody specific for a filarial antigen: production by a canine x murine heterohybridoma using B cells from a clinically affected lymph node. Immunology. 1995;85:429-34 pubmed
    ..lymph node cells taken at the onset of clinical disease from a rear limb infected with the filarial nematode Brugia pahangi were fused with mouse myeloma cell line P3X63.Ag8.653 cells...
  77. Simoncini L, Casiraghi M, Bazzocchi C, Sacchi L, Bandi C, Genchi C. Real-time PCR for quantification of the bacterial endosymbionts (Wolbachia) of filarial nematodes. Parassitologia. 2001;43:173-8 pubmed
    ..To this purpose, we designed a quantitative real-time PCR targeted on the ftsZ gene of the Wolbachia of Brugia pahangi, a model filarial species maintained in gerbils...
  78. Drovandi C, Pettitt A. Estimation of parameters for macroparasite population evolution using approximate bayesian computation. Biometrics. 2011;67:225-33 pubmed publisher
    ..The fitted model explains the observed extra-binomial variation in terms of a zero-one immunity variable, which has a short-lived presence in the host...
  79. Itoh M, Wu W, Sun D, Yao L, Li Z, Islam M, et al. Confirmation of elimination of lymphatic filariasis by an IgG4 enzyme-linked immunosorbent assay with urine samples in Yongjia, Zhejiang Province and Gaoan, Jiangxi Province, People's Republic of China. Am J Trop Med Hyg. 2007;77:330-3 pubmed
    ..If similar results are obtained in different filariasis-endemic countries, this method may be useful in global filariasis elimination programs...
  80. Martin H, Shakya K, Muthupalani S, Ge Z, Klei T, Whary M, et al. Brugia filariasis differentially modulates persistent Helicobacter pylori gastritis in the gerbil model. Microbes Infect. 2010;12:748-58 pubmed publisher
    ..pylori and Brugia pahangi mono- and coinfected gerbils. H...
  81. Fischer P, Wibowo H, Pischke S, Ruckert P, Liebau E, Ismid I, et al. PCR-based detection and identification of the filarial parasite Brugia timori from Alor Island, Indonesia. Ann Trop Med Parasitol. 2002;96:809-21 pubmed
    ..malayi by other molecular markers. PCR-based techniques targeting the HhaI repeat can therefore be employed for monitoring B. timori in the framework of the Global Programme to Eliminate Lymphatic Filariasis...
  82. Al Azzam S, Fleckenstein L, Cheng K, Dzimianski M, McCall J. Comparison of the pharmacokinetics of moxidectin and ivermectin after oral administration to beagle dogs. Biopharm Drug Dispos. 2007;28:431-8 pubmed
    ..and moxidectin after oral administration to beagle dogs experimentally infected with the filarial parasite, Brugia pahangi. Sixteen dogs were selected and randomly allocated into two groups of eight dogs each...
  83. Areekit S, Singhaphan P, Khuchareontaworn S, Kanjanavas P, Sriyaphai T, Pakpitchareon A, et al. Intraspecies variation of Brugia spp. in cat reservoirs using complete ITS sequences. Parasitol Res. 2009;104:1465-9 pubmed publisher
    ..a maximum likelihood approach based on ITS nucleotide sequences and was compared to those of Brugia malayi, Brugia pahangi, and Dirofilaria immitis that were previously reported in GenBank...
  84. Kato N, Mueller C, Fuchs J, McElroy K, Wessely V, Higgs S, et al. Evaluation of the function of a type I peritrophic matrix as a physical barrier for midgut epithelium invasion by mosquito-borne pathogens in Aedes aegypti. Vector Borne Zoonotic Dis. 2008;8:701-12 pubmed publisher
    ..this artificial manipulation, we determined that the absence of the PM has no effect on the development of Brugia pahangi or on the dissemination of dengue virus...
  85. Shigeno S, Fujimaki Y, Toriyama K, Ichinose A, Mitsui Y, Aoki Y, et al. Temporary shift of microfilariae of Brugia pahangi from the lungs to muscles in Mongolian jirds, Meriones unguiculatus, after a single injection of diethylcarbamazine. J Parasitol. 2006;92:1075-80 pubmed
    A single-dose treatment with diethylcarbamazine (DEC) reduced microfilaria (mf) counts of Brugia pahangi by >90% at 30 min post-treatment in Mongolian jirds (Meriones unguiculatus)...