ascaris suum

Summary

Summary: A species of parasitic nematode usually found in domestic pigs and a few other animals. Human infection can also occur, presumably as result of handling pig manure, and can lead to intestinal obstruction.

Top Publications

  1. Brownlee D, Holden Dye L, Walker R. Actions of the anthelmintic ivermectin on the pharyngeal muscle of the parasitic nematode, Ascaris suum. Parasitology. 1997;115 ( Pt 5):553-61 pubmed
    ..Contraction of Ascaris suum pharyngeal muscle was monitored using a modified pressure transducer system which detects changes in ..
  2. Christie J, Dunbar B, Kennedy M. The ABA-1 allergen of the nematode Ascaris suum: epitope stability, mass spectrometry, and N-terminal sequence comparison with its homologue in Toxocara canis. Clin Exp Immunol. 1993;92:125-32 pubmed
    ..ABA-1 and its homologues might, therefore, be important to the immunopathology of many infections with nematode parasites, upon which the genetic constitution of the hosts will also have a bearing...
  3. Nozoye T, Takaiwa F, Tsuji N, Yamakawa T, Arakawa T, Hayashi Y, et al. Production of Ascaris suum As14 protein and its fusion protein with cholera toxin B subunit in rice seeds. J Vet Med Sci. 2009;71:995-1000 pubmed
    ..In this study, we produced a 14-kDa protective surface antigen of Ascaris suum L3 larvae and its fusion chimera with a mucosal carrier molecule cholera toxin B subunit (CTB) in rice (Oryza ..
  4. Chen N, Xu M, Nisbet A, Huang C, Lin R, Yuan Z, et al. Ascaris suum: RNAi mediated silencing of enolase gene expression in infective larvae. Exp Parasitol. 2011;127:142-6 pubmed publisher
    b>Ascaris suum is an important parasite of pigs that causes tremendous economic losses globally to agriculture and animal husbandry annually...
  5. Sanchez Vazquez M, Smith R, Kang S, Lewis F, Nielen M, Gunn G, et al. Identification of factors influencing the occurrence of milk spot livers in slaughtered pigs: A novel approach to understanding Ascaris suum epidemiology in British farmed pigs. Vet Parasitol. 2010;173:271-9 pubmed publisher
    ..Milk spots are healing lesions occurring when Ascaris suum larvae migrate through the liver. This study aimed to identify current husbandry practices (e.g...
  6. Zhu W, Pryor S, Putnam J, Cadet P, Stefano G. Opiate alkaloids and nitric oxide production in the nematode Ascaris suum. J Parasitol. 2004;90:15-22 pubmed
    The tissue distribution, course of secretion, and sex differences of morphine were delineated in Ascaris suum. Nitric oxide (NO) release in various tissues in response to morphine and its metabolite morphine-6-glucuronide (M6G) were also ..
  7. Lewis R, Behnke J, Stafford P, Holland C. Dose-dependent impact of larval Ascaris suum on host body weight in the mouse model. J Helminthol. 2009;83:1-5 pubmed publisher
    Ascaris lumbricoides and Ascaris suum are important helminth parasites of humans and pigs, respectively...
  8. Li G, Si Y, Feng P. [HE staining of uterus cells of Ascaris suum by egg albumin-glycerine smear technique]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2003;21:123-4 pubmed
  9. Miquel N, Roepstorff A, Bailey M, Eriksen L. Host immune reactions and worm kinetics during the expulsion of Ascaris suum in pigs. Parasite Immunol. 2005;27:79-88 pubmed
    Pigs single inoculated with Ascaris suum eggs expel the majority of larvae between days 14 and 21 post inoculation (p.i.), but the role of the immune system in expulsion is unclear...

More Information

Publications139 found, 100 shown here

  1. Geng J, Plenefisch J, Komuniecki P, Komuniecki R. Secretion of a novel developmentally regulated chitinase (family 19 glycosyl hydrolase) into the perivitelline fluid of the parasitic nematode, Ascaris suum. Mol Biochem Parasitol. 2002;124:11-21 pubmed
    The early development of the parasitic nematode, Ascaris suum, occurs within a chitinous eggshell and an abundant chitinase (As-p50) has been identified in the perivitelline fluid (PVF) surrounding the infective larva prior to hatching...
  2. Dmitryjuk M, Łopieńska Biernat E, Farjan M. The level of sugars and synthesis of trehalose in Ascaris suum tissues. J Helminthol. 2009;83:237-43 pubmed publisher
    ..phosphatase (TPP) were observed in muscles, individual parts of the reproductive system and haemolymph of Ascaris suum. The highest activity of TPS was detected in the upper uterus, while the lowest activity of TPS was detected in ..
  3. Vlaminck J, Martinez Valladares M, DeWilde S, Moens L, Tilleman K, Deforce D, et al. Immunizing pigs with Ascaris suum haemoglobin increases the inflammatory response in the liver but fails to induce a protective immunity. Parasite Immunol. 2011;33:250-4 pubmed publisher
    To determine whether purified Ascaris suum haemoglobin (AsHb) is a suitable vaccine candidate for the control of Ascaris infections, pigs were vaccinated with AsHb in combination with QuilA adjuvant and challenged with A. suum eggs...
  4. Borgsteede F, Gaasenbeek C, Nicoll S, Domangue R, Abbott E. A comparison of the efficacy of two ivermectin formulations against larval and adult Ascaris suum and Oesophagostomum dentatum in experimentally infected pigs. Vet Parasitol. 2007;146:288-93 pubmed
    ..3 mg/kg bodyweight versus placebo in the treatment and control of larval and adult stages of Ascaris suum and Oesophagostomum spp. in experimentally infected pigs...
  5. Oshiro T, Rafael A, Enobe C, Fernandes I, Macedo Soares M. Comparison of different monoclonal antibodies against immunosuppressive proteins of Ascaris suum. Braz J Med Biol Res. 2004;37:223-6 pubmed
    The extract of Ascaris suum suppresses the humoral and cellular immune responses to unrelated antigens in the mouse. In order to further characterize the suppressive components of A...
  6. Kita K, Hirawake H, Miyadera H, Amino H, Takeo S. Role of complex II in anaerobic respiration of the parasite mitochondria from Ascaris suum and Plasmodium falciparum. Biochim Biophys Acta. 2002;1553:123-39 pubmed
    ..Recent research has shown that the mitochondrial complex II plays an important role in the anaerobic energy metabolism of parasites inhabiting hosts, by acting as quinol-fumarate reductase. ..
  7. Karsten W, Liu D, Rao G, Harris B, Cook P. A catalytic triad is responsible for acid-base chemistry in the Ascaris suum NAD-malic enzyme. Biochemistry. 2005;44:3626-35 pubmed
    The pH dependence of kinetic parameters of several active site mutants of the Ascaris suum NAD-malic enzyme was investigated to determine the role of amino acid residues likely involved in catalysis on the basis of three-dimensional ..
  8. Takamiya S, Hashimoto M, Kazuno S, Kikkawa M, Yamakura F. Ascaris suum NADH-methemo(myo)globin reductase systems recovering differential functions of hemoglobin and myoglobin, adapting to environmental hypoxia. Parasitol Int. 2009;58:278-84 pubmed publisher
    We reported previously that Ascaris suum cytochrome b5, specifically expressed in this nematode at the adult stage and dually localized in extracellular perienteric fluid and hypodermis, is involved in both perienteric NADH-methemoglobin ..
  9. Sakakibara A, Baba K, Niwa S, Yagi T, Wakayama H, Yoshida K, et al. Visceral larva migrans due to Ascaris suum which presented with eosinophilic pneumonia and multiple intra-hepatic lesions with severe eosinophil infiltration--outbreak in a Japanese area other than Kyushu. Intern Med. 2002;41:574-9 pubmed
    ..linked immunosorbent assay (DOT-ELISA) and ELISA inhibition test using microtiter plates were positive for Ascaris suum. Thus, visceral larva migrans due to Ascaris suum was diagnosed...
  10. Rao G, Coleman D, Karsten W, Cook P, Harris B. Crystallographic studies on Ascaris suum NAD-malic enzyme bound to reduced cofactor and identification of an effector site. J Biol Chem. 2003;278:38051-8 pubmed
    The crystal structure of the mitochondrial NAD-malic enzyme from Ascaris suum, in a quaternary complex with NADH, tartronate, and magnesium has been determined to 2.0-A resolution...
  11. Tsuji N, Suzuki K, Kasuga Aoki H, Isobe T, Arakawa T, Matsumoto Y. Mice intranasally immunized with a recombinant 16-kilodalton antigen from roundworm Ascaris parasites are protected against larval migration of Ascaris suum. Infect Immun. 2003;71:5314-23 pubmed
    Protective immunity to the pig roundworm, Ascaris suum, has been demonstrated by immunization of pigs with antigens derived from the parasite's larval stages...
  12. Zhou C, Li M, Yuan K, Hu N, Peng W. Phylogeography of Ascaris lumbricoides and A. suum from China. Parasitol Res. 2011;109:329-38 pubmed publisher
    ..This study should have certain enlightenment for the epidemiology and the evolutionary and taxonomy relationship of Ascaris from humans and pigs...
  13. Jungersen G, Eriksen L, Nansen P, Fagerholm H. Sex-manipulated Ascaris suum infections in pigs: implications for reproduction. Parasitology. 1997;115 ( Pt 4):439-42 pubmed
    In spite of the vast distribution and considerable impact on human and animal health of Ascaris suum and A. lumbricoides, little is known of the sexual biology and reproductive capacity of these intestinal nematodes...
  14. Anderson T. The dangers of using single locus markers in parasite epidemiology: Ascaris as a case study. Trends Parasitol. 2001;17:183-8 pubmed
    ..conclusions and to illustrate how a multilocus approach has enhanced our understanding of the epidemiology of two closely related parasites, the nematodes Ascaris suum, which infects pigs, and Ascaris lumbicoides, which infects humans.
  15. Oshiro T, Macedo M, Macedo Soares M. Anti-inflammatory activity of PAS-1, a protein component of Ascaris suum. Inflamm Res. 2005;54:17-21 pubmed
    Recently, we identified a 200 kDa protein (PAS-1) from Ascaris suum worms, that suppresses the humoral immune response...
  16. Rhoads M, Fetterer R, Urban J. Cuticular collagen synthesis by Ascaris suum during development from the third to fourth larval stage: identification of a potential chemotherapeutic agent with a novel mechanism of action. J Parasitol. 2001;87:1144-9 pubmed
    The dominant proteins released by Ascaris suum during development in vitro from the L3 to L4 stage were identified as collagenous cuticular proteins by sequence analysis and susceptibility to digestion by collagenase...
  17. Ohtsuki T, Kawai G, Watanabe K. The minimal tRNA: unique structure of Ascaris suum mitochondrial tRNA(Ser)(UCU) having a short T arm and lacking the entire D arm. FEBS Lett. 2002;514:37-43 pubmed
    The tertiary structure of Ascaris suum mitochondrial tRNA(Ser)(UCU) was examined by nuclear magnetic resonance analysis using its transcript, since tRNA(Ser)(UCU), lacking the D arm and possessing a truncated T arm, is the shortest of all ..
  18. Shimizu H, Osanai A, Sakamoto K, Inaoka D, Shiba T, Harada S, et al. Crystal structure of mitochondrial quinol-fumarate reductase from the parasitic nematode Ascaris suum. J Biochem. 2012;151:589-92 pubmed publisher
    In the anaerobic respiratory chain of the parasitic nematode Ascaris suum, complex II couples the reduction of fumarate to the oxidation of rhodoquinol, a reverse reaction catalyzed by mammalian complex II...
  19. Sures B, Jürges G, Taraschewski H. Relative concentrations of heavy metals in the parasites Ascaris suum (Nematoda) and Fasciola hepatica (Digenea) and their respective porcine and bovine definitive hosts. Int J Parasitol. 1998;28:1173-8 pubmed
    ..significantly higher in the liver and kidney, respectively, of pigs than in their intestinal nematode parasites Ascaris suum. There was no clear pattern in the distribution of lead within the ascarids, but cadmium concentrations were ..
  20. Tsuji N, Suzuki K, Kasuga Aoki H, Matsumoto Y, Arakawa T, Ishiwata K, et al. Intranasal immunization with recombinant Ascaris suum 14-kilodalton antigen coupled with cholera toxin B subunit induces protective immunity to A. suum infection in mice. Infect Immun. 2001;69:7285-92 pubmed
    ..We have identified a cDNA encoding Ascaris suum 14-kDa antigen (As14) and evaluated the vaccinal effect of the Escherichia coli-expressed recombinant protein (..
  21. Pillai A, Ueno S, Zhang H, Lee J, Kato Y. Cecropin P1 and novel nematode cecropins: a bacteria-inducible antimicrobial peptide family in the nematode Ascaris suum. Biochem J. 2005;390:207-14 pubmed
    ..conclusion, and confirmed that this peptide originates in fact from the pig intestinal parasitic nematode, Ascaris suum. In the present study, we carried out a semi-exhaustive search for bacteria-inducible transcripts in A...
  22. Boes J, Medley G, Eriksen L, Roepstorff A, Nansen P. Distribution of Ascaris suum in experimentally and naturally infected pigs and comparison with Ascaris lumbricoides infections in humans. Parasitology. 1998;117 ( Pt 6):589-96 pubmed
    This paper describes the distribution of Ascaris suum in experimentally and naturally infected pigs, and offers a comparison with A. lumbricoides infections in humans...
  23. Kubiak T, Larsen M, Davis J, Zantello M, Bowman J. AF2 interaction with Ascaris suum body wall muscle membranes involves G-protein activation. Biochem Biophys Res Commun. 2003;301:456-9 pubmed
    KHEYLRF-NH(2) (AF2) is the most abundant FMRFamide-related peptide (FaRP) in Ascaris suum and also in many other parasitic and free-living nematodes...
  24. Urban J, Hu Y, Miller M, Scheib U, Yiu Y, Aroian R. Bacillus thuringiensis-derived Cry5B has potent anthelmintic activity against Ascaris suum. PLoS Negl Trop Dis. 2013;7:e2263 pubmed publisher
    b>Ascaris suum and Ascaris lumbricoides are two closely related geo-helminth parasites that ubiquitously infect pigs and humans, respectively. Ascaris suum infection in pigs is considered a good model for A...
  25. Slotved H, Barnes E, Eriksen L, Roepstorff A, Nansen P, Bjørn H. Use of an agar-gel technique for large scale application to recover Ascaris suum larvae from intestinal contents of pigs. Acta Vet Scand. 1997;38:207-12 pubmed
    Four groups each of 3 pigs were inoculated with Ascaris suum eggs. Pigs in groups 1 and 3 were inoculated with 1000 eggs, and pigs in groups 2 and 4 with 10,000 eggs. On day 10 and 21 post-inoculation (p.i...
  26. Keddie E, Higazi T, Unnasch T. The mitochondrial genome of Onchocerca volvulus: sequence, structure and phylogenetic analysis. Mol Biochem Parasitol. 1998;95:111-27 pubmed
    ..volvulus mitochondrial genome is 13747 bp, slightly smaller than the mitochondrial genomes of the nematodes Ascaris suum and Caenorhabditis elegans, and the smallest metazoan mitochondrial DNA molecule reported to date. The O...
  27. Lima C, Perini A, Garcia M, Martins M, Teixeira M, Macedo M. Eosinophilic inflammation and airway hyper-responsiveness are profoundly inhibited by a helminth (Ascaris suum) extract in a murine model of asthma. Clin Exp Allergy. 2002;32:1659-66 pubmed
    ..We have already demonstrated that adult worm extracts from Ascaris suum (ASC) suppress the IgE antibody production against unrelated antigens...
  28. Aitken M, Sobsey M, Blauth K, Shehee M, Crunk P, Walters G. Inactivation of Ascaris suum and poliovirus in biosolids under thermophilic anaerobic digestion conditions. Environ Sci Technol. 2005;39:5804-9 pubmed
    ..We measured inactivation of vaccine-strain poliovirus and eggs from the helminth Ascaris suum at temperatures from 49 to 55 degrees C in a lab-scale batch reactor containing biosolids from a continuous-..
  29. van Krimpen M, Binnendijk G, Borgsteede F, Gaasenbeek C. Anthelmintic effects of phytogenic feed additives in Ascaris suum inoculated pigs. Vet Parasitol. 2010;168:269-77 pubmed publisher
    ..were performed to determine the anthelmintic effect of some phytogenic feed additives on a mild infection of Ascaris suum in growing and finishing pigs. Usually, an infection of A...
  30. Zhang H, Yoshida S, Aizawa T, Murakami R, Suzuki M, Koganezawa N, et al. In vitro antimicrobial properties of recombinant ASABF, an antimicrobial peptide isolated from the nematode Ascaris suum. Antimicrob Agents Chemother. 2000;44:2701-5 pubmed
    ..Less than 1 min of contact was enough to kill Staphylococcus aureus ATCC 6538P. The bactericidal activity against S. aureus was inhibited by salts. ..
  31. Jungersen G, Eriksen L, Nansen P, Lind P, Rasmussen T, Meeusen E. Regional immune responses with stage-specific antigen recognition profiles develop in lymph nodes of pigs following Ascaris suum larval migration. Parasite Immunol. 2001;23:185-94 pubmed
    The early life-cycle of the pig round worm, Ascaris suum, involves well-defined larval development in the liver, lungs and finally the small intestine. Distinct regional immune responses to larval antigens of A...
  32. Urban J, Steenhard N, Solano Aguilar G, Dawson H, Iweala O, Nagler C, et al. Infection with parasitic nematodes confounds vaccination efficacy. Vet Parasitol. 2007;148:14-20 pubmed
    ..In addition, a large animal vaccination and challenge model against Mycoplasma hyopneumonia in swine exposed to Ascaris suum will provide a specific example of the need for further work in this area, and for controlled field studies to ..
  33. Buxton S, Neveu C, Charvet C, Robertson A, Martin R. On the mode of action of emodepside: slow effects on membrane potential and voltage-activated currents in Ascaris suum. Br J Pharmacol. 2011;164:453-70 pubmed publisher
    ..We examined mechanisms of action of emodepside in a parasitic nematode, Ascaris suum. RT-PCR was used to investigate expression of slo-1 and lat-1 in A...
  34. Tsuji N, Miyoshi T, Islam M, Isobe T, Yoshihara S, Arakawa T, et al. Recombinant Ascaris 16-Kilodalton protein-induced protection against Ascaris suum larval migration after intranasal vaccination in pigs. J Infect Dis. 2004;190:1812-20 pubmed
    ..We evaluated the vaccinal effects of this 16-kilodalton protein (As16) in pigs, the natural host of Ascaris suum, by intranasal immunization...
  35. Nakamura Uchiyama F, Tokunaga Y, Suzuki A, Akao N, Hiromatsu K, Hitomi S, et al. A case of Ascaris suum visceral larva migrans diagnosed by using A. suum larval excretory-secretory (ES) antigen. Scand J Infect Dis. 2006;38:221-4 pubmed
    ..Eventually she transpired to have a high IgG antibody titer against excretory-secretary (ES) antigen of Ascaris suum larvae, but not of Toxocara canis larvae, suggesting that she had been suffering from visceral larva migrans (..
  36. Huang C, Gasser R, Cantacessi C, Nisbet A, Zhong W, Sternberg P, et al. Genomic-bioinformatic analysis of transcripts enriched in the third-stage larva of the parasitic nematode Ascaris suum. PLoS Negl Trop Dis. 2008;2:e246 pubmed publisher
    Differential transcription in Ascaris suum was investigated using a genomic-bioinformatic approach. A cDNA archive enriched for molecules in the infective third-stage larva (L3) of A...
  37. Eriksen L, Bøgh H, Loftager M, Lind P. Comparative studies of experimental oral inoculation of pigs with Ascaris suum eggs or third stage larvae. J Vet Med B Infect Dis Vet Public Health. 2004;51:185-90 pubmed
    This experimental study was designed to compare the acquired resistance in pigs to Ascaris suum eggs following 4-weekly oral immunizations with either 200 A. suum infective eggs or 50 A. suum third stage larvae (L3)...
  38. Levandoski M, Robertson A, Kuiper S, Qian H, Martin R. Single-channel properties of N- and L-subtypes of acetylcholine receptor in Ascaris suum. Int J Parasitol. 2005;35:925-34 pubmed
    ..In a contraction assay using the parasitic nematode Ascaris suum, our laboratory has identified several subtypes, including an N-subtype, preferentially activated by nicotine, ..
  39. Wolstenholme D, Okimoto R, Macfarlane J. Nucleotide correlations that suggest tertiary interactions in the TV-replacement loop-containing mitochondrial tRNAs of the nematodes, Caenorhabditis elegans and Ascaris suum. Nucleic Acids Res. 1994;22:4300-6 pubmed
    ..20 of the 22 tRNAs encoded in mitochondrial DNA (mtDNA) molecules of the nematodes, Caenorhabditis elegans and Ascaris suum, the T psi C arm and variable loop are replaced with a loop of 6 to 12 nucleotides: the TV-replacement loop...
  40. Shiomi K, Hatano H, Morimoto H, Ui H, Sakamoto K, Kita K, et al. Decursin and decursinol angelate selectively inhibit NADH-fumarate reductase of Ascaris suum. Planta Med. 2007;73:1478-81 pubmed
    ..They inhibited ASCARIS SUUM NFRD with IC (50) values of 1.1 and 2.7 microM, respectively...
  41. Meenan N, Cooper A, Kennedy M, Smith B. Resonance assignment of ABA-1A, from Ascaris suum nematode polyprotein allergen. J Biomol NMR. 2005;32:176 pubmed
  42. Arizono N, Yoshimura Y, Tohzaka N, Yamada M, Tegoshi T, Onishi K, et al. Ascariasis in Japan: is pig-derived Ascaris infecting humans?. Jpn J Infect Dis. 2010;63:447-8 pubmed
    ..ascariasis is caused by infection with the common roundworm Ascaris lumbricoides, although the pig roundworm Ascaris suum has also been reported to infect humans and develop into the adult stage...
  43. Nejsum P, Betson M, Bendall R, Thamsborg S, Stothard J. Assessing the zoonotic potential of Ascaris suum and Trichuris suis: looking to the future from an analysis of the past. J Helminthol. 2012;86:148-55 pubmed publisher
  44. Dawson H, Beshah E, Nishi S, Solano Aguilar G, Morimoto M, Zhao A, et al. Localized multigene expression patterns support an evolving Th1/Th2-like paradigm in response to infections with Toxoplasma gondii and Ascaris suum. Infect Immun. 2005;73:1116-28 pubmed
    ..study, pigs were inoculated with two clinically and economically important parasites, Toxoplasma gondii and Ascaris suum, and gene expression in 11 different tissues for 20 different swine Th1/Th2-related cytokines, cytokine ..
  45. Araujo C, Perini A, Martins M, Macedo M, Macedo Soares M. PAS-1, a protein from Ascaris suum, modulates allergic inflammation via IL-10 and IFN-gamma, but not IL-12. Cytokine. 2008;44:335-41 pubmed publisher
    ..We have demonstrated that PAS-1, a protein isolated from Ascaris suum worms, has an inhibitory effect on lung allergic inflammation due to its ability to down-regulate eosinophilic ..
  46. Nejsum P, Bertelsen M, Betson M, Stothard J, Murrell K. Molecular evidence for sustained transmission of zoonotic Ascaris suum among zoo chimpanzees (Pan troglodytes). Vet Parasitol. 2010;171:273-6 pubmed publisher
    ..J3 stage and PCR-RFLP analysis on the ITS region amplified from single embryonated eggs suggest these to be Ascaris suum. In addition, sequence analysis of the cox1 gene ('barcoding') on expelled worms followed by cluster analysis ..
  47. Jex A, Liu S, Li B, Young N, Hall R, Li Y, et al. Ascaris suum draft genome. Nature. 2011;479:529-33 pubmed publisher
    ..To enable such molecular studies, we report the 273 megabase draft genome of Ascaris suum and compare it with other nematode genomes. This genome has low repeat content (4...
  48. Wang T, Van Steendam K, Dhaenens M, Vlaminck J, Deforce D, Jex A, et al. Proteomic analysis of the excretory-secretory products from larval stages of Ascaris suum reveals high abundance of glycosyl hydrolases. PLoS Negl Trop Dis. 2013;7:e2467 pubmed publisher
    Ascaris lumbricoides and Ascaris suum are socioeconomically important and widespread parasites of humans and pigs, respectively...
  49. Lall S, Friedman C, Jankowska Anyszka M, Stepinski J, Darzynkiewicz E, Davis R. Contribution of trans-splicing, 5' -leader length, cap-poly(A) synergism, and initiation factors to nematode translation in an Ascaris suum embryo cell-free system. J Biol Chem. 2004;279:45573-85 pubmed
    ..cap (m (2,2,7)(3)GpppG or TMG-cap) to more than 70% of transcripts in the nematodes Caenorhabditis elegans and Ascaris suum. Using an Ascaris embryo cell-free translation system, we found that the TMG-cap and spliced leader sequence ..
  50. Kakihara D, Yoshimitsu K, Ishigami K, Irie H, Aibe H, Tajima T, et al. Liver lesions of visceral larva migrans due to Ascaris suum infection: CT findings. Abdom Imaging. 2004;29:598-602 pubmed
    The purpose of this study was to analyze computed tomographic (CT) findings of hepatic lesions due to Ascaris suum infection. CT of the liver in three patients, all of whom had immunoserologically confirmed A...
  51. Yi K, Buttery S, Stewart M, Roberts T. A Ser/Thr kinase required for membrane-associated assembly of the major sperm protein motility apparatus in the amoeboid sperm of Ascaris. Mol Biol Cell. 2007;18:1816-25 pubmed
    Leading edge protrusion in the amoeboid sperm of Ascaris suum is driven by the localized assembly of the major sperm protein (MSP) cytoskeleton in the same way that actin assembly powers protrusion in other types of crawling cell...
  52. Helwigh A, Nansen P. Establishment of Ascaris suum in the pig: development of immunity following a single primary infection. Acta Vet Scand. 1999;40:121-32 pubmed
    Development of immunity after a single primary infection of Ascaris suum in pigs was investigated with regard to the worm population dynamics of a superimposed A. suum infection, host immune response and gross liver pathological changes...
  53. Silva S, Jacysyn J, Macedo M, Faquim Mauro E. Immunosuppressive components of Ascaris suum down-regulate expression of costimulatory molecules and function of antigen-presenting cells via an IL-10-mediated mechanism. Eur J Immunol. 2006;36:3227-37 pubmed
    High-molecular-weight components (PI) of Ascaris suum suppress both cell-mediated and humoral responses against ovalbumin (OVA) via an IL-4/IL-10-dependent mechanism...
  54. Jensen P, Phuc P, Konradsen F, Klank L, Dalsgaard A. Survival of Ascaris eggs and hygienic quality of human excreta in Vietnamese composting latrines. Environ Health. 2009;8:57 pubmed publisher
    ..By inoculating eggs of the helminth parasite indicator Ascaris suum into heaps of human excreta, a die-off experiment was conducted under conditions similar to those commonly used ..
  55. Roepstorff A, Eriksen L, Slotved H, Nansen P. Experimental Ascaris suum infection in the pig: worm population kinetics following single inoculations with three doses of infective eggs. Parasitology. 1997;115 ( Pt 4):443-52 pubmed
    To study population kinetics during primary Ascaris suum infections, 3 groups of 52 pigs each were inoculated with 100, 1000, or 10,000 infective eggs...
  56. Xu M, Chen N, Song H, Lin R, Huang C, Yuan Z, et al. RNAi-mediated silencing of a novel Ascaris suum gene expression in infective larvae. Parasitol Res. 2010;107:1499-503 pubmed publisher
    ..present study, the potential of RNA interference (RNAi) as a gene silencing tool and the resultant effects on Ascaris suum larval development was examined by targeting a gene (represented by the EST 06G09) specifically expressed in ..
  57. Leles D, Gardner S, Reinhard K, Iñiguez A, Araujo A. Are Ascaris lumbricoides and Ascaris suum a single species?. Parasit Vectors. 2012;5:42 pubmed publisher
    Since the original description and naming of Ascaris lumbricoides from humans by Linnaeus in 1758 and later of Ascaris suum from pigs by Goeze 1782, these species have been considered to be valid...
  58. Loreille O, Bouchet F. Evolution of ascariasis in humans and pigs: a multi-disciplinary approach. Mem Inst Oswaldo Cruz. 2003;98 Suppl 1:39-46 pubmed
    ..4 billion people worldwide, and its sister species, Ascaris suum, has infected a countless number of domesticated and feral pigs...
  59. Pecson B, Nelson K. Inactivation of Ascaris suum eggs by ammonia. Environ Sci Technol. 2005;39:7909-14 pubmed
    ..research were to determine the conditions under which ammonia inactivates eggs of the swine Ascaris species, Ascaris suum, and to quantify the impact of ammonia on the U.S...
  60. Roepstorff A, Murrell K. Transmission dynamics of helminth parasites of pigs on continuous pasture: Ascaris suum and Trichuris suis. Int J Parasitol. 1997;27:563-72 pubmed
    ..outdoor production systems for pigs are becoming more frequent, and information on the transmission of Ascaris suum and Trichuris suis under continuously grazed pasture conditions is needed...
  61. Johnson P, Dixon R, Ross A. An in-vitro test for assessing the viability of Ascaris suum eggs exposed to various sewage treatment processes. Int J Parasitol. 1998;28:627-33 pubmed
    A simple procedure using Ascaris suum as a model for Ascaris lumbricoides in testing the ability of sludge treatment processes to kill the eggs of parasitic roundworms was developed. Unembryonated and embryonated A...
  62. Izumikawa K, Kohno Y, Izumikawa K, Hara K, Hayashi H, Maruyama H, et al. Eosinophilic pneumonia due to visceral larva migrans possibly caused by Ascaris suum: a case report and review of recent literatures. Jpn J Infect Dis. 2011;64:428-32 pubmed
    ..man who developed eosinophilic pneumonia due to visceral larva migrans (VLM) that was possibly caused by Ascaris suum. The patient, a resident of the middle Kyushu area who was found of eating raw porcine liver, complained of dry ..
  63. Dale V, Martin R. Oxantel-activated single channel currents in the muscle membrane of Ascaris suum. Parasitology. 1995;110 ( Pt 4):437-48 pubmed
    ..receptor (nAChR) currents recorded from vesicles of the somatic muscle cells of the nematode parasite Ascaris suum. The amplitudes of the currents were analysed at different membrane potentials to determine the single channel ..
  64. Morimoto M, Zarlenga D, Beard H, Alkharouf N, Matthews B, Urban J. Ascaris suum: cDNA microarray analysis of 4th stage larvae (L4) during self-cure from the intestine. Exp Parasitol. 2003;104:113-21 pubmed
    There is spontaneous cure of a large portion of Ascaris suum 4th-stage larvae (L4) from the jejunum of infected pigs between 14 and 21 days after inoculation (DAI)...
  65. Kim J, Oh D, Ahn K, Shin S. Effects of kimchi extract and temperature on embryostasis of Ascaris suum eggs. Korean J Parasitol. 2012;50:83-7 pubmed publisher
    To determine the effects of kimchi extracts at different temperatures on larval development, Ascaris suum eggs were mixed with soluble part of 7 different brands of commercially available kimchi and preserved at either 5? or 25? for up to ..
  66. Gao G, Raikar S, Davenport B, Mutapcic L, Montgomery R, Kuzmin E, et al. Cross-species RNAi: selected Ascaris suum dsRNAs can sterilize Caenorhabditis elegans. Mol Biochem Parasitol. 2006;146:124-8 pubmed
  67. Qian H, Martin R, Robertson A. Pharmacology of N-, L-, and B-subtypes of nematode nAChR resolved at the single-channel level in Ascaris suum. FASEB J. 2006;20:2606-8 pubmed
    Pharmacological experiments on Ascaris suum have demonstrated the presence of three (N-, L-, and B-) subtypes of cholinergic receptor mediating contraction of body wall muscle in parasitic nematodes...
  68. Nejsum P, Thamsborg S, Petersen H, Kringel H, Fredholm M, Roepstorff A. Population dynamics of Ascaris suum in trickle-infected pigs. J Parasitol. 2009;95:1048-53 pubmed publisher
    The population dynamics of Ascaris suum was studied by long-term exposure of pigs to infective eggs. The pigs were experimentally inoculated with 25 A...
  69. Islam M, Miyoshi T, Tsuji N. Vaccination with recombinant Ascaris suum 24-kilodalton antigen induces a Th1/Th2-mixed type immune response and confers high levels of protection against challenged Ascaris suum lung-stage infection in BALB/c mice. Int J Parasitol. 2005;35:1023-30 pubmed
    Previous studies have shown that antigens from various life-cycle stages of Ascaris suum can induce host-protective immunity against challenge infections with infective eggs of A. suum...
  70. Islam M, Miyoshi T, Yamada M, Alim M, Huang X, Motobu M, et al. Fluoride exposure inhibits protein expression and enzyme activity in the lung-stage larvae of Ascaris suum. Parasitology. 2006;133:497-508 pubmed
    Sodium fluoride (NaF) is an anion that has been previously shown to block the moulting process of Ascaris suum larvae. This study describes moulting and development-specific protein expression profiles of A...
  71. McConchie B, Norris H, Bundoc V, Trivedi S, Boesen A, Urban J, et al. Ascaris suum-derived products suppress mucosal allergic inflammation in an interleukin-10-independent manner via interference with dendritic cell function. Infect Immun. 2006;74:6632-41 pubmed
    We have previously demonstrated that protection from allergic inflammation by Ascaris suum infection was characterized by a global increase in interleukin-10 (IL-10) and the development of protective CD4(+)/CD25(+) T cells (L. Schopf, S...
  72. Slotved H, Eriksen L, Murrell K, Nansen P. Comparison of methods for recovery of Ascaris suum larvae from tissues of mice. Int J Parasitol. 1997;27:1305-10 pubmed
    Experiments were undertaken to compare procedures for isolating Ascaris suum from mice. A standardised intragastric procedure for inoculation of A. suum eggs, which had a very low interdose variation (S.D. = 6...
  73. Serrano F, Reina D, Frontera E, Roepstorff A, Navarrete -. Resistance against migrating ascaris suum larvae in pigs immunized with infective eggs or adult worm antigens. Parasitology. 2001;122:699-707 pubmed
    Resistance to Ascaris suum infections was investigated in 8- and 15-week-old Iberian pigs. Groups of 3 or 5 pigs were immunized weekly for 6 weeks with antigens of adult A...
  74. Pires R, Oshiro T, Itami D, Fernandes I, Macedo Soares M. Production and characterization of a monoclonal antibody against an Ascaris suum allergenic component. Braz J Med Biol Res. 2001;34:1033-6 pubmed
    b>Ascaris suum allergenic components (PIII) separated by gel filtration chromatography of an adult worm extract were used to immunize BALB/c mice...
  75. Kulkarni G, Sabnis N, Harris B. Cloning, expression, and purification of fumarase from the parasitic nematode Ascaris suum. Protein Expr Purif. 2004;33:209-13 pubmed
    ..fumarase, an enzyme catalyzing reversible hydration of fumarate to L-malate, from the parasitic roundworm Ascaris suum, has been cloned, sequenced, over-expressed in Escherichia coli, and purified...
  76. Pöltl G, Kerner D, Paschinger K, Wilson I. N-glycans of the porcine nematode parasite Ascaris suum are modified with phosphorylcholine and core fucose residues. FEBS J. 2007;274:714-26 pubmed
    ..Previous studies with the porcine roundworm parasite Ascaris suum have focused on its glycosphingolipids, which were found, in part, to be modified by phosphorylcholine...
  77. Dawson H, Solano Aguilar G, Beal M, Beshah E, Vangimalla V, Jones E, et al. Localized Th1-, Th2-, T regulatory cell-, and inflammation-associated hepatic and pulmonary immune responses in Ascaris suum-infected swine are increased by retinoic acid. Infect Immun. 2009;77:2576-87 pubmed publisher
    Pigs infected with Ascaris suum or controls were given 100 microg (low-dose) or 1,000 microg (high-dose) all-trans retinoic acid (ATRA)/kg body weight in corn oil or corn oil alone per os on days after inoculation (DAI) -1, +1, and +3 ..
  78. Masure D, Vlaminck J, Wang T, Chiers K, van den Broeck W, Vercruysse J, et al. A role for eosinophils in the intestinal immunity against infective Ascaris suum larvae. PLoS Negl Trop Dis. 2013;7:e2138 pubmed publisher
    The aim of this study was to explore the mechanisms of resistance against invading Ascaris suum larvae in pigs. Pigs received a low dose of 100 A. suum eggs daily for 14 weeks...
  79. Boes J, Eriksen L, Nansen P. Embryonation and infectivity of Ascaris suum eggs isolated from worms expelled by pigs treated with albendazole , pyrantel pamoate, ivermectin or piperazine dihydrochloride. Vet Parasitol. 1998;75:181-90 pubmed
    The effect of anthelmintic treatment of pigs on the embryonation and infectivity of Ascaris suum eggs isolated from expelled worms was investigated...
  80. Davis R, Stretton A. Structure-activity relationships of 18 endogenous neuropeptides on the motor nervous system of the nematode Ascaris suum. Peptides. 2001;22:7-23 pubmed
    ..This study of the motor nervous system of the parasitic nematode Ascaris suum describes the physiological effects of a family of 18 endogenous Ascaris FMRFamide-like peptides (AF peptides) ..
  81. Bascal Z, Cunningham J, Holden Dye L, O SHEA M, Walker R. Characterization of a putative nitric oxide synthase in the neuromuscular system of the parasitic nematode, Ascaris suum. Parasitology. 2001;122:219-31 pubmed
    In this paper we report on the biochemical presence of nitric oxide synthase (NOS)-like activity in Ascaris suum tissue and examine the pharmacological effect of NO donors on A. suum muscle strip preparation...
  82. Moffett C, Beckett A, Mousley A, Geary T, Marks N, Halton D, et al. The ovijector of Ascaris suum: multiple response types revealed by Caenorhabditis elegans FMRFamide-related peptides. Int J Parasitol. 2003;33:859-76 pubmed
    ..Peptides from five flp genes (1, 6, 8, 9 and 14) are known to modulate the ovijector of Ascaris suum in vitro...
  83. Sakurai M, Ohtsuki T, Suzuki T, Watanabe K. Unusual usage of wobble modifications in mitochondrial tRNAs of the nematode Ascaris suum. FEBS Lett. 2005;579:2767-72 pubmed
    ..tRNAs with unusual secondary structures, post-transcriptional modifications at wobble positions of Ascaris suum mitochondrial tRNAs corresponding to two-codon families ending with a purine were analyzed...
  84. Itami D, Oshiro T, Araujo C, Perini A, Martins M, Macedo M, et al. Modulation of murine experimental asthma by Ascaris suum components. Clin Exp Allergy. 2005;35:873-9 pubmed
    We have recently isolated two distinct components from Ascaris suum adult worms with different effects on the immune system: the allergenic protein of A. suum (APAS-3), which induces IgE antibody production, and suppressive protein of A...
  85. Matsumoto Y, Suzuki S, Nozoye T, Yamakawa T, Takashima Y, Arakawa T, et al. Oral immunogenicity and protective efficacy in mice of transgenic rice plants producing a vaccine candidate antigen (As16) of Ascaris suum fused with cholera toxin B subunit. Transgenic Res. 2009;18:185-92 pubmed publisher
    ..Here, we evaluated the rice Oryza sativa for production of As16-an antigen protective against the roundworm Ascaris suum. The antigen was produced as a chimeric protein fused with cholera toxin B subunit (CTB), and its expression ..
  86. Williamson S, Robertson A, Brown L, Williams T, Woods D, Martin R, et al. The nicotinic acetylcholine receptors of the parasitic nematode Ascaris suum: formation of two distinct drug targets by varying the relative expression levels of two subunits. PLoS Pathog. 2009;5:e1000517 pubmed publisher
    ..b>Ascaris suum is a gastrointestinal parasite of pigs; in addition to its veterinary significance it is a good model of the ..
  87. Labare M, Soohoo H, Kim D, Tsoi K, Liotta J, Bowman D. Ineffectiveness of a quaternary ammonium salt and povidone-iodine for the inactivation of Ascaris suum eggs. Am J Infect Control. 2013;41:360-1 pubmed publisher
    ..a quaternary ammonium salt and povidone-iodine, were tested for effectiveness against unembryonated Ascaris suum eggs...
  88. Pedersen S, Saeed I, Friis H, Michaelsen K. Effect of iron deficiency on Trichuris suis and Ascaris suum infections in pigs. Parasitology. 2001;122:589-98 pubmed
    ..10-week-old pigs fed a low or a normal iron diet were infected with both Trichuris suis (4500 eggs) and Ascaris suum (1200 eggs)...
  89. Miao L, Vanderlinde O, Stewart M, Roberts T. Retraction in amoeboid cell motility powered by cytoskeletal dynamics. Science. 2003;302:1405-7 pubmed
    ..Therefore, cytoskeletal dynamics alone, unassisted by conventional motors, are able to generate both of these central components of amoeboid locomotion...
  90. Islam M, Miyoshi T, Yokomizo Y, Tsuji N. The proteome expression patterns in adult Ascaris suum under exposure to aerobic/anaerobic environments analyzed by two-dimensional electrophoresis. Parasitol Res. 2004;93:96-101 pubmed
    We investigated the protein expression patterns (the proteome) in adult Ascaris suum under exposure to aerobic and anaerobic environments in vitro using two-dimensional polyacrylamide gel electrophoresis. Adult A...
  91. Frontera E, Alcaide M, Dominguez Alpizar J, Boes J, Reina D, Navarrete I. Evidence of interaction between Ascaris suum and Metastrongylus apri in experimentally infected pigs. Vet Parasitol. 2005;127:295-301 pubmed
    A study has been carried out with the aim to determine possible interactions between Ascaris suum and Metastrongylus apri under experimentally infected pigs. Twenty-eight Iberian pigs were allocated into four groups...
  92. Nejsum P, Frydenberg J, Roepstorff A, Parker E. Population structure in Ascaris suum (Nematoda) among domestic swine in Denmark as measured by whole genome DNA fingerprinting. Hereditas. 2005;142:7-14 pubmed
    We here analyze the population structure in the pig roundworm, Ascaris suum, among domestic pigs in Denmark using a whole-genome DNA fingerprinting technique, "amplified fragment length polymorphism" (AFLP) analysis...