anisakis

Summary

Summary: A genus of nematodes of the superfamily ASCARIDOIDEA. Its organisms are found in the stomachs of marine animals and birds. Human infection occurs by ingestion of raw fish that contain larvae.

Top Publications

  1. Pampiglione S, Rivasi F, Criscuolo M, De Benedittis A, Gentile A, Russo S, et al. Human anisakiasis in Italy: a report of eleven new cases. Pathol Res Pract. 2002;198:429-34 pubmed
    ..cases, the diagnosis was based on histological findings: an eosinophilic granuloma associated with a larva of Anisakis sp. For one of them, the larva was removed from the stomach by endoscopy...
  2. Anadón A, Rodriguez E, Gárate M, Cuellar C, Romaris F, Chivato T, et al. Diagnosing human anisakiasis: recombinant Ani s 1 and Ani s 7 allergens versus the UniCAP 100 fluorescence enzyme immunoassay. Clin Vaccine Immunol. 2010;17:496-502 pubmed publisher
    ..for serodiagnosis of human anisakiasis either are poorly specific or do not include some of the most relevant Anisakis allergens. The use of selected recombinant allergens may improve serodiagnosis...
  3. Umehara A, Kawakami Y, Ooi H, Uchida A, Ohmae H, Sugiyama H. Molecular identification of Anisakis type I larvae isolated from hairtail fish off the coasts of Taiwan and Japan. Int J Food Microbiol. 2010;143:161-5 pubmed publisher
    ..The parasites most frequently associated with the disease in humans are categorized as Anisakis type I, which comprise several species of the genus Anisakis...
  4. Choi S, Kim J, Jo J, Cho M, Yu H, Cha H, et al. Anisakis simplex larvae: infection status in marine fish and cephalopods purchased from the Cooperative Fish Market in Busan, Korea. Korean J Parasitol. 2011;49:39-44 pubmed publisher
    The infection status of marine fish and cephalopods with Anisakis simplex third stage larva (L3) was studied over a period of 1 year...
  5. Armentia A, Lombardero M, Callejo A, Martín Santos J, Gil F, Vega J, et al. Occupational asthma by Anisakis simplex. J Allergy Clin Immunol. 1998;102:831-4 pubmed
    No cases of occupational asthma caused by the inhalation of antigens from Anisakis simplex have been published...
  6. Arias Diaz J, Zuloaga J, Vara E, Balibrea J, Balibrea J. Efficacy of albendazole against Anisakis simplex larvae in vitro. Dig Liver Dis. 2006;38:24-6 pubmed
    ..To study the in vitro activity of different concentrations of albendazole against Anisakis simplex larvae under different media pH. A...
  7. Umehara A, Kawakami Y, Araki J, Uchida A. Multiplex PCR for the identification of Anisakis simplex sensu stricto, Anisakis pegreffii and the other anisakid nematodes. Parasitol Int. 2008;57:49-53 pubmed
    A multiplex PCR method was established for the rapid identification of Anisakis simplex sensu stricto, A. pegreffii, A. physeteris, Pseudoterranova decipiens, Contracaecum osculatum and Hysterothylacium aduncum...
  8. Anadón A, Romaris F, Escalante M, Rodriguez E, Garate T, Cuellar C, et al. The Anisakis simplex Ani s 7 major allergen as an indicator of true Anisakis infections. Clin Exp Immunol. 2009;156:471-8 pubmed publisher
    Ani s 7 is currently the most important excretory/secretory (ES) Anisakis simplex allergen, as it is the only one recognized by 100% of infected patients...
  9. Del Carmen Romero M, Valero A, Navarro Moll M, Martin Sanchez J. Experimental comparison of pathogenic potential of two sibling species Anisakis simplex s.s. and Anisakis pegreffii in Wistar rat. Trop Med Int Health. 2013;18:979-84 pubmed publisher
    There are little data available on the pathology caused by the sibling species Anisakis simplex s.s. and Anisakis pegreffii. The differences shown in their ability to penetrate the muscle of fish may also be manifested in humans...

More Information

Publications130 found, 100 shown here

  1. Shih H, Ku C, Wang C. Anisakis simplex (Nematoda: Anisakidae) third-stage larval infections of marine cage cultured cobia, Rachycentron canadum L., in Taiwan. Vet Parasitol. 2010;171:277-85 pubmed publisher
    The first confirmed case of Anisakis simplex infection of the marine cage cobia, Rachycentron canadum (L.), was recorded in Taiwan...
  2. Kijewska A, Dzido J, Rokicki J. Mitochondrial DNA of Anisakis simplex s.s. as a potential tool for differentiating populations. J Parasitol. 2009;95:1364-70 pubmed publisher
    b>Anisakis simplex s.s...
  3. Garcia Hernandez P, Rodero M, Cuellar C. Study of the effect of Anisakis simplex larval products on the early and late components in the classical complement pathway. J Parasitol. 2009;95:240-1 pubmed publisher
    ..In previous studies, we have reported that the larval products (crude extract [CE] and excretory-secretory [ES]) of Anisakis simplex showed a dose-dependent inhibition of the lysis mediated by classical (CP) and alternative pathways (AP) ..
  4. Daschner A, Cuellar C, Rodero M. The Anisakis allergy debate: does an evolutionary approach help?. Trends Parasitol. 2012;28:9-15 pubmed publisher
    ..The experience with the fish parasite Anisakis simplex-associated allergic features still nurtures an open debate on the necessity of larvae being alive to ..
  5. Shimakura K, Miura H, Ikeda K, Ishizaki S, Nagashima Y, Shirai T, et al. Purification and molecular cloning of a major allergen from Anisakis simplex. Mol Biochem Parasitol. 2004;135:69-75 pubmed
    A heat-stable allergen with a molecular weight of 21 k was purified from larvae of the nematode Anisakis simplex by gel filtration, anion-exchange FPLC and reverse-phase HPLC...
  6. Cuellar C, Daschner A, Valls A, De Frutos C, Fernández Fígares V, Anadón A, et al. Ani s 1 and Ani s 7 recombinant allergens are able to differentiate distinct Anisakis simplex-associated allergic clinical disorders. Arch Dermatol Res. 2012;304:283-8 pubmed publisher
    ..In Anisakis simplex sensitisation associated chronic urticaria (CU+), clinical evaluation of possible ..
  7. Pontes T, D Amelio S, Costa G, Paggi L. Molecular characterization of larval anisakid nematodes from marine fishes of Madeira by a PCR-based approach, with evidence for a new species. J Parasitol. 2005;91:1430-4 pubmed
    ..Three distinct species were identified in A. carbo, namely Anisakis simplex sensu srricto, Anisakis pegreffii, and Anisakis ziphidarum; 5 in S. japonicus, i.e., A. simplex s.s., A...
  8. Navarro Moll M, Romero M, Montilla M, Valero A. In vitro and in vivo activity of three sesquiterpenes against L(3) larvae of Anisakis type I. Exp Parasitol. 2011;127:405-8 pubmed publisher
    In order to investigate the possible use of terpenic derivatives to treat anisakiasis caused by L(3) larvae of Anisakis, we studied the in vitro and in vivo larvicidal activity of three sesquiterpenes (nerolidol, farnesol and elemol)...
  9. Falcao H, Lunet N, Neves E, Iglesias I, Barros H. Anisakis simplex as a risk factor for relapsing acute urticaria: a case-control study. J Epidemiol Community Health. 2008;62:634-7 pubmed publisher
    IgE-mediated hypersensitivity reactions to Anisakis simplex have been described after ingestion of fish, suggesting that sensitisation to this parasite may induce acute urticaria and anaphylaxis...
  10. Klimpel S, Kellermanns E, Palm H. The role of pelagic swarm fish (Myctophidae: Teleostei) in the oceanic life cycle of Anisakis sibling species at the Mid-Atlantic Ridge, Central Atlantic. Parasitol Res. 2008;104:43-53 pubmed publisher
    ..cestodes (Scolex pleuronectis) from the intestine, and genetically identified larval anisakid nematodes of Anisakis simplex (s.s.) from the body cavity. No further Anisakis sibling species could be identified...
  11. Lin R, Chen C, Lee J, Lu C, Chung L, Yen C. Larvicidal constituents of Zingiber officinale (ginger) against Anisakis simplex. Planta Med. 2010;76:1852-8 pubmed publisher
    ..Zingiberaceae (ginger), against Anisakis simplex. The above compounds kill or reduce spontaneous movement in A. simplex larvae...
  12. Iglesias L, Valero A, Benitez R, Adroher F. In vitro cultivation of anisakis simplex: pepsin increases survival and moulting from fourth larval to adult stage. Parasitology. 2001;123:285-91 pubmed
    This paper describes the in vitro cultivation of the 3rd-larval stage (L3) of Anisakis simplex to adulthood in a much simpler and easier to prepare medium than those described to date. The adult males obtained are between 3.8 and 6...
  13. Martin Sanchez J, Artacho Reinoso M, Díaz Gavilán M, Valero López A. Structure of Anisakis simplex s.l. populations in a region sympatric for A. pegreffii and A. simplex s.s. Absence of reproductive isolation between both species. Mol Biochem Parasitol. 2005;141:155-62 pubmed
    ..The fourth is comprised of a single specimen of L3, identified both by PCR-RFLP and by RAPD-PCR as a new genotype. ..
  14. Mattiucci S, Nascetti G, Dailey M, Webb S, Barros N, Cianchi R, et al. Evidence for a new species of Anisakis Dujardin, 1845: morphological description and genetic relationships between congeners (Nematoda: Anisakidae). Syst Parasitol. 2005;61:157-71 pubmed
    In the present study, a new biological species of Anisakis Dujardin, 1845, was detected in Kogia breviceps and K...
  15. Lozano M, Martín H, Díaz S, Mañas A, Valero L, Campos B. Cross-reactivity between antigens of Anisakis simplex s.l. and other ascarid nematodes. Parasite. 2004;11:219-23 pubmed
    A study of the cross-reactivity among somatic and excretory-secretory antigens of the third stage larvae of Anisakis simplex s.l. and somatic antigens of other ascarid nematodes (Ascaris lumbricoides, A...
  16. Guarneri F, Guarneri C, Benvenga S. Cross-reactivity of Anisakis simplex: possible role of Ani s 2 and Ani s 3. Int J Dermatol. 2007;46:146-50 pubmed
    b>Anisakis simplex is a fish parasite that can cause allergy in humans. The multiple cross-reactivities of this nematode make diagnostic tests for allergy unreliable, because of frequent false-positive results...
  17. Nieuwenhuizen N, Herbert D, Brombacher F, Lopata A. Differential requirements for interleukin (IL)-4 and IL-13 in protein contact dermatitis induced by Anisakis. Allergy. 2009;64:1309-18 pubmed publisher
    Exposure to antigens of the fish parasite Anisakis is associated with the development of protein contact dermatitis in seafood-processing workers...
  18. Abollo E, D Amelio S, Pascual S. Fitness of the marine parasitic nematode Anisakis simplex s. str. in temperate waters of the NE Atlantic. Dis Aquat Organ. 2001;45:131-9 pubmed
    In temperate waters of the NE Atlantic, third-stage larvae of Anisakis simplex sensu stricto collected from 3 paratenic host species were identified by restriction fragment length polymorphisms...
  19. López Sáez M, Zubeldia J, Caloto M, Olalde S, Pelta R, Rubio M, et al. Is Anisakis simplex responsible for chronic urticaria?. Allergy Asthma Proc. 2003;24:339-45 pubmed
    ..Recently, sensitization to the parasite larva Anisakis simplex has been described as the cause of acute urticaria and anaphylaxis...
  20. Marques J, Cabral H, Busi M, D Amelio S. Molecular identification of Anisakis species from Pleuronectiformes off the Portuguese coast. J Helminthol. 2006;80:47-51 pubmed
    Anisakid nematodes belonging to the Anisakis simplex complex are highly prevalent in several fish species off the coast of Portugal and are an important zoonotic problem in the Iberian Peninsula...
  21. Umehara A, Kawakami Y, Araki J, Uchida A. Molecular identification of the etiological agent of the human anisakiasis in Japan. Parasitol Int. 2007;56:211-5 pubmed
    b>Anisakis simplex complex presently comprises three sibling species, A. simplex sensu stricto, A. pegreffii and A. simplex C. A. simplex is a common parasite in fishes and cephalopods and capable of causing anisakiasis in humans...
  22. Farjallah S, Busi M, Mahjoub M, Slimane B, Paggi L, Said K, et al. Molecular characterization of larval anisakid nematodes from marine fishes off the Moroccan and Mauritanian coasts. Parasitol Int. 2008;57:430-6 pubmed publisher
    A total of 242 larval forms of Anisakis collected from marine fishes at different sites off the Moroccan and Mauritanian coasts, recognised as belonging to Type I and Type II larvae, were identified by PCR-RFLP (Polymerase Chain Reaction-..
  23. Frezzolini A, Cadoni S, de Pita O. Usefulness of the CD63 basophil activation test in detecting Anisakis hypersensitivity in patients with chronic urticaria: diagnosis and follow-up. Clin Exp Dermatol. 2010;35:765-70 pubmed publisher
    ..basophil activation test (BAT) has been recently described as a useful in vitro tool for diagnosis of allergy to Anisakis species in patients with acute urticaria...
  24. Baldwin R, Rew M, Johansson M, Banks M, Jacobson K. Population structure of three species of Anisakis nematodes recovered from Pacific sardines (Sardinops sagax) distributed throughout the California Current system. J Parasitol. 2011;97:545-54 pubmed publisher
    ..Despite information on the global distribution of Anisakis species, there is little information on the genetic diversity and population structure of this genus, which could ..
  25. Choi S, Lee J, Kim M, Hur G, Shin S, Park H. The clinical characteristics of Anisakis allergy in Korea. Korean J Intern Med. 2009;24:160-3 pubmed publisher
    ..Although several groups have reported a gastrointestinal Anisakis allergy among people in Spain and Japan, our report is the first to summarize the clinical features of 10 ..
  26. Yasunaga H, Horiguchi H, Kuwabara K, Hashimoto H, Matsuda S. Clinical features of bowel anisakiasis in Japan. Am J Trop Med Hyg. 2010;83:104-5 pubmed publisher
    ..5%) patients. Fourteen (7.0%) cases underwent open surgery. Three (1.5%) underwent colonoscopic removal of Anisakis larvae. The average length of stay in the hospital was 9.6 days...
  27. Falcao H, Lunet N, Neves E, Barros H. Do only live larvae cause Anisakis simplex sensitization?. Allergy. 2002;57:44 pubmed
  28. Abe N, Ohya N, Yanagiguchi R. Molecular characterization of Anisakis pegreffii larvae in Pacific cod in Japan. J Helminthol. 2005;79:303-6 pubmed
    It is now recognized that the morphospecies Anisakis simplex is not a single species but a complex composed of three sibling species, A. simplex sensu stricto, A. pegreffii and A. simplex C. In Japan, A...
  29. Daschner A, Pascual C. Anisakis simplex: sensitization and clinical allergy. Curr Opin Allergy Clin Immunol. 2005;5:281-5 pubmed
    Whereas gastric anisakiasis has been known for several decades, the implications of Anisakis simplex-related allergic disorders had not been thoroughly studied until the late 1990s...
  30. Kobayashi Y, Shimakura K, Ishizaki S, Nagashima Y, Shiomi K. Purification and cDNA cloning of a new heat-stable allergen from Anisakis simplex. Mol Biochem Parasitol. 2007;155:138-45 pubmed
    The nematode Anisakis simplex is a representative parasite for marine animals and occasionally causes not only anisakiasis but also allergic reactions in sensitized subjects...
  31. Suzuki J, Murata R, Hosaka M, Araki J. Risk factors for human Anisakis infection and association between the geographic origins of Scomber japonicus and anisakid nematodes. Int J Food Microbiol. 2010;137:88-93 pubmed publisher
    It has been reported that nearly all cases of anisakiasis in Japan are caused by Anisakis simplex sensu stricto...
  32. Rodriguez E, Anadón A, García Bodas E, Romaris F, Iglesias R, Garate T, et al. Novel sequences and epitopes of diagnostic value derived from the Anisakis simplex Ani s 7 major allergen. Allergy. 2008;63:219-25 pubmed publisher
    b>Anisakis simplex allergens may cause severe allergic reactions in infected patients...
  33. Hochberg N, Hamer D. Anisakidosis: Perils of the deep. Clin Infect Dis. 2010;51:806-12 pubmed publisher
    Anisakidosis, human infection with nematodes of the family Anisakidae, is caused most commonly by Anisakis simplex and Pseudoterranova decipiens...
  34. Romero M, Valero A, Martin Sanchez J, Navarro Moll M. Activity of Matricaria chamomilla essential oil against anisakiasis. Phytomedicine. 2012;19:520-3 pubmed publisher
    ..and the virtual absence of effective treatments have prompted the search for new active compounds against Anisakis L(3) larvae...
  35. Valiñas B, Lorenzo S, Eiras A, Figueiras A, Sanmartin M, Ubeira F. Prevalence of and risk factors for IgE sensitization to Anisakis simplex in a Spanish population. Allergy. 2001;56:667-71 pubmed
    ..in fish tissues, and that ingestion of homemade boquerones (anchovies [Engraulis encrasicholus] in vinegar), and to a much lesser extent of undercooked fish, are the main risk factors for IgE sensitization to Anisakis in this region.
  36. Strømnes E, Andersen K. Growth of whaleworm (Anisakis simplex, Nematodes, Ascaridoidea, Anisakidae) third-stage larvae in paratenic fish hosts. Parasitol Res. 2003;89:335-41 pubmed
    The growth of Anisakis simplex L3 larvae in the three paratenic hosts saithe ( Pollachius virens), cod (Gadus morhua) and redfish (Sebastes marinus) was studied based on material collected off the island of Vega on the west coast of ..
  37. Daschner A, De Frutos C, Valls A, Vega F. Anisakis simplex sensitization-associated urticaria: short-lived immediate type or prolonged acute urticaria. Arch Dermatol Res. 2010;302:625-9 pubmed publisher
    ..in immunologic features in immediate type urticaria versus prolonged acute urticaria within the model of Anisakis simplex (A. simplex) sensitization-associated urticaria...
  38. Karl H, Baumann F, Ostermeyer U, Kuhn T, Klimpel S. Anisakis simplex (s.s.) larvae in wild Alaska salmon: no indication of post-mortem migration from viscera into flesh. Dis Aquat Organ. 2011;94:201-9 pubmed publisher
    The prevalence, mean intensity and distribution of Anisakis nematode third-stage larvae (L3) in the muscle and viscera of wild-caught chum salmon Oncorhynchus keta, pink salmon O. gorbuscha and sockeye salmon O...
  39. Caballero M, Umpierrez A, Pérez Piñar T, Moneo I, de Burgos C, Asturias J, et al. Anisakis simplex recombinant allergens increase diagnosis specificity preserving high sensitivity. Int Arch Allergy Immunol. 2012;158:232-40 pubmed publisher
    So far, the frequency of Anisakis simplex-specific IgE antibodies has been determined by skin prick tests (SPTs) and the ImmunoCAP system...
  40. Mladineo I, Simat V, Miletić J, Beck R, Poljak V. Molecular identification and population dynamic of Anisakis pegreffii (Nematoda: Anisakidae Dujardin, 1845) isolated from the European anchovy (Engraulis encrasicolus L.) in the Adriatic Sea. Int J Food Microbiol. 2012;157:224-9 pubmed publisher
    ..In Croatia, it is marketed fresh, frozen, salted or marinated and mainly exported to Italy and Spain, however Anisakis sp. larval infection is frequently the reason for border rejection...
  41. Manfredi M, Crosa G, Galli P, Ganduglia S. Distribution of Anisakis simplex in fish caught in the Ligurian Sea. Parasitol Res. 2000;86:551-3 pubmed
    ..5 fish species were sampled in the western coastal area of the Mediterranean Sea and examined for the presence of Anisakis simplex larvae in the body cavity, muscle, and viscera. A...
  42. Park H, Cho M, Park M, Kang S, Kim Y, Kim K, et al. A 24 kDa excretory-secretory protein of Anisakis simplex larvae could elicit allergic airway inflammation in mice. Korean J Parasitol. 2011;49:373-80 pubmed publisher
    We have reported that a 24 kDa protein (22U homologous; As22U) of Anisakis simplex larvae could elicit several Th2-related chemokine gene expressions in the intestinal epithelial cell line which means that As22U may play a role as an ..
  43. Johansson E, Aponno M, Lundberg M, van Hage Hamsten M. Allergenic cross-reactivity between the nematode Anisakis simplex and the dust mites Acarus siro, Lepidoglyphus destructor, Tyrophagus putrescentiae, and Dermatophagoides pteronyssinus. Allergy. 2001;56:660-6 pubmed
    The nematode Anisakis simplex is a common parasite on fish and other seafood. It is considered to be a food allergen and to induce IgE-mediated reactions. Allergenic cross-reactivity between A...
  44. Arlian L, Morgan M, Quirce S, Marañón F, Fernandez Caldas E. Characterization of allergens of Anisakis simplex. Allergy. 2003;58:1299-303 pubmed
    b>Anisakis simplex is an intestinal parasite of sea mammals. The larvae infect crustaceans, cephalopods and fish. Humans may consume A. simplex third stage larvae (L3) when eating infected raw or under-cooked fish...
  45. Navarro M, Noguera M, Romero M, Montilla M, González de Selgas J, Valero A. Anisakis simplex s.l.: Larvicidal activity of various monoterpenic derivatives of natural origin against L3 larvae in vitro and in vivo. Exp Parasitol. 2008;120:295-9 pubmed publisher
    This paper describes the activity against Anisakis simplex s.l. L(3) larvae of six monoterpenic derivatives obtained from different essential oils, (alpha-pinene, beta-pinene, ocimene, myrcene, geranyl acetate, and cineole)...
  46. Mattiucci S, Paoletti M, Webb S. Anisakis nascettii n. sp. (Nematoda: Anisakidae) from beaked whales of the southern hemisphere: morphological description, genetic relationships between congeners and ecological data. Syst Parasitol. 2009;74:199-217 pubmed publisher
    A new anisakid nematode, Anisakis nascettii n. sp., is described from beaked whales Mesoplodon spp. off the coast of New Zealand and South Africa...
  47. Quiazon K, Yoshinaga T, Ogawa K. Experimental challenge of Anisakis simplex sensu stricto and Anisakis pegreffii (Nematoda: Anisakidae) in rainbow trout and olive flounder. Parasitol Int. 2011;60:126-31 pubmed publisher
    The third-stage larvae of Anisakis simplex sensu lato (s.l.) are found in many marine fishes. To ensure food safety, it is important to determine whether these larvae are present in the body muscle of commercial fish species...
  48. Moneo I, Caballero M, Rodriguez Perez R, Rodriguez Mahillo A, Gonzalez Munoz M. Sensitization to the fish parasite Anisakis simplex: clinical and laboratory aspects. Parasitol Res. 2007;101:1051-5 pubmed
    Hypersensitivity to Anisakis simplex is a worldwide medical problem...
  49. Mattiucci S, Nascetti G. Genetic diversity and infection levels of anisakid nematodes parasitic in fish and marine mammals from Boreal and Austral hemispheres. Vet Parasitol. 2007;148:43-57 pubmed
    ..This suggests that anisakid nematodes, and their levels of genetic diversity may be suitable indicators of the integrity of marine food webs and of the general biodiversity of a marine ecosystem. ..
  50. Arizono N, Yamada M, Tegoshi T, Yoshikawa M. Anisakis simplex sensu stricto and Anisakis pegreffii: biological characteristics and pathogenetic potential in human anisakiasis. Foodborne Pathog Dis. 2012;9:517-21 pubmed publisher
    ..most common fishborne helminthic diseases in Japan, which is contracted by ingesting the larvae of the nematode Anisakis spp. carried by marine fish. Anisakis simplex sensu stricto (s.s.) and A...
  51. Kobayashi Y, Ohsaki K, Ikeda K, Kakemoto S, Ishizaki S, Shimakura K, et al. Identification of novel three allergens from Anisakis simplex by chemiluminescent immunoscreening of an expression cDNA library. Parasitol Int. 2011;60:144-50 pubmed publisher
    b>Anisakis simplex is a representative nematode parasitizing marine organisms, such as fish and squids, and causes not only anisakiasis but also IgE-mediated allergy. Although 10 kinds of proteins have so far been identified as A...
  52. Couture C, Measures L, Gagnon J, Desbiens C. Human intestinal anisakiosis due to consumption of raw salmon. Am J Surg Pathol. 2003;27:1167-72 pubmed
    ..follows consumption of raw or insufficiently pickled, salted, smoked, or cooked wild marine fish infected with Anisakis sp. larvae...
  53. Farjallah S, Slimane B, Busi M, Paggi L, Amor N, Blel H, et al. Occurrence and molecular identification of Anisakis spp. from the North African coasts of Mediterranean Sea. Parasitol Res. 2008;102:371-9 pubmed
    Larval forms of the genus Anisakis were reported infecting several fish species from the North African coasts of central Mediterranean Sea...
  54. Iñiguez A, Santos C, Vicente A. Genetic characterization of Anisakis typica and Anisakis physeteris from marine mammals and fish from the Atlantic Ocean off Brazil. Vet Parasitol. 2009;165:350-6 pubmed publisher
    Until now, Anisakis typica has been the sole anisakid identified by means of genetic markers from the Atlantic Ocean off Brazil. In this study we developed, and applied to larvae and adults, an A...
  55. Lopez Serrano M, Gomez A, Daschner A, Moreno Ancillo A, de Parga J, Caballero M, et al. Gastroallergic anisakiasis: findings in 22 patients. J Gastroenterol Hepatol. 2000;15:503-6 pubmed
    ..b>Anisakis simplex can cause allergic reactions in sensitized patients as a result of its parasitism in the gastrointestinal ..
  56. Quiazon K, Yoshinaga T, Ogawa K, Yukami R. Morphological differences between larvae and in vitro-cultured adults of Anisakis simplex (sensu stricto) and Anisakis pegreffii (Nematoda: Anisakidae). Parasitol Int. 2008;57:483-9 pubmed publisher
    Proper identification of Anisakis species infecting host fishes is very important to both human health and fish disease diagnosis...
  57. Cho M, Ahn S, Kim D, Yu H. Parasite excretory-secretory proteins elicit TRIF dependent CXCL1 and IL-6 mediated allergic inflammation. Parasite Immunol. 2010;32:354-60 pubmed publisher
    ..In this study, we isolated the excretory-secretory (ES) proteins from Anisakis simplex (sea mammal intestinal parasite) third stage larva...
  58. Setyobudi E, Jeon C, Lee C, Seong K, Kim J. Occurrence and identification of Anisakis spp. (Nematoda: Anisakidae) isolated from chum salmon (Oncorhynchus keta) in Korea. Parasitol Res. 2011;108:585-92 pubmed publisher
    ..analysis of PCR-RFLP and sequencing of mitochondrial DNA cox2 gene markers, these nematodes were identified as Anisakis simplex (sensu stricto) third-stage larvae...
  59. Audicana M, Ansotegui I, de Corres L, Kennedy M. Anisakis simplex: dangerous--dead and alive?. Trends Parasitol. 2002;18:20-5 pubmed
    The risk of infection with Anisakis simplex and related parasites of fish has been recognized for some time, but it is now emerging that ingestion of material from dead parasites in food is also potentially dangerous...
  60. Nieuwenhuizen N, Lopata A, Jeebhay M, Herbert D, Robins T, Brombacher F. Exposure to the fish parasite Anisakis causes allergic airway hyperreactivity and dermatitis. J Allergy Clin Immunol. 2006;117:1098-105 pubmed
    Several case reports show allergy and anaphylactic reactions to the fish parasite Anisakis in the domestic and occupational setting. Further research is needed on the prevalence and mechanisms of disease.
  61. Cuellar C, Perteguer M, Rodero M. Presence of IL-4-like molecules in larval excretory-secretory products and crude extracts from Anisakis simplex. Scand J Immunol. 2001;53:483-8 pubmed
    ..The purpose of this study was to investigate the presence of interleukin (IL)-4 in the larval antigens of Anisakis simplex...
  62. Ramos L, Alonso C, Guilarte M, Vilaseca J, Santos J, Malagelada J. Anisakis simplex-induced small bowel obstruction after fish ingestion: preliminary evidence for response to parenteral corticosteroids. Clin Gastroenterol Hepatol. 2005;3:667-71 pubmed
    ..zoonoses, may be acquired by humans after the ingestion of raw marine fish infested with larvae of the nematode Anisakis simplex...
  63. Mattiucci S. Parasites as biological tags in population studies of demersal and pelagic fish species. Parassitologia. 2006;48:23-5 pubmed
    ..Different species of Anisakis and Hysterothylacium were genetically identified by the application of genetic (allozyme) markers...
  64. Iniguez A, Carvalho V, Motta M, Pinheiro D, Vicente A. Genetic analysis of Anisakis typica (Nematoda: Anisakidae) from cetaceans of the northeast coast of Brazil: new data on its definitive hosts. Vet Parasitol. 2011;178:293-9 pubmed publisher
    ..The 18S rDNA gene, ITS1, and specific Anisakis typica ITS regions were amplified by PCR. 18S rDNA and ITS1 region confirmed Anisakis sp...
  65. Abollo E, Gestal C, Pascual S. Anisakis infestation in marine fish and cephalopods from Galician waters: an updated perspective. Parasitol Res. 2001;87:492-9 pubmed
    ..recovered were identified by light microscopy and multilocus electrophoresis as belonging to the species Anisakis simplex sensu stricto and A. pegreffii...
  66. Wharton D, Aalders O. The response of Anisakis larvae to freezing. J Helminthol. 2002;76:363-8 pubmed
    b>Anisakis third stage larvae utilize a variety of fish as intermediate hosts. Uncooked fish are rendered safe for human consumption by freezing...
  67. Nadler S, D Amelio S, Dailey M, Paggi L, Siu S, Sakanari J. Molecular phylogenetics and diagnosis of Anisakis, Pseudoterranova, and Contracaecum from northern Pacific marine mammals. J Parasitol. 2005;91:1413-29 pubmed
    Individual specimens of Anisakis, Pseudoterranova, and Contracaecum collected from marine mammals inhabiting northern Pacific waters were used for comparative diagnostic and molecular phylogenetic analyses...
  68. Yu H, Park S, Lee K, Lee S, Choi S, Ock M, et al. Anisakis simplex: analysis of expressed sequence tags (ESTs) of third-stage larva. Exp Parasitol. 2007;117:51-6 pubmed
    This study analyzed the expressed sequence tags (ESTs) of the third-stage larvae of Anisakis simplex, in an attempt to gain further insight into its genomic expression patterns. An A...
  69. Takei H, Powell S. Intestinal anisakidosis (anisakiosis). Ann Diagn Pathol. 2007;11:350-2 pubmed
    ..A cross section of the larva revealed the internal structures, pathognomonic of Anisakis simplex...
  70. Kijewska A, Dzido J, Shukhgalter O, Rokicki J. Anisakid parasites of fishes caught on the African shelf. J Parasitol. 2009;95:639-45 pubmed publisher
    ..s. and A. pegreffii). Still other sequences represented closely related, but not sibling, species, i.e., Anisakis brevispiculata, A. ziphidarum, and A. physeteris; there were also 2 undescribed anisakid species...
  71. Hoshino C, Narita M. Anisakis simplex-induced anaphylaxis. J Infect Chemother. 2011;17:544-6 pubmed publisher
    In recent years, Anisakis simplex has been shown to be an important etiologic agent responsible for food allergy and for gastrointestinal anisakiasis...
  72. González Díaz H, Muiño L, Anadón A, Romaris F, Prado Prado F, Munteanu C, et al. MISS-Prot: web server for self/non-self discrimination of protein residue networks in parasites; theory and experiments in Fasciola peptides and Anisakis allergens. Mol Biosyst. 2011;7:1938-55 pubmed publisher
    ..experimental and/or theoretical studies of peptides from Fasciola hepatica cathepsin proteases or present on 10 Anisakis simplex allergens (Ani s 1 to Ani s 10)...
  73. Koinari M, Karl S, Elliot A, Ryan U, Lymbery A. Identification of Anisakis species (Nematoda: Anisakidae) in marine fish hosts from Papua New Guinea. Vet Parasitol. 2013;193:126-33 pubmed publisher
    ..They were identified by both light and scanning electron microscopy as Anisakis Type I larvae...
  74. Mattiucci S, Fazii P, De Rosa A, Paoletti M, Megna A, Glielmo A, et al. Anisakiasis and gastroallergic reactions associated with Anisakis pegreffii infection, Italy. Emerg Infect Dis. 2013;19:496-9 pubmed publisher
    Human cases of gastric anisakiasis caused by the zoonotic parasite Anisakis pegreffii are increasing in Italy. The disease is caused by ingestion of larval nematodes in lightly cooked or raw seafood...
  75. Køie M. Experimental infections of copepods and sticklebacks Gasterosteus aculeatus with small ensheathed and large third-stage larvae of Anisakis simplex (Nematoda, Ascaridoidea, Anisakidae). Parasitol Res. 2001;87:32-6 pubmed
    Free-swimming ensheathed larvae of Anisakis simplex were shown experimentally to be ingested by the copepods Oitona similis and Acartia tonsa and by the nauplii of barnacles Balanus sp. The larvae did not grow in the copepod hemocoel...
  76. Shih H. Parasitic helminth fauna of the cutlass fish, Trichiurus lepturus L., and the differentiation of four anisakid nematode third-stage larvae by nuclear ribosomal DNA sequences. Parasitol Res. 2004;93:188-95 pubmed
    ..The following helminths were found: (1) nematodes--Anisakis simplex, Hysterothylacium aduncum, Porrocaecum decipiens, Raphidascaris trichiuri; (2) digeneans--adult ..
  77. Kim K, Eom K, Park J. The complete mitochondrial genome of Anisakis simplex (Ascaridida: Nematoda) and phylogenetic implications. Int J Parasitol. 2006;36:319-28 pubmed publisher
    We determined the nucleotide sequence of the complete mitochondrial genome of the nematode species Anisakis simplex. The genome is circular, 13,916 bp in size and conforms to the general characteristics of nematode mitochondrial DNAs...
  78. Murphy T, Berzano M, O Keeffe S, Cotter D, McEvoy S, Thomas K, et al. Anisakid larvae in Atlantic salmon (Salmo salar L.) grilse and post-smolts: molecular identification and histopathology. J Parasitol. 2010;96:77-82 pubmed publisher
    ..Larvae in the adult and juvenile salmon were identified as Anisakis simplex sensu stricto by PCR amplification and RFLP and sequencing of the ITS gene and PCR amplification and ..
  79. Noguera P, Collins C, Bruno D, Pert C, Turnbull A, McIntosh A, et al. Red vent syndrome in wild Atlantic salmon Salmo salar in Scotland is associated with Anisakis simplex sensu stricto (Nematoda: Anisakidae). Dis Aquat Organ. 2009;87:199-215 pubmed publisher
    ..trutta. High numbers of the nematode Anisakis Type I larvae were found infesting the discrete region of the vent, a localisation that is reported as novel for ..
  80. Pravettoni V, Primavesi L, Piantanida M. Anisakis simplex: current knowledge. Eur Ann Allergy Clin Immunol. 2012;44:150-6 pubmed
    ..undercooked fish or cephalopods contaminated by third stage (13) larvae of the Anisakidae family, in particular Anisakis simplex (As), A. pegreffii and Pseudoterranova decipiens...
  81. Moschella C, Mattiucci S, Mingazzini P, De Angelis G, Assenza M, Lombardo F, et al. Intestinal anisakiasis in Italy: case report. J Helminthol. 2004;78:271-3 pubmed
    A case of intestinal anisakiasis caused by Anisakis sp. larva type I in a woman from Italy who consumed raw marinated anchovies, is reported...
  82. Bernardini R, Mistrello G, Novembre E, Roncarolo D, Zanotta S, Lombardi E, et al. Cross-reactivity between IgE-binding proteins from Anisakis simplex and Dermatophagoides pteronyssinus. Int J Immunopathol Pharmacol. 2005;18:671-5 pubmed
    An association was found between Anisakis simplex (As) and Dermatophagoides pteronyssinus (Dp) sensitization...
  83. Valentini A, Mattiucci S, Bondanelli P, Webb S, Mignucci Giannone A, Colom Llavina M, et al. Genetic relationships among Anisakis species (Nematoda: Anisakidae) inferred from mitochondrial cox2 sequences, and comparison with allozyme data. J Parasitol. 2006;92:156-66 pubmed
    The genetic relationships among 9 taxa of Anisakis Dujardin, 1845 (A. simplex (sensu stricto), A. pegreffii, A. simplex C., A. typica, A. ziphidarum, A. physeteris, A. brevispiculata, A. paggiae, and Anisakis sp...
  84. Kobayashi Y, Ishizaki S, Shimakura K, Nagashima Y, Shiomi K. Molecular cloning and expression of two new allergens from Anisakis simplex. Parasitol Res. 2007;100:1233-41 pubmed
    The nematode Anisakis simplex is a marine parasite that causes allergy as well as anisakiasis. Although five Anisakis allergens have already been identified, immunoblotting studies suggested that unidentified allergens still exist...
  85. Puente P, Anadón A, Rodero M, Romaris F, Ubeira F, Cuellar C. Anisakis simplex: the high prevalence in Madrid (Spain) and its relation with fish consumption. Exp Parasitol. 2008;118:271-4 pubmed
    ..In this work we (a) investigated whether a recently introduced ELISA of Anisakis simplex-specific IgE in serum suffers from cross-reactivity with other common allergens; (b) used this assay to ..
  86. Rodriguez Mahillo A, Gonzalez Munoz M, Gomez Aguado F, Rodriguez Perez R, Corcuera M, Caballero M, et al. Cloning and characterisation of the Anisakis simplex allergen Ani s 4 as a cysteine-protease inhibitor. Int J Parasitol. 2007;37:907-17 pubmed
    b>Anisakis simplex is a nematode that can parasitise humans who eat raw or undercooked fish containing live L3s...
  87. Zhu X, Podolska M, Liu J, Yu H, Chen H, Lin Z, et al. Identification of anisakid nematodes with zoonotic potential from Europe and China by single-strand conformation polymorphism analysis of nuclear ribosomal DNA. Parasitol Res. 2007;101:1703-7 pubmed
    ..single-strand conformation polymorphism (SSCP) were utilized to identify each of three anisakid species [Anisakis simplex (s.l.), Contracaecum osculatum (s.l...
  88. Bahlool Q, Skovgaard A, Kania P, Haarder S, Buchmann K. Microhabitat preference of Anisakis simplex in three salmonid species: immunological implications. Vet Parasitol. 2012;190:489-95 pubmed publisher
    ..Oncorhynchus mykiss, Salmo salar and Salmo trutta, were infected experimentally with the parasitic nematode Anisakis simplex (A...
  89. Perteguer M, Chivato T, Montoro A, Cuellar C, Mateos J, Laguna R. Specific and total IgE in patients with recurrent, acute urticaria caused by Anisakis simplex. Ann Trop Med Parasitol. 2000;94:259-68 pubmed
    ..IgE were investigated in 19 patients thought to have recurrent, acute urticaria caused by sensitization to Anisakis simplex (Dujardin, 1845), before and after they were placed on a fish-free diet...
  90. Mattiucci S, Paggi L, Nascetti G, Portes Santos C, Costa G, Di Beneditto A, et al. Genetic markers in the study of Anisakis typica (Diesing, 1860): larval identification and genetic relationships with other species of Anisakis Dujardin, 1845 (Nematoda: Anisakidae). Syst Parasitol. 2002;51:159-70 pubmed
    Genetic variation at 21 gene-enzyme systems was studied in a sample of an adult population of Anisakis typica (Diesing, 1860) recovered in the dolphin Sotalia fluviatilis from the Atlantic coast of Brazil...
  91. Du C, Zhang L, Shi M, Ming Z, Hu M, Gasser R. Elucidating the identity of Anisakis larvae from a broad range of marine fishes from the Yellow Sea, China, using a combined electrophoretic-sequencing approach. Electrophoresis. 2010;31:654-8 pubmed publisher
    Larval nematodes were collected from marine fishes from the Yellow Sea, China. Specimens (n=1731) of Anisakis type I from 311 fishes (representing 40 species) were each identified based on morphological characters...
  92. Gamboa P, Asturias J, Martinez R, Antepara I, Jauregui I, Urrutia I, et al. Diagnostic utility of components in allergy to Anisakis simplex. J Investig Allergol Clin Immunol. 2012;22:13-9 pubmed
    In our region, Anisakis allergy is responsible for 8% of acute urticarial reactions, 25% of which progress to anaphylactic shock...