trichuris

Summary

Summary: A genus of nematode worms comprising the whipworms.

Top Publications

  1. Summers R, Elliott D, Urban J, Thompson R, Weinstock J. Trichuris suis therapy in Crohn's disease. Gut. 2005;54:87-90 pubmed
    ..Helminths diminish immune responsiveness in naturally colonised humans and reduce inflammation in experimental colitis. Thus exposure to helminths may help prevent or even ameliorate Crohn's disease...
  2. Knopp S, Mgeni A, Khamis I, Steinmann P, Stothard J, Rollinson D, et al. Diagnosis of soil-transmitted helminths in the era of preventive chemotherapy: effect of multiple stool sampling and use of different diagnostic techniques. PLoS Negl Trop Dis. 2008;2:e331 pubmed publisher
    ..In this study, we focused on schoolchildren on Unguja Island, Zanzibar, an area where anthelminthic drugs have been repeatedly administered over the past decade...
  3. Diawara A, Drake L, Suswillo R, Kihara J, Bundy D, Scott M, et al. Assays to detect beta-tubulin codon 200 polymorphism in Trichuris trichiura and Ascaris lumbricoides. PLoS Negl Trop Dis. 2009;3:e397 pubmed publisher
    The soil-transmitted helminths (STH) Ascaris lumbricoides and Trichuris trichiura are gastrointestinal parasites causing many disabilities to humans, particularly children...
  4. Knopp S, Mohammed K, Stothard J, Khamis I, Rollinson D, Marti H, et al. Patterns and risk factors of helminthiasis and anemia in a rural and a peri-urban community in Zanzibar, in the context of helminth control programs. PLoS Negl Trop Dis. 2010;4:e681 pubmed publisher
    ..The purpose of this study was to determine patterns and risk factors of helminth infections and anemia in a rural and a peri-urban community of Zanzibar, Tanzania, in the context of national helminth control programs...
  5. Geiger S, Massara C, Bethony J, Soboslay P, Carvalho O, Correa Oliveira R. Cellular responses and cytokine profiles in Ascaris lumbricoides and Trichuris trichiura infected patients. Parasite Immunol. 2002;24:499-509 pubmed
    The impact of intestinal helminth infection, i.e. Ascaris lumbricoides and Trichuris trichiura, on cellular responsiveness and cytokine production was investigated in young adults...
  6. Bradley J, Jackson J. Immunity, immunoregulation and the ecology of trichuriasis and ascariasis. Parasite Immunol. 2004;26:429-41 pubmed
    Immune responses to human roundworm (Ascaris lumbricoides) and whipworm (Trichuris trichiura) and their role in controlling worm populations are reviewed. Recent immunoepidemiological data implicate T(H)2-mediated responses in limiting A...
  7. Svensson M, Bell L, Little M, deSchoolmeester M, Locksley R, Else K. Accumulation of eosinophils in intestine-draining mesenteric lymph nodes occurs after Trichuris muris infection. Parasite Immunol. 2011;33:1-11 pubmed publisher
    ..Resistance of mice to infection with the gastrointestinal nematode Trichuris muris depends critically on mounting of a Th2 response and represents a useful model system to investigate Th2 ..
  8. Tu L, Fang T, Artis D, Shestova O, Pross S, Maillard I, et al. Notch signaling is an important regulator of type 2 immunity. J Exp Med. 2005;202:1037-42 pubmed
    ..signaling in CD4+ T cells fail to develop a protective Th2 cell response against the gastrointestinal helminth Trichuris muris. In contrast, they exhibit effective Th1 cell responses and are able to control Leishmania major infection...
  9. Bowcutt R, Bell L, Little M, Wilson J, Booth C, Murray P, et al. Arginase-1-expressing macrophages are dispensable for resistance to infection with the gastrointestinal helminth Trichuris muris. Parasite Immunol. 2011;33:411-20 pubmed publisher
    ..b>Trichuris muris is a worm that resides in the large intestine with resistance being characterized by a Th2 T-cell response,..

More Information

Publications160 found, 100 shown here

  1. Benzel F, Erdur H, Kohler S, Frentsch M, Thiel A, Harms L, et al. Immune monitoring of Trichuris suis egg therapy in multiple sclerosis patients. J Helminthol. 2012;86:339-47 pubmed publisher
    Initial clinical trials using Trichuris suis eggs (TSO) in autoimmune diseases such as inflammatory bowel disease, revealed a striking suppressive effect on the autoimmune response...
  2. Jackson J, Turner J, Kamal M, Wright V, Bickle Q, Else K, et al. Gastrointestinal nematode infection is associated with variation in innate immune responsiveness. Microbes Infect. 2006;8:487-92 pubmed
    ..These results are consistent with the possibility that GI nematodes modulate innate responses and may indicate a potential mechanism for interactions between GI nematodiasis and important bystander pathogens...
  3. Zaph C, Rook K, Goldschmidt M, Mohrs M, Scott P, Artis D. Persistence and function of central and effector memory CD4+ T cells following infection with a gastrointestinal helminth. J Immunol. 2006;177:511-8 pubmed
    ..In this study, we show that following sterile cure of a primary infection with the gastrointestinal parasite Trichuris muris, memory CD4+ T cells persist in the draining mesenteric lymph node and protect mice against reinfection...
  4. Rodrigues L, Newcombe P, Cunha S, Alcantara Neves N, Genser B, Cruz A, et al. Early infection with Trichuris trichiura and allergen skin test reactivity in later childhood. Clin Exp Allergy. 2008;38:1769-77 pubmed publisher
    ..Intestinal helminth parasites are prevalent in childhood in developing countries and are associated with a lower prevalence of allergen skin test reactivity and asthma...
  5. Bell L, Else K. Regulation of colonic epithelial cell turnover by IDO contributes to the innate susceptibility of SCID mice to Trichuris muris infection. Parasite Immunol. 2011;33:244-9 pubmed publisher
    ..Indo gene expression is upregulated in the gut during chronic infection with the mouse whipworm Trichuris muris. We demonstrate an increase in the rate of colonic epithelial cell turnover after inhibition of IDO in T...
  6. Lavrov D, Brown W. Trichinella spiralis mtDNA: a nematode mitochondrial genome that encodes a putative ATP8 and normally structured tRNAS and has a gene arrangement relatable to those of coelomate metazoans. Genetics. 2001;157:621-37 pubmed
    ..The sequence also contains a large repeat region that is polymorphic in size at the population and/or individual level...
  7. Klaver E, Kuijk L, Laan L, Kringel H, van Vliet S, Bouma G, et al. Trichuris suis-induced modulation of human dendritic cell function is glycan-mediated. Int J Parasitol. 2013;43:191-200 pubmed publisher
    ..dendritic cells (DCs) show remarkable phenotypic changes upon direct contact with soluble products (SPs) of Trichuris suis, a pig whipworm that is experimentally used in therapies to ameliorate inflammation in patients with Crohn'..
  8. Mekonnen Z, Levecke B, Boulet G, Bogers J, Vercruysse J. Efficacy of different albendazole and mebendazole regimens against heavy-intensity Trichuris trichiura infections in school children, Jimma Town, Ethiopia. Pathog Glob Health. 2013;107:207-9 pubmed publisher
    ..These observations highlight that assessment of the anthelmintic efficacy of existing or new compounds against Trichuris trichiura should be assessed under varying levels of infection intensity.
  9. Cliffe L, Grencis R. The Trichuris muris system: a paradigm of resistance and susceptibility to intestinal nematode infection. Adv Parasitol. 2004;57:255-307 pubmed
    ..b>Trichuris muris, a natural intestinal parasite of mice has been extensively utilised as a laboratory model for the study ..
  10. Hughes R, Sharp D, Hughes M, Akau ola S, Heinsbroek P, Velayudhan R, et al. Environmental influences on helminthiasis and nutritional status among Pacific schoolchildren. Int J Environ Health Res. 2004;14:163-77 pubmed
    This paper describes a study undertaken to: (1) determine the prevalence of Ascaris lumbricoides, Trichuris trichiura and hookworm infections and nutritional status among Pacific Island school children; (2) identify factors influencing ..
  11. Bager P, Arnved J, Rønborg S, Wohlfahrt J, Poulsen L, Westergaard T, et al. Trichuris suis ova therapy for allergic rhinitis: a randomized, double-blind, placebo-controlled clinical trial. J Allergy Clin Immunol. 2010;125:123-30.e1-3 pubmed publisher
    ..Although no clinical evidence exists to support the use of helminth therapy for allergic disease, the helminth Trichuris suis has demonstrated efficacy in treatment of inflammatory bowel disease...
  12. Pham Duc P, Nguyen Viet H, Hattendorf J, Zinsstag J, Phung Dac C, Zurbrügg C, et al. Ascaris lumbricoides and Trichuris trichiura infections associated with wastewater and human excreta use in agriculture in Vietnam. Parasitol Int. 2013;62:172-80 pubmed publisher
    ..Overall 47% of study participants were infected with any helminth (Ascaris lumbricoides 24%, Trichuris trichiura 40% and hookworm 2%). Infections with intestinal protozoa were rare (i.e...
  13. Taylor M, Else K. Human Trichuris-specific antibody responses in vaccinated hu-PBL-SCID mice. Parasite Immunol. 2002;24:1-13 pubmed
    b>Trichuris trichiura is a highly prevalent intestinal helminth of humans with a well-characterized animal model, Trichuris muris in the mouse...
  14. Summers R, Elliott D, Urban J, Thompson R, Weinstock J. Trichuris suis therapy for active ulcerative colitis: a randomized controlled trial. Gastroenterology. 2005;128:825-32 pubmed
    ..In animal models, helminths prevent or improve colitis by the induction of regulatory T cells and modulatory cytokines. This study determined the efficacy and safety of the helminth Trichuris suis in therapy of ulcerative colitis.
  15. deSchoolmeester M, Manku H, Else K. The innate immune responses of colonic epithelial cells to Trichuris muris are similar in mouse strains that develop a type 1 or type 2 adaptive immune response. Infect Immun. 2006;74:6280-6 pubmed
    b>Trichuris muris resides in intimate contact with its host, burrowing within cecal epithelial cells. However, whether the enterocyte itself responds innately to T. muris is unknown...
  16. Dea Ayuela M, Rama Iñiguez S, Bolas Fernandez F. Enhanced susceptibility to Trichuris muris infection of B10Br mice treated with the probiotic Lactobacillus casei. Int Immunopharmacol. 2008;8:28-35 pubmed
    ..The mouse whipworm Trichuris muris, was used in the susceptible B10Br mice. Mice were treated orally with either viable or dead probiotic L...
  17. Callejon R, Halajian A, de Rojas M, Marrugal A, Guevara D, Cutillas C. 16S partial gene mitochondrial DNA and internal transcribed spacers ribosomal DNA as differential markers of Trichuris discolor populations. Vet Parasitol. 2012;186:350-63 pubmed publisher
    Comparative morphological, biometrical and molecular studies of Trichuris discolor isolated from Bos taurus from Spain and Iran was carried out. Furthermore, Trichuris ovis isolated from B...
  18. Nissen S, Al Jubury A, Hansen T, Olsen A, Christensen H, Thamsborg S, et al. Genetic analysis of Trichuris suis and Trichuris trichiura recovered from humans and pigs in a sympatric setting in Uganda. Vet Parasitol. 2012;188:68-77 pubmed publisher
    The whipworms Trichuris trichiura and Trichuris suis in humans and pigs, respectively, are believed to be two different species yet closely related. Morphologically, adult worms, eggs and larvae of the two species are indistinguishable...
  19. Azira N M, Zeehaida M. Severe chronic iron deficiency anaemia secondary to Trichuris dysentery syndrome - a case report. Trop Biomed. 2012;29:626-31 pubmed
    b>Trichuris dysentery syndrome is caused by Trichuris trichiura which contributes to one of the most common helminthic infections in the world...
  20. Pedersen S, Saeed I, Friis H, Michaelsen K. Effect of iron deficiency on Trichuris suis and Ascaris suum infections in pigs. Parasitology. 2001;122:589-98 pubmed
    ..on a 2 x 2 study where thirty-one 10-week-old pigs fed a low or a normal iron diet were infected with both Trichuris suis (4500 eggs) and Ascaris suum (1200 eggs)...
  21. Cutillas C, Oliveros R, de Rojas M, Guevara D. Determination of Trichuris muris from murid hosts and T. arvicolae (Nematoda) from arvicolid rodents by amplification and sequentiation of the ITS1-5.8S-ITS2 segment of the ribosomal DNA. Parasitol Res. 2002;88:574-82 pubmed
    b>Trichuris muris has been isolated from murid hosts ( Apodemus sylvaticus and Mus musculus) and Trichuris arvicolae from arvicolid rodents in Barcelona, Spain. Genomic DNA was isolated and the ITS1-5...
  22. D Elia R, deSchoolmeester M, Zeef L, Wright S, Pemberton A, Else K. Expulsion of Trichuris muris is associated with increased expression of angiogenin 4 in the gut and increased acidity of mucins within the goblet cell. BMC Genomics. 2009;10:492 pubmed publisher
    b>Trichuris muris in the mouse is an invaluable model for infection of man with the gastrointestinal nematode Trichuris trichiura. Three T. muris isolates have been studied, the Edinburgh (E), the Japan (J) and the Sobreda (S) isolates...
  23. Cutillas C, Oliveros R, de Rojas M, Guevara D. Determination of Trichuris skrjabini by sequencing of the ITS1-5.8S-ITS2 segment of the ribosomal DNA: comparative molecular study of different species of trichurids. J Parasitol. 2004;90:648-52 pubmed
    Adults of Trichuris skrjahini have been isolated from the cecum of caprine hosts (Capra hircus), Trichuris ovis and Trichuris globulosa from Ovis aries (sheep) and C...
  24. Summers R, Elliott D, Weinstock J. Why Trichuris suis should prove safe for use in inflammatory bowel diseases. Inflamm Bowel Dis. 2005;11:783-4 pubmed
  25. Schimmel A, Altreuther G, Schroeder I, Charles S, Cruthers L, Kok D, et al. Efficacy of emodepside plus praziquantel tablets (Profender tablets for dogs) against mature and immature adult Trichuris vulpis infections in dogs. Parasitol Res. 2009;105 Suppl 1:S17-22 pubmed publisher
    ..of emodepside plus praziquantel (Profender tablets for dogs) against mature and immature adult whipworms (Trichuris vulpis) at the proposed minimum dose of 1 mg emodepside and 5 mg praziquantel per kg body weight in dogs...
  26. Shin J, Gardiner G, Deitel W, Kandel G. Does whipworm increase the pathogenicity of Campylobacter jejuni? A clinical correlate of an experimental observation. Can J Gastroenterol. 2004;18:175-7 pubmed
    ..C jejuni colitis leading to toxic megacolon and acute renal failure, associated with concomitant whipworm (Trichuris suis) ova in the feces, is reported...
  27. Kringel H, Roepstorff A. Trichuris suis population dynamics following a primary experimental infection. Vet Parasitol. 2006;139:132-9 pubmed
    b>Trichuris suis population kinetics was studied by experimentally infecting 40 pigs with 5000 T. suis infective eggs. Six pigs were sacrificed every 2 weeks from 1 to 9 weeks post-inoculation (p.i...
  28. Hasnain S, Thornton D, Grencis R. Changes in the mucosal barrier during acute and chronic Trichuris muris infection. Parasite Immunol. 2011;33:45-55 pubmed publisher
    ..analysed the changes of mucosal glycoconjugates during acute and chronic infection by utilising the Trichuris muris (T. muris) model...
  29. Vercruysse J, Behnke J, Albonico M, Ame S, Angebault C, Bethony J, et al. Assessment of the anthelmintic efficacy of albendazole in school children in seven countries where soil-transmitted helminths are endemic. PLoS Negl Trop Dis. 2011;5:e948 pubmed publisher
    The three major soil-transmitted helminths (STH) Ascaris lumbricoides, Trichuris trichiura and Necator americanus/Ancylostoma duodenale are among the most widespread parasites worldwide...
  30. Cliffe L, Potten C, Booth C, Grencis R. An increase in epithelial cell apoptosis is associated with chronic intestinal nematode infection. Infect Immun. 2007;75:1556-64 pubmed
    ..proliferation and the subsequent generation of crypt hyperplasia are hallmarks of chronic infection with Trichuris muris, a large intestinal dwelling nematode...
  31. Klementowicz J, Travis M, Grencis R. Trichuris muris: a model of gastrointestinal parasite infection. Semin Immunopathol. 2012;34:815-28 pubmed publisher
    Infection with soil-transmitted gastrointestinal parasites, such as Trichuris trichiura, affects more than a billion people worldwide, causing significant morbidity and health problems especially in poverty-stricken developing countries...
  32. Midzi N, Mtapuri Zinyowera S, Mapingure M, Sangweme D, Chirehwa M, Brouwer K, et al. Consequences of polyparasitism on anaemia among primary school children in Zimbabwe. Acta Trop. 2010;115:103-11 pubmed publisher
    ..The prevalence of S. haematobium, S. mansoni, P. falciparum, hookworm, Trichuris trichiura and Ascaris lumbricoides were 52.3%, 22.7%, 27.9%, 23.7%, 2.3% and 2.1%, respectively...
  33. Hasnain S, Evans C, Roy M, Gallagher A, Kindrachuk K, Barron L, et al. Muc5ac: a critical component mediating the rejection of enteric nematodes. J Exp Med. 2011;208:893-900 pubmed publisher
    ..of Muc5ac, a mucin not normally expressed in the intestinal tract, is induced in the cecum of mice resistant to Trichuris muris infection...
  34. Halpenny C, Paller C, Koski K, Valdés V, Scott M. Regional, household and individual factors that influence soil transmitted helminth reinfection dynamics in preschool children from rural indigenous Panamá. PLoS Negl Trop Dis. 2013;7:e2070 pubmed publisher
    ..The present study examined reinfection dynamics and spatial clustering of Ascaris lumbricoides, Trichuris trichiura and hookworm in an extremely impoverished indigenous setting in rural Panamá over a 16 month period ..
  35. deSchoolmeester M, Martinez Pomares L, Gordon S, Else K. The mannose receptor binds Trichuris muris excretory/secretory proteins but is not essential for protective immunity. Immunology. 2009;126:246-55 pubmed publisher
    b>Trichuris muris is a natural mouse model of the human gastrointestinal nematode parasite Trichuris trichiura and it is well established that a T helper type 2-dominated immune response is required for worm expulsion...
  36. Levecke B, De Wilde N, Vandenhoute E, Vercruysse J. Field validity and feasibility of four techniques for the detection of Trichuris in simians: a model for monitoring drug efficacy in public health?. PLoS Negl Trop Dis. 2009;3:e366 pubmed publisher
    Soil-transmitted helminths, such as Trichuris trichiura, are of major concern in public health. Current efforts to control these helminth infections involve periodic mass treatment in endemic areas...
  37. Cutillas C, Callejon R, de Rojas M, Tewes B, Ubeda J, Ariza C, et al. Trichuris suis and Trichuris trichiura are different nematode species. Acta Trop. 2009;111:299-307 pubmed publisher
    ..paper, a morphological and biometrical study by optical microscopy and scanning electronic microscopy (SEM) of Trichuris suis isolated from different hosts (Sus scrofa domestica and Sus scrofa scrofa) and Trichuris trichiura isolated ..
  38. Tilney L, Connelly P, Guild G, Vranich K, Artis D. Adaptation of a nematode parasite to living within the mammalian epithelium. J Exp Zool A Comp Exp Biol. 2005;303:927-45 pubmed
    b>Trichuris muris is a large metazoan pathogen that has been proposed to live intracellularly within living host intestinal epithelial cells...
  39. Kobayashi A, Hara T, Kajima J. Historical aspects for the control of soil-transmitted helminthiases. Parasitol Int. 2006;55 Suppl:S289-91 pubmed
    ..The parasitologists group conducted studies in all aspects to seek effective STH control measures for respective countries and obtained many successful results...
  40. Jackson J, Turner J, Rentoul L, Faulkner H, Behnke J, Hoyle M, et al. T helper cell type 2 responsiveness predicts future susceptibility to gastrointestinal nematodes in humans. J Infect Dis. 2004;190:1804-11 pubmed
    ..Ascaris lumbricoides and Trichuris trichiura abundance was assessed immediately before and 8-9 months after deworming in a Cameroonian population (..
  41. Mullaly S, Burrows K, Antignano F, Zaph C. Assessing the role of CD103 in immunity to an intestinal helminth parasite. PLoS ONE. 2011;6:e19580 pubmed publisher
    ..However, the role of CD103 during intestinal helminth infection has not been tested...
  42. Cooper P, Chico M, Losonsky G, Sandoval C, Espinel I, Sridhara R, et al. Albendazole treatment of children with ascariasis enhances the vibriocidal antibody response to the live attenuated oral cholera vaccine CVD 103-HgR. J Infect Dis. 2000;182:1199-206 pubmed
    ..lumbricoides infections impair the immune response to oral cholera vaccine, particularly in subjects of non-O blood groups. ..
  43. Owyang A, Zaph C, Wilson E, Guild K, McClanahan T, Miller H, et al. Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract. J Exp Med. 2006;203:843-9 pubmed
    ..of genetically susceptible mice with exogenous IL-25 promoted type 2 cytokine responses and immunity to Trichuris. IL-25 was constitutively expressed by CD4+ and CD8+ T cells in the gut of mouse strains that are resistant to ..
  44. Fleming J, Cook T. Multiple sclerosis and the hygiene hypothesis. Neurology. 2006;67:2085-6 pubmed
  45. Siniscalco D, Antonucci N. Possible use of Trichuris suis ova in autism spectrum disorders therapy. Med Hypotheses. 2013;81:1-4 pubmed publisher
    ..e. inflammatory bowel disease, asthma, multiple sclerosis and autoimmune diabetes). Trichuris suis ova (TSO) show strong immunomodulatory properties...
  46. Koyama K. Dendritic cell expansion occurs in mesenteric lymph nodes of B10.BR mice infected with the murine nematode parasite Trichuris muris. Parasitol Res. 2005;97:186-90 pubmed
    ..Th2 effectors are required for protection against the murine nematode parasite Trichuris muris, and thus CD11c+ B220- DCs may be involved in the induction of Th2 cells in T. muris infection...
  47. Diniz Santos D, Jambeiro J, Mascarenhas R, Silva L. Massive Trichuris trichiura infection as a cause of chronic bloody diarrhea in a child. J Trop Pediatr. 2006;52:66-8 pubmed
    ..A few patients infected by Trichuris trichiura may present a chronic dysentery-like syndrome in the context of a massive infestation of the colon ..
  48. Dixon H, Johnston C, Else K. Antigen selection for future anti-Trichuris vaccines: a comparison of cytokine and antibody responses to larval and adult antigen in a primary infection. Parasite Immunol. 2008;30:454-61 pubmed publisher
    Trichuriasis, caused by the whipworm Trichuris trichiura, is endemic in tropical and subtropical areas, affecting approximately 1 billion people...
  49. Tarafder M, Carabin H, Joseph L, Balolong E, Olveda R, McGarvey S. Estimating the sensitivity and specificity of Kato-Katz stool examination technique for detection of hookworms, Ascaris lumbricoides and Trichuris trichiura infections in humans in the absence of a 'gold standard'. Int J Parasitol. 2010;40:399-404 pubmed publisher
    ..and specificity of the Kato-Katz technique to detect infection with Ascaris lumbricoides, hookworm and Trichuris trichiura using a Bayesian approach in the absence of a 'gold standard'...
  50. Larocque R, Casapia M, Gotuzzo E, Gyorkos T. Relationship between intensity of soil-transmitted helminth infections and anemia during pregnancy. Am J Trop Med Hyg. 2005;73:783-9 pubmed
    ..31% of 1,042 women had anemia (hemoglobin < 11 g/dL), 47.22% were infected with hookworm and 82.25% with Trichuris. Prevalences of infections were not associated with anemia...
  51. de Cássia Ribeiro Silva R, Barreto M, Assis A, de Santana M, Parraga I, Reis M, et al. The relative influence of polyparasitism, environment, and host factors on schistosome infection. Am J Trop Med Hyg. 2007;77:672-5 pubmed
    ..Thus, polyparasitism itself, as well as intrinsic host factors, appears to produce greater susceptibility to additional helminth infections...
  52. Alcantara Neves N, Badaró S, dos Santos M, Pontes de Carvalho L, Barreto M. The presence of serum anti-Ascaris lumbricoides IgE antibodies and of Trichuris trichiura infection are risk factors for wheezing and/or atopy in preschool-aged Brazilian children. Respir Res. 2010;11:114 pubmed publisher
    ..In developing countries, intestinal helminthic infections have also been associated with allergy or atopy-related disorders...
  53. Stephenson L, Holland C, Cooper E. The public health significance of Trichuris trichiura. Parasitology. 2000;121 Suppl:S73-95 pubmed
    ..The Trichuris dysentery syndrome (TDS) associated with heavy T...
  54. Blackwell N, Else K. A comparison of local and peripheral parasite-specific antibody production in different strains of mice infected with Trichuris muris. Parasite Immunol. 2002;24:203-11 pubmed
    The serum parasite-specific antibody responses of different mouse strains infected with Trichuris muris reflect the nature of the T-helper response mounted by the host, in that resistant Th2-responding strains, such as BALB/K, produce ..
  55. Keiser J, Tritten L, Adelfio R, Vargas M. Effect of combinations of marketed human anthelmintic drugs against Trichuris muris in vitro and in vivo. Parasit Vectors. 2012;5:292 pubmed publisher
    ..the main standard anthelmintics, albendazole, mebendazole, levamisole, pyrantel pamoate and ivermectin in the Trichuris muris model...
  56. Liu G, Gasser R, Nejsum P, Wang Y, Chen Q, Song H, et al. Mitochondrial and nuclear ribosomal DNA evidence supports the existence of a new Trichuris species in the endangered françois' leaf-monkey. PLoS ONE. 2013;8:e66249 pubmed publisher
    The whipworm of humans, Trichuris trichiura, is responsible for a neglected tropical disease (NTD) of major importance in tropical and subtropical countries of the world...
  57. Hasnain S, Wang H, Ghia J, Haq N, Deng Y, Velcich A, et al. Mucin gene deficiency in mice impairs host resistance to an enteric parasitic infection. Gastroenterology. 2010;138:1763-71 pubmed publisher
    ..Nevertheless, the precise role of mucins in host defense in nematode infection is not known. We investigated the role of the mucin (Muc2) in worm expulsion and host immunity in a model of nematode infection...
  58. Márquez Navarro A, García Bracamontes G, Alvarez Fernández B, Ávila Caballero L, Santos Aranda I, Díaz Chiguer D, et al. Trichuris vulpis (Froelich, 1789) infection in a child: a case report. Korean J Parasitol. 2012;50:69-71 pubmed publisher
    We present a human infection with the canine whipworm, Trichuris vulpis, in a child suffering from rhinitis with a diagnosis of rhinitis. T. vulpis eggs resemble those of T...
  59. Amare B, Ali J, Moges B, Yismaw G, Belyhun Y, Gebretsadik S, et al. Nutritional status, intestinal parasite infection and allergy among school children in northwest Ethiopia. BMC Pediatr. 2013;13:7 pubmed publisher
    ..The present study was therefore designed to evaluate the relationship between nutritional status, parasite infection and prevalence of allergy among school children...
  60. Cutillas C, de Rojas M, Ariza C, Ubeda J, Guevara D. Molecular identification of Trichuris vulpis and Trichuris suis isolated from different hosts. Parasitol Res. 2007;100:383-9 pubmed
    b>Trichuris suis was isolated from the cecum of two different hosts (Sus scrofa domestica -- swine and Sus scrofa scrofa -- wild boar) and Trichuris vulpis from dogs in Sevilla, Spain...
  61. Williams Blangero S, Vandeberg J, Subedi J, Jha B, Dyer T, Blangero J. Two quantitative trait loci influence whipworm (Trichuris trichiura) infection in a Nepalese population. J Infect Dis. 2008;197:1198-203 pubmed publisher
    Whipworm (Trichuris trichiura) infection is a soil-transmitted helminth infection that affects >1 billion people...
  62. Blackwell N, Else K. B cells and antibodies are required for resistance to the parasitic gastrointestinal nematode Trichuris muris. Infect Immun. 2001;69:3860-8 pubmed
    ..knockout mice have shown that B cells and antibodies are not essential components of the expulsion mechanism in Trichuris muris infections...
  63. Wilson E, Zaph C, Mohrs M, Welcher A, Siu J, Artis D, et al. B7RP-1-ICOS interactions are required for optimal infection-induced expansion of CD4+ Th1 and Th2 responses. J Immunol. 2006;177:2365-72 pubmed
    ..the role of ICOS in the development of infection-induced polarized Th cells, ICOS(-/-) mice were infected with Trichuris muris or Toxoplasma gondii. Wild-type mice challenged with T...
  64. Turner J, Faulkner H, Kamgno J, Else K, Boussinesq M, Bradley J. A comparison of cellular and humoral immune responses to trichuroid derived antigens in human trichuriasis. Parasite Immunol. 2002;24:83-93 pubmed
    Individuals, residing in a region highly endemic for Trichuris trichiura, were examined for cytokine and proliferative responses to T. trichiura worm homogenate (TtAg), T...
  65. Petry G, Altreuther G, Wolken S, Swart P, Kok D. Efficacy of emodepside plus toltrazuril oral suspension for dogs (Procox®, Bayer) against Trichuris vulpis in naturally infected dogs. Parasitol Res. 2013;112 Suppl 1:133-8 pubmed publisher
    The efficacy of emodepside plus toltrazuril oral suspension for dogs (Procox®, Bayer) against Trichuris vulpis was evaluated in a controlled, blinded and randomised laboratory study. Twenty naturally infected dogs were included...
  66. Zaph C, Troy A, Taylor B, Berman Booty L, Guild K, Du Y, et al. Epithelial-cell-intrinsic IKK-beta expression regulates intestinal immune homeostasis. Nature. 2007;446:552-6 pubmed
    ..cytokine thymic stromal lymphopoietin in the intestine and, after infection with the gut-dwelling parasite Trichuris, fail to develop a pathogen-specific CD4+ T helper type 2 (T(H)2) response and are unable to eradicate infection...
  67. Yajima A, Jouquet P, Do T, Dang T, Tran C, Orange D, et al. High latrine coverage is not reducing the prevalence of soil-transmitted helminthiasis in Hoa Binh province, Vietnam. Trans R Soc Trop Med Hyg. 2009;103:237-41 pubmed publisher
    ..The prevalence of Ascaris lumbricoides, Trichuris trichiura and hookworm infection was 13.5%, 45.2% and 58.1%, respectively...
  68. Cruickshank S, deSchoolmeester M, Svensson M, Howell G, Bazakou A, Logunova L, et al. Rapid dendritic cell mobilization to the large intestinal epithelium is associated with resistance to Trichuris muris infection. J Immunol. 2009;182:3055-62 pubmed publisher
    ..We used the well-established model of Trichuris muris infection to investigate the innate response of colonic DCs in mice that are inherently resistant or ..
  69. Pullan R, Brooker S. The global limits and population at risk of soil-transmitted helminth infections in 2010. Parasit Vectors. 2012;5:81 pubmed publisher
    ..economic development on STH transmission, and estimate numbers at-risk of infection with Ascaris lumbricoides, Trichuris trichiura and hookworm in 2010...
  70. Hsu S, Tseng P, Chen P. Trichuris suis therapy for ulcerative colitis: nonresponsive patients may need anti-helminth therapy. Gastroenterology. 2005;129:768-9; author reply 769 pubmed
  71. Bager P, Kapel C, Roepstorff A, Thamsborg S, Arnved J, Rønborg S, et al. Symptoms after ingestion of pig whipworm Trichuris suis eggs in a randomized placebo-controlled double-blind clinical trial. PLoS ONE. 2011;6:e22346 pubmed publisher
    Symptoms after human infection with the helminth Trichuris suis have not previously been described. Exposure to helminths has been suggested as immune therapy against allergy and autoimmune diseases...
  72. Bourke C, Mutapi F, Nausch N, Photiou D, Poulsen L, Kristensen B, et al. Trichuris suis ova therapy for allergic rhinitis does not affect allergen-specific cytokine responses despite a parasite-specific cytokine response. Clin Exp Allergy. 2012;42:1582-95 pubmed publisher
    ..However, in humans, the effects of controlled helminth infection on cytokine responses during allergy have not been studied...
  73. Ranque S, Chippaux J, Garcia A, Boussinesq M. Follow-up of Ascaris lumbricoides and Trichuris trichiura infections in children living in a community treated with ivermectin at 3-monthly intervals. Ann Trop Med Parasitol. 2001;95:389-93 pubmed
    ..1994) to the whole eligible population of a village in South Cameroon where both Ascaris lumbricoides and Trichuris trichiura were hyper-endemic. A parasitological stool examination was performed before each treatment...
  74. Parthasarathy G, Mansfield L. Trichuris suis excretory secretory products (ESP) elicit interleukin-6 (IL-6) and IL-10 secretion from intestinal epithelial cells (IPEC-1). Vet Parasitol. 2005;131:317-24 pubmed
    ..In fact, the whipworm parasite of swine, Trichuris suis, has been used in beginning clinical trials as an antidote to inflammatory bowel disease...
  75. Hayes K, Bancroft A, Grencis R. The role of TNF-alpha in Trichuris muris infection I: influence of TNF-alpha receptor usage, gender and IL-13. Parasite Immunol. 2007;29:575-82 pubmed
    Th1 and Th2 responses to the gut-dwelling nematode Trichuris muris have been well established in mouse models of infection, with Th2 responses clearly playing an important role in resistance...
  76. Gyorkos T, Maheu Giroux M, Casapia M, Joseph S, Creed Kanashiro H. Stunting and helminth infection in early preschool-age children in a resource-poor community in the Amazon lowlands of Peru. Trans R Soc Trop Med Hyg. 2011;105:204-8 pubmed publisher
    ..The Kato-Katz method was used to determine the prevalence and intensity of Ascaris, Trichuris, and hookworm infections. Of 370 participating children, 349 had parasitological results...
  77. Hasnain S, McGuckin M, Grencis R, Thornton D. Serine protease(s) secreted by the nematode Trichuris muris degrade the mucus barrier. PLoS Negl Trop Dis. 2012;6:e1856 pubmed publisher
    ..We used the well-established Trichuris muris nematode model to investigate the effect on mucins of the complex mixture of immunogenic proteins secreted ..
  78. Bennett A, Anderson T, Barker G, Michael E, Bundy D. Sequence variation in the Trichuris trichiura beta-tubulin locus: implications for the development of benzimidazole resistance. Int J Parasitol. 2002;32:1519-28 pubmed
    ..Here we investigate sequence variation in a 1079 bp segment of the beta-tubulin locus in the human whipworm Trichuris trichiura from 72 individual nematodes from seven countries...
  79. Mansfield L, Gauthier D. Lymphoglandular complexes are important colonic sites for immunoglobulin A induction against Campylobacter jejuni in a swine disease model. Comp Med. 2004;54:514-23 pubmed
    ..In an experimental model of human infection, germfree pigs were given C. jejuni, the whipworm Trichuris suis, dual infections with C. jejuni and T. suis, or no infection...
  80. Kornaś S, Nowosad B, Skalska M. [The evaluation of Trichuris vulpis infection of stray dogs in Kraków area]. Wiad Parazytol. 2002;48:401-6 pubmed
    The evaluation of Trichuris vulpis infection of unwanted dogs in Kraków area. The aim of this work was the estimation of the infection with Trichuris vulpis of dogs in Cracow's Shelter for Stray Animals...
  81. Knopp S, Speich B, Hattendorf J, Rinaldi L, Mohammed K, Khamis I, et al. Diagnostic accuracy of Kato-Katz and FLOTAC for assessing anthelmintic drug efficacy. PLoS Negl Trop Dis. 2011;5:e1036 pubmed publisher
    ..We compared the diagnostic accuracy of the Kato-Katz and FLOTAC techniques in the frame of a drug efficacy trial...
  82. Cooper P, Chico M, Sandoval C, Espinel I, Guevara A, Kennedy M, et al. Human infection with Ascaris lumbricoides is associated with a polarized cytokine response. J Infect Dis. 2000;182:1207-13 pubmed
    ..05) and L3/L4 stage (P<.001) antigens. Analysis of these data indicates that A. lumbricoides infections in endemic regions are associated with a highly polarized type 2 cytokine response. ..
  83. Summers R, Elliott D, Weinstock J. Is there a role for helminths in the therapy of inflammatory bowel disease?. Nat Clin Pract Gastroenterol Hepatol. 2005;2:62-3 pubmed
  84. Casapia M, Joseph S, Núñez C, Rahme E, Gyorkos T. Parasite and maternal risk factors for malnutrition in preschool-age children in Belen, Peru using the new WHO Child Growth Standards. Br J Nutr. 2007;98:1259-66 pubmed
    ..Risk factors for wasting were: (1) moderate-high intensity Trichuris infection (OR 2.50; 95 % CI 1.06, 5.93); (2) hookworm infection (OR 6.67; 95 % CI 1.08, 41...
  85. Liu G, Gasser R, Su A, Nejsum P, Peng L, Lin R, et al. Clear genetic distinctiveness between human- and pig-derived Trichuris based on analyses of mitochondrial datasets. PLoS Negl Trop Dis. 2012;6:e1539 pubmed publisher
    The whipworm, Trichuris trichiura, causes trichuriasis in ?600 million people worldwide, mainly in developing countries. Whipworms also infect other animal hosts, including pigs (T. suis), dogs (T...
  86. D Elia R, Behnke J, Bradley J, Else K. Regulatory T cells: a role in the control of helminth-driven intestinal pathology and worm survival. J Immunol. 2009;182:2340-8 pubmed publisher
    ..We have explored both these aspects using the murine model of whipworm infection, Trichuris muris. Of the three laboratory isolates of T...
  87. Quihui Cota L, Morales Figueroa G, Esparza Romero J, Valencia M, Astiazaran Garcia H, Méndez R, et al. Trichuriasis and low-iron status in schoolchildren from Northwest Mexico. Eur J Clin Nutr. 2010;64:1108-15 pubmed publisher
    ..Adjusted models were tested for linear regression assumptions using residual plots. The mean age of the Trichuris-free and Trichuris-infected groups was 7.7±1.3 and 7.7±1.5 years respectively (P=0.92)...
  88. Cantacessi C, Young N, Nejsum P, Jex A, Campbell B, Hall R, et al. The transcriptome of Trichuris suis--first molecular insights into a parasite with curative properties for key immune diseases of humans. PLoS ONE. 2011;6:e23590 pubmed publisher
    Iatrogenic infection of humans with Trichuris suis (a parasitic nematode of swine) is being evaluated or promoted as a biological, curative treatment of immune diseases, such as inflammatory bowel disease (IBD) and ulcerative colitis, in ..
  89. Li R, Wu S, Li W, Navarro K, Couch R, Hill D, et al. Alterations in the porcine colon microbiota induced by the gastrointestinal nematode Trichuris suis. Infect Immun. 2012;80:2150-7 pubmed publisher
    ..In this study, we characterized the microbiota in the porcine proximal colon in response to Trichuris suis (whipworm) infection using 16S rRNA gene-based and whole-genome shotgun (WGS) sequencing. A 21-day T...
  90. Artis D. New weapons in the war on worms: identification of putative mechanisms of immune-mediated expulsion of gastrointestinal nematodes. Int J Parasitol. 2006;36:723-33 pubmed
    ..Harnessing these discoveries, coupled with identifying what the targets of these responses are within parasitic nematodes, offers promise in the design of a new generation of anti-parasitic drugs and vaccines...
  91. Zaiss D, Yang L, Shah P, Kobie J, Urban J, Mosmann T. Amphiregulin, a TH2 cytokine enhancing resistance to nematodes. Science. 2006;314:1746 pubmed
    ..directly induce epithelial cell proliferation, and lack of amphiregulin delayed expulsion of the nematode Trichuris muris...
  92. Knopp S, Rinaldi L, Khamis I, Stothard J, Rollinson D, Maurelli M, et al. A single FLOTAC is more sensitive than triplicate Kato-Katz for the diagnosis of low-intensity soil-transmitted helminth infections. Trans R Soc Trop Med Hyg. 2009;103:347-54 pubmed publisher
    ..Considering the pooled results of both methods as diagnostic 'gold' standard, the observed prevalences of Trichuris trichiura, hookworm and Ascaris lumbricoides were 63.4, 35.8 and 22.9%, respectively...