trichinella spiralis

Summary

Summary: A parasite of carnivorous mammals that causes TRICHINELLOSIS. It is especially common in rats and in swine fed uncooked garbage. Human infection is initiated by the consumption of raw or insufficiently cooked pork or other meat containing the encysted larvae.

Top Publications

  1. Suzuki T, Sasaki T, Takagi H, Sato K, Ueda K. The effectors responsible for gastrointestinal nematode parasites, Trichinella spiralis, expulsion in rats. Parasitol Res. 2008;103:1289-95 pubmed publisher
    ..Th2) cells type 2 have a central role in host protective responses to gastrointestinal nematode parasite, Trichinella spiralis infection, but the actual effector mechanisms involved in parasite expulsion are still uncertain...
  2. Gare D, Boyd J, Connolly B. Developmental regulation and secretion of nematode-specific cysteine-glycine domain proteins in Trichinella spiralis. Mol Biochem Parasitol. 2004;134:257-66 pubmed
    The muscle larva of Trichinella spiralis is an intracellular parasite of mammalian skeletal muscle, encapsulating within a portion of the myofiber and resulting in muscle de-differentiation...
  3. Gruden Movsesijan A, Milosavljevic L. The involvement of the macrophage mannose receptor in the innate immune response to infection with parasite Trichinella spiralis. Vet Immunol Immunopathol. 2006;109:57-67 pubmed
    ..Since Trichinella spiralis antigens are rich in oligomannose residues, we investigated whether a mannose-recognizing receptor, such as ..
  4. Robinson M, Connolly B. Proteomic analysis of the excretory-secretory proteins of the Trichinella spiralis L1 larva, a nematode parasite of skeletal muscle. Proteomics. 2005;5:4525-32 pubmed
    b>Trichinella spiralis is an intracellular nematode parasite of mammalian skeletal muscle...
  5. Kang Y, Jo J, Cho M, Yu H, Cha H, Ock M. Trichinella spiralis infection induces ?-actin co-localized with thymosin ?4. Vet Parasitol. 2012;187:480-5 pubmed publisher
    b>Trichinella spiralis (T. spiralis) infection in muscle is characterized by the vascular network for the nurse cell-larva complex. We showed in a previous report that thymosin ?4 was up-regulated during nurse cell formation by T. spiralis...
  6. Martin F, Verdu E, Wang Y, Dumas M, Yap I, Cloarec O, et al. Transgenomic metabolic interactions in a mouse disease model: interactions of Trichinella spiralis infection with dietary Lactobacillus paracasei supplementation. J Proteome Res. 2006;5:2185-93 pubmed
    ..Here, we have used a Trichinella spiralis (T...
  7. Bliss S, Alcaraz A, Appleton J. IL-10 prevents liver necrosis during murine infection with Trichinella spiralis. J Immunol. 2003;171:3142-7 pubmed
    Infection with Trichinella spiralis rarely leads to significant morbidity...
  8. Furze R, Culley F, Selkirk M. Differential roles of the co-stimulatory molecules GITR and CTLA-4 in the immune response to Trichinella spiralis. Microbes Infect. 2006;8:2803-10 pubmed
    ..and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) in murine infection with the nematode parasite Trichinella spiralis. Expression of GITR and CTLA-4 was rapidly upregulated on cells in the mesenteric lymph nodes and spleen, ..
  9. Walsh R, Seth R, Behnke J, Potten C, Mahida Y. Epithelial stem cell-related alterations in Trichinella spiralis-infected small intestine. Cell Prolif. 2009;42:394-403 pubmed publisher
    Infection of mice with the parasite Trichinella spiralis leads to small intestinal inflammation, characterized by changes in mucosal architecture and subpopulations of epithelial cells...

More Information

Publications142 found, 100 shown here

  1. Ilic N, Gruden Movsesijan A, Sofronic Milosavljevic L. Trichinella spiralis: shaping the immune response. Immunol Res. 2012;52:111-9 pubmed publisher
    ..b>Trichinella spiralis (T...
  2. Dzik J. Molecules released by helminth parasites involved in host colonization. Acta Biochim Pol. 2006;53:33-64 pubmed
    ..An intracellular metazoan parasite, Trichinella spiralis, secretes, among others, protein kinases and phosphatases, endonucleases, and DNA-binding proteins, which ..
  3. Suzuki T, Ishih A, Kino H, Muregi F, Takabayashi S, Nishikawa T, et al. Chromosomal mapping of host resistance loci to Trichinella spiralis nematode infection in rats. Immunogenetics. 2006;58:26-30 pubmed
    The differences in host response among strains of rats to intestinal nematode parasite Trichinella spiralis infection could provide a powerful benefit for further elucidation of molecular interactions between the host and the parasite...
  4. Quan F, Matsumoto T, Lee J, Timothy O, Kim T, Joo K, et al. Immunization with Trichinella spiralis Korean isolate larval excretory-secretory antigen induces protection and lymphocyte subset changes in rats. Immunol Invest. 2004;33:15-26 pubmed
    Protection and immune responses were studied in rats immunized with Trichinella spiralis muscle stage larval excretory-secretory antigen (ES Ag) without adjuvant...
  5. Knight P, Brown J, Pemberton A. Innate immune response mechanisms in the intestinal epithelium: potential roles for mast cells and goblet cells in the expulsion of adult Trichinella spiralis. Parasitology. 2008;135:655-70 pubmed publisher
    SUMMARYGastrointestinal infection with the nematode Trichinella spiralis is accompanied by a rapid and reversible expansion of the mucosal mast cell and goblet cell populations in the intestinal epithelium, which is associated with the ..
  6. Dávila López M, Rosenblad M, Samuelsson T. Computational screen for spliceosomal RNA genes aids in defining the phylogenetic distribution of major and minor spliceosomal components. Nucleic Acids Res. 2008;36:3001-10 pubmed publisher
    ..in a number of phylogenetic groups where previously such RNAs were not observed, including the nematode Trichinella spiralis, the slime mold Physarum polycephalum and the fungal lineages Zygomycota and Chytridiomycota...
  7. Leech M, Grencis R. Induction of enhanced immunity to intestinal nematodes using IL-9-producing dendritic cells. J Immunol. 2006;176:2505-11 pubmed
    ..of Ag-pulsed bone marrow-derived dendritic cells (BMDCs) enhanced expulsion of the intestinal nematode, Trichinella spiralis, from the small intestine...
  8. Urbizu L, Confalonieri A, Sánchez Bruni S, Lanusse C, Ignacio Alvarez L. Nematodicidal activity of flubendazole and its reduced metabolite on a murine model of Trichinella spiralis infection. Chemotherapy. 2012;58:295-8 pubmed publisher
    ..The goal of the current work was to assess the efficacy of FLBZ and R-FLBZ against Trichinella spiralis in a mouse model. Both compounds were administered to Balb/c mice infected with T...
  9. Nuñez G, Costantino S, Gentile T, Venturiello S. Immunoparasitological evaluation of Trichinella spiralis infection during human pregnancy: a small case series. Trans R Soc Trop Med Hyg. 2008;102:662-8 pubmed publisher
    The clinical background, vertical transmission of Trichinella spiralis and helminthotoxic activity of sera were evaluated in four pregnant women infected at different gestation times...
  10. Stojcevic D, Zivicnjak T, Marinculic A, Marucci G, Andelko G, Brstilo M, et al. The epidemiological investigation of Trichinella infection in brown rats (Rattus norvegicus) and domestic pigs in Croatia suggests that rats are not a reservoir at the farm level. J Parasitol. 2004;90:666-70 pubmed
    ..infection in pigs has been endemic in the past 10 yr. Trichinella spiralis larvae, identified by a multiplex polymerase chain reaction analyses, were the only species detected in ..
  11. Pettitt J, Muller B, Stansfield I, Connolly B. Spliced leader trans-splicing in the nematode Trichinella spiralis uses highly polymorphic, noncanonical spliced leaders. RNA. 2008;14:760-70 pubmed publisher
    ..Here we report the identification of spliced leader trans-splicing in the basal nematode Trichinella spiralis, and show that this nematode does not possess a canonical SL1, but rather has at least 15 distinct spliced ..
  12. Wang S, Wang Z, Cui J. Protein change of intestinal epithelial cells induced in vitro by Trichinella spiralis infective larvae. Parasitol Res. 2011;108:593-9 pubmed publisher
    The aim of this study was to observe the protein changes of intestinal epithelial cells induced in vitro by Trichinella spiralis infective larvae and their excretory-secretory (ES) or surface antigens and identity the proteins related ..
  13. Mitreva M, Jasmer D, Appleton J, Martin J, Dante M, Wylie T, et al. Gene discovery in the adenophorean nematode Trichinella spiralis: an analysis of transcription from three life cycle stages. Mol Biochem Parasitol. 2004;137:277-91 pubmed
    ..from cDNA libraries for immature L1, mature muscle larva and adult stages of the adenophorean nematode Trichinella spiralis. 10,130 ESTs were grouped into 3454 gene clusters...
  14. Abu El Ezz N. Effect of Nigella sativa and Allium cepa oils on Trichinella spiralis in experimentally infected rats. J Egypt Soc Parasitol. 2005;35:511-23 pubmed
    ..sativa oil. In conclusion, N. sativa and A. cepa oils have anthelmintic effect in the rats infected with T. spiralis infection and increased the production of antibodies generated during life cycle of this parasite. ..
  15. Langelaar M, Aranzamendi C, Franssen F, van der Giessen J, Rutten V, van der Ley P, et al. Suppression of dendritic cell maturation by Trichinella spiralis excretory/secretory products. Parasite Immunol. 2009;31:641-5 pubmed publisher
    ..Here, we focus on the effect of Trichinella spiralis excretory/secretory antigens (TspES) on the innate immune response by studying the effect of TspES on DC ..
  16. Chen M, Ai L, Xu M, Chen S, Zhang Y, Guo J, et al. Identification and characterization of microRNAs in Trichinella spiralis by comparison with Brugia malayi and Caenorhabditis elegans. Parasitol Res. 2011;109:553-8 pubmed publisher
    b>Trichinella spiralis is an important zoonotic nematode causing trichinellosis which is associated with human diseases such as malaise, anorexia, nausea, vomiting, abdominal pain, fever, diarrhea, and constipation...
  17. Aranzamendi C, de Bruin A, Kuiper R, Boog C, van Eden W, Rutten V, et al. Protection against allergic airway inflammation during the chronic and acute phases of Trichinella spiralis infection. Clin Exp Allergy. 2013;43:103-15 pubmed publisher
    ..We have previously shown that excretory-secretory products of Trichinella spiralis muscle larvae have immunomodulatory properties and induce in vitro the expansion of CD4(+) CD25(+) FOXP3(+) ..
  18. Wong C, Mak C, Ko R. Cloning and characterization of the mitochondrial heat-shock protein 60 gene of Trichinella spiralis. Parasitol Res. 2004;93:461-7 pubmed
    The full-length cDNA of mitochondrial heat-shock protein (hsp) 60 of the infective-stage larva of Trichinella spiralis was cloned by degenerative PCR and rapid amplification of cDNA end reactions...
  19. Kołodziej Sobocińska M, Dziemian E, Machnicka Rowińska B. Inhibition of nitric oxide production by aminoguanidine influences the number of Trichinella spiralis parasites in infected "low responders" (C57BL/6) and "high responders" (BALB/c) mice. Parasitol Res. 2006;99:194-6 pubmed
    The influence of nitric oxide (NO) on the development of adults and larvae Trichinella spiralis was examined in two strains of mice: C57BL/6 and BALB/c...
  20. Li Q, Yang J, Yang Y, Gu Y, Liu Z, Huang S, et al. [Effect of different adjuvant formulations on the induced protection of mice immunized with recombinant protein ts87 of Trichinella spiralis]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2007;25:101-5 pubmed
    ..6 formulations of adjuvants on immunoprotection in mice induced by the recombinant Ts87 protein (rTs87) of Trichinella spiralis. ICR mice were vaccinated subcutaneously 3 times in 2-week intervals with rTs87 and different adjuvants CFA ..
  21. Deville S, Pooter A, Aucouturier J, Lainé Prade V, Cote M, Boireau P, et al. Influence of adjuvant formulation on the induced protection of mice immunized with total soluble antigen of Trichinella spiralis. Vet Parasitol. 2005;132:75-80 pubmed
    ..In this study, two adjuvants were selected to prepare vaccines based on total soluble Trichinella spiralis muscle larvae (ML) antigen: Montanide ISA 70 water in oil emulsion and Montanide IMS nanoparticles...
  22. Yang Y, Qin W, Tian G, Jian W. Expression and functional characterization of a Rho-family small GTPase CDC42 from Trichinella spiralis. Parasitol Res. 2010;107:153-62 pubmed publisher
    A full-length cDNA encoding a Rho-family small GTPase gene cdc42 of Trichinella spiralis was expressed in E. coli. The recombinant protein of TsCDC42 was purified and used to raise the polyclonal antibodies...
  23. Gurish M, Bryce P, Tao H, Kisselgof A, Thornton E, Miller H, et al. IgE enhances parasite clearance and regulates mast cell responses in mice infected with Trichinella spiralis. J Immunol. 2004;172:1139-45 pubmed
    b>Trichinella spiralis infection elicits a vigorous IgE response and pronounced intestinal and splenic mastocytosis in mice...
  24. Park J, Park S, Cho M, Park M, Kang S, Kim D, et al. Molecular characterization of 45 kDa aspartic protease of Trichinella spiralis. Vet Parasitol. 2012;190:510-8 pubmed publisher
    In a previous study, we identified an aspartic protease gene (Ts-Asp) from the Trichinella spiralis muscle stage larva cDNA library...
  25. Tanovic A, Fernandez E, Jiménez M. Alterations in intestinal contractility during inflammation are caused by both smooth muscle damage and specific receptor-mediated mechanisms. Croat Med J. 2006;47:318-26 pubmed
    To evaluate motoric intestinal disturbances during inflammation with Trichinella spiralis in rats as an experimental model...
  26. Finkelman F, Shea Donohue T, Morris S, Gildea L, Strait R, Madden K, et al. Interleukin-4- and interleukin-13-mediated host protection against intestinal nematode parasites. Immunol Rev. 2004;201:139-55 pubmed
    ..with mice infected with either of two intestinal nematode parasites, Nippostrongylus brasiliensis or Trichinella spiralis, that evaluate the importance of the Th2 cytokine interleukin-4 (IL-4) and IL-13 in protection against ..
  27. Jung D, Teifke J, Karger A, Michael K, Venz S, Wittmann W, et al. Evaluation of baculovirus-derived recombinant 53-kDa protein of Trichinella spiralis for detection of Trichinella-specific antibodies in domestic pigs by ELISA. Parasitol Res. 2007;100:429-37 pubmed
    The complete gene encoding the 53-kDa protein derived from Trichinella spiralis was cloned and expressed using a baculovirus-based system...
  28. Webb K, Rosenthal B. Deep resequencing of Trichinella spiralis reveals previously un-described single nucleotide polymorphisms and intra-isolate variation within the mitochondrial genome. Infect Genet Evol. 2010;10:304-10 pubmed publisher
    ..Our study affirms that next generation DNA sequencing technology can reliably characterize a complete mitochondrial genome. ..
  29. Gruden Movsesijan A, Ilic N, Mostarica Stojkovic M, Stosic Grujicic S, Milic M, Sofronic Milosavljevic L. Mechanisms of modulation of experimental autoimmune encephalomyelitis by chronic Trichinella spiralis infection in Dark Agouti rats. Parasite Immunol. 2010;32:450-9 pubmed publisher
    b>Trichinella spiralis is a helminth that provokes Th2 and anti-inflammatory type responses in an infected host. Our previous studies using Dark Agouti (DA) rats indicated that T...
  30. Boonmars T, Wu Z, Nagano I, Nakada T, Takahashi Y. Differences and similarities of nurse cells in cysts of Trichinella spiralis and T. pseudospiralis. J Helminthol. 2004;78:7-16 pubmed
    The nurse cell in the cyst of Trichinella spiralis comprises at least two kinds of cytoplasm, derived from muscle or satellite cells, as indicated by the pattern of staining using regular dye (haematoxylin and eosin, or toluidine blue), ..
  31. Serna H, Porras M, Vergara P. Mast cell stabilizer ketotifen [4-(1-methyl-4-piperidylidene)-4h-benzo[4,5]cyclohepta[1,2-b]thiophen-10(9H)-one fumarate] prevents mucosal mast cell hyperplasia and intestinal dysmotility in experimental Trichinella spiralis inflammation in the rat. J Pharmacol Exp Ther. 2006;319:1104-11 pubmed
    b>Trichinella spiralis infection in rats induces hypermotility and an abnormal response to cholecystokinin (CCK) similar to motor disturbances observed in irritable bowel syndrome...
  32. Scales H, Ierna M, Lawrence C. The role of IL-4, IL-13 and IL-4Ralpha in the development of protective and pathological responses to Trichinella spiralis. Parasite Immunol. 2007;29:81-91 pubmed
    ..of the protective and pathological responses induced by infection with the gastrointestinal helminth Trichinella spiralis. IL-4, IL-13 and IL-4Ralpha were required for the generation of Th2 responses to T...
  33. Knight P, Pemberton A, Robertson K, Roy D, Wright S, Miller H. Expression profiling reveals novel innate and inflammatory responses in the jejunal epithelial compartment during infection with Trichinella spiralis. Infect Immun. 2004;72:6076-86 pubmed
    ..chips) and time course kinetics to investigate gene transcription triggered by the intraepithelial nematode Trichinella spiralis in jejunal epithelium from BALB/c mice...
  34. Wu Z, Nagano I, Boonmars T, Takahashi Y. Tumor necrosis factor receptor-mediated apoptosis in Trichinella spiralis-infected muscle cells. Parasitology. 2005;131:373-81 pubmed
    In order to reveal the mechanisms underlying nurse cell formation during Trichinella spiralis infection, the expression of the factors of tumor necrosis factor-alpha (TNF-alpha)/TNF receptor 1 (TNFR-1) signalling pathway mediating ..
  35. Brown J, Knight P, Thornton E, Pate J, Coonrod S, Miller H, et al. Trichinella spiralis induces de novo expression of group IVC phospholipase A2 in the intestinal epithelium. Int J Parasitol. 2008;38:143-7 pubmed
    ..Here, we describe de novo expression of group IVC PLA2 (PLA2g4c) within the intestinal epithelium of Trichinella spiralis parasitised mice...
  36. Bercik P, Wang L, Verdu E, Mao Y, Blennerhassett P, Khan W, et al. Visceral hyperalgesia and intestinal dysmotility in a mouse model of postinfective gut dysfunction. Gastroenterology. 2004;127:179-87 pubmed
    ..Mice infected up to 70 days previously with Trichinella spiralis (Tsp) underwent videofluoroscopy with image analysis to assess upper gastrointestinal motility...
  37. Martínez Gómez F, Fuentes Castro B, Bautista Garfias C. The intraperitoneal inoculation of Lactobacillus casei in mice induces total protection against Trichinella spiralis infection at low challenge doses. Parasitol Res. 2011;109:1609-17 pubmed publisher
    The following effects of Lactobacillus casei in NIH mice were evaluated: the establishment of Trichinella spiralis adult worms in the intestine (AWI), larvae per gram of muscle tissue (LPG), levels of IgG and IgA, and levels of IL-4 and ..
  38. Pemberton A, Knight P, Wright S, Miller H. Proteomic analysis of mouse jejunal epithelium and its response to infection with the intestinal nematode, Trichinella spiralis. Proteomics. 2004;4:1101-8 pubmed
    Infection with the intestinal nematode Trichinella spiralis induces profound, but stereotypic pathological changes to the epithelium, which are common to many nematode infections...
  39. McDermott J, Leslie F, D AMATO M, Thompson D, Grencis R, McLaughlin J. Immune control of food intake: enteroendocrine cells are regulated by CD4+ T lymphocytes during small intestinal inflammation. Gut. 2006;55:492-7 pubmed
    ..We have used a model of upper gut infection (Trichinella spiralis in the mouse) to study the effect of inflammation on food intake, and explored the role of a key ..
  40. Chen X, Yang Y, Yang J, Zhang Z, Zhu X. RNAi-mediated silencing of paramyosin expression in Trichinella spiralis results in impaired viability of the parasite. PLoS ONE. 2012;7:e49913 pubmed publisher
    b>Trichinella spiralis expresses paramyosin (Ts-PMY) not only as a structural protein but also as an immunomodulatory protein to protect the worm from being attacked by host complement components...
  41. Wang Z, Cui J, Xu B. The epidemiology of human trichinellosis in China during 2000-2003. Acta Trop. 2006;97:247-51 pubmed
  42. Casulli A, Morales M, Gallinella B, Turchetto L, Pozio E. 2-Hydroxypropyl-beta-cyclodextrin improves the effectiveness of albendazole against encapsulated larvae of Trichinella spiralis in a murine model. J Antimicrob Chemother. 2006;58:886-90 pubmed
    ..Mice were infected with Trichinella spiralis and treated with albendazole alone, albendazole plus HP-betaCD or not at all (controls) (Experiment I)...
  43. Rafter P, Marucci G, Brangan P, Pozio E. Rediscovery of Trichinella spiralis in red foxes (Vulpes vulpes) in Ireland after 30 years of oblivion. J Infect. 2005;50:61-5 pubmed
    ..7%), Cork County (two foxes; 3.1%), and Waterford County (one fox; 4.2%). All larvae were identified as Trichinella spiralis. The detection of Trichinella-positive foxes in Ireland is an example of how the lack of infections among ..
  44. Gu Y, Li J, Zhu X, Yang J, Li Q, Liu Z, et al. Trichinella spiralis: characterization of phage-displayed specific epitopes and their protective immunity in BALB/c mice. Exp Parasitol. 2008;118:66-74 pubmed
    Trichinellosis is a global zoonosis mainly caused by Trichinella spiralis. We have previously reported that a novel Ts87 gene from the cDNA library of adult T. spiralis was cloned and expressed in a prokaryotic expression system...
  45. Hernández Bello R, Bermúdez Cruz R, Fonseca Liñán R, García Reyna P, Le Guerhier F, Boireau P, et al. Identification, molecular characterisation and differential expression of caveolin-1 in Trichinella spiralis maturing oocytes and embryos. Int J Parasitol. 2008;38:191-202 pubmed
    ..In this work a caveolin-1 gene from the nematode Trichinella spiralis (Ts-cav-1) was cloned and identified as an adult-specific antigen. For this, a cDNA library of T...
  46. Liu M, Wu X, Wang X, Yu Y, Wang W, Chen Q, et al. The functions of Deoxyribonuclease II in immunity and development. DNA Cell Biol. 2008;27:223-8 pubmed publisher
    ..Additionally, enzymes of DNase II family in Trichinella spiralis, which is an intracellular parasitic nematode, are also considered involved in the development of the ..
  47. Kang S, Cho M, Park M, Kim D, Hong Y, Lee Y, et al. Alteration of helper T-cell related cytokine production in splenocytes during Trichinella spiralis infection. Vet Parasitol. 2012;186:319-27 pubmed publisher
    Infection by Trichinella spiralis takes place in two distinct phases: one is the intestinal phase and the other is the muscle phase. To evaluate alterations in cytokine production during a T...
  48. Hernández Bello R, Ramirez Nieto R, Muñiz Hernández S, Nava Castro K, Pavon L, Sánchez Acosta A, et al. Sex steroids effects on the molting process of the helminth human parasite Trichinella spiralis. J Biomed Biotechnol. 2011;2011:625380 pubmed publisher
    ..These findings may have strong implications in the host-parasite coevolution, in the sex-associated susceptibility to this infection and could point out to possibilities to use antihormones to inhibit parasite development. ..
  49. Scalfone L, Nel H, Gagliardo L, Cameron J, Al Shokri S, Leifer C, et al. Participation of MyD88 and interleukin-33 as innate drivers of Th2 immunity to Trichinella spiralis. Infect Immun. 2013;81:1354-63 pubmed publisher
    b>Trichinella spiralis is a highly destructive parasitic nematode that invades and destroys intestinal epithelial cells, injures many different tissues during its migratory phase, and occupies and transforms myotubes during the final phase ..
  50. Beiting D, Bliss S, Schlafer D, Roberts V, Appleton J. Interleukin-10 limits local and body cavity inflammation during infection with muscle-stage Trichinella spiralis. Infect Immun. 2004;72:3129-37 pubmed
    The aim of this study was to characterize cellular responses to muscle-stage Trichinella spiralis. From its intracellular habitat in muscle, T...
  51. Salinas Tobon M, Navarrete Leon A, Mendez Loredo B, Esquivel Aguirre D, Martínez Abrajan D, Hernandez Sanchez J. Trichinella spiralis: strong antibody response to a 49 kDa newborn larva antigen in infected rats. Exp Parasitol. 2007;115:160-7 pubmed
    In this work, we analyzed the kinetics of anti-Trichinella spiralis newborn larva (NBL) antibodies (Ab) and the antigenic recognition pattern of NBL proteins and its dose effects...
  52. Ribicich M, Gamble H, Rosa A, Sommerfelt I, Marquez A, Mira G, et al. Clinical, haematological, biochemical and economic impacts of Trichinella spiralis infection in pigs. Vet Parasitol. 2007;147:265-70 pubmed
    ..was to assess the clinical, haematological and biochemical responses of pigs experimentally inoculated with Trichinella spiralis. Groups of three pigs were inoculated per os with 100, 500 and 5000 T...
  53. Fabre V, Beiting D, Bliss S, Gebreselassie N, Gagliardo L, Lee N, et al. Eosinophil deficiency compromises parasite survival in chronic nematode infection. J Immunol. 2009;182:1577-83 pubmed
    ..The mouse is a natural host for Trichinella spiralis, a worm that establishes chronic infection in skeletal muscle. We tested the influence of eosinophils on T...
  54. Dea Ayuela M, Rama Iñiguez S, Bolas Fernandez F. Contrasting effects of Trichinella spiralis and Trichuris muris antigens on the infection by Leishmania infantum in BALB/c mice. Acta Trop. 2007;103:212-21 pubmed
    The interaction of Trichinella spiralis and Trichuris muris derived antigens with the infection by Leishmania infantum was investigated in BALB/c mice. Infection with 10(6) promastigotes of L...
  55. Yang C, Wei Y, Leng Y, Zhong C, Zhang Y, Wan Y, et al. Vesicular glutamate transporter-3 contributes to visceral hyperalgesia induced by Trichinella spiralis infection in rats. Dig Dis Sci. 2012;57:865-72 pubmed publisher
    ..Transient intestinal infection was effected by oral administration of Trichinella spiralis (T. spiralis) larvae in Brown Norway rats...
  56. Ren H, Cui J, Yang W, Liu R, Wang Z. Identification of differentially expressed genes of Trichinella spiralis larvae after exposure to host intestine milieu. PLoS ONE. 2013;8:e67570 pubmed publisher
    ..The present study provide a group of the potential invasion-related candidate genes and will be helpful for further studies of mechanisms by which T. spiralis infective larvae recognize and invade the intestinal epithelial cells. ..
  57. Wang S, Zhu X, Yang Y, Yang J, Gu Y, Wei J, et al. Molecular cloning and characterization of heat shock protein 70 from Trichinella spiralis. Acta Trop. 2009;110:46-51 pubmed publisher
    A cDNA encoding heat shock protein 70 of Trichinella spiralis (Ts-Hsp70) was identified by immunoscreening the adult T. spiralis cDNA library with rabbit antisera against T. spiralis adult extracts...
  58. Yang J, Gu Y, Yang Y, Wei J, Wang S, Cui S, et al. Trichinella spiralis: immune response and protective immunity elicited by recombinant paramyosin formulated with different adjuvants. Exp Parasitol. 2010;124:403-8 pubmed publisher
    Our previous studies showed that immunization with recombinant paramyosin from Trichinella spiralis (rTs-Pmy) formulated with Freund's adjuvant significantly reduced larval burden in mice after T. spiralis larval challenge...
  59. Leng Y, Wei Y, Chen H, Zhou S, Yang Y, Duan L. Alteration of cholinergic and peptidergic neurotransmitters in rat ileum induced by acute stress following transient intestinal infection is mast cell dependent. Chin Med J (Engl). 2010;123:227-33 pubmed
    ..Transient intestinal infection was initiated by giving 1500 Trichinella spiralis (T.S.) larvae by gavage. ACRS was induced for 2 hours at day 100 PI...
  60. Escalante M, Romaris F, Rodriguez M, Rodríguez E, Leiro J, Gárate M, et al. Evaluation of Trichinella spiralis larva group 1 antigens for serodiagnosis of human trichinellosis. J Clin Microbiol. 2004;42:4060-6 pubmed
    ..i) crude first-stage larval extract (CLE), (ii) O-deglycosylated CLE, (iii) tyvelose-bearing antigens (Trichinella spiralis larva group 1 [TSL-1] antigens) purified by US4 affinity chromatography and coupled directly to enzyme-..
  61. Liu M, Wang X, Fu B, Li C, Wu X, Le Rhun D, et al. Identification of stage-specifically expressed genes of Trichinella spiralis by suppression subtractive hybridization. Parasitology. 2007;134:1443-55 pubmed
    SUMMARYNewborn larvae (NBL) and adult (Ad) stage-specifically expressed genes or members of gene families of Trichinella spiralis were identified by suppression subtractive hybridization (SSH)...
  62. de la Rosa J, Alvarez N, Gomez Priego A. Study of the reproductive capacity of Trichinella spiralis recovered from experimentally infected mice under-dosed with albendazole or mebendazole. Trop Biomed. 2007;24:93-7 pubmed
    The reproductive capacity of Trichinella spiralis recovered from experimentally infected mice under-dosed with albendazole (ALB) or mebendazole (MEB) was studied. Different groups of male C57/BL mice were infected with 10 +/- 0...
  63. Wei J, Gu Y, Yang J, Yang Y, Wang S, Cui S, et al. Identification and characterization of protective epitope of Trichinella spiralis paramyosin. Vaccine. 2011;29:3162-8 pubmed publisher
    b>Trichinella spiralis paramyosin (Ts-Pmy) is a protective antigen that induces partial immunity against T. spiralis infection in mice...
  64. Theodoropoulos G, Petrakos G. Trichinella spiralis: differential effect of host bile on the in vitro invasion of infective larvae into epithelial cells. Exp Parasitol. 2010;126:441-4 pubmed publisher
    ..weight fraction (LMW) was investigated on the in vitro invasion of MDCK-AA7 epithelial cell monolayers by Trichinella spiralis muscle larvae. Seven invasion experiments were performed and a total of 274 cell monolayers were examined...
  65. Mitreva M, Jasmer D, Zarlenga D, Wang Z, Abubucker S, Martin J, et al. The draft genome of the parasitic nematode Trichinella spiralis. Nat Genet. 2011;43:228-35 pubmed publisher
    ..We report a draft genome sequence of Trichinella spiralis, a food-borne zoonotic parasite, which is the most common cause of human trichinellosis...
  66. Angkasekwinai P, Srimanote P, Wang Y, Pootong A, Sakolvaree Y, Pattanapanyasat K, et al. Interleukin-25 (IL-25) promotes efficient protective immunity against Trichinella spiralis infection by enhancing the antigen-specific IL-9 response. Infect Immun. 2013;81:3731-41 pubmed publisher
    ..however, the involvement and underlying mechanisms by which IL-25 mediates immune response against Trichinella spiralis infection have not been investigated...
  67. Siriyasatien P, Yingyourd P, Nuchprayoon S. Efficacy of albendazole against early and late stage of Trichinella spiralis infection in mice. J Med Assoc Thai. 2003;86 Suppl 2:S257-62 pubmed
    Efficacy of albendazole against early and late stage of Trichinella spiralis infection in mice was determined...
  68. Dea Ayuela M, Rama Iñiguez S, Bolas Fernandez F. Vaccination of mice against intestinal Trichinella spiralis infections by oral administration of antigens microencapsulated in methacrilic acid copolymers. Vaccine. 2006;24:2772-80 pubmed
    BALB/c and NIH mice have been successfully vaccinated against the intestinal nematode Trichinella spiralis by oral administration of crude larval extracts (CLE) and excretory-secretory (ES) products derived from first stage T...
  69. Selkirk M, Hussein A, Chambers A, Goulding D, Gares M, Vásquez Lopez C, et al. Trichinella spiralis secretes a homologue of prosaposin. Mol Biochem Parasitol. 2004;135:49-56 pubmed
    Infective larvae and adult stage Trichinella spiralis secrete a protein homologous to prosaposin, the precursor of sphingolipid activator proteins (saposins) A-D originally defined in vertebrates...
  70. Yang Y, Zhang Z, Yang J, Chen X, Cui S, Zhu X. Oral vaccination with Ts87 DNA vaccine delivered by attenuated Salmonella typhimurium elicits a protective immune response against Trichinella spiralis larval challenge. Vaccine. 2010;28:2735-42 pubmed publisher
    We have previously reported that Ts87 is an immunodominant antigen that induces protective immunity against Trichinella spiralis larval challenge...
  71. Liu R, Wang Z, Wang L, Long S, Ren H, Cui J. Analysis of differentially expressed genes of Trichinella spiralis larvae activated by bile and cultured with intestinal epithelial cells using real-time PCR. Parasitol Res. 2013;112:4113-20 pubmed publisher
    The activation of Trichinella spiralis muscle larvae (ML) by exposure to intestinal contents or bile and the intestinal epithelial cells (IECs) themselves are two pivotal requirements for the in vitro larval invasion of IECs...
  72. Martínez Gómez F, Santiago Rosales R, Ramón Bautista Garfias C. Effect of Lactobacillus casei Shirota strain intraperitoneal administration in CD1 mice on the establishment of Trichinella spiralis adult worms and on IgA anti-T. spiralis production. Vet Parasitol. 2009;162:171-5 pubmed publisher
    ..ip) administration of Lactobacillus casei Shirota strain (LcS) in CD1 mice on the establishment of Trichinella spiralis adult worms (TSAW), and on the generation of intestinal IgA anti-T...
  73. Bai X, Wu X, Wang X, Guan Z, Gao F, Yu J, et al. Regulation of cytokine expression in murine macrophages stimulated by excretory/secretory products from Trichinella spiralis in vitro. Mol Cell Biochem. 2012;360:79-88 pubmed publisher
    b>Trichinella spiralis is a zoonotic nematode and food borne parasite and infection with T. spiralis leads to suppression of the host immune response and other immunopathologies. The excretory/secretory (ES) products of T...
  74. Bokken G, Van Eerden E, Opsteegh M, Augustijn M, Graat E, Franssen F, et al. Specific serum antibody responses following a Toxoplasma gondii and Trichinella spiralis co-infection in swine. Vet Parasitol. 2012;184:126-32 pubmed publisher
    The aim of this study was to examine the dynamics of parasite specific antibody development in Trichinella spiralis and Toxoplasma gondii co-infections in pigs and to compare these with antibody dynamics in T. spiralis and T...
  75. Gounaris K, Selkirk M, Sadeghi S. A nucleotidase with unique catalytic properties is secreted by Trichinella spiralis. Mol Biochem Parasitol. 2004;136:257-64 pubmed
    We have isolated and expressed a cDNA from the parasitic nematode Trichinella spiralis encoding a novel secreted nucleotidase which catalyses the hydrolysis of nucleoside 5'-diphosphates and 5'-monophosphates, but not 5'-triphosphates...
  76. Akiho H, Deng Y, Blennerhassett P, Kanbayashi H, Collins S. Mechanisms underlying the maintenance of muscle hypercontractility in a model of postinfective gut dysfunction. Gastroenterology. 2005;129:131-41 pubmed
    ..Here, we investigate the mechanisms underlying the maintenance of this hypercontractility in the postinfective (PI) state...
  77. Bruce A, Gounaris K. Characterisation of a secreted N-acetyl-beta-hexosaminidase from Trichinella spiralis. Mol Biochem Parasitol. 2006;145:84-93 pubmed
    A thorough investigation was conducted for glycoside hydrolase activities in the secreted proteins of Trichinella spiralis. The data demonstrated that the only secreted glycosidase with significant activity was an exo-beta-hexosaminidase ..
  78. Beiting D, Park P, Appleton J. Synthesis of syndecan-1 by skeletal muscle cells is an early response to infection with Trichinella spiralis but is not essential for nurse cell development. Infect Immun. 2006;74:1941-3 pubmed
    b>Trichinella spiralis creates a unique intracellular habitat in striated muscle...
  79. Wu Z, Nagano I, Boonmars T, Takahashi Y. Involvement of the c-Ski oncoprotein in cell cycle arrest and transformation during nurse cell formation after Trichinella spiralis infection. Int J Parasitol. 2006;36:1159-66 pubmed
    The role of c-Ski, an oncoprotein encoded by the oncogene, c-ski, in Trichinella spiralis-infected muscle tissues during nurse cell formation, was investigated by following the expression kinetics and distribution of c-Ski (both protein ..
  80. Kołodziej Sobocińska M, Dvoroznakova E, Dziemian E, Machnicka Rowińska B. Trichinella spiralis reinfection: macrophage activity in BALB/c mice. Parasitol Res. 2007;101:629-37 pubmed
    ..products--nitric oxide (NO) and superoxide anion (O(2) (-))--were examined in BALB/c mice reinfected with Trichinella spiralis. Mice were infected twice with 400 T...
  81. Korinkova K, Kovarcik K, Pavlícková Z, Svoboda M, Koudela B. Serological detection of Trichinella spiralis in swine by ELISA (enzyme-linked immunosorbent assay) using an excretory-secretory (E/S) antigen. Parasitol Res. 2008;102:1317-20 pubmed publisher
    ..compare the specificity and the time of seroconversion of excretory-secretory (E/S) antigens prepared from Trichinella spiralis. A group of eight pigs was inoculated with 500 T...
  82. Park H, Chang S, Kang S, Cho M, Choi S, Hong Y, et al. Expressed sequence tags of Trichinella spiralis muscle stage larvae. Korean J Parasitol. 2008;46:59-63 pubmed publisher
    In order to obtain greater insight into the relevant genomic expression patterns of Trichinella spiralis, 992 expressed sequence tags (ESTs) were collected from a cDNA library of T...
  83. Gabrashanska M, Teodorova S, Petkova S, Mihov L, Anisimova M, Ivanov D. Selenium supplementation at low doses contributes to the antioxidant status in Trichinella spiralis-infected rats. Parasitol Res. 2010;106:561-70 pubmed publisher
    ..The oxidative-antioxidant status of male Wistar rats infected or uninfected with Trichinella spiralis (Nematoda) and supplemented or unsupplemented with Sel-plex (Alltech) was tested through blood biomarkers...
  84. Watanabe N, Matsuda E, Masuda A, Nariai K, Shibasaki T. The effects of fexofenadine on eosinophilia and systemic anaphylaxis in mice infected with Trichinella spiralis. Int Immunopharmacol. 2004;4:367-75 pubmed
    ..The effects of the non-impairing, H(1)-receptor antagonist fexofenadine were investigated in in vivo mouse models of eosinophilia and systemic anaphylaxis...
  85. Pemberton A, Knight P, Gamble J, Colledge W, Lee J, Pierce M, et al. Innate BALB/c enteric epithelial responses to Trichinella spiralis: inducible expression of a novel goblet cell lectin, intelectin-2, and its natural deletion in C57BL/10 mice. J Immunol. 2004;173:1894-901 pubmed
    Infection of mice with the nematode parasite Trichinella spiralis induces changes in the proteome of the jejunal epithelium, including substantial up-regulation of a novel variant of interlectin...
  86. Scales H, Ierna M, Gutierrez Ramos J, Coyle A, Garside P, Lawrence C. Effect of inducible costimulator blockade on the pathological and protective immune responses induced by the gastrointestinal helminth Trichinella spiralis. Eur J Immunol. 2004;34:2854-62 pubmed
    ..However, during expulsion of Trichinella spiralis this Th2 response also induces a severe enteropathy characterized by villus atrophy and crypt hyperplasia...
  87. Boonmars T, Wu Z, Nagano I, Takahashi Y. What is the role of p53 during the cyst formation of Trichinella spiralis ? A comparable study between knockout mice and wild type mice. Parasitology. 2005;131:705-12 pubmed
    During the cyst formation of Trichinella spiralis, the infected muscle cell undergoes basophilic change and apoptosis, which results in nurse cell formation...
  88. Rodríguez E, Olmedo J, Ubeira F, Blanco C, Garate T. Mixed infection, Trichinella spiralis and Trichinella britovi, in a wild boar hunted in the Province of Cáceres (Spain). Exp Parasitol. 2008;119:430-2 pubmed publisher
    ..In Spain, two morphologically indistinguishable Trichinella species have been described--Trichinella spiralis and Trichinella britovi--that are perpetuated in both domestic and sylvatic cycles...
  89. Ren H, Cui J, Wang Z, Liu R. Normal mouse intestinal epithelial cells as a model for the in vitro invasion of Trichinella spiralis infective larvae. PLoS ONE. 2011;6:e27010 pubmed publisher
    It has been known for many years that Trichinella spiralis initiates infection by penetrating the columnar epithelium of the small intestine; however, the mechanisms used by the parasite in the establishment of its intramulticellular ..
  90. Randazzo V, La Sala L, Costamagna S. [Effect of temperature on the viability of Trichinella spiralis larvae]. Rev Argent Microbiol. 2011;43:256-62 pubmed publisher
    The aim of this work was to study the effect of temperature on the viability of free and encysted larvae of Trichinella spiralis from southwest Buenos Aires province, Argentina...
  91. Ren H, Liu R, Wang Z, Cui J. Construction and use of a Trichinella spiralis phage display library to identify the interactions between parasite and host enterocytes. Parasitol Res. 2013;112:1857-63 pubmed publisher
    Although it has been known for many years that Trichinella spiralis initiates infection by penetrating the columnar epithelium of the small intestine, the mechanisms by which T...
  92. Aguayo Ortiz R, Méndez Lucio O, Medina Franco J, Castillo R, Yepez Mulia L, Hernández Luis F, et al. Towards the identification of the binding site of benzimidazoles to ?-tubulin of Trichinella spiralis: insights from computational and experimental data. J Mol Graph Model. 2013;41:12-9 pubmed publisher
    ..By using the amino acid sequence of Trichinella spiralis ?-tubulin as a basis and by applying homology modeling techniques, we were able to build a 3D structure of ..