hydra

Summary

Summary: A genus of freshwater polyps in the family Hydridae, order Hydroida, class HYDROZOA. They are of special interest because of their complex organization and because their adult organization corresponds roughly to the gastrula of higher animals.

Top Publications

  1. Chapman J, Kirkness E, Simakov O, Hampson S, Mitros T, Weinmaier T, et al. The dynamic genome of Hydra. Nature. 2010;464:592-6 pubmed publisher
    The freshwater cnidarian Hydra was first described in 1702 and has been the object of study for 300 years...
  2. Sun H, Rodin A, Zhou Y, Dickinson D, Harper D, Hewett Emmett D, et al. Evolution of paired domains: isolation and sequencing of jellyfish and hydra Pax genes related to Pax-5 and Pax-6. Proc Natl Acad Sci U S A. 1997;94:5156-61 pubmed
    ..In addition, the complete cDNA sequences of hydra Pax-A and -B were obtained...
  3. Soriano J, Colombo C, Ott A. Hydra molecular network reaches criticality at the symmetry-breaking axis-defining moment. Phys Rev Lett. 2006;97:258102 pubmed
    We study biological, multicellular symmetry breaking on a hollow cell sphere as it occurs during hydra regeneration from a random cell aggregate...
  4. Bosch T, Augustin R, Gellner K, Khalturin K, Lohmann J. In vivo electroporation for genetic manipulations of whole Hydra polyps. Differentiation. 2002;70:140-7 pubmed
    In vivo electroporation is used to study gene regulation and gene function in the freshwater polyp Hydra. Although this approach has been used successfully by several investigators, efficacy and handling continue to present a problem...
  5. Pauly B, Stiening B, Schade M, Alexandrova O, Zoubek R, David C, et al. Molecular cloning and cellular distribution of two 14-3-3 isoforms from Hydra: 14-3-3 proteins respond to starvation and bind to phosphorylated targets. Exp Cell Res. 2003;285:15-26 pubmed
    In the simple metazoan Hydra a clear link between food supply and cell survival has been established...
  6. Takahashi T, Hamaue N. Molecular characterization of Hydra acetylcholinesterase and its catalytic activity. FEBS Lett. 2010;584:511-6 pubmed publisher
    A full-length cDNA encoding an acetylcholinesterase (AChE) from Hydra magnipapillata was isolated...
  7. Fraune S, Augustin R, Anton Erxleben F, Wittlieb J, Gelhaus C, Klimovich V, et al. In an early branching metazoan, bacterial colonization of the embryo is controlled by maternal antimicrobial peptides. Proc Natl Acad Sci U S A. 2010;107:18067-72 pubmed publisher
    ..Here we show that early embryonic stages of the basal metazoan Hydra are able to control bacterial colonization by using maternal antimicrobial peptides...
  8. Franzenburg S, Fraune S, Künzel S, Baines J, Domazet Loso T, Bosch T. MyD88-deficient Hydra reveal an ancient function of TLR signaling in sensing bacterial colonizers. Proc Natl Acad Sci U S A. 2012;109:19374-9 pubmed publisher
    ..In basal metazoans such as the cnidarians Hydra magnipapillata and Nematostella vectensis, all components of the vertebrate TLR signaling cascade are present, but ..
  9. Lange C, Hemmrich G, Klostermeier U, López Quintero J, Miller D, Rahn T, et al. Defining the origins of the NOD-like receptor system at the base of animal evolution. Mol Biol Evol. 2011;28:1687-702 pubmed publisher
    ..combinations of domains, and the number of one specific type (NB-ARC and tetratricopeptide repeat containing) in Hydra is particularly large...

More Information

Publications156 found, 100 shown here

  1. Kawaida H, Ohba K, Koutake Y, Shimizu H, Tachida H, Kobayakawa Y. Symbiosis between hydra and chlorella: molecular phylogenetic analysis and experimental study provide insight into its origin and evolution. Mol Phylogenet Evol. 2013;66:906-14 pubmed publisher
    Although many physiological studies have been reported on the symbiosis between hydra and green algae, very little information from a molecular phylogenetic aspect of symbiosis is available...
  2. Holdway D, Lok K, Semaan M. The acute and chronic toxicity of cadmium and zinc to two hydra species. Environ Toxicol. 2001;16:557-65 pubmed
    The potential of two hydra species, Hydra vulgaris (pink) and Hydra viridissima (green), for use as invertebrate models for toxicity testing of waterborne metals was investigated...
  3. Milbradt A, Boulegue C, Moroder L, Renner C. The two cysteine-rich head domains of minicollagen from Hydra nematocysts differ in their cystine framework and overall fold despite an identical cysteine sequence pattern. J Mol Biol. 2005;354:591-600 pubmed
    ..Minicollagen-1 from the nematocysts of Hydra is a trimeric protein that contains cysteine-rich domains at the N and C termini, which are involved in the ..
  4. Boehm A, Khalturin K, Anton Erxleben F, Hemmrich G, Klostermeier U, López Quintero J, et al. FoxO is a critical regulator of stem cell maintenance in immortal Hydra. Proc Natl Acad Sci U S A. 2012;109:19697-702 pubmed publisher
    b>Hydra's unlimited life span has long attracted attention from natural scientists. The reason for that phenomenon is the indefinite self-renewal capacity of its stem cells. The underlying molecular mechanisms have yet to be explored...
  5. Mochizuki K, Sano H, Kobayashi S, Nishimiya Fujisawa C, Fujisawa T. Expression and evolutionary conservation of nanos-related genes in Hydra. Dev Genes Evol. 2000;210:591-602 pubmed
    ..We cloned two nanos (nos)-related genes, Cnnos1 and Cnnos2 from Hydra magnipapillata. Using whole-mount in situ hybridization, the expression of Cnnos1 and Cnnos2 was examined...
  6. Augustin R, Siebert S, Bosch T. Identification of a kazal-type serine protease inhibitor with potent anti-staphylococcal activity as part of Hydra's innate immune system. Dev Comp Immunol. 2009;33:830-7 pubmed publisher
    In the absence of migratory phagocytic cells the basal metazoan Hydra has developed a very effective immune system...
  7. Thomsen S, Bosch T. Foot differentiation and genomic plasticity in Hydra: lessons from the PPOD gene family. Dev Genes Evol. 2006;216:57-68 pubmed
    In Hydra, developmental processes are permanently active to maintain a simple body plan consisting of a two-layered, radially symmetrical tube with two differentiated structures, head and foot...
  8. Miller D, Hemmrich G, Ball E, Hayward D, Khalturin K, Funayama N, et al. The innate immune repertoire in cnidaria--ancestral complexity and stochastic gene loss. Genome Biol. 2007;8:R59 pubmed
    ..Recently, whole genome sequences became available for two cnidarians, Hydra magnipapillata and Nematostella vectensis, and large expressed sequence tag (EST) datasets are available for these ..
  9. Takahashi T, Fujisawa T. Peptidomic approaches to the identification and characterization of functional peptides in Hydra. Methods Mol Biol. 2010;615:275-92 pubmed publisher
    ..The cnidarian Hydra is one of the most basal metazoans and is a key model system for studying the peptides involved in these processes...
  10. Chera S, de Rosa R, Miljkovic Licina M, Dobretz K, Ghila L, Kaloulis K, et al. Silencing of the hydra serine protease inhibitor Kazal1 gene mimics the human SPINK1 pancreatic phenotype. J Cell Sci. 2006;119:846-57 pubmed
    In hydra, the endodermal epithelial cells carry out the digestive function together with the gland cells that produce zymogens and express the evolutionarily conserved gene Kazal1...
  11. Augustin R, Franke A, Khalturin K, Kiko R, Siebert S, Hemmrich G, et al. Dickkopf related genes are components of the positional value gradient in Hydra. Dev Biol. 2006;296:62-70 pubmed publisher
    b>Hydra is a classical model organism to understand fundamental developmental biological processes such as regeneration and axis formation...
  12. Quinn B, Gagné F, Blaise C. An investigation into the acute and chronic toxicity of eleven pharmaceuticals (and their solvents) found in wastewater effluent on the cnidarian, Hydra attenuata. Sci Total Environ. 2008;389:306-14 pubmed
    ..Lawrence river, were tested for acute and chronic toxicity using the cnidarian Hydra attenuata...
  13. Steele R. The Hydra genome: insights, puzzles and opportunities for developmental biologists. Int J Dev Biol. 2012;56:535-42 pubmed
    The sequencing of a Hydra genome marked the beginning of a new era in the use of Hydra as a developmental model...
  14. Golubovic A, Kuhn A, Williamson M, Kalbacher H, Holstein T, Grimmelikhuijzen C, et al. A peptide-gated ion channel from the freshwater polyp Hydra. J Biol Chem. 2007;282:35098-103 pubmed publisher
    ..Here we report cloning from the freshwater cnidarian Hydra of a novel ion channel (Hydra sodium channel, HyNaC) that is directly gated by the neuropeptides Hydra-RFamides I ..
  15. Technau U, Cramer von Laue C, Rentzsch F, Luft S, Hobmayer B, Bode H, et al. Parameters of self-organization in Hydra aggregates. Proc Natl Acad Sci U S A. 2000;97:12127-31 pubmed
    ..Cells isolated from the simple metazoan Hydra can aggregate and form a complete animal by self-organization...
  16. Ladokhin A, Haigler H. Reversible transition between the surface trimer and membrane-inserted monomer of annexin 12. Biochemistry. 2005;44:3402-9 pubmed
    ..This reversibility, in combination with the absence of oligomerization in the water-soluble and inserted state, makes ANX a good experimental model for thermodynamic studies of folding and stability of membrane proteins. ..
  17. Anton Erxleben F, Thomas A, Wittlieb J, Fraune S, Bosch T. Plasticity of epithelial cell shape in response to upstream signals: a whole-organism study using transgenic Hydra. Zoology (Jena). 2009;112:185-94 pubmed publisher
    ..One of the simplest multicellular organisms is the freshwater polyp Hydra. Although much is known about patterning in this early branching metazoan, there is currently little understanding ..
  18. Malvindi M, Carbone L, Quarta A, Tino A, Manna L, Pellegrino T, et al. Rod-shaped nanocrystals elicit neuronal activity in vivo. Small. 2008;4:1747-55 pubmed publisher
    ..Here it is reported that challenging the small cnidaria Hydra vulgaris in vivo with rod-shaped semiconductor nanoparticles, also known as quantum rods (QRs), results in an ..
  19. Broun M, Sokol S, Bode H. Cngsc, a homologue of goosecoid, participates in the patterning of the head, and is expressed in the organizer region of Hydra. Development. 1999;126:5245-54 pubmed
    We have isolated Cngsc, a hydra homologue of goosecoid gene. The homeodomain of Cngsc is identical to the vertebrate (65-72%) and Drosophila (70%) orthologues...
  20. Chera S, Kaloulis K, Galliot B. The cAMP response element binding protein (CREB) as an integrative HUB selector in metazoans: clues from the hydra model system. Biosystems. 2007;87:191-203 pubmed
    ..In hydra, the CREB pathway is highly conserved and activated during early head regeneration through RSK-dependent CREB ..
  21. Sher D, Fishman Y, Melamed Book N, Zhang M, Zlotkin E. Osmotically driven prey disintegration in the gastrovascular cavity of the green hydra by a pore-forming protein. FASEB J. 2008;22:207-14 pubmed
    ..We recently isolated and characterized Hydralysins (Hlns), paralytic PFPs from the venomous green hydra Chlorohydra viridissima that are not found within the nematocytes, suggesting they are not involved in prey ..
  22. Suga H, Koyanagi M, Hoshiyama D, Ono K, Iwabe N, Kuma K, et al. Extensive gene duplication in the early evolution of animals before the parazoan-eumetazoan split demonstrated by G proteins and protein tyrosine kinases from sponge and hydra. J Mol Evol. 1999;48:646-53 pubmed
    ..subunit (Galpha) and the protein tyrosine kinase (PTK) cDNAs from Ephydatia fluviatilis (freshwater sponge) and Hydra magnipapillata strain 105 (hydra). We obtained 13 Galpha and 20 PTK cDNAs...
  23. Chandramore K, Ghaskadbi S. Evo-devo: Hydra raises its Noggin. J Biosci. 2011;36:517-29 pubmed
    ..We have studied the evolutionary origin of BMP-Noggin antagonism in hydra, which is a powerful diploblastic model to study evolution of pattern-forming mechanisms because of the unusual ..
  24. Zhang M, Fishman Y, Sher D, Zlotkin E. Hydralysin, a novel animal group-selective paralytic and cytolytic protein from a noncnidocystic origin in hydra. Biochemistry. 2003;42:8939-44 pubmed
    ..In this study, a new paralysis-inducing (neurotoxic) protein from the green hydra Chlorohydra viridissima was purified, cloned, and expressed...
  25. Pauly B, Lasi M, MacKintosh C, Morrice N, Imhof A, Regula J, et al. Proteomic screen in the simple metazoan Hydra identifies 14-3-3 binding proteins implicated in cellular metabolism, cytoskeletal organisation and Ca2+ signalling. BMC Cell Biol. 2007;8:31 pubmed publisher
    ..We found that the simple metazoan Hydra has four 14-3-3 isoforms...
  26. Rieu J, Upadhyaya A, Glazier J, Ouchi N, Sawada Y. Diffusion and deformations of single hydra cells in cellular aggregates. Biophys J. 2000;79:1903-14 pubmed
    ..We used confocal microscopy to study the center of mass displacements and deformations of single endodermal Hydra cells in two kinds of cellular aggregates, ectodermal and endodermal...
  27. Habetha M, Bosch T. Symbiotic Hydra express a plant-like peroxidase gene during oogenesis. J Exp Biol. 2005;208:2157-65 pubmed
    ..In the Cnidarian Hydra viridis, symbiotic algae of the genus Chlorella are located in endodermal epithelial cells and impact sexual ..
  28. Plachetzki D, Fong C, Oakley T. The evolution of phototransduction from an ancestral cyclic nucleotide gated pathway. Proc Biol Sci. 2010;277:1963-9 pubmed publisher
    ..Transcripts of a CNG ion channel co-localize with opsin in specific cell types of the eyeless cnidarian Hydra magnipapillata. Further, the CNG inhibitor cis-diltiazem ablates a stereotypical photoresponse in the hydra...
  29. Martinez D, Iñiguez A, Percell K, Willner J, Signorovitch J, Campbell R. Phylogeny and biogeography of Hydra (Cnidaria: Hydridae) using mitochondrial and nuclear DNA sequences. Mol Phylogenet Evol. 2010;57:403-10 pubmed publisher
    The polyp hydra is ubiquitous in freshwater and is highly variable, with many species names assigned to different strains...
  30. Takahashi T, Hayakawa E, Koizumi O, Fujisawa T. Neuropeptides and their functions in Hydra. Acta Biol Hung. 2008;59 Suppl:227-35 pubmed publisher
    ..molecules involved in the regulation of developmental and physiological processes in the freshwater cnidarian, Hydra magnipapillata, we initiated a systematic peptide screening project, the Hydra Peptide Project...
  31. Jung S, Dingley A, Augustin R, Anton Erxleben F, Stanisak M, Gelhaus C, et al. Hydramacin-1, structure and antibacterial activity of a protein from the basal metazoan Hydra. J Biol Chem. 2009;284:1896-905 pubmed publisher
    ..antimicrobial protein recently discovered during investigations of the epithelial defense of the ancient metazoan Hydra. The amino acid sequence of hydramacin-1 shows no sequence homology to any known antimicrobial proteins...
  32. Tortiglione C, Quarta A, Tino A, Manna L, Cingolani R, Pellegrino T. Synthesis and biological assay of GSH functionalized fluorescent quantum dots for staining Hydra vulgaris. Bioconjug Chem. 2007;18:829-35 pubmed
    ..and we prove how these functionalized fluorescent probes can be used for staining a freshwater invertebrate called Hydra vulgaris. GSH is known to promote Hydra feeding response by inducing mouth opening...
  33. Grens A, Shimizu H, Hoffmeister S, Bode H, Fujisawa T. The novel signal peptides, pedibin and Hym-346, lower positional value thereby enhancing foot formation in hydra. Development. 1999;126:517-24 pubmed
    ..Two novel peptides, pedibin and Hym-346, that are closely related to one another have been isolated from Hydra vulgaris and Hydra magnipapillata...
  34. Hobmayer B, Rentzsch F, Kuhn K, Happel C, von Laue C, Snyder P, et al. WNT signalling molecules act in axis formation in the diploblastic metazoan Hydra. Nature. 2000;407:186-9 pubmed publisher
    ..characterization of members of the Wnt signalling pathway--Wnt, Dishevelled, GSK3, beta-Catenin and Tcf/Lef--in Hydra, a member of the evolutionarily old metazoan phylum Cnidaria...
  35. Alexandrova O, Solovei I, Cremer T, David C. Replication labeling patterns and chromosome territories typical of mammalian nuclei are conserved in the early metazoan Hydra. Chromosoma. 2003;112:190-200 pubmed
    ..previously described for mammalian cells we have analyzed the nuclear architecture of the simple polyp Hydra. These diploblastic organisms have large nuclei (8-10 microm) containing about 3x10(9) bp of DNA organized in 15 ..
  36. Fröbius A, Genikhovich G, Kürn U, Anton Erxleben F, Bosch T. Expression of developmental genes during early embryogenesis of Hydra. Dev Genes Evol. 2003;213:445-55 pubmed
    b>Hydra is a classical model to study key features of embryogenesis such as axial patterning and stem cell differentiation...
  37. Reinhardt B, Broun M, Blitz I, Bode H. HyBMP5-8b, a BMP5-8 orthologue, acts during axial patterning and tentacle formation in hydra. Dev Biol. 2004;267:43-59 pubmed
    Developmental gradients play a central role in axial patterning in hydra. As part of the effort towards elucidating the molecular basis of these gradients as well as investigating the evolution of the mechanisms underlying axial ..
  38. Hamaguchi Hamada K, Fujisawa Y, Koizumi O, Muneoka Y, Okado N, Hamada S. Immunohistochemical evidence for the existence of novel mammalian neuropeptides related to the Hydra GLW-amide neuropeptide family. Cell Tissue Res. 2009;337:15-25 pubmed publisher
    ..These results strongly suggest that the rat nervous system contains as yet unidentified GLW-amide-like peptides, and that GLW-amide-LI in the brain is a good marker for ascending projections from mesopontine cholinergic neurons. ..
  39. Augustin R, Fraune S, Bosch T. How Hydra senses and destroys microbes. Semin Immunol. 2010;22:54-8 pubmed publisher
    ..revealed that the basic templates of innate immune sensors were laid down in ancient animals such as the cnidarian Hydra. Important functions of Hydra's innate immune sensors and effectors include not only protection against pathogens ..
  40. Ostroumova T, Markova L. The effects of dopamine synthesis inhibitors and dopamine antagonists on regeneration in the hydra Hydra attenuata. Neurosci Behav Physiol. 2002;32:293-8 pubmed
    ..receptor blockers (haloperidol and spiperone) on the regeneration of apical, gastral, and basal fragments of the hydra Hydra attenuata were studied...
  41. Koizumi O. Nerve ring of the hypostome in hydra: is it an origin of the central nervous system of bilaterian animals?. Brain Behav Evol. 2007;69:151-9 pubmed
    A hypothesis, 'the nerve ring in hydra shares a common origin with the central nervous system in bilaterian animals', is discussed in this review...
  42. Rentzsch F, Guder C, Vocke D, Hobmayer B, Holstein T. An ancient chordin-like gene in organizer formation of Hydra. Proc Natl Acad Sci U S A. 2007;104:3249-54 pubmed
    ..Here we describe a Chordin-like molecule (HyChdl) from Hydra that inhibits BMP activity in zebrafish embryos and acts in Hydra axis formation when new head organizers are ..
  43. Frank U, Leitz T, Muller W. The hydroid Hydractinia: a versatile, informative cnidarian representative. Bioessays. 2001;23:963-71 pubmed
    ..representative, Hydractinia offers many practical and theoretical advantages: studies that are feasible in Hydra like regeneration, pattern regulation, and cell renewal from stem cells, can be supplemented by genetic analyses ..
  44. Stout T, McFarland T, Appukuttan B. Suppression subtractive hybridization identifies novel transcripts in regenerating Hydra littoralis. J Biochem Mol Biol. 2007;40:286-9 pubmed
    ..In a Hydra littoralis model of regeneration, we employed a rapid shotgun suppression subtractive hybridization strategy to ..
  45. Lasi M, David C, Böttger A. Apoptosis in pre-Bilaterians: Hydra as a model. Apoptosis. 2010;15:269-78 pubmed publisher
    b>Hydra is a member of the ancient metazoan phylum Cnidaria and is an especially well investigated model organism for questions of the evolutionary origin of metazoan processes...
  46. Gauchat D, Mazet F, Berney C, Schummer M, Kreger S, Pawlowski J, et al. Evolution of Antp-class genes and differential expression of Hydra Hox/paraHox genes in anterior patterning. Proc Natl Acad Sci U S A. 2000;97:4493-8 pubmed
    ..Intermediate Hox/paraHox genes (PG 3 to 8 and lox) did not have clear cnidarian counterparts. In Hydra, cnox-1, cnox-2, and cnox-3 were not found chromosomally linked within a 150-kb range and displayed specific ..
  47. Takahashi T, Hatta M, Yum S, Gee L, Ohtani M, Fujisawa T, et al. Hym-301, a novel peptide, regulates the number of tentacles formed in hydra. Development. 2005;132:2225-34 pubmed
    Hym-301 is a peptide that was discovered as part of a project aimed at isolating novel peptides from hydra. We have isolated and characterized the gene Hym-301, which encodes this peptide...
  48. Rentzsch F, Hobmayer B, Holstein T. Glycogen synthase kinase 3 has a proapoptotic function in Hydra gametogenesis. Dev Biol. 2005;278:1-12 pubmed
    ..function of the major negative regulator of this pathway, GSK3 (glycogen synthase kinase 3), in the basal metazoan Hydra. Microinjection assays reveal that HyGSK3 inhibits beta-catenin in zebrafish embryos, indicating that the function ..
  49. Voigt O, Erpenbeck D, W rheide G. A fragmented metazoan organellar genome: the two mitochondrial chromosomes of Hydra magnipapillata. BMC Genomics. 2008;9:350 pubmed publisher
    ..In the genus Hydra, the mt genome comprises one or two mt chromosomes...
  50. Nakamura Y, Tsiairis C, Ozbek S, Holstein T. Autoregulatory and repressive inputs localize Hydra Wnt3 to the head organizer. Proc Natl Acad Sci U S A. 2011;108:9137-42 pubmed publisher
    ..Here we find in the cnidarian Hydra that two functionally distinct cis-regulatory elements control the head organizer-associated Hydra Wnt3 (HyWnt3)...
  51. Balasubramanian P, BECKMANN A, Warnken U, Schnolzer M, Schuler A, Bornberg Bauer E, et al. Proteome of Hydra nematocyst. J Biol Chem. 2012;287:9672-81 pubmed publisher
    ..Here, we describe the proteome of nematocysts from the freshwater polyp Hydra magnipapillata...
  52. Shimizu H, Fujisawa T. Peduncle of Hydra and the heart of higher organisms share a common ancestral origin. Genesis. 2003;36:182-6 pubmed
    The heart is assumed to have evolved as the organ for pumping blood. Here we report a pumping phenomenon in Hydra, a member of the phylum Cnidaria...
  53. Hwang J, Takaku Y, Momose T, Adamczyk P, Ozbek S, Ikeo K, et al. Nematogalectin, a nematocyst protein with GlyXY and galectin domains, demonstrates nematocyte-specific alternative splicing in Hydra. Proc Natl Acad Sci U S A. 2010;107:18539-44 pubmed publisher
    ..such genes arise and participate in morphological evolution, we have investigated a gene called nematogalectin in Hydra, which has a structural role in the formation of nematocysts, stinging organelles that are unique to the phylum ..
  54. Galliot B. Hydra, a fruitful model system for 270 years. Int J Dev Biol. 2012;56:411-23 pubmed
    The discovery of Hydra regeneration by Abraham Trembley in 1744 promoted much scientific curiosity thanks to his clever design of experimental strategies away from the natural environment...
  55. Horibata Y, Sakaguchi K, Okino N, Iida H, Inagaki M, Fujisawa T, et al. Unique catabolic pathway of glycosphingolipids in a hydrozoan, Hydra magnipapillata, involving endoglycoceramidase. J Biol Chem. 2004;279:33379-89 pubmed publisher
    ..strong EGCase activity in animals belonging to Cnidaria, Mollusca, and Annelida and cloned the enzyme from a hydra, Hydra magnipapillata. The hydra EGCase, consisting of 517 amino acid residues, showed 19.2% and 50...
  56. Guder C, Pinho S, Nacak T, Schmidt H, Hobmayer B, Niehrs C, et al. An ancient Wnt-Dickkopf antagonism in Hydra. Development. 2006;133:901-11 pubmed publisher
    ..from a regeneration-specific signal peptide screen, of a novel dickkopf gene from the fresh water cnidarian Hydra. Comparative sequence analysis demonstrates that the Wnt antagonistic subfamily Dkk1/Dkk2/Dkk4 and the non-..
  57. Böttger A, Alexandrova O. Programmed cell death in Hydra. Semin Cancer Biol. 2007;17:134-46 pubmed
    b>Hydra is one of the simplest metazoans and thus an important model organism for studies on the evolution of developmental mechanisms in multi-cellular animals...
  58. Adamczyk P, Meier S, Gross T, Hobmayer B, Grzesiek S, Bachinger H, et al. Minicollagen-15, a novel minicollagen isolated from Hydra, forms tubule structures in nematocysts. J Mol Biol. 2008;376:1008-20 pubmed publisher
    ..Here, we report the cloning and characterization of a novel minicollagen in Hydra, designated minicollagen-15 (NCol-15)...
  59. Kawaida H, Shimizu H, Fujisawa T, Tachida H, Kobayakawa Y. Molecular phylogenetic study in genus Hydra. Gene. 2010;468:30-40 pubmed publisher
    Among 8000-9000 species of Cnidaria, only several dozens of species of Hydrozoa have been found in the fresh water. Hydra is such a fresh water polyp and has been used as a good material for research in developmental biology, ..
  60. Philipp I, Holstein T, Hobmayer B. HvJNK, a Hydra member of the c-Jun NH2-terminal kinase gene family, is expressed during nematocyte differentiation. Gene Expr Patterns. 2005;5:397-402 pubmed publisher
    ..We report here the characterization of a highly conserved Hydra JNK orthologue (HvJNK) that exhibits amino acid sequence identity of 61% as compared with human JNK1alpha...
  61. Bielen H, Oberleitner S, Marcellini S, Gee L, Lemaire P, Bode H, et al. Divergent functions of two ancient Hydra Brachyury paralogues suggest specific roles for their C-terminal domains in tissue fate induction. Development. 2007;134:4187-97 pubmed publisher
    ..In the diploblast Hydra, the Brachyury homologue HyBra1 acts early in the formation of the hypostome, the location of the organiser in ..
  62. Dash B, Metz R, Huebner H, Porter W, Phillips T. Molecular characterization of two superoxide dismutases from Hydra vulgaris. Gene. 2007;387:93-108 pubmed publisher
    ..for manganese superoxide dismutase (HvMnSOD) and extracellular superoxide dismutase (HvEC-SOD) were isolated from Hydra vulgaris in order to understand their expression and 3D structures; and explore their possibility of being used as ..
  63. Khalturin K, Anton Erxleben F, Milde S, Plötz C, Wittlieb J, Hemmrich G, et al. Transgenic stem cells in Hydra reveal an early evolutionary origin for key elements controlling self-renewal and differentiation. Dev Biol. 2007;309:32-44 pubmed
    ..To characterize the regulatory events that control stem cells in the basal metazoan Hydra, we have generated transgenics which express eGFP selectively in the interstitial stem cell lineage...
  64. Hwang J, Takaku Y, Chapman J, Ikeo K, David C, Gojobori T. Cilium evolution: identification of a novel protein, nematocilin, in the mechanosensory cilium of Hydra nematocytes. Mol Biol Evol. 2008;25:2009-17 pubmed publisher
    The cnidocil at the apical end of Hydra nematocytes is a mechanosensory cilium, which acts as a "trigger" for discharge of the nematocyst capsule...
  65. Hartl M, Mitterstiller A, Valovka T, Breuker K, Hobmayer B, Bister K. Stem cell-specific activation of an ancestral myc protooncogene with conserved basic functions in the early metazoan Hydra. Proc Natl Acad Sci U S A. 2010;107:4051-6 pubmed publisher
    ..and extensively characterized ancestral forms of myc and max genes from the early diploblastic cnidarian Hydra, the most primitive metazoan organism employed so far for the structural, functional, and evolutionary analysis of ..
  66. Grens A, Gee L, Fisher D, Bode H. CnNK-2, an NK-2 homeobox gene, has a role in patterning the basal end of the axis in hydra. Dev Biol. 1996;180:473-88 pubmed
    ..Here we describe the characterization of the NK-2 homolog CnNK-2 from Hydra vulgaris, a freshwater cnidarian...
  67. Bode H. Head regeneration in Hydra. Dev Dyn. 2003;226:225-36 pubmed
    b>Hydra, a primitive metazoan, has a simple structure consisting of a head, body column, and foot aligned along a single oral-aboral axis. The body column has a high capacity for regeneration of both the head and foot...
  68. Gauchat D, Escriva H, Miljkovic Licina M, Chera S, Langlois M, Begue A, et al. The orphan COUP-TF nuclear receptors are markers for neurogenesis from cnidarians to vertebrates. Dev Biol. 2004;275:104-23 pubmed
    In bilaterians, COUP-TF nuclear receptors participate in neurogenesis and/or CNS patterning. In hydra, the nervous system is formed of sensory mechanoreceptor cells (nematocytes) and neuronal cells, both lineages deriving from a common ..
  69. Fujisawa T. Hydra peptide project 1993-2007. Dev Growth Differ. 2008;50 Suppl 1:S257-68 pubmed publisher
    A systematic screening of peptide signaling molecules (<5000 da) in Hydra magnipapillata (the Hydra Peptide Project) was launched in 1993 and at least the first phase of the project ended in 2007...
  70. Buzgariu W, Chera S, Galliot B. Methods to investigate autophagy during starvation and regeneration in hydra. Methods Enzymol. 2008;451:409-37 pubmed publisher
    In hydra, the regulation of the balance between cell death and cell survival is essential to maintain homeostasis across the animal and promote animal survival during starvation...
  71. Watanabe H, Hoang V, Mättner R, Holstein T. Immortality and the base of multicellular life: Lessons from cnidarian stem cells. Semin Cell Dev Biol. 2009;20:1114-25 pubmed publisher
    ..The genomes of Hydra and Nematostella, representatives of two major cnidarian classes indicate a surprising complexity of both genomes, ..
  72. Bosch T, Anton Erxleben F, Hemmrich G, Khalturin K. The Hydra polyp: nothing but an active stem cell community. Dev Growth Differ. 2010;52:15-25 pubmed publisher
    b>Hydra is a powerful stem cell model because its potential immortality and extensive regeneration capacity is due to the presence of three distinct stem cell lineages...
  73. Münder S, Käsbauer T, Prexl A, Aufschnaiter R, Zhang X, Towb P, et al. Notch signalling defines critical boundary during budding in Hydra. Dev Biol. 2010;344:331-45 pubmed publisher
    ..The boundary between parent and bud during asexual reproduction in the fresh water polyp Hydra vulgaris is an example...
  74. Hemmrich G, Khalturin K, Boehm A, Puchert M, Anton Erxleben F, Wittlieb J, et al. Molecular signatures of the three stem cell lineages in hydra and the emergence of stem cell function at the base of multicellularity. Mol Biol Evol. 2012;29:3267-80 pubmed publisher
    ..In this study, using transgenic Hydra polyps, we reveal for each of the three stem cell populations a specific signature set of transcriptions factors ..
  75. Bode H. The head organizer in Hydra. Int J Dev Biol. 2012;56:473-8 pubmed
    ..The presence and activity of an organizer was first described in adult Hydra about 100 years ago, and in the following decades organizer regions were identified in a number of bilaterian ..
  76. Hobmayer E, Hatta M, Fischer R, Fujisawa T, Holstein T, Sugiyama T. Identification of a Hydra homologue of the beta-catenin/plakoglobin/armadillo gene family. Gene. 1996;172:155-9 pubmed
    ..Here, we describe the isolation and characterization of a beta-catenin (beta Ctn) homologue from Hydra magnipapillata, a diploblastic lower metazoan...
  77. Martinez D. Mortality patterns suggest lack of senescence in hydra. Exp Gerontol. 1998;33:217-25 pubmed
    ..There has been much controversy, however, about the potential immortality of hydra, a solitary freshwater member of the phylum Cnidaria, one of the earliest diverging metazoan groups...
  78. Karntanut W, Pascoe D. The toxicity of copper, cadmium and zinc to four different Hydra (Cnidaria: Hydrozoa). Chemosphere. 2002;47:1059-64 pubmed
    An acute toxicity study of three metals to Hydra species carried out using two different assessment methods, (i) determination of the LC50 and (ii) measurement of progressive morphological changes, demonstrated that relative toxicity ..
  79. Fedders H, Augustin R, Bosch T. A Dickkopf- 3-related gene is expressed in differentiating nematocytes in the basal metazoan Hydra. Dev Genes Evol. 2004;214:72-80 pubmed
    ..a Dickkopf gene with a deduced amino acid sequence closely related to that of chicken Dkk-3 in the basal metazoan Hydra. HyDkk-3 appears to be the only Dickkopf gene in Hydra...
  80. Kurz E, Holstein T, Petri B, Engel J, David C. Mini-collagens in hydra nematocytes. J Cell Biol. 1991;115:1159-69 pubmed
    ..c-DNA clones (N-COL 1, N-COL 2, N-COL 3, N-COL 4) that are highly expressed in developing nematocytes in hydra. All four c-DNAs as well as their corresponding transcripts are small in size (600-1,000 bp)...
  81. Kuznetsov S, Anton Erxleben F, Bosch T. Epithelial interactions in Hydra: apoptosis in interspecies grafts is induced by detachment from the extracellular matrix. J Exp Biol. 2002;205:3809-17 pubmed
    ..By grafting epithelia of different species we have previously shown that the freshwater polyp Hydra eliminates non-self cells by phagocytosis...
  82. Sher D, Knebel A, Bsor T, Nesher N, Tal T, Morgenstern D, et al. Toxic polypeptides of the hydra--a bioinformatic approach to cnidarian allomones. Toxicon. 2005;45:865-79 pubmed
    ..A large-scale EST database from Hydra magnipapillata was searched for orthologs of known cnidarian allomones, as well as for allomones found in other ..
  83. Böttger A, Strasser D, Alexandrova O, Levin A, Fischer S, Lasi M, et al. Genetic screen for signal peptides in Hydra reveals novel secreted proteins and evidence for non-classical protein secretion. Eur J Cell Biol. 2006;85:1107-17 pubmed
    We have screened a Hydra cDNA library for sequences encoding N-terminal signal peptides using the yeast invertase secretion vector pSUC [Jacobs et al., 1997. A genetic selection for isolating cDNAs encoding secreted proteins...
  84. Hemmrich G, Anokhin B, Zacharias H, Bosch T. Molecular phylogenetics in Hydra, a classical model in evolutionary developmental biology. Mol Phylogenet Evol. 2007;44:281-90 pubmed
    Among the earliest diverging animal phyla are the Cnidaria. Freshwater polyps of the genus Hydra (Cnidaria, Hydrozoa) have long been of general interest because different species of Hydra reveal fundamental principles that underlie ..
  85. K sbauer T, Towb P, Alexandrova O, David C, Dall armi E, Staudigl A, et al. The Notch signaling pathway in the cnidarian Hydra. Dev Biol. 2007;303:376-90 pubmed publisher
    ..We show here that Notch signaling is also conserved in these early metazoans. We describe the Hydra Notch receptor (HvNotch) and provide evidence for the conservation of the Notch signaling mode via regulated ..
  86. Darmer D, Hauser F, Nothacker H, Bosch T, Williamson M, Grimmelikhuijzen C. Three different prohormones yield a variety of Hydra-RFamide (Arg-Phe-NH2) neuropeptides in Hydra magnipapillata. Biochem J. 1998;332 ( Pt 2):403-12 pubmed
    The freshwater polyp Hydra is the most frequently used model for the study of development in cnidarians. Recently we isolated four novel Arg-Phe-NH2 (RFamide) neuropeptides, the Hydra-RFamides I-IV, from Hydra magnipapillata...
  87. Engel U, Ozbek S, Streitwolf Engel R, Petri B, Lottspeich F, Holstein T, et al. Nowa, a novel protein with minicollagen Cys-rich domains, is involved in nematocyst formation in Hydra. J Cell Sci. 2002;115:3923-34 pubmed
    The novel protein Nowa was identified in nematocysts, explosive organelles of Hydra, jellyfish, corals and other CNIDARIA: Biogenesis of these organelles is complex and involves assembly of proteins inside a post-Golgi vesicle to form a ..
  88. Technau U, Miller M, Bridge D, Steele R. Arrested apoptosis of nurse cells during Hydra oogenesis and embryogenesis. Dev Biol. 2003;260:191-206 pubmed
    During Hydra oogenesis, an aggregate of germ cells differentiates into one oocyte and thousands of nurse cells. Nurse cells display a number of features typical of apoptotic cells and are phagocytosed by the growing oocyte...
  89. Zhang X, Boot Handford R, Huxley Jones J, Forse L, Mould A, Robertson D, et al. The collagens of hydra provide insight into the evolution of metazoan extracellular matrices. J Biol Chem. 2007;282:6792-802 pubmed publisher
    ..The thick sheet-like extracellular matrix (mesoglia) of the diploblast, hydra, has characteristics of both a basement membrane and an interstitial matrix...
  90. Bosch T. Hydra and the evolution of stem cells. Bioessays. 2009;31:478-86 pubmed publisher
    b>Hydra are remarkable because they are immortal. Much of immortality can be ascribed to the asexual mode of reproduction by budding, which requires a tissue consisting of stem cells with continuous self-renewal capacity...
  91. Takahashi T, Fujisawa T. Important roles for epithelial cell peptides in hydra development. Bioessays. 2009;31:610-9 pubmed publisher
    ..In Hydra, there is circumstantial evidence that small diffusible molecules act as morphogens in the regulation of ..
  92. Reddy P, Bidaye S, Ghaskadbi S. Genome-wide screening reveals the emergence and divergence of RTK homologues in basal Metazoan Hydra magnipapillata. J Biosci. 2011;36:289-96 pubmed
    ..We have carried out the present study in hydra, a diploblast, to investigate the divergence of RTKs after parazoa and before emergence of triploblast phyla...