manduca

Summary

Summary: A genus of sphinx or hawk moths of the family Sphingidae. These insects are used in molecular biology studies during all stages of their life cycle.

Top Publications

  1. Verspui R, Gray J. Visual stimuli induced by self-motion and object-motion modify odour-guided flight of male moths (Manduca sexta L.). J Exp Biol. 2009;212:3272-82 pubmed publisher
    ..The mechanisms underlying olfactory and visual integration are discussed in the context of these behavioural responses. ..
  2. An C, Kanost M. Manduca sexta serpin-5 regulates prophenoloxidase activation and the Toll signaling pathway by inhibiting hemolymph proteinase HP6. Insect Biochem Mol Biol. 2010;40:683-9 pubmed publisher
    ..b>Manduca sexta hemolymph proteinase-6 (HP6) is a component of both pathways...
  3. Allmann S, Baldwin I. Insects betray themselves in nature to predators by rapid isomerization of green leaf volatiles. Science. 2010;329:1075-8 pubmed publisher
    ..We found that Manduca sexta-infested Nicotiana attenuata attract the generalist hemipteran predator Geocoris spp...
  4. Zavala J, Giri A, Jongsma M, Baldwin I. Digestive duet: midgut digestive proteinases of Manduca sexta ingesting Nicotiana attenuata with manipulated trypsin proteinase inhibitor expression. PLoS ONE. 2008;3:e2008 pubmed publisher
    The defensive effect of endogenous trypsin proteinase inhibitors (NaTPIs) on the herbivore Manduca sexta was demonstrated by genetically altering NaTPI production in M. sexta's host plant, Nicotiana attenuata...
  5. Jassbi A, Gase K, Hettenhausen C, Schmidt A, Baldwin I. Silencing geranylgeranyl diphosphate synthase in Nicotiana attenuata dramatically impairs resistance to tobacco hornworm. Plant Physiol. 2008;146:974-86 pubmed
    ..HGL-DTGs) of Nicotiana attenuata function as antifeedants for the plant's adapted herbivore, tobacco hornworm (Manduca sexta)...
  6. Grosse Wilde E, Kuebler L, Bucks S, Vogel H, Wicher D, Hansson B. Antennal transcriptome of Manduca sexta. Proc Natl Acad Sci U S A. 2011;108:7449-54 pubmed publisher
    ..behavioral repertoire and nonexistent ecological importance of Bombyx, molecular data on the tobacco hornworm Manduca sexta are of utmost importance, especially with regards to its position as a classical olfactory model and its ..
  7. Patch H, Velarde R, Walden K, Robertson H. A candidate pheromone receptor and two odorant receptors of the hawkmoth Manduca sexta. Chem Senses. 2009;34:305-16 pubmed publisher
    In this study, we cloned and characterized three Manduca sexta odorant receptors (ORs). One receptor is a putative pheromone receptor expressed exclusively in a cell associated with male-specific type-I trichoid sensilla...
  8. Halitschke R, Hamilton J, Kessler A. Herbivore-specific elicitation of photosynthesis by mirid bug salivary secretions in the wild tobacco Nicotiana attenuata. New Phytol. 2011;191:528-35 pubmed publisher
    ..While feeding by Manduca sexta larvae results in a strong down-regulation of photosynthesis, we demonstrate a specific induction of ..
  9. Kariyat R, Mauck K, Balogh C, Stephenson A, Mescher M, De Moraes C. Inbreeding in horsenettle (Solanum carolinense) alters night-time volatile emissions that guide oviposition by Manduca sexta moths. Proc Biol Sci. 2013;280:20130020 pubmed publisher
    ..during the dark phase of the photoperiod, and the effects of this variation on the oviposition preferences of Manduca sexta moths, whose larvae are specialist herbivores of Solanaceae...
  10. Hettenhausen C, Baldwin I, Wu J. Nicotiana attenuata MPK4 suppresses a novel jasmonic acid (JA) signaling-independent defense pathway against the specialist insect Manduca sexta, but is not required for the resistance to the generalist Spodoptera littoralis. New Phytol. 2013;199:787-99 pubmed publisher
    ..kinase (MAPK), MPK4, in the resistance of a wild tobacco Nicotiana attenuata to two herbivores, the specialist Manduca sexta and the generalist Spodoptera littoralis. Stably transformed N...

Detail Information

Publications153 found, 100 shown here

  1. Verspui R, Gray J. Visual stimuli induced by self-motion and object-motion modify odour-guided flight of male moths (Manduca sexta L.). J Exp Biol. 2009;212:3272-82 pubmed publisher
    ..The mechanisms underlying olfactory and visual integration are discussed in the context of these behavioural responses. ..
  2. An C, Kanost M. Manduca sexta serpin-5 regulates prophenoloxidase activation and the Toll signaling pathway by inhibiting hemolymph proteinase HP6. Insect Biochem Mol Biol. 2010;40:683-9 pubmed publisher
    ..b>Manduca sexta hemolymph proteinase-6 (HP6) is a component of both pathways...
  3. Allmann S, Baldwin I. Insects betray themselves in nature to predators by rapid isomerization of green leaf volatiles. Science. 2010;329:1075-8 pubmed publisher
    ..We found that Manduca sexta-infested Nicotiana attenuata attract the generalist hemipteran predator Geocoris spp...
  4. Zavala J, Giri A, Jongsma M, Baldwin I. Digestive duet: midgut digestive proteinases of Manduca sexta ingesting Nicotiana attenuata with manipulated trypsin proteinase inhibitor expression. PLoS ONE. 2008;3:e2008 pubmed publisher
    The defensive effect of endogenous trypsin proteinase inhibitors (NaTPIs) on the herbivore Manduca sexta was demonstrated by genetically altering NaTPI production in M. sexta's host plant, Nicotiana attenuata...
  5. Jassbi A, Gase K, Hettenhausen C, Schmidt A, Baldwin I. Silencing geranylgeranyl diphosphate synthase in Nicotiana attenuata dramatically impairs resistance to tobacco hornworm. Plant Physiol. 2008;146:974-86 pubmed
    ..HGL-DTGs) of Nicotiana attenuata function as antifeedants for the plant's adapted herbivore, tobacco hornworm (Manduca sexta)...
  6. Grosse Wilde E, Kuebler L, Bucks S, Vogel H, Wicher D, Hansson B. Antennal transcriptome of Manduca sexta. Proc Natl Acad Sci U S A. 2011;108:7449-54 pubmed publisher
    ..behavioral repertoire and nonexistent ecological importance of Bombyx, molecular data on the tobacco hornworm Manduca sexta are of utmost importance, especially with regards to its position as a classical olfactory model and its ..
  7. Patch H, Velarde R, Walden K, Robertson H. A candidate pheromone receptor and two odorant receptors of the hawkmoth Manduca sexta. Chem Senses. 2009;34:305-16 pubmed publisher
    In this study, we cloned and characterized three Manduca sexta odorant receptors (ORs). One receptor is a putative pheromone receptor expressed exclusively in a cell associated with male-specific type-I trichoid sensilla...
  8. Halitschke R, Hamilton J, Kessler A. Herbivore-specific elicitation of photosynthesis by mirid bug salivary secretions in the wild tobacco Nicotiana attenuata. New Phytol. 2011;191:528-35 pubmed publisher
    ..While feeding by Manduca sexta larvae results in a strong down-regulation of photosynthesis, we demonstrate a specific induction of ..
  9. Kariyat R, Mauck K, Balogh C, Stephenson A, Mescher M, De Moraes C. Inbreeding in horsenettle (Solanum carolinense) alters night-time volatile emissions that guide oviposition by Manduca sexta moths. Proc Biol Sci. 2013;280:20130020 pubmed publisher
    ..during the dark phase of the photoperiod, and the effects of this variation on the oviposition preferences of Manduca sexta moths, whose larvae are specialist herbivores of Solanaceae...
  10. Hettenhausen C, Baldwin I, Wu J. Nicotiana attenuata MPK4 suppresses a novel jasmonic acid (JA) signaling-independent defense pathway against the specialist insect Manduca sexta, but is not required for the resistance to the generalist Spodoptera littoralis. New Phytol. 2013;199:787-99 pubmed publisher
    ..kinase (MAPK), MPK4, in the resistance of a wild tobacco Nicotiana attenuata to two herbivores, the specialist Manduca sexta and the generalist Spodoptera littoralis. Stably transformed N...
  11. Furusawa T, Rakwal R, Nam H, Hirano M, Shibato J, Kim Y, et al. Systematic investigation of the hemolymph proteome of Manduca sexta at the fifth instar larvae stage using one- and two-dimensional proteomics platforms. J Proteome Res. 2008;7:938-59 pubmed publisher
    b>Manduca sexta is an excellent insect model for studying insect physiology, including hemolymph proteins. Larvae stages of this insect are highly damaging to tobacco leaves causing a drastic decrease in crop yield...
  12. Hiruma K, Riddiford L. The molecular mechanisms of cuticular melanization: the ecdysone cascade leading to dopa decarboxylase expression in Manduca sexta. Insect Biochem Mol Biol. 2009;39:245-53 pubmed publisher
    ..action of 20-hydroxyecdysone on various transcription factors leading to DDC expression at the end of a larval molt in Manduca sexta. In addition, the ecdysone cascade found in M. sexta is compared with that of other organisms.
  13. Porta H, Jiménez G, Cordoba E, Leon P, Soberon M, Bravo A. Tobacco plants expressing the Cry1AbMod toxin suppress tolerance to Cry1Ab toxin of Manduca sexta cadherin-silenced larvae. Insect Biochem Mol Biol. 2011;41:513-9 pubmed publisher
    ..form oligomeric structures without binding to cadherin receptor and were shown to be toxic to cadherin-silenced Manduca sexta larvae and Pectinophora gossypiella strain with resistance linked to mutations in a cadherin gene...
  14. Greenlee K, Socha J, Eubanks H, PEDERSEN P, Lee W, Kirkton S. Hypoxia-induced compression in the tracheal system of the tobacco hornworm caterpillar, Manduca sexta. J Exp Biol. 2013;216:2293-301 pubmed publisher
    ..Using synchrotron X-ray imaging in conjunction with high-speed flow-through respirometry, we show that Manduca sexta caterpillars cyclically contract their bodies in response to hypoxia, resulting in significant compressions ..
  15. Garriga M, Caballero J. Insights into the structure of urea-like compounds as inhibitors of the juvenile hormone epoxide hydrolase (JHEH) of the tobacco hornworm Manduca sexta: analysis of the binding modes and structure-activity relationships of the inhibitors by docking a. Chemosphere. 2011;82:1604-13 pubmed publisher
    ..are well-known as potent inhibitors of juvenile hormone epoxide hydrolase (JHEH) of the tobacco hornworm Manduca sexta...
  16. Effmert U, Dinse C, Piechulla B. Influence of green leaf herbivory by Manduca sexta on floral volatile emission by Nicotiana suaveolens. Plant Physiol. 2008;146:1996-2007 pubmed publisher
    ..Nicotiana suaveolens plants were challenged with Manduca sexta feeding on leaves, and alterations in the quality and quantity of the floral blend, shifts in emission ..
  17. Gunaratna R, Jiang H. A comprehensive analysis of the Manduca sexta immunotranscriptome. Dev Comp Immunol. 2013;39:388-98 pubmed publisher
    As a biochemical model, Manduca sexta has substantially contributed to our knowledge on insect innate immunity. The RNA-Seq approach was implemented in three studies to examine tissue immunotranscriptomes of this species...
  18. Zhuang S, Kelo L, Nardi J, Kanost M. Neuroglian on hemocyte surfaces is involved in homophilic and heterophilic interactions of the innate immune system of Manduca sexta. Dev Comp Immunol. 2007;31:1159-67 pubmed
    ..adhesion molecules (L1-CAMs), is expressed on surfaces of granular cells and a subset of large plasmatocytes of Manduca sexta that act as foci for hemocyte aggregation during the innate immune response...
  19. Beetz S, Holthusen T, Koolman J, Trenczek T. Correlation of hemocyte counts with different developmental parameters during the last larval instar of the tobacco hornworm, Manduca sexta. Arch Insect Biochem Physiol. 2008;67:63-75 pubmed
    We determined the changes in hemocyte titer and in the abundance of hemocyte types of the tobacco hornworm Manduca sexta during the fourth and fifth larval stadium and the beginning of the pupal stadium...
  20. Zhu Y, Ragan E, Kanost M. Leureptin: a soluble, extracellular leucine-rich repeat protein from Manduca sexta that binds lipopolysaccharide. Insect Biochem Mol Biol. 2010;40:713-22 pubmed publisher
    ..of leureptin, a novel extracellular protein with 13 leucine-rich repeats from hemolymph of the insect Manduca sexta...
  21. van der Hoeven R, Betrabet G, Forst S. Characterization of the gut bacterial community in Manduca sexta and effect of antibiotics on bacterial diversity and nematode reproduction. FEMS Microbiol Lett. 2008;286:249-56 pubmed publisher
    The tobacco hornworm, Manduca sexta, is a model lepidopteran insect used to study the pathogenic and mutualistic phases of entomopathogenic nematodes (EPNs) and their bacterial symbionts...
  22. Sumathipala N, Jiang H. Involvement of Manduca sexta peptidoglycan recognition protein-1 in the recognition of bacteria and activation of prophenoloxidase system. Insect Biochem Mol Biol. 2010;40:487-95 pubmed publisher
    ..other insect species, such a role has not yet been experimentally established for PGRPs in the tobacco hornworm, Manduca sexta. In this study, we purified M...
  23. Balkenius A, Bisch Knaden S, Hansson B. Interaction of visual and odour cues in the mushroom body of the hawkmoth Manduca sexta. J Exp Biol. 2009;212:535-41 pubmed publisher
    ..of odour and colour were recorded using calcium-sensitive optical imaging in the mushroom bodies of the hawkmoth Manduca sexta. The results show that the activity in the mushroom bodies is influenced by both olfaction and vision...
  24. Flecke C, Stengl M. Octopamine and tyramine modulate pheromone-sensitive olfactory sensilla of the hawkmoth Manduca sexta in a time-dependent manner. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2009;195:529-45 pubmed publisher
    In moths octopamine improved pheromone-dependent mate search time dependently. In the nocturnal hawkmoth Manduca sexta long-term tip recordings of trichoid sensilla were performed to investigate whether biogenic amines modulate pheromone ..
  25. Pauchet Y, Muck A, Svatos A, Heckel D. Chromatographic and electrophoretic resolution of proteins and protein complexes from the larval midgut microvilli of Manduca sexta. Insect Biochem Mol Biol. 2009;39:467-74 pubmed publisher
    The microvillar proteome of Manduca sexta larval midguts was analyzed by subjecting brush border membrane vesicles (BBMV) to two different two-dimensional approaches: (i) Anion exchange chromatography followed by SDS-PAGE and (ii) Blue ..
  26. Horodyski F, Verlinden H, Filkin N, Vandersmissen H, Fleury C, Reynolds S, et al. Isolation and functional characterization of an allatotropin receptor from Manduca sexta. Insect Biochem Mol Biol. 2011;41:804-14 pubmed publisher
    b>Manduca sexta allatotropin (Manse-AT) is a multifunctional neuropeptide whose actions include the stimulation of juvenile hormone biosynthesis, myotropic stimulation, cardioacceleratory functions, and inhibition of active ion transport...
  27. Matousková P, Pichova I, Svatos A. Functional characterization of a desaturase from the tobacco hornworm moth (Manduca sexta) with bifunctional Z11- and 10,12-desaturase activity. Insect Biochem Mol Biol. 2007;37:601-10 pubmed
    The pheromone blend produced by the tobacco hornworm moth (Manduca sexta) (L.) female is unusually complex and contains two conjugated dienals and trienals together with two monounsaturated alkenals...
  28. von Dahl C, Winz R, Halitschke R, Kuhnemann F, Gase K, Baldwin I. Tuning the herbivore-induced ethylene burst: the role of transcript accumulation and ethylene perception in Nicotiana attenuata. Plant J. 2007;51:293-307 pubmed
    ..We demonstrate that fatty acid-amino acid conjugates are the responsible elicitors in Manduca sexta OS, and identify genes that are important in OS-elicited ethylene biosynthesis and perception in the larvae'..
  29. Zhang S, Gunaratna R, Zhang X, Najar F, Wang Y, Roe B, et al. Pyrosequencing-based expression profiling and identification of differentially regulated genes from Manduca sexta, a lepidopteran model insect. Insect Biochem Mol Biol. 2011;41:733-46 pubmed publisher
    Although Manduca sexta has significantly contributed to our knowledge on a variety of insect physiological processes, the lack of its genome sequence hampers the large-scale gene discovery, transcript profiling, and proteomic analysis in ..
  30. Balkenius A, Hansson B. Discrimination training with multimodal stimuli changes activity in the mushroom body of the hawkmoth Manduca sexta. PLoS ONE. 2012;7:e32133 pubmed publisher
    ..Functional imaging was used to investigate changes in the in vivo responses of the mushroom body of the hawkmoth Manduca sexta during multimodal discrimination training...
  31. Ao J, Ling E, Yu X. A Toll receptor from Manduca sexta is in response to Escherichia coli infection. Mol Immunol. 2008;45:543-52 pubmed
    Genomic and cDNA sequences of a Toll receptor were cloned from the tobacco hornworm, Manduca sexta. M. sexta Toll (MsToll) gene contains six introns and seven exons...
  32. Nardi J, Bee C, Miller L, Mathur D, Ohlstein B. Cell renewal in adjoining intestinal and tracheal epithelia of Manduca. J Insect Physiol. 2011;57:487-93 pubmed publisher
    ..Tracheal regenerative cells and their neighboring midgut regenerative cells proliferate and differentiate in concert during the coordinated growth of the midgut and its associated muscles, nerves and tracheal cells. ..
  33. Zhang L, Oh Y, Li H, Baldwin I, Galis I. Alternative oxidase in resistance to biotic stresses: Nicotiana attenuata AOX contributes to resistance to a pathogen and a piercing-sucking insect but not Manduca sexta larvae. Plant Physiol. 2012;160:1453-67 pubmed publisher
    ..Wild-type and irAOX plants were independently challenged with (1) chewing herbivores (Manduca sexta), (2) piercing-sucking insects (Empoasca spp...
  34. Drexler A, Harris C, dela Pena M, Asuncion Uchi M, Chung S, Webster S, et al. Molecular characterization and cell-specific expression of an ion transport peptide in the tobacco hornworm, Manduca sexta. Cell Tissue Res. 2007;329:391-408 pubmed
    ..This fragment was amplified from larval cDNA of the tobacco hornworm, Manduca sexta and showed a high degree of sequence conservation with the same region from other insects and, to a lesser ..
  35. Elliott G, Zeidler M. MsSOCS expression indicates a potential role for JAK/STAT signalling in the early stages of Manduca sexta spermatogenesis. Insect Mol Biol. 2008;17:475-83 pubmed publisher
    ..Here we present the first detailed examination of the testes stem cell niche in the lepidopteran Manduca sexta ...
  36. Vierk R, Pflueger H, Duch C. Differential effects of octopamine and tyramine on the central pattern generator for Manduca flight. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2009;195:265-77 pubmed publisher
    ..In this study, we tested whether tyramine affected the central pattern generator for flight in the moth, Manduca sexta...
  37. An C, Ishibashi J, Ragan E, Jiang H, Kanost M. Functions of Manduca sexta hemolymph proteinases HP6 and HP8 in two innate immune pathways. J Biol Chem. 2009;284:19716-26 pubmed publisher
    ..We have identified more than 20 serine proteinases in hemolymph of the tobacco hornworm, Manduca sexta, but functions are known for only a few of them. We report here functions of two additional M...
  38. Johnston P, Crickmore N. Gut bacteria are not required for the insecticidal activity of Bacillus thuringiensis toward the tobacco hornworm, Manduca sexta. Appl Environ Microbiol. 2009;75:5094-9 pubmed publisher
    ..for the insecticidal activity of the Bacillus thuringiensis-based insecticide, DiPel, toward the lepidopterans Manduca sexta, Pieris rapae, Vanessa cardui, and Lymantria dispar...
  39. Kumar P, Pandit S, Baldwin I. Tobacco rattle virus vector: A rapid and transient means of silencing manduca sexta genes by plant mediated RNA interference. PLoS ONE. 2012;7:e31347 pubmed publisher
    ..plant Nicotiana attenuata to transiently silence midgut genes of the plant's lepidopteran specialist herbivore, Manduca sexta. To compare the efficacy of longer, undiced dsRNA for insect gene silencing, we silenced N...
  40. Garbutt J, Belles X, Richards E, Reynolds S. Persistence of double-stranded RNA in insect hemolymph as a potential determiner of RNA interference success: evidence from Manduca sexta and Blattella germanica. J Insect Physiol. 2013;59:171-8 pubmed publisher
    ..by RNAi and experimentally investigate the dynamics of dsRNA persistence in two insects, the tobacco hornworm, Manduca sexta, a species in which experimental difficulty has been experienced with RNAi protocols and the German ..
  41. Glendinning J, Jerud A, Reinherz A. The hungry caterpillar: an analysis of how carbohydrates stimulate feeding in Manduca sexta. J Exp Biol. 2007;210:3054-67 pubmed
    In most insects, the taste of carbohydrates stimulates an immediate appetitive response. The caterpillar of Manduca sexta is an exception to this general pattern...
  42. Abdel Latief M, Hilker M. Innate immunity: eggs of Manduca sexta are able to respond to parasitism by Trichogramma evanescens. Insect Biochem Mol Biol. 2008;38:136-45 pubmed publisher
    ..We investigated whether transcription of immune related genes in eggs of Manduca sexta changed in response to parasitism by Trichogramma evanescens...
  43. Dolzer J, Krannich S, Stengl M. Pharmacological investigation of protein kinase C- and cGMP-dependent ion channels in cultured olfactory receptor neurons of the hawkmoth Manduca sexta. Chem Senses. 2008;33:803-13 pubmed publisher
    In the hawkmoth Manduca sexta, pheromone stimuli of different strength and duration rise the intracellular Ca2+ concentration in olfactory receptor neurons (ORNs)...
  44. Meldau S, Wu J, Baldwin I. Silencing two herbivory-activated MAP kinases, SIPK and WIPK, does not increase Nicotiana attenuata's susceptibility to herbivores in the glasshouse and in nature. New Phytol. 2009;181:161-73 pubmed publisher
    Salicylic acid-induced protein kinase (SIPK) and wound-induced protein kinase (WIPK) are activated by Manduca sexta attack and elicitors to mediate defense signaling in Nicotiana attenuata...
  45. Li Y, Wang Y, Jiang H, Deng J. Crystal structure of Manduca sexta prophenoloxidase provides insights into the mechanism of type 3 copper enzymes. Proc Natl Acad Sci U S A. 2009;106:17002-6 pubmed publisher
    ..97 A, which is the initial structure for a PPO from the type 3 copper protein family. Manduca sexta PPO is a heterodimer consisting of 2 homologous polypeptide chains, PPO1 and PPO2...
  46. Daly K, Carrell L, Mwilaria E. Characterizing psychophysical measures of discrimination thresholds and the effects of concentration on discrimination learning in the moth Manduca sexta. Chem Senses. 2008;33:95-106 pubmed
    ..Here, we establish these thresholds for a panel of odors using a Pavlovian paradigm in the moth Manduca sexta...
  47. Pacheco S, Gomez I, Gill S, Bravo A, Soberon M. Enhancement of insecticidal activity of Bacillus thuringiensis Cry1A toxins by fragments of a toxin-binding cadherin correlates with oligomer formation. Peptides. 2009;30:583-8 pubmed publisher
    ..Cry1A toxins interact with three regions of the Manduca sexta cadherin receptor that are located in CR7, CR11 and CR12 cadherin repeats...
  48. Stemmler E, Bruns E, Cashman C, Dickinson P, Christie A. Molecular and mass spectral identification of the broadly conserved decapod crustacean neuropeptide pQIRYHQCYFNPISCF: the first PISCF-allatostatin (Manduca sexta- or C-type allatostatin) from a non-insect. Gen Comp Endocrinol. 2010;165:1-10 pubmed publisher
    The PISCF-allatostatins (Manduca sexta- or C-type allatostatins) are a family of pentadecapeptides characterized by a pyroglutamine blocked N-terminus, an unamidated-PISCF C-terminus, and a disulfide bridge between two internal Cys ..
  49. Utz S, Huetteroth W, Wegener C, Kahnt J, Predel R, Schachtner J. Direct peptide profiling of lateral cell groups of the antennal lobes of Manduca sexta reveals specific composition and changes in neuropeptide expression during development. Dev Neurobiol. 2007;67:764-77 pubmed
    ..In the sphinx moth Manduca sexta, like in other holometabolous insects, they are formed during metamorphosis...
  50. Zhuang S, Kelo L, Nardi J, Kanost M. Multiple alpha subunits of integrin are involved in cell-mediated responses of the Manduca immune system. Dev Comp Immunol. 2008;32:365-79 pubmed
    ..of the immunoglobulin (Ig) superfamily (neuroglian) are involved in the encapsulation response of hemocytes in Manduca sexta. In addition, two new integrin alpha (alpha) subunits have been found on these hemocytes...
  51. Hu X, Murata L, Weichsel A, Brailey J, Roberts S, Nighorn A, et al. Allostery in recombinant soluble guanylyl cyclase from Manduca sexta. J Biol Chem. 2008;283:20968-77 pubmed publisher
    ..We have expressed heterodimeric full-length and N-terminal fragments of Manduca sexta sGC in Escherichia coli, the first time this has been accomplished for any sGC, and have performed the ..
  52. An C, Jiang H, Kanost M. Proteolytic activation and function of the cytokine Spätzle in the innate immune response of a lepidopteran insect, Manduca sexta. FEBS J. 2010;277:148-62 pubmed publisher
    ..We have investigated the function of Spätzle in a lepidopteran insect, Manduca sexta, in which hemolymph proteinases activated during immune responses have been characterized biochemically...
  53. Steppuhn A, Schuman M, Baldwin I. Silencing jasmonate signalling and jasmonate-mediated defences reveals different survival strategies between two Nicotiana attenuata accessions. Mol Ecol. 2008;17:3717-32 pubmed publisher
    ..Transient silencing of JA biosynthesis increased Manduca sexta larval growth on wild type (WT) plants of both accessions, but not on TPI-deficient UT or nicotine-..
  54. An C, Ragan E, Kanost M. Serpin-1 splicing isoform J inhibits the proSpätzle-activating proteinase HP8 to regulate expression of antimicrobial hemolymph proteins in Manduca sexta. Dev Comp Immunol. 2011;35:135-41 pubmed publisher
    ..In the tobacco hornworm, Manduca sexta, hemolymph proteinase 8 (HP8) promotes the synthesis of antimicrobial proteins by cleaving proSpätzle, the ..
  55. Reisenman C, Dacks A, Hildebrand J. Local interneuron diversity in the primary olfactory center of the moth Manduca sexta. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2011;197:653-65 pubmed publisher
    ..and neurotransmitter content of LNs in the antennal lobe (AL, the insect primary olfactory center) of the moth Manduca sexta. We found that most LNs are broadly tuned, with all LNs responding to at least one odorant...
  56. Bonaventure G, VanDoorn A, Baldwin I. Herbivore-associated elicitors: FAC signaling and metabolism. Trends Plant Sci. 2011;16:294-9 pubmed publisher
    ..The interaction between Nicotiana attenuata and the specialist lepidopteran Manduca sexta presents a relevant biological system to understand HAE perception and signal transduction systems in ..
  57. Valavanis C, Wang Z, Sun D, Vaine M, Schwartz L. Acheron, a novel member of the Lupus Antigen family, is induced during the programmed cell death of skeletal muscles in the moth Manduca sexta. Gene. 2007;393:101-9 pubmed
    ..screening protocol to isolate cDNAs that were induced when the intersegmental muscles (ISM) of the moth Manduca sexta become committed to die at the end of metamorphosis...
  58. Huss M, Wieczorek H. Influence of ATP and ADP on dissociation of the V-ATPase into its V(1) and V(O) complexes. FEBS Lett. 2007;581:5566-72 pubmed
    ..the endogenous nucleotide content of the V(1)V(O) holoenzyme and of the V(1) complex, both purified from Manduca sexta larval midgut, we found that the V(1) complex contained 1.7 molec. of ADP, whereas only 0.3 molec...
  59. Wu J, Wang L, Baldwin I. Methyl jasmonate-elicited herbivore resistance: does MeJA function as a signal without being hydrolyzed to JA?. Planta. 2008;227:1161-8 pubmed publisher
    ..levels of nicotine and trypsin proteinase inhibitors (TPIs) and resistance to larvae of the specialist herbivore, Manduca sexta...
  60. Zou Z, Najar F, Wang Y, Roe B, Jiang H. Pyrosequence analysis of expressed sequence tags for Manduca sexta hemolymph proteins involved in immune responses. Insect Biochem Mol Biol. 2008;38:677-82 pubmed publisher
    The tobacco hornworm Manduca sexta is widely used as a model organism to investigate the biochemical basis of insect physiological processes but little transcriptome information is available...
  61. Kim S, Yon F, Gaquerel E, Gulati J, Baldwin I. Tissue specific diurnal rhythms of metabolites and their regulation during herbivore attack in a native tobacco, Nicotiana attenuata. PLoS ONE. 2011;6:e26214 pubmed publisher
    ..The response of metabolites with strong diurnal patterns to simulated attack from the specialist herbivore, Manduca sexta larvae was analyzed and annotated with in-house and public databases...
  62. Suwanchaichinda C, Ochieng R, Zhuang S, Kanost M. Manduca sexta serpin-7, a putative regulator of hemolymph prophenoloxidase activation. Insect Biochem Mol Biol. 2013;43:555-61 pubmed publisher
    ..Six serpins have previously been identified and characterized in the tobacco hornworm Manduca sexta. In this study, we obtained a full-length cDNA sequence of another Manduca serpin, named serpin-7...
  63. Herbert E, Goodrich Blair H. Friend and foe: the two faces of Xenorhabdus nematophila. Nat Rev Microbiol. 2007;5:634-46 pubmed
    ..X. nematophila inhabits and influences the lives of two host animals, helping one to reproduce optimally while killing the other. ..
  64. Woods W, Fusillo S, Trimmer B. Dynamic properties of a locomotory muscle of the tobacco hornworm Manduca sexta during strain cycling and simulated natural crawling. J Exp Biol. 2008;211:873-82 pubmed publisher
    ..The muscle's elastomer-like properties appear to play a major role in its function. ..
  65. Abdullah M, Moussa S, Taylor M, Adang M. Manduca sexta (Lepidoptera: Sphingidae) cadherin fragments function as synergists for Cry1A and Cry1C Bacillus thuringiensis toxins against noctuid moths Helicoverpa zea, Agrotis ipsilon and Spodoptera exigua. Pest Manag Sci. 2009;65:1097-103 pubmed publisher
    ..Recently, it was reported that a small toxin-binding fragment of Manduca sexta (Joh.) cadherin acts as a synergist of Bt toxins to M. sexta, Heliothis virescens F...
  66. Barron Gafford G, Rascher U, Bronstein J, Davidowitz G, Chaszar B, Huxman T. Herbivory of wild Manduca sexta causes fast down-regulation of photosynthetic efficiency in Datura wrightii: an early signaling cascade visualized by chlorophyll fluorescence. Photosynth Res. 2012;113:249-60 pubmed publisher
    ..and longer-term physiological responses in the desert perennial Datura wrightii to herbivory by tobacco hornworm, Manduca sexta...
  67. Nolte A, Funk N, Mukunda L, Gawalek P, Werckenthin A, Hansson B, et al. In situ tip-recordings found no evidence for an Orco-based ionotropic mechanism of pheromone-transduction in Manduca sexta. PLoS ONE. 2013;8:e62648 pubmed publisher
    ..The hawkmoth Manduca sexta is an established model organism for studies of insect olfaction, also due to the availability of the ..
  68. Wilson C, Christensen T, Nighorn A. Inhibition of nitric oxide and soluble guanylyl cyclase signaling affects olfactory neuron activity in the moth, Manduca sexta. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2007;193:715-28 pubmed
    ..In the antennal lobe of the moth, Manduca sexta, nitric oxide is produced in response to odor stimulation, and many interneurons express soluble guanylyl ..
  69. Coate T, Wirz J, Copenhaver P. Reverse signaling via a glycosyl-phosphatidylinositol-linked ephrin prevents midline crossing by migratory neurons during embryonic development in Manduca. J Neurosci. 2008;28:3846-60 pubmed publisher
    ..During the formation of the enteric nervous system (ENS) in the moth Manduca, approximately 300 neurons [enteric plexus (EP) cells] migrate onto the midgut via bilaterally paired muscle ..
  70. Skibbe M, Qu N, Galis I, Baldwin I. Induced plant defenses in the natural environment: Nicotiana attenuata WRKY3 and WRKY6 coordinate responses to herbivory. Plant Cell. 2008;20:1984-2000 pubmed publisher
    ..Differences in responses to single and multiple elicitations indicate an important role of WRKY3 and WRKY6 in potentiating and/or sustaining active JA levels during continuous insect attack. ..
  71. Gaquerel E, Weinhold A, Baldwin I. Molecular interactions between the specialist herbivore Manduca sexta (Lepidoptera, Sphigidae) and its natural host Nicotiana attenuata. VIII. An unbiased GCxGC-ToFMS analysis of the plant's elicited volatile emissions. Plant Physiol. 2009;149:1408-23 pubmed publisher
    Treating wounds in Nicotiana attenuata leaves with Manduca sexta oral secretions (W+OS) mimics most changes elicited by M...
  72. Shroff R, Svatos A. Proton sponge: a novel and versatile MALDI matrix for the analysis of metabolites using mass spectrometry. Anal Chem. 2009;81:7954-9 pubmed publisher
    ..Using this method, the crude regurgitate of the tobacco hornworm caterpillars (Manduca sexta, Lepidoptera, Sphingidae) was analyzed...
  73. Yasukochi Y, Tanaka Okuyama M, Shibata F, Yoshido A, Marec F, Wu C, et al. Extensive conserved synteny of genes between the karyotypes of Manduca sexta and Bombyx mori revealed by BAC-FISH mapping. PLoS ONE. 2009;4:e7465 pubmed publisher
  74. Arenas I, Bravo A, Soberon M, Gomez I. Role of alkaline phosphatase from Manduca sexta in the mechanism of action of Bacillus thuringiensis Cry1Ab toxin. J Biol Chem. 2010;285:12497-503 pubmed publisher
    ..The Cry1A oligomer then interacts with glycosylphosphatidylinositol-anchored receptors. Two Manduca sexta glycosylphosphatidylinositol-anchored proteins, aminopeptidase (APN) and alkaline phosphatase (ALP), have ..
  75. Hares M, Hinchliffe S, Strong P, Eleftherianos I, Dowling A, Ffrench Constant R, et al. The Yersinia pseudotuberculosis and Yersinia pestis toxin complex is active against cultured mammalian cells. Microbiology. 2008;154:3503-17 pubmed publisher
    ..We also demonstrate that oral toxicity of strain IP32953 to Manduca sexta larvae is not due to Tc expression and that lysates of Escherichia coli BL21 expressing the Yersinia Tc ..
  76. Heiling S, Schuman M, Schoettner M, Mukerjee P, Berger B, Schneider B, et al. Jasmonate and ppHsystemin regulate key Malonylation steps in the biosynthesis of 17-Hydroxygeranyllinalool Diterpene Glycosides, an abundant and effective direct defense against herbivores in Nicotiana attenuata. Plant Cell. 2010;22:273-92 pubmed publisher
    ..Larvae of the specialist tobacco hornworm (Manduca sexta) grew up to 10 times as large on ggpps silenced plants, and silenced plants suffered significantly more ..
  77. Allmann S, Halitschke R, Schuurink R, Baldwin I. Oxylipin channelling in Nicotiana attenuata: lipoxygenase 2 supplies substrates for green leaf volatile production. Plant Cell Environ. 2010;33:2028-40 pubmed publisher
    ..These results demonstrate that N. attenuata channels the flux of HPs through the activities of different LOXs, leading to different direct and indirect defence responses mediating the plant's herbivore resistance. ..
  78. Meldau S, Baldwin I, Wu J. SGT1 regulates wounding- and herbivory-induced jasmonic acid accumulation and Nicotiana attenuata's resistance to the specialist lepidopteran herbivore Manduca sexta. New Phytol. 2011;189:1143-56 pubmed publisher
    ..is involved in the induced defense response of a native tobacco (Nicotiana attenuata) to its natural herbivore, Manduca sexta. • We diminished NaSGT1 transcription in N...
  79. Goyret J, Markwell P, Raguso R. The effect of decoupling olfactory and visual stimuli on the foraging behavior of Manduca sexta. J Exp Biol. 2007;210:1398-405 pubmed
    Within an appetitive context, Manduca sexta, a nectivorous nocturnal hawkmoth, can be attracted by a range of stimuli including floral volatiles and visual display, carbon dioxide and water vapor...
  80. Miszner A, Peres A, Castagna M, Bettè S, Giovannardi S, Cherubino F, et al. Structural and functional basis of amino acid specificity in the invertebrate cotransporter KAAT1. J Physiol. 2007;581:899-913 pubmed
    ..of KAAT1, a Na+- and K+-dependent neutral amino acid cotransporter cloned from the larva of the invertebrate Manduca sexta and belonging to the SLC6A gene family has been investigated using electrophysiological and radiotracer ..
  81. Soberon M, Pardo Lopez L, López I, Gomez I, Tabashnik B, Bravo A. Engineering modified Bt toxins to counter insect resistance. Science. 2007;318:1640-2 pubmed
    ..show that susceptibility to the Bt toxin Cry1Ab was reduced by cadherin gene silencing with RNA interference in Manduca sexta, confirming cadherin's role in Bt toxicity...
  82. Hummel G, Schurr U, Baldwin I, Walter A. Herbivore-induced jasmonic acid bursts in leaves of Nicotiana attenuata mediate short-term reductions in root growth. Plant Cell Environ. 2009;32:134-43 pubmed publisher
    Root growth in Nicotiana attenuata is transiently reduced after application of oral secretions (OS) of Manduca sexta larvae to wounds in leaves. Feeding of M...
  83. Coate T, Swanson T, Copenhaver P. Reverse signaling by glycosylphosphatidylinositol-linked Manduca ephrin requires a SRC family kinase to restrict neuronal migration in vivo. J Neurosci. 2009;29:3404-18 pubmed publisher
    ..In the embryonic enteric nervous system (ENS) of the moth Manduca sexta, migratory neurons forming the enteric plexus (EP cells) express a single Ephrin ligand (GPI-linked ..
  84. Glendinning J, Foley C, Loncar I, Rai M. Induced preference for host plant chemicals in the tobacco hornworm: contribution of olfaction and taste. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2009;195:591-601 pubmed publisher
    Many herbivorous insects induce preferences for host plants. Recent work in Manduca sexta indicates that induced preferences are mediated by a "tuning" of the peripheral taste system to chemicals within host plant foliage...
  85. Kessler D, Diezel C, Baldwin I. Changing pollinators as a means of escaping herbivores. Curr Biol. 2010;20:237-42 pubmed publisher
    ..produces flowers that open at night and release benzyl acetone (BA) to attract night-active hawkmoth pollinators (Manduca quinquemaculata and M. sexta), which are both herbivores and pollinators...
  86. Vandock K, Drummond C, Smith S, Fioravanti C. Midgut and fatbody mitochondrial transhydrogenase activities during larval-pupal development of the tobacco hornworm, Manduca sexta. J Insect Physiol. 2010;56:774-9 pubmed publisher
    Midgut and fatbody mitochondria from fifth larval instar Manduca sexta display a membrane-associated transhydrogenase that catalyzes a reversible hydride ion transfer between NADP(H) and NAD(H)...
  87. Diezel C, Allmann S, Baldwin I. Mechanisms of optimal defense patterns in Nicotiana attenuata: flowering attenuates herbivory-elicited ethylene and jasmonate signaling. J Integr Plant Biol. 2011;53:971-83 pubmed publisher
    ..These results are consistent with ODT predictions and suggest that the last steps in floral development control the inducibility of at least three plant hormones, optimizing defense-growth tradeoffs. ..
  88. Truman J, Riddiford L. The morphostatic actions of juvenile hormone. Insect Biochem Mol Biol. 2007;37:761-70 pubmed
    ..morphostatic action does not require ecdysteroids, and has been studied in the formation of imaginal discs in Manduca sexta...
  89. Krannich S, Stengl M. Cyclic nucleotide-activated currents in cultured olfactory receptor neurons of the hawkmoth Manduca sexta. J Neurophysiol. 2008;100:2866-77 pubmed publisher
    ..Here, cyclic nucleotide-activated currents in cultured olfactory receptor neurons of the moth Manduca sexta are described, which share properties with currents through vertebrate cyclic nucleotide-gated channels...
  90. Steppuhn A, Gaquerel E, Baldwin I. The two alpha-dox genes of Nicotiana attenuata: overlapping but distinct functions in development and stress responses. BMC Plant Biol. 2010;10:171 pubmed publisher
    ..alpha-dox1, the expression of alpha-dox2 gene is not induced by wounding or elicitors in the oral secretions of Manduca sexta...
  91. Späthe A, Reinecke A, Olsson S, Kesavan S, Knaden M, Hansson B. Plant species- and status-specific odorant blends guide oviposition choice in the moth Manduca sexta. Chem Senses. 2013;38:147-59 pubmed publisher
    ..Using a series of behavioral, electrophysiological, and chromatographic analyses in the Hawk moth, Manduca sexta, we show that gravid females perform a hierarchical choice among host plants of different species and ..
  92. Goyret J, Markwell P, Raguso R. Context- and scale-dependent effects of floral CO2 on nectar foraging by Manduca sexta. Proc Natl Acad Sci U S A. 2008;105:4565-70 pubmed publisher
    ..Their main hawkmoth pollinator, Manduca sexta, can perceive minute variation (0...
  93. Dacks A, Christensen T, Hildebrand J. Modulation of olfactory information processing in the antennal lobe of Manduca sexta by serotonin. J Neurophysiol. 2008;99:2077-85 pubmed publisher
    ..The role of serotonin (5HT) as a neuromodulator of olfactory information processing in the antennal lobe (AL) of Manduca sexta was examined using multichannel extracellular electrodes to record the responses of ensembles of AL neurons ..
  94. Pandey S, Shahi P, Gase K, Baldwin I. Herbivory-induced changes in the small-RNA transcriptome and phytohormone signaling in Nicotiana attenuata. Proc Natl Acad Sci U S A. 2008;105:4559-64 pubmed publisher
  95. Tobler A, Nijhout H. A switch in the control of growth of the wing imaginal disks of Manduca sexta. PLoS ONE. 2010;5:e10723 pubmed publisher
    ..At the end of larval life feeding stops but the disks continue to grow, so at that time disk growth has become uncoupled from nutrition. We sought to determine at exactly what point in development this uncoupling occurs...
  96. Ragan E, An C, Yang C, Kanost M. Analysis of mutually exclusive alternatively spliced serpin-1 isoforms and identification of serpin-1 proteinase complexes in Manduca sexta hemolymph. J Biol Chem. 2010;285:29642-50 pubmed publisher
    Mutually exclusive alternative splicing produces transcripts for 12 serpin-1 isoforms in Manduca sexta that differ only in the region encoding the carboxyl-terminal 36-40-amino acid residues...
  97. Heinrich M, Baldwin I, Wu J. Two mitogen-activated protein kinase kinases, MKK1 and MEK2, are involved in wounding- and specialist lepidopteran herbivore Manduca sexta-induced responses in Nicotiana attenuata. J Exp Bot. 2011;62:4355-65 pubmed publisher
    ..were treated with wounding or simulated herbivory by applying the oral secretions of the specialist herbivore Manduca sexta to wounds...
  98. George N, Sponberg S, Daniel T. Temperature gradients drive mechanical energy gradients in the flight muscle of Manduca sexta. J Exp Biol. 2012;215:471-9 pubmed publisher
    A temperature gradient throughout the dominant flight muscle (dorsolongitudinal muscle, DLM(1)) of the hawkmoth Manduca sexta, together with temperature-dependent muscle contractile rates, demonstrates that significant spatial variation ..
  99. Bozorov T, Pandey S, Dinh S, Kim S, Heinrich M, Gase K, et al. DICER-like proteins and their role in plant-herbivore interactions in Nicotiana attenuata. J Integr Plant Biol. 2012;54:189-206 pubmed publisher
    ..Watson), a model for the study of plant-herbivore interactions. Silencing DCL1 expression was lethal. Manduca sexta larvae performed significantly better on ir-dcl3 and ir-dcl4 plants, but not on ir-dcl2 plants compared to ..
  100. Heil J, Oland L, Lohr C. Acetylcholine-mediated axon-glia signaling in the developing insect olfactory system. Eur J Neurosci. 2007;26:1227-41 pubmed
    In the olfactory system of the sphinx moth Manduca sexta, migration of neuropil glial cells is triggered by olfactory receptor axons and depends on intraglial Ca(2+) signaling...
  101. Mwilaria E, Ghatak C, Daly K. Disruption of GABAA in the insect antennal lobe generally increases odor detection and discrimination thresholds. Chem Senses. 2008;33:267-81 pubmed publisher
    ..Here we psychophysically characterize the effect of GABA A blockade in the AL of the moth Manduca sexta. We used 2 GABA A antagonists and 3 Pavlovian-based behavioral assays of olfactory function...