tsetse flies

Summary

Summary: Bloodsucking flies of the genus Glossina, found primarily in equatorial Africa. Several species are intermediate hosts of trypanosomes.

Top Publications

  1. Dyer N, Lawton S, Ravel S, Choi K, Lehane M, Robinson A, et al. Molecular phylogenetics of tsetse flies (Diptera: Glossinidae) based on mitochondrial (COI, 16S, ND2) and nuclear ribosomal DNA sequences, with an emphasis on the palpalis group. Mol Phylogenet Evol. 2008;49:227-39 pubmed publisher
    Relationships of 13 species of the genus Glossina (tsetse flies) were inferred from mitochondrial (cytochrome oxidase 1, NADH dehydrogenase 2 and 16S) and nuclear (internal transcribed spacer 1 of rDNA) sequences...
  2. Symula R, Marpuri I, Bjornson R, Okedi L, Beadell J, Alam U, et al. Influence of host phylogeographic patterns and incomplete lineage sorting on within-species genetic variability in Wigglesworthia species, obligate symbionts of tsetse flies. Appl Environ Microbiol. 2011;77:8400-8 pubmed publisher
    ..Thus, understanding the adaptive value of these host-symbiont combinations may afford opportunities to develop vector control methods...
  3. Haenni S, Renggli C, Fragoso C, Oberle M, Roditi I. The procyclin-associated genes of Trypanosoma brucei are not essential for cyclical transmission by tsetse. Mol Biochem Parasitol. 2006;150:144-56 pubmed
    EP and GPEET procyclins are the major surface glycoproteins of Trypanosoma brucei in the midgut of tsetse flies (Glossina spp.)...
  4. Somda J, Kamuanga M, Tollens E. Prospective analysis for community participation in trypanosomosis control in The Gambia. Trop Anim Health Prod. 2006;38:103-11 pubmed
  5. Moore S, Shrestha S, Tomlinson K, Vuong H. Predicting the effect of climate change on African trypanosomiasis: integrating epidemiology with parasite and vector biology. J R Soc Interface. 2012;9:817-30 pubmed publisher
    ..The modelling approach presented here provides a framework for using the climate-sensitive aspects of vector and pathogen biology to predict changes in disease prevalence and risk owing to climate change...
  6. MacLeod E, Maudlin I, Darby A, Welburn S. Antioxidants promote establishment of trypanosome infections in tsetse. Parasitology. 2007;134:827-31 pubmed
    Efficient, cyclical transmission of trypanosomes through tsetse flies is central to maintenance of human sleeping sickness and nagana across sub-Saharan Africa...
  7. De Deken R, Sumbu J, Mpiana S, Mansinsa P, Wat senga F, Lutumba P, et al. Trypanosomiasis in Kinshasa: distribution of the vector, Glossina fuscipes quanzensis, and risk of transmission in the peri-urban area. Med Vet Entomol. 2005;19:353-9 pubmed
    ..b>Tsetse flies were mainly found along some of the major rivers in the rural and peri-urban area of Kinshasa...
  8. Abila P, Slotman M, Parmakelis A, Dion K, Robinson A, Muwanika V, et al. High levels of genetic differentiation between Ugandan Glossina fuscipes fuscipes populations separated by Lake Kyoga. PLoS Negl Trop Dis. 2008;2:e242 pubmed publisher
    ..gambiense. Uganda is exceptional in that it harbors both parasites, which are separated by a narrow 160-km belt. This separation is puzzling considering there are no restrictions on the movement of people and animals across this region...
  9. Beadell J, Hyseni C, Abila P, Azabo R, Enyaru J, Ouma J, et al. Phylogeography and population structure of Glossina fuscipes fuscipes in Uganda: implications for control of tsetse. PLoS Negl Trop Dis. 2010;4:e636 pubmed publisher
    ..Population genetics can help to resolve this issue by characterizing the extent of linkage among apparently isolated groups of tsetse...

More Information

Publications62

  1. Savage A, Cerqueira G, Regmi S, Wu Y, El Sayed N, Aksoy S. Transcript expression analysis of putative Trypanosoma brucei GPI-anchored surface proteins during development in the tsetse and mammalian hosts. PLoS Negl Trop Dis. 2012;6:e1708 pubmed publisher
    ..brucei surface proteins during the complete developmental cycle. This knowledge may form the foundation for the development of future novel transmission blocking strategies against metacyclic parasites...
  2. Shaw A, Torr S, Waiswa C, Cecchi G, Wint G, Mattioli R, et al. Estimating the costs of tsetse control options: an example for Uganda. Prev Vet Med. 2013;110:290-303 pubmed publisher
    ..Results indicate that continuous control activities can be cost-effective in reducing tsetse populations, especially where the creation of fly-free zones is challenging and reinvasion pressure high...
  3. Aksoy S, Caccone A, Galvani A, Okedi L. Glossina fuscipes populations provide insights for human African trypanosomiasis transmission in Uganda. Trends Parasitol. 2013;29:394-406 pubmed publisher
    ..We discuss the implications of these findings for large-scale tsetse control programs, including suppression or eradication, being undertaken in Uganda, and potential future genetic applications. ..
  4. Maudlin I. African trypanosomiasis. Ann Trop Med Parasitol. 2006;100:679-701 pubmed
    ..After more than 100 years of effort, trypanosomiasis control remains a controversial topic, subject to the tides of fashion and politics...
  5. G├╝ther M, Lee S, Tetley L, Acosta Serrano A, Ferguson M. GPI-anchored proteins and free GPI glycolipids of procyclic form Trypanosoma brucei are nonessential for growth, are required for colonization of the tsetse fly, and are not the only components of the surface coat. Mol Biol Cell. 2006;17:5265-74 pubmed
    ..While characterizing GlcNAc-PI that accumulates in the TbGPI12 mutant, we observed inositolphosphoceramides for the first time in this organism...
  6. Runyen Janecky L, Brown A, Ott B, Tujuba H, Rio R. Regulation of high-affinity iron acquisition homologues in the tsetse fly symbiont Sodalis glossinidius. J Bacteriol. 2010;192:3780-7 pubmed publisher
    ..In vivo expression analysis showed that hemT and sitA are expressed when Sodalis is within tsetse fly hosts, suggesting a biological role for these genes when Sodalis is within the tsetse fly...
  7. Bouyer J, Guerrini L, Desquesnes M, de La Rocque S, Cuisance D. Mapping African Animal Trypanosomosis risk from the sky. Vet Res. 2006;37:633-45 pubmed
    ..The attempt of the present work was to assess the abundance of tsetse flies and AAT risk using remote sensing coupled to field environmental data, along a Mouhoun river section of 234 km ..
  8. Akoda K, van den Bossche P, Marcotty T, Kubi C, Coosemans M, De Deken R, et al. Nutritional stress affects the tsetse fly's immune gene expression. Med Vet Entomol. 2009;23:195-201 pubmed publisher
    ..The majority of tsetse flies (Glossina spp...
  9. Solano P, Ravel S, Bouyer J, Camara M, Kagbadouno M, Dyer N, et al. The population structure of Glossina palpalis gambiensis from island and continental locations in Coastal Guinea. PLoS Negl Trop Dis. 2009;3:e392 pubmed publisher
    ..These data are discussed with respect to the feasibility and sustainability of control strategies in those sites currently experiencing, or at risk of, sleeping sickness...
  10. Schneider D, Garschall K, Parker A, Abd Alla A, Miller W. Global Wolbachia prevalence, titer fluctuations and their potential of causing cytoplasmic incompatibilities in tsetse flies and hybrids of Glossina morsitans subgroup species. J Invertebr Pathol. 2013;112 Suppl:S104-15 pubmed publisher
    ..VNTR-based (Variable-Number-Tandem-Repeat) molecular screening tool for fingerprinting Wolbachia-infections in tsetse flies. The VNTR-141 locus provides reliable and concise differentiation between Wolbachia strains deriving from ..
  11. Attardo G, Benoit J, Michalková V, Yang G, Roller L, Bohova J, et al. Analysis of lipolysis underlying lactation in the tsetse fly, Glossina morsitans. Insect Biochem Mol Biol. 2012;42:360-70 pubmed
    Female tsetse flies undergo viviparous reproduction, generating one larva each gonotrophic cycle. Larval nourishment is provided by the mother in the form of milk secretions...
  12. Lindh J, Goswami P, Blackburn R, Arnold S, Vale G, Lehane M, et al. Optimizing the colour and fabric of targets for the control of the tsetse fly Glossina fuscipes fuscipes. PLoS Negl Trop Dis. 2012;6:e1661 pubmed publisher
    ..To provide a rational basis for cost-effective designs of target, we undertook studies to identify the optimal target colour...
  13. Haines L, Lehane S, Pearson T, Lehane M. Tsetse EP protein protects the fly midgut from trypanosome establishment. PLoS Pathog. 2010;6:e1000793 pubmed publisher
    ..As starvation is a common field event, this fact may be of considerable importance in the epidemiology of African trypanosomiasis...
  14. Adams E, Hamilton P, Rodrigues A, Malele I, Delespaux V, Teixeira M, et al. New Trypanosoma (Duttonella) vivax genotypes from tsetse flies in East Africa. Parasitology. 2010;137:641-50 pubmed publisher
    ..Investigation of mammalian host range and pathogenicity will reveal the importance of these new trypanosomes for the epidemiology and control of animal trypanosomiasis in East Africa...
  15. Geiger A, Fardeau M, Njiokou F, Ollivier B. Glossina spp. gut bacterial flora and their putative role in fly-hosted trypanosome development. Front Cell Infect Microbiol. 2013;3:34 pubmed publisher
    ..In fact, in addition to the three bacterial symbionts that have previously been characterized, tsetse flies may harbor additional bacterial inhabitants...
  16. Krafsur E. Tsetse flies: genetics, evolution, and role as vectors. Infect Genet Evol. 2009;9:124-41 pubmed publisher
    b>Tsetse flies (Diptera: Glossinidae) are an ancient taxon of one genus, Glossina, and limited species diversity. All are exclusively haematophagous and confined to sub-Saharan Africa...
  17. Aksoy S, Weiss B, Attardo G. Paratransgenesis applied for control of tsetse transmitted sleeping sickness. Adv Exp Med Biol. 2008;627:35-48 pubmed publisher
  18. Vaughan S. Assembly of the flagellum and its role in cell morphogenesis in Trypanosoma brucei. Curr Opin Microbiol. 2010;13:453-8 pubmed publisher
    ..In this review we discuss evidence published in the past four years that is unravelling the role of the flagellum in organelle segregation, inheritance of cell shape and cytokinesis...
  19. Torr S, Mangwiro T, Hall D. Shoo fly, don't bother me! Efficacy of traditional methods of protecting cattle from tsetse. Med Vet Entomol. 2011;25:192-201 pubmed publisher
    ..The practical benefits and difficulties of using repellents and/or housing to manage trypanosomiases are discussed...
  20. Simo G, Njiokou F, Mbida Mbida J, Njitchouang G, Herder S, Asonganyi T, et al. Tsetse fly host preference from sleeping sickness foci in Cameroon: epidemiological implications. Infect Genet Evol. 2008;8:34-9 pubmed
    ..For the whole study, 4929 tsetse flies were caught: 3933 (79.8%) Glossina palpalis palpalis, 626 (12.7%) Glossina pallicera pallicera, 276 (5...
  21. Laveissiere C, Camara M, Rayaisse J, Salou E, KagbaDouno M, Solano P. Trapping tsetse flies on water. Parasite. 2011;18:141-4 pubmed
    Riverine tsetse flies such as Glossina palpalis gambiensis and G. tachinoides are the vectors of human and animal trypanosomoses in West Africa...
  22. Adams E, Hamilton P, Gibson W. African trypanosomes: celebrating diversity. Trends Parasitol. 2010;26:324-8 pubmed publisher
    ..We should first acknowledge that these novel trypanosomes exist and then take steps to investigate their host range, pathogenicity to livestock and response to chemotherapy...
  23. Solano P, Ravel S, de Meeus T. How can tsetse population genetics contribute to African trypanosomiasis control?. Trends Parasitol. 2010;26:255-63 pubmed publisher
    ..Implications of these studies for large-scale tsetse control programmes being undertaken in West Africa are important, particularly regarding control strategies (suppression or eradication)...
  24. Bouyer J, Stachurski F, Kabore I, Bauer B, Lancelot R. Tsetse control in cattle from pyrethroid footbaths. Prev Vet Med. 2007;78:223-38 pubmed
    ..technique on the one hand on released cohorts of reared, irradiated flies, and on the other hand on wild tsetse flies. In both cases, the footbath treatment was associated with a reduction of the apparent fly density probably ..
  25. Pais R, Lohs C, Wu Y, Wang J, Aksoy S. The obligate mutualist Wigglesworthia glossinidia influences reproduction, digestion, and immunity processes of its host, the tsetse fly. Appl Environ Microbiol. 2008;74:5965-74 pubmed publisher
    b>Tsetse flies (Diptera: Glossinidae) are vectors for trypanosome parasites, the agents of the deadly sleeping sickness disease in Africa...
  26. Grace D, Randolph T, Affognon H, Dramane D, Diall O, Clausen P. Characterisation and validation of farmers' knowledge and practice of cattle trypanosomosis management in the cotton zone of West Africa. Acta Trop. 2009;111:137-43 pubmed publisher
    ..Most farmers (96%) recognised the common signs of trypanosomosis, 70% knew the role of tsetse flies in transmitting the disease and 96% had knowledge of drugs used for treatment...
  27. Soumana I, Simo G, Njiokou F, Tchicaya B, Abd Alla A, Cuny G, et al. The bacterial flora of tsetse fly midgut and its effect on trypanosome transmission. J Invertebr Pathol. 2013;112 Suppl:S89-93 pubmed publisher
    ..The data delineated in these studies under score the need to carry out detailed investigations on the role of resident bacteria on the physiology of the fly and vector competence...
  28. Kubi C, van den Abbeele J, De Deken R, Marcotty T, Dorny P, van den Bossche P. The effect of starvation on the susceptibility of teneral and non-teneral tsetse flies to trypanosome infection. Med Vet Entomol. 2006;20:388-92 pubmed
    ..In tsetse flies, newly emerged or teneral flies are considered the most likely to develop a mature, infective trypanosome ..
  29. Kubi C, Billiouw M, van den Bossche P. Age prevalence of trypanosomal infections in female Glossina morsitans morsitans (Diptera: Glossinidae) on the plateau area of eastern Zambia. Onderstepoort J Vet Res. 2007;74:223-9 pubmed
    ..Observations strongly suggest that tsetse acquire new midgut infections at any age and that maturation of these infections is not limited to those obtained during the first blood meal...
  30. Mutika G, Marin C, Parker A, Boucias D, Vreysen M, Abd Alla A. Impact of salivary gland hypertrophy virus infection on the mating success of male Glossina pallidipes: consequences for the sterile insect technique. PLoS ONE. 2012;7:e42188 pubmed publisher
    Many species of tsetse flies are infected by a virus (GpSGHV) that causes salivary gland hypertrophy (SGH). Female Glossina pallidipes (Austen) with SGH symptoms (SGH+) have reduced fecundity and SGH+ male G...
  31. Caljon G, Van den Abbeele J, Sternberg J, Coosemans M, De Baetselier P, Magez S. Tsetse fly saliva biases the immune response to Th2 and induces anti-vector antibodies that are a useful tool for exposure assessment. Int J Parasitol. 2006;36:1025-35 pubmed
    b>Tsetse flies (Glossina sp.) are blood-feeding dipteran insects that transmit African trypanosomes, parasites that are responsible for human sleeping sickness and veterinary infections...
  32. Kagbadouno M, Camara M, Bouyer J, Courtin F, Onikoyamou M, Schofield C, et al. Progress towards the eradication of Tsetse from the Loos islands, Guinea. Parasit Vectors. 2011;4:18 pubmed publisher
    ..After baseline data collection, tsetse control began on the islands in 2006. On each of the three islands a specific combination of control methods was implemented according to the entomological situation found...
  33. Holzmuller P, Grebaut P, Cuny G, Biron D. Tsetse flies, trypanosomes, humans and animals: what is proteomics revealing about their crosstalks?. Expert Rev Proteomics. 2010;7:113-26 pubmed publisher
  34. Urwyler S, Vassella E, Van den Abbeele J, Renggli C, Blundell P, Barry J, et al. Expression of procyclin mRNAs during cyclical transmission of Trypanosoma brucei. PLoS Pathog. 2005;1:e22 pubmed
    ..The finding that this life cycle stage is usually negative for procyclin as well is new, and means that the paradigm will need to be revised...
  35. Wang J, Wu Y, Yang G, Aksoy S. Interactions between mutualist Wigglesworthia and tsetse peptidoglycan recognition protein (PGRP-LB) influence trypanosome transmission. Proc Natl Acad Sci U S A. 2009;106:12133-8 pubmed publisher
    b>Tsetse flies, the sole vectors of African trypanosomes, have coevolved with mutualistic endosymbiont Wigglesworthia glossinidiae...
  36. Geiger A, Fardeau M, Grebaut P, Vatunga G, Josenando T, Herder S, et al. First isolation of Enterobacter, Enterococcus, and Acinetobacter spp. as inhabitants of the tsetse fly (Glossina palpalis palpalis) midgut. Infect Genet Evol. 2009;9:1364-70 pubmed publisher
    ..was the most frequently isolated. The role of these bacteria in the gut, in terms of vector competence of the tsetse fly, is discussed, as is the possibility of using these bacteria to produce in situ trypanolytic molecules...
  37. Abd Alla A, Bossin H, Cousserans F, Parker A, Bergoin M, Robinson A. Development of a non-destructive PCR method for detection of the salivary gland hypertrophy virus (SGHV) in tsetse flies. J Virol Methods. 2007;139:143-9 pubmed
    A PCR based diagnostic method to detect salivary gland hypertrophy virus (SGHV) in tsetse flies is described. Two sets of primers GpSGHV1F/GpSGHV1R and GpSGHV2F/GpSGHV2R were selected from a virus-specific sequence...
  38. Wamwiri F, Nkwengulila G, Clausen P. Hosts of Glossina fuscipes fuscipes and G. pallidipes in areas of western Kenya with endemic sleeping sickness, as determined using an egg-yolk (IgY) ELISA. Ann Trop Med Parasitol. 2007;101:225-32 pubmed
    ..In Busia at least, the use of animals, especially cattle, covered in insecticide would probably be an effective method of controlling the tsetse vectors of the trypanosomes that cause human and 'animal' trypanosomiases...
  39. Tesfaye D, Speybroeck N, De Deken R, Thys E. Economic burden of bovine trypanosomosis in three villages of Metekel zone, northwest Ethiopia. Trop Anim Health Prod. 2012;44:873-9 pubmed publisher
    ..Thus, tsetse suppression activities that involve the local community can be an important tool towards minimizing the economic burden of the disease in the area...
  40. Abd Alla A, Parker A, Vreysen M, Bergoin M. Tsetse salivary gland hypertrophy virus: hope or hindrance for tsetse control?. PLoS Negl Trop Dis. 2011;5:e1220 pubmed publisher
    MANY SPECIES OF TSETSE FLIES (DIPTERA: Glossinidae) are infected with a virus that causes salivary gland hypertrophy (SGH), and flies with SGH symptoms have a reduced fecundity and fertility...
  41. Terblanche J, Chown S. Effects of flow rate and temperature on cyclic gas exchange in tsetse flies (Diptera, Glossinidae). J Insect Physiol. 2010;56:513-21 pubmed publisher
    ..This is unusual among insects showing CGE or DGE patterns because increases in metabolic rate are usually modulated by increases in frequency, but either no change or a decline in burst volume...
  42. Wang J, Aksoy S. PGRP-LB is a maternally transmitted immune milk protein that influences symbiosis and parasitism in tsetse's offspring. Proc Natl Acad Sci U S A. 2012;109:10552-7 pubmed publisher
    ..Thus, PGRP-LB plays a pivotal role in tsetse's fitness by protecting symbiosis against host-inflicted damage during development and by controlling parasite infections in adults that can otherwise reduce host fecundity...
  43. Sciarretta A, Tikubet G, Baumgartner J, Girma M, Trematerra P. Spatial clustering and associations of two savannah tsetse species, Glossina morsitans submorsitans and Glossina pallidipes (Diptera: Glossinidae), for guiding interventions in an adaptive cattle health management framework. Bull Entomol Res. 2010;100:661-70 pubmed publisher
  44. Kolev N, Ramey Butler K, Cross G, Ullu E, Tschudi C. Developmental progression to infectivity in Trypanosoma brucei triggered by an RNA-binding protein. Science. 2012;338:1352-3 pubmed publisher
    ..Thus, events leading to acquisition of infectivity in the insect vector are now accessible to laboratory investigation, providing an opening for new intervention strategies...
  45. Vale G, Hall D, Chamisa A, Torr S. Towards an early warning system for Rhodesian sleeping sickness in savannah areas: man-like traps for tsetse flies. PLoS Negl Trop Dis. 2012;6:e1978 pubmed publisher
    In the savannahs of East and Southern Africa, tsetse flies (Glossina spp.) transmit Trypanosoma brucei rhodesiense which causes Rhodesian sleeping sickness, the zoonotic form of human African trypanosomiasis...
  46. Bouyer J, Balenghien T, Ravel S, Vial L, Sidibe I, Thevenon S, et al. Population sizes and dispersal pattern of tsetse flies: rolling on the river?. Mol Ecol. 2009;18:2787-97 pubmed publisher
    ..In these fragmented landscapes, tsetse flies displayed localized, small subpopulations with relatively short effective dispersal...
  47. Ouma J, Marquez J, Krafsur E. Microgeographical breeding structure of the tsetse fly, Glossina pallidipes in south-western Kenya. Med Vet Entomol. 2006;20:138-49 pubmed
    ..Harmonic mean effective (= breeding) population sizes were 180 in Lambwe and 551 in Nguruman. The genetic data suggest that G. pallidipes in Lambwe and Nguruman have been endemic for long intervals...
  48. Konnai S, Mekata H, Odbileg R, Simuunza M, Chembensof M, Witola W, et al. Detection of Trypanosoma brucei in field-captured tsetse flies and identification of host species fed on by the infected flies. Vector Borne Zoonotic Dis. 2008;8:565-73 pubmed publisher
    The prevalence of trypanosome infections in tsetse flies in the Chiawa area of Lower Zambezi in Zambia, with endemic trypanosomosis, was determined by a polymerase chain reaction (PCR) method that allowed the detection of trypanosome DNA ..
  49. Novakova E, Hypsa V. A new Sodalis lineage from bloodsucking fly Craterina melbae (Diptera, Hippoboscoidea) originated independently of the tsetse flies symbiont Sodalis glossinidius. FEMS Microbiol Lett. 2007;269:131-5 pubmed
    Symbiotic bacterium closely related to the secondary symbiont of tsetse flies, Sodalis glossinidius, has been described from the bloodsucking fly Craterina melbae...
  50. Akoda K, Harouna S, Marcotty T, De Deken R, van den Bossche P. Investigations on the transmissibility of Trypanosoma congolense by the tsetse fly Glossina morsitans morsitans during its development in a mammalian host. Acta Trop. 2008;107:17-9 pubmed publisher
    ..Batches of 160 male teneral tsetse flies were given a single bloodmeal on mice infected with this T...
  51. Vassella E, Oberle M, Urwyler S, Renggli C, Studer E, Hemphill A, et al. Major surface glycoproteins of insect forms of Trypanosoma brucei are not essential for cyclical transmission by tsetse. PLoS ONE. 2009;4:e4493 pubmed publisher
    Procyclic forms of Trypanosoma brucei reside in the midgut of tsetse flies where they are covered by several million copies of glycosylphosphatidylinositol-anchored proteins known as procyclins...
  52. Tchouomene Labou J, Nana Djeunga H, Simo G, Njitchouang G, Cuny G, Asonganyi T, et al. Spatial and temporal variations relevant to tsetse control in the Bipindi focus of southern Cameroon. Parasit Vectors. 2013;6:193 pubmed publisher
    ..It was shown that perennial water sources maintain a favourable biotope for tsetse flies and thus the transmission dynamics of sleeping sickness...
  53. Simarro P, Cecchi G, Paone M, Franco J, Diarra A, Ruiz J, et al. The Atlas of human African trypanosomiasis: a contribution to global mapping of neglected tropical diseases. Int J Health Geogr. 2010;9:57 pubmed publisher
    ..For this reason WHO launched the HAT Atlas initiative, jointly implemented with the Food and Agriculture Organization of the United Nations, in the framework of the Programme Against African Trypanosomosis...