fireflies

Summary

Summary: The family Lampyidae, which are bioluminescent BEETLES. They contain FIREFLY LUCIFERIN and LUCIFERASES. Oxidation of firefly luciferin results in luminescence.

Top Publications

  1. South A, Sota T, Abe N, Yuma M, Lewis S. The production and transfer of spermatophores in three Asian species of Luciola fireflies. J Insect Physiol. 2008;54:861-6 pubmed publisher
    ..While spermatophores have been documented in some North American fireflies (Coleoptera: Lampyridae), little is known concerning either production or transfer of spermatophores in the ..
  2. Lee K, Kang N, Rogozin E, Kim H, Cho Y, Bode A, et al. Myricetin is a novel natural inhibitor of neoplastic cell transformation and MEK1. Carcinogenesis. 2007;28:1918-27 pubmed
    ..Overall, these results indicated that myricetin has potent anticancer-promoting activity and mainly targets MEK signaling, which may contribute to the chemopreventive potential of several foods including red wines...
  3. Kato H, Nakatsu T. [Enigma of firefly glowing]. Seikagaku. 2007;79:697-701 pubmed
  4. Lewis S, Cratsley C. Flash signal evolution, mate choice, and predation in fireflies. Annu Rev Entomol. 2008;53:293-321 pubmed
    ..We present a comprehensive overview of sexual selection in lampyrids, including evidence from Photinus fireflies that females choose their mates on the basis of male flash signals, and discuss the importance of examining both ..
  5. Auld D, Southall N, Jadhav A, Johnson R, Diller D, Simeonov A, et al. Characterization of chemical libraries for luciferase inhibitory activity. J Med Chem. 2008;51:2372-86 pubmed publisher
    ..pyralis luciferase. We describe the structure-activity relationship of the luciferase inhibitors and discuss the use of this data in the interpretation of HTS results and configuration of luciferase-based assays...
  6. Ohtsuki H, Yokoyama J, Ohba N, Ohmiya Y, Kawata M. Nitric oxide synthase (NOS) in the Japanese fireflies Luciola lateralis and Luciola cruciata. Arch Insect Biochem Physiol. 2008;69:176-88 pubmed publisher
    ..is one of the key enzymes controlling flash patterns, we determined the cDNA sequences of NOS in the Japanese fireflies Luciola lateralis and L. cruciata. The identity of the NOS sequences was very high between these 2 species...
  7. Hosseinkhani S. Molecular enigma of multicolor bioluminescence of firefly luciferase. Cell Mol Life Sci. 2011;68:1167-82 pubmed publisher
  8. Goh K, Li C. A photocytes-associated fatty acid-binding protein from the light organ of adult Taiwanese firefly, Luciola cerata. PLoS ONE. 2011;6:e29576 pubmed publisher
    ..In this study, we determined the structural and functional characteristics of a novel FABP (lcFABP) from the light organ of adult Taiwanese firefly, Luciola cerata, and showed anatomical association of lcFABP with photocytes...
  9. Wang Y, Kubota H, Yamada N, Irie T, Akiyama H. Quantum yields and quantitative spectra of firefly bioluminescence with various bivalent metal ions. Photochem Photobiol. 2011;87:846-52 pubmed publisher
    ..We also found that having more metal ions accelerated bioluminescence reactions. The sensitivity of the reaction rate had no correlation with those of the quantum yield and spectrum...

More Information

Publications62

  1. Stanger Hall K, Lloyd J, Hillis D. Phylogeny of North American fireflies (Coleoptera: Lampyridae): implications for the evolution of light signals. Mol Phylogenet Evol. 2007;45:33-49 pubmed
    Representatives of the beetle family Lampyridae ("fireflies", "lightningbugs") are well known for their use of light signals for species recognition during mate search...
  2. Demary K, Lewis S. Male courtship attractiveness and paternity success in Photinus greeni fireflies. Evolution. 2007;61:431-9 pubmed
    ..In Photinus fireflies, females preferentially respond to males based on their bioluminescent courtship signals, and females gain ..
  3. Cai D, Marques M, Nogueira F. Accurate color tuning of firefly chromophore by modulation of local polarization electrostatic fields. J Phys Chem B. 2011;115:329-32 pubmed publisher
    ..This method provides a predictable determination of the structural modifications leading to a particular color shift and/or fluorescent efficiency enhancement...
  4. Suzuki C, Nakajima Y, Akimoto H, Wu C, Ohmiya Y. A new additional reporter enzyme, dinoflagellate luciferase, for monitoring of gene expression in mammalian cells. Gene. 2005;344:61-6 pubmed
    ..Thus, the triple-reporter assay can identify three transcriptional activities of different genes at the same time. This work establishes the DL gene as a new efficient marker of gene expression in mammalian cells...
  5. Ribeiro C, Esteves da Silva J. Kinetics of inhibition of firefly luciferase by oxyluciferin and dehydroluciferyl-adenylate. Photochem Photobiol Sci. 2008;7:1085-90 pubmed publisher
    ..7+/-0.7 and 14.9+/-0.2 microM, respectively. L-AMP is a stronger inhibitor of Luc than oxyluciferin and the major responsible for the characteristic flash profile of in vitro Luc bioluminescence...
  6. Nakatsu T, Ichiyama S, Hiratake J, Saldanha A, Kobashi N, Sakata K, et al. Structural basis for the spectral difference in luciferase bioluminescence. Nature. 2006;440:372-6 pubmed
    b>Fireflies communicate with each other by emitting yellow-green to yellow-orange brilliant light...
  7. Niwa K, Ichino Y, Kumata S, Nakajima Y, Hiraishi Y, Kato D, et al. Quantum yields and kinetics of the firefly bioluminescence reaction of beetle luciferases. Photochem Photobiol. 2010;86:1046-9 pubmed publisher
    ..61). Mutant analyses of active site-substituted Pyrocoelia miyako luciferases showed that, although k(cat) was decreased by the mutations, the QY was not significantly affected...
  8. Auld D, Zhang Y, Southall N, Rai G, Landsman M, MacLure J, et al. A basis for reduced chemical library inhibition of firefly luciferase obtained from directed evolution. J Med Chem. 2009;52:1450-8 pubmed publisher
    ..This study demonstrates the power of large-scale quantitative analysis of structure-activity relationships (>100K compounds) in addressing important questions such as a target's druggability. ..
  9. Nakatani N, Hasegawa J, Nakatsuji H. Red light in chemiluminescence and yellow-green light in bioluminescence: color-tuning mechanism of firefly, Photinus pyralis, studied by the symmetry-adapted cluster-configuration interaction method. J Am Chem Soc. 2007;129:8756-65 pubmed
    ..Further analyses were performed to verify the spectral-tuning mechanism based on the protonation state and the resonance structure of oxyluciferin...
  10. Leitão J, Esteves da Silva J. Firefly luciferase inhibition. J Photochem Photobiol B. 2010;101:1-8 pubmed publisher
    ..This review summarizes the main inhibitors of Luc and the corresponding inhibition kinetic parameters...
  11. Fahmi N, Dedkova L, Wang B, Golovine S, Hecht S. Site-specific incorporation of glycosylated serine and tyrosine derivatives into proteins. J Am Chem Soc. 2007;129:3586-97 pubmed
    ..For mutants containing glycosylated tyrosines, the red shift was observed only when the carbohydrate moiety was fully deacetylated...
  12. Oba Y, Yoshida M, Shintani T, Furuhashi M, Inouye S. Firefly luciferase genes from the subfamilies Psilocladinae and Ototretinae (Lampyridae, Coleoptera). Comp Biochem Physiol B Biochem Mol Biol. 2012;161:110-6 pubmed publisher
    ..the three firefly luciferases (?max, 545-546nm) were shorter than those by known luciferases from the nocturnal fireflies (?max, 550-568nm)...
  13. Xu G, Liu Y. Plant ERD2s self-interact and interact with GTPase-activating proteins and ADP-ribosylation factor 1. Plant Signal Behav. 2012;7:1092-4 pubmed publisher
    ..We also analyze the characteristics of ERD2s within a species and among different species...
  14. Hagihara S, Lin W, Kusano S, Chao X, Hori T, Imoto S, et al. The Crosslink formation of 2'-OMe oligonucleotide containing 2-amino-6-vinylpurine protects mRNA from miRNA-mediated silencing. Chembiochem. 2013;14:1427-9 pubmed publisher
    ..This method can interfere with specific miRNA-mRNA interactions by recognizing sequences unique to the 3'-UTR that are inherent in each mRNA. ..
  15. Rabha M, Sharma U, Goswami A, Gohain Barua A. Bioluminescence emissions of female fireflies of the species Luciola praeusta. J Photochem Photobiol B. 2017;170:134-139 pubmed publisher
    Numerous investigations have been carried out on bioluminescence emissions from male fireflies. However, very few observations have been made on the emitted light from female specimens...
  16. Davidsson R, Boketoft A, Bristulf J, Kotarsky K, Olde B, Owman C, et al. Developments toward a microfluidic system for long-term monitoring of dynamic cellular events in immobilized human cells. Anal Chem. 2004;76:4715-20 pubmed
    ..The developed system and data outcome was compared with a corresponding microtiter plate performed with the same cell line to highlight the advantages obtained in the microfluidic format...
  17. Lai C, Chen C, Au L. Comparison between the repression potency of siRNA targeting the coding region and the 3'-untranslated region of mRNA. Biomed Res Int. 2013;2013:637850 pubmed publisher
    ..The siRNA elicited higher repression in the coding region when the target configuration was stable, and needed to be solved by translation. A siRNA may otherwise favor the target at 3'-UTR. ..
  18. Sobhani Damavandifar Z, Hosseinkhani S, Sajedi R. Proposed ionic bond between Arg300 and Glu270 and Glu271 are not involved in inactivation of a mutant firefly luciferase (LRR). Enzyme Microb Technol. 2016;86:17-24 pubmed publisher
  19. Novak M. Redescription of immature stages of central European fireflies, Part 1: <i>Lampyris</i> <i>noctiluca</i> (Linnaeus, 1758) larva, pupa and notes on its biology (Coleoptera: Lampyridae: Lampyrinae). Zootaxa. 2017;4247:429-444 pubmed publisher
    ..Male and female pupae are briefly described, including notes on behaviour as well as light production of the immature stages. Observed structures, life cycle and behaviour of larvae and pupae are discussed. ..
  20. Pinto da Silva L, Esteves da Silva J. Computational investigation of the effect of pH on the color of firefly bioluminescence by DFT. Chemphyschem. 2011;12:951-60 pubmed publisher
    ..These interactions can suffer also from rearrangement due to entry of external solvent and changes in the protonation state of some amino acid residues and adenosine monophosphate (AMP)...
  21. Rasouli S, Hosseinkhani S, Yaghmaei P, Ebrahim Habibi A. Effects of sucrose and trehalose on stability, kinetic properties, and thermal aggregation of firefly luciferase. Appl Biochem Biotechnol. 2011;165:572-82 pubmed publisher
    ..Minor changes in content of secondary structure of firefly luciferase are observed upon treatment with additives...
  22. Schweizer R, Aponte R, Zimmermann S, Weber A, Reinstein J. Fine tuning of a biological machine: DnaK gains improved chaperone activity by altered allosteric communication and substrate binding. Chembiochem. 2011;12:1559-73 pubmed publisher
    ..As the underlying mechanistic reason for this change we propose an altered interface of allosteric communication of mutant G384A, which is notably located at a hinge position between nucleotide and substrate binding domain...
  23. Nakhi A, Rahman M, Kishore R, Meda C, Deora G, Parsa K, et al. Pyrrolo[2,3-b]quinoxalines as inhibitors of firefly luciferase: their Cu-mediated synthesis and evaluation as false positives in a reporter gene assay. Bioorg Med Chem Lett. 2012;22:6433-41 pubmed publisher
    ..The key observations disclosed here can alert users of luciferase reporter gene assays for possible false positive results due to the direct inhibition of luciferase...
  24. Yi Y, Sun X, Qin J, Zhao Q, Liao W, Long Y. Experimental identification of microRNA targets on the 3' untranslated region of human FMR1 gene. J Neurosci Methods. 2010;190:34-8 pubmed publisher
    ..The constructs used in this study can be widely used to identify the miRNA targets in any interested genes, which will greatly promote the current progress in understanding the biological function of miRNAs...
  25. Ghazawi I, Cutler S, Low P, Mellick A, Ralph S. Inhibitory effects associated with use of modified Photinus pyralis and Renilla reniformis luciferase vectors in dual reporter assays and implications for analysis of ISGs. J Interferon Cytokine Res. 2005;25:92-102 pubmed
    ..Thus, it is important to be aware of these complications when using luciferase reporter systems in general or for analyzing cytokine-mediated responsive regulation of target genes, particularly by the type I IFNs...
  26. Bocakova M, Bocak L, Gimmel M, Friedlova T. A review of the genus Lamellipalpodes Maulik (Coleoptera: Lampyridae). Zootaxa. 2015;3925:409-21 pubmed publisher
    ..nov. from China (Yunnan) and northern Laos. Six species are redescribed. Illustrations of diagnostic characters are included, with a checklist and a key to Lamellipalpodes species. The genus is newly recorded from China and Laos. ..
  27. Kaneko M, Cahill G. Light-dependent development of circadian gene expression in transgenic zebrafish. PLoS Biol. 2005;3:e34 pubmed
    ..In summary, per3-luc zebrafish has revealed complex interactions among developmental events, light, and temperature in the expression of a clock gene...
  28. Vishwanath R, Brown C, Wagner J, Meechoovet H, Naranjo A, Wright C, et al. A quantitative high-throughput chemotaxis assay using bioluminescent reporter cells. J Immunol Methods. 2005;302:78-89 pubmed
  29. Muraji M, Arakaki N, Tanizaki S. Evolutionary relationship between two firefly species, Curtos costipennis and C. okinawanus (Coleoptera, Lampyridae), in the Ryukyu Islands of Japan revealed by the mitochondrial and nuclear DNA sequences. ScientificWorldJournal. 2012;2012:653013 pubmed publisher
    ..0-1.4 million years ago, suggesting the influence of submergence and subdivision of a paleopeninsula extending between the Ryukyu Islands and continental China through Taiwan in the early Pleistocene...
  30. Santhi V, Mustafa A. Assessment of organochlorine pesticides and plasticisers in the Selangor River basin and possible pollution sources. Environ Monit Assess. 2013;185:1541-54 pubmed publisher
  31. Shavkunov A, Panova N, Prasai A, Veselenak R, Bourne N, Stoilova McPhie S, et al. Bioluminescence methodology for the detection of protein-protein interactions within the voltage-gated sodium channel macromolecular complex. Assay Drug Dev Technol. 2012;10:148-60 pubmed publisher
    ..We envision the methodology presented here as a new valuable tool to allow functional evaluations of protein-channel complexes toward probe development and drug discovery targeting ion channels implicated in human disorders...
  32. Branchini B, Ablamsky D, Murtiashaw M, Uzasci L, Fraga H, Southworth T. Thermostable red and green light-producing firefly luciferase mutants for bioluminescent reporter applications. Anal Biochem. 2007;361:253-62 pubmed
    ..The results presented here provide evidence that it is feasible to monitor two distinct activities at 37 degrees C with these novel thermostable proteins...
  33. Frantová D, Moravec F. Comparative studies on intestine ultrastructure of third-stage larvae and adults of Cystidicoloides ephemeridarum (Nematoda, Cystidicolidae). Parasitol Res. 2004;94:377-83 pubmed
    ..In the adults, a minor portion of glycogen, together with lipid droplets, has been observed. The adults are considered to rely more on aerobic metabolism, whereas anaerobic metabolism (glycolysis) may prevail in L(3)...
  34. Dubuisson M, Marchand C, Rees J. Fire fly luciferin as antioxidant and light emitter: the evolution of insect bioluminescence. Luminescence. 2004;19:339-44 pubmed
  35. Cai D, Marques M, Nogueira F. Full color modulation of firefly luciferase through engineering with unified Stark effect. J Phys Chem B. 2013;117:13725-30 pubmed publisher
    ..As an application, the widely observed pH-correlated color shift is proved to be associated with the local Stark field generated by the trace water-ions (vicinal hydronium and hydroxide ions) at active sites close to the OxyLH2-1. ..
  36. Poutiainen P, Palvimo J, Hinkkanen A, Valkonen A, Väisänen T, Laatikainen R, et al. Discovery of 5-benzyl-3-phenyl-4,5-dihydroisoxazoles and 5-benzyl-3-phenyl-1,4,2-dioxazoles as potent firefly luciferase inhibitors. J Med Chem. 2013;56:1064-73 pubmed publisher
    ..26 nM) and can thus be considered to belong to the most potent FLuc inhibitors reported thus far. Overall, the novel inhibitors form a unique molecular library for structure-activity relationship (SAR) analyses...
  37. Roda A, Roda B, Cevenini L, Michelini E, Mezzanotte L, Reschiglian P, et al. Analytical strategies for improving the robustness and reproducibility of bioluminescent microbial bioreporters. Anal Bioanal Chem. 2011;401:201-11 pubmed publisher
    ..The applicability of these bioreporters to real samples was demonstrated in tap water and wastewater treatment plant effluent samples spiked with copper and other metal ions...
  38. Nazari M, Hosseinkhani S. Design of disulfide bridge as an alternative mechanism for color shift in firefly luciferase and development of secreted luciferase. Photochem Photobiol Sci. 2011;10:1203-15 pubmed publisher
  39. Sagegami Oba R, Takahashi N, Oba Y. The evolutionary process of bioluminescence and aposematism in cantharoid beetles (Coleoptera: Elateroidea) inferred by the analysis of 18S ribosomal DNA. Gene. 2007;400:104-13 pubmed
  40. Mehrabi M, Hosseinkhani S, Ghobadi S. Stabilization of firefly luciferase against thermal stress by osmolytes. Int J Biol Macromol. 2008;43:187-91 pubmed publisher
    ..The unfolding curves of luciferase (obtained by far-UV CD spectra), indicated an irreversible thermal denaturation and raising of the midpoint of the unfolding transition temperature (T(m)) in the presence of osmolytes...
  41. Cheng G, Cohen L, Ndegwa D, Davis R. The flatworm spliced leader 3'-terminal AUG as a translation initiator methionine. J Biol Chem. 2006;281:733-43 pubmed
    ..Overall, our data have provided evidence that another function of flatworm spliced leader trans-splicing is to provide some recipient mRNAs with an initiator methionine for translation initiation...
  42. da Silva L, da Silva J. Theoretical modulation of the color of light emitted by firefly oxyluciferin. J Comput Chem. 2011;32:2654-63 pubmed publisher
    ..Arg220, Glu346, Ala350, Leu344 and adenosine-5'-monophosphate have blue-shifting effects, while His247, Phe249, Gly341, Thr253, and Ile288 exert a redshifting one...
  43. Ishikawa T, Jain N, Taketo M, Herschman H. Imaging cyclooxygenase-2 (Cox-2) gene expression in living animals with a luciferase knock-in reporter gene. Mol Imaging Biol. 2006;8:171-87 pubmed
    ..Cox-2luc/+ knock-in mice should provide a valuable tool to analyze Cox-2 expression in many disease models...
  44. Kanda G, Togashi R, Harashima H, Kamiya H. Effects of endogenous proteins and microRNA target sequence in a positive feedback system. Biol Pharm Bull. 2012;35:1534-8 pubmed
    ..The results obtained in this study suggested that silencing would be induced by mechanism(s) besides immunoreactions against reporter and activator proteins...
  45. Demary K. Sperm storage and viability in Photinus fireflies. J Insect Physiol. 2005;51:837-41 pubmed
    ..These studies contribute to our understanding of post-mating processes that may influence paternity success, and suggest that sexual conflict over control of fertilizations may occur in multiply mated firefly females...
  46. Fadnavis N, Seshadri R, Sheelu G, Madhuri K. Relevance of Frank's solvent classification as typically aqueous and typically non-aqueous to activities of firefly luciferase, alcohol dehydrogenase, and alpha-chymotrypsin in aqueous binaries. Arch Biochem Biophys. 2005;433:454-65 pubmed
    ..The interactions of TA solvents with proteins appear to be governed mainly by hydrophobic interactions while both hydrophobic and hydrophilic interactions play important role in case of TNA solvents...
  47. Laliberte J, Moss B. Appraising the apoptotic mimicry model and the role of phospholipids for poxvirus entry. Proc Natl Acad Sci U S A. 2009;106:17517-21 pubmed publisher
    ..Our results support a role for PS in poxvirus entry, but demonstrate that other phospholipids, not known to signal uptake of apoptotic debris, can function similarly...
  48. Rahebi J, Hardalaç F. A new approach to optic disc detection in human retinal images using the firefly algorithm. Med Biol Eng Comput. 2016;54:453-61 pubmed publisher
    ..firefly intelligent algorithm is an emerging intelligent algorithm that was inspired by the social behavior of fireflies. The population in this algorithm includes the fireflies, each of which has a specific rate of lighting or ..
  49. Viviani V, Okawachi F, Scorsato V, Abdalla F. CCD imaging of basal bioluminescence in larval fireflies: clues on the anatomic origin and evolution of bioluminescence. Photochem Photobiol Sci. 2008;7:448-52 pubmed publisher
    ..Through CCD imaging we report that larvae and pupae of the Brazilian fireflies Aspisoma lineatum and Cratomorphus sp emit a continuous weak glow throughout the entire body during all stages...
  50. Greenman L, Mazziotti D. Strong electron correlation in the decomposition reaction of dioxetanone with implications for firefly bioluminescence. J Chem Phys. 2010;133:164110 pubmed publisher
  51. Meyer Rochow V. Glowworms: a review of Arachnocampa spp. and kin. Luminescence. 2007;22:251-65 pubmed
    The term 'glowworm' is used in connection with the flightless females of lampyrid fireflies and to describe the luminescent larvae of certain fungus gnats that belong to the subfamilies Arachnocampinae, Keroplatinae and Macrocerinae of ..
  52. Zhang H, Bai H, Jiang T, Ma Z, Cheng Y, Zhou Y, et al. Quenching the firefly bioluminescence by various ions. Photochem Photobiol Sci. 2016;15:244-9 pubmed publisher
    ..Our study is anticipated to guide a more affordable design of quench-and-activate reagents in biomedicine and pharmaceutical analysis. ..
  53. Fraga H. Firefly luminescence: a historical perspective and recent developments. Photochem Photobiol Sci. 2008;7:146-58 pubmed publisher
    ..Those developments are here summarized and presented in a historical perspective...