sarcoptes scabiei

Summary

Summary: A species of mite that causes SCABIES in humans and sarcoptic mange in other animals. Specific variants of S. scabiei exist for humans and animals, but many have the ability to cross species and cause disease.

Top Publications

  1. Walton S, Holt D, Currie B, Kemp D. Scabies: new future for a neglected disease. Adv Parasitol. 2004;57:309-76 pubmed
    ..in both human and animal populations, resulting from infestation of the skin with the "itch" mite Sarcoptes scabiei. Despite the availability of effective chemotherapy the intensely itching lesions engender significant ..
  2. Mounsey K, Holt D, McCarthy J, Walton S. Identification of ABC transporters in Sarcoptes scabiei. Parasitology. 2006;132:883-92 pubmed
    We have identified and partially sequenced 8 ABC transporters from an EST dataset of Sarcoptes scabiei var. hominis, the causative agent of scabies...
  3. Dougall A, Holt D, Fischer K, Currie B, Kemp D, Walton S. Identification and characterization of Sarcoptes scabiei and Dermatophagoides pteronyssinus glutathione S-transferases: implication as a potential major allergen in crusted scabies. Am J Trop Med Hyg. 2005;73:977-84 pubmed
    The astigmatid mite Sarcoptes scabiei is the causative agent of scabies, a highly infectious parasitic disease of the skin...
  4. Tarigan S, Huntley J. Failure to protect goats following vaccination with soluble proteins of Sarcoptes scabiei: evidence for a role for IgE antibody in protection. Vet Parasitol. 2005;133:101-9 pubmed
    ..Soluble proteins from Sarcoptes scabiei were extracted then subjected to ion exchange chromatography, and proteins from the column were eluted step-..
  5. Mattsson J, Ljunggren E, Bergstrom K. Paramyosin from the parasitic mite Sarcoptes scabiei: cDNA cloning and heterologous expression. Parasitology. 2001;122:555-62 pubmed
    The burrowing mite Sarcoptes scabiei is the causative agent of the highly contagious disease sarcoptic mange or scabies. So far, there is no in vitro propagation system for S...
  6. Walton S. The immunology of susceptibility and resistance to scabies. Parasite Immunol. 2010;32:532-40 pubmed publisher
    The transmission of scabies occurs with the burrowing of Sarcoptes scabiei var. hominis mites into the skin. Infestation invariably leads to the development of localized cutaneous inflammation, pruritus and skin lesions...
  7. Willis C, Fischer K, Walton S, Currie B, Kemp D. Scabies mite inactivated serine protease paralogues are present both internally in the mite gut and externally in feces. Am J Trop Med Hyg. 2006;75:683-7 pubmed
    The scabies mite, Sarcoptes scabiei, is the causative agent of scabies, a disease that is common among disadvantaged populations and facilitates streptococcal infections with serious sequelae...
  8. Kuhn C, Lucius R, Matthes H, Meusel G, Reich B, Kalinna B. Characterisation of recombinant immunoreactive antigens of the scab mite Sarcoptes scabiei. Vet Parasitol. 2008;153:329-37 pubmed publisher
    ..Three of the proteins contain repetitive sequences which suggests that they might be involved in immune evasion. The application of these antigens in serodiagnosis and the suitability for diagnosis is discussed...
  9. Walton S, Beroukas D, Roberts Thomson P, Currie B. New insights into disease pathogenesis in crusted (Norwegian) scabies: the skin immune response in crusted scabies. Br J Dermatol. 2008;158:1247-55 pubmed publisher
    ..is a rare and severely debilitating disease characterized by infestation of the skin with up to millions of Sarcoptes scabiei mites, high total IgG levels, extremely high total IgE levels, and the development of hyperkeratotic skin ..

More Information

Publications62

  1. Currie B, Harumal P, McKinnon M, Walton S. First documentation of in vivo and in vitro ivermectin resistance in Sarcoptes scabiei. Clin Infect Dis. 2004;39:e8-12 pubmed
    ..5 years, respectively. As predicted, ivermectin resistance in scabies mites can develop after intensive ivermectin use...
  2. Alasaad S, Soglia D, Sarasa M, Soriguer R, Perez J, Granados J, et al. Skin-scale genetic structure of Sarcoptes scabiei populations from individual hosts: empirical evidence from Iberian ibex-derived mites. Parasitol Res. 2008;104:101-5 pubmed publisher
    The objective of the present study was to examine the extent of genetic diversity among Sarcoptes scabiei individuals belonging to different skin subunits of the body from individual mangy hosts...
  3. Elder B, Arlian L, Morgan M. Modulation of human dermal microvascular endothelial cells by Sarcoptes scabiei in combination with proinflammatory cytokines, histamine, and lipid-derived biologic mediators. Cytokine. 2009;47:103-11 pubmed publisher
    The ectoparasitic mite, Sarcoptes scabiei, produces molecules that depress initiation of host inflammatory and immune responses...
  4. Skerratt L, Campbell N, Murrell A, Walton S, Kemp D, Barker S. The mitochondrial 12S gene is a suitable marker of populations of Sarcoptes scabiei from wombats, dogs and humans in Australia. Parasitol Res. 2002;88:376-9 pubmed
    We sequenced part of the mitochondrial 12S ribosomal RNA gene of 23 specimens of Sarcoptes scabiei from eight wombats, one dog and three humans...
  5. Ryser Degiorgis M, Ryser A, Bacciarini L, Angst C, Gottstein B, Janovsky M, et al. Notoedric and sarcoptic mange in free-ranging lynx from Switzerland. J Wildl Dis. 2002;38:228-32 pubmed
    ..In the first two cases, Notoedres cati was isolated from the skin; in the third and fourth case, Sarcoptes scabiei was the cause of the infection; and in the fifth case, a mixed infection was diagnosed...
  6. Pasay C, Mounsey K, Stevenson G, Davis R, Arlian L, Morgan M, et al. Acaricidal activity of eugenol based compounds against scabies mites. PLoS ONE. 2010;5:e12079 pubmed publisher
    Human scabies is a debilitating skin disease caused by the "itch mite" Sarcoptes scabiei. Ordinary scabies is commonly treated with topical creams such as permethrin, while crusted scabies is treated with topical creams in ..
  7. Alasaad S, Walton S, Rossi L, Bornstein S, Abu Madi M, Soriguer R, et al. Sarcoptes-World Molecular Network (Sarcoptes-WMN): integrating research on scabies. Int J Infect Dis. 2011;15:e294-7 pubmed publisher
  8. Hay R, Steer A, Engelman D, Walton S. Scabies in the developing world--its prevalence, complications, and management. Clin Microbiol Infect. 2012;18:313-23 pubmed publisher
    ..The purpose of this review is to provide an update on the current position of scabies with regard to its complications and control in resource-poor countries...
  9. Jacobson M, Bornstein S, Palmer E, Wallgren P. Elimination of Sarcoptes scabiei in pig herds by single or double administrations of an avermectin. Acta Vet Scand. 2000;41:227-35 pubmed
    Attempts to eliminate Sarcoptes scabiei var. suis were made in 2 piglet producing herds by intramuscular injections with doramectin (Dectomax, Pfizer inc., New York, USA). No hygienic measures of the environments were undertaken...
  10. Alasaad S, Rossi L, Soriguer R, Rambozzi L, Soglia D, Perez J, et al. Sarcoptes mite from collection to DNA extraction: the lost realm of the neglected parasite. Parasitol Res. 2009;104:723-32 pubmed publisher
    Sarcoptes mite from collection to DNA extraction forms the cornerstone for studies on Sarcoptes scabiei. Whilst the new science era took a shy leap into the different facets of mite studies, the cornerstone was almost entirely neglected...
  11. León Vizcaíno L, Ruiz De Ybáñez M, Cubero M, Ortiz J, Espinosa J, Perez L, et al. Sarcoptic mange in Spanish ibex from Spain. J Wildl Dis. 1999;35:647-59 pubmed
    ..46 of the 63 (73%) ibex captured in different areas of the nature park were naturally infected with the Sarcoptes scabiei. Infected ibex were examined for number of mites during the initial stage of the disease (n = 3), in the ..
  12. Dupuy A, Dehen L, Bourrat E, Lacroix C, Benderdouche M, Dubertret L, et al. Accuracy of standard dermoscopy for diagnosing scabies. J Am Acad Dermatol. 2007;56:53-62 pubmed
    Scabies is a contagious skin infestation caused by the human mite Sarcoptes scabiei. The usual reference method for definitive diagnosis is ex vivo identification of the mite with microscopic examination of skin scrapings...
  13. Elder B, Arlian L, Morgan M. Sarcoptes scabiei (Acari: Sarcoptidae) mite extract modulates expression of cytokines and adhesion molecules by human dermal microvascular endothelial cells. J Med Entomol. 2006;43:910-5 pubmed
    The inflammatory and immune responses seen with the worldwide disease scabies, caused by the mite Sarcoptes scabiei (De Geer) (Acari: Sarcoptidae), are complex...
  14. Malik R, McKellar Stewart K, Sousa C, Krockenberger M, Pope S, Ihrke P, et al. Crusted scabies (sarcoptic mange) in four cats due to Sarcoptes scabiei infestation. J Feline Med Surg. 2006;8:327-39 pubmed
    ..Sarcoptic mange should be considered in the differential diagnosis of cats with non-pruritic crusting skin diseases, especially when there is contact with foxes or dogs, and when owners have itchy papular lesions...
  15. Heukelbach J, Feldmeier H. Scabies. Lancet. 2006;367:1767-74 pubmed
    ..We expect the future to bring more sensitive and specific clinical and laboratory-based diagnostic methods, as well as new therapeutic strategies...
  16. Pasay C, Walton S, Fischer K, Holt D, McCarthy J. PCR-based assay to survey for knockdown resistance to pyrethroid acaricides in human scabies mites (Sarcoptes scabiei var hominis). Am J Trop Med Hyg. 2006;74:649-57 pubmed
    ..we cloned 3711 and 6151 bp, respectively, of cDNA and genomic fragments of the Vssc gene from scabies mite, Sarcoptes scabiei. The sequence encompasses the major polymorphic amino acid residues associated with pyrethroid resistance...
  17. Mounsey K, McCarthy J, Walton S. Scratching the itch: new tools to advance understanding of scabies. Trends Parasitol. 2013;29:35-42 pubmed publisher
    Scabies remains a significant public health problem worldwide. Research into aspects of Sarcoptes scabiei biology and host-parasite interactions has been impeded by an inability to maintain mites in vitro and by limited access to ..
  18. León Vizcaíno L, Cubero M, González Capitel E, Simon M, Perez L, Rocío Ruiz deYbáñez M, et al. Experimental ivermectin treatment of sarcoptic mange and establishment of a mange-free population of Spanish ibex. J Wildl Dis. 2001;37:775-85 pubmed
    ..cure of all cases of sarcoptic mange in the chronic stage (phase 4); only three of six animals were free of Sarcoptes scabiei. The second experiment consisted on the application of a sanitation program in order to obtain a population ..
  19. Rambozzi L, Menzano A, Lavin S, Rossi L. Biotin-avidin amplified ELISA for detection of antibodies to Sarcoptes scabiei in chamois (Rupicapra spp.). Vet Res. 2004;35:701-8 pubmed
    ..An amplified capture enzyme-linked immunosorbent assay was developed to detect antibodies to Sarcoptes scabiei in chamois (Rupicapra spp.) serum...
  20. Walton S, McKinnon M, Pizzutto S, Dougall A, Williams E, Currie B. Acaricidal activity of Melaleuca alternifolia (tea tree) oil: in vitro sensitivity of sarcoptes scabiei var hominis to terpinen-4-ol. Arch Dermatol. 2004;140:563-6 pubmed
    To compare the acaricidal activity of Melaleuca alternifolia (tea tree) oil (TTO) and some of its individual active components on the itch mite Sarcoptes scabiei var hominis.
  21. Graczyk T, Mudakikwa A, Cranfield M, Eilenberger U. Hyperkeratotic mange caused by Sarcoptes scabiei (Acariformes: Sarcoptidae) in juvenile human-habituated mountain gorillas (Gorilla gorilla beringei). Parasitol Res. 2001;87:1024-8 pubmed
    ..Examination of skin scraping yielded a positive identification of adults and eggs of Sarcoptes scabiei mites. The gorillas were treated with ivermectin, 200 mg kg(-1). As S...
  22. Mounsey K, Holt D, Fischer K, Kemp D, Currie B, Walton S. Analysis of Sarcoptes scabiei finds no evidence of infection with Wolbachia. Int J Parasitol. 2005;35:131-5 pubmed
    ..PCR of Wolbachia surface protein (wsp), ftsZ and 16SrRNA genes from individual Sarcoptes scabiei mites obtained from a series of individual hosts, and database searches of an S. scabiei var...
  23. Rapp C, Morgan M, Arlian L. Presence of host immunoglobulin in the gut of Sarcoptes scabiei (Acari: Sarcoptidae). J Med Entomol. 2006;43:539-42 pubmed
    b>Sarcoptes scabiei (De Geer) mites burrow in the nonliving stratum corneum of the epidermis of their mammalian hosts. These mites ingest extracellular fluid (serum) that seeps into the burrow from the lower vascular dermis...
  24. Alasaad S, Rossi L, Heukelbach J, Pérez J, Hamarsheh O, Otiende M, et al. The neglected navigating web of the incomprehensibly emerging and re-emerging Sarcoptes mite. Infect Genet Evol. 2013;17:253-9 pubmed publisher
    ..Sarcoptes navigating web (Sarcoptes-NW) is intricate and uncertain, with unexplainable pathogenic flow. In this review we summarize by which routes, under what conditions and at what levels the Sarcoptes mite moves among its hosts...
  25. Bergström F, Reynolds S, Johnstone M, Pike R, Buckle A, Kemp D, et al. Scabies mite inactivated serine protease paralogs inhibit the human complement system. J Immunol. 2009;182:7809-17 pubmed publisher
    Infestation of skin by the parasitic itch mite Sarcoptes scabiei afflicts 300 million people worldwide and there is a need for novel and efficient therapies...
  26. Scott G, Chosidow O. European guideline for the management of scabies, 2010. Int J STD AIDS. 2011;22:301-3 pubmed publisher
    Transmission of the mite Sarcoptes scabiei generally occurs by protracted direct body contact; although in crusted scabies, transmission also occurs via infected clothing or bedding...
  27. Morrison D, Ljunggren E, Mattsson J. The origin of Sarcoptes scabiei in wombats. Parasitol Res. 2003;91:497-9 pubmed
    In 2002, Skerratt et al. phylogenetically analysed sequence data for several haplotypes of the parasitic mite Sarcoptes scabiei from wombat, human and dog hosts in Australia, to test scenarios concerning the origin and diversification of ..
  28. Terry B, Kanjah F, Sahr F, Kortequee S, Dukulay I, Gbakima A. Sarcoptes scabiei infestation among children in a displacement camp in Sierra Leone. Public Health. 2001;115:208-11 pubmed
    ..b>Sarcoptes scabiei var hominis was recovered from 84 (67%) of the 125 skin scrapings examined...
  29. Abdel Ghaffar F, Al Quraishy S, Sobhy H, Semmler M. Neem seed extract shampoo, Wash Away Louse, an effective plant agent against Sarcoptes scabiei mites infesting dogs in Egypt. Parasitol Res. 2008;104:145-8 pubmed publisher
    ..shampoo Wash Away Louse, provided by Alpha-Biocare GmbH, Düsseldorf (Germany), was investigated against Sarcoptes scabiei infesting dogs in Egypt. Ten naturally infested dogs were collected from different areas in the Nile delta...
  30. Rodríguez Cadenas F, Carbajal González M, Fregeneda Grandes J, Aller Gancedo J, Rojo Vazquez F. Clinical evaluation and antibody responses in sheep after primary and secondary experimental challenges with the mange mite Sarcoptes scabiei var. ovis. Vet Immunol Immunopathol. 2010;133:109-16 pubmed publisher
    ..responses in sheep after primary (n=10) and secondary (n=4) experimental challenges with the mange mite Sarcoptes scabiei var. ovis were studied...
  31. Walton S, Pizzutto S, Slender A, Viberg L, Holt D, Hales B, et al. Increased allergic immune response to Sarcoptes scabiei antigens in crusted versus ordinary scabies. Clin Vaccine Immunol. 2010;17:1428-38 pubmed publisher
    Scabies, a parasitic skin infestation by the burrowing "itch" mite Sarcoptes scabiei, causes significant health problems for children and adults worldwide...
  32. Fourie J, Horak I, de la Puente Redondo V. Efficacy of a spot-on formulation of pyriprole on dogs infested with Sarcoptes scabiei. Vet Rec. 2010;167:442-5 pubmed publisher
    ..5 per cent moxidectin (Advocate; Bayer Animal Health) against Sarcoptes scabiei on dogs, 20 naturally infested adult dogs were ranked according to their pretreatment mite counts, allocated ..
  33. Alasaad S, Ndeereh D, Rossi L, Bornstein S, Permunian R, Soriguer R, et al. The opportunistic Sarcoptes scabiei: a new episode from giraffe in the drought-suffering Kenya. Vet Parasitol. 2012;185:359-63 pubmed publisher
    ..Affected giraffes were captured and successfully treated. The possible relations between this outbreak and annual seasons, animal age-classes and sex, and spatial distribution are discussed...
  34. Fthenakis G, Karagiannidis A, Alexopoulos C, Brozos C, Papadopoulos E. Effects of sarcoptic mange on the reproductive performance of ewes and transmission of Sarcoptes scabiei to newborn lambs. Vet Parasitol. 2001;95:63-71 pubmed
    ..Sarcoptic mange was observed in the offspring of infested ewes after 30 days and in the offspring of uninfested controls 60 days after their birth...
  35. Pasay C, Rothwell J, Mounsey K, Kelly A, Hutchinson B, Miezler A, et al. An exploratory study to assess the activity of the acarine growth inhibitor, fluazuron, against Sarcoptes scabei infestation in pigs. Parasit Vectors. 2012;5:40 pubmed publisher
    ..To identify alternate acaricides, we undertook a pilot study of the in vivo activity of the benzoylphenyl urea inhibitor of chitin synthesis, fluazuron, in pigs with sarcoptic mange...
  36. Arlian L, Morgan M, Arends J. Immunologic cross-reactivity among various strains of Sarcoptes scabiei. J Parasitol. 1996;82:66-72 pubmed
    Varieties of Sarcoptes scabiei from different hosts are highly host specific but they are morphologically indistinguishable...
  37. Rampton M, Walton S, Holt D, Pasay C, Kelly A, Currie B, et al. Antibody responses to Sarcoptes scabiei apolipoprotein in a porcine model: relevance to immunodiagnosis of recent infection. PLoS ONE. 2013;8:e65354 pubmed publisher
    ..The recombinant Sarcoptes scabiei apolipoprotein antigen Sar s 14...
  38. Alasaad S, Granados J, Fandos P, Cano Manuel F, Soriguer R, Pérez J. The use of radio-collars for monitoring wildlife diseases: a case study from Iberian ibex affected by Sarcoptes scabiei in Sierra Nevada, Spain. Parasit Vectors. 2013;6:242 pubmed publisher
  39. Fischer K, Langendorf C, Irving J, Reynolds S, Willis C, Beckham S, et al. Structural mechanisms of inactivation in scabies mite serine protease paralogues. J Mol Biol. 2009;390:635-45 pubmed publisher
    The scabies mite (Sarcoptes scabiei) is a parasite responsible for major morbidity in disadvantaged communities and immuno-compromised patients worldwide...
  40. Kessler E, Matthes H, Schein E, Wendt M. Detection of antibodies in sera of weaned pigs after contact infection with Sarcoptes scabiei var. suis and after treatment with an antiparasitic agent by three different indirect ELISAs. Vet Parasitol. 2003;114:63-73 pubmed
    Three commercial enzyme-linked immunosorbent assays (ELISAs) were compared for the detection of antibodies to Sarcoptes scabiei var. suis using experimental sera of six 8-week-old pigs after contact infection with Sarcoptes scabiei var...
  41. Arlian L, Morgan M, Neal J. Modulation of cytokine expression in human keratinocytes and fibroblasts by extracts of scabies mites. Am J Trop Med Hyg. 2003;69:652-6 pubmed
    b>Sarcoptes scabiei lives in the stratum corneum of its mammalian host. Keratinocytes and fibroblasts are among the first cells to encounter the burrowing mite and its products...
  42. Mounsey K, Holt D, McCarthy J, Currie B, Walton S. Scabies: molecular perspectives and therapeutic implications in the face of emerging drug resistance. Future Microbiol. 2008;3:57-66 pubmed publisher
    ..These may assist in overcoming many of the current difficulties in monitoring treatment efficacy and allow the development of more sensitive tools for monitoring emerging resistance...
  43. Katsumata K, Katsumata K. Simple method of detecting sarcoptes scabiei var hominis mites among bedridden elderly patients suffering from severe scabies infestation using an adhesive-tape. Intern Med. 2006;45:857-9 pubmed
    ..Thus, we tried to catch mites using a strong transparent adhesive tape commercially available for packing use as an alternative method for the diagnosis of severe scabies infestation...
  44. Mounsey K, Holt D, McCarthy J, Currie B, Walton S. Longitudinal evidence of increasing in vitro tolerance of scabies mites to ivermectin in scabies-endemic communities. Arch Dermatol. 2009;145:840-1 pubmed publisher
  45. Bates P. Sarcoptic mange (Sarcoptes scabiei var vulpes) in a red fox (Vulpes vulpes) population in north-west Surrey. Vet Rec. 2003;152:112-4 pubmed
  46. Skerratt L. Cellular response in the dermis of common wombats (Vombatus ursinus) infected with Sarcoptes scabiei var. wombati. J Wildl Dis. 2003;39:193-202 pubmed
    ..wombats (Vombatus ursinus) with sarcoptic mange exhibited some typical aspects of an immune response to Sarcoptes scabiei. There was an induction phase for wombats experimentally infected with S...
  47. Alasaad S, Oleaga A, Casais R, Rossi L, Min A, Soriguer R, et al. Temporal stability in the genetic structure of Sarcoptes scabiei under the host-taxon law: empirical evidences from wildlife-derived Sarcoptes mite in Asturias, Spain. Parasit Vectors. 2011;4:151 pubmed publisher
  48. Arlian L, Morgan M, Estes S, Walton S, Kemp D, Currie B. Circulating IgE in patients with ordinary and crusted scabies. J Med Entomol. 2004;41:74-7 pubmed
    ..scabies were screened by immunoblotting for IgE- and IgG-specific proteins in an extract of the mite, Sarcoptes scabiei variety canis. Sera from atopic individuals without sensitivity to house dust mites were used as controls...
  49. Hengge U, Currie B, Jäger G, Lupi O, Schwartz R. Scabies: a ubiquitous neglected skin disease. Lancet Infect Dis. 2006;6:769-79 pubmed
    ..Other problems such as post-scabies eczema and reinfestation, and newer treatments such as ivermectin are also discussed...
  50. Prins C, Stucki L, French L, Saurat J, Braun R. Dermoscopy for the in vivo detection of sarcoptes scabiei. Dermatology. 2004;208:241-3 pubmed
    ..Dermoscopy is a useful tool for the diagnosis of scabies either as a diagnostic test or to guide the traditional diagnostic tests...
  51. Haas N, Wagemann B, Hermes B, Henz B, Heile C, Schein E. Crossreacting IgG antibodies against fox mite antigens in human scabies. Arch Dermatol Res. 2005;296:327-31 pubmed
    ..In contrast to human mites, red fox mites (Sarcoptes scabiei var...
  52. Morgan M, Arlian L, Markey M. Sarcoptes scabiei mites modulate gene expression in human skin equivalents. PLoS ONE. 2013;8:e71143 pubmed publisher
    The ectoparasitic mite, Sarcoptes scabiei that burrows in the epidermis of mammalian skin has a long co-evolution with its hosts...
  53. Fourie L, Heine J, Horak I. The efficacy of an imidacloprid/moxidectin combination against naturally acquired Sarcoptes scabiei infestations on dogs. Aust Vet J. 2006;84:17-21 pubmed
    ..5% w/v) combination (Advocate Bayer HealthCare, Animal Health) with that of selamectin for the treatment of Sarcoptes scabiei on dogs...