pyroglyphidae

Summary

Summary: Family of house dust mites, in the superfamily Analgoidea, order Astigmata. They include the genera Dermatophagoides and Euroglyphus.

Top Publications

  1. Mushaben E, Kramer E, Brandt E, Khurana Hershey G, Le Cras T. Rapamycin attenuates airway hyperreactivity, goblet cells, and IgE in experimental allergic asthma. J Immunol. 2011;187:5756-63 pubmed publisher
    ..These findings highlight the importance of the mTOR pathway in allergic airway disease...
  2. Kool M, Willart M, van Nimwegen M, Bergen I, Pouliot P, Virchow J, et al. An unexpected role for uric acid as an inducer of T helper 2 cell immunity to inhaled antigens and inflammatory mediator of allergic asthma. Immunity. 2011;34:527-40 pubmed publisher
    ..These findings provide further molecular insight into Th2 cell development and identify UA as an essential initiator and amplifier of allergic inflammation...
  3. Nakano H, Free M, Whitehead G, Maruoka S, Wilson R, Nakano K, et al. Pulmonary CD103(+) dendritic cells prime Th2 responses to inhaled allergens. Mucosal Immunol. 2012;5:53-65 pubmed publisher
    ..Low-level antigen presentation by CD103(+) DCs was necessary, but not sufficient for Th2 priming. Together, these findings show that CD103(+) DCs have a significant role in priming Th2 responses to inhaled allergens. ..
  4. Glasgow N, Ponsonby A, Kemp A, Tovey E, Van Asperen P, McKay K, et al. Feather bedding and childhood asthma associated with house dust mite sensitisation: a randomised controlled trial. Arch Dis Child. 2011;96:541-7 pubmed publisher
  5. Johnson J, Roos A, Berg T, Nord M, Fuxe J. Chronic respiratory aeroallergen exposure in mice induces epithelial-mesenchymal transition in the large airways. PLoS ONE. 2011;6:e16175 pubmed publisher
  6. Jacquet A. The role of the house dust mite-induced innate immunity in development of allergic response. Int Arch Allergy Immunol. 2011;155:95-105 pubmed publisher
  7. Willart M, Deswarte K, Pouliot P, Braun H, Beyaert R, Lambrecht B, et al. Interleukin-1? controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33. J Exp Med. 2012;209:1505-17 pubmed publisher
    ..These findings put IL-1? upstream in the cytokine cascade leading to epithelial and DC activation in response to inhaled HDM allergen...
  8. van de Pol M, Lutter R, van Ree R, van der Zee J. Increase in allergen-specific IgE and ex vivo Th2 responses after a single bronchial challenge with house dust mite in allergic asthmatics. Allergy. 2012;67:67-73 pubmed publisher
  9. Hammad H, Plantinga M, Deswarte K, Pouliot P, Willart M, Kool M, et al. Inflammatory dendritic cells--not basophils--are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen. J Exp Med. 2010;207:2097-111 pubmed publisher
    ..Inflammatory DCs were necessary and sufficient for induction of Th2 immunity and features of asthma, whereas basophils were not required. We favor a model whereby DCs initiate and basophils amplify Th2 immunity to HDM allergen...

More Information

Publications62

  1. Arora M, Poe S, Oriss T, Krishnamoorthy N, Yarlagadda M, Wenzel S, et al. TLR4/MyD88-induced CD11b+Gr-1 int F4/80+ non-migratory myeloid cells suppress Th2 effector function in the lung. Mucosal Immunol. 2010;3:578-93 pubmed publisher
    ..These data suggest that CD11b(+)Gr1(int)F4/80(+) cells contribute to the protective effects of LPS in allergic asthma by tempering Th2 effector function in the tissue...
  2. Yao X, Fredriksson K, Yu Z, Xu X, Raghavachari N, Keeran K, et al. Apolipoprotein E negatively regulates house dust mite-induced asthma via a low-density lipoprotein receptor-mediated pathway. Am J Respir Crit Care Med. 2010;182:1228-38 pubmed publisher
    ..Distinct sets of corticosteroid-unresponsive genes modulate disease severity in asthma...
  3. Ryu J, Yoo J, Kim M, Hwang S, Ahn K, Ryu J, et al. Distinct TLR-mediated pathways regulate house dust mite-induced allergic disease in the upper and lower airways. J Allergy Clin Immunol. 2013;131:549-61 pubmed publisher
  4. Fredriksson K, Fielhaber J, Lam J, Yao X, Meyer K, Keeran K, et al. Paradoxical effects of rapamycin on experimental house dust mite-induced asthma. PLoS ONE. 2012;7:e33984 pubmed publisher
    ..Thus, consistent with the context-dependent effects of rapamycin on inflammation, the timing of mTOR inhibition may be an important determinant of efficacy and toxicity in HDM-induced asthma...
  5. Van der Velden J, Barker D, Barcham G, Koumoundouros E, Snibson K. Assessment of peripheral airway function following chronic allergen challenge in a sheep model of asthma. PLoS ONE. 2011;6:e28740 pubmed publisher
    ..The aim of the current study was to characterize progressive changes in small airway function in sheep repeatedly challenged with house dust mite (HDM) allergen...
  6. Bessot J, Pauli G. Mite allergens: an overview. Eur Ann Allergy Clin Immunol. 2011;43:141-56 pubmed
    Mite allergens from the Pyroglyphidae family are the most frequent and potent sources of perennial asthma and rhinitis...
  7. Hales B, Chai L, Elliot C, Pearce L, Zhang G, Heinrich T, et al. Antibacterial antibody responses associated with the development of asthma in house dust mite-sensitised and non-sensitised children. Thorax. 2012;67:321-7 pubmed publisher
    ..Infants who develop house dust mite (HDM) allergy and HDM-sensitised children with severe persistent asthma have low antibody responses to the P6 antigen of Haemophilus influenzae...
  8. Thomas W. Geography of house dust mite allergens. Asian Pac J Allergy Immunol. 2010;28:211-24 pubmed
    ..To consider how the different distribution of house dust mites and their species in different geographical locations affects the allergens in the environment and their use...
  9. Le Cras T, Acciani T, Mushaben E, Kramer E, Pastura P, Hardie W, et al. Epithelial EGF receptor signaling mediates airway hyperreactivity and remodeling in a mouse model of chronic asthma. Am J Physiol Lung Cell Mol Physiol. 2011;300:L414-21 pubmed publisher
    ..This study demonstrates that EGFR signaling, especially in the airway epithelium, plays an important role in mediating AHR and remodeling in a chronic allergic asthma model...
  10. Van der Velden J, Barker D, Barcham G, Koumoundouros E, Snibson K. Increased vascular density is a persistent feature of airway remodeling in a sheep model of chronic asthma. Exp Lung Res. 2012;38:307-15 pubmed publisher
  11. McHugh B, MacGinnitie A. Indoor allergen sensitization and the risk of asthma and eczema in children in Pittsburgh. Allergy Asthma Proc. 2011;32:372-6 pubmed publisher
    ..Our result suggests that allergic sensitization is associated with these diseases, but the implicated allergens may vary...
  12. van de Pol M, Lutter R, Smids B, Weersink E, van der Zee J. Synbiotics reduce allergen-induced T-helper 2 response and improve peak expiratory flow in allergic asthmatics. Allergy. 2011;66:39-47 pubmed publisher
    ..Previous studies suggest that pre/probiotics can be used in the prevention and treatment of early allergic disease in newborns and young children...
  13. Marichal T, Bedoret D, Mesnil C, Pichavant M, Goriely S, Trottein F, et al. Interferon response factor 3 is essential for house dust mite-induced airway allergy. J Allergy Clin Immunol. 2010;126:836-844.e13 pubmed publisher
    ..Pattern-recognition receptors (PRRs) are critically involved in the pathophysiology of airway allergy, yet most of the signaling pathways downstream of PRRs implicated in allergic airway sensitization remain unknown...
  14. Van der Velden J, Barker D, Barcham G, Koumoundouros E, Snibson K. Increased mast cell density and airway responses to allergic and non-allergic stimuli in a sheep model of chronic asthma. PLoS ONE. 2012;7:e37161 pubmed publisher
    ..The aim of the current study was to characterise temporal changes in airway MC density and correlate these changes with functional airway responses in sheep chronically challenged with house dust mite (HDM) allergen...
  15. Royer P, Emara M, Yang C, Al Ghouleh A, Tighe P, Jones N, et al. The mannose receptor mediates the uptake of diverse native allergens by dendritic cells and determines allergen-induced T cell polarization through modulation of IDO activity. J Immunol. 2010;185:1522-31 pubmed publisher
    ..In conclusion, our work demonstrates a major role for MR in glycoallergen recognition and in the development of Th2 responses...
  16. Rijssenbeek Nouwens L, Bel E. High-altitude treatment: a therapeutic option for patients with severe, refractory asthma?. Clin Exp Allergy. 2011;41:775-82 pubmed publisher
    ..In this narrative review, we will discuss why high-altitude treatment might be a promising therapeutic option for patients who suffer from this disabling disease...
  17. Kashyap M, Rochman Y, Spolski R, Samsel L, Leonard W. Thymic stromal lymphopoietin is produced by dendritic cells. J Immunol. 2011;187:1207-11 pubmed publisher
    ..These data suggested that DCs not only respond to TSLP but also are a source of TSLP during pathogen and/or allergen encounter. ..
  18. Bush R, Swenson C, Fahlberg B, Evans M, Esch R, Morris M, et al. House dust mite sublingual immunotherapy: results of a US trial. J Allergy Clin Immunol. 2011;127:974-81.e1-7 pubmed publisher
    ..Few trials of sublingual immunotherapy (SLIT) in the United States have been reported...
  19. Daschner A, Rodero M, De Frutos C, Valls A, Cuellar C. Chronic urticaria is associated with a differential helminth-arthropod-related atopy phenotype. J Dermatol. 2010;37:780-5 pubmed publisher
    ..03), whereas no difference could be stated for PMD sensitization. Compared to RCBA patients, both CU/As+ and CU/As- patients have a higher clinically relevant sensitization rate against HDM, thus displaying a differential atopy phenotype...
  20. Jacquet A. The role of innate immunity activation in house dust mite allergy. Trends Mol Med. 2011;17:604-11 pubmed publisher
    ..This review highlights how HDM allergens, together with microbial compounds, promote allergic responses through pattern recognition receptor-dependent pathways...
  21. Fuiano N, Incorvaia C. Dissecting the causes of atopic dermatitis in children: less foods, more mites. Allergol Int. 2012;61:231-43 pubmed publisher
    ..As far as the causal diagnosis of AD is concerned, there is notable evidence supporting the capacity of the atopy patch test (APT) to reproduce the pathophysiologic events of AD. This makes APT a valuable diagnostic tool for AD...
  22. Gregory L, Lloyd C. Orchestrating house dust mite-associated allergy in the lung. Trends Immunol. 2011;32:402-11 pubmed publisher
    ..We review the myriad ways in which HDM allergic responses are orchestrated. Understanding the molecular pathways that elicit HDM-associated pathology is likely to reveal novel targets for therapeutic intervention...
  23. Tovey E, Ferro A. Time for new methods for avoidance of house dust mite and other allergens. Curr Allergy Asthma Rep. 2012;12:465-77 pubmed publisher
    ..It will also require developing better proxy measures of chronic exposure, identifying markers for the sub-set of people who benefit, and integrating this with strategies addressing other domestic exposures and lifestyle factors...
  24. Fattouh R, Midence N, Arias K, Johnson J, Walker T, Goncharova S, et al. Transforming growth factor-beta regulates house dust mite-induced allergic airway inflammation but not airway remodeling. Am J Respir Crit Care Med. 2008;177:593-603 pubmed publisher
    ..Transforming growth factor (TGF)-beta is a powerful regulator of both the tissue repair and inflammatory responses, and numerous experimental and clinical studies suggest that it may play an integral role in the pathogenesis of asthma...
  25. Shen H, Tam M, Huang C, Chou H, Tai H, Chen Y, et al. Homology modeling and monoclonal antibody binding of the Der f 7 dust mite allergen. Immunol Cell Biol. 2011;89:225-30 pubmed publisher
    ..The properties of Der f 7 that can be deduced from the model provide avenues for further characterizing these allergens, their IgE binding structures and biological properties that can enhance allergenicity...
  26. Müller T, Vieira R, Grimm M, Dürk T, Cicko S, Zeiser R, et al. A potential role for P2X7R in allergic airway inflammation in mice and humans. Am J Respir Cell Mol Biol. 2011;44:456-64 pubmed publisher
    ..Our data suggest that targeting P2X?R on hematopoietic cells (e.g., DCs or eosinophils) might be a new therapeutic option for the treatment of asthma...
  27. Marsella R, Samuelson D. Unravelling the skin barrier: a new paradigm for atopic dermatitis and house dust mites. Vet Dermatol. 2009;20:533-40 pubmed publisher
    ..It is proposed that the paradigm of canine AD as primarily due to immunologic aberration ('inside/outside') should be shifted to include a primary defect in barrier function ('outside/inside')...
  28. Simpson A, Tan V, Winn J, Svensén M, Bishop C, Heckerman D, et al. Beyond atopy: multiple patterns of sensitization in relation to asthma in a birth cohort study. Am J Respir Crit Care Med. 2010;181:1200-6 pubmed publisher
    ..The pattern of IgE response (over time or to specific allergens) may reflect different atopic vulnerabilities which are related to the presence of asthma in a fundamentally different way from current definition of atopy...
  29. Eifan A, Akkoc T, Yildiz A, Keles S, Ozdemir C, Bahceciler N, et al. Clinical efficacy and immunological mechanisms of sublingual and subcutaneous immunotherapy in asthmatic/rhinitis children sensitized to house dust mite: an open randomized controlled trial. Clin Exp Allergy. 2010;40:922-32 pubmed publisher
    ..In children, the clinical efficacy and immunological mechanisms of sublingual immunotherapy (SLIT) compared with subcutaneous immunotherapy (SCIT) is still to be elucidated...
  30. Sears M, Greene J, Willan A, Wiecek E, Taylor D, Flannery E, et al. A longitudinal, population-based, cohort study of childhood asthma followed to adulthood. N Engl J Med. 2003;349:1414-22 pubmed
    ..The outcome of childhood asthma in adults has been described in high-risk cohorts, but few population-based studies have reported the risk factors for persistence and relapse...
  31. Compalati E, Passalacqua G, Bonini M, Canonica G. The efficacy of sublingual immunotherapy for house dust mites respiratory allergy: results of a GA2LEN meta-analysis. Allergy. 2009;64:1570-9 pubmed publisher
    ..These findings suggest that more data are needed, derived from large-population-based high quality studies, and corroborated by objective outcomes, mainly for AA...
  32. Salib R, Lau L, Howarth P. The novel use of the human nasal epithelial cell line RPMI 2650 as an in vitro model to study the influence of allergens and cytokines on transforming growth factor-beta gene expression and protein release. Clin Exp Allergy. 2005;35:811-9 pubmed
    ..To address this we have utilized the RPMI 2650 human nasal epithelial cell line, which has some features that closely resemble normal nasal epithelium and has been reported to secrete a TGF-beta-like molecule...
  33. Varney V, Tabbah K, Mavroleon G, Frew A. Usefulness of specific immunotherapy in patients with severe perennial allergic rhinitis induced by house dust mite: a double-blind, randomized, placebo-controlled trial. Clin Exp Allergy. 2003;33:1076-82 pubmed
    ..To evaluate the effectiveness of specific immunotherapy (SIT) in patients with severe house dust mite (HDM)-induced perennial allergic rhinitis using diary cards and objective endpoints...
  34. Saglani S, Mathie S, Gregory L, Bell M, Bush A, Lloyd C. Pathophysiological features of asthma develop in parallel in house dust mite-exposed neonatal mice. Am J Respir Cell Mol Biol. 2009;41:281-9 pubmed publisher
    ..Importantly, all abnormalities developed in parallel, not sequentially, between 2 and 3 weeks of age...
  35. Koumoundouros E, Bischof R, Meeusen E, Mareels I, Snibson K. Chronic airway disease: deteriorating pulmonary function in sheep associated with repeated challenges of house dust mite. Exp Lung Res. 2006;32:321-30 pubmed
    ..In conclusion, sheep chronically challenged intralung with HDM consistently develop airway hyperresponsiveness and eosinophilia, whereas allergen-specific bronchoconstriction is observed in just over half of these sheep...
  36. Castro Almarales R, Mateo Morejón M, Naranjo Robalino R, Navarro Viltre B, Alvarez Castelló M, Ronquillo Díaz M, et al. Correlation between skin tests to Dermatophagoides pteronyssinus, Dermatophagoides siboney and Blomia tropicalis in Cuban asthmatics. Allergol Immunopathol (Madr). 2006;34:23-6 pubmed
    ..The aim of this study was to determine the degree of polysensitization and correlation of the skin prick test (SPT) reaction size to these mites in asthmatic patients...
  37. de Halleux S, Stura E, VanderElst L, Carlier V, Jacquemin M, Saint Remy J. Three-dimensional structure and IgE-binding properties of mature fully active Der p 1, a clinically relevant major allergen. J Allergy Clin Immunol. 2006;117:571-6 pubmed
    ..Der p 1 is a 25-kd allergen with cysteine protease activity. Sensitization to Der p 1 affects a large proportion of individuals with allergy, resulting in rhinitis, asthma, and/or atopic dermatitis...
  38. O Hehir R, Gardner L, de Leon M, Hales B, Biondo M, Douglass J, et al. House dust mite sublingual immunotherapy: the role for transforming growth factor-beta and functional regulatory T cells. Am J Respir Crit Care Med. 2009;180:936-47 pubmed publisher
    ..Sublingual allergen-specific immunotherapy is gaining popularity for treatment of allergic diseases, but underlying immunological mechanisms are unresolved...
  39. Terreehorst I, Hak E, Oosting A, Tempels Pavlica Z, de Monchy J, Bruijnzeel Koomen C, et al. Evaluation of impermeable covers for bedding in patients with allergic rhinitis. N Engl J Med. 2003;349:237-46 pubmed
  40. Ogawa T, Takai T, Kato T, Kikuchi Y, Niyonsaba F, Ikeda S, et al. Upregulation of the release of granulocyte-macrophage colony-stimulating factor from keratinocytes stimulated with cysteine protease activity of recombinant major mite allergens, Der f 1 and Der p 1. Int Arch Allergy Immunol. 2008;146:27-35 pubmed
  41. Wong C, Li M, Wang C, Ip W, Tian Y, Lam C. House dust mite allergen Der p 1 elevates the release of inflammatory cytokines and expression of adhesion molecules in co-culture of human eosinophils and bronchial epithelial cells. Int Immunol. 2006;18:1327-35 pubmed
    ..As an allergen, HDM could therefore induce the release of inflammatory cytokines and expression of adhesion molecules from the interaction of human eosinophils and bronchial epithelial cells...
  42. Gøtzsche P, Johansen H. House dust mite control measures for asthma: systematic review. Allergy. 2008;63:646-59 pubmed publisher
    ..04, 95% CI -0.15 to 0.07) or in medication usage (standardized mean difference -0.06, 95% CI -0.18 to 0.07). Chemical and physical methods aimed at reducing exposure to house dust mite allergens cannot be recommended...
  43. Woodcock A, Forster L, Matthews E, Martin J, Letley L, Vickers M, et al. Control of exposure to mite allergen and allergen-impermeable bed covers for adults with asthma. N Engl J Med. 2003;349:225-36 pubmed
    ..The effectiveness of avoidance of house-dust-mite allergen (Dermatophagoides pteronyssinus 1 [Der p1]) in the management of asthma is uncertain...
  44. Chapman M, Wunschmann S, Pomes A. Proteases as Th2 adjuvants. Curr Allergy Asthma Rep. 2007;7:363-7 pubmed
    ..Thus although mite proteases allergens may act as Th2 adjuvants, a paradoxical effect is that other allergens may elicit strong Th2 responses in the absence of enzyme activity...
  45. Arshad S. Does exposure to indoor allergens contribute to the development of asthma and allergy?. Curr Allergy Asthma Rep. 2010;10:49-55 pubmed publisher
    ..However, in recent years, evidence has accumulated that exposure to indoor allergen causes asthma and allergy, but this effect may depend on dose and type of allergen as well as the underlying genetic susceptibility of the child...
  46. McGee H, Stallworth A, Agrawal T, Shao Z, Lorence L, Agrawal D. Fms-like tyrosine kinase 3 ligand decreases T helper type 17 cells and suppressors of cytokine signaling proteins in the lung of house dust mite-sensitized and -challenged mice. Am J Respir Cell Mol Biol. 2010;43:520-9 pubmed publisher
  47. Phipps S, Lam C, Kaiko G, Foo S, Collison A, Mattes J, et al. Toll/IL-1 signaling is critical for house dust mite-specific helper T cell type 2 and type 17 [corrected] responses. Am J Respir Crit Care Med. 2009;179:883-93 pubmed publisher
  48. Werfel T, Breuer K, Rueff F, Przybilla B, Worm M, Grewe M, et al. Usefulness of specific immunotherapy in patients with atopic dermatitis and allergic sensitization to house dust mites: a multi-centre, randomized, dose-response study. Allergy. 2006;61:202-5 pubmed
    ..Therefore, a multi-centre, randomized dose-response trial, double-blind with respect to the efficacy of a biologically standardized depot house dust mite preparation was performed...
  49. Zhang J, Saint Remy J, Garrod D, Robinson C. Comparative enzymology of native and recombinant house dust mite allergen Der p 1. Allergy. 2009;64:469-77 pubmed publisher
    ..Our aim was to compare the enzymology of recombinant and native forms of Der p 1 to establish if an easily expressed recombinant form of Der p 1 could be used as a drug discovery tool...
  50. Prasad C, Hogan M, Peele K, Wilson N. Effect of evaporative coolers on skin test reactivity to dust mites and molds in a desert environment. Allergy Asthma Proc. 2009;30:624-7 pubmed publisher
    ..Patients with asthma in homes with evaporative coolers should be counseled about the risk for mold and dust-mite allergy. Humidity monitoring, cooler maintenance, and filter changes should be discussed...
  51. Mariana A, Santana Raj A, Ho T, Tan S, Zuhaizam H. Scanning electron micrographs of two species of Sturnophagoides (Acari: Astigmata: Pyroglyphidae) mites in Malaysia. Trop Biomed. 2008;25:217-24 pubmed
    ..Sturnophagoides halterophilus can be differentiated from S. brasiliensis by their expanded genu and femur of leg I. The differences in morphology of male and female S. brasiliensis are also discussed...
  52. Thomas W, Hales B. T and B cell responses to HDM allergens and antigens. Immunol Res. 2007;37:187-99 pubmed
    ..The major allergens are not produced in higher amounts than many of the poorly non-allergenic proteins. The non-allergenic mite ferritin antigen shows high T cell proliferative responses with mixed cytokine production...
  53. Kato T, Takai T, Fujimura T, Matsuoka H, Ogawa T, Murayama K, et al. Mite serine protease activates protease-activated receptor-2 and induces cytokine release in human keratinocytes. Allergy. 2009;64:1366-74 pubmed publisher
    ..Mite-derived proteases have been suggested to be involved in the pathogenesis of allergies; however, whether mite-derived serine protease activity can stimulate keratinocytes remains unknown...