opossums

Summary

Summary: New World marsupials of the family Didelphidae. Opossums are omnivorous, largely nocturnal and arboreal MAMMALS, grow to about three feet in length, including the scaly prehensile tail, and have an abdominal pouch in which the young are carried at birth.

Top Publications

  1. Elsheikha H, Lacher D, Mansfield L. Phylogenetic relationships of Sarcocystis neurona of horses and opossums to other cyst-forming coccidia deduced from SSU rRNA gene sequences. Parasitol Res. 2005;97:345-57 pubmed
    ..performed to examine the origin, phylogeny, and biogeographic relationships of Sarcocystis neurona isolates from opossums and horses from the State of Michigan, USA, in relation to other cyst-forming coccidia...
  2. Karim Z, Gerard B, Bakouh N, Alili R, Leroy C, Beck L, et al. NHERF1 mutations and responsiveness of renal parathyroid hormone. N Engl J Med. 2008;359:1128-35 pubmed publisher
    ..These NHERF1 mutations suggest a previously unrecognized cause of renal phosphate loss in humans...
  3. Mladinic M, Lefevre C, Del Bel E, Nicholls J, Digby M. Developmental changes of gene expression after spinal cord injury in neonatal opossums. Brain Res. 2010;1363:20-39 pubmed publisher
    ..In opossums there is a critical period of development when regeneration stops being possible: at 9 days postnatal cervical ..
  4. Rejmanek D, Miller M, Grigg M, Crosbie P, Conrad P. Molecular characterization of Sarcocystis neurona strains from opossums (Didelphis virginiana) and intermediate hosts from Central California. Vet Parasitol. 2010;170:20-9 pubmed publisher
    ..b>Opossums (Didelphis virginiana), the only known definitive hosts for S...
  5. Horovitz I, Martin T, Bloch J, Ladevèze S, Kurz C, SAnchez Villagra M. Cranial anatomy of the earliest marsupials and the origin of opossums. PLoS ONE. 2009;4:e8278 pubmed publisher
  6. Simons C, Pheasant M, Makunin I, Mattick J. Transposon-free regions in mammalian genomes. Genome Res. 2006;16:164-72 pubmed
  7. Yokomine T, Hata K, Tsudzuki M, Sasaki H. Evolution of the vertebrate DNMT3 gene family: a possible link between existence of DNMT3L and genomic imprinting. Cytogenet Genome Res. 2006;113:75-80 pubmed
    ..We found that, while opossums had an orthologue for DNMT3L, chickens and fish did not have this gene...
  8. Chan J, Kushwaha R, VandeBerg J, Vandeberg J. Effect of ezetimibe on plasma cholesterol levels, cholesterol absorption, and secretion of biliary cholesterol in laboratory opossums with high and low responses to dietary cholesterol. Metabolism. 2008;57:1645-54 pubmed publisher
    Partially inbred lines of laboratory opossums differ in plasma low-density lipoprotein cholesterol concentration and cholesterol absorption on a high-cholesterol diet...
  9. Duret L, Chureau C, Samain S, Weissenbach J, Avner P. The Xist RNA gene evolved in eutherians by pseudogenization of a protein-coding gene. Science. 2006;312:1653-5 pubmed
    ..This event occurred after the divergence between eutherians and marsupials, which suggests that mechanisms of dosage compensation have evolved independently in both lineages...

More Information

Publications69

  1. Jansa S, Voss R. Adaptive evolution of the venom-targeted vWF protein in opossums that eat pitvipers. PLoS ONE. 2011;6:e20997 pubmed publisher
    ..Here we report such evidence from an unusual predator-prey relationship between opossums (Marsupialia: Didelphidae) and pitvipers (Serpentes: Crotalinae)...
  2. Samollow P. The opossum genome: insights and opportunities from an alternative mammal. Genome Res. 2008;18:1199-215 pubmed publisher
    ..domestica that are expanding its versatility as an experimental system for a broad range of research applications in basic biology and biomedically oriented research...
  3. Sánchez Villagra M, Ladevèze S, Horovitz I, Argot C, Hooker J, Macrini T, et al. Exceptionally preserved North American Paleogene metatherians: adaptations and discovery of a major gap in the opossum fossil record. Biol Lett. 2007;3:318-22 pubmed
    ..with a fossil record extending from the Cretaceous to the Miocene, has traditionally been allied with opossums (Didelphidae) based on fragmentary material, mainly dentitions...
  4. Schmidt D, Wilson M, Ballester B, Schwalie P, Brown G, Marshall A, et al. Five-vertebrate ChIP-seq reveals the evolutionary dynamics of transcription factor binding. Science. 2010;328:1036-40 pubmed publisher
    ..Our results reveal large interspecies differences in transcriptional regulation and provide insight into regulatory evolution. ..
  5. Lanaspa M, Giral H, Breusegem S, Halaihel N, Baile G, Catalán J, et al. Interaction of MAP17 with NHERF3/4 induces translocation of the renal Na/Pi IIa transporter to the trans-Golgi. Am J Physiol Renal Physiol. 2007;292:F230-42 pubmed
    ..Therefore, the interaction between MAP17, NHERF3/4, and NaPiIIa in the TGN could be an important intermediate or alternate path in the internalization of NaPiIIa...
  6. Aloni R, Olender T, Lancet D. Ancient genomic architecture for mammalian olfactory receptor clusters. Genome Biol. 2006;7:R88 pubmed
    ..Whole-genome sequence alignment nets of five mammals allow their comprehensive comparison, aimed at reconstructing the ancestral olfactory subgenome...
  7. Hoppe R, Lambert T, Samollow P, Breer H, Strotmann J. Evolution of the "OR37" subfamily of olfactory receptors: a cross-species comparison. J Mol Evol. 2006;62:460-72 pubmed
    ..Together, these results reveal novel information concerning the phylogenetic origin and important evolutionary steps of the mammalian-specific OR37 olfactory receptor family...
  8. Murphy W, Pringle T, Crider T, Springer M, Miller W. Using genomic data to unravel the root of the placental mammal phylogeny. Genome Res. 2007;17:413-21 pubmed
    ..We discuss the impacts of this topology on earlier phylogenetic reconstructions and repeat-based inferences of phylogeny...
  9. Mikkelsen T, Wakefield M, Aken B, Amemiya C, Chang J, Duke S, et al. Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences. Nature. 2007;447:167-77 pubmed
    ..A substantial proportion of these eutherian-specific CNEs arose from sequence inserted by transposable elements, pointing to transposons as a major creative force in the evolution of mammalian gene regulation...
  10. Civen R, Ngo V. Murine typhus: an unrecognized suburban vectorborne disease. Clin Infect Dis. 2008;46:913-8 pubmed publisher
    ..Contrary to the classic rat-flea-rat cycle, the most important reservoirs of infection in these areas are opossums and cats. The cat flea, Ctenocephalides felis, has been identified as the principal vector...
  11. Vagliasindi L, Arena G, Bonomo R, Pappalardo G, Tabbì G. Copper complex species within a fragment of the N-terminal repeat region in opossum PrP protein. Dalton Trans. 2011;40:2441-50 pubmed publisher
    ..The [Cu(L)H(-2)] species formed by the Ac-PHPGGSNWGQ-NH(2) decapeptide, having a slightly lower stability, turned out to be less abundant and to exist within a narrow pH range...
  12. Chan J, Sharkey F, Kushwaha R, VandeBerg J, Vandeberg J. Steatohepatitis in laboratory opossums exhibiting a high lipemic response to dietary cholesterol and fat. Am J Physiol Gastrointest Liver Physiol. 2012;303:G12-9 pubmed publisher
    Plasma VLDL and LDL cholesterol were markedly elevated (>40-fold) in high-responding opossums, but moderately elevated (6-fold) in low-responding opossums after they had consumed a high-cholesterol and high-fat diet for 24 wk...
  13. Souza R, Soares A, Alves C, Lorosa E, Pereira M, Diotaiuti L. Feeding behavior of Triatoma vitticeps (Reduviidae: Triatominae) in the state of Minas Gerais, Brazil. Mem Inst Oswaldo Cruz. 2011;106:16-22 pubmed
    ..vitticeps under natural conditions, as it was evidenced by the precipitin test...
  14. Rosypal A, Hill R, Lewis S, Barr S, Valadas S, Gennari S, et al. Evaluation of a rapid immunochromatographic dipstick test for detection of antibodies to Trypanosoma cruzi in dogs experimentally infected with isolates obtained from opossums (Didelphis virginiana), armadillos (Dasypus novemcinctus), and dogs (Canis. J Parasitol. 2011;97:140-3 pubmed publisher
    ..Our study indicates that the ICT could be a useful screening tool for serological surveillance of canine T. cruzi exposure in the United States...
  15. Voss R. Opossums (Mammalia: Didelphidae) in the diets of Neotropical pitvipers (Serpentes: Crotalinae): evidence for alternative coevolutionary outcomes?. Toxicon. 2013;66:1-6 pubmed publisher
    b>Opossums and pitvipers are sympatric throughout most of the New World, but trophic relationships between these speciose clades have only recently attracted the attention of researchers...
  16. Chan J, Donalson L, Kushwaha R, Ferdinandusse S, VandeBerg J, Vandeberg J. Differential expression of hepatic genes involved in cholesterol homeostasis in high- and low-responding strains of laboratory opossums. Metabolism. 2008;57:718-24 pubmed publisher
    ..lipoprotein and low-density lipoprotein (VLDL+LDL) cholesterol levels of 2 partially inbred strains of opossums (Monodelphis domestica) differ markedly when they are fed a high-cholesterol and low-fat (HCLF) diet...
  17. Zhang J, Huang G, Halpern M. Firing properties of accessory olfactory bulb mitral/tufted cells in response to urine delivered to the vomeronasal organ of gray short-tailed opossums. Chem Senses. 2007;32:355-60 pubmed
    ..Here we report that mitral/tufted (M/T) cells of the accessory olfactory bulb (AOB) of male opossums responded to female urine but not to male urine with two distinct patterns: excitation followed by inhibition or ..
  18. Steiner C, Tilak M, Douzery E, Catzeflis F. New DNA data from a transthyretin nuclear intron suggest an Oligocene to Miocene diversification of living South America opossums (Marsupialia: Didelphidae). Mol Phylogenet Evol. 2005;35:363-79 pubmed
    ..Nuclear markers supported the monophyly of medium and large-sized opossums Metachirus+(Chironectes, Lutreolina, Didelphis, Philander), and the paraphyly of mouse-sized opossums, with the ..
  19. Villa Bellosta R, Sorribas V. Different effects of arsenate and phosphonoformate on P(i) transport adaptation in opossum kidney cells. Am J Physiol Cell Physiol. 2009;297:C516-25 pubmed publisher
    ..To conclude, a mathematical definition of the adaptation process is reported, thereby explaining the limited changes in P(i) transport V(max)...
  20. Mahon M, Cole J, Lederer E, Segre G. Na+/H+ exchanger-regulatory factor 1 mediates inhibition of phosphate transport by parathyroid hormone and second messengers by acting at multiple sites in opossum kidney cells. Mol Endocrinol. 2003;17:2355-64 pubmed
    ..These pathways may involve cooperativity between cAMP- and protein kinase C-dependent pathways or activation/inhibition of an unrecognized NHERF-1-dependent pathway(s)...
  21. Boostrom A, Beier M, Macaluso J, Macaluso K, Sprenger D, Hayes J, et al. Geographic association of Rickettsia felis-infected opossums with human murine typhus, Texas. Emerg Infect Dis. 2002;8:549-54 pubmed
    ..R. felis has been associated with opossums and their fleas in Texas and California. Because R...
  22. Zhai X, Nielsen R, Birn H, Drumm K, Mildenberger S, Freudinger R, et al. Cubilin- and megalin-mediated uptake of albumin in cultured proximal tubule cells of opossum kidney. Kidney Int. 2000;58:1523-33 pubmed
    ..Two giant glycoproteins, cubilin and megalin, constitute important endocytic receptors localized to the kidney proximal tubule...
  23. Lam M, Belov K, Harrison G, Cooper D. Cloning of the MHC class II DRB cDNA from the brushtail possum (Trichosurus vulpecula). Immunol Lett. 2001;76:31-6 pubmed
    ..The T. vulpecula sequence shared an average overall sequence identity of 75.4% at the deduced amino acid level with M. rufogriseus and M. domestica, respectively...
  24. Uc A, Murray J, Kooy N, Conklin J. Effect of peroxynitrite on motor function of the opossum esophagus. Dig Dis Sci. 2001;46:30-7 pubmed
    ..It is possible that some of the esophageal motor dysfunction seen with esophagitis may be related to the formation of ONOO-...
  25. Tasca T, De Carli G, Glock L, Jeckel Neto E. Morphologic aspects of Tetratrichomonas didelphidis isolated from opossums Didelphis marsupialis and Lutreolina crassicaudata. Mem Inst Oswaldo Cruz. 2001;96:265-71 pubmed
    ..The parasitic protozoa used in this study was found and isolated in the intestine of opossums in Pavlova starch-containing medium in Florianópolis, State of Santa Catarina, Brazil, from D...
  26. Rabinovich J, Schweigmann N, Yohai V, Wisnivesky Colli C. Probability of Trypanosoma cruzi transmission by Triatoma infestans (Hemiptera: Reduviidae) to the opossum Didelphis albiventris (Marsupialia: Didelphidae). Am J Trop Med Hyg. 2001;65:125-30 pubmed
    The probability of Trypanosoma cruzi transmission to opossums by independent events of predation and fecal contamination during feeding ("biting") with positive Triatoma infestans was estimated...
  27. Smith K. Early development of the neural plate, neural crest and facial region of marsupials. J Anat. 2001;199:121-31 pubmed
    ..These observations illustrate how development may be modified to produce evolutionary changes that distinguish taxa. Further, they suggest that development is not necessarily highly conserved, but instead may be quite plastic...
  28. Gustiananda M, Haris P, Milburn P, Gready J. Copper-induced conformational change in a marsupial prion protein repeat peptide probed using FTIR spectroscopy. FEBS Lett. 2002;512:38-42 pubmed
    ..The copper-induced conformational change is pH dependent, and occurs at pH >7...
  29. Ding F, Patel C, Ratnam S, McCarrey J, Chaillet J. Conservation of Dnmt1o cytosine methyltransferase in the marsupial Monodelphis domestica. Genesis. 2003;36:209-13 pubmed
    ..Thus, an essential component of imprinting in eutherian mammals is found in a marsupial species, suggesting that marsupials and eutherian mammals imprint their genes with the same methylation-dependent mechanism...
  30. Ramirez L, Lages Silva E, Alvarenga Franco F, Matos A, Vargas N, Fernandes O, et al. High prevalence of Trypanosoma rangeli and Trypanosoma cruzi in opossums and triatomids in a formerly-endemic area of Chagas disease in Southeast Brazil. Acta Trop. 2002;84:189-98 pubmed
    ..Here we report for the first time a high prevalence of T. rangeli in opossums and triatomids captured in peridomestic environments in a formerly-endemic area of Chagas disease in Southeast ..
  31. Pagnozzi J, Ditchfield A, Yonenaga Yassuda Y. Mapping the distribution of the interstitial telomeric (TTAGGG)n sequences in eight species of Brazilian marsupials (Didelphidae) by FISH and the correlation with constitutive heterochromatin. Do ITS represent evidence for fusion events in American m. Cytogenet Genome Res. 2002;98:278-84 pubmed
    ..We suggest that the interstitial (TTAGGG)(n) sequences are associated with satellite DNA and do not necessarily arise through chromosomal rearrangements...
  32. Weidman J, Murphy S, Nolan C, Dietrich F, Jirtle R. Phylogenetic footprint analysis of IGF2 in extant mammals. Genome Res. 2004;14:1726-32 pubmed publisher
  33. Sidaway J, Davidson R, McTaggart F, Orton T, Scott R, Smith G, et al. Inhibitors of 3-hydroxy-3-methylglutaryl-CoA reductase reduce receptor-mediated endocytosis in opossum kidney cells. J Am Soc Nephrol. 2004;15:2258-65 pubmed
    ..These data establish the possibility in principle that inhibition of HMG-CoA reductase by statins in proximal tubule cells may reduce tubular protein reabsorption...
  34. Mahon M, Segre G. Stimulation by parathyroid hormone of a NHERF-1-assembled complex consisting of the parathyroid hormone I receptor, phospholipase Cbeta, and actin increases intracellular calcium in opossum kidney cells. J Biol Chem. 2004;279:23550-8 pubmed
    ..Thus, NHERF-1 assembles a signaling complex in the apical domains of OK cells that contains the PTH1R, PLCbeta, and the actin cytoskeleton. Disruption of this complex blocks the PTH mediated increases of intracellular calcium...
  35. Rens W, O Brien P, Fairclough H, Harman L, Graves J, Ferguson Smith M. Reversal and convergence in marsupial chromosome evolution. Cytogenet Genome Res. 2003;102:282-90 pubmed
    ..From these and other painting comparisons, we conclude that there have been at least three reversals of fusions by fissions, and at least three fusions or fissions that have occurred independently in different lineages...
  36. Killian J, Byrd J, Jirtle J, Munday B, Stoskopf M, MacDonald R, et al. M6P/IGF2R imprinting evolution in mammals. Mol Cell. 2000;5:707-16 pubmed
    ..Unless there was convergent evolution of M6P/ IGF2R imprinting and receptor IGF2 binding in marsupials and eutherians, our results also demonstrate that these two functions evolved in a mammalian clade exclusive of monotremes...
  37. Park H, Calrk E, Cullen J, Conklin J. Effect of endotoxin on opossum oesophageal motor function. Neurogastroenterol Motil. 2000;12:215-21 pubmed
    ..The increase in plasma nitrite/nitrate was attenuated by AG. These studies support the hypothesis that endotoxin modulates oesophageal motor function by increasing NO production and suggest that this results from the induction of iNOS...
  38. Fadem B. Evidence for extended action of gonadal hormones on the organization of sexually dimorphic behavior and morphology in gray short-tailed opossums (Monodelphis domestica). Horm Behav. 2001;39:113-20 pubmed
    Male and female gray short-tailed opossums were gonadectomized (GDX), or treated with the estrogen receptor antagonist tamoxifen citrate (TX), or corn oil (OIL) (control) during the 5th postnatal week, a time period equivalent to the 3rd ..
  39. Martinez Marcos A, Ubeda Banon I, Halpern M. Cell migration to the anterior and posterior divisions of the granule cell layer of the accessory olfactory bulb of adult opossums. Brain Res Dev Brain Res. 2001;127:95-8 pubmed
    ..One week postinjection, an increase of cells was detected in the granule layer but not in the glomerular or mitral/tufted cell layers. No evidence for differential addition of cells to the anterior and posterior divisions was observed...
  40. Kollars T, Kengluecha A. Spotted fever group Rickettsia in Dermacentor variabilis (Acari: Ixodidae) infesting raccoons (Carnivora: Procyonidae) and opossums (Marsupialia: Didelphimorphidae) in Tennessee. J Med Entomol. 2001;38:601-2 pubmed
    ..1%) of adult Dermacentor variabilis Say removed from raccoons (Procyon lotor L.) and Virginia opossums (Didelphis virginiana Kerr) in western Tennessee...
  41. Diegel K, Fitzgerald S, Berry D, Church S, Reed W, Sikarskie J, et al. Experimental inoculation of North American opossums (Didelphis virginiana) with Mycobacterium bovis. J Wildl Dis. 2002;38:275-81 pubmed
    Eight North American opossums (Didelphis virginiana) were inoculated with 1 x 10(5) colony forming units of Mycobacterium bovis to investigate their potential as reservoir hosts for bovine tuberculosis in Michigan...
  42. Fuster D, Moe O, Hilgemann D. Lipid- and mechanosensitivities of sodium/hydrogen exchangers analyzed by electrical methods. Proc Natl Acad Sci U S A. 2004;101:10482-7 pubmed
    ..Expressed in AP-1 cells, however, NHE1 is insensitive to these agents but remains sensitive to volume changes. Thus, changes of hydrophobic mismatch can modulate NHE1 but do not underlie its volume sensitivity...
  43. Kushwaha R, VandeBerg J, Rodriguez R, Vandeberg J. Cholesterol absorption and hepatic acyl-coenzyme A:cholesterol acyltransferase activity play major roles in lipemic response to dietary cholesterol and fat in laboratory opossums. Metabolism. 2004;53:817-22 pubmed
    Partially inbred lines of laboratory opossums differ considerably in their low-density lipoprotein (LDL) cholesterol responses to dietary cholesterol and fat...
  44. Fitzgerald S, Zwick L, Diegel K, Berry D, Church S, Sikarskie J, et al. Experimental aerosol inoculation of Mycobacterium bovis in North American opossums (Didelphis virginiana). J Wildl Dis. 2003;39:418-23 pubmed
    The goal of this study was to evaluate the susceptibility of North American opossums (Didelphis virginiana) to aerosol inoculation of Mycobacterium bovis at two dose levels in order to gain information on disease pathogenesis, fecal ..
  45. Fry E, Stolp H, Lane M, Dziegielewska K, Saunders N. Regeneration of supraspinal axons after complete transection of the thoracic spinal cord in neonatal opossums (Monodelphis domestica). J Comp Neurol. 2003;466:422-44 pubmed
  46. Bertrand D, Lajoie M, El Mabrouk N. Inferring ancestral gene orders for a family of tandemly arrayed genes. J Comput Biol. 2008;15:1063-77 pubmed publisher
    ..An application on a cluster of olfactory receptor genes in four mammals is presented. ..
  47. Kutter C, Brown G, Goncalves A, Wilson M, Watt S, Brazma A, et al. Pol III binding in six mammals shows conservation among amino acid isotypes despite divergence among tRNA genes. Nat Genet. 2011;43:948-55 pubmed publisher
    ..Thus, synthesis of functional tRNA isotypes has been highly constrained, although the usage of individual tRNA genes has evolved rapidly. ..
  48. Torres Montoya E, Zazueta Moreno J, Osuna Martínez L, Castillo Ureta H, Silva Hidalgo G, López Moreno H, et al. Histopathological changes in the liver and stomach of Didelphis virginiana (Didelphimorphia: Didelphidae) during natural infection with Gnathostoma turgidum (Nematoda: Gnathostomidae). J Helminthol. 2017;:1-4 pubmed publisher
    Gnathostoma turgidum is a nematode parasite that exploits the stomach of Virginian opossums, Didelphis virginiana, in Latin America. The opossum is the definitive host of G. turgidum in the wild...
  49. D Andrea P, Gentile R, Maroja L, Fernandes F, Coura R, Cerqueira R. Small mammal populations of an agroecosystem in the Atlantic Forest domain, southeastern Brazil. Braz J Biol. 2007;67:179-86 pubmed
    ..Rodent populations were more susceptible to the removal procedure than marsupial ones. ..
  50. Morton R, Lord W. Taphonomy of child-sized remains: a study of scattering and scavenging in Virginia, USA. J Forensic Sci. 2006;51:475-9 pubmed
    ..Alternately, carrion-frequenting insects were afforded access to previously inaccessible colonization sites as a result of scavenging vertebrate activities...
  51. Preuschoft H, Witzel U. Functional shape of the skull in vertebrates: which forces determine skull morphology in lower primates and ancestral synapsids?. Anat Rec A Discov Mol Cell Evol Biol. 2005;283:402-13 pubmed
    ..This study demonstrates the utility of finite-element modeling for testing hypotheses regarding relationships between form and function in vertebrate skulls. ..
  52. Jiménez F, Gardner S, Navone G, Orti G. Four events of host switching in Aspidoderidae (Nematoda) involve convergent lineages of mammals. J Parasitol. 2012;98:1166-75 pubmed publisher
    ..e., dasypodids, opossums, and sigmodontine, geomyid, and hystricognath rodents...
  53. Young L, Harrison G. Molecular characterization of interleukin-1Beta in the tammar wallaby (Macropus eugenii). J Vet Med Sci. 2010;72:1521-6 pubmed
    ..Molecular characterization of tammar wallaby IL-1? provides fundamental information necessary to progress the study of functional immune responses in this unique group of mammals...
  54. Okada S, Schraufnagel D. Scanning electron microscopic structure of the lingual papillae of the common opossum (Didelphis marsupialis). Microsc Microanal. 2005;11:319-32 pubmed
    ..These findings and the structure of the rest of the masticatory apparatus suggest the lingual papillae of opossum have kept their ancestral carnivorous features but also developed the herbivore characteristics of other marsupials...
  55. Jaumouillé V, Krishnan D, Alexander R. The calmodulin antagonist W-7 inhibits the epithelial Na+/H+ exchanger via modulating membrane surface potential. Channels (Austin). 2011;5:308-13 pubmed publisher
    ..We propose therefore that W-7 inhibits NHE3 activity, at least in part, by altering the association of cationic segments within the carboxy-terminus of the exchanger with anionic phospholipids in the plasma membrane...
  56. Flicek P, Brent M. Using several pair-wise informant sequences for de novo prediction of alternatively spliced transcripts. Genome Biol. 2006;7 Suppl 1:S8.1-9 pubmed
    ..MARS is able to use an arbitrary number of informant sequences and predicts a number of alternative transcripts at each gene locus...
  57. Dogan I, Bhargava V, Liu J, Mittal R. Axial stretch: A novel mechanism of the lower esophageal sphincter relaxation. Am J Physiol Gastrointest Liver Physiol. 2007;292:G329-34 pubmed
    ..In adult opossums, a silicon tube was placed via mouth into the esophagus and laparotomy was performed...
  58. Chu T, Wu M, Wu K, Hsieh B. Endothelin-1 activates MAPKs and modulates cell cycle proteins in OKP cells. J Formos Med Assoc. 2007;106:273-80 pubmed
    ..The signaling mechanisms through which endothelin (ET)-1 induces hyperplasia of the renal tubular epithelium are largely unknown...
  59. Deakin J, Delbridge M, Koina E, Harley N, Alsop A, Wang C, et al. Reconstruction of the ancestral marsupial karyotype from comparative gene maps. BMC Evol Biol. 2013;13:258 pubmed publisher
  60. Gibbons C, Maldonado Pérez D, Shah A, Riccardi D, Ward D. Calcium-sensing receptor antagonism or lithium treatment ameliorates aminoglycoside-induced cell death in renal epithelial cells. Biochim Biophys Acta. 2008;1782:188-95 pubmed publisher
    ..Together, these data implicate CaR activation and a lithium-inhibitable signalling pathway in the induction of cell death by gentamicin in renal epithelial cells in culture...