macropodidae

Summary

Summary: A family of herbivorous leaping MAMMALS of Australia, New Guinea, and adjacent islands. Members include kangaroos, wallabies, quokkas, and wallaroos.

Top Publications

  1. Yu H, Pask A, Shaw G, Renfree M. Comparative analysis of the mammalian WNT4 promoter. BMC Genomics. 2009;10:416 pubmed publisher
    ..These transcription factor binding sites and CpG islands are highly conserved in two disparate mammals, and are likely key controlling elements in the regulation of this essential developmental gene. ..
  2. Park D, Pask A, Huynh K, Harley V, Renfree M, Graves J. Characterisation of the marsupial-specific ATRY gene: implications for the evolution of male-specific function. Gene. 2005;362:29-36 pubmed
    ..The conservation and loss of particular motifs identify those required for testicular function (ATRY) and function in other tissues (ATRX). ..
  3. Smits G, Mungall A, Griffiths Jones S, Smith P, Beury D, Matthews L, et al. Conservation of the H19 noncoding RNA and H19-IGF2 imprinting mechanism in therians. Nat Genet. 2008;40:971-6 pubmed publisher
    ..The conservation in all therians of the mechanism controlling imprinting of the IGF2-H19 locus suggests a sequential model of imprinting evolution. ..
  4. Chhour K, Hinds L, Jacques N, Deane E. An observational study of the microbiome of the maternal pouch and saliva of the tammar wallaby, Macropus eugenii, and of the gastrointestinal tract of the pouch young. Microbiology. 2010;156:798-808 pubmed publisher
    ..Overall, the majority of bacteria isolated were novel species (<97 % identity to known 16S rDNA sequences), and each study site (i.e. maternal pouch and saliva, and the GIT of the pouch young) possessed its own unique microbiome. ..
  5. Menzies B, Shaw G, Fletcher T, Pask A, Renfree M. Exon 3 of the growth hormone receptor (GH-R) is specific to eutherian mammals. Mol Cell Endocrinol. 2008;296:64-8 pubmed publisher
    ..These data show that exon 3 was inserted into the GH-R after the divergence of the marsupial and eutherian lineages at least 130 million years ago. ..
  6. Hickford D, Shaw G, Renfree M. In vitro culture of peri-gastrulation embryos of a macropodid marsupial. J Anat. 2008;212:180-91 pubmed
    ..These results provide a basis for developing culture conditions for longer term development of marsupial embryos in vitro. ..
  7. Renfree M, Papenfuss A, Deakin J, Lindsay J, Heider T, Belov K, et al. Genome sequence of an Australian kangaroo, Macropus eugenii, provides insight into the evolution of mammalian reproduction and development. Genome Biol. 2011;12:R81 pubmed publisher
  8. Ager E, Pask A, Gehring H, Shaw G, Renfree M. Evolution of the CDKN1C-KCNQ1 imprinted domain. BMC Evol Biol. 2008;8:163 pubmed publisher
    ..These findings demonstrate the stepwise accumulation of control mechanisms within imprinted domains and show that CDKN1C imprinting cannot be due to its synteny with IGF2 or with its placental expression in mammals. ..
  9. Calatayud N, Pask A, Shaw G, Richings N, Osborn S, Renfree M. Ontogeny of the oestrogen receptors ESR1 and ESR2 during gonadal development in the tammar wallaby, Macropus eugenii. Reproduction. 2010;139:599-611 pubmed publisher
    ..The receptors can respond to exogenous estrogen at this early stage and are capable of transducing signals in the early mammalian gonad. However, the selective forces that maintained conserved ER expression in this tissue remain unknown...

More Information

Publications71

  1. Sanderson C, Belov K, Deakin J. Physical mapping of immune genes in the tammar wallaby (Macropus eugenii). Cytogenet Genome Res. 2009;127:21-5 pubmed publisher
    ..The isolation and mapping of these key immune genes in the tammar wallaby will aid in the assembly of the recently sequenced light coverage genome and assignment of sequence to chromosomes...
  2. Yu H, Lindsay J, Feng Z, Frankenberg S, Hu Y, Carone D, et al. Evolution of coding and non-coding genes in HOX clusters of a marsupial. BMC Genomics. 2012;13:251 pubmed publisher
    ..The sequencing of the kangaroo genome provides an opportunity to use comparative analyses to compare the HOX clusters of a mammal with a distinct body plan to those of other mammals...
  3. Topcic D, Auguste A, De Leo A, Lefevre C, Digby M, Nicholas K. Characterization of the tammar wallaby (Macropus eugenii) whey acidic protein gene: new insights into the function of the protein. Evol Dev. 2009;11:363-75 pubmed publisher
  4. Gagen E, Denman S, Padmanabha J, Zadbuke S, Al Jassim R, Morrison M, et al. Functional gene analysis suggests different acetogen populations in the bovine rumen and tammar wallaby forestomach. Appl Environ Microbiol. 2010;76:7785-95 pubmed publisher
    ..The community structures of the acsB and fhs libraries from the rumen and the tammar wallaby forestomach were different (LIBSHUFF, P < 0.001), and these differences may have significance for overall hydrogenotrophy in both ecosystems...
  5. Warburton N, Harvey K, Prideaux G, O Shea J. Functional morphology of the forelimb of living and extinct tree-kangaroos (Marsupialia: Macropodidae). J Morphol. 2011;272:1230-44 pubmed publisher
    ..Despite the irony of their retrieval from deposits of the Nullarbor "Treeless" Plain, forelimb morphology clearly shows that the species of Bohra were well adapted to an arboreal habitat...
  6. Sankovic N, Delbridge M, Grutzner F, Ferguson Smith M, O Brien P, Marshall Graves J. Construction of a highly enriched marsupial Y chromosome-specific BAC sub-library using isolated Y chromosomes. Chromosome Res. 2006;14:657-64 pubmed
    ..This presents an ideal method for the creation of highly enriched chromosome-specific sub-libraries suitable for BAC-based sequencing of the Y chromosome of any mammalian species...
  7. Ferreri G, Marzelli M, Rens W, O Neill R. A centromere-specific retroviral element associated with breaks of synteny in macropodine marsupials. Cytogenet Genome Res. 2004;107:115-8 pubmed
    ..Marsupials of the family Macropodidae (kangaroos, wallabies, rat kangaroos and potoroos) offer unique insights into current theories expositing ..
  8. Wang J, Wong E, Whitley J, Li J, Stringer J, Short K, et al. Ancient antimicrobial peptides kill antibiotic-resistant pathogens: Australian mammals provide new options. PLoS ONE. 2011;6:e24030 pubmed publisher
    ..In this study we focus on the cathelicidins, a key family of antimicrobial peptide genes...
  9. Bulazel K, Metcalfe C, Ferreri G, Yu J, Eldridge M, O Neill R. Cytogenetic and molecular evaluation of centromere-associated DNA sequences from a marsupial (Macropodidae: Macropus rufogriseus) X chromosome. Genetics. 2006;172:1129-37 pubmed
    ..of the centromeric portions of the sex chromosomes of the red-necked wallaby, Macropus rufogriseus (family Macropodidae, subfamily Macropodinae), was investigated to develop an overview of the sequence composition of centromeres in ..
  10. Yu H, Pask A, Shaw G, Renfree M. Differential expression of WNT4 in testicular and ovarian development in a marsupial. BMC Dev Biol. 2006;6:44 pubmed
  11. Siddle H, Deakin J, Coggill P, Hart E, Cheng Y, Wong E, et al. MHC-linked and un-linked class I genes in the wallaby. BMC Genomics. 2009;10:310 pubmed publisher
    ..The discovery of non-classical orthologs between distantly related marsupial species is unusual for the rapidly evolving class I genes and may indicate an important marsupial specific function. ..
  12. Joss J, Molloy M, Hinds L, Deane E. A longitudinal study of the protein components of marsupial milk from birth to weaning in the tammar wallaby (Macropus eugenii). Dev Comp Immunol. 2009;33:152-61 pubmed publisher
  13. Leihy M, Shaw G, Wilson J, Renfree M. Penile development is initiated in the tammar wallaby pouch young during the period when 5alpha-androstane-3alpha,17beta-diol is secreted by the testes. Endocrinology. 2004;145:3346-52 pubmed
  14. Wang C, Webley L, Wei K, Wakefield M, Patel H, Deakin J, et al. A second-generation anchored genetic linkage map of the tammar wallaby (Macropus eugenii). BMC Genet. 2011;12:72 pubmed publisher
    ..It has great value as a resource to identify novel genes and for comparative studies, and is vital for the ongoing genome sequence assembly and gene ordering in this species...
  15. Lefèvre C, Digby M, Whitley J, Strahm Y, Nicholas K. Lactation transcriptomics in the Australian marsupial, Macropus eugenii: transcript sequencing and quantification. BMC Genomics. 2007;8:417 pubmed
    ..Marsupials, such as the tammar wallaby (Macropus eugenii) give birth to a relatively immature newborn and progressive changes in milk composition and milk production regulate early stage development of the young...
  16. Cross J, Harrison G, Coggill P, Sims S, Beck S, Deakin J, et al. Analysis of the genomic region containing the tammar wallaby (Macropus eugenii) orthologues of MHC class III genes. Cytogenet Genome Res. 2005;111:110-7 pubmed
    ..Full length sequencing of BACs containing the three genes has been partially completed, and reveals the presence of a number of other tammar MHC III orthologues in this region...
  17. Wanyonyi S, Sharp J, Khalil E, Lefevre C, Nicholas K. Tammar wallaby mammary cathelicidins are differentially expressed during lactation and exhibit antimicrobial and cell proliferative activity. Comp Biochem Physiol A Mol Integr Physiol. 2011;160:431-9 pubmed publisher
    ..The study has shown for the first time that temporal regulation of milk cathelicidins may be crucial in antimicrobial protection of the mammary gland and suckled young and mammary cell proliferation...
  18. Nilsson M, Churakov G, Sommer M, Tran N, Zemann A, BROSIUS J, et al. Tracking marsupial evolution using archaic genomic retroposon insertions. PLoS Biol. 2010;8:e1000436 pubmed publisher
    ..The now firmly established phylogeny can be used to determine the direction of genomic changes and morphological transitions within marsupials...
  19. Barnes T, Morton J, Coleman G. Clustering of hydatid infection in macropodids. Int J Parasitol. 2007;37:943-52 pubmed
    ..They also demonstrate that spatial clustering should be considered when analysing hydatid infection data in macropodids, particularly when assessing area-level risk factors...
  20. Deakin J, Siddle H, Cross J, Belov K, Graves J. Class I genes have split from the MHC in the tammar wallaby. Cytogenet Genome Res. 2007;116:205-11 pubmed
    ..It highlights the need for the inclusion of more than one marsupial species in comparative studies and raises questions regarding the functional significance of the clustering of MHC genes...
  21. Freyer C, Zeller U, Renfree M. Placental function in two distantly related marsupials. Placenta. 2007;28:249-57 pubmed
  22. Wong E, Papenfuss A, Heger A, Hsu A, Ponting C, Miller R, et al. Transcriptomic analysis supports similar functional roles for the two thymuses of the tammar wallaby. BMC Genomics. 2011;12:420 pubmed publisher
    ..Here, we used pyrosequencing to compare the transcriptomes of a cervical and thoracic thymus from a single 178 day old tammar wallaby...
  23. Hu Y, Yu H, Shaw G, Pask A, Renfree M. Kallmann syndrome 1 gene is expressed in the marsupial gonad. Biol Reprod. 2011;84:595-603 pubmed publisher
    ..Because KAL1 is autosomal in marsupials but is X-linked in eutherians, its conserved involvement in gametogenesis supports the hypothesis that reproduction-related genes were actively recruited to the eutherian X chromosome...
  24. Ferreri G, Brown J, Obergfell C, Jue N, Finn C, O Neill M, et al. Recent amplification of the kangaroo endogenous retrovirus, KERV, limited to the centromere. J Virol. 2011;85:4761-71 pubmed publisher
    ..rufogriseus is likely due to duplications and concerted evolution rather than a high number of independent insertion events...
  25. Madsen J, Bertelsen M. Methane production by red-necked wallabies (Macropus rufogriseus). J Anim Sci. 2012;90:1364-70 pubmed publisher
    ..It was found that the CH(4)/CO(2) ratio in itself represents a reasonable prediction of the proportion of feed GE that is lost as CH(4), and that this method offers new opportunities for CH(4) measurements on a large number of animals...
  26. Huyhn K, Renfree M, Graves J, Pask A. ATRX has a critical and conserved role in mammalian sexual differentiation. BMC Dev Biol. 2011;11:39 pubmed publisher
    ..The disease is characterised by severe mental retardation, mild alpha-thalassemia, microcephaly, short stature, facial, skeletal, genital and gonadal abnormalities...
  27. Menzies B, Shaw G, Fletcher T, Renfree M. Early onset of ghrelin production in a marsupial. Mol Cell Endocrinol. 2009;299:266-73 pubmed publisher
    ..These results demonstrate an early onset of gastric ghrelin expression in the tammar in concert with a functional stomach at a relatively earlier stage than that of developmentally more mature eutherian young...
  28. Park D, Pask A, Huynh K, Renfree M, Harley V, Graves J. Comparative analysis of ATRX, a chromatin remodeling protein. Gene. 2004;339:39-48 pubmed
    ..Alignment of vertebrate ATRX sequences highlights other conserved elements, including a negatively charged mammalian sequence which we propose to be involved in binding of positively charged histone tails...
  29. Ouwerkerk D, Klieve A, Forster R, Templeton J, Maguire A. Characterization of culturable anaerobic bacteria from the forestomach of an eastern grey kangaroo, Macropus giganteus. Lett Appl Microbiol. 2005;41:327-33 pubmed
    ..To determine the culturable biodiversity of anaerobic bacteria isolated from the forestomach contents of an eastern grey kangaroo, Macropus giganteus, using phenotypic characterization and 16S rDNA sequence analysis...
  30. Deakin J, Koina E, Waters P, Doherty R, Patel V, Delbridge M, et al. Physical map of two tammar wallaby chromosomes: a strategy for mapping in non-model mammals. Chromosome Res. 2008;16:1159-75 pubmed publisher
    ..Frequent rearrangement of the X, along with the absence of a marsupial XIST gene, suggests that inactivation of the marsupial X chromosome does not depend on a whole-chromosome repression by a control locus...
  31. Siddle H, Deakin J, Baker M, Miller R, Belov K. Isolation of major histocompatibility complex Class I genes from the tammar wallaby (Macropus eugenii). Immunogenetics. 2006;58:487-93 pubmed
    ..Phylogenetic analysis of tammar wallaby Class I sequences and other mammalian Class I sequences suggests that some tammar wallaby and red-necked wallaby loci evolved from common ancestral genes...
  32. Deakin J, Papenfuss A, Belov K, Cross J, Coggill P, Palmer S, et al. Evolution and comparative analysis of the MHC Class III inflammatory region. BMC Genomics. 2006;7:281 pubmed
    ..We also discuss the extent of sequence conservation across the entire region and identify elements conserved in evolution...
  33. Brennan A, Sharp J, Digby M, Nicholas K. The tammar wallaby: a model to examine endocrine and local control of lactation. IUBMB Life. 2007;59:146-50 pubmed
  34. Daly K, Digby M, Lefevre C, Nicholas K, Deane E, Williamson P. Identification, characterization and expression of cathelicidin in the pouch young of tammar wallaby (Macropus eugenii). Comp Biochem Physiol B Biochem Mol Biol. 2008;149:524-33 pubmed publisher
    ..Such expression of antimicrobial peptides may form part of the immune strategies of marsupials for neonatal survival during their post-partum development...
  35. Makanya A, Tschanz S, Haenni B, Burri P. Functional respiratory morphology in the newborn quokka wallaby (Setonix brachyurus). J Anat. 2007;211:26-36 pubmed
    ..Qualitatively, the neonate quokka lung had the basic constituents for gas exchange but was quantitatively inadequate, implying the significance of percutaneous gas exchange...
  36. Phillips M, Pratt R. Family-level relationships among the Australasian marsupial "herbivores" (Diprotodontia: Koala, wombats, kangaroos and possums). Mol Phylogenet Evol. 2008;46:594-605 pubmed
    ..The topology resolved reveals ecological niche structuring among diprotodontians that has likely been maintained for more than 40 million years...
  37. Cheng Y, Siddle H, Beck S, Eldridge M, Belov K. High levels of genetic variation at MHC class II DBB loci in the tammar wallaby (Macropus eugenii). Immunogenetics. 2009;61:111-8 pubmed publisher
  38. Chew K, Yu H, Pask A, Shaw G, Renfree M. HOXA13 and HOXD13 expression during development of the syndactylous digits in the marsupial Macropus eugenii. BMC Dev Biol. 2012;12:2 pubmed publisher
    ..We investigated the expression of two genes, HOXA13 and HOXD13, that are crucial for digit patterning in mice during formation of the limbs of the tammar wallaby...
  39. Siddle H, Deakin J, Coggill P, Whilming L, Harrow J, Kaufman J, et al. The tammar wallaby major histocompatibility complex shows evidence of past genomic instability. BMC Genomics. 2011;12:421 pubmed publisher
    ..The duplication of TAP genes in the wallaby MHC makes this species a unique model organism for studying the relationship between MHC gene organization and function...
  40. Bulazel K, Ferreri G, Eldridge M, O Neill R. Species-specific shifts in centromere sequence composition are coincident with breakpoint reuse in karyotypically divergent lineages. Genome Biol. 2007;8:R170 pubmed
  41. Pope P, Denman S, Jones M, Tringe S, Barry K, Malfatti S, et al. Adaptation to herbivory by the Tammar wallaby includes bacterial and glycoside hydrolase profiles different from other herbivores. Proc Natl Acad Sci U S A. 2010;107:14793-8 pubmed publisher
  42. Edwards C, Rens W, Clarke O, Mungall A, Hore T, Graves J, et al. The evolution of imprinting: chromosomal mapping of orthologues of mammalian imprinted domains in monotreme and marsupial mammals. BMC Evol Biol. 2007;7:157 pubmed
    ..There are several theories to account for how the mechanism evolved including the hypothesis that it was driven by the evolution of X-inactivation, or that it arose from an ancestrally imprinted chromosome...
  43. Frankenberg S, Pask A, Renfree M. The evolution of class V POU domain transcription factors in vertebrates and their characterisation in a marsupial. Dev Biol. 2010;337:162-70 pubmed publisher
    ..Thus, unlike POU5F1, the role of POU2 may not be restricted to pluripotent cell types but could have a related function such as maintaining multipotency in adult stem cells...
  44. Fournier P, Taylor C, Rolain J, Barrassi L, Smith G, Raoult D. Bartonella australis sp. nov. from kangaroos, Australia. Emerg Infect Dis. 2007;13:1961-2 pubmed publisher
  45. Schneider N, Fletcher T, Shaw G, Renfree M. The olfactory system of the tammar wallaby is developed at birth and directs the neonate to its mother's pouch odours. Reproduction. 2009;138:849-57 pubmed publisher
    ..We conclude that both olfactory systems are capable of receiving odour signals at birth, a function that must be a critical adaptation for the survival of an altricial marsupial neonate such as the tammar for its journey to the pouch...
  46. Hu Y, Yu H, Pask A, O Brien D, Shaw G, Renfree M. A-kinase anchoring protein 4 has a conserved role in mammalian spermatogenesis. Reproduction. 2009;137:645-53 pubmed publisher
    ..This is consistent with its expression in other mammals. Thus, AKAP4 appears to have a conserved role in spermatogenesis for at least the last 166 million years of mammalian evolution...
  47. Browning T, Belov K, Miller R, Eldridge M. Molecular cloning and characterization of the polymorphic MHC class II DBB from the tammar wallaby (Macropus eugenii). Immunogenetics. 2004;55:791-5 pubmed
    ..Two additional DBB sequences were amplified from tammar wallaby genomic DNA. All four sequences were obtained from the same individual, indicating that there are at least two DBB loci in the tammar wallaby...
  48. Rens W, O Brien P, Fairclough H, Harman L, Graves J, Ferguson Smith M. Reversal and convergence in marsupial chromosome evolution. Cytogenet Genome Res. 2003;102:282-90 pubmed
    ..From these and other painting comparisons, we conclude that there have been at least three reversals of fusions by fissions, and at least three fusions or fissions that have occurred independently in different lineages...
  49. Parsons M, Blumstein D. Familiarity breeds contempt: kangaroos persistently avoid areas with experimentally deployed dingo scents. PLoS ONE. 2010;5:e10403 pubmed publisher
  50. Metcalfe C, Eldridge M, Johnston P. Mapping the distribution of the telomeric sequence (T2AG3)n in the 2n = 14 ancestral marsupial complement and in the macropodines (Marsupialia: Macropodidae) by fluorescence in situ hybridization. Chromosome Res. 2004;12:405-14 pubmed
    ..The presence of centromeric heterochromatin in all Australian 2n = 14 complements therefore suggests that centromeric sites of the (T(2)AG(3))(n) sequence do not represent evidence for recent rearrangements...
  51. Carman R, Old J, Baker M, Jacques N, Deane E. Identification and expression of a novel marsupial cathelicidin from the tammar wallaby (Macropus eugenii). Vet Immunol Immunopathol. 2009;127:269-76 pubmed publisher
  52. Menzies B, Shaw G, Fletcher T, Pask A, Renfree M. Maturation of the growth axis in marsupials occurs gradually during post-natal life and over an equivalent developmental stage relative to eutherian species. Mol Cell Endocrinol. 2012;349:189-94 pubmed publisher
    ..This suggests that the timing of GH-regulated growth in marsupials is not related to parturition but instead to the relative developmental stage...
  53. El Mogharbel N, Deakin J, Tsend Ayush E, Pask A, Graves J. Assignment of the DMRT1 gene to tammar wallaby chromosome 3p by fluorescence in situ hybridization. Cytogenet Genome Res. 2005;108:362 pubmed
  54. Suzuki S, Renfree M, Pask A, Shaw G, Kobayashi S, Kohda T, et al. Genomic imprinting of IGF2, p57(KIP2) and PEG1/MEST in a marsupial, the tammar wallaby. Mech Dev. 2005;122:213-22 pubmed
    ..These data confirm the existence of common imprinted regions in eutherians and marsupials during development, but suggest that the regulatory mechanisms that control imprinted gene expression differ between these two groups of mammals...
  55. Kwek J, Iongh R, Digby M, Renfree M, Nicholas K, Familari M. Cross-fostering of the tammar wallaby (Macropus eugenii) pouch young accelerates fore-stomach maturation. Mech Dev. 2009;126:449-63 pubmed publisher
    ..We propose that milk from later stages of lactation and/or herbage consumed by the PY may play independent roles in regulating these two processes...
  56. Suzuki S, Shaw G, Kaneko ishino T, Ishino F, Renfree M. Characterisation of marsupial PHLDA2 reveals eutherian specific acquisition of imprinting. BMC Evol Biol. 2011;11:244 pubmed publisher
    ..In mice, Phlda2 is a dose-sensitive negative regulator of placental growth, as Cdkn1c is for embryonic growth...
  57. Alsop A, Miethke P, Rofe R, Koina E, Sankovic N, Deakin J, et al. Characterizing the chromosomes of the Australian model marsupial Macropus eugenii (tammar wallaby). Chromosome Res. 2005;13:627-36 pubmed
  58. Cripps J, Wilson M, Elgar M, Coulson G. Experimental manipulation of fertility reveals potential lactation costs in a free-ranging marsupial. Biol Lett. 2011;7:859-62 pubmed publisher
  59. Suzuki S, Ono R, Narita T, Pask A, Shaw G, Wang C, et al. Retrotransposon silencing by DNA methylation can drive mammalian genomic imprinting. PLoS Genet. 2007;3:e55 pubmed
  60. Al Nadaf S, Waters P, Koina E, Deakin J, Jordan K, Graves J. Activity map of the tammar X chromosome shows that marsupial X inactivation is incomplete and escape is stochastic. Genome Biol. 2010;11:R122 pubmed publisher
    ..In marsupials, X inactivation is known to be paternal, incomplete and tissue-specific, and occurs in the absence of an XIST orthologue...
  61. Hickford D, Frankenberg S, Pask A, Shaw G, Renfree M. DDX4 (VASA) is conserved in germ cell development in marsupials and monotremes. Biol Reprod. 2011;85:733-43 pubmed publisher
    ..Collectively these data suggest that DDX4 is essential for the regulation of germ cell proliferation and differentiation across all three extant mammalian groups-eutherians, marsupials, and monotremes...
  62. Neaves L, Zenger K, Cooper D, Eldridge M. Molecular detection of hybridization between sympatric kangaroo species in south-eastern Australia. Heredity (Edinb). 2010;104:502-12 pubmed publisher
    ..Such rare hybridization events allow populations to incorporate novel diversity while still retaining species integrity...