zucker rats

Summary

Summary: Two populations of Zucker rats have been cited in research--the "fatty" or obese and the lean. The "fatty" rat (Rattus norvegicus) appeared as a spontaneous mutant. The obese condition appears to be due to a single recessive gene.

Top Publications

  1. van den Brom C, Bosmans J, Vlasblom R, Handoko L, Huisman M, Lubberink M, et al. Diabetic cardiomyopathy in Zucker diabetic fatty rats: the forgotten right ventricle. Cardiovasc Diabetol. 2010;9:25 pubmed publisher
    ..The purpose of the present study was to investigate whether LV changes are paralleled by RV alterations in a rat model of diabetes...
  2. Flamment M, Arvier M, Gallois Y, Simard G, Malthiery Y, Ritz P, et al. Fatty liver and insulin resistance in obese Zucker rats: no role for mitochondrial dysfunction. Biochimie. 2008;90:1407-13 pubmed publisher
    ..mitochondrial function in fatty liver and insulin resistance state using isolated mitochondria from obese Zucker rats. We determined the relationship between ATP synthesis and oxygen consumption as well as the relationship ..
  3. Peterson J, Bryner R, Alway S. Satellite cell proliferation is reduced in muscles of obese Zucker rats but restored with loading. Am J Physiol Cell Physiol. 2008;295:C521-8 pubmed publisher
  4. Koch T, Briviba K, Watzl B, Bub A, Barth S. Obesity-related promotion of aberrant crypt foci in DMH-treated obese Zucker rats correlates with dyslipidemia rather than hyperinsulinemia. Eur J Nutr. 2008;47:161-70 pubmed publisher
    ..Obesity and energy restriction modulate the development of precancerous aberrant crypt foci (ACF) in animal models of colon cancer...
  5. De Feyter H, Lenaers E, Houten S, Schrauwen P, Hesselink M, Wanders R, et al. Increased intramyocellular lipid content but normal skeletal muscle mitochondrial oxidative capacity throughout the pathogenesis of type 2 diabetes. FASEB J. 2008;22:3947-55 pubmed publisher
    ..Accordingly, we can conclude that in the ZDF rat model, type 2 diabetes develops in the absence of skeletal muscle mitochondrial dysfunction...
  6. Mingorance C, Gonzalez del Pozo M, Dolores Herrera M, Alvarez de Sotomayor M. Oral supplementation of propionyl-l-carnitine reduces body weight and hyperinsulinaemia in obese Zucker rats. Br J Nutr. 2009;102:1145-53 pubmed publisher
    ..on an animal model of obesity, insulin resistance and, consequently, endothelial dysfunction, lean and obese Zucker rats (OZR) received either vehicle- or PLC-supplemented drinking water (200 mg/kg per d) for 20 weeks...
  7. Goodwill A, James M, Frisbee J. Increased vascular thromboxane generation impairs dilation of skeletal muscle arterioles of obese Zucker rats with reduced oxygen tension. Am J Physiol Heart Circ Physiol. 2008;295:H1522-8 pubmed publisher
    ..with reduced Po(2) contributes to impaired hypoxic dilation of skeletal muscle resistance arterioles of obese Zucker rats (OZRs) versus lean Zucker rats (LZRs)...
  8. Madala Halagappa V, Tiwari S, Riazi S, Hu X, Ecelbarger C. Chronic candesartan alters expression and activity of NKCC2, NCC, and ENaC in the obese Zucker rat. Am J Physiol Renal Physiol. 2008;294:F1222-31 pubmed publisher
    ..lean Zucker rats. Male obese and lean Zucker rats (10-wk old) were fed either 1) control chow (1% NaCl) or 2) chow with ..
  9. Zhao X, Li L. PPAR-alpha agonist fenofibrate induces renal CYP enzymes and reduces blood pressure and glomerular hypertrophy in Zucker diabetic fatty rats. Am J Nephrol. 2008;28:598-606 pubmed publisher
  10. Rivera L, Morón R, Sanchez M, Zarzuelo A, Galisteo M. Quercetin ameliorates metabolic syndrome and improves the inflammatory status in obese Zucker rats. Obesity (Silver Spring). 2008;16:2081-7 pubmed publisher
    ..For this purpose, obese Zucker rats and their lean littermates were used...

Detail Information

Publications62

  1. van den Brom C, Bosmans J, Vlasblom R, Handoko L, Huisman M, Lubberink M, et al. Diabetic cardiomyopathy in Zucker diabetic fatty rats: the forgotten right ventricle. Cardiovasc Diabetol. 2010;9:25 pubmed publisher
    ..The purpose of the present study was to investigate whether LV changes are paralleled by RV alterations in a rat model of diabetes...
  2. Flamment M, Arvier M, Gallois Y, Simard G, Malthiery Y, Ritz P, et al. Fatty liver and insulin resistance in obese Zucker rats: no role for mitochondrial dysfunction. Biochimie. 2008;90:1407-13 pubmed publisher
    ..mitochondrial function in fatty liver and insulin resistance state using isolated mitochondria from obese Zucker rats. We determined the relationship between ATP synthesis and oxygen consumption as well as the relationship ..
  3. Peterson J, Bryner R, Alway S. Satellite cell proliferation is reduced in muscles of obese Zucker rats but restored with loading. Am J Physiol Cell Physiol. 2008;295:C521-8 pubmed publisher
  4. Koch T, Briviba K, Watzl B, Bub A, Barth S. Obesity-related promotion of aberrant crypt foci in DMH-treated obese Zucker rats correlates with dyslipidemia rather than hyperinsulinemia. Eur J Nutr. 2008;47:161-70 pubmed publisher
    ..Obesity and energy restriction modulate the development of precancerous aberrant crypt foci (ACF) in animal models of colon cancer...
  5. De Feyter H, Lenaers E, Houten S, Schrauwen P, Hesselink M, Wanders R, et al. Increased intramyocellular lipid content but normal skeletal muscle mitochondrial oxidative capacity throughout the pathogenesis of type 2 diabetes. FASEB J. 2008;22:3947-55 pubmed publisher
    ..Accordingly, we can conclude that in the ZDF rat model, type 2 diabetes develops in the absence of skeletal muscle mitochondrial dysfunction...
  6. Mingorance C, Gonzalez del Pozo M, Dolores Herrera M, Alvarez de Sotomayor M. Oral supplementation of propionyl-l-carnitine reduces body weight and hyperinsulinaemia in obese Zucker rats. Br J Nutr. 2009;102:1145-53 pubmed publisher
    ..on an animal model of obesity, insulin resistance and, consequently, endothelial dysfunction, lean and obese Zucker rats (OZR) received either vehicle- or PLC-supplemented drinking water (200 mg/kg per d) for 20 weeks...
  7. Goodwill A, James M, Frisbee J. Increased vascular thromboxane generation impairs dilation of skeletal muscle arterioles of obese Zucker rats with reduced oxygen tension. Am J Physiol Heart Circ Physiol. 2008;295:H1522-8 pubmed publisher
    ..with reduced Po(2) contributes to impaired hypoxic dilation of skeletal muscle resistance arterioles of obese Zucker rats (OZRs) versus lean Zucker rats (LZRs)...
  8. Madala Halagappa V, Tiwari S, Riazi S, Hu X, Ecelbarger C. Chronic candesartan alters expression and activity of NKCC2, NCC, and ENaC in the obese Zucker rat. Am J Physiol Renal Physiol. 2008;294:F1222-31 pubmed publisher
    ..lean Zucker rats. Male obese and lean Zucker rats (10-wk old) were fed either 1) control chow (1% NaCl) or 2) chow with ..
  9. Zhao X, Li L. PPAR-alpha agonist fenofibrate induces renal CYP enzymes and reduces blood pressure and glomerular hypertrophy in Zucker diabetic fatty rats. Am J Nephrol. 2008;28:598-606 pubmed publisher
  10. Rivera L, Morón R, Sanchez M, Zarzuelo A, Galisteo M. Quercetin ameliorates metabolic syndrome and improves the inflammatory status in obese Zucker rats. Obesity (Silver Spring). 2008;16:2081-7 pubmed publisher
    ..For this purpose, obese Zucker rats and their lean littermates were used...
  11. Ruth M, Taylor C, Zahradka P, Field C. Abnormal immune responses in fa/fa Zucker rats and effects of feeding conjugated linoleic acid. Obesity (Silver Spring). 2008;16:1770-9 pubmed publisher
    ..The objective of this study was to characterize immune function in the fa/fa Zucker rat, and to determine the effects of feeding conjugated linoleic acid (CLA) isomers on immune function...
  12. Lu M, Tzang B, Kuo W, Wu F, Chen Y, Tsai C, et al. More activated cardiac mitochondrial-dependent apoptotic pathway in obese Zucker rats. Obesity (Silver Spring). 2007;15:2634-42 pubmed
    ..The purpose of this study was to evaluate the key components of the mitochondrial-dependent apoptotic pathway in excised heart from obese Zucker rats.
  13. Siddiqui A, Ali Q, Hussain T. Protective role of angiotensin II subtype 2 receptor in blood pressure increase in obese Zucker rats. Hypertension. 2009;53:256-61 pubmed publisher
    ..AT(2) agonist inhibits Na,K-ATPase activity in the proximal tubules and increases urinary Na excretion in obese Zucker rats. We hypothesized that the AT(2) receptor has a protective role against blood pressure increase in obese Zucker ..
  14. Carpene C, Iffiú Soltész Z, Bour S, Prevot D, Valet P. Reduction of fat deposition by combined inhibition of monoamine oxidases and semicarbazide-sensitive amine oxidases in obese Zucker rats. Pharmacol Res. 2007;56:522-30 pubmed
    ..p. administered for 3-5 weeks to obese Zucker rats at doses ranging from 20 to 300 micromol/kg...
  15. Whaley Connell A, Demarco V, Lastra G, Manrique C, Nistala R, Cooper S, et al. Insulin resistance, oxidative stress, and podocyte injury: role of rosuvastatin modulation of filtration barrier injury. Am J Nephrol. 2008;28:67-75 pubmed
    ..The glomerular filtration barrier is emerging as a critical determinant of albumin filtration. We investigated the effects of insulin resistance and rosuvastatin or placebo on the glomerular filtration barrier...
  16. Morrison R, Mills C, Moran A, Walton C, Sadek M, Mangiarua E, et al. A moderately high fat diet promotes salt-sensitive hypertension in obese zucker rats by impairing nitric oxide production. Clin Exp Hypertens. 2007;29:369-81 pubmed
    ..the contribution of a moderately high fat (MHF) diet to the development of salt-sensitive hypertension in obese Zucker rats. Lean and obese Zucker rats were fed either a MHF diet or a diet of standard rat chow (control diet) for 10 ..
  17. Huber D, Schreihofer A. Attenuated baroreflex control of sympathetic nerve activity in obese Zucker rats by central mechanisms. J Physiol. 2010;588:1515-25 pubmed publisher
    Adult obese Zucker rats (OZRs) have reduced sympathetic responses to evoked changes in arterial pressure (AP) compared to lean Zucker rats (LZRs)...
  18. Tabatabai N, Sharma M, Blumenthal S, Petering D. Enhanced expressions of sodium-glucose cotransporters in the kidneys of diabetic Zucker rats. Diabetes Res Clin Pract. 2009;83:e27-30 pubmed publisher
    ..Diabetes-mediated changes in mRNA expressions of kidney glucose transporters SGLT1 and SGLT2 were investigated in Zucker rats. SGLTs expressions in pre-diabetic obese rats were similar to leans...
  19. Teixeira de Lemos E, Reis F, Baptista S, Pinto R, Sepodes B, Vala H, et al. Exercise training decreases proinflammatory profile in Zucker diabetic (type 2) fatty rats. Nutrition. 2009;25:330-9 pubmed publisher
  20. Forcheron F, Basset A, Abdallah P, Del Carmine P, Gadot N, Beylot M. Diabetic cardiomyopathy: effects of fenofibrate and metformin in an experimental model--the Zucker diabetic rat. Cardiovasc Diabetol. 2009;8:16 pubmed publisher
    ..We evaluated the possible usefulness of two molecules promoting lipid oxidation, fenofibrate and metformin, in an experimental model of DCM, the Zucker diabetic rat (ZDF)...
  21. Sato K, Arai H, Miyazawa Y, Fukaya M, Uebanso T, Koganei M, et al. Palatinose and oleic acid act together to prevent pancreatic islet disruption in nondiabetic obese Zucker rats. J Med Invest. 2008;55:183-95 pubmed
    ..These findings suggest that pancreatic islets may be initial sites that translate the effects of different combinations of dietary carbohydrates and fats into metabolic changes...
  22. Zarate J, Churruca I, Echevarria E, Casis L, López de Jesús M, Saenz del Burgo L, et al. Immunohistochemical localization of CB1 cannabinoid receptors in frontal cortex and related limbic areas in obese Zucker rats: effects of chronic fluoxetine treatment. Brain Res. 2008;1236:57-72 pubmed publisher
    ..CB1 cannabinoid receptor at the histochemical level in frontal cortex and related limbic areas of the obese Zucker rats. Higher levels of CB1 receptor expression in frontal, cingulated and piriform cortex, without differences in ..
  23. Song J, Liu H, Ressom H, Tiwari S, Ecelbarger C. Chronic rosiglitazone therapy normalizes expression of ACE1, SCD1 and other genes in the kidney of obese Zucker rats as determined by microarray analysis. Exp Clin Endocrinol Diabetes. 2008;116:315-25 pubmed
    ..We examined kidney gene expression in obese and lean Zucker rats in response to rosiglitazone (Avandia), a peroxisome proliferator activated receptor (gamma-subtype) agonist...
  24. Radovits T, Korkmaz S, Loganathan S, Barnucz E, Bömicke T, Arif R, et al. Comparative investigation of the left ventricular pressure-volume relationship in rat models of type 1 and type 2 diabetes mellitus. Am J Physiol Heart Circ Physiol. 2009;297:H125-33 pubmed publisher
    ..Based on the sophisticated method of P-V analysis, different characteristics of type 1 and type 2 diabetic cardiac dysfunction can be demonstrated...
  25. Forcheron F, Abdallah P, Basset A, Del Carmine P, Haffar G, Beylot M. Nonalcoholic hepatic steatosis in Zucker diabetic rats: spontaneous evolution and effects of metformin and fenofibrate. Obesity (Silver Spring). 2009;17:1381-9 pubmed publisher
    ..To conclude, metformin had only moderate effects on liver steatosis. The effects of fenofibrate was more marked but remained mild...
  26. Shoghi K, Gropler R, Sharp T, Herrero P, Fettig N, Su Y, et al. Time course of alterations in myocardial glucose utilization in the Zucker diabetic fatty rat with correlation to gene expression of glucose transporters: a small-animal PET investigation. J Nucl Med. 2008;49:1320-7 pubmed publisher
  27. Kajihara T, Uchino S, Suzuki M, Itakura A, Brosens J, Ishihara O. Increased ovarian follicle atresia in obese Zucker rats is associated with enhanced expression of the forkhead transcription factor FOXO1. Med Mol Morphol. 2009;42:216-21 pubmed publisher
    ..was to investigate if ovarian follicular development and atresia are impaired in obese hyperinsulinemic (fa/fa) Zucker rats. To gain insight into the molecular mechanism of follicular atresia, we also examined the expression and ..
  28. Liu I, Tzeng T, Liou S, Lan T. Improvement of insulin sensitivity in obese Zucker rats by myricetin extracted from Abelmoschus moschatus. Planta Med. 2007;73:1054-60 pubmed
    In an attempt to develop new substances for treating insulin resistance, obese Zucker rats were employed to screen the effect of myricetin, an active principle of Abelmoschus moschatus (Malvaceae), on insulin resistance...
  29. Oltman C, Davidson E, Coppey L, Kleinschmidt T, Lund D, Adebara E, et al. Vascular and neural dysfunction in Zucker diabetic fatty rats: a difficult condition to reverse. Diabetes Obes Metab. 2008;10:64-74 pubmed
    ..We had previously demonstrated that vascular and neural dysfunction in Zucker diabetic fatty (ZDF) rats is progressive. In this study, we sought to determine whether monotherapy of ZDF rats can reverse the vascular and nerve defects...
  30. Song D, Kuo K, Yao R, Hutchings S, Pang C. Inducible nitric oxide synthase depresses cardiac contractile function in Zucker diabetic fatty rats. Eur J Pharmacol. 2008;579:253-9 pubmed
    ..The results indicate that activation of iNOS contributed to left ventricular contractile dysfunction in the ZDF rats, and this was partially reversed by selective inhibition of the activity of iNOS...
  31. Riazi S, Madala Halagappa V, Dantas A, Hu X, Ecelbarger C. Sex differences in renal nitric oxide synthase, NAD(P)H oxidase, and blood pressure in obese Zucker rats. Gend Med. 2007;4:214-29 pubmed
    ..By increasing renal oxidative stress, obesity may alter the protective effect of female sex on blood pressure (BP)...
  32. Schafer A, Pfrang J, Neumüller J, Fiedler S, Ertl G, Bauersachs J. The cannabinoid receptor-1 antagonist rimonabant inhibits platelet activation and reduces pro-inflammatory chemokines and leukocytes in Zucker rats. Br J Pharmacol. 2008;154:1047-54 pubmed publisher
    We investigated the effect of rimonabant on inflammation and enhanced platelet reactivity in type 2 diabetic Zucker rats, an experimental model of impaired glucose tolerance and the metabolic syndrome.
  33. Hamad E, Sato M, Uzu K, Yoshida T, Higashi S, Kawakami H, et al. Milk fermented by Lactobacillus gasseri SBT2055 influences adipocyte size via inhibition of dietary fat absorption in Zucker rats. Br J Nutr. 2009;101:716-24 pubmed publisher
    ..In experiment 1, lean and obese Zucker rats were fed a diet containing SM or LGSP for 4 weeks...
  34. Pavón F, Serrano A, Perez Valero V, Jagerovic N, Hernandez Folgado L, Bermudez Silva F, et al. Central versus peripheral antagonism of cannabinoid CB1 receptor in obesity: effects of LH-21, a peripherally acting neutral cannabinoid receptor antagonist, in Zucker rats. J Neuroendocrinol. 2008;20 Suppl 1:116-23 pubmed publisher
    ..but does not improve hypertriglyceridaemia or hypercholesterolaemia; nor does it reduce liver fat deposits in Zucker rats. These results suggest that the inverse agonism and/or the antagonism of central cannabinoid CB(1) receptors ..
  35. Sanchez A, Contreras C, Villalba N, Martinez P, Martinez A, Briones A, et al. Altered arachidonic acid metabolism via COX-1 and COX-2 contributes to the endothelial dysfunction of penile arteries from obese Zucker rats. Br J Pharmacol. 2010;159:604-16 pubmed publisher
    The aim of the current study was to investigate the role of arachidonic acid (AA) metabolism via cyclooxygenase (COX) in the endothelial dysfunction of penile arteries from pre-diabetic, obese Zucker rats (OZR).
  36. Liao J, Soltani Z, Ebenezer P, Isidro Carrión A, Zhang R, Asghar A, et al. Tesaglitazar, a dual peroxisome proliferator-activated receptor agonist (PPAR alpha/gamma), improves metabolic abnormalities and reduces renal injury in obese Zucker rats. Nephron Exp Nephrol. 2010;114:e61-8 pubmed publisher
    ..receptor (PPAR)alpha/gamma agonist, on metabolic abnormalities and kidney injury in obese Zucker rats (OZR). Lean Zucker rats (LZR) and OZR were used as control groups...
  37. Xiang L, Dearman J, Abram S, Carter C, Hester R. Insulin resistance and impaired functional vasodilation in obese Zucker rats. Am J Physiol Heart Circ Physiol. 2008;294:H1658-66 pubmed publisher
    ..We have shown that impaired functional vasodilation in obese Zucker rats (OZRs) is associated with enhanced thromboxane receptor (TP)-mediated vasoconstriction...
  38. Batetta B, Griinari M, Carta G, Murru E, Ligresti A, Cordeddu L, et al. Endocannabinoids may mediate the ability of (n-3) fatty acids to reduce ectopic fat and inflammatory mediators in obese Zucker rats. J Nutr. 2009;139:1495-501 pubmed publisher
    ..and DHA and similar contents of oleic, linoleic, and alpha-linolenic acids, on ectopic fat and inflammation in Zucker rats, a model of obesity and related metabolic dysfunction. Diets were fed for 4 wk...
  39. Alemzadeh R, Karlstad M, Tushaus K, Buchholz M. Diazoxide enhances basal metabolic rate and fat oxidation in obese Zucker rats. Metabolism. 2008;57:1597-607 pubmed publisher
    Persistent suppression of hyperinsulinemia in genetically obese (fa/fa) Zucker rats by diazoxide (DZ) reduces food intake and weight gain; improves insulin sensitivity, glycemic control, and lipid profile; and enhances beta(3)-adrenergic ..
  40. Hodnett B, Dearman J, Carter C, Hester R. Attenuated PGI2 synthesis in obese Zucker rats. Am J Physiol Regul Integr Comp Physiol. 2009;296:R715-21 pubmed publisher
    ..Following AA administration, PGI(2) and PGE(2) release were attenuated in OZR compared with lean Zucker rats (LZR; controls). Basal and AA-induced TXA(2) release were not significantly different between groups...
  41. Zdychova J, Kazdova L, Pelikanova T, Lindsley J, Anderson S, Komers R. Renal activity of Akt kinase in obese Zucker rats. Exp Biol Med (Maywood). 2008;233:1231-41 pubmed publisher
    ..To address this issue, renal cortical Akt was determined in obese Zucker rats (ZO), a model of DM2, and lean controls (ZL)...
  42. Schreihofer A, Mandel D, Mobley S, Stepp D. Impairment of sympathetic baroreceptor reflexes in obese Zucker rats. Am J Physiol Heart Circ Physiol. 2007;293:H2543-9 pubmed
    Adult obese Zucker rats (OZRs) have elevated sympathetic vasomotor tone and arterial pressure (AP) with blunted baroreflex-mediated changes in heart rate (HR) compared with adult lean Zucker rats (LZRs)...
  43. Ebenezer P, Mariappan N, Elks C, Haque M, Francis J. Diet-induced renal changes in Zucker rats are ameliorated by the superoxide dismutase mimetic TEMPOL. Obesity (Silver Spring). 2009;17:1994-2002 pubmed publisher
    ..Heterozygous lean Zucker rats (LZRs; fa/+) are susceptible to high-fat diet (HFD)-induced obesity and MetS...
  44. Baynes J, Murray D. The metal chelators, trientine and citrate, inhibit the development of cardiac pathology in the Zucker diabetic rat. Exp Diabetes Res. 2009;2009:696378 pubmed publisher
    ..The objective of this study was to determine the efficacy of dietary supplementation with the metal chelators, trientine or citric acid, in preventing the development of cardiomyopathy in the Zucker diabetic rat...
  45. Toblli J, Muñoz M, Cao G, Mella J, Pereyra L, Mastai R. ACE inhibition and AT1 receptor blockade prevent fatty liver and fibrosis in obese Zucker rats. Obesity (Silver Spring). 2008;16:770-6 pubmed publisher
  46. Behl Y, Krothapalli P, Desta T, DiPiazza A, Roy S, Graves D. Diabetes-enhanced tumor necrosis factor-alpha production promotes apoptosis and the loss of retinal microvascular cells in type 1 and type 2 models of diabetic retinopathy. Am J Pathol. 2008;172:1411-8 pubmed publisher
  47. Davis L, Michaelides M, Cheskin L, Moran T, Aja S, Watkins P, et al. Bromocriptine administration reduces hyperphagia and adiposity and differentially affects dopamine D2 receptor and transporter binding in leptin-receptor-deficient Zucker rats and rats with diet-induced obesity. Neuroendocrinology. 2009;89:152-62 pubmed publisher
  48. Huhn R, Heinen A, Weber N, Kerindongo R, Oei G, Hollmann M, et al. Helium-induced early preconditioning and postconditioning are abolished in obese Zucker rats in vivo. J Pharmacol Exp Ther. 2009;329:600-7 pubmed publisher
    ..Here, we investigated: 1) whether helium induces pre- and postconditioning in Zucker rats and 2) whether possible regulators of the mPTP [i.e...
  49. Barat P, Livingstone D, Elferink C, McDonnell C, Walker B, Andrew R. Effects of gonadectomy on glucocorticoid metabolism in obese Zucker rats. Endocrinology. 2007;148:4836-43 pubmed
    ..Steroid metabolism was studied in obese and lean male Zucker rats (age 10 wk, 10 animals per group) 4 wk after gonadectomy or sham surgery...
  50. Oltman C, Davidson E, Coppey L, Kleinschmidt T, Lund D, Yorek M. Attenuation of vascular/neural dysfunction in Zucker rats treated with enalapril or rosuvastatin. Obesity (Silver Spring). 2008;16:82-9 pubmed publisher
    Obese Zucker rats, animal model for the metabolic syndrome, develop a diabetes-like neuropathy that is independent of hyperglycemia...
  51. Holloway G, Benton C, Mullen K, Yoshida Y, Snook L, Han X, et al. In obese rat muscle transport of palmitate is increased and is channeled to triacylglycerol storage despite an increase in mitochondrial palmitate oxidation. Am J Physiol Endocrinol Metab. 2009;296:E738-47 pubmed publisher
    ..Therefore, in red and white muscles of lean and obese Zucker rats, we examined whether the increase in IMTG accumulation was attributable to an increased rate of fatty acid ..
  52. Bairras C, Mauriege P, Bukowiecki L, Atgie C. Regulation of lypolysis in white adipose tissues of lean and obese Zucker rats. J Physiol Biochem. 2007;63:287-96 pubmed
    ..the Zucker rat, the lipolytic activities of adipocytes isolated from different adipose depots of lean and obese Zucker rats, in the basal state or after catecholamine stimulation have been measured...
  53. Tiwari S, Halagappa V, Riazi S, Hu X, Ecelbarger C. Reduced expression of insulin receptors in the kidneys of insulin-resistant rats. J Am Soc Nephrol. 2007;18:2661-71 pubmed
    ..Treatment of insulin resistance in Zucker rats with the insulin-sensitizing drug rosiglitazone partially restored renal insulin receptor levels...
  54. Ferrigno A, Carlucci F, Tabucchi A, Tommassini V, Rizzo V, Richelmi P, et al. Different susceptibility of liver grafts from lean and obese Zucker rats to preservation injury. Cryobiology. 2009;59:327-34 pubmed publisher
    We compared the susceptibility of liver grafts from lean and obese Zucker rats to preservation injury, using two organ-preservation techniques: conventional static preservation (SP) and machine perfusion (MP) preservation...
  55. Galisteo M, Morón R, Rivera L, Romero R, Anguera A, Zarzuelo A. Plantago ovata husks-supplemented diet ameliorates metabolic alterations in obese Zucker rats through activation of AMP-activated protein kinase. Comparative study with other dietary fibers. Clin Nutr. 2010;29:261-7 pubmed publisher
  56. Boor P, Celec P, Behuliak M, Grancic P, Kebis A, Kukan M, et al. Regular moderate exercise reduces advanced glycation and ameliorates early diabetic nephropathy in obese Zucker rats. Metabolism. 2009;58:1669-77 pubmed publisher
    ..Here we examined whether a regular moderate exercise in obese Zucker rats (OZR), a model of diabetes- and obesity-associated nephropathy, will affect the development of early renal ..
  57. Villalba N, Martinez P, Bríones A, Sanchez A, Salaices M, García Sacristán A, et al. Differential structural and functional changes in penile and coronary arteries from obese Zucker rats. Am J Physiol Heart Circ Physiol. 2009;297:H696-707 pubmed publisher
    ..PAs and CAs from 17- to 18-wk-old obese Zucker rats (OZRs) and from their control counterparts [lean Zucker rats (LZRs)] were mounted in microvascular myographs to ..
  58. Agouni A, Lagrue Lak Hal A, Mostefai H, Tesse A, Mulder P, Rouet P, et al. Red wine polyphenols prevent metabolic and cardiovascular alterations associated with obesity in Zucker fatty rats (Fa/Fa). PLoS ONE. 2009;4:e5557 pubmed publisher
  59. Monteiro M, Ribeiro A, Nunes A, Sousa M, Monteiro J, Aguas A, et al. Increase in ghrelin levels after weight loss in obese Zucker rats is prevented by gastric banding. Obes Surg. 2007;17:1599-607 pubmed
    ..Our aim was to investigate the changes in orexigenic signals in the obese Zucker rat after gastric banding...
  60. Lee S, Tzang B, Kuo W, Lin Y, Yang A, Chen S, et al. Cardiac fas receptor-dependent apoptotic pathway in obese Zucker rats. Obesity (Silver Spring). 2007;15:2407-15 pubmed
    Very limited information regarding the cardiac molecular mechanism in obesity is available. The purpose of this study was to evaluate the cardiac Fas receptor-dependent (type I) apoptotic pathway in obese Zucker rats.
  61. Kim D, Burgess A, Li M, Tsenovoy P, Addabbo F, McClung J, et al. Heme oxygenase-mediated increases in adiponectin decrease fat content and inflammatory cytokines tumor necrosis factor-alpha and interleukin-6 in Zucker rats and reduce adipogenesis in human mesenchymal stem cells. J Pharmacol Exp Ther. 2008;325:833-40 pubmed publisher
    ..These findings highlight the pivotal role and symbiotic relationship of HO-1 and adiponectin in the modulation of the metabolic syndrome phenotype...
  62. Hsieh Y, Chang C, Hsu K, Tsai F, Chen C, Tsai H. Effect of exercise training on calpain systems in lean and obese Zucker rats. Int J Biol Sci. 2008;4:300-8 pubmed
    ..investigate the influence of exercise upon the calcium-dependent calpain-isoform expressions of lean or obese Zucker rats, a model of obesity and type II diabetes (NIDDM)...