brattleboro rats


Summary: A mutant strain of Rattus norvegicus used in research on renal function and hypertension and as a disease model for diabetes insipidus.

Top Publications

  1. Zelena D, Domokos A, Barna I, Mergl Z, Haller J, Makara G. Control of the hypothalamo-pituitary-adrenal axis in the neonatal period: adrenocorticotropin and corticosterone stress responses dissociate in vasopressin-deficient brattleboro rats. Endocrinology. 2008;149:2576-83 pubmed publisher
    ..We investigated the role of AVP by studying stress responses in 5, 10, and 20-d-old AVP-deficient Brattleboro rats. Two different stressors were applied: 24-h maternal separation and Hypnorm Grove Oxford UK injections...
  2. Schmale H, Richter D. Single base deletion in the vasopressin gene is the cause of diabetes insipidus in Brattleboro rats. Nature. 1984;308:705-9 pubmed
    In rats with hereditary hypothalamic diabetes insipidus (Brattleboro rats) the gene for the vasopressin precursor lacks a single G residue in the protein-coding region...
  3. Promeneur D, Kwon T, Frøkiaer J, Knepper M, Nielsen S. Vasopressin V(2)-receptor-dependent regulation of AQP2 expression in Brattleboro rats. Am J Physiol Renal Physiol. 2000;279:F370-82 pubmed
  4. Zelena D, Mergl Z, Makara G. Maternal genotype influences stress reactivity of vasopressin-deficient brattleboro rats. J Neuroendocrinol. 2003;15:1105-10 pubmed
    ..normal as well as reduced adrenocorticotropin hormone (ACTH) rise to an acute challenge has been reported in Brattleboro rats genetically lacking vasopressin (di/di)...
  5. Feifel D, Melendez G, Priebe K, Shilling P. The effects of chronic administration of established and putative antipsychotics on natural prepulse inhibition deficits in Brattleboro rats. Behav Brain Res. 2007;181:278-86 pubmed
    ..e., peptides) and reasonably model the therapeutic time course of antipsychotic drugs in humans...
  6. Zelena D, Mergl Z, Makara G. Postnatal development in vasopressin deficient Brattleboro rats with special attention to the hypothalamo-pituitary-adrenal axis function: the role of maternal genotype. Int J Dev Neurosci. 2009;27:175-83 pubmed publisher
    ..We compared homozygous vasopressin deficient (di/di) Brattleboro rats to their heterozygous (di/+) littermates both from di/+ and di/di mother...
  7. Zelena D, Földes A, Mergl Z, Barna I, Kovacs K, Makara G. Effects of repeated restraint stress on hypothalamo-pituitary-adrenocortical function in vasopressin deficient Brattleboro rats. Brain Res Bull. 2004;63:521-30 pubmed
    ..Heterozygous Brattleboro rats (di/+) served as controls and were compared to homozygous rats (di/di) with diabetes insipidus...
  8. Zelena D, Langnaese K, Domokos A, Pintér O, Landgraf R, Makara G, et al. Vasopressin administration into the paraventricular nucleus normalizes plasma oxytocin and corticosterone levels in Brattleboro rats. Endocrinology. 2009;150:2791-8 pubmed publisher
    ..Thus, endogenous vasopressin released within the PVN is likely to act as a paracrine signal to facilitate the return of plasma oxytocin and corticosterone to basal levels after acute stressor exposure...
  9. Ideno J, Mizukami H, Honda K, Okada T, Hanazono Y, Kume A, et al. Persistent phenotypic correction of central diabetes insipidus using adeno-associated virus vector expressing arginine-vasopressin in Brattleboro rats. Mol Ther. 2003;8:895-902 pubmed
    ..we injected AAV vector encoding arginine-vasopressin (AVP) stereotaxically into the bilateral hypothalamus of Brattleboro rats. Brattleboro rats show a central diabetes insipidus (CDI) phenotype and growth retardation due to a complete ..

More Information


  1. Jentsch J, Arguello P, Anzivino L. Null mutation of the arginine-vasopressin gene in rats slows attentional engagement and facilitates response accuracy in a lateralized reaction time task. Neuropsychopharmacology. 2003;28:1597-605 pubmed
    ..Here, the results of studies of homozygous Brattleboro rats that are fully vasopressin deficient are reported...
  2. Feifel D, Priebe K. Vasopressin-deficient rats exhibit sensorimotor gating deficits that are reversed by subchronic haloperidol. Biol Psychiatry. 2001;50:425-33 pubmed
    ..b>Brattleboro rats are known to have deficits in memory, emotional reactivity, motivation, attention, and social recognition, ..
  3. Bundzikova J, Pirnik Z, Zelena D, Mikkelsen J, Kiss A. Response of substances co-expressed in hypothalamic magnocellular neurons to osmotic challenges in normal and Brattleboro rats. Cell Mol Neurobiol. 2008;28:1033-47 pubmed publisher
  4. Feifel D, Melendez G, Shilling P. Reversal of sensorimotor gating deficits in Brattleboro rats by acute administration of clozapine and a neurotensin agonist, but not haloperidol: a potential predictive model for novel antipsychotic effects. Neuropsychopharmacology. 2004;29:731-8 pubmed
  5. Domokos A, Mergl Z, Barna I, Makara G, Zelena D. Congenital vasopressin deficiency and acute and chronic opiate effects on hypothalamo-pituitary-adrenal axis activity in Brattleboro rats. J Endocrinol. 2008;196:113-21 pubmed publisher
    ..Our data suggest that vasopressin plays a prominent role in morphine treatment and withdrawal-induced acute hormonal changes, but does not affect development of chronic hyperactivity of the HPA axis...
  6. Kim D, Sands J, Klein J. Role of vasopressin in diabetes mellitus-induced changes in medullary transport proteins involved in urine concentration in Brattleboro rats. Am J Physiol Renal Physiol. 2004;286:F760-6 pubmed necessary for these diabetes mellitus-induced changes in UT-A1, AQP2, or NKCC2/BSC1, we studied Brattleboro rats because they lack vasopressin. Brattleboro rats were given vasopressin (2...
  7. Zelena D, Mergl Z, Makara G. The role of vasopressin in diabetes mellitus-induced hypothalamo-pituitary-adrenal axis activation: studies in Brattleboro rats. Brain Res Bull. 2006;69:48-56 pubmed
    ..AVP-deficient mutant Brattleboro rats were used with heterozygous controls and the V2 agonist, desmopressin was infused to replace peripheral AVP...
  8. Li C, Wang W, Summer S, Cadnapaphornchai M, Falk S, Umenishi F, et al. Hyperosmolality in vivo upregulates aquaporin 2 water channel and Na-K-2Cl co-transporter in Brattleboro rats. J Am Soc Nephrol. 2006;17:1657-64 pubmed
    ..05), and cortex plus outer stripe of outer medulla NKCC2 (142+/-16 versus 100+/-9%; P<0.05). In conclusion, hyperosmolality, secondary to either glucose or NaCl, upregulated renal AQP2 and NKCC2 in vivo in BB rats...
  9. Shilling P, Kinkead B, Murray T, Melendez G, Nemeroff C, Feifel D. Upregulation of striatal dopamine-2 receptors in Brattleboro rats with prepulse inhibition deficits. Biol Psychiatry. 2006;60:1278-81 pubmed
    b>Brattleboro rats (BRATs) have natural deficits in prepulse inhibition (PPI) of the startle response similar to those exhibited by schizophrenia patients, which are reversed by antipsychotics...
  10. Mlynarik M, Zelena D, Bagdy G, Makara G, Jezova D. Signs of attenuated depression-like behavior in vasopressin deficient Brattleboro rats. Horm Behav. 2007;51:395-405 pubmed
    ..In the present study, we have tested the hypothesis that congenital deficit of vasopressin in Brattleboro rats leads to attenuated depression-like behavior in tests modeling different symptoms of depression...
  11. Feifel D, Priebe K. The effects of cross-fostering on inherent sensorimotor gating deficits exhibited by Brattleboro rats. J Gen Psychol. 2007;134:173-82 pubmed
    ..Cross-fostering of Long Evans and Brattleboro pups did not alter the PPI deficits in Brattleboro rats. However, the magnitude and habituation of the startle response, which normally differs between Brattleboro ..
  12. Hansell P, Göransson V, Odlind C, Gerdin B, Hallgren R. Hyaluronan content in the kidney in different states of body hydration. Kidney Int. 2000;58:2061-8 pubmed
    ..different states of renal water handling (euvolemia, water diuresis, antidiuresis), in desert rodents, and in Brattleboro rats (diabetes insipidus) with a hereditary difference in water handling, regional renal HA and water contents ..
  13. Ivanova L, Kochkaeva L, Melidi N. Effect of an increase in brain serotonin on the osmoregulatory response to a hypo- or hyperosmotic load in Wistar and vasopressin-deficient Brattleboro rats. Neuroendocrinology. 2007;85:242-8 pubmed
    ..on the response to an intragastric hypo- or hyperosmotic loading was studied in Wistar and AVP-deficient Brattleboro rats. 5-Hydroxytryptophan (5-HTP), the rate-limiting serotonin biosynthesis precursor known to increase the brain ..
  14. Foulkes R, Gardiner S, Bennett T. Exogenous corticosterone acetate attenuates the hypotension induced by ganglion blockade in conscious Long Evans and Brattleboro rats. J Pharmacol Exp Ther. 1987;243:1048-54 pubmed
    ..induced by pentolinium, captopril and d(CH2)5DAVP in Long Evans rats or by pentolinium and captopril in Brattleboro rats) caused a progressive increase in BP in both strains...
  15. Plotnikov M, Vasil ev A, Aliev O, Zibareva L. Brattleboro Rats as the Model of Blood Hyperviscosity Syndrome for Testing Substances with Hemorheological Activity. Bull Exp Biol Med. 2015;159:689-91 pubmed publisher
    Hyperviscosity syndrome was described in Brattleboro rats. The aim of this study was to investigate the possibility of Brattleboro rats using, as a test system for the study of agents with hemorheological activity...
  16. Cai Q, Dmitrieva N, Ferraris J, Brooks H, van Balkom B, Burg M. Pax2 expression occurs in renal medullary epithelial cells in vivo and in cell culture, is osmoregulated, and promotes osmotic tolerance. Proc Natl Acad Sci U S A. 2005;102:503-8 pubmed
    ..Treating Brattleboro rats with desamino-Cys-1,d-Arg-8 vasopressin, which increases inner-medullary NaCl concentration, causes a 4-fold ..
  17. Bundzikova J, Pirnik Z, Zelena D, Mikkelsen J, Kiss A. Alpha2-adrenergic impact on hypothalamic magnocellular oxytocinergic neurons in long evans and brattleboro rats: effects of agonist and antagonists. Cell Mol Neurobiol. 2009;29:1015-23 pubmed publisher
    ..These findings suggest that alpha2-adrenoceptors have only a limited impact in maintaining OXY cells activity upregulation in PVN and SON of di/di rats. ..
  18. Martin P, Bianchi M, Roger F, Niksic L, Feraille E. Arginine vasopressin modulates expression of neuronal NOS in rat renal medulla. Am J Physiol Renal Physiol. 2002;283:F559-68 pubmed
    ..Finally, the very low nNOS expression levels observed in AVP-deficient Brattleboro rats was restored by AVP infusion for 1 wk...
  19. Rao R, Zhang M, Zhao M, Cai H, Harris R, Breyer M, et al. Lithium treatment inhibits renal GSK-3 activity and promotes cyclooxygenase 2-dependent polyuria. Am J Physiol Renal Physiol. 2005;288:F642-9 pubmed
    ..In conclusion, these findings temporally link decreased GSK-3 activity to enhanced renal COX2 expression and COX2-derived urine PGE(2) excretion. Suppression of COX2-derived PGE(2) blunts lithium-associated polyuria...
  20. Murphy H, Wideman C, Nadzam G. The role of vasopressin in modulating circadian rhythm responses to phase shifts. Peptides. 1998;19:1191-208 pubmed
    ..The demonstrated role of vasopressin in synchronizing circadian rhythms to the LEO may be of significance in understanding human circadian rhythm disturbances, such as jet lag. ..
  21. Callewaere C, Fernette B, Raison D, Mechighel P, Burlet A, Calas A, et al. Cellular and subcellular evidence for neuronal interaction between the chemokine stromal cell-derived factor-1/CXCL 12 and vasopressin: regulation in the hypothalamo-neurohypophysial system of the Brattleboro rats. Endocrinology. 2008;149:310-9 pubmed
    ..Because the Brattleboro rats represent a good model of AVP deficiency, we tested in these animals the fate of SDF-1 and its receptor CXCR4...
  22. Boer G, van Esseveldt K, Dijkhuizen P, Hermens W, te Beek E, Van Heerikhuize J, et al. Adenoviral vector-mediated expression of neurotrophin-3 increases neuronal survival in suprachiasmatic nucleus grafts. Exp Neurol. 2001;169:364-75 pubmed
    ..However, in this group VIP staining volume area, not VP staining volume area, correlated significantly with reinstatement of circadian rhythm. ..
  23. Gunaratne R, Braucht D, Rinschen M, Chou C, Hoffert J, Pisitkun T, et al. Quantitative phosphoproteomic analysis reveals cAMP/vasopressin-dependent signaling pathways in native renal thick ascending limb cells. Proc Natl Acad Sci U S A. 2010;107:15653-8 pubmed publisher
    ..These results support the view that, although protein kinase A plays a central role in mTAL signaling, additional kinases, including those that target proline-directed motifs, may be involved. ..
  24. Pedersen N, Hofmeister M, Rosenbaek L, Nielsen J, Fenton R. Vasopressin induces phosphorylation of the thiazide-sensitive sodium chloride cotransporter in the distal convoluted tubule. Kidney Int. 2010;78:160-9 pubmed publisher
    ..In AVP-deficient Brattleboro rats, acute deamino-Cys-1, d-Arg-8 vasopressin (dDAVP) exposure significantly increased pNCC abundance at the ..
  25. Bouley R, Pastor Soler N, Cohen O, McLaughlin M, Breton S, Brown D. Stimulation of AQP2 membrane insertion in renal epithelial cells in vitro and in vivo by the cGMP phosphodiesterase inhibitor sildenafil citrate (Viagra). Am J Physiol Renal Physiol. 2005;288:F1103-12 pubmed
  26. Khegai I, Gulyaeva M, Popova N, Zakharova L, Ivanova L. Immune system in vasopressin-deficient rats during ontogeny. Bull Exp Biol Med. 2003;136:448-50 pubmed
    Morphofunctional immune disorders were revealed in vasopressin-deficient Brattleboro rats with diabetes insipidus during ontogeny...
  27. Barna I, Csabai K, Makara G, Zelena D. Cannabinoid-mediated regulation of the hypothalamo-pituitary-adrenal axis in rats: age dependent role of vasopressin. Endocr Regul. 2009;43:13-21 pubmed
    ..10-day-old and adult AVP deficient Brattleboro rats were compared with their heterozygous littermates 1h after WIN 55,212-2 (6mg/kg i.p.) injection...
  28. Widdop R, Gardiner S, Kemp P, Bennett T. Comparison of the regional haemodynamic effects of the AT1-receptor antagonists, losartan and EXP 3174, in water-deprived Brattleboro rats. Br J Pharmacol. 1993;108:684-8 pubmed
    1. Two separate groups (n = 8) of Brattleboro rats, chronically instrumented for the measurement of regional haemodynamics, underwent a 2-stage experimental protocol...
  29. Hayashi M, Arima H, Oiso Y. [Transgenic, knock-out and knock-in animal models for vasopressin neuron systems]. Nihon Rinsho. 2005;63 Suppl 3:466-70 pubmed
  30. Ivanova L, Lavrinenko V, Shestopalova L, Korotkova S. Structural and functional changes in epitheliocytes of collecting tubes in renal papilla of Brattleboro rats treated with vasopressin. Bull Exp Biol Med. 2007;143:94-8 pubmed desmopressin and morphological changes in epitheliocytes of collecting tubes were studied on homozygotic Brattleboro rats. Redistribution of beta-glucuronidase fractions and increase in the number of osmiophilic granules reflecting ..
  31. Shvarts E, Guliaeva L, Liakhovich V. [Interstrain differences in enzymatic activity of CYP2B1 and expression of its gene in the rat liver during induction with phenobarbital and triphenyldioxane]. Vopr Med Khim. 1999;45:30-6 pubmed
    ..Thus, differences in transcriptional activity of CYP2B1 gene during induction by phenobarbital and triphenyldioxane may be one of reasons for interstrain differences between enzymatic activities of rat liver cytochrome P4502B1. ..
  32. Chen M, Todd Turla K, Wang W, Cao X, Smart A, Brosius F, et al. Endothelin-1 mRNA in glomerular and epithelial cells of kidney. Am J Physiol. 1993;265:F542-50 pubmed
    ..In kidneys of untreated, homozygous Brattleboro rats, the increase of ET-1 mRNA along the corticomedullary axis as well as the preponderance of tubular ET-1 mRNA ..
  33. Jentsch J. Genetic vasopressin deficiency facilitates performance of a lateralized reaction-time task: altered attention and motor processes. J Neurosci. 2003;23:1066-71 pubmed
    b>Brattleboro rats are a variety of the outbred Long-Evans strain that possess a single nucleotide deletion in the second exon of the arginine vasopressin gene, resulting in the synthesis of an altered protein that does not enter the normal ..
  34. Lavrinenko V, Babina A. Efficiency of Osmotic Concentration after Combined Treatment with Vasopressin and Blockage of Prostaglandin Synthesis. Bull Exp Biol Med. 2016;162:187-190 pubmed
    ..desmopressin in the kidneys of Wistar rats with normal synthesis of endogenous vasopressin and homozygous Brattleboro rats with hereditary impaired synthesis of neurohypophyseal hormone vasopressin...
  35. Delbarre B, Delbarre G, Ferger A. [Role of prostaglandins in the mechanism of action of indapamide]. Arch Mal Coeur Vaiss. 1990;83:1209-12 pubmed
    ..In order to eliminate the importance of VP, we used Brattleboro rats (genetically depleted in VP): indapamide (3 mg/kg i.p.) maintains its hypotensive activity...
  36. Blankenstein K, Borschewski A, Labes R, Paliege A, Boldt C, McCormick J, et al. Calcineurin inhibitor cyclosporine A activates renal Na-K-Cl cotransporters via local and systemic mechanisms. Am J Physiol Renal Physiol. 2017;312:F489-F501 pubmed publisher
    ..To resolve this issue, the effects of CsA treatment in normal Wistar rats, AVP-deficient Brattleboro rats, and cultured renal epithelial cells endogenously expressing either NKCC2 or NCC were studied...
  37. Grant F. Genetic models of vasopressin deficiency. Exp Physiol. 2000;85 Spec No:203S-209S pubmed
    ..As advanced techniques of genetic manipulation become more reliable, conditional expression of vasopressin, regulated by time or body site will permit even more detailed studies in this field. ..
  38. Feifel D, Shilling P, Fazlinejad A, Melendez G. Antipsychotic drug-like facilitation of latent inhibition by a brain-penetrating neurotensin-1 receptor agonist. J Psychopharmacol. 2016;30:312-7 pubmed publisher
    ..the ability of a brain-penetrating, selective NTS1 agonist, PD149163, to facilitate LI in heterozygous Brattleboro rats, a strain that exhibits naturally low LI. Conditioned taste aversion to flavored water (FW; 0...
  39. Morcos M, Sayed A, Bierhaus A, Yard B, Waldherr R, Merz W, et al. Activation of tubular epithelial cells in diabetic nephropathy. Diabetes. 2002;51:3532-44 pubmed
  40. Mezey E. Vasoactive intestinal polypeptide immunopositive neurons in the paraventricular nucleus of homozygous Brattleboro rats. Neuroendocrinology. 1986;42:88-90 pubmed
    ..These immunoreactive perikarya in the PVN cannot be detected in colchicine-treated Long-Evans animals. When Brattleboro rats are administered vasopressin, there is a significant decrease in the number of VIP-immunopositive cell bodies ..
  41. Amlal H, Sheriff S, Faroqui S, Ma L, Barone S, Petrovic S, et al. Regulation of acid-base transporters by vasopressin in the kidney collecting duct of Brattleboro rat. Am J Nephrol. 2006;26:194-205 pubmed
    ..b>Brattleboro rats were placed in metabolic cages and treated with daily injections of 1-desamino-8-D-arginine vasopressin (..
  42. Ivanova L, Kabilova N, Bondar A. [Effect of dDAVP, agonist of V2 vasopressin receptor on the hyaluronidase-1 and hyaluronidase-2 gene expression in the kidneys of Wistar and Brattleboro rats]. Ross Fiziol Zh Im I M Sechenova. 2007;93:494-504 pubmed
    ..Desmopressin (dDAVP) exerts a stimulating effect on Hyal-1 and Hyal-2 gene expression in the medulla...
  43. Yokoyama O, Matsuta Y, Yanai Inamura H, Watanabe M, Ohtake A, Suzuki M, et al. Zolpidem increases bladder capacity and decreases urine excretion in rats. Neurourol Urodyn. 2010;29:587-91 pubmed publisher
  44. Zelena D, Domokos A, Jain S, Jankord R, Filaretova L. The stimuli-specific role of vasopressin in the hypothalamus-pituitary-adrenal axis response to stress. J Endocrinol. 2009;202:263-78 pubmed publisher
    ..To accomplish this, naturally AVP-deficient Brattleboro rats were exposed to a wide range of stimuli and their HPA response was compared with heterozygous littermates...
  45. Del Tredici A, Vanover K, Knapp A, Bertozzi S, Nash N, Burstein E, et al. Identification of novel selective V2 receptor non-peptide agonists. Biochem Pharmacol. 2008;76:1134-41 pubmed publisher
    ..Thus, AC-94544, AC-88324, and AC-110484 represent novel opportunities for the treatment of disorders associated with V(2) receptor agonist deficiency...
  46. Khegay I, Popova N, Ivanova L. Reduced Walker 256 carcinosarcoma growth in vasopressin-deficient Brattleboro rats. Tumour Biol. 2010;31:569-73 pubmed publisher
    ..The Brattleboro rats are unable to synthesize vasopressin in a consequence of deletion in the coding gene...
  47. Khegai I. [Interaction of the diabetes insipidus locus alleles with the renal 120 kDa protein-encoding gene in rat development]. Genetika. 2003;39:397-401 pubmed
    Age-dependant dynamics of the kidney inner medullary 120-kDa protein content in vasopressin-deficient Brattleboro rats with di/di mutant genotype was studied in comparison with WAG rats with genotype and normal vasopressin expression...
  48. Gardiner S, Kemp P, Bennett T. Effects of chronic treatment with nitric oxide synthase inhibitors on regional haemodynamic responses to vasodilators in conscious Brattleboro rats. Br J Pharmacol. 1993;109:222-8 pubmed
    ..We now report the responses to vasodilators during and after chronic NO synthase inhibition. 2. In conscious Brattleboro rats, the regional haemodynamic effects of 3 min infusions of acetylcholine (4 micrograms min-1), sodium ..
  49. Schank J. Early locomotor and social effects in vasopressin deficient neonatal rats. Behav Brain Res. 2009;197:166-77 pubmed publisher
    ..These behavioral metrics are generalizable to infants of other rodent species and thus may allow early behavioral phenotyping and the assessment of behavioral deficits...
  50. Li C, Wang W, Summer S, Westfall T, Brooks D, Falk S, et al. Molecular mechanisms of antidiuretic effect of oxytocin. J Am Soc Nephrol. 2008;19:225-32 pubmed
    ..We infused oxytocin by osmotic minipump into vasopressin-deficient Brattleboro rats for five days and observed marked antidiuresis, increased urine osmolality, and increased solute-free water ..
  51. Toba K, Ouchi Y, Liang J, Akishita M, Orimo H. Role of central vasopressin in cardiovascular regulation: effect of dehydration and sex. Gerontology. 1994;40 Suppl 2:16-22 pubmed
    ..Second, vasopressin was intracerebroventricularly injected in male and female homozygous Brattleboro rats. The increase in MABP was greater in males than in females...
  52. Inoue T, Terris J, Ecelbarger C, Chou C, Nielsen S, Knepper M. Vasopressin regulates apical targeting of aquaporin-2 but not of UT1 urea transporter in renal collecting duct. Am J Physiol. 1999;276:F559-66 pubmed
    ..Immunoperoxidase labeling of inner medullary thin sections from Brattleboro rats treated with 1-desamino-8-D-arginine vasopressin (DDAVP) for 20 min revealed dramatic translocation of AQP2 ..
  53. Hoffert J, Fenton R, Moeller H, Simons B, Tchapyjnikov D, McDill B, et al. Vasopressin-stimulated increase in phosphorylation at Ser269 potentiates plasma membrane retention of aquaporin-2. J Biol Chem. 2008;283:24617-27 pubmed publisher
    ..The data support a model in which vasopressin-mediated phosphorylation of AQP2 at Ser269:(a) depends on prior PKA-mediated phosphorylation of Ser256 and (b) enhances apical plasma membrane retention of AQP2...
  54. Morales M, Nascimento D, Capella M, Lopes A, Guggino W. Arginine vasopressin regulates CFTR and ClC-2 mRNA expression in rat kidney cortex and medulla. Pflugers Arch. 2001;443:202-11 pubmed
    ..of these chloride channels we studied Wistar rats subjected to dehydration for 2 days and also the homozygous Brattleboro rats, a strain of Long-Evans rats carrying an autosomal recessive mutation that leads to a deficiency of arginine-..
  55. Idbaih A, Burlet A, Adle Biassette H, Boisgard R, Coulon C, Paris S, et al. Altered cerebral glucose metabolism in an animal model of diabetes insipidus: a micro-PET study. Brain Res. 2007;1158:164-8 pubmed
    ..We studied brain glucose uptake, a marker of neuronal activity, in 6 Brattleboro rats, in comparison with 6 matched Long-Evans (LE) control rats...
  56. Van Hoek A, Bouley R, Lu Y, Silberstein C, Brown D, Wax M, et al. Vasopressin-induced differential stimulation of AQP4 splice variants regulates the in-membrane assembly of orthogonal arrays. Am J Physiol Renal Physiol. 2009;296:F1396-404 pubmed publisher
    ..Because the higher-order organization of AQP4 was perturbed by vasopressin in Brattleboro rats and phosphorylation sites have been identified on AQP4, we investigated whether vasopressin and forskolin (Fk)..
  57. Russo L, McKee M, Brown D. Methyl-beta-cyclodextrin induces vasopressin-independent apical accumulation of aquaporin-2 in the isolated, perfused rat kidney. Am J Physiol Renal Physiol. 2006;291:F246-53 pubmed
    ..001). Similar changes were observed following mbetaCD perfusion of kidneys from vasopressin-deficient Brattleboro rats. No effect of mbetaCD treatment on the basolateral distribution of AQP3 and AQP4 was detected...
  58. Zelena D, Barna I, Csabai K, Orlando G, Makara G, Engelmann M. Response of the adrenomedullary system to early postnatal stress in the Brattleboro rat. Ann N Y Acad Sci. 2008;1148:456-61 pubmed publisher
    ..Furthermore, our results imply that the congenital absence of AVP affects the synthesis of PNMT in response to defined stressor exposure...
  59. Sharova N, Melnikova V, Khegai I, Karpovaa Y, Dmitrieva S, Astakhova T, et al. Pattern of proteasome expression in Walker 256 tumor cells after their transplantation into the Brattleboro rats with genetic defect of vasopressin synthesis. Dokl Biochem Biophys. 2008;419:93-7 pubmed
  60. Feifel D, Mexal S, Melendez G, Liu P, Goldenberg J, Shilling P. The brattleboro rat displays a natural deficit in social discrimination that is restored by clozapine and a neurotensin analog. Neuropsychopharmacology. 2009;34:2011-8 pubmed publisher
    ..The potential of neurotensin agonists as putative treatments for cognitive deficits of schizophrenia was also supported...
  61. Kotnik P, Nielsen J, Kwon T, Krzisnik C, Frøkiaer J, Nielsen S. Altered expression of COX-1, COX-2, and mPGES in rats with nephrogenic and central diabetes insipidus. Am J Physiol Renal Physiol. 2005;288:F1053-68 pubmed
    ..These results identify markedly reduced expression of COX-1, COX-2, and mPGES in IM in lithium-induced NDI. Furthermore, there were major changes in the expression of COX-1, COX-2, and mPGES in rats with CDI...
  62. Gardiner S, Bennett T. Cardiovascular consequences of water deprivation in female Long Evans and Brattleboro rats. J Auton Nerv Syst. 1988;24:205-14 pubmed
    Female Long Evans and Brattleboro rats were studied while water-replete and after water deprivation sufficient to cause hypovolaemia of similar degree in the two strains...
  63. Hazon N, Parker C, Leonard R, Henderson I. Influence of an enriched dietary sodium chloride regime during gestation and suckling and post-natally on the ontogeny of hypertension in the rat. J Hypertens. 1988;6:517-24 pubmed
    b>Brattleboro rats without diabetes insipidus were subjected to sodium chloride enrichment (20-fold increase in dietary salt) at various stages of their development...
  64. Schmale H, Ivell R, Breindl M, Darmer D, Richter D. The mutant vasopressin gene from diabetes insipidus (Brattleboro) rats is transcribed but the message is not efficiently translated. EMBO J. 1984;3:3289-93 pubmed
    ..Blot analysis of hypothalamic RNA as well as transfection and microinjection experiments indicate that the mutant gene is correctly transcribed and spliced, however the resulting mRNA is not efficiently translated...
  65. Acher R, Chauvet J, Rouille Y. Dynamic processing of neuropeptides: sequential conformation shaping of neurohypophysial preprohormones during intraneuronal secretory transport. J Mol Neurosci. 2002;18:223-8 pubmed
    ..In the homozygote mutant Brattleboro rats, a single nucleotide deletion in the gene entails a complete change in aminoacid sequence of neurophysin from ..
  66. Christensen B, Wang W, Frøkiaer J, Nielsen S. Axial heterogeneity in basolateral AQP2 localization in rat kidney: effect of vasopressin. Am J Physiol Renal Physiol. 2003;284:F701-17 pubmed
    ..cells and inner medullary collecting duct (IMCD) principal cells in normal rats and vasopressin-deficient Brattleboro rats. In contrast there was little basolateral AQP2 labeling in cortical (CCD) and outer medullary collecting duct ..
  67. Mutig K, Paliege A, Kahl T, Jöns T, Muller Esterl W, Bachmann S. Vasopressin V2 receptor expression along rat, mouse, and human renal epithelia with focus on TAL. Am J Physiol Renal Physiol. 2007;293:F1166-77 pubmed
    ..Strong V(2)R expression in macula densa may be related to tubulovascular signal transfer...
  68. Mohr E, Peters A, Morris J, Richter D. Somatic nonhomologous crossing-over between neuropeptide genes in rat hypothalamic neurons. Proc Natl Acad Sci U S A. 1994;91:11403-7 pubmed
    ..Recombination appears to be a rather frequent genetic event affecting about 0.06-0.1% of the rat vasopressinergic magnocellular neurons in aged rats...
  69. Ma D, Morris J. Protein synthetic machinery in the dendrites of the magnocellular neurosecretory neurons of wild-type Long-Evans and homozygous Brattleboro rats. J Chem Neuroanat. 2002;23:171-86 pubmed
    ..The results provide morphological evidence that magnocellular dendrites have the capacity for local protein syntheses and that this is increased in chronic hyperosmotic stress...
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    ..DOCA treatment of normal control rats, but the response was blunted in rats fed a low-salt diet and absent in Brattleboro rats. DOCA treatment of mouse renal medullary interstitial cells in culture had no effect, but increased tonicity ..
  71. Banafsche R, Keck T, Diener M, Gebhard M, Klar E. Desmopressin impairs hepatic microcirculation: impact on liver graft quality. Transplant Proc. 2002;34:2310-1 pubmed
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    ..Compared with a widely used commercial software tool, QUIL showed improvement in ion chromatogram construction and peak integration and significantly reduced relative errors in abundance ratio assessment. ..
  73. Khegai I, Popova N, Ivanova L. [Effect of vasopressin gene expression on the growth of Walker 256 carcinosarcoma in rats]. Genetika. 2006;42:993-5 pubmed
    ..In contrast to the vasopressin gene of normal WA rats, that of mutant Brattleboro rats has a deletion in the coding region that blocks expression at the translation level...
  74. Yang Z, Coote J. Paraventricular nucleus influence on renal sympathetic activity in vasopressin gene-deleted rats. Exp Physiol. 2007;92:109-17 pubmed
    ..The present study examines this in Brattleboro rats, which have a natural vasopressin gene deletion...
  75. Levy J, Stevens W. Plasma hyperosmolality stimulates leptin secretion acutely by a vasopressin-adrenal mechanism. Am J Physiol Endocrinol Metab. 2004;287:E263-8 pubmed
    ..In conclusion, intravenous infusions of hypertonic glucose and hypertonic mannitol independently stimulate leptin secretion. Hyperosmolality stimulates leptin secretion by a vasopressin-adrenal mechanism...
  76. Silberstein C, Bouley R, Huang Y, Fang P, Pastor Soler N, Brown D, et al. Membrane organization and function of M1 and M23 isoforms of aquaporin-4 in epithelial cells. Am J Physiol Renal Physiol. 2004;287:F501-11 pubmed
  77. Kondo K, Kan K, Tanada Y, Bando M, Shinohara T, Kurimura M, et al. Characterization of orally active nonpeptide vasopressin V(2) receptor agonist. Synthesis and biological evaluation of both the (5R)- and (5S)-enantioisomers of 2-[1-(2-Chloro-4-pyrrolidin-1-yl-benzoyl)-2,3,4,5-tetrahydro-1H-1-benzazepin- 5-yl]-N-iso. J Med Chem. 2002;45:3805-8 pubmed
    ..After evaluation of both enantiomers (compounds R-2, S-2) for binding affinity, cAMP accumulation, and an in vivo study using Brattleboro rats, R-2 showed more potent activity as a V(2) receptor agonist than S-2.
  78. Petrovic S, Amlal H, Sun X, Karet F, Barone S, Soleimani M. Vasopressin induces expression of the Cl-/HCO3- exchanger SLC26A7 in kidney medullary collecting ducts of Brattleboro rats. Am J Physiol Renal Physiol. 2006;290:F1194-201 pubmed
    ..of the present experiments was to examine the expression of SLC26A7 in kidneys of vasopressin-deficient Brattleboro rats before and after treatment with desamino-Cys(1),d-Arg(8)-vasopressin (dDAVP)...
  79. Nicco C, Wittner M, DiStefano A, Jounier S, Bankir L, Bouby N. Chronic exposure to vasopressin upregulates ENaC and sodium transport in the rat renal collecting duct and lung. Hypertension. 2001;38:1143-9 pubmed
    ..Five-day infusion of dDAVP (a V(2) receptor agonist) to Brattleboro rats lacking vasopressin induced a marked increase in beta- and gamma-subunit ENaC mRNA levels in the renal cortex ..
  80. Khegai I. [Effect of the di mutation (non-sugar diabetes) on properties of kidney proteins in rats]. Genetika. 2000;36:853-5 pubmed
    Renal proteins were studied in Brattleboro rats of the didi genotype and in Wistar and Sprague-Dawley rats with normal alleles +2 of this loci...
  81. Khegai I. [Reaction of alpha-actinin from renal inner medulla on prolonged dehydration]. Ross Fiziol Zh Im I M Sechenova. 2004;90:1563-6 pubmed
    ..It was 57.5+/-4.6 in hydrated animals, and statistically lower in rats being under 3-day water deprivation--26.4+/-5.7 in relative units of protein...
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  83. Gardiner S, Compton A, Bennett T. Regional hemodynamic changes following hypovolemia in conscious rats. Am J Physiol. 1989;256:R1076-83 pubmed Long-Evans rats; 4-5 h after PEG the mesenteric vasoconstriction was greater in Long-Evans than in Brattleboro rats, but the renal and hindquarters vasoconstrictions were similar in both strains...