mutant strains rats


Summary: Rats bearing mutant genes which are phenotypically expressed in the animals.

Top Publications

  1. Ueda S, Sakakibara S, Nakadate K, Noda T, Shinoda M, Joyce J. Degeneration of dopaminergic neurons in the substantia nigra of zitter mutant rat and protection by chronic intake of Vitamin E. Neurosci Lett. 2005;380:252-6 pubmed
    ..Thus, the zitter rat may represent a good model for studying the dopaminergic cell death by superoxide species...
  2. Matsuoka M, Ogata N, Minamino K, Higuchi A, Matsumura M. High levels of pigment epithelium-derived factor in the retina of a rat model of type 2 diabetes. Exp Eye Res. 2006;82:172-8 pubmed
    ..The high levels of PEDF in the retina of SDT rats may contribute to the low incidence of neovascular formation and absence of non-perfused areas that do not match the typical diabetic retinopathy in humans...
  3. Pfab T, Thone Reineke C, Theilig F, Lange I, Witt H, Maser Gluth C, et al. Diabetic endothelin B receptor-deficient rats develop severe hypertension and progressive renal failure. J Am Soc Nephrol. 2006;17:1082-9 pubmed
    ..The study demonstrates for the first time that the combination of diabetes and ETBR deficiency causes severe low-renin hypertension with progressive renal failure...
  4. Nakadate K, Noda T, Sakakibara S, Kumamoto K, Matsuura T, Joyce J, et al. Progressive dopaminergic neurodegeneration of substantia nigra in the zitter mutant rat. Acta Neuropathol. 2006;112:64-73 pubmed
    ..Moreover, ubiquitin-immunohistochemical analysis indicated that the accumulation of products of the endosomal-lysosomal system may be involved in this degeneration...
  5. Kadowaki T, Nakadate K, Sakakibara S, Hirata K, Ueda S. Expression of Iba1 protein in microglial cells of zitter mutant rat. Neurosci Lett. 2007;411:26-31 pubmed
    ..The present data may thus suggest that microglial cells directly or indirectly contribute to progressive spongy degeneration in zitter mutant rats...
  6. Matsui K, Ohta T, Oda T, Sasase T, Ueda N, Miyajima K, et al. Diabetes-associated complications in Spontaneously Diabetic Torii fatty rats. Exp Anim. 2008;57:111-21 pubmed
    ..In conclusion, the SDT fatty rat is expected to be a useful model for the analysis of diabetic complications and the evaluation of drugs related to metabolic diseases...
  7. Yokoi N, Komeda K, Wang H, Yano H, Kitada K, Saitoh Y, et al. Cblb is a major susceptibility gene for rat type 1 diabetes mellitus. Nat Genet. 2002;31:391-4 pubmed
    ..Impairment of the Cblb signaling pathway may contribute to human autoimmune diseases, including type 1 diabetes...
  8. Ueda S, Sakakibara S, Watanabe E, Yoshimoto K, Koibuchi N. Vulnerability of monoaminergic neurons in the brainstem of the zitter rat in oxidative stress. Prog Brain Res. 2002;136:293-302 pubmed
    ..The degeneration of DA cell bodies and fibers was characterized by swollen varicosities and clustered fibers...
  9. Kuwamura M, Maeda M, Kuramoto T, Kitada K, Kanehara T, Moriyama M, et al. The myelin vacuolation (mv) rat with a null mutation in the attractin gene. Lab Invest. 2002;82:1279-86 pubmed
    ..Discovery of the rat null mutation Atrn(mv), different from Atrn(zi), provides a new animal model for studying the functions of the attractin protein...

More Information

Publications111 found, 100 shown here

  1. McDorman K, Wolf D. Use of the spontaneous Tsc2 knockout (Eker) rat model of hereditary renal cell carcinoma for the study of renal carcinogens. Toxicol Pathol. 2002;30:675-80 pubmed
    ..The quantitative nature of the model allows for the production of statistically powerful data to understand the relative degree and potency of chemical effects and allow analysis of genetic alterations that may be chemical specific...
  2. Habib S, Phan M, Patel S, Li D, Monks T, Lau S. Reduced constitutive 8-oxoguanine-DNA glycosylase expression and impaired induction following oxidative DNA damage in the tuberin deficient Eker rat. Carcinogenesis. 2003;24:573-82 pubmed
    ..In keeping with this view, acute TGHQ-induced cytotoxicity was greater in Tsc-2(EK/+) rats than in Tsc-2(+/+) rats. The mechanism(s) coupling tuberin expression to the regulation of OGG1 are not known and are under investigation...
  3. Irani B, Dunn Meynell A, Levin B. Altered hypothalamic leptin, insulin, and melanocortin binding associated with moderate-fat diet and predisposition to obesity. Endocrinology. 2007;148:310-6 pubmed
    ..These results corroborate our previous findings demonstrating a preexisting decrease in DIO hypothalamic leptin and insulin signaling and demonstrate that HE diet intake reduces hypothalamic melanocortin and hippocampal insulin binding. ..
  4. Gironi Carnevale U, Vitullo E, Varriale B, Ruocco L, Sadile A. A classical Mendelian cross-breeding study of the Naples high and low excitability rat lines. Behav Brain Res. 2007;183:130-40 pubmed
    ..Moreover, HA and VA activity components with prevailing cognitive and non-cognitive meaning, respectively, show differential genetic control. ..
  5. Wang S, Lu B, Girman S, Holmes T, Bischoff N, Lund R. Morphological and functional rescue in RCS rats after RPE cell line transplantation at a later stage of degeneration. Invest Ophthalmol Vis Sci. 2008;49:416-21 pubmed publisher
    ..RPE cell line transplants delivered later in the course of degeneration can preserve not only the photoreceptors and inner retinal lamination but also visual function in RCS rats. However, early intervention can achieve better rescue. ..
  6. Ouyang G, Li X, Dang C, Richards D. Using recurrence plot for determinism analysis of EEG recordings in genetic absence epilepsy rats. Clin Neurophysiol. 2008;119:1747-55 pubmed publisher
  7. Ando H, Ushijima K, Yanagihara H, Hayashi Y, Takamura T, Kaneko S, et al. Clock gene expression in the liver and adipose tissues of non-obese type 2 diabetic Goto-Kakizaki rats. Clin Exp Hypertens. 2009;31:201-7 pubmed publisher
    ..Our results suggest that molecular clock impairment in peripheral tissues of obese diabetic animals may be either caused by obesity-related factor(s), but not hyperglycemia, or be a cause, but not a consequence, of hyperglycemia. ..
  8. Andjus P, Bajić A, Zhu L, Schachner M, Strata P. Short-term facilitation and depression in the cerebellum: some observations on wild-type and mutant rodents deficient in the extracellular matrix molecule tenascin C. Ann N Y Acad Sci. 2005;1048:185-97 pubmed
    ..The results underline differences in forms of short-term plasticity with regard to susceptibility to diverse modulatory factors. ..
  9. Liu K, Lo M, Benzoni D. Effect of perindopril on renal medullary hemodynamics in genetically hypertensive rats. Am J Hypertens. 2006;19:617-22 pubmed
    ..Chronic ACE inhibition restores the vasodilator response of MBF to Ang II in LH rats. This effect, which is not observed after acute inhibition, is mainly mediated through the release of prostaglandins. ..
  10. Schirmer M, Lessenich A, Lindemann S, Loscher W. Marked differences in response to dopamine receptor antagonism in two rat mutants, ci2 and ci3, with lateralized rotational behavior. Behav Brain Res. 2007;180:218-25 pubmed
    ..The comparative evaluation of these two rat mutants may help to increase our understanding of the relationship between developmental anomalies of cerebral asymmetry and brain disorders. ..
  11. Shin E, Ko K, Kim W, Chae J, Yen T, Kim H, et al. Role of glutathione peroxidase in the ontogeny of hippocampal oxidative stress and kainate seizure sensitivity in the genetically epilepsy-prone rats. Neurochem Int. 2008;52:1134-47 pubmed publisher
    ..These responses were more pronounced in control SD rats than in GEPR-9s. Our results suggest that impairment of the GPx (including glutathione)-mediated antioxidant system contributed to epileptogenesis in GEPR-9s. ..
  12. Cottone P, Sabino V, Nagy T, Coscina D, Zorrilla E. Feeding microstructure in diet-induced obesity susceptible versus resistant rats: central effects of urocortin 2. J Physiol. 2007;583:487-504 pubmed
    ..Because central CRF(2) stimulation retains full anorectic efficacy at higher doses in the DIO model, manipulating this neuropeptidergic system might yield new therapeutic approaches for diet-induced obesity. ..
  13. Abdourahman A, Edwards J. Chromium supplementation improves glucose tolerance in diabetic Goto-Kakizaki rats. IUBMB Life. 2008;60:541-8 pubmed publisher
  14. Zhang L, Lichtmannegger J, Summer K, Webb S, Pickering I, George G. Tracing copper-thiomolybdate complexes in a prospective treatment for Wilson's disease. Biochemistry. 2009;48:891-7 pubmed publisher
    ..Our work allows new insights into metabolism of the metal complex in the diseased state. ..
  15. Jian Q, Xu H, Xie H, Tian C, Zhao T, Yin Z. Activation of retinal stem cells in the proliferating marginal region of RCS rats during development of retinitis pigmentosa. Neurosci Lett. 2009;465:41-4 pubmed publisher
    ..These results suggest that RSCs in the mammalian retinal proliferating marginal regions has the potential to regenerate following degeneration. ..
  16. Sawamura D, Abe R, Goto M, Akiyama M, Hemmi H, Akira S, et al. Direct injection of plasmid DNA into the skin induces dermatitis by activation of monocytes through toll-like receptor 9. J Gene Med. 2005;7:664-71 pubmed
    ..We should therefore attempt to counteract this dermatitis during the clinical use of the naked DNA injection method in skin. ..
  17. Yasuda K, Aoki N, Adachi T, Tsujimoto G, Gu N, Matsunaga T, et al. Hyperbaric exposure with high oxygen concentration inhibits growth-associated increase in the glucose level of diabetic Goto-Kakizaki rats. Diabetes Obes Metab. 2006;8:714-5 pubmed
  18. Shinde J, Taldone T, Barletta M, Kunaparaju N, Hu B, Kumar S, et al. Alpha-glucosidase inhibitory activity of Syzygium cumini (Linn.) Skeels seed kernel in vitro and in Goto-Kakizaki (GK) rats. Carbohydr Res. 2008;343:1278-81 pubmed publisher
    ..Therefore, these results point to the inhibition of alpha-glucosidase as a possible mechanism by which this herb acts as an anti-diabetic agent. ..
  19. Vugler A, Carr A, Lawrence J, Chen L, Burrell K, Wright A, et al. Elucidating the phenomenon of HESC-derived RPE: anatomy of cell genesis, expansion and retinal transplantation. Exp Neurol. 2008;214:347-61 pubmed publisher
    ..The presence of rhodopsin-positive material within grafted HESC-RPE indicates that in the future, homogenous transplants of this cell type may be capable of supporting visual function following retinal dystrophy. ..
  20. Oruckaptan H, Ozisik P, Atilla P, Tuncel M, Kilinc K, Geyik P, et al. Systemic administration of interleukin-10 attenuates early ischemic response following spinal cord ischemia reperfusion injury in rats. J Surg Res. 2009;155:345-56 pubmed publisher
    ..Anti-IL-1beta has no considerable effect in this time window. The results of this preliminary study promote further studies with longer time windows on the effects of anti-inflammatory cytokines in spinal cord IRI. ..
  21. Suzuki H, Katayama K, Takenaka M, Amakasu K, Saito K, Suzuki K. A spontaneous mutation of the Wwox gene and audiogenic seizures in rats with lethal dwarfism and epilepsy. Genes Brain Behav. 2009;8:650-60 pubmed publisher
    ..The lde/lde rat is not only useful for understanding the multiple functions of Wwox but is also a unique model for studying the physiological function of Wwox in CNS...
  22. Ishimaru Y, Chiba S, Serikawa T, Sasa M, Inaba H, Tamura Y, et al. Effects of levetiracetam on hippocampal kindling in Noda epileptic rats. Brain Res. 2010;1309:104-9 pubmed publisher
    ..Furthermore, LEV may have inhibitory effects not only on the hippocampus but also on other neuronal pathways to secondary generalization in this rat model. ..
  23. Hanaya R, Sasa M, Sugata S, Tokudome M, Serikawa T, Kurisu K, et al. Hippocampal cell loss and propagation of abnormal discharges accompanied with the expression of tonic convulsion in the spontaneously epileptic rat. Brain Res. 2010;1328:171-80 pubmed publisher
    ..Repetitive tonic seizures and vulnerable CA3 neurons of SER could be involved in the induction of sclerosis-like changes in the hippocampus. ..
  24. Girman S, Wang S, Lund R. Time course of deterioration of rod and cone function in RCS rat and the effects of subretinal cell grafting: a light- and dark-adaptation study. Vision Res. 2005;45:343-54 pubmed
    ..This raises concern that measures of outer nuclear layer thickness may not in themselves be an accurate measure of visual capabilities and efficacy of a restoration strategy. ..
  25. Paz J, Deniau J, Charpier S. Rhythmic bursting in the cortico-subthalamo-pallidal network during spontaneous genetically determined spike and wave discharges. J Neurosci. 2005;25:2092-101 pubmed
    ..The repetitive discharges in STN neurons accompanying absence seizures might convey powerful excitation to basal ganglia output nuclei and, consequently, may participate in the control of thalamocortical SWDs. ..
  26. Chen Y, Ohmori K, Mizukawa M, Yoshida J, Zeng Y, Zhang L, et al. Differential impact of atorvastatin vs pravastatin on progressive insulin resistance and left ventricular diastolic dysfunction in a rat model of type II diabetes. Circ J. 2007;71:144-52 pubmed
  27. Hirasugi K, Hisa Y, Setsu T, Terashima T. Ambiguus motoneurons innervating laryngeal and esophageal muscles are malpositioned in the Reelin-deficient mutant rat, Shaking Rat Kawasaki. Acta Otolaryngol. 2007;127:213-20 pubmed
  28. Yasoshima M, Sato Y, Furubo S, Kizawa K, Sanzen T, Ozaki S, et al. Matrix proteins of basement membrane of intrahepatic bile ducts are degraded in congenital hepatic fibrosis and Caroli's disease. J Pathol. 2009;217:442-51 pubmed publisher
  29. Eguibar J, Côrtes M, Ita M. Serotonergic-postsynaptic receptors modulate gripping-induced immobility episodes in male taiep rats. Synapse. 2009;63:737-44 pubmed publisher
    ..It is possible that specific agonists, without side effects, could be a useful treatment in human narcoleptic patients. ..
  30. Raisinghani M, Faingold C. Neurons in the amygdala play an important role in the neuronal network mediating a clonic form of audiogenic seizures both before and after audiogenic kindling. Brain Res. 2005;1032:131-40 pubmed
  31. Polack P, Charpier S. Intracellular activity of cortical and thalamic neurones during high-voltage rhythmic spike discharge in Long-Evans rats in vivo. J Physiol. 2006;571:461-76 pubmed
    ..Thus, the present study provides an additional support to the hypothesis that HVRS activity in Long-Evans rats is an absence-like seizure activity. ..
  32. Gómez J, Gunnerson K, Song M, Li J, Kellum J. Effects of hypercapnia on BP in hypoalbuminemic and Nagase analbuminemic rats. Chest. 2007;131:1295-300 pubmed
    ..Baseline values for apparent strong ion difference are lower in NA rats consistent with a reduced buffer base resulting from analbuminemia. ..
  33. Viapiano M, Hockfield S, Matthews R. BEHAB/brevican requires ADAMTS-mediated proteolytic cleavage to promote glioma invasion. J Neurooncol. 2008;88:261-72 pubmed publisher
    ..In addition, our findings underscore the relevance of the ADAMTS family of metalloproteases as attractive targets for novel pharmacological approaches in glioma therapy. ..
  34. Shen W, Hao J, Tian C, Ren J, Yang L, Li X, et al. A combination of nutriments improves mitochondrial biogenesis and function in skeletal muscle of type 2 diabetic Goto-Kakizaki rats. PLoS ONE. 2008;3:e2328 pubmed publisher
    ..These data suggest that a combination of mitochondrial targeting nutrients may improve skeletal mitochondrial dysfunction and exert hypoglycemic effects, without causing weight gain. ..
  35. Zhang M, Mo X, Fang Y, Guo W, Wu J, Zhang S, et al. Rescue of photoreceptors by BDNF gene transfer using in vivo electroporation in the RCS rat of retinitis pigmentosa. Curr Eye Res. 2009;34:791-9 pubmed
    ..These findings provide evidence that electroporation is an effective method for gene transfer into retinal pigment epithelial cells, and the rescue of photoreceptors can be achieved by BDNF gene transfection with electroporation. ..
  36. Stefanova N, Fursova A, Kolosova N. Behavioral effects induced by mitochondria-targeted antioxidant SkQ1 in Wistar and senescence-accelerated OXYS rats. J Alzheimers Dis. 2010;21:479-91 pubmed publisher
    ..Nevertheless, SkQ1 did not alter learning performance in the MWM in OXYS rats and slightly reduced it in the Wistar strain, which may be associated with differences in redox homeostasis. ..
  37. Nagai N, Takeuchi N, Kamei A, Ito Y. Involvement of DNase II-like acid DNase in the cataract formation of the UPL rat and the Shumiya cataract rat. Biol Pharm Bull. 2006;29:2367-71 pubmed
    ..It is possible that UPLRs are a good model for cataract caused by a decrease of DNA degradation in the lenses. ..
  38. Tokuda S, Kuramoto T, Tanaka K, Kaneko S, Takeuchi I, Sasa M, et al. The ataxic groggy rat has a missense mutation in the P/Q-type voltage-gated Ca2+ channel alpha1A subunit gene and exhibits absence seizures. Brain Res. 2007;1133:168-77 pubmed
    ..Thus, the GRY rat with P/Q-type Ca(2+) channel disorders is a useful model for studying absence epilepsy and Cacna1a-related diseases. ..
  39. Mattson D, Kunert M, Roman R, Jacob H, Cowley A. Substitution of chromosome 1 ameliorates L-NAME hypertension and renal disease in the fawn-hooded hypertensive rat. Am J Physiol Renal Physiol. 2005;288:F1015-22 pubmed
    ..Qualitatively similar results were obtained from female FHH, FHH-1BN, and BN rats. The present results indicate that genes contributing to l-NAME-induced hypertension and renal disease are found on chromosome 1 of the FHH rat. ..
  40. He X, Sullivan E, Stankovic R, Harper C, Pfefferbaum A. Interaction of thiamine deficiency and voluntary alcohol consumption disrupts rat corpus callosum ultrastructure. Neuropsychopharmacology. 2007;32:2207-16 pubmed
  41. Sakai T, Kuno N, Takamatsu F, Kimura E, Kohno H, Okano K, et al. Prolonged protective effect of basic fibroblast growth factor-impregnated nanoparticles in royal college of surgeons rats. Invest Ophthalmol Vis Sci. 2007;48:3381-7 pubmed
    ..This novel drug delivery system for bFGF may serve as a potential short-term treatment for photoreceptor degeneration in humans. ..
  42. Clerk L, Vincent M, Barrett E, Lankford M, Lindner J. Skeletal muscle capillary responses to insulin are abnormal in late-stage diabetes and are restored by angiotensin-converting enzyme inhibition. Am J Physiol Endocrinol Metab. 2007;293:E1804-9 pubmed
    ..We conclude that insulin-mediated capillary recruitment in skeletal muscle, which participates in glucose utilization, is impaired in animals with DM and can be partially reversed by chronic ACE-I therapy. ..
  43. Peng C, Sankaran D, Ogborn M, Aukema H. Dietary soy protein selectively reduces renal prostanoids and cyclooxygenases in polycystic kidney disease. Exp Biol Med (Maywood). 2009;234:737-43 pubmed publisher
    ..Dietary soy protein therefore reduced the levels of specific renal prostanoids, cPLA(2) and COX enzymes in this model of polycystic kidney disease, a model in which soy protein has been demonstrated to reduce disease progression. ..
  44. Pinilla I, Cuenca N, Martinez Navarrete G, Lund R, Sauve Y. Intraretinal processing following photoreceptor rescue by non-retinal cells. Vision Res. 2009;49:2067-77 pubmed publisher
    ..Since Schwann cells have no phagocytic properties, their therapeutic effect is best explained through a paracrine mechanism (secretion of factors that ensure photoreceptor survival). ..
  45. Yeom S, Kim G, Kim C, Jung H, Kim S, Park J, et al. Regulation of insulin secretion and beta-cell mass by activating signal cointegrator 2. Mol Cell Biol. 2006;26:4553-63 pubmed
    ..These results suggest that ASC-2 regulates insulin secretion and beta-cell survival and that the regulatory role of ASC-2 in insulin secretion appears to involve, at least in part, its interaction with NRs via its two NR boxes. ..
  46. Jamali R, Mohseni S. Differential neuropathies in hyperglycemic and hypoglycemic diabetic rats. J Neuropathol Exp Neurol. 2006;65:1118-25 pubmed
    ..We conclude that hypoglycemia has a more severe impact on somatic motor nerves than on somatic sensory nerves, whereas hyperglycemia affects only somatic sensory nerves. ..
  47. Ostenson C, Chen J, Sheu L, Gaisano H. Effects of palmitate on insulin secretion and exocytotic proteins in islets of diabetic Goto-Kakizaki rats. Pancreas. 2007;34:359-63 pubmed
    ..These results were different from prolonged glucose treatment we previously reported, indicating differences between glucotoxic and lipotoxic actions on the insulin secretory machinery. ..
  48. Sachidanandam K, Portik Dobos V, Harris A, Hutchinson J, Muller E, Johnson M, et al. Evidence for vasculoprotective effects of ETB receptors in resistance artery remodeling in diabetes. Diabetes. 2007;56:2753-8 pubmed
    ..ET-1 contributes to the remodeling of mesenteric resistance arteries in diabetes via activation of ET(A) receptors, and ET(B) receptors provide vasculoprotective effects. ..
  49. Kouchi M, Okimoto K, Matsumoto I, Michimae Y, Yamada T, Inoue T, et al. Postoperative fibromatosis-type fibromas in the Bhd gene mutant (Nihon) rat. Exp Toxicol Pathol. 2008;59:273-9 pubmed
    ..Genetic factor should be involved in the occurrence of the tumor, since it was found only in the Nihon rats among many rats. Our present data suggest that Bhd gene mutation is not likely to be a candidate. ..
  50. Hamson D, Csupity A, Gaspar J, Watson N. Analysis of Foxp2 expression in the cerebellum reveals a possible sex difference. Neuroreport. 2009;20:611-6 pubmed publisher
    ..These data suggest a sex difference in Foxp2 expression in the cerebellum. ..
  51. Muto S, Monnai M, Okuhara Y, Murakami M, Kuroda J, Ono T, et al. Altered cytokine expression in mesenteric lymph nodes in a rat strain (Matsumoto Eosinophilic Shinshu) that spontaneously develops hypereosinophilia. Immunology. 2005;116:373-80 pubmed
  52. Ramirez R, Hubel C, Novak J, DiCianno J, Kagan V, Gandley R. Moderate ascorbate deficiency increases myogenic tone of arteries from pregnant but not virgin ascorbate-dependent rats. Hypertension. 2006;47:454-60 pubmed
    ..This increase may result from a decrease in nitric oxide-mediated modulation of the myogenic contractile response...
  53. Nagao S, Nishii K, Katsuyama M, Kurahashi H, Marunouchi T, Takahashi H, et al. Increased water intake decreases progression of polycystic kidney disease in the PCK rat. J Am Soc Nephrol. 2006;17:2220-7 pubmed
    ..It is suggested that limiting serum AVP levels by increased water intake may be beneficial to some patients with PKD...
  54. Godlevsky L, Vostrov G, Kobolev E, van Luijtelaar E, Coenen A, Iorhachova M, et al. Are there different mechanisms of synchronization in the course of spike-wave discharges (SWDs) burst development in WAG/Rij rats?. Acta Neurobiol Exp (Wars). 2006;66:189-94 pubmed
    ..Paleocerebellum correlates at a weak to moderate level during different periods of SWD burst generation...
  55. Takenaka M, Yagi M, Amakasu K, Suzuki K, Suzuki H. Retarded differentiation of Leydig cells and increased apoptosis of germ cells in the initial round of spermatogenesis of rats with lethal dwarf and epilepsy (lde/lde) phenotypes. J Androl. 2008;29:669-78 pubmed publisher
    ..Because lde/lde rats experience epileptic seizures during the period when the hypothalamus-pituitary-testicular axis is established, lde/lde rats would be useful as a model for reproductive disorder with pediatric epilepsy...
  56. Tomita H, Sugano E, Isago H, Hiroi T, Wang Z, Ohta E, et al. Channelrhodopsin-2 gene transduced into retinal ganglion cells restores functional vision in genetically blind rats. Exp Eye Res. 2010;90:429-36 pubmed publisher
    ..Expression of ChR2V was observed mainly in the retinal ganglion cells. These findings demonstrate that visual function can be restored in blind rats by transducing the ChR2V gene into retinal ganglion cells...
  57. Jones B, Watson N. Spatial memory performance in androgen insensitive male rats. Physiol Behav. 2005;85:135-41 pubmed
    ..These results support the suggestion that that AR mediated mechanisms contribute to the masculinization of spatial behaviours and hippocampal morphology, and this may be independent of estrogenic processes...
  58. Adeghate E, Rashed H, Rajbandari S, Singh J. Pattern of distribution of calcitonin gene-related Peptide in the dorsal root ganglion of animal models of diabetes mellitus. Ann N Y Acad Sci. 2006;1084:296-303 pubmed
    ..The reduced number of CGRP-positive neurons in the DRG of GK rats indicated that subjects with latent diabetes may already have dysfunctional CGRP metabolism and thus diabetic neuropathy...
  59. Durazzo A, Morris J, Breedlove S, Jordan C. Effects of the testicular feminization mutation (tfm) of the androgen receptor gene on BSTMPM volume and morphology in rats. Neurosci Lett. 2007;419:168-71 pubmed
    ..We found no sex difference in BSTMPM somal areas. These findings support the role of androgen receptors in the sexual differentiation of this nucleus...
  60. Petretto E, Sarwar R, Grieve I, Lu H, Kumaran M, Muckett P, et al. Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass. Nat Genet. 2008;40:546-52 pubmed publisher
    ..Taken together, these data implicate Ogn as a key regulator of LVM in rats, mice and humans, and suggest that Ogn modifies the hypertrophic response to extrinsic factors such as hypertension and aortic stenosis...
  61. Forssmann U, Stoetzer C, Stephan M, Kruschinski C, Skripuletz T, Schade J, et al. Inhibition of CD26/dipeptidyl peptidase IV enhances CCL11/eotaxin-mediated recruitment of eosinophils in vivo. J Immunol. 2008;181:1120-7 pubmed
    ..Furthermore, they illustrate that inhibitors of DPPIV have the potential to interfere with chemokine-mediated effects in vivo including but not limited to allergy...
  62. Ruth M, Proctor S, Field C. Feeding long-chain n-3 polyunsaturated fatty acids to obese leptin receptor-deficient JCR:LA- cp rats modifies immune function and lipid-raft fatty acid composition. Br J Nutr. 2009;101:1341-50 pubmed publisher
    ..Feeding FO lowered the ex vivo inflammatory response, without altering IL-2 production from ConA-stimulated splenocytes which may occur independent of leptin signalling...
  63. Hose S, Zigler J, Sinha D. A novel rat model to study the functions of macrophages during normal development and pathophysiology of the eye. Immunol Lett. 2005;96:299-302 pubmed
    ..Inflammation is known to have an enhanced influx of phagocytic cells. Our data suggests that subpopulations of macrophages perform distinct functions in inducing apoptosis and phagocytic activity during normal conditions and in disease...
  64. Knopfel M, Zhao L, Garrick M. Transport of divalent transition-metal ions is lost in small-intestinal tissue of b/b Belgrade rats. Biochemistry. 2005;44:3454-65 pubmed
    ..Immunofluorescent staining of thin sections of b/b and +/b proximal intestines confirmed that DMT1 localized similarly in mutant and control enterocytes and showed that DMT1 isoforms have distinct distributions within intestinal tissue...
  65. Pugliese G, Pricci F, Barsotti P, Iacobini C, Ricci C, Oddi G, et al. Development of diabetic nephropathy in the Milan normotensive strain, but not in the Milan hypertensive strain: possible permissive role of hemodynamics. Kidney Int. 2005;67:1440-52 pubmed
  66. Liu B, Zhang C, Qin F. Functional recovery from desensitization of vanilloid receptor TRPV1 requires resynthesis of phosphatidylinositol 4,5-bisphosphate. J Neurosci. 2005;25:4835-43 pubmed
  67. Hondo E, Kokubu K, Nagahisa A, Nakamuta N, Ozaki K, Sagara E, et al. Histological study of granulated metrial gland (GMG) cells in beige (DA-bg/bg) rats. J Reprod Dev. 2005;51:799-803 pubmed
    ..These results suggest that the activity of rat GMG cells and peripheral NK cells might be influenced by the beige gene, which is involved in reproductive performance...
  68. Ocaranza M, Palomera C, Roman M, Bargetto J, Lavandero S, Jalil J. Effect of hypertension on angiotensin-(1-7) levels in rats with different angiotensin-I converting enzyme polymorphism. Life Sci. 2006;78:1535-42 pubmed
    ..This inverse relation is due to genetically determined higher ACE activity. Besides, plasma levels of Ang-(1-7) increase in renovascular hypertension...
  69. Stemmer K, Ellinger Ziegelbauer H, Lotz K, Ahr H, Dietrich D. Establishment of a protocol for the gene expression analysis of laser microdissected rat kidney samples with affymetrix genechips. Toxicol Appl Pharmacol. 2006;217:134-42 pubmed
  70. McCampbell A, Walker C, Broaddus R, Cook J, Davies P. Developmental reprogramming of IGF signaling and susceptibility to endometrial hyperplasia in the rat. Lab Invest. 2008;88:615-26 pubmed publisher
  71. Hirano M, Rakwal R, Shibato J, Sawa H, Nagashima K, Ogawa Y, et al. Proteomics- and transcriptomics-based screening of differentially expressed proteins and genes in brain of Wig rat: a model for attention deficit hyperactivity disorder (ADHD) research. J Proteome Res. 2008;7:2471-89 pubmed publisher
  72. Pu M, Xu L, Zhang H. Visual response properties of retinal ganglion cells in the royal college of surgeons dystrophic rat. Invest Ophthalmol Vis Sci. 2006;47:3579-85 pubmed
    ..This method enabled the evaluation of the extent to which postreceptoral neuronal attributes in degenerating retinas mirror inferred declines in photoreceptor function...
  73. Yamada K, Hosokawa M, Fujimoto S, Nagashima K, Fukuda K, Fujiwara H, et al. The spontaneously diabetic Torii rat with gastroenteropathy. Diabetes Res Clin Pract. 2007;75:127-34 pubmed
    ..4+/-0.3%). Morphologically, the SDT rats exhibited longer villi and heavier weight of intestine compared to control SD rats. These results suggest that the SDT rat may be a useful animal model for studies of diabetic gastroenteropathy...
  74. Dalberg U, Markholst H, Hornum L. Both Gimap5 and the diabetogenic BBDP allele of Gimap5 induce apoptosis in T cells. Int Immunol. 2007;19:447-53 pubmed
    ..Finally, we detected the subcellular localization of Gimap5 to be at the endoplasmic reticulum and by quantitative PCR, we found that endogenous Gimap5 mRNA is up-regulated in activated T cells...
  75. Monosíková J, Herichova I, Mravec B, Kiss A, Zeman M. Effect of upregulated renin-angiotensin system on per2 and bmal1 gene expression in brain structures involved in blood pressure control in TGR(mREN-2)27 rats. Brain Res. 2007;1180:29-38 pubmed
    ..The area postrema seems to play a key role in the transmission of signals from the periphery to the CNS...
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    ..These results show that serotonergic 5-HT(1)-receptors are involved in the susceptibility of gripping-induced IEs in taiep rats. Similar results have been reported in the food-elicited cataplexy test in narcoleptic dogs...
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    ..We conclude that differential regulation of genes linked to extracellular matrix metabolism may be one of the first events leading to tubule enlargement and subsequent cyst formation in PKD...
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    ..The potential for dietary FO during pregnancy and lactation to positively modulate adult renal disease has significant implications for the 1 in 1000 individuals with congenital cystic kidney disease...
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    ..To determine the role of the terminal complement complex (TCC) in the development of experimental antigen-induced arthritis (AIA) and the therapeutic effects of human anti-C5 single-chain Fv (scFv)...
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    ..These results suggest that Mg deficiency causes acceleration of cataract development in SCR, probably due to a rise in the Ca2+ content in the lens...
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    ..MRP2 may therefore play a key role in the transport of moxifloxacin and its conjugates into bile in humans...
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    ..These results indicated that SDT fatty rat is a useful model to evaluate the functional or the morphological features in adipose tissue and develop a novel drug for antiobesity...
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    ..These results suggest that the OFA rats have impaired PRL release linked with an augmented dopaminergic tone which could be partially responsible for the lactational failure...
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    ..The LEA/SENDAI rats lacking DAO would be a useful tool for the investigations aimed at the elucidation of the relationships between this flavoenzyme and schizophrenia...
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    ..The authors explored donor cell behavior using human cortical neural progenitor cells (hNPC(ctx)) introduced into the subretinal space of normal rhesus macaques...
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    ..The present study provides new insights into the molecular basis for photoreceptor apoptosis in RCS rats and the future possibility of new pharmaceutical treatments for retinitis pigmentosa...