obese mice


Summary: Mutant mice exhibiting a marked obesity coupled with overeating, hyperglycemia, hyperinsulinemia, marked insulin resistance, and infertility when in a homozygous state. They may be inbred or hybrid.

Top Publications

  1. Cani P, Possemiers S, Van De Wiele T, Guiot Y, Everard A, Rottier O, et al. Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability. Gut. 2009;58:1091-103 pubmed publisher
  2. Dube M, Torto R, Kalra S. Increased leptin expression selectively in the hypothalamus suppresses inflammatory markers CRP and IL-6 in leptin-deficient diabetic obese mice. Peptides. 2008;29:593-8 pubmed publisher
  3. Smith A, Sheridan P, Tseng R, Sheridan J, Beck M. Selective impairment in dendritic cell function and altered antigen-specific CD8+ T-cell responses in diet-induced obese mice infected with influenza virus. Immunology. 2009;126:268-79 pubmed publisher
    ..We have previously reported that diet-induced obese mice are more susceptible to morbidity and mortality during influenza infection than lean mice...
  4. Dokmanovic Chouinard M, Chung W, Chevre J, Watson E, Yonan J, Wiegand B, et al. Positional cloning of "Lisch-Like", a candidate modifier of susceptibility to type 2 diabetes in mice. PLoS Genet. 2008;4:e1000137 pubmed publisher
    ..D congenic lines. The human ortholog, C1orf32, is in the middle of a 30-Mb region of Chr1q23-25 that has been repeatedly associated with type 2 diabetes. ..
  5. Xu A, Wang H, Hoo R, Sweeney G, Vanhoutte P, Wang Y, et al. Selective elevation of adiponectin production by the natural compounds derived from a medicinal herb alleviates insulin resistance and glucose intolerance in obese mice. Endocrinology. 2009;150:625-33 pubmed publisher
    ..Chronic administration of astragaloside II and isoastragaloside I in both dietary and genetic obese mice significantly elevated serum levels of total adiponectin and selectively increased the composition of its high ..
  6. Nakanishi N, Nakagawa Y, Tokushige N, Aoki N, Matsuzaka T, Ishii K, et al. The up-regulation of microRNA-335 is associated with lipid metabolism in liver and white adipose tissue of genetically obese mice. Biochem Biophys Res Commun. 2009;385:492-6 pubmed publisher
    ..The expressions of miR-335 in liver and white adipose tissue (WAT) were up-regulated in obese mice including ob/ob, db/db, and KKAy mice...
  7. Peterson S, Kim D, Li M, Positano V, Vanella L, Rodella L, et al. The L-4F mimetic peptide prevents insulin resistance through increased levels of HO-1, pAMPK, and pAKT in obese mice. J Lipid Res. 2009;50:1293-304 pubmed publisher
    ..The anti-obesity effects of L-4F are manifested by a decrease in visceral fat content with reciprocal increases in adiponectin, pAMPK, pAKT, and phosphorylation of insulin receptors with improved insulin sensitivity. ..
  8. Robert V, Bourgouin C, Depoix D, Thouvenot C, Lombard M, Grellier P. Malaria and obesity: obese mice are resistant to cerebral malaria. Malar J. 2008;7:81 pubmed publisher
    ..infection, this study applied a murine model, which uses the existence of genetically well characterized obese mice. The receptivity of obese homozygous ob/ob mice was compared to the receptivity of control heterozygous ob/+ ..
  9. van Eijk M, Aten J, Bijl N, Ottenhoff R, van Roomen C, Dubbelhuis P, et al. Reducing glycosphingolipid content in adipose tissue of obese mice restores insulin sensitivity, adipogenesis and reduces inflammation. PLoS ONE. 2009;4:e4723 pubmed publisher
    ..In conclusion, pharmacological lowering of glycosphingolipids by inhibition of glucosylceramide biosynthesis improves adipocyte function and as a consequence reduces inflammation in adipose tissue of obese animals. ..

More Information


  1. Allen D, Cleary A, Speaker K, Lindsay S, Uyenishi J, Reed J, et al. Myostatin, activin receptor IIb, and follistatin-like-3 gene expression are altered in adipose tissue and skeletal muscle of obese mice. Am J Physiol Endocrinol Metab. 2008;294:E918-27 pubmed publisher
  2. Tabata M, Kadomatsu T, Fukuhara S, Miyata K, Ito Y, Endo M, et al. Angiopoietin-like protein 2 promotes chronic adipose tissue inflammation and obesity-related systemic insulin resistance. Cell Metab. 2009;10:178-88 pubmed publisher
    ..Angptl2 deletion ameliorated adipose tissue inflammation and systemic insulin resistance in diet-induced obese mice. Conversely, Angptl2 overexpression in adipose tissue caused local inflammation and systemic insulin resistance ..
  3. Neyrinck A, Bindels L, De Backer F, Pachikian B, Cani P, Delzenne N. Dietary supplementation with chitosan derived from mushrooms changes adipocytokine profile in diet-induced obese mice, a phenomenon linked to its lipid-lowering action. Int Immunopharmacol. 2009;9:767-73 pubmed publisher
    ..to assess the relevance of this effect on the development of fat mass, and on glucose and lipid metabolism in obese mice. Mice were fed a HF diet or a HF diet supplemented with 5% fungal chitosan for ten weeks...
  4. Lee J, Padhye A, Sharma A, Song G, Miao J, Mo Y, et al. A pathway involving farnesoid X receptor and small heterodimer partner positively regulates hepatic sirtuin 1 levels via microRNA-34a inhibition. J Biol Chem. 2010;285:12604-11 pubmed publisher
    ..Remarkably, miR-34a levels were elevated, and SIRT1 protein levels were reduced in diet-induced obese mice, and FXR activation in these mice reversed the miR-34a and SIRT1 levels, indicating an intriguing link among FXR ..
  5. Membrez M, Blancher F, Jaquet M, Bibiloni R, Cani P, Burcelin R, et al. Gut microbiota modulation with norfloxacin and ampicillin enhances glucose tolerance in mice. FASEB J. 2008;22:2416-26 pubmed publisher
  6. Livingstone D, Grassick S, Currie G, Walker B, Andrew R. Dysregulation of glucocorticoid metabolism in murine obesity: comparable effects of leptin resistance and deficiency. J Endocrinol. 2009;201:211-8 pubmed publisher
    ..In liver, 5 beta-reductase activity and mRNA were increased and 11 beta-HSD1 decreased in obese mice, whereas 5 alpha-reductase 1 (5 alpha R1) mRNA was not altered...
  7. Hong J, Lee I. Effects of Artemisia capillaris ethyl acetate fraction on oxidative stress and antioxidant enzyme in high-fat diet induced obese mice. Chem Biol Interact. 2009;179:88-93 pubmed publisher
    ..capillaris ethyl acetate (ACE) fraction on oxidative stress and antioxidant enzyme in high-fat diet induced obese mice. C57BL/6J mice were randomly assigned to normal diet group and high-fat diet groups...
  8. Lee D, Kuo H, Chen C, Wei Y, Chou C, Hung J, et al. IKKbeta suppression of TSC1 function links the mTOR pathway with insulin resistance. Int J Mol Med. 2008;22:633-8 pubmed
    ..V-Lepob/J mice. Collectively, dysregulation of the TSC1/ TSC2/mTOR signaling pathway by IKKbeta is a common molecular switch for both cancer pathogenesis and diet- and obesity-induced insulin resistance...
  9. Li M, Kim D, Tsenovoy P, Peterson S, Rezzani R, Rodella L, et al. Treatment of obese diabetic mice with a heme oxygenase inducer reduces visceral and subcutaneous adiposity, increases adiponectin levels, and improves insulin sensitivity and glucose tolerance. Diabetes. 2008;57:1526-35 pubmed publisher
  10. Hennige A, Sartorius T, Lutz S, Tschritter O, Preissl H, Hopp S, et al. Insulin-mediated cortical activity in the slow frequency range is diminished in obese mice and promotes physical inactivity. Diabetologia. 2009;52:2416-2424 pubmed publisher
    ..There is evidence from mouse models and humans that alterations in insulin action in the brain are accompanied by an obese phenotype; however, the impact of insulin with regard to behavioural aspects such as locomotion is unknown...
  11. Arçari D, Bartchewsky W, dos Santos T, Oliveira K, Funck A, Pedrazzoli J, et al. Antiobesity effects of yerba maté extract (Ilex paraguariensis) in high-fat diet-induced obese mice. Obesity (Silver Spring). 2009;17:2127-33 pubmed publisher
    ..The F4/80 levels were determined by immunoblotting. We found that obese mice treated with yerba maté exhibited marked attenuation of weight gain, adiposity, a decrease in epididymal fat-..
  12. Wade T, Mathur A, Lu D, Swartz Basile D, Pitt H, Zyromski N. Adiponectin receptor-1 expression is decreased in the pancreas of obese mice. J Surg Res. 2009;154:78-84 pubmed publisher
    ..Adiponectin acts through two receptors, AdipoR1 and AdipoR2; no data are currently available regarding adiponection receptor expression in the obese murine pancreas...
  13. Berglund E, Li C, Bina H, Lynes S, Michael M, Shanafelt A, et al. Fibroblast growth factor 21 controls glycemia via regulation of hepatic glucose flux and insulin sensitivity. Endocrinology. 2009;150:4084-93 pubmed publisher
    ..Thus, these studies define mechanisms underlying anti-hyperglycemic actions of FGF21 and support its therapeutic potential...
  14. Bruno R, Dugan C, Smyth J, DiNatale D, Koo S. Green tea extract protects leptin-deficient, spontaneously obese mice from hepatic steatosis and injury. J Nutr. 2008;138:323-31 pubmed
    ..The body weights of obese mice and lean littermates fed diets containing GTE were 23-25% and 11-20% lower (P < 0...
  15. Feuerer M, Herrero L, Cipolletta D, Naaz A, Wong J, Nayer A, et al. Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat Med. 2009;15:930-9 pubmed publisher
    ..These observations suggest that harnessing the anti-inflammatory properties of T(reg) cells to inhibit elements of the metabolic syndrome may have therapeutic potential...
  16. Ussher J, Koves T, Jaswal J, Zhang L, Ilkayeva O, Dyck J, et al. Insulin-stimulated cardiac glucose oxidation is increased in high-fat diet-induced obese mice lacking malonyl CoA decarboxylase. Diabetes. 2009;58:1766-75 pubmed publisher
  17. Singer G, Stokes K, Terao S, Granger D. Sepsis-induced intestinal microvascular and inflammatory responses in obese mice. Shock. 2009;31:275-9 pubmed publisher
    ..Sepsis promotes more intense inflammatory and thrombogenic responses in the gut microcirculation of obese mice than in their lean counterparts...
  18. Yasuda Y, Shimizu M, Shirakami Y, Sakai H, Kubota M, Hata K, et al. Pitavastatin inhibits azoxymethane-induced colonic preneoplastic lesions in C57BL/KsJ-db/db obese mice. Cancer Sci. 2010;101:1701-7 pubmed publisher
    ..on the development of azoxymethane (AOM)-initiated colonic premalignant lesions in C57BL/KsJ-db/db (db/db) obese mice. Male db/db mice were administrated weekly subcutaneous injections of AOM (15 mg/kg body weight) for 4 weeks and ..
  19. Lopez M, Lage R, Saha A, Perez Tilve D, Vazquez M, Varela L, et al. Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin. Cell Metab. 2008;7:389-99 pubmed publisher
    ..Overall, our results indicate that modulation of hypothalamic fatty acid metabolism specifically in the VMH in response to ghrelin is a physiological mechanism that controls feeding...
  20. Peterson S, Drummond G, Kim D, Li M, Kruger A, Ikehara S, et al. L-4F treatment reduces adiposity, increases adiponectin levels, and improves insulin sensitivity in obese mice. J Lipid Res. 2008;49:1658-69 pubmed publisher
    ..enzymes and is vasoprotective in a rat model of diabetes, would ameliorate insulin resistance and diabetes in obese mice. L-4F (2 mg/kg/d) administered to ob/ob mice for 6 weeks limited weight gain without altering food intake, ..
  21. Shore S, Williams E, Zhu M. No effect of metformin on the innate airway hyperresponsiveness and increased responses to ozone observed in obese mice. J Appl Physiol (1985). 2008;105:1127-33 pubmed publisher
    ..Compared with water, treatment with metformin caused a significant decrease in fasting blood glucose in obese mice. Airway responsiveness was increased in db/db versus wild-type mice, but metformin did not affect responsiveness ..
  22. Grove K, Fried S, Greenberg A, Xiao X, Clegg D. A microarray analysis of sexual dimorphism of adipose tissues in high-fat-diet-induced obese mice. Int J Obes (Lond). 2010;34:989-1000 pubmed publisher
    ..was to systematically document depot- and sex-related differences in the accumulation of adipose tissue and gene expression, comparing differentially expressed genes in diet-induced obese mice with mice maintained on a chow diet.
  23. Yao Y, Li X, Zhao W, Zeng Y, Shen H, Xiang H, et al. Anti-obesity effect of an isoflavone fatty acid ester on obese mice induced by high fat diet and its potential mechanism. Lipids Health Dis. 2010;9:49 pubmed publisher
    ..In order to investigate the anti-obesity effect of compound 1a and its potential mechanism of influence in adipocyte differentiation, Obese male C57BL/6J mice induced by high-fat diet (HFD) and rat preadipocytes (3T3-L1 cell) were used...
  24. Hirata A, Maeda N, Hiuge A, Hibuse T, Fujita K, Okada T, et al. Blockade of mineralocorticoid receptor reverses adipocyte dysfunction and insulin resistance in obese mice. Cardiovasc Res. 2009;84:164-72 pubmed publisher
    ..However, the significance of MR in fat remains elusive. Here we investigated whether MR blockade attenuates obesity-related insulin resistance and improves adipocyte dysfunction...
  25. Lefebvre B, Benomar Y, Guédin A, Langlois A, Hennuyer N, Dumont J, et al. Proteasomal degradation of retinoid X receptor alpha reprograms transcriptional activity of PPARgamma in obese mice and humans. J Clin Invest. 2010;120:1454-68 pubmed publisher
    ..Here we report that the PPARgamma signaling pathway operates differently in the visceral WAT of lean and obese mice. PPARgamma in visceral, but not subcutaneous, WAT from obese mice displayed increased sensitivity to activation ..
  26. Guo Y, Wu G, Su X, Yang H, Zhang J. Antiobesity action of a daidzein derivative on male obese mice induced by a high-fat diet. Nutr Res. 2009;29:656-63 pubmed publisher
    ..this study, we investigate the effects of Dzd on body weight, adipose tissue, blood, and liver lipid levels in obese mice fed a high-fat diet...
  27. Turnbaugh P, Backhed F, Fulton L, Gordon J. Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome. Cell Host Microbe. 2008;3:213-23 pubmed publisher
    ..Our study illustrates how combining comparative metagenomics with gnotobiotic mouse models and specific dietary manipulations can disclose the niches of previously uncharacterized members of the gut microbiota...
  28. Sreejayan N, Dong F, Kandadi M, Yang X, Ren J. Chromium alleviates glucose intolerance, insulin resistance, and hepatic ER stress in obese mice. Obesity (Silver Spring). 2008;16:1331-7 pubmed publisher
    ..administration of a chromium complex of D-phenylalanine (Cr(D-phe)(3)) on glucose and insulin tolerance in obese mice. The study tested the hypothesis that Cr(D-phe)(3) suppresses endoplasmic reticulum (ER) stress and insulin ..
  29. Winer S, Chan Y, Paltser G, Truong D, Tsui H, Bahrami J, et al. Normalization of obesity-associated insulin resistance through immunotherapy. Nat Med. 2009;15:921-9 pubmed publisher
    ..The eventual failure of this control, with expanding adiposity and pathogenic VAT T cells, can successfully be reversed by immunotherapy...
  30. Lin Q, Gao Z, Alarcon R, Ye J, Yun Z. A role of miR-27 in the regulation of adipogenesis. FEBS J. 2009;276:2348-58 pubmed
    ..Importantly, expression of miR-27 was increased in fat tissue of obese mice and was regulated by hypoxia, an important extracellular stress associated with obesity...
  31. Fujisaka S, Usui I, Bukhari A, Ikutani M, Oya T, Kanatani Y, et al. Regulatory mechanisms for adipose tissue M1 and M2 macrophages in diet-induced obese mice. Diabetes. 2009;58:2574-82 pubmed publisher
    ..To characterize the phenotypic changes of adipose tissue macrophages (ATMs) under different conditions of insulin sensitivity...
  32. Kang J, Goto T, Han I, Kawada T, Kim Y, Yu R. Dietary capsaicin reduces obesity-induced insulin resistance and hepatic steatosis in obese mice fed a high-fat diet. Obesity (Silver Spring). 2010;18:780-7 pubmed publisher
    ..Male C57BL/6 obese mice fed a high-fat diet for 10 weeks received a supplement of 0...
  33. Wu K, Pan H, Yin H, Chen M, Lu S, Lin C. Change in P-glycoprotein and caveolin protein expression in brain striatum capillaries in New Zealand obese mice with type 2 diabetes. Life Sci. 2009;85:775-81 pubmed publisher
    ..To investigate the expression of P-gp and caveolins in brain striatum capillaries in inbred mice with type 2 diabetes...
  34. Krutzfeldt J, Stoffel M. Regulation of wingless-type MMTV integration site family (WNT) signalling in pancreatic islets from wild-type and obese mice. Diabetologia. 2010;53:123-7 pubmed publisher
    ..However, it is unknown whether this pathway is active in adult pancreatic islets in vivo, and whether it is regulated in obesity...
  35. Neyrinck A, De Backer F, Cani P, Bindels L, Stroobants A, Portetelle D, et al. Immunomodulatory properties of two wheat bran fractions - aleurone-enriched and crude fractions - in obese mice fed a high fat diet. Int Immunopharmacol. 2008;8:1423-32 pubmed publisher
    ..We propose that specific and early immunomodulatory properties of cereal products with prebiotic properties, may occur in obese mice independently of extensive gut fermentation.
  36. Kim M, Park B, Lee H, Park E, Hahm J, Lee J, et al. The anti-angiogenic herbal composition Ob-X inhibits adipose tissue growth in obese mice. Int J Obes (Lond). 2010;34:820-30 pubmed publisher
    ..As the composition of the herbal extract called Ob-X has been shown to have both anti-angiogenic and matrix metalloproteinase (MMP)-inhibiting activities, we hypothesized that growth of adipose tissue can be regulated by Ob-X...
  37. Izumiya Y, Hopkins T, Morris C, Sato K, Zeng L, Viereck J, et al. Fast/Glycolytic muscle fiber growth reduces fat mass and improves metabolic parameters in obese mice. Cell Metab. 2008;7:159-72 pubmed publisher
    ..Akt1 transgene induction in diet-induced obese mice led to reductions in body weight and fat mass, resolution of hepatic steatosis, and improved metabolic ..
  38. Kinney B, Qiao L, Levaugh J, Shao J. B56alpha/protein phosphatase 2A inhibits adipose lipolysis in high-fat diet-induced obese mice. Endocrinology. 2010;151:3624-32 pubmed publisher
    ..These results strongly suggest that elevated B56alpha/PP2A inhibits HSL and lipolysis in white adipose tissue of DIO mice...
  39. Peng Y, Rideout D, Rakita S, Sajan M, Farese R, You M, et al. Downregulation of adiponectin/AdipoR2 is associated with steatohepatitis in obese mice. J Gastrointest Surg. 2009;13:2043-9 pubmed publisher
    ..Adiponectin regulates fat storage, energy expenditure, and inflammation. We propose that high fat diet induces steatohepatitis, reduces serum adiponectin, and liver adiponectin receptors...
  40. McColl B, Rose N, Robson F, Rothwell N, Lawrence C. Increased brain microvascular MMP-9 and incidence of haemorrhagic transformation in obese mice after experimental stroke. J Cereb Blood Flow Metab. 2010;30:267-72 pubmed publisher
    ..incidence of haemorrhagic transformation and the volume of ischaemic brain damage were significantly greater in obese mice. Blood-brain barrier permeability and brain microvascular MMP-9 expression were also markedly increased in obese ..
  41. Fukuda M, Nakamura T, Kataoka K, Nako H, Tokutomi Y, Dong Y, et al. Potentiation by candesartan of protective effects of pioglitazone against type 2 diabetic cardiovascular and renal complications in obese mice. J Hypertens. 2010;28:340-52 pubmed publisher
    ..This study was undertaken to test the hypothesis that candesartan may enhance the protective effects of pioglitazone against type 2 diabetes...
  42. Burgess A, Li M, Vanella L, Kim D, Rezzani R, Rodella L, et al. Adipocyte heme oxygenase-1 induction attenuates metabolic syndrome in both male and female obese mice. Hypertension. 2010;56:1124-30 pubmed publisher
    ..inducer, cobalt protoporphyrin (CoPP), on regulation of adiposity and glucose levels in both female and male obese mice. Both lean and obese mice were administered CoPP intraperitoneally (3 mg/kg once per week) for 6 weeks...
  43. Gourcerol G, Wang L, Wang Y, Million M, Tache Y. Urocortins and cholecystokinin-8 act synergistically to increase satiation in lean but not obese mice: involvement of corticotropin-releasing factor receptor-2 pathway. Endocrinology. 2007;148:6115-23 pubmed
    ..Such synergy is lost in DIO mice, suggesting a resistance to the satiety signaling that may contribute to maintain obesity...
  44. Hur S, Whitcomb F, Rhee S, Park Y, Good D, Park Y. Effects of trans-10,cis-12 conjugated linoleic acid on body composition in genetically obese mice. J Med Food. 2009;12:56-63 pubmed publisher
    ..The effect of CLA to lower fat mass, increase lean body mass, and lower serum leptin and triglycerides in sedentary mice supports the possibility of using CLA to prevent or alleviate ailments associated with obesity...
  45. Oh H, Chung M, Kim S, Choi H, Ham S. Masou salmon (Oncorhynchus masou) ethanol extract decreases 3-hydroxy-3-methylglutaryl coenzyme A reductase expression in diet-induced obese mice. Nutr Res. 2009;29:123-9 pubmed publisher
    ..MSE) and to determine the molecular mechanism by which MSE exerts its effects in high-fat (HF) diet-induced obese mice. We hypothesize that the MSE may contain abundant n-3 fatty acids, so a diet containing MSE may also have ..
  46. Dong F, Ren J. Adiponectin improves cardiomyocyte contractile function in db/db diabetic obese mice. Obesity (Silver Spring). 2009;17:262-8 pubmed publisher
    ..Collectively, our data suggest that adiponectin improves cardiomyocyte dysfunction in db/db diabetic obese mice through a mechanism possibly related to c-Jun and IRS-1.
  47. Pan W, Hsuchou H, He Y, Sakharkar A, Cain C, Yu C, et al. Astrocyte leptin receptor (ObR) and leptin transport in adult-onset obese mice. Endocrinology. 2008;149:2798-806 pubmed publisher
  48. Wheatley K, Williams E, Smith N, Dillard A, Park E, Nunez N, et al. Low-carbohydrate diet versus caloric restriction: effects on weight loss, hormones, and colon tumor growth in obese mice. Nutr Cancer. 2008;60:61-8 pubmed publisher
    ..IGF-I levels were lower in the LC group (320.0 +/- 39.9 ng/ml) than the HF group, but tumor growth did not differ. These data suggest LC diets do not slow colon tumor growth in obese mice.
  49. Yu X, Murray S, Watts L, Booten S, Tokorcheck J, Monia B, et al. Reduction of JNK1 expression with antisense oligonucleotide improves adiposity in obese mice. Am J Physiol Endocrinol Metab. 2008;295:E436-45 pubmed publisher
    To investigate the role of JNK1 in metabolism, male ob/ob and diet-induced obese mice were treated with a JNK1-specific antisense oligonucleotide (ASO) or control ASO at 25 mg/kg or saline twice/wk for 6 and 7 wk, respectively...
  50. Pini M, Fantuzzi G. Enhanced production of IL-17A during zymosan-induced peritonitis in obese mice. J Leukoc Biol. 2010;87:51-8 pubmed publisher
    ..Peritoneal cells and adipose tissue obtained from ZY-injected obese mice expressed significantly higher levels of IL-17A mRNA compared with lean mice...
  51. Aasum E, Khalid A, Gudbrandsen O, How O, Berge R, Larsen T. Fenofibrate modulates cardiac and hepatic metabolism and increases ischemic tolerance in diet-induced obese mice. J Mol Cell Cardiol. 2008;44:201-9 pubmed
  52. Jang E, Kim H, Park C, Kang J. Increased expression of hepatic organic cation transporter 1 and hepatic distribution of metformin in high-fat diet-induced obese mice. Drug Metab Pharmacokinet. 2010;25:392-7 pubmed
    ..Since HF diet-induced obese mice exhibited elevation of plasma proinflammatory cytokines, leptin, and insulin levels, we evaluated the effect of ..
  53. Chen H, Dardik B, Qiu L, Ren X, Caplan S, Burkey B, et al. Cevoglitazar, a novel peroxisome proliferator-activated receptor-alpha/gamma dual agonist, potently reduces food intake and body weight in obese mice and cynomolgus monkeys. Endocrinology. 2010;151:3115-24 pubmed publisher
  54. Han K, Choi J, Lee J, Song J, Joe M, Jung M, et al. Therapeutic potential of peroxisome proliferators--activated receptor-alpha/gamma dual agonist with alleviation of endoplasmic reticulum stress for the treatment of diabetes. Diabetes. 2008;57:737-45 pubmed
    ..This study evaluated the function of macelignan, a natural compound isolated from Myristica fragrans, as a dual agonist for PPARalpha/gamma and investigated its antidiabetes effects in animal models...
  55. Cani P, Bibiloni R, Knauf C, Waget A, Neyrinck A, Delzenne N, et al. Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes. 2008;57:1470-81 pubmed publisher
    ..e., metabolic endotoxemia. Therefore, it remained to demonstrate whether changes in gut microbiota control the occurrence of metabolic diseases...
  56. López Parra M, Titos E, Horrillo R, Ferre N, González Périz A, Martínez Clemente M, et al. Regulatory effects of arachidonate 5-lipoxygenase on hepatic microsomal TG transfer protein activity and VLDL-triglyceride and apoB secretion in obese mice. J Lipid Res. 2008;49:2513-23 pubmed publisher
    ..Taken together, these findings identify a novel steatogenic role for 5-LO in the liver through mechanisms involving the regulation of hepatic MTP activity and VLDL-TG and apoB secretion...
  57. Kwon H, Won Y, Yoon W, Nam K, Kim D, Kim H. The role of osteopontin in d-galactosamine-induced liver injury in genetically obese mice. Toxicol Appl Pharmacol. 2010;242:344-51 pubmed publisher
    ..that osteopontin (OPN), an extracellular matrix and proinflammatory cytokine, has an important role in making obese mice more susceptible to inflammatory liver injury...
  58. Li H, Lelliott C, Håkansson P, Ploj K, Tuneld A, Verolin Johansson M, et al. Intestinal, adipose, and liver inflammation in diet-induced obese mice. Metabolism. 2008;57:1704-10 pubmed publisher
    ..Body weight of diet-induced obese mice was greatly increased, with evidence of systemic inflammation, insulin resistance, and liver steatosis...
  59. Ozcan L, Ergin A, Lu A, Chung J, Sarkar S, Nie D, et al. Endoplasmic reticulum stress plays a central role in development of leptin resistance. Cell Metab. 2009;9:35-51 pubmed publisher
    ..endoplasmic reticulum (ER) stress and activation of the unfolded protein response (UPR) in the hypothalamus of obese mice inhibits leptin receptor signaling...
  60. Poy M, Hausser J, Trajkovski M, Braun M, Collins S, Rorsman P, et al. miR-375 maintains normal pancreatic alpha- and beta-cell mass. Proc Natl Acad Sci U S A. 2009;106:5813-8 pubmed publisher
    ..In contrast, pancreatic islets of obese mice (ob/ob), a model of increased beta-cell mass, exhibit increased expression of miR-375...
  61. Jeong S, Yoon M. Fenofibrate inhibits adipocyte hypertrophy and insulin resistance by activating adipose PPARalpha in high fat diet-induced obese mice. Exp Mol Med. 2009;41:397-405 pubmed publisher
    ..Consistent with this hypothesis, fenofibrate decreased visceral fat mass and adipocyte size in high fat diet-fed obese mice, and concomitantly increased the expression of PPARalpha target genes involved in fatty acid beta-oxidation in ..
  62. Nishimura S, Manabe I, Nagasaki M, Eto K, Yamashita H, Ohsugi M, et al. CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat Med. 2009;15:914-20 pubmed publisher
    ..These results support the notion that CD8(+) T cells have an essential role in the initiation and propagation of adipose inflammation...
  63. Jourdan T, Djaouti L, Demizieux L, Gresti J, Verges B, Degrace P. CB1 antagonism exerts specific molecular effects on visceral and subcutaneous fat and reverses liver steatosis in diet-induced obese mice. Diabetes. 2010;59:926-34 pubmed publisher
    ..We examined the impact of CB1 antagonism on liver and adipose tissue lipid metabolism in a mouse model of diet-induced obesity...
  64. Wu Y, Brodt P, Sun H, Mejia W, Novosyadlyy R, Nunez N, et al. Insulin-like growth factor-I regulates the liver microenvironment in obese mice and promotes liver metastasis. Cancer Res. 2010;70:57-67 pubmed publisher
    ..the role of IGF-I in regulating the host microenvironment and colorectal carcinoma growth and metastasis in obese mice. Obese mice had a heightened inflammatory response in the liver, which was abolished in mice with chronic IGF-I ..
  65. Ueno N, Asakawa A, Inui A. Blunted metabolic response to fasting in obese mice. Endocrine. 2007;32:192-6 pubmed
    The aim of the study was to evaluate metabolic changes in response to fasting in normal and obese mice. C57BL6 and obese (diet-induced obesity (DIO) and ob/ob) mice were used in this study. They were fasted for 24 h and re-fed for 24 h...