biozzi mice


Summary: A strain of mice bred specifically as high or low antibody responders.

Top Publications

  1. Amor S, Smith P, Hart B, Baker D. Biozzi mice: of mice and human neurological diseases. J Neuroimmunol. 2005;165:1-10 pubmed
    ..In this paper we discuss the background of the Biozzi ABH mouse and review how studies with these mice have shed light on the pathogenic mechanisms operating in chronic neurological disease...
  2. Smith P, Morris Downes M, Heijmans N, Pryce G, Arter E, O Neill J, et al. Epitope spread is not critical for the relapse and progression of MOG 8-21 induced EAE in Biozzi ABH mice. J Neuroimmunol. 2005;164:76-84 pubmed
    ..These findings may have important implications for the efficacy of antigen-based immune therapies in autoimmune disorders...
  3. Pryce G, O Neill J, Croxford J, Amor S, Hankey D, East E, et al. Autoimmune tolerance eliminates relapses but fails to halt progression in a model of multiple sclerosis. J Neuroimmunol. 2005;165:41-52 pubmed
  4. Hall R, Hollis Moffatt J, Merriman M, Green R, Baker D, Merriman T. An autoimmune diabetes locus (Idd21) on mouse chromosome 18. Mamm Genome. 2003;14:335-9 pubmed
    ..The chromosome substitution strain (NOD.ABH-Chr18) had reduced diabetes incidence compared with NOD mice (P < 0.0001). We have named the Chr 18 diabetes locus Idd21...
  5. Craner M, Kataoka Y, Lo A, Black J, Baker D, Waxman S. Temporal course of upregulation of Na(v)1.8 in Purkinje neurons parallels the progression of clinical deficit in experimental allergic encephalomyelitis. J Neuropathol Exp Neurol. 2003;62:968-75 pubmed
    ..8 expression. These results provide evidence that the expression of sodium channel Na(v)1.8 contributes to the development of clinical deficits in an in vivo model of neuroinflammatory disease...
  6. Anderson J, Hampton D, Patani R, Pryce G, Crowther R, Reynolds R, et al. Abnormally phosphorylated tau is associated with neuronal and axonal loss in experimental autoimmune encephalomyelitis and multiple sclerosis. Brain. 2008;131:1736-48 pubmed publisher
    ..Together, these observations provide the first evidence implicating abnormal tau in the neurodegenerative phase of tissue injury in experimental and human demyelinating disease...
  7. You S, Chen C, Lee W, Wu C, Judkowski V, Pinilla C, et al. Detection and characterization of T cells specific for BDC2.5 T cell-stimulating peptides. J Immunol. 2003;170:4011-20 pubmed
    ..Therefore, we have generated Ag-specific tetramers that could detect a heterogeneous population of T cells, and a very small number of NOD mouse T cells may represent BDC2.5-like cells...
  8. Heijmans N, Smith P, Morris Downes M, Pryce G, Baker D, Donaldson A, et al. Encephalitogenic and tolerogenic potential of altered peptide ligands of MOG and PLP in Biozzi ABH mice. J Neuroimmunol. 2005;167:23-33 pubmed
  9. Jackson S, Lee J, Nikodemova M, Fabry Z, Duncan I. Quantification of myelin and axon pathology during relapsing progressive experimental autoimmune encephalomyelitis in the Biozzi ABH mouse. J Neuropathol Exp Neurol. 2009;68:616-25 pubmed publisher

More Information


  1. Bolton C, Scott G, Smith T, Flower R. The acute and chronic phases of chronic relapsing experimental autoimmune encephalomyelitis (CR EAE) are ameliorated by the peroxynitrite decomposition catalyst, 5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrinatoiron (III) chloride, (FeTPPS). Eur J Pharmacol. 2008;601:88-93 pubmed publisher
    ..Administration of FeTPPS to CR EAE-inoculated Biozzi mice commenced either therapeutically and immediately prior to the emergence of acute or relapse symptoms, or ..
  2. Huizinga R, Gerritsen W, Heijmans N, Amor S. Axonal loss and gray matter pathology as a direct result of autoimmunity to neurofilaments. Neurobiol Dis. 2008;32:461-70 pubmed publisher
    ..axonal damage and demyelination we have characterized the detailed neuropathology of NF-L-induced disease in Biozzi mice compared to classical experimental autoimmune encephalomyelitis (EAE) induced with myelin oligodendrocyte ..
  3. Hampton D, Anderson J, Pryce G, Irvine K, Giovannoni G, Fawcett J, et al. An experimental model of secondary progressive multiple sclerosis that shows regional variation in gliosis, remyelination, axonal and neuronal loss. J Neuroimmunol. 2008;201-202:200-11 pubmed publisher
    ..Together with the clinical pattern, our findings identify chronic EAE as an excellent model of secondary progressive multiple sclerosis...
  4. Huizinga R, Heijmans N, Schubert P, Gschmeissner S, t Hart B, Herrmann H, et al. Immunization with neurofilament light protein induces spastic paresis and axonal degeneration in Biozzi ABH mice. J Neuropathol Exp Neurol. 2007;66:295-304 pubmed
  5. Smith P, Heijmans N, Ouwerling B, Breij E, Evans N, van Noort J, et al. Native myelin oligodendrocyte glycoprotein promotes severe chronic neurological disease and demyelination in Biozzi ABH mice. Eur J Immunol. 2005;35:1311-9 pubmed
  6. de Lago E, Ligresti A, Ortar G, Morera E, Cabranes A, Pryce G, et al. In vivo pharmacological actions of two novel inhibitors of anandamide cellular uptake. Eur J Pharmacol. 2004;484:249-57 pubmed
  7. Hughes L, Smith P, Bonell S, Natt R, Wilson C, Rashid T, et al. Cross-reactivity between related sequences found in Acinetobacter sp., Pseudomonas aeruginosa, myelin basic protein and myelin oligodendrocyte glycoprotein in multiple sclerosis. J Neuroimmunol. 2003;144:105-15 pubmed
    ..Further work is required to evaluate the relevance of these cross-reactive antibodies to the neuropathology of MS...
  8. Verbeek R, van Dongen H, Wawrousek E, Amor S, van Noort J. Induction of EAE by T cells specific for alpha B-crystallin depends on prior viral infection in the CNS. Int Immunol. 2007;19:277-85 pubmed
    ..Our findings indicate that at least in mice, alpha B-crystallin-specific T cells can trigger EAE but only when prior viral infection has induced an inflammatory state in the CNS that helps recruit and activate T cells...
  9. Petzold A, Baker D, Pryce G, Keir G, Thompson E, Giovannoni G. Quantification of neurodegeneration by measurement of brain-specific proteins. J Neuroimmunol. 2003;138:45-8 pubmed
    ..These assays may facilitate the quantification of pathological features involved in neurodegeneration...