mice

Summary

Summary: The common name for the genus Mus.

Top Publications

  1. Riol Blanco L, Ordovas Montanes J, Perro M, Naval E, Thiriot A, Alvarez D, et al. Nociceptive sensory neurons drive interleukin-23-mediated psoriasiform skin inflammation. Nature. 2014;510:157-61 pubmed publisher
    ..We exposed the skin of mice to imiquimod, which induces IL-23-dependent psoriasis-like inflammation...
  2. Li Q, Chou D, Price T, Sundberg J, Uitto J. Genetic modulation of nephrocalcinosis in mouse models of ectopic mineralization: the Abcc6(tm1Jfk) and Enpp1(asj) mutant mice. Lab Invest. 2014;94:623-32 pubmed publisher
    ..diet in nephrocalcinosis using two established mouse models of ectopic mineralization, Abcc6(tm1Jfk) and Enpp1(asj) mice, which serve as models for pseudoxanthoma elasticum and generalized arterial calcification of infancy, two ..
  3. Donati G, Proserpio V, Lichtenberger B, Natsuga K, Sinclair R, Fujiwara H, et al. Epidermal Wnt/β-catenin signaling regulates adipocyte differentiation via secretion of adipogenic factors. Proc Natl Acad Sci U S A. 2014;111:E1501-9 pubmed publisher
  4. Seguin L, Kato S, Franovic A, Camargo M, Lesperance J, Elliott K, et al. An integrin β₃-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition. Nat Cell Biol. 2014;16:457-68 pubmed publisher
    ..This was observed in vitro and in mice bearing patient-derived tumour xenografts or in clinical specimens from lung cancer patients who had progressed on ..
  5. Gapp K, Jawaid A, Sarkies P, Bohacek J, Pelczar P, Prados J, et al. Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice. Nat Neurosci. 2014;17:667-9 pubmed publisher
    ..Injection of sperm RNAs from traumatized males into fertilized wild-type oocytes reproduced the behavioral and metabolic alterations in the resulting offspring. ..
  6. Bianchi E, Doe B, Goulding D, Wright G. Juno is the egg Izumo receptor and is essential for mammalian fertilization. Nature. 2014;508:483-7 pubmed publisher
    ..We show that the Izumo1-Juno interaction is conserved within several mammalian species, including humans. Female mice lacking Juno are infertile and Juno-deficient eggs do not fuse with normal sperm...
  7. Boroviak T, Loos R, Bertone P, Smith A, Nichols J. The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification. Nat Cell Biol. 2014;16:516-28 pubmed publisher
    ..These findings suggest that formation of the epiblast coincides with competence for ERK-independent self-renewal in vitro and consequent propagation as ESC lines. ..
  8. Bellavia M, Rappa F, Lo Bello M, Brecchia G, Tomasello G, Leone A, et al. Lactobacillus casei and bifidobacterium lactis supplementation reduces tissue damage of intestinal mucosa and liver after 2,4,6-trinitrobenzenesulfonic acid treatment in mice. J Biol Regul Homeost Agents. 2014;28:251-61 pubmed
    ..study was to investigate the intestinal and hepatic effects of PB supplementation in an experimental IBD model in mice induced by 2,4,6-trinitrobenzene sulfonic acid (TNBS)...
  9. Tong X, Ao Y, Faas G, Nwaobi S, Xu J, Haustein M, et al. Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington's disease model mice. Nat Neurosci. 2014;17:694-703 pubmed publisher
    ..K(+), ameliorated aspects of MSN dysfunction, prolonged survival and attenuated some motor phenotypes in R6/2 mice. These findings indicate that components of altered MSN excitability in HD may be caused by heretofore unknown ..

More Information

Publications72

  1. Ma Q, Zuo X, Yang F, Ubeda O, Gant D, Alaverdyan M, et al. Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging. J Neurosci. 2014;34:7124-36 pubmed publisher
    ..We report that old (19-20 months; OKO) but not middle-aged (8-9 months; MKO) tau knock-out mice develop Morris Water Maze (MWM) deficits and loss of hippocampal acetylated ?-tubulin and excitatory synaptic ..
  2. Zhang J, Lanuza G, Britz O, Wang Z, Siembab V, Zhang Y, et al. V1 and v2b interneurons secure the alternating flexor-extensor motor activity mice require for limbed locomotion. Neuron. 2014;82:138-50 pubmed publisher
    ..b>Mice lacking V1 and V2b inhibition are unable to articulate their limb joints and display marked deficits in limb-driven ..
  3. Liu H, Qi X, Cao S, Li P. Protective effect of flavonoid extract from Chinese bayberry (Myrica rubra Sieb. et Zucc.) fruit on alcoholic liver oxidative injury in mice. J Nat Med. 2014;68:521-9 pubmed publisher
    ..et Zucc.) flavonoid extract (CBFE) on chronic alcohol-induced liver oxidative injury in mice, experimental mice were pretreated with different doses of CBFE (50-200 mg/kg) for 4 weeks by gavage feeding...
  4. Barozzi I, Simonatto M, Bonifacio S, Yang L, Rohs R, Ghisletti S, et al. Coregulation of transcription factor binding and nucleosome occupancy through DNA features of mammalian enhancers. Mol Cell. 2014;54:844-857 pubmed publisher
    ..1 binding and nucleosome occupancy genome-wide. These data reveal a basic organizational principle of mammalian cis-regulatory elements whereby TF recruitment and nucleosome deposition are controlled by overlapping DNA sequence features. ..
  5. Deng R, Khattar M, Xie A, Schroder P, He X, Chen W, et al. Anti-TCR mAb induces peripheral tolerance to alloantigens and delays islet allograft rejection in autoimmune diabetic NOD mice. Transplantation. 2014;97:1216-24 pubmed publisher
    ..clone H57-597), resulting in long-term survival of BALB/c islet allografts in streptozotocin-induced diabetic B6 mice. Moreover, transient anti-TCR treatment permanently prevented BALB/c skin allograft rejection on Rag1 B6 recipients ..
  6. Sadagurski M, Landeryou T, Blandino Rosano M, Cady G, Elghazi L, Meister D, et al. Long-lived crowded-litter mice exhibit lasting effects on insulin sensitivity and energy homeostasis. Am J Physiol Endocrinol Metab. 2014;306:E1305-14 pubmed publisher
    ..of pups in the crowded-litter (CL) model] leads to extension of mean and maximal lifespan in genetically normal mice. In this study, we aimed to characterize the impact of early-life nutrient intervention on glucose metabolism and ..
  7. Bosen F, Schütz M, Beinhauer A, Strenzke N, Franz T, Willecke K. The Clouston syndrome mutation connexin30 A88V leads to hyperproliferation of sebaceous glands and hearing impairments in mice. FEBS Lett. 2014;588:1795-801 pubmed publisher
    ..Homozygous Cx30A88V mice reveal hyperproliferative and enlarged sebaceous glands as well as a mild palmoplantar hyperkeratosis...
  8. Riddell J, Gazit R, Garrison B, Guo G, Saadatpour A, Mandal P, et al. Reprogramming committed murine blood cells to induced hematopoietic stem cells with defined factors. Cell. 2014;157:549-64 pubmed publisher
    ..Our results raise the prospect that blood cell reprogramming may be a strategy for derivation of transplantable stem cells for clinical application...
  9. Sandler V, Lis R, Liu Y, Kedem A, James D, Elemento O, et al. Reprogramming human endothelial cells to haematopoietic cells requires vascular induction. Nature. 2014;511:312-8 pubmed publisher
    ..into human MPPs (rEC-hMPPs) acquire colony-forming-cell potential and durably engraft into immune-deficient mice after primary and secondary transplantation, producing long-term rEC-hMPP-derived myeloid (granulocytic/monocytic, ..
  10. Tong Q, He S, Xie F, Mochizuki K, Liu Y, Mochizuki I, et al. Ezh2 regulates transcriptional and posttranslational expression of T-bet and promotes Th1 cell responses mediating aplastic anemia in mice. J Immunol. 2014;192:5012-22 pubmed publisher
    ..reduced the production of BM-destructive Th1 cells in vivo, decreased BM-infiltrating Th1 cells, and rescued mice from BM failure...
  11. Qiu Z, Dubin A, Mathur J, Tu B, Reddy K, Miraglia L, et al. SWELL1, a plasma membrane protein, is an essential component of volume-regulated anion channel. Cell. 2014;157:447-458 pubmed publisher
    ..These findings enable further molecular characterization of the VRAC channel complex and genetic studies for understanding the function of VRAC in normal physiology and disease...
  12. Rickard J, O Donnell J, Evans J, Lalaoui N, Poh A, Rogers T, et al. RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis. Cell. 2014;157:1175-88 pubmed publisher
    ..We show that C57BL/6 Ripk1(-/-) mice die at birth of systemic inflammation that was not transferable by the hematopoietic compartment...
  13. Williams J, Patel J, Daniels B, Klein R. Targeting CXCR7/ACKR3 as a therapeutic strategy to promote remyelination in the adult central nervous system. J Exp Med. 2014;211:791-9 pubmed publisher
    ..These findings identify a role for CXCR7 in OPC maturation during remyelination and are the first to use a small molecule to therapeutically enhance myelin repair in the demyelinated adult CNS. ..
  14. Broquet A, Roquilly A, Jacqueline C, Potel G, Caillon J, Asehnoune K. Depletion of natural killer cells increases mice susceptibility in a Pseudomonas aeruginosa pneumonia model. Crit Care Med. 2014;42:e441-50 pubmed publisher
    ..In this setting, the role of natural killer cells remains controversial. We assessed the role of systemic natural killer cells in a Pseudomonas aeruginosa mouse pneumonia model...
  15. Li D, Sakuma R, Vakili N, Mo R, Puviindran V, Deimling S, et al. Formation of proximal and anterior limb skeleton requires early function of Irx3 and Irx5 and is negatively regulated by Shh signaling. Dev Cell. 2014;29:233-40 pubmed publisher
    ..However, these skeletal elements can be restored in Irx3/5 null mice when Shh signaling is diminished, indicating that Shh negatively regulates their formation after initiation...
  16. Malki S, van der Heijden G, O Donnell K, Martin S, Bortvin A. A role for retrotransposon LINE-1 in fetal oocyte attrition in mice. Dev Cell. 2014;29:521-533 pubmed publisher
    ..retrotransposons LINE-1 (L1), activated during epigenetic reprogramming of the embryonic germline, in FOA in mice. We show that wild-type fetal oocytes possess differential nuclear levels of L1ORF1p, an L1-encoded protein ..
  17. Chivukula R, Shi G, Acharya A, Mills E, Zeitels L, Anandam J, et al. An essential mesenchymal function for miR-143/145 in intestinal epithelial regeneration. Cell. 2014;157:1104-16 pubmed publisher
    ..We generated mice with deletion of miR-143/145 to investigate the functions of these miRNAs in intestinal physiology and disease in ..
  18. Clopath C, Badura A, De Zeeuw C, Brunel N. A cerebellar learning model of vestibulo-ocular reflex adaptation in wild-type and mutant mice. J Neurosci. 2014;34:7203-15 pubmed publisher
    ..a simple form of motor learning for which a large body of experimental data is available in wild-type and mutant mice, in which the excitability of granule cells or inhibition of Purkinje cells was affected in a cell-specific fashion...
  19. Mathews S, Xu M, Wang H, Bertola A, Gao B. Animals models of gastrointestinal and liver diseases. Animal models of alcohol-induced liver disease: pathophysiology, translational relevance, and challenges. Am J Physiol Gastrointest Liver Physiol. 2014;306:G819-23 pubmed publisher
    ..Recently, we developed a chronic plus binge alcohol feeding model in mice that is similar to the drinking patterns of many alcoholic hepatitis patients: a history of chronic drinking and ..
  20. Park J, Kwok S, Lim M, Kim E, Ryu J, Kim S, et al. STA-21, a promising STAT-3 inhibitor that reciprocally regulates Th17 and Treg cells, inhibits osteoclastogenesis in mice and humans and alleviates autoimmune inflammation in an experimental model of rheumatoid arthritis. Arthritis Rheumatol. 2014;66:918-29 pubmed publisher
    ..and progression of inflammatory arthritis and to determine the possible mechanisms by which STA-21 has antiarthritic effects in interleukin-1 receptor antagonist-knockout (IL-1Ra-KO) mice, an animal model of rheumatoid arthritis (RA).
  21. Saito T, Matsuba Y, Mihira N, Takano J, Nilsson P, Itohara S, et al. Single App knock-in mouse models of Alzheimer's disease. Nat Neurosci. 2014;17:661-3 pubmed publisher
    Experimental studies of Alzheimer's disease have largely depended on transgenic mice overexpressing amyloid precursor protein (APP)...
  22. Dillon C, Weinlich R, Rodriguez D, Cripps J, Quarato G, Gurung P, et al. RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3. Cell. 2014;157:1189-202 pubmed publisher
    ..The role of RIPK3 in promoting lethality in ripk1(-/-) mice suggests that RIPK3 activation is inhibited by RIPK1 postbirth...
  23. Nguyen L, Ma D, Shui G, Wong P, Cazenave Gassiot A, Zhang X, et al. Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid. Nature. 2014;509:503-6 pubmed publisher
    ..Lipidomic analysis indicates that Mfsd2a-deficient (Mfsd2a-knockout) mice show markedly reduced levels of DHA in brain accompanied by neuronal cell loss in hippocampus and cerebellum, as ..
  24. Tsiganov E, Verbina E, Radaeva T, Sosunov V, Kosmiadi G, Nikitina I, et al. Gr-1dimCD11b+ immature myeloid-derived suppressor cells but not neutrophils are markers of lethal tuberculosis infection in mice. J Immunol. 2014;192:4718-27 pubmed publisher
    ..In this study, we show that in mice, TB progression is associated with the accumulation of cells that express neutrophilic markers Gr-1 and Ly-6G but ..
  25. Liu Y, McDowell C, Zhang Z, Tebow H, Wordinger R, Clark A. Monitoring retinal morphologic and functional changes in mice following optic nerve crush. Invest Ophthalmol Vis Sci. 2014;55:3766-74 pubmed publisher
    We characterized the morphologic and functional changes in optic nerve crushed mice and evaluated electroretinogram (ERG) responses as tools to monitor retinal ganglion cell (RGC) dysfunction.
  26. Newman R, Dee M, Malek T, Podack E, Levy R. Heat shock protein vaccination and directed IL-2 therapy amplify tumor immunity rapidly following bone marrow transplantation in mice. Blood. 2014;123:3045-55 pubmed publisher
    ..2 weeks of T cell-replete syngeneic HSCT led to cross-presentation and increased survival of lymphoma-bearing mice. To enhance vaccine efficacy, interleukin (IL)-2 was directed to predominantly memory phenotype CD8(+) T ..
  27. Cunningham J, Moreno M, Lodi A, Ronen S, Ruggero D. Protein and nucleotide biosynthesis are coupled by a single rate-limiting enzyme, PRPS2, to drive cancer. Cell. 2014;157:1088-103 pubmed publisher
    ..Together, these studies identify a translationally anchored anabolic circuit critical for cancer cell survival and an unexpected vulnerability for "undruggable" oncogenes, such as Myc. PAPERFLICK:..
  28. Preußner M, Wilhelmi I, Schultz A, Finkernagel F, Michel M, Moroy T, et al. Rhythmic U2af26 alternative splicing controls PERIOD1 stability and the circadian clock in mice. Mol Cell. 2014;54:651-62 pubmed publisher
    ..This new U2AF26 variant destabilizes PERIOD1 protein, and U2AF26-deficient mice show nearly arrhythmic PERIOD1 protein levels and broad defects in circadian mRNA expression in peripheral clocks...
  29. Schrode N, Saiz N, Di Talia S, Hadjantonakis A. GATA6 levels modulate primitive endoderm cell fate choice and timing in the mouse blastocyst. Dev Cell. 2014;29:454-67 pubmed publisher
    ..This study provides a framework for quantitative analyses of mammalian embryos and establishes GATA6 as a nodal point in the gene regulatory network driving ICM lineage specification. ..
  30. Ferrer C, Lynch T, Sodi V, Falcone J, Schwab L, Peacock D, et al. O-GlcNAcylation regulates cancer metabolism and survival stress signaling via regulation of the HIF-1 pathway. Mol Cell. 2014;54:820-31 pubmed publisher
    ..Thus, O-GlcNAcylation regulates cancer cell metabolic reprograming and survival stress signaling via regulation of HIF-1?...
  31. Beaty B, Wang Y, Bravo Cordero J, Sharma V, Miskolci V, Hodgson L, et al. Talin regulates moesin-NHE-1 recruitment to invadopodia and promotes mammary tumor metastasis. J Cell Biol. 2014;205:737-51 pubmed publisher
    ..Thus, our findings provide a novel understanding of how intracellular pH is regulated and a molecular mechanism by which talin enhances tumor cell invasion and metastasis...
  32. Chin R, Fu X, Pai M, Vergnes L, Hwang H, Deng G, et al. The metabolite ?-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR. Nature. 2014;510:397-401 pubmed publisher
  33. McKenney R, Huynh W, Tanenbaum M, Bhabha G, Vale R. Activation of cytoplasmic dynein motility by dynactin-cargo adapter complexes. Science. 2014;345:337-41 pubmed publisher
    ..Thus, we propose that dynein is largely inactive in the cytoplasm and that a variety of adapter proteins activate processive motility by linking dynactin to dynein only when the motor is bound to its proper cargo. ..
  34. Bagavant H, Nandula S, Kaplonek P, Rybakowska P, Deshmukh U. Alum, an aluminum-based adjuvant, induces Sjögren's syndrome-like disorder in mice. Clin Exp Rheumatol. 2014;32:251-5 pubmed
    ..This study investigates the role of alum, an aluminum-based adjuvant in the induction of Sjögren's syndrome-like disorder in mice.
  35. Elmore M, Najafi A, Koike M, Dagher N, Spangenberg E, Rice R, et al. Colony-stimulating factor 1 receptor signaling is necessary for microglia viability, unmasking a microglia progenitor cell in the adult brain. Neuron. 2014;82:380-97 pubmed publisher
    ..To this end, we tested the effects of selective CSF1R inhibitors on microglia in adult mice. Surprisingly, extensive treatment results in elimination of ?99% of all microglia brain-wide, showing that ..
  36. Mohamed J, Hajira A, Pardo P, Boriek A. MicroRNA-149 inhibits PARP-2 and promotes mitochondrial biogenesis via SIRT-1/PGC-1? network in skeletal muscle. Diabetes. 2014;63:1546-59 pubmed publisher
    ..In addition, skeletal muscles from HFD-fed obese mice exhibit low levels of miR-149 and high levels of PARP-2, and they show reduced mitochondrial function and ..
  37. Durruthy Durruthy R, Gottlieb A, Hartman B, Waldhaus J, Laske R, Altman R, et al. Reconstruction of the mouse otocyst and early neuroblast lineage at single-cell resolution. Cell. 2014;157:964-78 pubmed publisher
    ..Our bioinformatic modeling revealed spatial dynamics of different signaling pathways active during early neuroblast development and prosensory domain specification...
  38. Goulding J, Abboud G, Tahiliani V, Desai P, Hutchinson T, Salek Ardakani S. CD8 T cells use IFN-? to protect against the lethal effects of a respiratory poxvirus infection. J Immunol. 2014;192:5415-25 pubmed publisher
    ..Using a model of respiratory vaccinia virus infection in mice, we could specifically determine the relative contribution of perforin, TRAIL, and IFN-?-mediated pathways in ..
  39. Huber K, Salah E, Radic B, Gridling M, Elkins J, Stukalov A, et al. Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy. Nature. 2014;508:222-7 pubmed publisher
    ..Our results propose (S)-crizotinib as an attractive chemical entity for further pre-clinical evaluation, and small-molecule inhibitors of MTH1 in general as a promising novel class of anticancer agents. ..
  40. Florea V, Cohn J. The autonomic nervous system and heart failure. Circ Res. 2014;114:1815-26 pubmed publisher
  41. Qiang L, Zhao B, Ming M, Wang N, He T, Hwang S, et al. Regulation of cell proliferation and migration by p62 through stabilization of Twist1. Proc Natl Acad Sci U S A. 2014;111:9241-6 pubmed publisher
    ..p62 binds to Twist1 and inhibits degradation of Twist1. In mice, p62 up-regulation promotes tumor cell growth and metastasis in a Twist1-dependent manner...
  42. Treutlein B, Brownfield D, Wu A, Neff N, Mantalas G, Espinoza F, et al. Reconstructing lineage hierarchies of the distal lung epithelium using single-cell RNA-seq. Nature. 2014;509:371-5 pubmed publisher
    ..This single-cell genomics approach is applicable to any developing or mature tissue to robustly delineate molecularly distinct cell types, define progenitors and lineage hierarchies, and identify lineage-specific regulatory factors. ..
  43. Lívero F, Stolf A, Dreifuss A, Bastos Pereira A, Chicorski R, de Oliveira L, et al. The FXR agonist 6ECDCA reduces hepatic steatosis and oxidative stress induced by ethanol and low-protein diet in mice. Chem Biol Interact. 2014;217:19-27 pubmed publisher
  44. Weissmueller S, Manchado E, Saborowski M, Morris J, Wagenblast E, Davis C, et al. Mutant p53 drives pancreatic cancer metastasis through cell-autonomous PDGF receptor ? signaling. Cell. 2014;157:382-394 pubmed publisher
    ..Finally, high PDGFRb expression correlates with poor disease-free survival in pancreatic, colon, and ovarian cancer patients, implicating PDGFRb as a prognostic marker and possible target for attenuating metastasis in p53 mutant tumors...
  45. Toubai T, Hou G, Mathewson N, Liu C, Wang Y, Oravecz Wilson K, et al. Siglec-G-CD24 axis controls the severity of graft-versus-host disease in mice. Blood. 2014;123:3512-23 pubmed publisher
    ..Mechanistic studies with various relevant Siglec-G and CD24 knockout mice and chimeric animals, along with rescue experiments with novel CD24 fusion protein demonstrate that enhancing the ..
  46. Zhao X, Guo F, Liu F, Cuconati A, Chang J, Block T, et al. Interferon induction of IFITM proteins promotes infection by human coronavirus OC43. Proc Natl Acad Sci U S A. 2014;111:6756-61 pubmed publisher
    ..The observed enhancement of HCoV-OC43 infection by IFNs may underlie the propensity of the virus to invade the lower respiratory tract under inflammatory conditions. ..
  47. Dunn S, Martello G, Yordanov B, Emmott S, Smith A. Defining an essential transcription factor program for naïve pluripotency. Science. 2014;344:1156-1160 pubmed publisher
    ..We propose that propagation of ES cell identity is not determined by a vast interactome but rather can be explained by a relatively simple process of molecular computation. ..
  48. Yuan J, Yang F, Wang F, Ma J, Guo Y, Tao Q, et al. A long noncoding RNA activated by TGF-? promotes the invasion-metastasis cascade in hepatocellular carcinoma. Cancer Cell. 2014;25:666-81 pubmed publisher
    ..Thus, these findings suggest that lncRNA-ATB, a mediator of TGF-? signaling, could predispose HCC patients to metastases and may serve as a potential target for antimetastatic therapies. ..
  49. Berger S, Kasparcova V, Hoffman S, Swift B, Dare L, Schaeffer M, et al. Cutting Edge: RIP1 kinase activity is dispensable for normal development but is a key regulator of inflammation in SHARPIN-deficient mice. J Immunol. 2014;192:5476-80 pubmed publisher
    ..during development and TNF-dependent inflammation has been hampered by the perinatal lethality of RIP1-deficient mice. In this study, we generated RIP1 kinase-dead (Ripk1(K45A)) mice and showed they are viable and healthy, indicating ..
  50. Paszek M, DuFort C, Rossier O, Bainer R, Mouw J, Godula K, et al. The cancer glycocalyx mechanically primes integrin-mediated growth and survival. Nature. 2014;511:319-25 pubmed publisher
    ..Thus, a bulky glycocalyx is a feature of tumour cells that could foster metastasis by mechanically enhancing cell-surface receptor function. ..
  51. Zhao R, Xu X, Xu F, Zhang W, Zhang W, Liu L, et al. Metformin protects against seizures, learning and memory impairments and oxidative damage induced by pentylenetetrazole-induced kindling in mice. Biochem Biophys Res Commun. 2014;448:414-7 pubmed publisher
    ..Male C57BL/6 mice were administered with subconvulsive dose of pentylenetetrazole (37 mg/kg, i.p.) every other day for 14 injections...
  52. Denzler R, Agarwal V, Stefano J, Bartel D, Stoffel M. Assessing the ceRNA hypothesis with quantitative measurements of miRNA and target abundance. Mol Cell. 2014;54:766-76 pubmed publisher
    ..Thus, modulation of miRNA target abundance is unlikely to cause significant effects on gene expression and metabolism through a ceRNA effect...
  53. Muñoz Espín D, Serrano M. Cellular senescence: from physiology to pathology. Nat Rev Mol Cell Biol. 2014;15:482-96 pubmed publisher
    ..Conversely, antisenescent therapies may help to eliminate accumulated senescent cells and to recover tissue function. ..
  54. Sanders D, Kaufman S, DeVos S, Sharma A, Mirbaha H, Li A, et al. Distinct tau prion strains propagate in cells and mice and define different tauopathies. Neuron. 2014;82:1271-88 pubmed publisher
    ..induce distinct pathologies in vivo as determined by successive inoculations into three generations of transgenic mice. Immunopurified tau from these mice recreates the original strains in culture...
  55. Deshmukh H, Liu Y, Menkiti O, Mei J, Dai N, O Leary C, et al. The microbiota regulates neutrophil homeostasis and host resistance to Escherichia coli K1 sepsis in neonatal mice. Nat Med. 2014;20:524-30 pubmed publisher
    ..These data support a role for the intestinal microbiota in regulation of granulocytosis, neutrophil homeostasis and host resistance to sepsis in neonates. ..
  56. Tsiantoulas D, Diehl C, Witztum J, Binder C. B cells and humoral immunity in atherosclerosis. Circ Res. 2014;114:1743-56 pubmed publisher
    ..Moreover, we will highlight potential therapeutic approaches focusing on B-cell depletion that could be used to translate experimental evidence to human disease...
  57. Bogen I, Boix F, Nerem E, Mørland J, Andersen J. A monoclonal antibody specific for 6-monoacetylmorphine reduces acute heroin effects in mice. J Pharmacol Exp Ther. 2014;349:568-76 pubmed publisher
    ..b>Mice pretreated with the mAb toward 6-MAM displayed a reduction in heroin-induced locomotor activity that corresponded ..
  58. Velazquez K, Enos R, Narsale A, Puppa M, Davis J, Murphy E, et al. Quercetin supplementation attenuates the progression of cancer cachexia in ApcMin/+ mice. J Nutr. 2014;144:868-75 pubmed publisher
    ..At 15 wk of age, C57BL/6 and male Apc(Min/+) mice were supplemented with 25 mg/kg of quercetin or vehicle solution mix of Tang juice and water (V) daily for 3 wk...
  59. Shirakawa J, Okuyama T, Yoshida E, Shimizu M, Horigome Y, Tuno T, et al. Effects of the antitumor drug OSI-906, a dual inhibitor of IGF-1 receptor and insulin receptor, on the glycemic control, ?-cell functions, and ?-cell proliferation in male mice. Endocrinology. 2014;155:2102-11 pubmed publisher
    ..the impact of OSI-906 on glycemic control, insulin secretion, ?-cell mass, and ?-cell proliferation in male mice. Oral administration of OSI-906 worsened glucose tolerance in a dose-dependent manner in the wild-type mice...
  60. Murphy A, Macdonald L, Stevens S, Karow M, Dore A, Pobursky K, et al. Mice with megabase humanization of their immunoglobulin genes generate antibodies as efficiently as normal mice. Proc Natl Acad Sci U S A. 2014;111:5153-8 pubmed publisher
    b>Mice genetically engineered to be humanized for their Ig genes allow for human antibody responses within a mouse background (HumAb mice), providing a valuable platform for the generation of fully human therapeutic antibodies...
  61. Liu Z, Ciocea A, Devireddy L. Endogenous siderophore 2,5-dihydroxybenzoic acid deficiency promotes anemia and splenic iron overload in mice. Mol Cell Biol. 2014;34:2533-46 pubmed publisher
    ..bdh2 null mice developed microcytic anemia and tissue iron overload, especially in the spleen...
  62. Qiu Y, Shil P, Zhu P, Yang H, Verma A, Lei B, et al. Angiotensin-converting enzyme 2 (ACE2) activator diminazene aceturate ameliorates endotoxin-induced uveitis in mice. Invest Ophthalmol Vis Sci. 2014;55:3809-18 pubmed publisher
    ..The purpose of this study was to investigate the effect of endogenous ACE2 activation in preventing endotoxin-induced uveitis (EIU) in mice.
  63. Dawlaty M, Breiling A, Le T, Barrasa M, Raddatz G, Gao Q, et al. Loss of Tet enzymes compromises proper differentiation of embryonic stem cells. Dev Cell. 2014;29:102-11 pubmed publisher
    ..These findings suggest a requirement for Tet- and 5hmC-mediated DNA demethylation in proper regulation of gene expression during ESC differentiation and development...