chinchilla

Summary

Summary: A genus of the family Chinchillidae which consists of three species: C. brevicaudata, C. lanigera, and C. villidera. They are used extensively in biomedical research.

Top Publications

  1. Sabharwal V, Ram S, Figueira M, Park I, Pelton S. Role of complement in host defense against pneumococcal otitis media. Infect Immun. 2009;77:1121-7 pubmed publisher
    ..Thus, limiting C3 deposition on the surface of S. pneumoniae correlates with increased incidence of EOM following NP colonization and barotrauma in the animal model...
  2. Shaffer T, Balder R, Buskirk S, Hogan R, Lafontaine E. Use of the Chinchilla model to evaluate the vaccinogenic potential of the Moraxella catarrhalis filamentous hemagglutinin-like proteins MhaB1 and MhaB2. PLoS ONE. 2013;8:e67881 pubmed publisher
    ..To address this, we intranasally infected chinchilla with M. catarrhalis to investigate colonization and examine the efficacy of a protein-based vaccine...
  3. Kerschner J, Khampang P, Samuels T. Extending the chinchilla middle ear epithelial model for mucin gene investigation. Int J Pediatr Otorhinolaryngol. 2010;74:980-5 pubmed publisher
    To investigate the expression of recently identified human mucin genes in an in vivo model of the chinchilla middle ear epithelium (CMEE).
  4. Kyd J, Cripps A, Novotny L, Bakaletz L. Efficacy of the 26-kilodalton outer membrane protein and two P5 fimbrin-derived immunogens to induce clearance of nontypeable Haemophilus influenzae from the rat middle ear and lungs as well as from the chinchilla middle ear and nasopharynx. Infect Immun. 2003;71:4691-9 pubmed
    ..Similarly, the chinchilla model of middle ear and nasopharyngeal clearance has been used to show that two P5 fimbrin adhesin-derived ..
  5. Laufer A, Thomas J, Figueira M, Gent J, Pelton S, Pettigrew M. Capacity of serotype 19A and 15B/C Streptococcus pneumoniae isolates for experimental otitis media: Implications for the conjugate vaccine. Vaccine. 2010;28:2450-7 pubmed publisher
    ..sequence type (ST199) but different serotypes (15B/C, 19A) for growth in vitro, and pathogenic potential in a chinchilla otitis media model...
  6. Kerschner J, Horsey E, Ahmed A, Erbe C, Khampang P, Cioffi J, et al. Gene expression differences in infected and noninfected middle ear complementary DNA libraries. Arch Otolaryngol Head Neck Surg. 2009;135:33-9 pubmed publisher
    ..The cDNA libraries were constructed from NTHi-infected and noninfected chinchilla MEM...
  7. Morton D, Seale T, Bakaletz L, Jurcisek J, Smith A, VanWagoner T, et al. The heme-binding protein (HbpA) of Haemophilus influenzae as a virulence determinant. Int J Med Microbiol. 2009;299:479-88 pubmed publisher
    ..The hbpA mutant of the nontypeable strain was indistinguishable from the wild-type strain in the chinchilla model of otitis media...
  8. Hong W, Juneau R, Pang B, Swords W. Survival of bacterial biofilms within neutrophil extracellular traps promotes nontypeable Haemophilus influenzae persistence in the chinchilla model for otitis media. J Innate Immun. 2009;1:215-24 pubmed publisher
    ..The presence of biofilms within the chinchilla middle-ear chamber was significantly correlated with increased bacterial load in middle-ear effusions and tissue...
  9. Hong W, Pang B, West Barnette S, Swords W. Phosphorylcholine expression by nontypeable Haemophilus influenzae correlates with maturation of biofilm communities in vitro and in vivo. J Bacteriol. 2007;189:8300-7 pubmed
    ..In vivo infection studies using the chinchilla model of otitis media showed a direct correlation between PCho expression and biofilm formation within the ..

More Information

Publications89

  1. Jurcisek J, Bakaletz L. Biofilms formed by nontypeable Haemophilus influenzae in vivo contain both double-stranded DNA and type IV pilin protein. J Bacteriol. 2007;189:3868-75 pubmed
  2. Koka K, Jones H, Thornton J, Lupo J, Tollin D. Sound pressure transformations by the head and pinnae of the adult Chinchilla (Chinchilla lanigera). Hear Res. 2011;272:135-47 pubmed publisher
    ..Although the chinchilla has been used for decades to study the anatomy, physiology, and psychophysics of audition, including binaural ..
  3. Novotny L, Mason K, Bakaletz L. Development of a chinchilla model to allow direct, continuous, biophotonic imaging of bioluminescent nontypeable Haemophilus influenzae during experimental otitis media. Infect Immun. 2005;73:609-11 pubmed
    ..Herein, we demonstrate the ability to detect bioluminescence and to monitor infection within the nasopharynges, eustachian tubes, and middle ears of chinchillas after intranasal and transbullar challenges. ..
  4. Chhan D, Roosli C, McKinnon M, Rosowski J. Evidence of inner ear contribution in bone conduction in chinchilla. Hear Res. 2013;301:66-71 pubmed publisher
    We investigated the contribution of the middle ear to the physiological response to bone conduction stimuli in chinchilla. We measured intracochlear sound pressure in response to air conduction (AC) and bone conduction (BC) stimuli before ..
  5. Chen H, Ma Y, Yang J, O Brien C, Lee S, Mazurkiewicz J, et al. Genetic requirement for pneumococcal ear infection. PLoS ONE. 2007;3:e2950 pubmed publisher
    ..Here, we report the first genome-scale in vivo screen for bacterial genes required for ear infection in a chinchilla model by signature tagged mutagenesis (STM), a high throughput mutant screen technique...
  6. Kale S, Heinz M. Envelope coding in auditory nerve fibers following noise-induced hearing loss. J Assoc Res Otolaryngol. 2010;11:657-73 pubmed publisher
    ..Overall, these data suggest the need to consider the relative effects of SNHL on envelope and fine-structure coding in evaluating perceptual deficits in temporal processing of complex stimuli. ..
  7. Morton D, Hempel R, Seale T, Whitby P, Stull T. A functional tonB gene is required for both virulence and competitive fitness in a chinchilla model of Haemophilus influenzae otitis media. BMC Res Notes. 2012;5:327 pubmed publisher
    ..Haemophilus influenzae requires heme for aerobic growth and possesses multiple mechanisms to obtain this essential nutrient...
  8. Novotny L, Jurcisek J, Godfroid F, Poolman J, Denoel P, Bakaletz L. Passive immunization with human anti-protein D antibodies induced by polysaccharide protein D conjugates protects chinchillas against otitis media after intranasal challenge with Haemophilus influenzae. Vaccine. 2006;24:4804-11 pubmed
    ..vaccines conferred approximately 34% protection against development of ascending NTHI-induced OM when used in a chinchilla viral-bacterial co-infection model...
  9. Hoopman T, Liu W, Joslin S, Pybus C, Sedillo J, Labandeira Rey M, et al. Use of the chinchilla model for nasopharyngeal colonization to study gene expression by Moraxella catarrhalis. Infect Immun. 2012;80:982-95 pubmed publisher
    ..catarrhalis to survive in the chinchilla nasopharynx over a 3-day period. This is the first evaluation of global transcriptome expression by M...
  10. Nicotera T, Hu B, Henderson D. The caspase pathway in noise-induced apoptosis of the chinchilla cochlea. J Assoc Res Otolaryngol. 2003;4:466-77 pubmed
    ..Lastly, use of the TUNEL assay in combination with PI labeling provides a more accurate discrimination between apoptosis and necrosis. ..
  11. Hong W, Peng D, Rivera M, Gu X. Protection against nontypeable Haemophilus influenzae challenges by mucosal vaccination with a detoxified lipooligosaccharide conjugate in two chinchilla models. Microbes Infect. 2010;12:11-8 pubmed publisher
    ..n. challenge model is preferable for testing the mucosal vaccines while the T.B. challenge model is superior for testing the systemic vaccines. ..
  12. Basso W, Rütten M, Deplazes P, Grimm F. Generalized Taenia crassiceps cysticercosis in a chinchilla (Chinchilla lanigera). Vet Parasitol. 2014;199:116-20 pubmed publisher
    ..One adult male chinchilla (Chinchilla lanigera) from an animal shelter in Switzerland presented widespread subcutaneous fluctuant ..
  13. Temchin A, Recio Spinoso A, Cai H, Ruggero M. Traveling waves on the organ of corti of the chinchilla cochlea: spatial trajectories of inner hair cell depolarization inferred from responses of auditory-nerve fibers. J Neurosci. 2012;32:10522-9 pubmed publisher
    Spatial magnitude and phase profiles for inner hair cell (IHC) depolarization throughout the chinchilla cochlea were inferred from responses of auditory-nerve fibers (ANFs) to threshold- and moderate-level tones and tone complexes...
  14. Vogel A, Szelestey B, Raffel F, Sharpe S, Gearinger R, Justice S, et al. SapF-mediated heme-iron utilization enhances persistence and coordinates biofilm architecture of Haemophilus. Front Cell Infect Microbiol. 2012;2:42 pubmed publisher
    ..Given the multiple essential functions provided by the Sap transporter, this complex could prove to be an effective therapeutic target for the treatment of NTHI diseases...
  15. Brockson M, Novotny L, Jurcisek J, McGillivary G, Bowers M, Bakaletz L. Respiratory syncytial virus promotes Moraxella catarrhalis-induced ascending experimental otitis media. PLoS ONE. 2012;7:e40088 pubmed publisher
    ..catarrhalis-induced ascending experimental OM. This model can be used both in studies of pathogenesis as well as to investigate strategies to prevent or treat OM due to M. catarrhalis...
  16. Yang W, Henderson D, Hu B, Nicotera T. Quantitative analysis of apoptotic and necrotic outer hair cells after exposure to different levels of continuous noise. Hear Res. 2004;196:69-76 pubmed
    ..The results of the study indicate that the early expansion of cochlear lesion is attributed primarily to apoptosis, whereas the later stage of lesion expansion is likely the result of an equal contribution from apoptosis and necrosis. ..
  17. Daines D, Bothwell M, Furrer J, Unrath W, Nelson K, Jarisch J, et al. Haemophilus influenzae luxS mutants form a biofilm and have increased virulence. Microb Pathog. 2005;39:87-96 pubmed
    ..The luxSHi mutant of an otitis media isolate, strain R3157 appeared more virulent in the chinchilla model of otitis media: there were more bacteria in the middle ear, a greater inflammatory response and more ..
  18. Bielefeld E, Hangauer D, Henderson D. Protection from impulse noise-induced hearing loss with novel Src-protein tyrosine kinase inhibitors. Neurosci Res. 2011;71:348-54 pubmed publisher
  19. Chintanpalli A, Heinz M. Effect of auditory-nerve response variability on estimates of tuning curves. J Acoust Soc Am. 2007;122:EL203-9 pubmed publisher
    ..Errors in estimates of CF, which decreased from +/-0.2 octaves at low frequencies to +/-0.05 octaves at high frequencies, are significant for studies of spatiotemporal coding. ..
  20. Kim J, Gross J, Morest D, Potashner S. Quantitative study of degeneration and new growth of axons and synaptic endings in the chinchilla cochlear nucleus after acoustic overstimulation. J Neurosci Res. 2004;77:829-42 pubmed
    ..These findings are consistent with a loss and regrowth of synaptic endings and with a reorganization of synaptic connections that favors excitation...
  21. Delano P, Elgueda D, Hamame C, Robles L. Selective attention to visual stimuli reduces cochlear sensitivity in chinchillas. J Neurosci. 2007;27:4146-53 pubmed
    ..These results demonstrate that afferent auditory activity is modulated by selective attention as early as at sensory transduction, possibly through activation of olivocochlear efferent fibers...
  22. Hullar T, Della Santina C, Hirvonen T, Lasker D, Carey J, Minor L. Responses of irregularly discharging chinchilla semicircular canal vestibular-nerve afferents during high-frequency head rotations. J Neurophysiol. 2005;93:2777-86 pubmed
    ..Reported here are responses of chinchilla semicircular canal vestibular-nerve afferents to rotational stimuli at frequencies up to 16 Hz...
  23. Cheatham M. Comment on "Mutual suppression in the 6 kHz region of sensitive chinchilla cochleae" [J. Acoust. Soc. Am. 121, 2805-2818 (2007)]. J Acoust Soc Am. 2008;123:602-5 pubmed publisher
    ..Hence, basilar membrane mechanics may well be the source of low-side suppression measured in the auditory nerve...
  24. Harrison A, Santana E, Szelestey B, Newsom D, White P, Mason K. Ferric uptake regulator and its role in the pathogenesis of nontypeable Haemophilus influenzae. Infect Immun. 2013;81:1221-33 pubmed publisher
    ..Identification of such pathways will increase our understanding of how this pathogen can persist within host microenvironments, as a common commensal and, importantly, as a pathogen with significant clinical impact...
  25. Bakaletz L. Chinchilla as a robust, reproducible and polymicrobial model of otitis media and its prevention. Expert Rev Vaccines. 2009;8:1063-82 pubmed publisher
    ..For the highly prevalent pediatric disease otitis media, or middle-ear infection, the chinchilla (Chinchilla lanigera) has served as a gold-standard rodent host system in which to study this multifactorial and ..
  26. Raffel F, Szelestey B, Beatty W, Mason K. The Haemophilus influenzae Sap transporter mediates bacterium-epithelial cell homeostasis. Infect Immun. 2013;81:43-54 pubmed publisher
    ..Furthermore, chinchilla middle ears challenged with the sapA mutant demonstrated a decrease in disease severity compared to ears ..
  27. Jurcisek J, Greiner L, Watanabe H, Zaleski A, Apicella M, Bakaletz L. Role of sialic acid and complex carbohydrate biosynthesis in biofilm formation by nontypeable Haemophilus influenzae in the chinchilla middle ear. Infect Immun. 2005;73:3210-8 pubmed
    ..NTHI forms biofilms in vitro as well as in the chinchilla middle ear, suggesting that biofilm formation in vivo might play an important role in the pathogenesis and ..
  28. Hu B, Henderson D, Nicotera T. Extremely rapid induction of outer hair cell apoptosis in the chinchilla cochlea following exposure to impulse noise. Hear Res. 2006;211:16-25 pubmed
    ..The results of the study demonstrate that induction of OHC apoptosis after the noise exposure is an extremely rapid process...
  29. Mason K, Munson R, Bakaletz L. A mutation in the sap operon attenuates survival of nontypeable Haemophilus influenzae in a chinchilla model of otitis media. Infect Immun. 2005;73:599-608 pubmed
    ..We have recently shown that sapA gene expression is upregulated in the middle ear in a chinchilla model of nontypeable Haemophilus influenzae (NTHI)-induced otitis media...
  30. Mason K, Bruggeman M, Munson R, Bakaletz L. The non-typeable Haemophilus influenzae Sap transporter provides a mechanism of antimicrobial peptide resistance and SapD-dependent potassium acquisition. Mol Microbiol. 2006;62:1357-72 pubmed
    ..product SapA is sensitive to killing by APs and is significantly attenuated in its ability to survive in a chinchilla model of otitis media compared with the parent strain...
  31. McGillivary G, Ray W, Bevins C, Munson R, Bakaletz L. A member of the cathelicidin family of antimicrobial peptides is produced in the upper airway of the chinchilla and its mRNA expression is altered by common viral and bacterial co-pathogens of otitis media. Mol Immunol. 2007;44:2446-58 pubmed
    ..OM, we cloned a cDNA encoding a cathelicidin homolog (cCRAMP) from upper respiratory tract (URT) mucosae of the chinchilla, the predominant host used to model experimental OM...
  32. Armbruster C, Pang B, Murrah K, Juneau R, Perez A, Weimer K, et al. RbsB (NTHI_0632) mediates quorum signal uptake in nontypeable Haemophilus influenzae strain 86-028NP. Mol Microbiol. 2011;82:836-50 pubmed publisher
    ..Infection studies revealed that loss of rbsB impaired bacterial persistence in the chinchilla middle ear, similar to our previous results with luxS mutants...
  33. Elgueda D, Delano P, Robles L. Effects of electrical stimulation of olivocochlear fibers in cochlear potentials in the chinchilla. J Assoc Res Otolaryngol. 2011;12:317-27 pubmed publisher
    ..The main objective of the present work was to describe these efferent effects in the chinchilla, comparing them with those in other species and in behavioral experiments...
  34. McGillivary G, Bakaletz L. The multifunctional host defense peptide SPLUNC1 is critical for homeostasis of the mammalian upper airway. PLoS ONE. 2010;5:e13224 pubmed publisher
    ..We used small interfering RNA (siRNA) technology to knock down expression of the chinchilla ortholog of human SPLUNC1 (cSPLUNC1) to begin to determine the role that this protein played in prevention of OM...
  35. Figueira M, Ram S, Goldstein R, Hood D, Moxon E, Pelton S. Role of complement in defense of the middle ear revealed by restoring the virulence of nontypeable Haemophilus influenzae siaB mutants. Infect Immun. 2007;75:325-33 pubmed
    ..in their ability to sialylate lipopolysaccharide (LPS), called siaB mutants, show attenuated virulence in a chinchilla model of experimental otitis media (EOM)...
  36. Novotny L, Adams L, Kang D, Wiet G, Cai X, Sethi S, et al. Epitope mapping immunodominant regions of the PilA protein of nontypeable Haemophilus influenzae (NTHI) to facilitate the design of two novel chimeric vaccine candidates. Vaccine. 2009;28:279-89 pubmed publisher
    We designed and tested three PilA-derived vaccine candidates in a chinchilla model of ascending nontypeable Haemophilus influenzae (NTHI)-induced otitis media (OM)...
  37. Hu B. Delayed mitochondrial dysfunction in apoptotic hair cells in chinchilla cochleae following exposure to impulse noise. Apoptosis. 2007;12:1025-36 pubmed
    ..succinate dehydrogenase (SDH) activity and mitochondrial membrane potential (MMP), were examined in HCs of chinchilla cochleae following exposure to a series of 75 pairs of impulse noises at 155 dB pSPL...
  38. Hirvonen T, Minor L, Hullar T, Carey J. Effects of intratympanic gentamicin on vestibular afferents and hair cells in the chinchilla. J Neurophysiol. 2005;93:643-55 pubmed
  39. Choi C, Chen K, Vasquez Weldon A, Jackson R, Floyd R, Kopke R. Effectiveness of 4-hydroxy phenyl N-tert-butylnitrone (4-OHPBN) alone and in combination with other antioxidant drugs in the treatment of acute acoustic trauma in chinchilla. Free Radic Biol Med. 2008;44:1772-84 pubmed publisher
    ..b>Chinchilla were exposed to a 105 dB octave-band noise centered at 4 kHz for 6 h...
  40. Roehm P, Hoffer M, Balaban C. Gentamicin uptake in the chinchilla inner ear. Hear Res. 2007;230:43-52 pubmed
    ..application of gentamicin was performed by either minipump (Alza model, 2002) or transtympanic injection in a chinchilla model...
  41. Morton D, Bakaletz L, Jurcisek J, VanWagoner T, Seale T, Whitby P, et al. Reduced severity of middle ear infection caused by nontypeable Haemophilus influenzae lacking the hemoglobin/hemoglobin-haptoglobin binding proteins (Hgp) in a chinchilla model of otitis media. Microb Pathog. 2004;36:25-33 pubmed
    ..influenzae mutant lacking all the hgp genes was constructed and compared to the wild-type strain in a chinchilla (Chinchilla lanigera) model of otitis media...
  42. Jones H, Koka K, Thornton J, Tollin D. Concurrent development of the head and pinnae and the acoustical cues to sound location in a precocious species, the chinchilla (Chinchilla lanigera). J Assoc Res Otolaryngol. 2011;12:127-40 pubmed publisher
    ..The dimension of the head and pinnae in the chinchilla as well as the acoustical properties associated with them are mature by ~6 weeks.
  43. Songer J, Rosowski J. A mechano-acoustic model of the effect of superior canal dehiscence on hearing in chinchilla. J Acoust Soc Am. 2007;122:943-51 pubmed
    ..The effect of SCD (a hole in the bony wall of the superior semicircular canal) on chinchilla middle- and inner-ear mechanics is analyzed with a circuit model of the dehiscence...
  44. Luke N, Jurcisek J, Bakaletz L, Campagnari A. Contribution of Moraxella catarrhalis type IV pili to nasopharyngeal colonization and biofilm formation. Infect Immun. 2007;75:5559-64 pubmed
    ..catarrhalis and an isogenic TFP mutant to colonize the nasopharynx of the chinchilla. These results suggest that the expression of TFP contributes to mucosal airway colonization...
  45. Bielefeld E, Henderson D. Influence of sympathetic fibers on noise-induced hearing loss in the chinchilla. Hear Res. 2007;223:11-9 pubmed
    ..study, we explore the effects of unilateral and bilateral Superior Cervical Ganglion (SCG) ablation in the chinchilla on hearing loss from noise exposure, as measured with inferior colliculus (IC) evoked potentials, distortion ..
  46. Armbruster C, Hong W, Pang B, Dew K, Juneau R, Byrd M, et al. LuxS promotes biofilm maturation and persistence of nontypeable haemophilus influenzae in vivo via modulation of lipooligosaccharides on the bacterial surface. Infect Immun. 2009;77:4081-91 pubmed publisher
    ..of luxS, a determinant of the autoinducer 2 (AI-2) quorum signal pathway, increases NTHI virulence in the chinchilla model for otitis media infections...
  47. McGillivary G, Mason K, Jurcisek J, Peeples M, Bakaletz L. Respiratory syncytial virus-induced dysregulation of expression of a mucosal beta-defensin augments colonization of the upper airway by non-typeable Haemophilus influenzae. Cell Microbiol. 2009;11:1399-408 pubmed publisher
    ..virus (RSV), a viral co-pathogen of OM, reduces transcript abundance of the antimicrobial peptide (AP), chinchilla beta-defensin-1 (cBD-1)...
  48. Rhode W. Basilar membrane mechanics in the 6-9 kHz region of sensitive chinchilla cochleae. J Acoust Soc Am. 2007;121:2792-804 pubmed
    The vibration of the basilar membrane in the 6-9 kHz region in the chinchilla cochlea has been studied using a displacement sensitive interferometer. Displacements of 0.7-1.4 nm at 0 dB sound pressure level have been obtained...
  49. Yost W, Shofner W. Critical bands and critical ratios in animal psychoacoustics: an example using chinchilla data. J Acoust Soc Am. 2009;125:315-23 pubmed publisher
    ..A probe-tone detection study using chinchilla subjects suggests that they may be broadband processors in detection tasks as opposed to human subjects who use ..
  50. Levecke B, Meulemans L, Dalemans T, Casaert S, Claerebout E, Geurden T. Mixed Giardia duodenalis assemblage A, B, C and E infections in pet chinchillas (Chinchilla lanigera) in Flanders (Belgium). Vet Parasitol. 2011;177:166-70 pubmed publisher
    ..To this end, pet chinchillas (Chinchilla lanigera) from both pet owners and breeders in Flanders (Belgium) were screened for the presence of Giardia spp...
  51. Hu B, Zheng G. Membrane disruption: an early event of hair cell apoptosis induced by exposure to intense noise. Brain Res. 2008;1239:107-18 pubmed publisher
    ..Notably, despite the membrane damage, hair cells continue to undergo the apoptotic process, leading to the generation of a type of apoptosis with early membrane damage...
  52. Kerschner J, Meyer T, Burrows A. Chinchilla middle ear epithelial mucin gene expression in response to inflammatory cytokines. Arch Otolaryngol Head Neck Surg. 2004;130:1163-7 pubmed
  53. Lundström S, Li J, Månsson M, Figueira M, Leroy M, Goldstein R, et al. Application of capillary electrophoresis mass spectrometry and liquid chromatography multiple-step tandem electrospray mass spectrometry to profile glycoform expression during Haemophilus influenzae pathogenesis in the chinchilla model of experimenta. Infect Immun. 2008;76:3255-67 pubmed publisher
    ..determined LPS glycoform populations from NTHi strain 1003 during the course of experimental otitis media in the chinchilla model of infection by mass spectrometric techniques...
  54. Bookwalter J, Jurcisek J, Gray Owen S, Fernandez S, McGillivary G, Bakaletz L. A carcinoembryonic antigen-related cell adhesion molecule 1 homologue plays a pivotal role in nontypeable Haemophilus influenzae colonization of the chinchilla nasopharynx via the outer membrane protein P5-homologous adhesin. Infect Immun. 2008;76:48-55 pubmed
    ..NTHI), the outer membrane protein P5-homologous adhesin (or P5), is essential for colonization of the chinchilla nasopharynx and infection of the middle ear...
  55. Gitiban N, Jurcisek J, Harris R, Mertz S, Durbin R, Bakaletz L, et al. Chinchilla and murine models of upper respiratory tract infections with respiratory syncytial virus. J Virol. 2005;79:6035-42 pubmed
    ..Herein, we describe mouse and chinchilla models of RSV infection of the nasopharynx and Eustachian tube...
  56. Szalda K, Burkard R. The effects of nembutal anesthesia on the auditory steady-state response (ASSR) from the inferior colliculus and auditory cortex of the chinchilla. Hear Res. 2005;203:32-44 pubmed
    ..of the auditory steady-state response (ASSR) in the inferior colliculus (IC) and auditory cortex (AC) of the chinchilla. Tungsten electrodes were chronically implanted following anesthesia with ketamine/acepromazine...
  57. Du X, Chen K, Choi C, Li W, Cheng W, Stewart C, et al. Selective degeneration of synapses in the dorsal cochlear nucleus of chinchilla following acoustic trauma and effects of antioxidant treatment. Hear Res. 2012;283:1-13 pubmed publisher
    ..activity markers (synaptophysin and precerebellin) and ultrastructure of synapses were examined in the DCN of chinchilla 10 days after a 105 dB SPL octave-band noise (centered at 4 kHz, 6 h) exposure...
  58. Chen S, Paterson G, Tong H, Mitchell T, DeMaria T. Sortase A contributes to pneumococcal nasopharyngeal colonization in the chinchilla model. FEMS Microbiol Lett. 2005;253:151-4 pubmed
    ..We examined the role of SrtA in Streptococcus pneumoniae nasopharyngeal (NP) colonization in the chinchilla model...
  59. Muir G, Brown J, Carey J, Hirvonen T, Della Santina C, Minor L, et al. Disruption of the head direction cell signal after occlusion of the semicircular canals in the freely moving chinchilla. J Neurosci. 2009;29:14521-33 pubmed publisher
  60. Hoffer M, Finley J, Killian P, Gottshall K, Balough B, Wester D, et al. Sustained-release delivery of leupeptin in the chinchilla: hearing results. Int Tinnitus J. 2003;9:76-8 pubmed
    ..The medicine produced no hearing loss at the early time points but did produce some hearing loss at later time points. We discuss these results and begin to outline the next steps in the investigation of this agent...
  61. Pienkowski M, Harrison R. Tone frequency maps and receptive fields in the developing chinchilla auditory cortex. J Neurophysiol. 2005;93:454-66 pubmed
    ..from numerous microelectrode penetrations of auditory cortex (under ketamine anesthesia) in the developing chinchilla (laniger), a precocious mammal...
  62. Harding G, Bohne B. Relation of focal hair-cell lesions to noise-exposure parameters from a 4- or a 0.5-kHz octave band of noise. Hear Res. 2009;254:54-63 pubmed publisher
    ..and the percentage losses of outer (OHC) and inner (IHC) hair cells in the basal and apical halves of 607 chinchilla cochleae [Harding, G.W., Bohne, B.A., 2004a...
  63. Hong W, Mason K, Jurcisek J, Novotny L, Bakaletz L, Swords W. Phosphorylcholine decreases early inflammation and promotes the establishment of stable biofilm communities of nontypeable Haemophilus influenzae strain 86-028NP in a chinchilla model of otitis media. Infect Immun. 2007;75:958-65 pubmed
    ..isolate (NTHi strain 86-028NP) was compared with that of an isogenic PCho transferase (licD) mutant using a chinchilla (Chinchilla lanigera) model of otitis media...
  64. Bouchet V, Hood D, Li J, Brisson J, Randle G, Martin A, et al. Host-derived sialic acid is incorporated into Haemophilus influenzae lipopolysaccharide and is a major virulence factor in experimental otitis media. Proc Natl Acad Sci U S A. 2003;100:8898-903 pubmed
    ..In contrast, LPS of ex vivo organisms recovered from chinchilla middle ear exudates was sialylated...
  65. Harris R, Wilk D, Bevins C, Munson R, Bakaletz L. Identification and characterization of a mucosal antimicrobial peptide expressed by the chinchilla (Chinchilla lanigera) airway. J Biol Chem. 2004;279:20250-6 pubmed
    ..our goal was to identify and characterize APs expressed by the epithelium lining the uppermost airway of the chinchilla, the established rodent host for the study of the bacterial-viral pathogenesis in OM...
  66. Busso J, Ponzio M, Chiaraviglio M, Fiol de Cuneo M, Ruiz R. Electroejaculation in the Chinchilla (Chinchilla lanigera): effects of anesthesia on seminal characteristics. Res Vet Sci. 2005;78:93-7 pubmed
    ..m.) on a method of electroejaculation used previously in conscious chinchillas (Chinchilla lanigera), and (b) determine the quality of the electroejaculated semen obtained under anesthesia...
  67. Buchinsky F, Forbes M, Hayes J, Shen K, Ezzo S, Compliment J, et al. Virulence phenotypes of low-passage clinical isolates of nontypeable Haemophilus influenzae assessed using the chinchilla laniger model of otitis media. BMC Microbiol. 2007;7:56 pubmed
    ..These diverse clinical and genotypic findings suggest that each NTHi strain possesses a unique set of virulence factors that contributes to the course of the disease...
  68. Recio Spinoso A, Narayan S, Ruggero M. Basilar membrane responses to noise at a basal site of the chinchilla cochlea: quasi-linear filtering. J Assoc Res Otolaryngol. 2009;10:471-84 pubmed publisher
    ..membrane responses to clicks and to white noise were recorded using laser velocimetry at basal sites of the chinchilla cochlea with characteristic frequencies near 10 kHz...
  69. Shera C, Tubis A, Talmadge C. Testing coherent reflection in chinchilla: Auditory-nerve responses predict stimulus-frequency emissions. J Acoust Soc Am. 2008;124:381-95 pubmed publisher
    ..derived from Wiener-kernel analysis of auditory-nerve responses allow for comprehensive tests of the theory in chinchilla. Model predictions are based on (1) an approximate analytic expression for the SFOAE signal in terms of the BM ..
  70. Forbes M, Horsey E, Hiller N, Buchinsky F, Hayes J, Compliment J, et al. Strain-specific virulence phenotypes of Streptococcus pneumoniae assessed using the Chinchilla laniger model of otitis media. PLoS ONE. 2008;3:e1969 pubmed publisher
    ..Using the chinchilla model of otitis media [OM] we investigated the disease phenotype generated by the laboratory strain TIGR4 and ..
  71. Harding G, Bohne B. Distribution of focal lesions in the chinchilla organ of Corti following exposure to a 4-kHz or a 0.5-kHz octave band of noise. Hear Res. 2007;225:50-9 pubmed
    ..resolution power spectrum analysis of each OBN and non-invasive tests for harmonics and distortion products in a chinchilla were performed to look for exposure energy above and below the OBN...
  72. Shofner W, Yost W, Whitmer W. Pitch perception in chinchillas (Chinchilla laniger): stimulus generalization using rippled noise. J Comp Psychol. 2007;121:428-39 pubmed
    ..Chinchillas (Chinchilla laniger) were trained to discriminate IIRN[+] with a 4-ms delay from IIRN[+] with a 2-ms delay and then tested ..
  73. Jurcisek J, Bookwalter J, Baker B, Fernandez S, Novotny L, Munson R, et al. The PilA protein of non-typeable Haemophilus influenzae plays a role in biofilm formation, adherence to epithelial cells and colonization of the mammalian upper respiratory tract. Mol Microbiol. 2007;65:1288-99 pubmed
    ..demonstrated a role for NTHI PilA in adherence to human respiratory epithelial cells, in colonization of the chinchilla respiratory tract as well as a requirement for PilA in biofilm development, both in vitro and in vivo...
  74. Shelton C, Raffel F, Beatty W, Johnson S, Mason K. Sap transporter mediated import and subsequent degradation of antimicrobial peptides in Haemophilus. PLoS Pathog. 2011;7:e1002360 pubmed publisher
    ..These data support a mechanism of Sap mediated import of AMPs, a novel strategy to reduce periplasmic and inner membrane accumulation of these host defense peptides...
  75. Shera C, Guinan J, Oxenham A. Otoacoustic estimation of cochlear tuning: validation in the chinchilla. J Assoc Res Otolaryngol. 2010;11:343-65 pubmed publisher
    We analyze published auditory-nerve and otoacoustic measurements in chinchilla to test a network of hypothesized relationships between cochlear tuning, cochlear traveling-wave delay, and stimulus-frequency otoacoustic emissions (SFOAEs)...
  76. Kerschner J, Erdos G, Hu F, Burrows A, Cioffi J, Khampang P, et al. Partial characterization of normal and Haemophilus influenzae-infected mucosal complementary DNA libraries in chinchilla middle ear mucosa. Ann Otol Rhinol Laryngol. 2010;119:270-8 pubmed publisher
    ..b>Chinchilla MEM was harvested from controls and after middle ear inoculation with nontypeable Haemophilus influenzae...
  77. Nowicki M, Wojtkiewicz J, Seremak B, Sulik M, Ostaszewski J, Lewczuk B, et al. Specific distribution pattern of nerve fibers containing catecholamine-synthesizing enzymes, neuropeptide Y (NPY) and C-terminal flanking peptide of NPY (CPON) in the pineal gland of the chinchilla (Chinchilla laniger)--an immunohistochemical study. Folia Histochem Cytobiol. 2003;41:193-200 pubmed
    ..hydroxylase (TH), dopamine beta-hydroxylase (DbetaH) as well as NPY and CPON in the nerve fibers supplying the chinchilla pineal gland. Ten two-year-old female chinchillas housed in natural light conditions were used in the study...
  78. Rhode W. Mutual suppression in the 6 kHz region of sensitive chinchilla cochleae. J Acoust Soc Am. 2007;121:2805-18 pubmed
    ..interferometer for single-tone and two-tone suppression (2TS) paradigms in the 6-9 kHz region of sensitive chinchilla cochleae that had gains near or better than 60 dB...
  79. Ramkumar V, Whitworth C, Pingle S, Hughes L, Rybak L. Noise induces A1 adenosine receptor expression in the chinchilla cochlea. Hear Res. 2004;188:47-56 pubmed
    ..noise exposure could induce oxidative stress and determine whether this induces expression of the A1AR in the chinchilla cochlea...
  80. Bremen P, Joris P. Axonal recordings from medial superior olive neurons obtained from the lateral lemniscus of the chinchilla (Chinchilla laniger). J Neurosci. 2013;33:17506-18 pubmed publisher
    ..circumvented these difficulties by recording from the axons of MSO neurons in the lateral lemniscus (LL) of the chinchilla, a species with pronounced low-frequency sensitivity...