Summary: Members of the species Homo sapiens.

Top Publications

  1. Clarke H, Chambers J, Liniker E, Marciniak S. Endoplasmic reticulum stress in malignancy. Cancer Cell. 2014;25:563-73 pubmed publisher
    ..In this review, we examine the evidence implicating endoplasmic reticulum dysfunction in the pathology of cancer and discuss how recent findings may help to identify novel therapeutic targets. ..
  2. Sutterwala F, Haasken S, CASSEL S. Mechanism of NLRP3 inflammasome activation. Ann N Y Acad Sci. 2014;1319:82-95 pubmed publisher
    ..This review highlights our current understanding of the mechanisms of both priming and activation of the NLRP3 inflammasome. ..
  3. Kingwell B, Chapman M, Kontush A, Miller N. HDL-targeted therapies: progress, failures and future. Nat Rev Drug Discov. 2014;13:445-64 pubmed publisher
    ..This article examines the HDL hypothesis in molecular and mechanistic terms, focusing on features that have been addressed, those that remain to be tested, and potential new targets for future pharmacological interventions. ..
  4. Patel A, Tirosh I, Trombetta J, Shalek A, Gillespie S, Wakimoto H, et al. Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma. Science. 2014;344:1396-401 pubmed publisher
    ..Thus, we reveal previously unappreciated heterogeneity in diverse regulatory programs central to glioblastoma biology, prognosis, and therapy. ..
  5. O DONNELL M, Mente A, Rangarajan S, McQueen M, Wang X, Liu L, et al. Urinary sodium and potassium excretion, mortality, and cardiovascular events. N Engl J Med. 2014;371:612-23 pubmed publisher
    ..The optimal range of sodium intake for cardiovascular health is controversial...
  6. Shin S, Fauman E, Petersen A, Krumsiek J, Santos R, Huang J, et al. An atlas of genetic influences on human blood metabolites. Nat Genet. 2014;46:543-550 pubmed publisher
    ..Our findings provide new insights into the role of inherited variation in blood metabolic diversity and identify potential new opportunities for drug development and for understanding disease...
  7. Ali F, Cheng K, Kirwan P, Metcalfe S, Livesey F, Barker R, et al. The phosphorylation status of Ascl1 is a key determinant of neuronal differentiation and maturation in vivo and in vitro. Development. 2014;141:2216-24 pubmed publisher
  8. Sanders D, Kaufman S, DeVos S, Sharma A, Mirbaha H, Li A, et al. Distinct tau prion strains propagate in cells and mice and define different tauopathies. Neuron. 2014;82:1271-88 pubmed publisher
    ..Tau thus demonstrates essential characteristics of a prion. This might explain the phenotypic diversity of tauopathies and could enable more effective diagnosis and therapy...
  9. Fan L, Strasser Weippl K, Li J, St Louis J, Finkelstein D, Yu K, et al. Breast cancer in China. Lancet Oncol. 2014;15:e279-89 pubmed publisher
    ..Finally, we recommend key measures that could contribute to improved health outcomes for patients with breast cancer in China. ..

More Information

Publications108 found, 100 shown here

  1. Martin C, Ahmad I, Klingseisen A, Hussain M, Bicknell L, Leitch A, et al. Mutations in PLK4, encoding a master regulator of centriole biogenesis, cause microcephaly, growth failure and retinopathy. Nat Genet. 2014;46:1283-1292 pubmed publisher
    ..Furthermore, we establish that different levels of impaired PLK4 activity result in growth and cilia phenotypes, providing a mechanism by which microcephaly disorders can occur with or without ciliopathic features. ..
  2. Wartolowska K, Judge A, Hopewell S, Collins G, Dean B, Rombach I, et al. Use of placebo controls in the evaluation of surgery: systematic review. BMJ. 2014;348:g3253 pubmed publisher
    ..In half of the studies, the results provide evidence against continued use of the investigated surgical procedures. Without well designed placebo controlled trials of surgery, ineffective treatment may continue unchallenged. ..
  3. Florea V, Cohn J. The autonomic nervous system and heart failure. Circ Res. 2014;114:1815-26 pubmed publisher
  4. Sjöström L, Peltonen M, Jacobson P, Ahlin S, Andersson Assarsson J, Anveden Å, et al. Association of bariatric surgery with long-term remission of type 2 diabetes and with microvascular and macrovascular complications. JAMA. 2014;311:2297-304 pubmed publisher
    ..These findings require confirmation in randomized trials. TRIAL REGISTRATION Identifier: NCT01479452. ..
  5. Easwaran H, Tsai H, Baylin S. Cancer epigenetics: tumor heterogeneity, plasticity of stem-like states, and drug resistance. Mol Cell. 2014;54:716-27 pubmed publisher
    ..In this review, we discuss the possible role of epigenetic abnormalities as well as genetic alterations in such dynamics and in the creation of cellular heterogeneity in cancers of all types. ..
  6. Muñoz Espín D, Serrano M. Cellular senescence: from physiology to pathology. Nat Rev Mol Cell Biol. 2014;15:482-96 pubmed publisher
    ..Conversely, antisenescent therapies may help to eliminate accumulated senescent cells and to recover tissue function. ..
  7. Templeton A, McNamara M, Seruga B, Vera Badillo F, Aneja P, Ocana A, et al. Prognostic role of neutrophil-to-lymphocyte ratio in solid tumors: a systematic review and meta-analysis. J Natl Cancer Inst. 2014;106:dju124 pubmed publisher
    ..Here we quantify the prognostic impact of this biomarker and assess its consistency in solid tumors...
  8. Tania M, Khan M, Fu J. Epithelial to mesenchymal transition inducing transcription factors and metastatic cancer. Tumour Biol. 2014;35:7335-42 pubmed publisher
    ..This review summarizes the update information on the association of EMT-TFs with cancer metastasis and the possible cancer therapeutics via targeting the EMT-TFs. ..
  9. Beer T, Armstrong A, Rathkopf D, Loriot Y, Sternberg C, Higano C, et al. Enzalutamide in metastatic prostate cancer before chemotherapy. N Engl J Med. 2014;371:424-33 pubmed publisher
    ..New treatment options are needed for patients with metastatic prostate cancer who have not received chemotherapy, in whom the disease has progressed despite androgen-deprivation therapy...
  10. Idele P, Gillespie A, Porth T, Suzuki C, Mahy M, Kasedde S, et al. Epidemiology of HIV and AIDS among adolescents: current status, inequities, and data gaps. J Acquir Immune Defic Syndr. 2014;66 Suppl 2:S144-53 pubmed publisher
    ..To examine levels and patterns of HIV prevalence, knowledge, sexual behavior, and coverage of selected HIV services among adolescents aged 10-19 years and highlight data gaps and challenges...
  11. Murad M, Montori V, Ioannidis J, Jaeschke R, Devereaux P, Prasad K, et al. How to read a systematic review and meta-analysis and apply the results to patient care: users' guides to the medical literature. JAMA. 2014;312:171-9 pubmed publisher
    ..Shared decision making requires understanding of the estimates of magnitude of beneficial and harmful effects, and confidence in those estimates. ..
  12. Lamkanfi M, Dixit V. Mechanisms and functions of inflammasomes. Cell. 2014;157:1013-22 pubmed publisher
    ..This Review summarizes recent insights into inflammasome biology and discusses the questions that remain in the field. ..
  13. Pietrobon D, Moskowitz M. Chaos and commotion in the wake of cortical spreading depression and spreading depolarizations. Nat Rev Neurosci. 2014;15:379-93 pubmed publisher
  14. Dahlmann M, Okhrimenko A, Marcinkowski P, Osterland M, Herrmann P, Smith J, et al. RAGE mediates S100A4-induced cell motility via MAPK/ERK and hypoxia signaling and is a prognostic biomarker for human colorectal cancer metastasis. Oncotarget. 2014;5:3220-33 pubmed
    ..Thus, therapeutic approaches targeting RAGE or intervening in S100A4-RAGE-dependent signaling early in tumor progression might represent alternative strategies restricting S100A4-induced colorectal cancer metastasis. ..
  15. Grassart A, Cheng A, Hong S, Zhang F, Zenzer N, Feng Y, et al. Actin and dynamin2 dynamics and interplay during clathrin-mediated endocytosis. J Cell Biol. 2014;205:721-35 pubmed publisher
    ..Collectively, our results demonstrate precise temporal and quantitative regulation of the dynamin2 recruitment influenced by actin polymerization. ..
  16. Ohkawa T, Satake S, Yokoi N, Miyazaki Y, Ohshita T, Sobue G, et al. Identification and characterization of GABA(A) receptor autoantibodies in autoimmune encephalitis. J Neurosci. 2014;34:8151-63 pubmed publisher
    ..Therefore, this study establishes anti-GABA(A) receptor encephalitis and expands the pathogenic roles of GABA(A) receptor autoantibodies...
  17. Yu M, Bardia A, Aceto N, Bersani F, Madden M, Donaldson M, et al. Cancer therapy. Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility. Science. 2014;345:216-20 pubmed publisher
    ..With optimization of CTC culture conditions, this strategy may help identify the best therapies for individual cancer patients over the course of their disease. ..
  18. Jacobson I, Dore G, Foster G, Fried M, Radu M, Rafalsky V, et al. Simeprevir with pegylated interferon alfa 2a plus ribavirin in treatment-naive patients with chronic hepatitis C virus genotype 1 infection (QUEST-1): a phase 3, randomised, double-blind, placebo-controlled trial. Lancet. 2014;384:403-13 pubmed publisher
    ..The efficacy and safety of the combination of simeprevir, a one pill, once-daily, oral HCV NS3/4A protease inhibitor, plus peginterferon alfa 2a plus ribavirin were assessed in treatment-naive patients with HCV genotype 1 infection...
  19. Paszek M, DuFort C, Rossier O, Bainer R, Mouw J, Godula K, et al. The cancer glycocalyx mechanically primes integrin-mediated growth and survival. Nature. 2014;511:319-25 pubmed publisher
    ..Thus, a bulky glycocalyx is a feature of tumour cells that could foster metastasis by mechanically enhancing cell-surface receptor function. ..
  20. King T, Bradford W, Castro Bernardini S, Fagan E, Glaspole I, Glassberg M, et al. A phase 3 trial of pirfenidone in patients with idiopathic pulmonary fibrosis. N Engl J Med. 2014;370:2083-92 pubmed publisher
    ..We sought to confirm the beneficial effect of pirfenidone on disease progression in such patients...
  21. Lenders J, Duh Q, Eisenhofer G, Gimenez Roqueplo A, Grebe S, Murad M, et al. Pheochromocytoma and paraganglioma: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2014;99:1915-42 pubmed publisher
    ..The aim was to formulate clinical practice guidelines for pheochromocytoma and paraganglioma (PPGL)...
  22. Holman R, Sourij H, Califf R. Cardiovascular outcome trials of glucose-lowering drugs or strategies in type 2 diabetes. Lancet. 2014;383:2008-17 pubmed publisher
  23. Wu P, Wu D, Ni C, Ye J, Chen W, Hu G, et al. ??T17 cells promote the accumulation and expansion of myeloid-derived suppressor cells in human colorectal cancer. Immunity. 2014;40:785-800 pubmed publisher
    ..These findings suggest that ??T17 cells might be key players in human CRC progression and have the potential for treatment or prognosis prediction. ..
  24. Zhou H, Lai Y, Shan Z, Jia W, Yang W, Lu J, et al. Effectiveness of different waist circumference cut-off values in predicting metabolic syndrome prevalence and risk factors in adults in China. Biomed Environ Sci. 2014;27:325-34 pubmed publisher
    ..Conclusion Using both the modified IDF criteria and ethnicity-specific cut-off values of waist circumference can provide more useful information about the prevalence of MetS in China. ..
  25. Ashley E, Dhorda M, Fairhurst R, Amaratunga C, Lim P, Suon S, et al. Spread of artemisinin resistance in Plasmodium falciparum malaria. N Engl J Med. 2014;371:411-23 pubmed publisher
    ..Funded by the U.K. Department of International Development and others; number, NCT01350856.). ..
  26. Cunningham J, Moreno M, Lodi A, Ronen S, Ruggero D. Protein and nucleotide biosynthesis are coupled by a single rate-limiting enzyme, PRPS2, to drive cancer. Cell. 2014;157:1088-103 pubmed publisher
    ..Together, these studies identify a translationally anchored anabolic circuit critical for cancer cell survival and an unexpected vulnerability for "undruggable" oncogenes, such as Myc. PAPERFLICK:..
  27. AIZER A, Currie J. The intergenerational transmission of inequality: maternal disadvantage and health at birth. Science. 2014;344:856-61 pubmed publisher
    ..The most likely explanation is increasing knowledge about determinants of infant health and how to protect it along with public policies that put this knowledge into practice. ..
  28. Barozzi I, Simonatto M, Bonifacio S, Yang L, Rohs R, Ghisletti S, et al. Coregulation of transcription factor binding and nucleosome occupancy through DNA features of mammalian enhancers. Mol Cell. 2014;54:844-857 pubmed publisher
    ..1 binding and nucleosome occupancy genome-wide. These data reveal a basic organizational principle of mammalian cis-regulatory elements whereby TF recruitment and nucleosome deposition are controlled by overlapping DNA sequence features. ..
  29. Martins V, Busch K, Juraeva D, Blum C, Ludwig C, Rasche V, et al. Cell competition is a tumour suppressor mechanism in the thymus. Nature. 2014;509:465-70 pubmed publisher
  30. Qiang L, Zhao B, Ming M, Wang N, He T, Hwang S, et al. Regulation of cell proliferation and migration by p62 through stabilization of Twist1. Proc Natl Acad Sci U S A. 2014;111:9241-6 pubmed publisher
  31. Steenbergen R, Snijders P, Heideman D, Meijer C. Clinical implications of (epi)genetic changes in HPV-induced cervical precancerous lesions. Nat Rev Cancer. 2014;14:395-405 pubmed publisher
    ..On the basis of (epi)genetic changes, early and advanced transforming CIN lesions can be distinguished. This paves the way for new molecular tools for cervical screening, diagnosis and management of cervical cancer precursor lesions. ..
  32. Medland S, Jahanshad N, Neale B, Thompson P. Whole-genome analyses of whole-brain data: working within an expanded search space. Nat Neurosci. 2014;17:791-800 pubmed publisher
    ..We recommend a rigorous approach to neuroimaging genomics that capitalizes on its recent successes and ensures the reliability of future discoveries. ..
  33. Robertson C, Hannay H, Yamal J, Gopinath S, Goodman J, Tilley B, et al. Effect of erythropoietin and transfusion threshold on neurological recovery after traumatic brain injury: a randomized clinical trial. JAMA. 2014;312:36-47 pubmed publisher
    ..There is limited information about the effect of erythropoietin or a high hemoglobin transfusion threshold after a traumatic brain injury...
  34. Zhang T, Zhang L, Zhang T, Fan J, Wu K, Guan Z, et al. Metformin sensitizes prostate cancer cells to radiation through EGFR/p-DNA-PKCS in vitro and in vivo. Radiat Res. 2014;181:641-9 pubmed publisher
    ..Our results indicate that metformin enhances prostate cancer cell radiosensitivity in vitro and in vivo. Exposure to metformin before radiation therapy could be a beneficial option for the treatment of prostate cancer. ..
  35. Perry R, Samuel V, Petersen K, Shulman G. The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes. Nature. 2014;510:84-91 pubmed publisher
    ..Studies in mice and humans have elucidated a key role for hepatic diacylglycerol activation of protein kinase C? in triggering hepatic ..
  36. Sanna T, Diener H, Passman R, Di Lazzaro V, Bernstein R, Morillo C, et al. Cryptogenic stroke and underlying atrial fibrillation. N Engl J Med. 2014;370:2478-86 pubmed publisher
    ..3; 95% CI, 2.6 to 20.8; P<0.001). ECG monitoring with an ICM was superior to conventional follow-up for detecting atrial fibrillation after cryptogenic stroke. (Funded by Medtronic; CRYSTAL AF number, NCT00924638.). ..
  37. Klistorner A, Sriram P, Vootakuru N, Wang C, Barnett M, Garrick R, et al. Axonal loss of retinal neurons in multiple sclerosis associated with optic radiation lesions. Neurology. 2014;82:2165-72 pubmed publisher
    ..The results demonstrate a strong tract-specific association between loss of tRNFL fibers and MS-related inflammation within OR. ..
  38. Wang K, Yuen S, Xu J, Lee S, Yan H, Shi S, et al. Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer. Nat Genet. 2014;46:573-82 pubmed publisher
    ..These findings illustrate a multidimensional and comprehensive genomic landscape that highlights the molecular complexity of gastric cancer and provides a road map to facilitate genome-guided personalized therapy...
  39. Ginhoux F, Jung S. Monocytes and macrophages: developmental pathways and tissue homeostasis. Nat Rev Immunol. 2014;14:392-404 pubmed publisher
    ..In this Review, we discuss the evidence that has dramatically changed our understanding of monocyte and macrophage development, and the maintenance of these cells in the steady state...
  40. Sharma R, Pollock K, Hubel A, McKenna D. Mesenchymal stem or stromal cells: a review of clinical applications and manufacturing practices. Transfusion. 2014;54:1418-37 pubmed publisher
    ..To ensure the greatest likelihood of success in clinical trials as the field progresses, attention must be given to the optimization of MSC culture. ..
  41. Ma C, Nong K, Zhu H, Wang W, Huang X, Yuan Z, et al. H19 promotes pancreatic cancer metastasis by derepressing let-7's suppression on its target HMGA2-mediated EMT. Tumour Biol. 2014;35:9163-9 pubmed publisher
    ..This study suggests an important role of H19 in regulating metastasis of PDAC and provides some clues for elucidating the lncRNA-miRNA functional network in cancer...
  42. Lambert N, Robertson A, Jangi M, McGeary S, Sharp P, Burge C. RNA Bind-n-Seq: quantitative assessment of the sequence and structural binding specificity of RNA binding proteins. Mol Cell. 2014;54:887-900 pubmed publisher
    ..Together, our data demonstrate that RBNS complements crosslinking-based methods and show that in vivo binding and activity of these splicing factors is driven largely by intrinsic RNA affinity...
  43. Pearse R, Harrison D, MacDonald N, Gillies M, Blunt M, Ackland G, et al. Effect of a perioperative, cardiac output-guided hemodynamic therapy algorithm on outcomes following major gastrointestinal surgery: a randomized clinical trial and systematic review. JAMA. 2014;311:2181-90 pubmed publisher
    ..Small trials suggest that postoperative outcomes may be improved by the use of cardiac output monitoring to guide administration of intravenous fluid and inotropic drugs as part of a hemodynamic therapy algorithm...
  44. Celiz A, Smith J, Langer R, Anderson D, Winkler D, Barrett D, et al. Materials for stem cell factories of the future. Nat Mater. 2014;13:570-9 pubmed publisher
    ..In this Review, we consider the role of materials discovery, an emerging area of materials chemistry that is in large part driven by the challenges posed by biologists to materials scientists. ..
  45. Spires Jones T, Hyman B. The intersection of amyloid beta and tau at synapses in Alzheimer's disease. Neuron. 2014;82:756-71 pubmed publisher
    ..These two key phenomena, synapse loss and the spread of pathology through the brain via synapses, make it critical to understand the physiological and pathological roles of amyloid beta and tau at the synapse. ..
  46. Andersson D, Hughes D. Microbiological effects of sublethal levels of antibiotics. Nat Rev Microbiol. 2014;12:465-78 pubmed publisher
    The widespread use of antibiotics results in the generation of antibiotic concentration gradients in humans, livestock and the environment...
  47. Jin C, Lu Y, Jelinek J, Liang S, Estecio M, Barton M, et al. TET1 is a maintenance DNA demethylase that prevents methylation spreading in differentiated cells. Nucleic Acids Res. 2014;42:6956-71 pubmed publisher
    ..Thus, our results identify TET1 as a maintenance DNA demethylase that does not purposely decrease methylation levels, but specifically prevents aberrant methylation spreading into CGIs in differentiated cells. ..
  48. Subramanian S, Huq S, Yatsunenko T, Haque R, Mahfuz M, alam M, et al. Persistent gut microbiota immaturity in malnourished Bangladeshi children. Nature. 2014;510:417-21 pubmed publisher
    ..More prolonged interventions with existing or new therapeutic foods and/or addition of gut microbes may be needed to achieve enduring repair of gut microbiota immaturity in childhood malnutrition and improve clinical outcomes. ..
  49. Leslie T, Mikhail A, Mayan I, Cundill B, Anwar M, Bakhtash S, et al. Rapid diagnostic tests to improve treatment of malaria and other febrile illnesses: patient randomised effectiveness trial in primary care clinics in Afghanistan. BMJ. 2014;348:g3730 pubmed publisher
    ..To assess the impact of rapid diagnostic tests on the diagnostic accuracy and treatment of malaria and non-severe fever in an Asian setting...
  50. MacPherson P, Lalloo D, Webb E, Maheswaran H, Choko A, Makombe S, et al. Effect of optional home initiation of HIV care following HIV self-testing on antiretroviral therapy initiation among adults in Malawi: a randomized clinical trial. JAMA. 2014;312:372-9 pubmed publisher
    ..Self-testing for HIV infection may contribute to early diagnosis of HIV, but without necessarily increasing antiretroviral therapy (ART) initiation...
  51. Anderson S, Cherutich P, Kilonzo N, Cremin I, Fecht D, Kimanga D, et al. Maximising the effect of combination HIV prevention through prioritisation of the people and places in greatest need: a modelling study. Lancet. 2014;384:249-56 pubmed publisher
    ..We hypothesised that focusing appropriate interventions on geographies and key populations at high risk of HIV infection could improve the effect of investments in the HIV response...
  52. Spector L, Murphy S, Wickham K, Lindgren B, Joseph A. Prenatal tobacco exposure and cotinine in newborn dried blood spots. Pediatrics. 2014;133:e1632-8 pubmed publisher
    ..We hypothesize that cotinine in DBS may be a useful measure of newborn in utero tobacco exposure...
  53. Jonas D, Amick H, Feltner C, Bobashev G, Thomas K, Wines R, et al. Pharmacotherapy for adults with alcohol use disorders in outpatient settings: a systematic review and meta-analysis. JAMA. 2014;311:1889-900 pubmed publisher
    ..Alcohol use disorders cause substantial morbidity and early mortality yet remain greatly undertreated. Medications are considerably underused...
  54. Chin R, Fu X, Pai M, Vergnes L, Hwang H, Deng G, et al. The metabolite ?-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR. Nature. 2014;510:397-401 pubmed publisher
  55. Birnbaum M, Mendoza J, Sethi D, Dong S, Glanville J, Dobbins J, et al. Deconstructing the peptide-MHC specificity of T cell recognition. Cell. 2014;157:1073-87 pubmed publisher
    ..The mechanistic basis of TCR cross-reactivity described here enables effective surveillance of diverse self and foreign antigens without necessitating degenerate recognition of nonhomologous peptides. ..
  56. Anguille S, Smits E, Lion E, Van Tendeloo V, Berneman Z. Clinical use of dendritic cells for cancer therapy. Lancet Oncol. 2014;15:e257-67 pubmed publisher
  57. Rapsomaniki E, Timmis A, George J, Pujades Rodriguez M, Shah A, Denaxas S, et al. Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1·25 million people. Lancet. 2014;383:1899-911 pubmed publisher
    ..These findings emphasise the need for new blood pressure-lowering strategies, and will help to inform the design of randomised trials to assess them. Medical Research Council, National Institute for Health Research, and Wellcome Trust. ..
  58. McKenney R, Huynh W, Tanenbaum M, Bhabha G, Vale R. Activation of cytoplasmic dynein motility by dynactin-cargo adapter complexes. Science. 2014;345:337-41 pubmed publisher
    ..Thus, we propose that dynein is largely inactive in the cytoplasm and that a variety of adapter proteins activate processive motility by linking dynactin to dynein only when the motor is bound to its proper cargo. ..
  59. Mente A, O Donnell M, Rangarajan S, McQueen M, Poirier P, Wielgosz A, et al. Association of urinary sodium and potassium excretion with blood pressure. N Engl J Med. 2014;371:601-11 pubmed publisher
    ..Higher levels of sodium intake are reported to be associated with higher blood pressure. Whether this relationship varies according to levels of sodium or potassium intake and in different populations is unknown...
  60. Mozaffarian D, Fahimi S, Singh G, Micha R, Khatibzadeh S, Engell R, et al. Global sodium consumption and death from cardiovascular causes. N Engl J Med. 2014;371:624-34 pubmed publisher
    ..High sodium intake increases blood pressure, a risk factor for cardiovascular disease, but the effects of sodium intake on global cardiovascular mortality are uncertain...
  61. Gordon S, Bruce N, Grigg J, Hibberd P, Kurmi O, Lam K, et al. Respiratory risks from household air pollution in low and middle income countries. Lancet Respir Med. 2014;2:823-60 pubmed publisher
    ..To make clean energy available to all people is the long-term goal, with an intermediate solution being to make available energy that is clean enough to have a health impact. ..
  62. Franceschi C, Campisi J. Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. J Gerontol A Biol Sci Med Sci. 2014;69 Suppl 1:S4-9 pubmed publisher
    ..This article reports the main outcomes of this session. ..
  63. Kris M, Johnson B, Berry L, Kwiatkowski D, Iafrate A, Wistuba I, et al. Using multiplexed assays of oncogenic drivers in lung cancers to select targeted drugs. JAMA. 2014;311:1998-2006 pubmed publisher
    ..The Lung Cancer Mutation Consortium was formed to perform multiplexed assays testing adenocarcinomas of the lung for drivers in 10 genes to enable clinicians to select targeted treatments and enroll patients into clinical trials...
  64. Knowles T, Vendruscolo M, Dobson C. The amyloid state and its association with protein misfolding diseases. Nat Rev Mol Cell Biol. 2014;15:384-96 pubmed publisher
  65. Ussher J, Drucker D. Cardiovascular actions of incretin-based therapies. Circ Res. 2014;114:1788-803 pubmed publisher
    ..Improved understanding of the complex science of incretin-based therapies is required to optimize the selection of these therapeutic agents for the treatment of diabetic patients with cardiovascular disease...
  66. Pagani O, Regan M, Walley B, Fleming G, Colleoni M, Lang I, et al. Adjuvant exemestane with ovarian suppression in premenopausal breast cancer. N Engl J Med. 2014;371:107-18 pubmed publisher
    ..Funded by Pfizer and others; TEXT and SOFT numbers, NCT00066703 and NCT00066690, respectively.). ..
  67. Gilissen C, Hehir Kwa J, Thung D, van de Vorst M, van Bon B, Willemsen M, et al. Genome sequencing identifies major causes of severe intellectual disability. Nature. 2014;511:344-7 pubmed publisher
    ..Genome sequencing can be applied as a single genetic test to reliably identify and characterize the comprehensive spectrum of genetic variation, providing a genetic diagnosis in the majority of patients with severe ID. ..
  68. Bingol B, Tea J, Phu L, Reichelt M, Bakalarski C, Song Q, et al. The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy. Nature. 2014;510:370-5 pubmed publisher
    ..Thus USP30 inhibition is potentially beneficial for Parkinson's disease by promoting mitochondrial clearance and quality control. ..
  69. Wilson M, Naccache S, Samayoa E, Biagtan M, Bashir H, Yu G, et al. Actionable diagnosis of neuroleptospirosis by next-generation sequencing. N Engl J Med. 2014;370:2408-17 pubmed publisher
    ..Polymerase-chain-reaction (PCR) and serologic testing at the Centers for Disease Control and Prevention (CDC) subsequently confirmed evidence of Leptospira santarosai infection. ..
  70. Witte A, Kerti L, Margulies D, Floel A. Effects of resveratrol on memory performance, hippocampal functional connectivity, and glucose metabolism in healthy older adults. J Neurosci. 2014;34:7862-70 pubmed publisher
    ..resveratrol has been shown to increase memory performance in primates; however, interventional studies in older humans are lacking...
  71. Maartens G, Celum C, Lewin S. HIV infection: epidemiology, pathogenesis, treatment, and prevention. Lancet. 2014;384:258-71 pubmed publisher
    ..Research into other prevention interventions, notably vaccines and vaginal microbicides, is in progress...
  72. Chirinos J, Gurubhagavatula I, Teff K, Rader D, Wadden T, Townsend R, et al. CPAP, weight loss, or both for obstructive sleep apnea. N Engl J Med. 2014;370:2265-75 pubmed publisher
    ..Obesity and obstructive sleep apnea tend to coexist and are associated with inflammation, insulin resistance, dyslipidemia, and high blood pressure, but their causal relation to these abnormalities is unclear...
  73. Jørgensen A, Frikke Schmidt R, Nordestgaard B, Tybjærg Hansen A. Loss-of-function mutations in APOC3 and risk of ischemic vascular disease. N Engl J Med. 2014;371:32-41 pubmed publisher
    ..Whether lifelong low levels of nonfasting triglycerides owing to mutations in the gene encoding apolipoprotein C3 (APOC3) are associated with a reduced risk of ischemic cardiovascular disease in the general population is unknown...
  74. Orru C, Bongianni M, Tonoli G, Ferrari S, Hughson A, Groveman B, et al. A test for Creutzfeldt-Jakob disease using nasal brushings. N Engl J Med. 2014;371:519-29 pubmed publisher
    ..We have assessed the accuracy of RT-QuIC analysis of nasal brushings from olfactory epithelium in diagnosing sporadic Creutzfeldt-Jakob disease in living patients...
  75. Heusch G, Libby P, Gersh B, Yellon D, Bohm M, Lopaschuk G, et al. Cardiovascular remodelling in coronary artery disease and heart failure. Lancet. 2014;383:1933-43 pubmed publisher
  76. Kwon E, Drake C, Scher H, Fizazi K, Bossi A, van den Eertwegh A, et al. Ipilimumab versus placebo after radiotherapy in patients with metastatic castration-resistant prostate cancer that had progressed after docetaxel chemotherapy (CA184-043): a multicentre, randomised, double-blind, phase 3 trial. Lancet Oncol. 2014;15:700-12 pubmed publisher
    ..Our aim was to assess the use of ipilimumab after radiotherapy in patients with metastatic castration-resistant prostate cancer that progressed after docetaxel chemotherapy...
  77. Nigro V, Savarese M. Genetic basis of limb-girdle muscular dystrophies: the 2014 update. Acta Myol. 2014;33:1-12 pubmed
  78. van Deursen J. The role of senescent cells in ageing. Nature. 2014;509:439-46 pubmed publisher
  79. Dubois B, Feldman H, Jacova C, Hampel H, Molinuevo J, Blennow K, et al. Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria. Lancet Neurol. 2014;13:614-29 pubmed publisher
    ..This paper also elaborates on the specific diagnostic criteria for atypical forms of AD, for mixed AD, and for the preclinical states of AD. ..
  80. Lawn J, Blencowe H, Oza S, You D, Lee A, Waiswa P, et al. Every Newborn: progress, priorities, and potential beyond survival. Lancet. 2014;384:189-205 pubmed publisher
    ..In the post-2015 era, improvements in child survival, development, and human capital depend on ensuring a healthy start for every newborn baby--the citizens and workforce of the future...
  81. Donath M. Targeting inflammation in the treatment of type 2 diabetes: time to start. Nat Rev Drug Discov. 2014;13:465-76 pubmed publisher
    ..Future immunomodulatory treatments may not target a specific disease, but could instead act on a dysfunctional pathway that causes several conditions associated with the metabolic syndrome...
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