macaca nemestrina

Summary

Summary: A species of the genus MACACA which inhabits Malaya, Sumatra, and Borneo. It is one of the most arboreal species of Macaca. The tail is short and untwisted.

Top Publications

  1. Bonneh Barkay D, Bissel S, Wang G, Fish K, Nicholl G, Darko S, et al. YKL-40, a marker of simian immunodeficiency virus encephalitis, modulates the biological activity of basic fibroblast growth factor. Am J Pathol. 2008;173:130-43 pubmed publisher
  2. Adams Waldorf K, Gravett M, McAdams R, Paolella L, Gough G, Carl D, et al. Choriodecidual group B streptococcal inoculation induces fetal lung injury without intra-amniotic infection and preterm labor in Macaca nemestrina. PLoS ONE. 2011;6:e28972 pubmed publisher
    ..Our objective was to establish a nonhuman primate model of an early stage of chorioamnionitis in order to determine the time course and mechanisms of fetal lung injury in utero...
  3. Chea S, Dale C, De Rose R, Ramshaw I, Kent S. Enhanced cellular immunity in macaques following a novel peptide immunotherapy. J Virol. 2005;79:3748-57 pubmed
    ..De novo hepatitis C virus-specific CD4+- and CD8+-T-cell responses were generated in macaques by the same method. This simple technique holds promise for the immunotherapy of HIV and other chronic viral infections. ..
  4. Bonneh Barkay D, Wang G, Starkey A, Hamilton R, Wiley C. In vivo CHI3L1 (YKL-40) expression in astrocytes in acute and chronic neurological diseases. J Neuroinflammation. 2010;7:34 pubmed publisher
    ..Taken together, these findings demonstrate that CHI3L1 is induced in astrocytes in a variety of neurological diseases but that it is most abundantly associated with astrocytes in regions of inflammatory cells. ..
  5. Flack J, de Waal F, Krakauer D. Social structure, robustness, and policing cost in a cognitively sophisticated species. Am Nat. 2005;165:E126-39 pubmed
    ..Our data and simple model suggest that third-party policing effectiveness and cost are dependent on power structure and might emerge only in societies with high variance in power. ..
  6. O Leary C, Wiseman R, Karl J, Bimber B, Lank S, Tuscher J, et al. Identification of novel MHC class I sequences in pig-tailed macaques by amplicon pyrosequencing and full-length cDNA cloning and sequencing. Immunogenetics. 2009;61:689-701 pubmed publisher
    Pig-tailed macaques (Macaca nemestrina) provide important animal models in biomedical research, but utility of this species for HIV and other disease pathogenesis research is limited by incomplete knowledge of major histocompatibility ..
  7. Dunn F, Doan T, Sampath A, Rieke F. Controlling the gain of rod-mediated signals in the Mammalian retina. J Neurosci. 2006;26:3959-70 pubmed
    ..This work provides physiological insights into the rich history of experiments characterizing how rod vision avoids saturation as light levels increase. ..
  8. Patton D, Cosgrove Sweeney Y, Paul K. A summary of preclinical topical microbicide vaginal safety and chlamydial efficacy evaluations in a pigtailed macaque model. Sex Transm Dis. 2008;35:889-97 pubmed publisher
    ..The macaque preclinical safety and efficacy model is critical to maintaining the pace of topical microbicide development, which could ultimately offer a significant opportunity for intervention in the global HIV/AIDS epidemic. ..
  9. Dale C, De Rose R, Stratov I, Chea S, Montefiori D, Thomson S, et al. Efficacy of DNA and fowlpox virus priming/boosting vaccines for simian/human immunodeficiency virus. J Virol. 2004;78:13819-28 pubmed
    ..These studies suggest that priming of immunity with DNA and fowlpox virus vaccines could delay AIDS in humans...

More Information

Publications82

  1. Smith M, Kohn A. Spatial and temporal scales of neuronal correlation in primary visual cortex. J Neurosci. 2008;28:12591-603 pubmed publisher
    ..These properties and the circuit mechanism they imply provide new constraints on the functional role that correlation may play in visual processing. ..
  2. Lafont B, Buckler White A, Plishka R, Buckler C, Martin M. Pig-tailed macaques (Macaca nemestrina) possess six MHC-E families that are conserved among macaque species: implication for their binding to natural killer receptor variants. Immunogenetics. 2004;56:142-54 pubmed publisher
    ..In this study, we sequenced and analyzed MHC-E alleles of pig-tailed macaque (Macaca nemestrina), a nonhuman primate used for HIV pathogenesis and vaccine studies...
  3. Brennan G, Kozyrev Y, Kodama T, Hu S. Novel TRIM5 isoforms expressed by Macaca nemestrina. J Virol. 2007;81:12210-7 pubmed publisher
    ..Because Macaca nemestrina animals are susceptible to some human immunodeficiency virus (HIV) isolates, we sought to determine if ..
  4. Flack J, Krakauer D. Encoding power in communication networks. Am Nat. 2006;168:E87-102 pubmed
    ..We measure it and study how it arises, using as our model system a pigtailed macaque (Macaca nemestrina) society...
  5. Moritz C, Lucas T, Perlmutter S, Fetz E. Forelimb movements and muscle responses evoked by microstimulation of cervical spinal cord in sedated monkeys. J Neurophysiol. 2007;97:110-20 pubmed
    ..The absence of a clear somatotopic map of output sites is probably a result of the stimulation of complex mixtures of fibers and cells. ..
  6. Kimata J, Wilson J, Patel P. The increased replicative capacity of a late-stage simian immunodeficiency virus mne variant is evident in macrophage- or dendritic cell-T-cell cocultures. Virology. 2004;327:307-17 pubmed
    ..Together, these data suggest that variant viruses that evolve to replicate vigorously in response to APC-T-cell interactions may have increased replicative capacity in vivo. ..
  7. De Rose R, Fernandez C, Smith M, Batten C, Alcantara S, Peut V, et al. Control of viremia and prevention of AIDS following immunotherapy of SIV-infected macaques with peptide-pulsed blood. PLoS Pathog. 2008;4:e1000055 pubmed publisher
    ..Our results suggest Gag alone is an effective antigen for T-cell immunotherapy. Fresh blood cells pulsed with overlapping Gag peptides is proceeding into trials in HIV-infected humans. ..
  8. Lederer S, Favre D, Walters K, Proll S, Kanwar B, Kasakow Z, et al. Transcriptional profiling in pathogenic and non-pathogenic SIV infections reveals significant distinctions in kinetics and tissue compartmentalization. PLoS Pathog. 2009;5:e1000296 pubmed publisher
    ..These patterns provide a unique view of how host responses differ depending upon lentiviral infection outcome. ..
  9. DeDeo S, Krakauer D, Flack J. Inductive game theory and the dynamics of animal conflict. PLoS Comput Biol. 2010;6:e1000782 pubmed publisher
    ..An appreciation of the empirical foundations of the collective dynamics of conflict is a crucial step towards its effective management. ..
  10. Pratt B, O Connor D, Lafont B, Mankowski J, Fernandez C, Triastuti R, et al. MHC class I allele frequencies in pigtail macaques of diverse origin. Immunogenetics. 2006;58:995-1001 pubmed publisher
    Pigtail macaques (Macaca nemestrina) are an increasingly common primate model for the study of human AIDS...
  11. Petravic J, Loh L, Kent S, Davenport M. CD4+ target cell availability determines the dynamics of immune escape and reversion in vivo. J Virol. 2008;82:4091-101 pubmed publisher
    ..This has important implications for comparative studies of immune escape and reversion in different infections and for identifying epitopes with high fitness cost for use as vaccine targets. ..
  12. Li Y, Cleveland B, Klots I, Travis B, Richardson B, Anderson D, et al. Removal of a single N-linked glycan in human immunodeficiency virus type 1 gp120 results in an enhanced ability to induce neutralizing antibody responses. J Virol. 2008;82:638-51 pubmed
    ..These results indicate the potential advantages for glycan modification in vaccine design, although the role of specific glycans requires further examination...
  13. Loh L, Petravic J, Batten C, Davenport M, Kent S. Vaccination and timing influence SIV immune escape viral dynamics in vivo. PLoS Pathog. 2008;4:e12 pubmed publisher
  14. Patton D, Sweeney Y, Cummings P, Meyn L, Rabe L, Hillier S. Safety and efficacy evaluations for vaginal and rectal use of BufferGel in the macaque model. Sex Transm Dis. 2004;31:290-6 pubmed
    ..The nonhuman primate model allows for safety and efficacy testing of topical microbicide products...
  15. Batten C, De Rose R, Wilson K, Agy M, Chea S, Stratov I, et al. Comparative evaluation of simian, simian-human, and human immunodeficiency virus infections in the pigtail macaque (Macaca nemestrina) model. AIDS Res Hum Retroviruses. 2006;22:580-8 pubmed
    ..Pigtail macaques (Macaca nemestrina) are increasingly studied as a nonhuman primate model for AIDS...
  16. Mason R, Alcantara S, Peut V, Loh L, Lifson J, De Rose R, et al. Inactivated simian immunodeficiency virus-pulsed autologous fresh blood cells as an immunotherapy strategy. J Virol. 2009;83:1501-10 pubmed publisher
    ..Future studies of inactivated virus-pulsed blood cell immunotherapy during early infection of patients receiving antiretroviral therapy are warranted...
  17. Alammar L, Gama L, Clements J. Simian immunodeficiency virus infection in the brain and lung leads to differential type I IFN signaling during acute infection. J Immunol. 2011;186:4008-18 pubmed publisher
    ..These data provide a novel observation that during acute SIV infection in the brain, there is differential signaling through the IFN-?/? receptor that fails to activate expression of IFN-? in the brain...
  18. Jackson A, Mavoori J, Fetz E. Correlations between the same motor cortex cells and arm muscles during a trained task, free behavior, and natural sleep in the macaque monkey. J Neurophysiol. 2007;97:360-74 pubmed
    ..These findings extend the interpretation of results obtained under constrained conditions and are relevant to the development of neural prostheses for restoring natural movements to patients with motor deficits...
  19. Jackson A, Mavoori J, Fetz E. Long-term motor cortex plasticity induced by an electronic neural implant. Nature. 2006;444:56-60 pubmed
    ..This method for inducing functional reorganization in vivo by using physiologically derived stimulus trains may have practical application in neurorehabilitation after injury...
  20. Stratov I, Dale C, Chea S, Montefiori D, De Rose R, Reece J, et al. Short communication: characteristics of effective immune control of simian/human immunodeficiency virus in pigtail macaques. AIDS Res Hum Retroviruses. 2006;22:27-32 pubmed
    ..These observations, although in a small subset of animals, suggest the hypothesis that combinations of primed T cell immunity and neutralizing antibodies can maintain control of chronic primate lentiviral infections...
  21. Flack J, De Waal F. Context modulates signal meaning in primate communication. Proc Natl Acad Sci U S A. 2007;104:1581-6 pubmed
    ..show that a special, unidirectional, cost-free dominance-related signal used by monkeys (pigtailed macaques: Macaca nemestrina) means submission (immediate behavior) or subordination (pattern of behavior) depending on the context of ..
  22. Moritz C, Perlmutter S, Fetz E. Direct control of paralysed muscles by cortical neurons. Nature. 2008;456:639-42 pubmed publisher
    ..Here we show that Macaca nemestrina monkeys can directly control stimulation of muscles using the activity of neurons in the motor cortex, ..
  23. Beard B, Dickerson D, Beebe K, Gooch C, Fletcher J, Okbinoglu T, et al. Comparison of HIV-derived lentiviral and MLV-based gammaretroviral vector integration sites in primate repopulating cells. Mol Ther. 2007;15:1356-65 pubmed
    ..These data help define the relative risk of insertional mutagenesis with MLV-, HIV-, and simian immunodeficiency virus (SIV)-based vectors in a highly relevant primate model...
  24. Fernandez C, Reece J, Saepuloh U, De Rose R, Ishkandriati D, O Connor D, et al. Screening and confirmatory testing of MHC class I alleles in pig-tailed macaques. Immunogenetics. 2011;63:511-21 pubmed publisher
    Pig-tailed macaques (Macaca nemestrina) are a commonly studied primate model of human AIDS. The Mane-A1*084:01 MHC class I allele (previously named Mane-A*10) is important for the control of SIV infection by CD8+ T cells in this model...
  25. Favre D, Lederer S, Kanwar B, Ma Z, Proll S, Kasakow Z, et al. Critical loss of the balance between Th17 and T regulatory cell populations in pathogenic SIV infection. PLoS Pathog. 2009;5:e1000295 pubmed publisher
    ..The loss of Th17 cells was found to be predictive of systemic and sustained T cell activation. Collectively, these data indicate that loss of the Th17 to Treg balance is related to SIV disease progression...
  26. Umilta M, Escola L, Intskirveli I, Grammont F, Rochat M, Caruana F, et al. When pliers become fingers in the monkey motor system. Proc Natl Acad Sci U S A. 2008;105:2209-13 pubmed publisher
    ..We conclude that the capacity to use tools is based on an inherently goal-centered functional organization of primate cortical motor areas...
  27. Loh L, Reece J, Fernandez C, Alcantara S, Center R, Howard J, et al. Complexity of the inoculum determines the rate of reversion of SIV Gag CD8 T cell mutant virus and outcome of infection. PLoS Pathog. 2009;5:e1000378 pubmed publisher
    ..The delay in reversion of fitness-reducing CD8 T cell escape mutations in some scenarios suggests opportunities to reduce the pathogenicity of HIV during very early infection...
  28. Mavoori J, Jackson A, Diorio C, Fetz E. An autonomous implantable computer for neural recording and stimulation in unrestrained primates. J Neurosci Methods. 2005;148:71-7 pubmed
    ..After downloading the parameters for recording, stimulation, discrimination, and other computations, the device is capable of operating autonomously, delivering stimuli to one electrode triggered by spikes recorded at a separate site...
  29. Ferrari P, Rozzi S, Fogassi L. Mirror neurons responding to observation of actions made with tools in monkey ventral premotor cortex. J Cogn Neurosci. 2005;17:212-26 pubmed
    ..Our findings support the notion that the motor cortex plays a crucial role in understanding action goals...
  30. Biesinger T, Yu Kimata M, Kimata J. Changes in simian immunodeficiency virus reverse transcriptase alleles that appear during infection of macaques enhance infectivity and replication in CD4+ T cells. Virology. 2008;370:184-93 pubmed
    ..Taken together, our data underscore the importance of RT determinants for pathogenicity of SIV and for the capacity to replicate in CD4(+) T cell populations...
  31. Chang J, Jain S, Carl D, Paolella L, Darveau R, Gravett M, et al. Differential host response to LPS variants in amniochorion and the TLR4/MD-2 system in Macaca nemestrina. Placenta. 2010;31:811-7 pubmed publisher
    ..We also cloned Macaca nemestrina TLR4 and MD-2 and compared this complex functionally to the human homologue to establish whether nonhuman ..
  32. De Rose R, Batten C, Smith M, Fernandez C, Peut V, Thomson S, et al. Comparative efficacy of subtype AE simian-human immunodeficiency virus priming and boosting vaccines in pigtail macaques. J Virol. 2007;81:292-300 pubmed
    ..These studies suggest priming of T-cell immunity to prevent AIDS in humans is possible, but differences in the immunogenicity of various subtype vaccines and broad cross-subtype protection are substantial hurdles...
  33. Barber S, Gama L, Li M, Voelker T, Anderson J, Zink M, et al. Longitudinal analysis of simian immunodeficiency virus (SIV) replication in the lungs: compartmentalized regulation of SIV. J Infect Dis. 2006;194:931-8 pubmed
    ..In the present study, we examine virus replication in the lungs and in cells recovered from bronchoalveolar lavage (BAL) samples in a comprehensive, longitudinal analysis of an SIV/macaque model...
  34. Berger C, Berger M, Anderson D, Riddell S. A non-human primate model for analysis of safety, persistence, and function of adoptively transferred T cells. J Med Primatol. 2011;40:88-103 pubmed publisher
    Adoptive immunotherapy with antigen-specific effector T-cell (T(E) ) clones is often limited by poor survival of the transferred cells. We describe here a Macaca nemestrina model for studying transfer of T-cell immunity.
  35. Klatt N, Harris L, Vinton C, Sung H, Briant J, Tabb B, et al. Compromised gastrointestinal integrity in pigtail macaques is associated with increased microbial translocation, immune activation, and IL-17 production in the absence of SIV infection. Mucosal Immunol. 2010;3:387-98 pubmed publisher
    ..Furthermore, these data suggest that PTM may be an ideal model to study therapeutic interventions aimed at decreasing microbial translocation-induced immune activation. ..
  36. Venneti S, Bonneh Barkay D, Lopresti B, Bissel S, Wang G, Mathis C, et al. Longitudinal in vivo positron emission tomography imaging of infected and activated brain macrophages in a macaque model of human immunodeficiency virus encephalitis correlates with central and peripheral markers of encephalitis and areas of synaptic. Am J Pathol. 2008;172:1603-16 pubmed publisher
    ..A combination of PET imaging and the assessment of these peripheral immune parameters may facilitate longitudinal assessment of lentiviral encephalitis in living patients as well as evaluation of therapeutic efficacies...
  37. Westerman L, McClure H, Jiang B, Almond J, Glass R. Serum IgG mediates mucosal immunity against rotavirus infection. Proc Natl Acad Sci U S A. 2005;102:7268-73 pubmed
    ..The observation that passively transferred antibodies can suppress or delay viral infection in rotavirus-challenged pigtailed macaques has important implications for the design and testing of parenteral candidate rotavirus vaccines...
  38. Fernandez C, Stratov I, De Rose R, Walsh K, Dale C, Smith M, et al. Rapid viral escape at an immunodominant simian-human immunodeficiency virus cytotoxic T-lymphocyte epitope exacts a dramatic fitness cost. J Virol. 2005;79:5721-31 pubmed
    ..Quantifying both the selection pressure exerted by CTL and the fitness costs of escape mutation has important implications for the development of CTL-based vaccine strategies...
  39. Churchland M, Yu B, Cunningham J, Sugrue L, Cohen M, Corrado G, et al. Stimulus onset quenches neural variability: a widespread cortical phenomenon. Nat Neurosci. 2010;13:369-78 pubmed publisher
    ..This widespread variability decline suggests a rather general property of cortex, that its state is stabilized by an input...
  40. Mason R, De Rose R, Kent S. Differential patterns of immune escape at Tat-specific cytotoxic T cell epitopes in pigtail macaques. Virology. 2009;388:315-23 pubmed publisher
    ..Our results suggest that some regulatory or accessory CTL epitopes may be useful targets for vaccination against HIV...
  41. Bissel S, Wang G, Bonneh Barkay D, Starkey A, Trichel A, Murphey Corb M, et al. Systemic and brain macrophage infections in relation to the development of simian immunodeficiency virus encephalitis. J Virol. 2008;82:5031-42 pubmed publisher
    ..These findings support the hypothesis that inherent differences in host systemic and CNS monocyte/macrophage viral production are associated with the development of encephalitis...
  42. Rigamonti M, Custance D, Previde E, Spiezio C. Testing for localized stimulus enhancement and object movement reenactment in pig-tailed macaques (Macaca nemestrina) and young children (Homo sapiens). J Comp Psychol. 2005;119:257-72 pubmed
    ..investigate localized stimulus enhancement and object movement reenactment (OMR) in 13 pig-tailed macaques (Macaca nemestrina) and 30 human infants (Homo sapiens). Participants received contrasting demonstrations on each box...
  43. Hukkanen R, Liggitt H, Anderson D, Kelley S. Detection of systemic amyloidosis in the pig-tailed macaque (Macaca nemestrina). Comp Med. 2006;56:119-27 pubmed
    ..In an attempt to elucidate an antemortem diagnosis, 30 female pig-tailed macaques (Macaca nemestrina) at the Washington National Primate Research Center were surveyed for amyloidosis...
  44. Loh L, Batten C, Petravic J, Davenport M, Kent S. In vivo fitness costs of different Gag CD8 T-cell escape mutant simian-human immunodeficiency viruses for macaques. J Virol. 2007;81:5418-22 pubmed
    ..The fitness impact of these mutations is KP9 > AF9 > KW9. These data provide insights into the differential utility of CTL in controlling viremia...
  45. Kim C, Adams D, Bashirian S, Butera S, Folks T, Otten R. Repetitive exposures with simian/human immunodeficiency viruses: strategy to study HIV pre-clinical interventions in non-human primates. J Med Primatol. 2006;35:210-6 pubmed
    ..Therefore, we have developed a repetitive mucosal exposure model using doses of virus that better reflects human exposures...
  46. Polacino P, Larsen K, Galmin L, Suschak J, Kraft Z, Stamatatos L, et al. Differential pathogenicity of SHIV infection in pig-tailed and rhesus macaques. J Med Primatol. 2008;37 Suppl 2:13-23 pubmed publisher
    ..However, little is known about the comparative susceptibility of pig-tailed macaques to lentivirus infection and diseases...
  47. Parikh U, Dobard C, Sharma S, Cong M, Jia H, Martin A, et al. Complete protection from repeated vaginal simian-human immunodeficiency virus exposures in macaques by a topical gel containing tenofovir alone or with emtricitabine. J Virol. 2009;83:10358-65 pubmed publisher
    ..Thus, single drugs with durable antiviral activity can provide highly effective topical prophylaxis and overcome the need for noncoital use or for drug combinations which are more complex and costly to formulate and approve...
  48. Zink M, Uhrlaub J, DeWitt J, Voelker T, Bullock B, Mankowski J, et al. Neuroprotective and anti-human immunodeficiency virus activity of minocycline. JAMA. 2005;293:2003-11 pubmed
    ..Current antiretroviral drugs are expensive, have significant adverse effects including neurotoxicity, and few cross the blood-brain barrier...
  49. Trobridge G, Beard B, Gooch C, Wohlfahrt M, Olsen P, Fletcher J, et al. Efficient transduction of pigtailed macaque hematopoietic repopulating cells with HIV-based lentiviral vectors. Blood. 2008;111:5537-43 pubmed publisher
    ..We have established conditions for efficient transduction of pigtailed macaque (Macaca nemestrina) long-term repopulating cells using VSV-G-pseudotyped HIV-based lentiviral vectors...
  50. Kent S, De Rose R, Mokhonov V, Mokhonova E, Fernandez C, Alcantara S, et al. Evaluation of recombinant Kunjin replicon SIV vaccines for protective efficacy in macaques. Virology. 2008;374:528-34 pubmed publisher
    ..Refinements of this vector system and optimization of the immunization doses, routes, and schedules are required prior to clinical trials...
  51. Vishwanathan S, Guenthner P, Lin C, Dobard C, Sharma S, Adams D, et al. High susceptibility to repeated, low-dose, vaginal SHIV exposure late in the luteal phase of the menstrual cycle of pigtail macaques. J Acquir Immune Defic Syndr. 2011;57:261-4 pubmed publisher
    ..Our data support the findings of higher susceptibility to HIV in women during progesterone-dominated periods including pregnancy and contraceptive use...
  52. Smith M, Fernandez C, Chung A, Dale C, De Rose R, Lin J, et al. The pigtail macaque MHC class I allele Mane-A*10 presents an immundominant SIV Gag epitope: identification, tetramer development and implications of immune escape and reversion. J Med Primatol. 2005;34:282-93 pubmed
    The pigtail macaque (Macaca nemestrina) is a common model for the study of AIDS...
  53. Raos V, Umiltà M, Murata A, Fogassi L, Gallese V. Functional properties of grasping-related neurons in the ventral premotor area F5 of the macaque monkey. J Neurophysiol. 2006;95:709-29 pubmed
  54. Patton D, Sweeney Y, Tsai C, Hillier S. Macaca fascicularis vs. Macaca nemestrina as a model for topical microbicide safety studies. J Med Primatol. 2004;33:105-8 pubmed
    ..The pig-tailed macaque (Macaca nemestrina) model has been used to assess the safety of vaginally and rectally applied topical microbicide products...
  55. McAdams R, Vanderhoeven J, Beyer R, Bammler T, Farin F, Liggitt H, et al. Choriodecidual infection downregulates angiogenesis and morphogenesis pathways in fetal lungs from Macaca nemestrina. PLoS ONE. 2012;7:e46863 pubmed publisher
    ..We evaluated the effects of GBS exposure on RNA expression in fetal lung tissue to determine early molecular pathways associated with fetal lung injury that may progress to BPD...
  56. Alcantara S, Reece J, Amarasena T, Rose R, Manitta J, Amin J, et al. Thrombocytopenia is strongly associated with simian AIDS in pigtail macaques. J Acquir Immune Defic Syndr. 2009;51:374-9 pubmed publisher
    ..We commonly observed thrombocytopenia (TCP) associated with progressive SIV infection of pigtail macaques (Macaca nemestrina)...
  57. Kent S, Dale C, Ranasinghe C, Stratov I, De Rose R, Chea S, et al. Mucosally-administered human-simian immunodeficiency virus DNA and fowlpoxvirus-based recombinant vaccines reduce acute phase viral replication in macaques following vaginal challenge with CCR5-tropic SHIVSF162P3. Vaccine. 2005;23:5009-21 pubmed
    ..Our data suggest strategies for effective priming of partial immunity to mucosal HIV-1 exposure utilizing systemic prime and mucosal boost vaccination strategies...
  58. Babas T, DeWitt J, Mankowski J, Tarwater P, Clements J, Zink M. Progressive selection for neurovirulent genotypes in the brain of SIV-infected macaques. AIDS. 2006;20:197-205 pubmed
    ..To compare the viral genotypes present in RNA from brain and peripheral blood mononuclear cells (PBMC) and DNA from brain during acute, asymptomatic and late stages of SIV infection of macaques...
  59. Ho O, Larsen K, Polacino P, Li Y, Anderson D, Song R, et al. Pathogenic infection of Macaca nemestrina with a CCR5-tropic subtype-C simian-human immunodeficiency virus. Retrovirology. 2009;6:65 pubmed publisher
    Although pig-tailed macaques (Macaca nemestrina) have been used in AIDS research for years, less is known about the early immunopathogenic events in this species, as compared to rhesus macaques (Macaca mulatta)...
  60. Stratov I, Dale C, Chea S, McCluskey J, Kent S. Induction of T-cell immunity to antiretroviral drug-resistant human immunodeficiency virus type 1. J Virol. 2005;79:7728-37 pubmed
    ..This study suggests feasible strategies to further evaluate the potential of limiting antiretroviral drug resistance through induction of T-cell immunity...
  61. Brennan G, Kozyrev Y, Hu S. TRIMCyp expression in Old World primates Macaca nemestrina and Macaca fascicularis. Proc Natl Acad Sci U S A. 2008;105:3569-74 pubmed publisher
    ..b>Macaca nemestrina do not express TRIM5alpha; therefore, we asked whether these animals and related Old World primates express ..
  62. Berger C, Jensen M, Lansdorp P, Gough M, Elliott C, Riddell S. Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates. J Clin Invest. 2008;118:294-305 pubmed
    ..These results could have significant implications for the selection of T cells to expand or to engineer for adoptive immunotherapy of human infections or malignancy...
  63. Fernandez C, Smith M, Batten C, De Rose R, Reece J, Rollman E, et al. Vaccine-induced T cells control reversion of AIDS virus immune escape mutants. J Virol. 2007;81:4137-44 pubmed
    ..These findings have important implications for the further development of T-cell-based HIV vaccines where exposure to escape mutant viruses is common...
  64. Humes D, Overbaugh J. Adaptation of subtype a human immunodeficiency virus type 1 envelope to pig-tailed macaque cells. J Virol. 2011;85:4409-20 pubmed publisher
    ..These findings identify the inefficient use of Ptm CD4 as an unappreciated restriction to subtype A HIV-1 replication in Ptm cells and reveal amino acid changes to gp120 that can overcome this barrier...
  65. Jayaraman P, Mohan D, Polacino P, Kuller L, Sheikh N, Bielefeldt Ohmann H, et al. Perinatal transmission of SHIV-SF162P3 in Macaca nemestrina. J Med Primatol. 2004;33:243-50 pubmed
    ..This transmission model can allow investigation of key parameters involved in perinatal transmission of HIV...
  66. Zanos S, Richardson A, Shupe L, Miles F, Fetz E. The Neurochip-2: an autonomous head-fixed computer for recording and stimulating in freely behaving monkeys. IEEE Trans Neural Syst Rehabil Eng. 2011;19:427-35 pubmed publisher
    ..The Neurochip-2 can record and stimulate autonomously for up to several days in freely behaving monkeys, enabling a wide range of novel neurophysiological and neuroengineering experiments...
  67. Barber S, Gama L, Dudaronek J, Voelker T, Tarwater P, Clements J. Mechanism for the establishment of transcriptional HIV latency in the brain in a simian immunodeficiency virus-macaque model. J Infect Dis. 2006;193:963-70 pubmed
    ..The brain is considered to be a reservoir of latent human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV). We examined the mechanism by which innate immune responses contribute to the establishment of this reservoir...
  68. Biesinger T, White R, Yu Kimata M, Wilson B, Allan J, Kimata J. Relative replication capacity of phenotypic SIV variants during primary infections differs with route of inoculation. Retrovirology. 2010;7:88 pubmed publisher
  69. Polacino P, Cleveland B, Zhu Y, Kimata J, Overbaugh J, Anderson D, et al. Immunogenicity and protective efficacy of Gag/Pol/Env vaccines derived from temporal isolates of SIVmne against cognate virus challenge. J Med Primatol. 2007;36:254-65 pubmed
    ..SIVmne170 is a molecular clone isolated from a pig-tailed macaque 170 weeks after inoculation with SIVmneCL8...
  70. Loh L, Kent S. Quantification of simian immunodeficiency virus cytotoxic T lymphocyte escape mutant viruses. AIDS Res Hum Retroviruses. 2008;24:1067-72 pubmed publisher
    ..These data help refine our understanding of how CTL escape mutant viruses evolve...
  71. Sexton A, De Rose R, Reece J, Alcantara S, Loh L, Moffat J, et al. Evaluation of recombinant influenza virus-simian immunodeficiency virus vaccines in macaques. J Virol. 2009;83:7619-28 pubmed publisher
    ..Although our results suggest that influenza virus-HIV vaccines hold promise for the induction of mucosal immunity to HIV, broader antigen cover will be needed to limit cytotoxic T-lymphocyte escape...
  72. De Rose R, Mason R, Loh L, Peut V, Smith M, Fernandez C, et al. Safety, immunogenicity and efficacy of peptide-pulsed cellular immunotherapy in macaques. J Med Primatol. 2008;37 Suppl 2:69-78 pubmed publisher
    ..We recently published on the effectiveness of using ex vivo pulsing of overlapping SIV Gag 15mer peptides onto fresh peripheral blood cells in 32 SIV(mac251)-infected pigtail macaques...
  73. Smith M, Dale C, De Rose R, Stratov I, Fernandez C, Brooks A, et al. Analysis of pigtail macaque major histocompatibility complex class I molecules presenting immunodominant simian immunodeficiency virus epitopes. J Virol. 2005;79:684-95 pubmed
    ..responses and their restricting major histocompatibility complex (MHC) class I alleles in pigtail macaques (Macaca nemestrina), an increasingly common primate model for the study of HIV infection of humans...