macaca mulatta

Summary

Summary: A species of the genus MACACA inhabiting India, China, and other parts of Asia. The species is used extensively in biomedical research and adapts very well to living with humans.

Top Publications

  1. Song H, Janosko K, Johnson R, Qin J, Josleyn N, Jett C, et al. Poxvirus antigen staining of immune cells as a biomarker to predict disease outcome in monkeypox and cowpox virus infection in non-human primates. PLoS ONE. 2013;8:e60533 pubmed publisher
    ..Future studies should focus on the mechanisms and implications of the pox-infection of immune cells and the correlation between pox-antigen detection in immune cells and disease progression in human poxviral infection...
  2. Zhao C, Xue J, Cong Z, Gao X, Zhang W, Chen T, et al. Circulating IL-21 levels increase during early simian-human immunodeficiency virus infection in macaques. Arch Virol. 2013;158:853-8 pubmed publisher
    ..We conclude that IL-21 has a likely role in the immunopathogenesis of HIV/SIV/SHIV. ..
  3. Suzuki M, Gottlieb J. Distinct neural mechanisms of distractor suppression in the frontal and parietal lobe. Nat Neurosci. 2013;16:98-104 pubmed publisher
    ..Although both areas can contribute to the perceptual selection of salient information, the dlPFC has a decisive influence on whether and how attended stimulus is linked with actions. ..
  4. Bachler B, Humbert M, Palikuqi B, Siddappa N, Lakhashe S, Rasmussen R, et al. Novel biopanning strategy to identify epitopes associated with vaccine protection. J Virol. 2013;87:4403-16 pubmed publisher
    ..PL biopanning is also unbiased with regard to pathogens or disease model, making it a universal tool...
  5. Buschman T, Denovellis E, Diogo C, Bullock D, Miller E. Synchronous oscillatory neural ensembles for rules in the prefrontal cortex. Neuron. 2012;76:838-846 pubmed publisher
    ..Synchrony may act to dynamically shape task-relevant neural ensembles out of larger, overlapping circuits...
  6. Mante V, Sussillo D, Shenoy K, Newsome W. Context-dependent computation by recurrent dynamics in prefrontal cortex. Nature. 2013;503:78-84 pubmed publisher
  7. Ohkura S, Stoye J. A comparison of murine leukemia viruses that escape from human and rhesus macaque TRIM5?s. J Virol. 2013;87:6455-68 pubmed publisher
  8. Virnik K, Ni Y, Berkower I. Enhanced expression of HIV and SIV vaccine antigens in the structural gene region of live attenuated rubella viral vectors and their incorporation into virions. Vaccine. 2013;31:2119-25 pubmed publisher
    ..The rubella vaccine strain readily infects rhesus macaques, and these animals will be the model of choice for testing vector growth in vivo and immunogenicity...
  9. Haanstra K, Hofman S, Lopes Estêvão D, Blezer E, Bauer J, Yang L, et al. Antagonizing the ?4?1 integrin, but not ?4?7, inhibits leukocytic infiltration of the central nervous system in rhesus monkey experimental autoimmune encephalomyelitis. J Immunol. 2013;190:1961-73 pubmed publisher
    ..These results demonstrate that blocking ?(4)?(7) exclusively does not inhibit immune surveillance of the CNS in primates...

More Information

Publications65

  1. Morton F, Lee P, Buchanan Smith H, Brosnan S, Thierry B, Paukner A, et al. Personality structure in brown capuchin monkeys (Sapajus apella): comparisons with chimpanzees (Pan troglodytes), orangutans (Pongo spp.), and rhesus macaques (Macaca mulatta). J Comp Psychol. 2013;127:282-98 pubmed publisher
    ..and rhesus macaques (Macaca mulatta)...
  2. Watson K, Platt M. Social signals in primate orbitofrontal cortex. Curr Biol. 2012;22:2268-73 pubmed publisher
    ..Our results betray a fundamental disconnect between preferences expressed through overt choice, which were primarily driven by the desire for more fluid, and preferential neuronal processing, which favored social computations. ..
  3. Yingst S, Facemire P, Chuvala L, Norwood D, Wolcott M, Alves D. Pathological findings and diagnostic implications of a rhesus macaque (Macaca mulatta) model of aerosol-exposure melioidosis (Burkholderia pseudomallei). J Med Microbiol. 2014;63:118-28 pubmed publisher
  4. Choudhary A, Galvin T, Williams D, BEREN J, Bryant M, Khan A. Influence of naturally occurring simian foamy viruses (SFVs) on SIV disease progression in the rhesus macaque (Macaca mulatta) model. Viruses. 2013;5:1414-30 pubmed publisher
  5. Mudd P, Martins M, Ericsen A, Tully D, Power K, Bean A, et al. Vaccine-induced CD8+ T cells control AIDS virus replication. Nature. 2012;491:129-33 pubmed publisher
    ..Our findings indicate that narrowly targeted vaccine-induced virus-specific CD8(+) T-cell responses can control replication of the AIDS virus...
  6. Hawrylycz M, Lein E, Guillozet Bongaarts A, Shen E, Ng L, Miller J, et al. An anatomically comprehensive atlas of the adult human brain transcriptome. Nature. 2012;489:391-399 pubmed publisher
    ..This freely accessible online data resource forms a high-resolution transcriptional baseline for neurogenetic studies of normal and abnormal human brain function. ..
  7. Francella N, Gwyn S, Yi Y, Li B, Xiao P, Elliott S, et al. CD4+ T cells support production of simian immunodeficiency virus Env antibodies that enforce CD4-dependent entry and shape tropism in vivo. J Virol. 2013;87:9719-32 pubmed publisher
    ..In the absence of this constraint and with a relative paucity of CD4(+) target cells, widespread macrophage infection occurs in vivo accompanied by emergence of variants carrying structural changes that enable entry independently of CD4...
  8. Meyer C, Dewane J, Kerns A, Haberthur K, Barron A, Park B, et al. Age and immune status of rhesus macaques impact simian varicella virus gene expression in sensory ganglia. J Virol. 2013;87:8294-306 pubmed publisher
    ..Therefore, immune fitness at the time of infection modulates the establishment and/or maintenance of SVV latency. ..
  9. Shokur S, O Doherty J, Winans J, Bleuler H, Lebedev M, Nicolelis M. Expanding the primate body schema in sensorimotor cortex by virtual touches of an avatar. Proc Natl Acad Sci U S A. 2013;110:15121-6 pubmed publisher
    ..We propose that S1 and M1 contribute to the rubber hand illusion and that, by taking advantage of plasticity in these areas, patients may assimilate neuroprosthetic limbs as parts of their body schema. ..
  10. Borton D, Yin M, Aceros J, Nurmikko A. An implantable wireless neural interface for recording cortical circuit dynamics in moving primates. J Neural Eng. 2013;10:026010 pubmed publisher
    ..Such systems must be chronically safe, durable and effective...
  11. Honing H, Merchant H, Háden G, Prado L, Bartolo R. Rhesus monkeys (Macaca mulatta) detect rhythmic groups in music, but not the beat. PLoS ONE. 2012;7:e51369 pubmed publisher
    ..To test this hypothesis we measured auditory event-related potentials (ERPs) in two rhesus monkeys (Macaca mulatta), probing a well-documented component in humans, the mismatch negativity (MMN) to study rhythmic expectation...
  12. Fiorillo C, Yun S, Song M. Diversity and homogeneity in responses of midbrain dopamine neurons. J Neurosci. 2013;33:4693-709 pubmed publisher
    ..In conclusion, we find a diversity of response properties, distributed along a continuum, within what may be a single functional population of neurons signaling reward prediction error...
  13. Uslaner J, Tye S, Eddins D, Wang X, Fox S, Savitz A, et al. Orexin receptor antagonists differ from standard sleep drugs by promoting sleep at doses that do not disrupt cognition. Sci Transl Med. 2013;5:179ra44 pubmed publisher
    ..These findings suggest that DORAs might provide an effective treatment for insomnia with a greater therapeutic margin for sleep versus cognitive disturbances compared to the GABAA-positive allosteric modulators currently in use...
  14. Renner N, Sansing H, Inglis F, Mehra S, Kaushal D, Lackner A, et al. Transient acidification and subsequent proinflammatory cytokine stimulation of astrocytes induce distinct activation phenotypes. J Cell Physiol. 2013;228:1284-94 pubmed publisher
    ..These results suggest that astrocytes are capable of multiple phenotypes depending on the stimulus and the order stimuli are applied...
  15. Hong J, Amancha P, Rogers K, Ansari A, Villinger F. Re-evaluation of PD-1 expression by T cells as a marker for immune exhaustion during SIV infection. PLoS ONE. 2013;8:e60186 pubmed publisher
  16. Hansen B, Chelaru M, Dragoi V. Correlated variability in laminar cortical circuits. Neuron. 2012;76:590-602 pubmed publisher
    ..Contrary to expectation that the output cortical layers encode stimulus information most accurately, we found that the input network offers superior discrimination performance compared to the output networks...
  17. Jones H, Andolina I, Ahmed B, Shipp S, Clements J, Grieve K, et al. Differential feedback modulation of center and surround mechanisms in parvocellular cells in the visual thalamus. J Neurosci. 2012;32:15946-51 pubmed publisher
    ..In short, both center and surround mechanisms are influenced by the feedback. This dynamically sharpens the spatial focus of the receptive field and introduces nonlinearities from the cortical mechanism into the LGN...
  18. Nunamaker E, Halliday L, Moody D, Fang W, Lindeblad M, Fortman J. Pharmacokinetics of 2 formulations of buprenorphine in macaques (Macaca mulatta and Macaca fascicularis). J Am Assoc Lab Anim Sci. 2013;52:48-56 pubmed
  19. Kaliukhovich D, De Baene W, Vogels R. Effect of adaptation on object representation accuracy in macaque inferior temporal cortex. J Cogn Neurosci. 2013;25:777-89 pubmed publisher
    ..These findings suggest that short-term, stimulus-specific adaptation in IT supports efficient coding of stimuli that differ from recently seen ones while impairing the coding of repeated stimuli...
  20. Wang M, Yang Y, Wang C, Gamo N, Jin L, Mazer J, et al. NMDA receptors subserve persistent neuronal firing during working memory in dorsolateral prefrontal cortex. Neuron. 2013;77:736-49 pubmed publisher
    ..The reliance of Delay cells on NMDAR may explain why insults to NMDARs in schizophrenia or Alzheimer's disease profoundly impair cognition...
  21. Nassi J, Lomber S, Born R. Corticocortical feedback contributes to surround suppression in V1 of the alert primate. J Neurosci. 2013;33:8504-17 pubmed publisher
    ..Our results provide direct evidence that feedback contributes to surround suppression, which is an important source of contextual influences essential to vision...
  22. Stokes M, Kusunoki M, Sigala N, Nili H, Gaffan D, Duncan J. Dynamic coding for cognitive control in prefrontal cortex. Neuron. 2013;78:364-75 pubmed publisher
    ..These results demonstrate how neural tuning profiles in prefrontal cortex adapt to accommodate changes in behavioral context. Highly flexible tuning could be mediated via short-term synaptic plasticity...
  23. Jalah R, Rosati M, Ganneru B, Pilkington G, Valentin A, Kulkarni V, et al. The p40 subunit of interleukin (IL)-12 promotes stabilization and export of the p35 subunit: implications for improved IL-12 cytokine production. J Biol Chem. 2013;288:6763-76 pubmed publisher
    ..Therefore, the improved IL-12p70 DNA vectors have promising potential for in vivo use as molecular vaccine adjuvants and in cancer immunotherapy...
  24. Nie K, Ling L, Bierer S, Kaneko C, Fuchs A, Oxford T, et al. An experimental vestibular neural prosthesis: design and preliminary results with rhesus monkeys stimulated with modulated pulses. IEEE Trans Biomed Eng. 2013;60:1685-92 pubmed publisher
    ..Both PAM and PRM pulse trains can elicit a significant amount of in-phase modulated eye velocity changes and they could potentially be used for efficiently coding head rotational signals in future vestibular neural prostheses...
  25. Jaworski J, Kobie J, Brower Z, Malherbe D, Landucci G, Sutton W, et al. Neutralizing polyclonal IgG present during acute infection prevents rapid disease onset in simian-human immunodeficiency virus SHIVSF162P3-infected infant rhesus macaques. J Virol. 2013;87:10447-59 pubmed publisher
  26. Li D, XU H, Trask J, Zhu Q, Cheng A, Smith D, et al. Genetic diversity and population structure in wild Sichuan rhesus macaques. Mol Biol Rep. 2013;40:3033-41 pubmed publisher
    Because wild rhesus macaque (Macaca mulatta) populations have suffered major declines, there is a growing need to characterize their genetic and population structure in order to protect the genetic integrity of this species...
  27. Satkoski Trask J, Garnica W, Smith D, Houghton P, Lerche N, Kanthaswamy S. Single-nucleotide polymorphisms reveal patterns of allele sharing across the species boundary between rhesus (Macaca mulatta) and cynomolgus (M. fascicularis) macaques. Am J Primatol. 2013;75:135-44 pubmed publisher
    Both phenotypic and genetic evidence for asymmetric hybridization between rhesus (Macaca mulatta) and cynomolgus (Macaca fascicularis) macaques has been observed in the region of Indochina where both species are sympatric...
  28. Patel V, Jalah R, Kulkarni V, Valentin A, Rosati M, Alicea C, et al. DNA and virus particle vaccination protects against acquisition and confers control of viremia upon heterologous simian immunodeficiency virus challenge. Proc Natl Acad Sci U S A. 2013;110:2975-80 pubmed publisher
    ..These studies support a role of DNA and protein-based vaccines for development of an efficacious HIV/AIDS vaccine...
  29. Moldt B, Rakasz E, Schultz N, Chan Hui P, Swiderek K, Weisgrau K, et al. Highly potent HIV-specific antibody neutralization in vitro translates into effective protection against mucosal SHIV challenge in vivo. Proc Natl Acad Sci U S A. 2012;109:18921-5 pubmed publisher
  30. Spear G, Rothaeulser K, Fritts L, Gillevet P, Miller C. In captive rhesus macaques, cervicovaginal inflammation is common but not associated with the stable polymicrobial microbiome. PLoS ONE. 2012;7:e52992 pubmed publisher
    ..It seems likely that results of published vaginal SIV transmission experiments in RM have been influenced by pre-existing inflammation in the animals used for the experiments...
  31. Liu Y, Li A, Wang X, Sui L, Li M, Zhao Y, et al. Mamu-B genes and their allelic repertoires in different populations of Chinese-origin rhesus macaques. Immunogenetics. 2013;65:273-80 pubmed publisher
    ..Our results are an important addition to the limited MHC immunogenetic information available for rhesus macaques of Chinese origin...
  32. Tabb B, Morcock D, Trubey C, Quiñones O, Hao X, Smedley J, et al. Reduced inflammation and lymphoid tissue immunopathology in rhesus macaques receiving anti-tumor necrosis factor treatment during primary simian immunodeficiency virus infection. J Infect Dis. 2013;207:880-92 pubmed publisher
  33. Lopker M, Easlick J, Sterrett S, Decker J, Barbian H, Learn G, et al. Heterogeneity in neutralization sensitivities of viruses comprising the simian immunodeficiency virus SIVsmE660 isolate and vaccine challenge stock. J Virol. 2013;87:5477-92 pubmed publisher
    ..These findings may explain the variable natural history and variable protection afforded by heterologous Env-based vaccines in rhesus macaques challenged by high-dose versus low-dose SIVsmE660 inoculation regimens...
  34. Mackevicius E, Best M, Saal H, BensmaIa S. Millisecond precision spike timing shapes tactile perception. J Neurosci. 2012;32:15309-17 pubmed publisher
    ..In light of these results, the peripheral representation of complex skin vibrations draws a powerful analogy with the auditory and vibrissal systems...
  35. Mumbauer A, Gettie A, Blanchard J, Cheng Mayer C. Efficient mucosal transmissibility but limited pathogenicity of R5 SHIV SF162P3N in Chinese-origin rhesus macaques. J Acquir Immune Defic Syndr. 2013;62:496-504 pubmed publisher
    ..In developing alternative nonhuman primate AIDS models for the CCR5 (R5)-tropic SHIVSF162P3N, we characterized virus transmission and infection in Chinese-origin RMs...
  36. McCarthy K, Schmidt A, Kirmaier A, Wyand A, Newman R, Johnson W. Gain-of-sensitivity mutations in a Trim5-resistant primary isolate of pathogenic SIV identify two independent conserved determinants of Trim5? specificity. PLoS Pathog. 2013;9:e1003352 pubmed publisher
    ..This modularity in targeting may be a general feature of Trim5 evolution, permitting different regions of the PRYSPRY domain to evolve independent interactions with capsid...
  37. Jiang J, Kanthaswamy S, Capitanio J. Degree of Chinese ancestry affects behavioral characteristics of infant rhesus macaques (Macaca mulatta). J Med Primatol. 2013;42:20-7 pubmed publisher
    ..However, few studies have examined the effects of varying degrees of Chinese ancestry (DCA) on behavior, and they were typically based on small sample sizes and unusual rearing conditions...
  38. Breed M, Jordan A, Aye P, Lichtveld C, Midkiff C, Schiro F, et al. Loss of a tyrosine-dependent trafficking motif in the simian immunodeficiency virus envelope cytoplasmic tail spares mucosal CD4 cells but does not prevent disease progression. J Virol. 2013;87:1528-43 pubmed publisher
  39. Salazar R, Dotson N, Bressler S, Gray C. Content-specific fronto-parietal synchronization during visual working memory. Science. 2012;338:1097-100 pubmed publisher
    ..These results indicate that short-term memories are represented by large-scale patterns of synchronized activity across the fronto-parietal network...
  40. Lak A, Stauffer W, Schultz W. Dopamine prediction error responses integrate subjective value from different reward dimensions. Proc Natl Acad Sci U S A. 2014;111:2343-8 pubmed publisher
    ..This prediction error response could provide a direct updating signal for economic values. ..
  41. Wonderlich E, Wijewardana V, Liu X, Barratt Boyes S. Virus-encoded TLR ligands reveal divergent functional responses of mononuclear phagocytes in pathogenic simian immunodeficiency virus infection. J Immunol. 2013;190:2188-98 pubmed publisher
    ..The data also suggest that increased responsiveness of mDC to stimulation following SIV infection may be beneficial to the host...
  42. Huang F, Yu W, He Z. Foamy virus in the tree shrew Tupaia belangeri is highly related to simian foamy virus in Macaca mulatta. AIDS Res Hum Retroviruses. 2013;29:1177-8 pubmed publisher
    ..3%) in China. The discovery of FVtup indicated that the tree shrew is a new host of foamy virus. FVtup is highly prevalent in Tupaia in China and there is the possibility of cross-species transmission from nonhuman primate to Tupaia...
  43. Mantini D, Corbetta M, Romani G, Orban G, Vanduffel W. Evolutionarily novel functional networks in the human brain?. J Neurosci. 2013;33:3259-75 pubmed publisher
  44. Jaman M, Huffman M. The effect of urban and rural habitats and resource type on activity budgets of commensal rhesus macaques (Macaca mulatta) in Bangladesh. Primates. 2013;54:49-59 pubmed publisher
    ..Commensal rhesus macaques show a high degree of behavioral flexibility in response to habitat and resource variability, and knowledge of these differences is important for the conservation and management of highly commensal primates...
  45. Quallo M, Kraskov A, Lemon R. The activity of primary motor cortex corticospinal neurons during tool use by macaque monkeys. J Neurosci. 2012;32:17351-64 pubmed publisher
  46. Lemoy M, Lopes D, Reader J, Westworth D, Tarara R. Meningoencephalitis due to Listeria monocytogenes in a pregnant rhesus macaque (Macaca mulatta). Comp Med. 2012;62:443-7 pubmed
    ..spontaneous case of meningoencephalitis due to Listeria monocytogenes in an adult primiparous rhesus macaque (Macaca mulatta) during an outbreak of listeriosis in an outdoor enclosure...
  47. Yang H, Ji X, Zhao G, Ning J, Zhao Q, Aiken C, et al. Structural insight into HIV-1 capsid recognition by rhesus TRIM5?. Proc Natl Acad Sci U S A. 2012;109:18372-7 pubmed publisher
    ..Our results provide molecular insights into the mechanisms of TRIM5?-mediated retroviral restriction...
  48. Sadeghi S, Minor L, Cullen K. Neural correlates of sensory substitution in vestibular pathways following complete vestibular loss. J Neurosci. 2012;32:14685-95 pubmed publisher
    ..the neuronal correlates of this behavioral recovery after complete vestibular loss in alert behaving monkeys (Macaca mulatta)...
  49. Kralik J, Xu E, Knight E, Khan S, Levine W. When less is more: evolutionary origins of the affect heuristic. PLoS ONE. 2012;7:e46240 pubmed publisher
    ..Conservation of this affect heuristic could account for similar 'irrational' biases in humans, and may reflect a more general complexity reduction strategy in which averages, prototypes, or stereotypes represent a set or group. ..
  50. Xie C, Zhang Y, Chen J, Liu C, Zhou W, Li Y, et al. Hominoid-specific de novo protein-coding genes originating from long non-coding RNAs. PLoS Genet. 2012;8:e1002942 pubmed publisher
  51. Hunt P, Lawson C, Gieske M, Murdoch B, Smith H, Marre A, et al. Bisphenol A alters early oogenesis and follicle formation in the fetal ovary of the rhesus monkey. Proc Natl Acad Sci U S A. 2012;109:17525-30 pubmed publisher
    ..Because effects on both stages of oogenesis were elicited using doses that yield circulating levels of BPA analogous to those reported in humans, these findings raise concerns for human reproductive health...
  52. Chiken S, Nambu A. High-frequency pallidal stimulation disrupts information flow through the pallidum by GABAergic inhibition. J Neurosci. 2013;33:2268-80 pubmed publisher
    ..These findings suggest that GPi-DBS dissociates inputs and outputs in the GPi by intense GABAergic inhibition and disrupts information flow through the GPi...
  53. Hansen S, Sacha J, Hughes C, Ford J, Burwitz B, Scholz I, et al. Cytomegalovirus vectors violate CD8+ T cell epitope recognition paradigms. Science. 2013;340:1237874 pubmed publisher
    ..5, Rh157.4, and Rh157.6 (human CMV UL128, UL130, and UL131) genes. Thus, CMV vectors can be genetically programmed to achieve distinct patterns of CD8(+) T cell epitope recognition...
  54. Stoughton C, Lafer Sousa R, Gagin G, Conway B. Psychophysical chromatic mechanisms in macaque monkey. J Neurosci. 2012;32:15216-26 pubmed publisher
    ..The results suggest that color is represented by two cardinal channels early in the processing hierarchy and many chromatic channels in brain regions closer to perceptual readout...
  55. Fiorillo C. Two dimensions of value: dopamine neurons represent reward but not aversiveness. Science. 2013;341:546-9 pubmed publisher
  56. Micci L, Cervasi B, Ende Z, Iriele R, Reyes Aviles E, Vinton C, et al. Paucity of IL-21-producing CD4(+) T cells is associated with Th17 cell depletion in SIV infection of rhesus macaques. Blood. 2012;120:3925-35 pubmed publisher
    ..Further preclinical studies of IL-21 as a potential immunotherapeutic agent for HIV infection may be warranted...