cercocebus atys

Summary

Summary: A species of Old World monkeys from the genera CERCOCEBUS that is important in AIDS research. They may be naturally or experimentally infected with the SIMIAN IMMUNODEFICIENCY VIRUS. They inhabit African forests from Sierra Leone to the Congo Republic.

Top Publications

  1. Sundaravaradan V, Saleem R, Micci L, Gasper M, Ortiz A, Else J, et al. Multifunctional double-negative T cells in sooty mangabeys mediate T-helper functions irrespective of SIV infection. PLoS Pathog. 2013;9:e1003441 pubmed publisher
  2. Brenchley J, Price D, Schacker T, Asher T, Silvestri G, Rao S, et al. Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med. 2006;12:1365-71 pubmed
    ..These data establish a mechanism for chronic immune activation in the context of a compromised gastrointestinal mucosal surface and provide new directions for therapeutic interventions that modify the consequences of acute HIV infection...
  3. Paiardini M, Cervasi B, Engram J, Gordon S, Klatt N, Muthukumar A, et al. Bone marrow-based homeostatic proliferation of mature T cells in nonhuman primates: implications for AIDS pathogenesis. Blood. 2009;113:612-21 pubmed publisher
    ..Collectively, these results indicate that BM is involved in maintaining T-cell homeostasis in primates and suggest a role for BM-based CD4(+) T-cell proliferation in determining the benign nature of natural SIV infection of SMs...
  4. Brenchley J, Paiardini M, Knox K, Asher A, Cervasi B, Asher T, et al. Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections. Blood. 2008;112:2826-35 pubmed publisher
    ..Finally, these data may help account for the nonprogressive nature of nonpathogenic SIV infection in sooty mangabeys...
  5. Mandl J, Akondy R, Lawson B, Kozyr N, Staprans S, Ahmed R, et al. Distinctive TLR7 signaling, type I IFN production, and attenuated innate and adaptive immune responses to yellow fever virus in a primate reservoir host. J Immunol. 2011;186:6406-16 pubmed publisher
  6. Gautam R, Carter A, Katz N, Butler I, Barnes M, Hasegawa A, et al. In vitro characterization of primary SIVsmm isolates belonging to different lineages. In vitro growth on rhesus macaque cells is not predictive for in vivo replication in rhesus macaques. Virology. 2007;362:257-70 pubmed
    ..In vivo, SIVsmm isolates replicated at high levels in all SIVsmm-infected Rh. The poor in vitro replication of primary SIVsmm isolates in Rh cells did not correlate with in vivo replication, emphasizing the value of in vivo studies...
  7. Milush J, Mir K, Sundaravaradan V, Gordon S, Engram J, Cano C, et al. Lack of clinical AIDS in SIV-infected sooty mangabeys with significant CD4+ T cell loss is associated with double-negative T cells. J Clin Invest. 2011;121:1102-10 pubmed publisher
  8. Fruteau C, Range F, Noe R. Infanticide risk and infant defence in multi-male free-ranging sooty mangabeys, Cercocebus atys. Behav Processes. 2010;83:113-8 pubmed publisher
  9. Sundaravaradan V, Mir K, Sodora D. Double-negative T cells during HIV/SIV infections: potential pinch hitters in the T-cell lineup. Curr Opin HIV AIDS. 2012;7:164-71 pubmed publisher
    ..This review summarizes the role of CD3+CD4-CD8- double-negative T cells, which have both regulatory and helper T-cell functions and may have the potential to compensate for the reduced levels of CD4 T cells during SIV/HIV infection...

More Information

Publications67

  1. Engram J, Cervasi B, Borghans J, Klatt N, Gordon S, Chahroudi A, et al. Lineage-specific T-cell reconstitution following in vivo CD4+ and CD8+ lymphocyte depletion in nonhuman primates. Blood. 2010;116:748-58 pubmed publisher
  2. Peeters M, Janssens W, Fransen K, Brandful J, Heyndrickx L, Koffi K, et al. Isolation of simian immunodeficiency viruses from two sooty mangabeys in Côte d'Ivoire: virological and genetic characterization and relationship to other HIV type 2 and SIVsm/mac strains. AIDS Res Hum Retroviruses. 1994;10:1289-94 pubmed
    ..To search for the presence of SIV in sooty mangabeys and other monkey species in Côte d'Ivoire, West Africa, and to compare viral isolates with HIV-2 strains from the same region...
  3. Rout N, Else J, Yue S, Connole M, Exley M, Kaur A. Heterogeneity in phenotype and function of CD8+ and CD4/CD8 double-negative Natural Killer T cell subsets in sooty mangabeys. J Med Primatol. 2010;39:224-34 pubmed publisher
    ..To investigate differences in the two NKT cell subsets, we compared the phenotype and function of sooty mangabey CD8(+) and DN NKT cells...
  4. Sodora D, Allan J, Apetrei C, Brenchley J, Douek D, Else J, et al. Toward an AIDS vaccine: lessons from natural simian immunodeficiency virus infections of African nonhuman primate hosts. Nat Med. 2009;15:861-5 pubmed publisher
  5. Riddick N, Hermann E, Loftin L, Elliott S, Wey W, Cervasi B, et al. A novel CCR5 mutation common in sooty mangabeys reveals SIVsmm infection of CCR5-null natural hosts and efficient alternative coreceptor use in vivo. PLoS Pathog. 2010;6:e1001064 pubmed publisher
  6. Yearley J, Kanagy S, Anderson D, Dalecki K, Pauley D, Suwyn C, et al. Tissue-specific reduction in DC-SIGN expression correlates with progression of pathogenic simian immunodeficiency virus infection. Dev Comp Immunol. 2008;32:1510-21 pubmed publisher
    ..Reduced expression of DC-SIGN in spleen specifically characterizes pathogenic forms of SIV infection, correlates with disease progression, and may contribute to SIV pathogenesis...
  7. Chahroudi A, Bosinger S, Vanderford T, Paiardini M, Silvestri G. Natural SIV hosts: showing AIDS the door. Science. 2012;335:1188-93 pubmed publisher
    ..We highlight the areas that should be pursued in future studies, focusing on potential applications for the treatment and prevention of HIV infection...
  8. Gordon S, Dunham R, Engram J, Estes J, Wang Z, Klatt N, et al. Short-lived infected cells support virus replication in sooty mangabeys naturally infected with simian immunodeficiency virus: implications for AIDS pathogenesis. J Virol. 2008;82:3725-35 pubmed publisher
  9. Silvestri G, Fedanov A, Germon S, Kozyr N, Kaiser W, Garber D, et al. Divergent host responses during primary simian immunodeficiency virus SIVsm infection of natural sooty mangabey and nonnatural rhesus macaque hosts. J Virol. 2005;79:4043-54 pubmed
    ..These studies demonstrate that it is the host response to infection, rather than properties inherent to the virus itself, that causes immunodeficiency in SIV-infected nonhuman primates...
  10. Bostik P, Mayne A, Villinger F, Greenberg K, Powell J, Ansari A. Relative resistance in the development of T cell anergy in CD4+ T cells from simian immunodeficiency virus disease-resistant sooty mangabeys. J Immunol. 2001;166:506-16 pubmed
    ..This function of CD4(+) T cells from SM may contribute to the resistance of this species to SIV-induced disease...
  11. Apetrei C, Kaur A, Lerche N, Metzger M, Pandrea I, Hardcastle J, et al. Molecular epidemiology of simian immunodeficiency virus SIVsm in U.S. primate centers unravels the origin of SIVmac and SIVstm. J Virol. 2005;79:8991-9005 pubmed
    ..The genetic variability of SIVsm strains among PCs may influence the diagnosis and monitoring of SIVsm infection and, consequently, may bias the results of pathogenesis studies...
  12. Ling B, Telfer P, Reed P, Robertson D, Marx P. A link between SIVsm in sooty mangabeys (SM) in wild-living monkeys in Sierra Leone and SIVsm in an American-based SM colony. AIDS Res Hum Retroviruses. 2004;20:1348-51 pubmed
    ..have developed a noninvasive method for SIVsm virion RNA detection in feces of captive sooty mangabeys (SMs) (Cercocebus atys)...
  13. Rout N, Else J, Yue S, Connole M, Exley M, Kaur A. Paucity of CD4+ natural killer T (NKT) lymphocytes in sooty mangabeys is associated with lack of NKT cell depletion after SIV infection. PLoS ONE. 2010;5:e9787 pubmed publisher
  14. Vanderford T, Slichter C, Rogers K, Lawson B, Obaede R, Else J, et al. Treatment of SIV-infected sooty mangabeys with a type-I IFN agonist results in decreased virus replication without inducing hyperimmune activation. Blood. 2012;119:5750-7 pubmed publisher
    ..The results of the present study indicate that administration of type I IFNs in SIV-infected SMs induces a significant anti-viral effect that is not associated with a detectable increase in chronic immune activation...
  15. Silvestri G. Naturally SIV-infected sooty mangabeys: are we closer to understanding why they do not develop AIDS?. J Med Primatol. 2005;34:243-52 pubmed
    Simian immunodeficiency viruses (SIV) infection of sooty mangabey (SM) monkeys (Cercocebus atys), a natural host species, does not induce CD4+ T cell depletion and acquired immunodeficiency syndrome (AIDS) despite chronic high levels of ..
  16. Bosinger S, Li Q, Gordon S, Klatt N, Duan L, Xu L, et al. Global genomic analysis reveals rapid control of a robust innate response in SIV-infected sooty mangabeys. J Clin Invest. 2009;119:3556-72 pubmed publisher
    ..Our findings suggest that active immune regulatory mechanisms, rather than intrinsically attenuated innate immune responses, underlie the low levels of immune activation characteristic of SMs chronically infected with SIV...
  17. Mandl J, Barry A, Vanderford T, Kozyr N, Chavan R, Klucking S, et al. Divergent TLR7 and TLR9 signaling and type I interferon production distinguish pathogenic and nonpathogenic AIDS virus infections. Nat Med. 2008;14:1077-87 pubmed publisher
    ..Such a vicious cycle of continuous virus replication and immunopathology is absent in natural sooty mangabey hosts...
  18. Meythaler M, Wang Z, Martinot A, Pryputniewicz S, Kasheta M, McClure H, et al. Early induction of polyfunctional simian immunodeficiency virus (SIV)-specific T lymphocytes and rapid disappearance of SIV from lymph nodes of sooty mangabeys during primary infection. J Immunol. 2011;186:5151-61 pubmed publisher
    ..These findings suggest that the early SIV-specific T cell response may be an important determinant of lymphoid tissue viral clearance and absence of lymph node immunopathology in natural hosts of SIV infection...
  19. Schindler M, Munch J, Kutsch O, Li H, Santiago M, Bibollet Ruche F, et al. Nef-mediated suppression of T cell activation was lost in a lentiviral lineage that gave rise to HIV-1. Cell. 2006;125:1055-67 pubmed
    ..This function was lost during viral evolution in a lineage that gave rise to HIV-1 and may have predisposed the simian precursor of HIV-1 for greater pathogenicity in humans...
  20. Laurén A, Vödrös D, Thorstensson R, Fenyo E. Comparative studies on mucosal and intravenous transmission of simian immunodeficiency virus (SIVsm): evolution of coreceptor use varies with pathogenic outcome. J Gen Virol. 2006;87:581-94 pubmed
    ..The results indicate that, in the infected host, evolution of SIV coreceptor usage occurs, involving changes in the mode of coreceptor use...
  21. Gordon S, Klatt N, Bosinger S, Brenchley J, Milush J, Engram J, et al. Severe depletion of mucosal CD4+ T cells in AIDS-free simian immunodeficiency virus-infected sooty mangabeys. J Immunol. 2007;179:3026-34 pubmed
  22. Sumpter B, Dunham R, Gordon S, Engram J, Hennessy M, Kinter A, et al. Correlates of preserved CD4(+) T cell homeostasis during natural, nonpathogenic simian immunodeficiency virus infection of sooty mangabeys: implications for AIDS pathogenesis. J Immunol. 2007;178:1680-91 pubmed
    ..The absence of AIDS in these "CD4(low)" naturally SIV-infected SMs defines a protective role of the reduced immune activation even in the context of a significant CD4(+) T cell depletion...
  23. Vanderford T, Demma L, Feinberg M, Staprans S, Logsdon J. Adaptation of a diverse simian immunodeficiency virus population to a new host is revealed through a systematic approach to identify amino acid sites under selection. Mol Biol Evol. 2007;24:660-9 pubmed
  24. McGraw W, Vick A, Daegling D. Sex and age differences in the diet and ingestive behaviors of sooty mangabeys (Cercocebus atys) in the Tai Forest, Ivory Coast. Am J Phys Anthropol. 2011;144:140-53 pubmed publisher
    ..We examined the diet and oral processing activities of sooty mangabeys (Cercocebus atys) in the Ivory Coast's Tai forest from August 2008 to September 2009...
  25. Chakrabarti L. The paradox of simian immunodeficiency virus infection in sooty mangabeys: active viral replication without disease progression. Front Biosci. 2004;9:521-39 pubmed
    ..The comparative analysis of simian models thus suggests that viral load alone cannot account for progression to disease, and that the capacity of primate lentiviruses to induce abnormal immune activation underlies AIDS pathogenesis...
  26. Schindler M, Schmökel J, Specht A, Li H, Munch J, Khalid M, et al. Inefficient Nef-mediated downmodulation of CD3 and MHC-I correlates with loss of CD4+T cells in natural SIV infection. PLoS Pathog. 2008;4:e1000107 pubmed publisher
  27. DeGottardi M, Specht A, Metcalf B, Kaur A, Kirchhoff F, Evans D. Selective downregulation of rhesus macaque and sooty mangabey major histocompatibility complex class I molecules by Nef alleles of simian immunodeficiency virus and human immunodeficiency virus type 2. J Virol. 2008;82:3139-46 pubmed publisher
    ..Thus, selective major histocompatibility complex class I downregulation is a conserved mechanism of immune evasion for pathogenic SIV infection of rhesus macaques and nonpathogenic SIV infection of sooty mangabeys...
  28. Munch J, Schindler M, Wildum S, Rücker E, Bailer N, Knoop V, et al. Primary sooty mangabey simian immunodeficiency virus and human immunodeficiency virus type 2 nef alleles modulate cell surface expression of various human receptors and enhance viral infectivity and replication. J Virol. 2005;79:10547-60 pubmed
    ..is known, however, about the function of nef alleles derived from naturally SIVsm-infected sooty mangabeys (Cercocebus atys) and from human immunodeficiency virus type 2 (HIV-2)-infected individuals...
  29. Rotger M, Dalmau J, Rauch A, McLaren P, Bosinger S, Martinez R, et al. Comparative transcriptomics of extreme phenotypes of human HIV-1 infection and SIV infection in sooty mangabey and rhesus macaque. J Clin Invest. 2011;121:2391-400 pubmed publisher
    ..This work characterizes 2 minimally studied clinical patterns of progression to AIDS, whose analysis may inform our understanding of HIV pathogenesis...
  30. Kaur A, Di Mascio M, Barabasz A, Rosenzweig M, McClure H, Perelson A, et al. Dynamics of T- and B-lymphocyte turnover in a natural host of simian immunodeficiency virus. J Virol. 2008;82:1084-93 pubmed
  31. Ansari A, Onlamoon N, Bostik P, Mayne A, Gargano L, Pattanapanyasat K. Lessons learnt from studies of the immune characterization of naturally SIV infected sooty mangabeys. Front Biosci. 2003;8:s1030-50 pubmed
    ..leprae infection (see Dr. B. Gormus's chapter). Some of our working hypotheses that are aimed to provide explanations for some of these paradoxes are provided herein...
  32. Apetrei C, Gautam R, Sumpter B, Carter A, Gaufin T, Staprans S, et al. Virus subtype-specific features of natural simian immunodeficiency virus SIVsmm infection in sooty mangabeys. J Virol. 2007;81:7913-23 pubmed
    ..Taken together, this systematic analysis of the subtype-specific features of SIV(smm) infection in natural SM hosts identifies subtype-specific differences in the pathogenicity of SIV(smm) infection...
  33. Santiago M, Range F, Keele B, Li Y, Bailes E, Bibollet Ruche F, et al. Simian immunodeficiency virus infection in free-ranging sooty mangabeys (Cercocebus atys atys) from the Taï Forest, Côte d'Ivoire: implications for the origin of epidemic human immunodeficiency virus type 2. J Virol. 2005;79:12515-27 pubmed
  34. Taaffe J, Chahroudi A, Engram J, Sumpter B, Meeker T, Ratcliffe S, et al. A five-year longitudinal analysis of sooty mangabeys naturally infected with simian immunodeficiency virus reveals a slow but progressive decline in CD4+ T-cell count whose magnitude is not predicted by viral load or immune activation. J Virol. 2010;84:5476-84 pubmed publisher
  35. Meythaler M, Martinot A, Wang Z, Pryputniewicz S, Kasheta M, Ling B, et al. Differential CD4+ T-lymphocyte apoptosis and bystander T-cell activation in rhesus macaques and sooty mangabeys during acute simian immunodeficiency virus infection. J Virol. 2009;83:572-83 pubmed publisher
    ..Thus, species-specific differences in the early innate immune response appear to be an important factor contributing to differential immune activation in natural and nonnatural hosts of SIV infection...
  36. Silvestri G, Sodora D, Koup R, Paiardini M, O Neil S, McClure H, et al. Nonpathogenic SIV infection of sooty mangabeys is characterized by limited bystander immunopathology despite chronic high-level viremia. Immunity. 2003;18:441-52 pubmed
    ..Rather, attenuated immune activation enables SIV-infected mangabeys to avoid the bystander damage seen in pathogenic infections and protects them from developing AIDS...
  37. Apetrei C, Lerche N, Pandrea I, Gormus B, Silvestri G, Kaur A, et al. Kuru experiments triggered the emergence of pathogenic SIVmac. AIDS. 2006;20:317-21 pubmed
  38. Kaur A, Yang J, Hempel D, Gritz L, Mazzara G, McClure H, et al. Identification of multiple simian immunodeficiency virus (SIV)-specific CTL epitopes in sooty mangabeys with natural and experimentally acquired SIV infection. J Immunol. 2000;164:934-43 pubmed
    ..Longitudinal studies of viral load and sequence variation in CTL epitopes may provide useful information on the role of CTL in control or persistence of SIV infection in sooty mangabeys...
  39. Paiardini M. Th17 cells in natural SIV hosts. Curr Opin HIV AIDS. 2010;5:166-72 pubmed publisher
    ..To summarize our current understanding of the regulation of Th17 cells in pathogenic and nonpathogenic lentiviral infections...
  40. Daegling D, McGraw W, Ungar P, Pampush J, Vick A, Bitty E. Hard-object feeding in sooty mangabeys (Cercocebus atys) and interpretation of early hominin feeding ecology. PLoS ONE. 2011;6:e23095 pubmed publisher
    ..A modern analog for this specific dietary specialization is provided by the West African sooty mangabey, Cercocebus atys. This species habitually feeds on the large, exceptionally hard nuts of Sacoglottis gabonensis, ..
  41. Paiardini M, Cervasi B, Reyes Aviles E, Micci L, Ortiz A, Chahroudi A, et al. Low levels of SIV infection in sooty mangabey central memory CD⁴⁺ T cells are associated with limited CCR5 expression. Nat Med. 2011;17:830-6 pubmed publisher
    ..These data suggest that low CCR5 expression on sooty mangabey CD4(+) T cells favors the preservation of CD4(+) T cell homeostasis and promotes an AIDS-free status by protecting CD4(+) T(CM) cells from direct virus infection. ..
  42. Milush J, Reeves J, Gordon S, Zhou D, Muthukumar A, Kosub D, et al. Virally induced CD4+ T cell depletion is not sufficient to induce AIDS in a natural host. J Immunol. 2007;179:3047-56 pubmed
    ..disease course is observed during the infection of natural hosts of SIV infection, such as sooty mangabeys (Cercocebus atys), which typically do not progress to AIDS...
  43. Kirmaier A, Wu F, Newman R, Hall L, Morgan J, O Connor S, et al. TRIM5 suppresses cross-species transmission of a primate immunodeficiency virus and selects for emergence of resistant variants in the new species. PLoS Biol. 2010;8: pubmed publisher
    ..Thus, host TRIM5 can suppress viral replication in vivo, exerting selective pressure during the initial stages of cross-species transmission...
  44. Barry A, Silvestri G, Safrit J, Sumpter B, Kozyr N, McClure H, et al. Depletion of CD8+ cells in sooty mangabey monkeys naturally infected with simian immunodeficiency virus reveals limited role for immune control of virus replication in a natural host species. J Immunol. 2007;178:8002-12 pubmed
  45. Ling B, Apetrei C, Pandrea I, Veazey R, Lackner A, Gormus B, et al. Classic AIDS in a sooty mangabey after an 18-year natural infection. J Virol. 2004;78:8902-8 pubmed
    ..Numerous studies have reported that SIV-infected sooty mangabeys (SMs; Cercocebus atys) remain disease free for up to 24 years despite relatively high levels of viral replication...
  46. Estes J, Gordon S, Zeng M, Chahroudi A, Dunham R, Staprans S, et al. Early resolution of acute immune activation and induction of PD-1 in SIV-infected sooty mangabeys distinguishes nonpathogenic from pathogenic infection in rhesus macaques. J Immunol. 2008;180:6798-807 pubmed
    ..These findings point to early control of immune activation by host immunoregulatory mechanisms as a major determinant of the different disease outcomes in SIV infection of natural vs non-natural hosts...
  47. Wang Z, Metcalf B, Ribeiro R, McClure H, Kaur A. Th-1-type cytotoxic CD8+ T-lymphocyte responses to simian immunodeficiency virus (SIV) are a consistent feature of natural SIV infection in sooty mangabeys. J Virol. 2006;80:2771-83 pubmed
  48. Novembre F, de Rosayro J, O Neil S, Anderson D, Klumpp S, McClure H. Isolation and characterization of a neuropathogenic simian immunodeficiency virus derived from a sooty mangabey. J Virol. 1998;72:8841-51 pubmed
    ..This virus should provide an excellent system for investigating the mechanism of lentivirus-induced neurologic disease...
  49. Ray T, McGraw W, Sun Z, Jeon M, Johnson T, Cheffins K, et al. Mandibular bone mineral density variation in three West African Cercopithecoid monkey species: associations with diet and feeding behavior. Arch Oral Biol. 2015;60:1714-20 pubmed publisher
    Procolobus badius, Colobus polykomos, and Cercocebus atys are three West African primate species known to have distinctive feeding behaviors...
  50. Mir K, Bosinger S, Gasper M, Ho O, Else J, Brenchley J, et al. Simian immunodeficiency virus-induced alterations in monocyte production of tumor necrosis factor alpha contribute to reduced immune activation in sooty mangabeys. J Virol. 2012;86:7605-15 pubmed publisher
  51. Cervasi B, Paiardini M, Serafini S, Fraternale A, Menotta M, Engram J, et al. Administration of fludarabine-loaded autologous red blood cells in simian immunodeficiency virus-infected sooty mangabeys depletes pSTAT-1-expressing macrophages and delays the rebound of viremia after suspension of antiretroviral therapy. J Virol. 2006;80:10335-45 pubmed
    ..This study suggests that therapeutic strategies based on the administration of fludarabine-loaded RBC may be further explored as interventions aimed at reducing the size of the M/M reservoirs during chronic HIV infection. ..
  52. Kresge K, Noble S. Keystone 2006. Steady progress presented and discussed at the annual Keystone Symposia on HIV. IAVI Rep. 2006;10:1, 6-12 pubmed
  53. Jaroenpool J, Rogers K, Pattanapanyasat K, Villinger F, Onlamoon N, Crocker P, et al. Differences in the constitutive and SIV infection induced expression of Siglecs by hematopoietic cells from non-human primates. Cell Immunol. 2007;250:91-104 pubmed publisher
    ..The reasons for the failure to detect these molecules at the protein level and the mechanisms for such distinct effects of SIV infection on Siglec expression are discussed. ..
  54. Nigam P, Velu V, Kannanganat S, Chennareddi L, Kwa S, Siddiqui M, et al. Expansion of FOXP3+ CD8 T cells with suppressive potential in colorectal mucosa following a pathogenic simian immunodeficiency virus infection correlates with diminished antiviral T cell response and viral control. J Immunol. 2010;184:1690-701 pubmed publisher
    ..These results also suggest that CD8 Tregs expand in pathogenic immunodeficiency virus infections in the nonnatural hosts and that therapeutic strategies that prevent expansion of these cells may enhance control of HIV infection...
  55. Sharma P, Cohen J, Paul K, Courtney C, Johnson Z, Anderson D. Spontaneous gastric carcinomas in sooty mangabeys (Cercocebus atys). Comp Med. 2011;61:527-31 pubmed
    Sooty mangabeys (Cercocebus atys) are native to West Africa and are a natural host of SIV, which is implicated in the origin of HIV2...
  56. Bostik P, Noble E, Villinger F, Ansari A. Pathogenic and apathogenic courses of SIV infection are associated with distinct and characteristic regulatory patterns of G1/S and G2/M cell cycle checkpoints in CD4+ T cells. AIDS Res Hum Retroviruses. 2006;22:1122-30 pubmed
    ..resistance in these two species, respectively...
  57. Arlet M, Molleman F, Isbell L, Chancellor R, Carey J, Mand R. Correlations between social context and fecal glucocorticoid metabolite concentrations in free-ranging female gray-cheeked mangabeys (Lophocebus albigena) in Kibale National Park, Uganda. Folia Biol (Krakow). 2013;61:239-46 pubmed
    ..We found elevated fGCM concentrations in females when other females in their groups were at the peak of sexual swelling, and when immigrant males joined the group...
  58. Villinger F, Brice G, Mayne A, Bostik P, Ansari A. Control mechanisms of virus replication in naturally SIVsmm infected mangabeys and experimentally infected macaques. Immunol Lett. 1999;66:37-46 pubmed
    ..In vitro analyses of induction of the CD8+ inhibitory function showed that rhesus CD8+ T-cells have the potential to secrete the inhibitory factor(s) prior to SIV infection...