lagomorpha

Summary

Summary: An order of small mammals comprising two families, Ochotonidae (pikas) and Leporidae (RABBITS and HARES). Head and body length ranges from about 125 mm to 750 mm. Hares and rabbits have a short tail, and the pikas lack a tail. Rabbits are born furless and with both eyes and ears closed. HARES are born fully haired with eyes and ears open. All are vegetarians. (From Nowak, Walker's Mammals of the World, 5th ed, p539-41)

Top Publications

  1. Asher R, Meng J, Wible J, McKenna M, Rougier G, Dashzeveg D, et al. Stem Lagomorpha and the antiquity of Glires. Science. 2005;307:1091-4 pubmed
    ..Our results support the hypothesis that rodents and lagomorphs radiated during the Cenozoic and diverged from other placental mammals close to the Cretaceous-Tertiary boundary...
  2. Matthee C, van Vuuren B, Bell D, Robinson T. A molecular supermatrix of the rabbits and hares (Leporidae) allows for the identification of five intercontinental exchanges during the Miocene. Syst Biol. 2004;53:433-47 pubmed
  3. Li Q, Sun R, Huang C, Wang Z, Liu X, Hou J, et al. Cold adaptive thermogenesis in small mammals from different geographical zones of China. Comp Biochem Physiol A Mol Integr Physiol. 2001;129:949-61 pubmed
    ..dauricus to cold is due to an increase in NST and a relaxed homeothermia; and lastly (7) the thyroid hormone is involved in the regulation of cold adaptive thermogenesis in all the species studied...
  4. Yang J, Wang Z, Zhao X, Xu B, Ren Y, Tian H. Natural selection and adaptive evolution of leptin in the ochotona family driven by the cold environmental stress. PLoS ONE. 2008;3:e1472 pubmed publisher
    ..Pikas (order Lagomorpha), endemic, non-hibernating mammals in the modern Holarctic Region, live in cold regions at either high altitudes ..
  5. Lopatin A, Averianov A. The earliest lagomorph (Lagomorpha, Mammalia) from the basal Eocene of Mongolia. Dokl Biol Sci. 2008;419:131-2 pubmed
  6. Carmo C, Esteves P, Ferrand N, van der Loo W. Genetic variation at chemokine receptor CCR5 in leporids: alteration at the 2nd extracellular domain by gene conversion with CCR2 in Oryctolagus, but not in Sylvilagus and Lepus species. Immunogenetics. 2006;58:494-501 pubmed
    ..cuniculus algirus and O. cuniculus cuniculus. Allelic variation at the rabbit CCR5 locus confirmed that the gene conversion predates the subspecies split (1-2 Ma)...
  7. Lin T, Oliver J, Gao L. Molecular characterization of Borrelia isolates from ticks and mammals from the southern United States. J Parasitol. 2004;90:1298-307 pubmed
    ..e., B. burgdorferi s. l. complex and the relapsing fever borreliae complex. The flaB appears to be a useful target gene to screen and identify strains from both B. burgdorferi s. l. and relapsing fever borreliae complexes...
  8. Henry P, Sim Z, Russello M. Genetic evidence for restricted dispersal along continuous altitudinal gradients in a climate change-sensitive mammal: the American Pika. PLoS ONE. 2012;7:e39077 pubmed publisher
  9. Yu N, Zheng C, Zhang Y, Li W. Molecular systematics of pikas (genus Ochotona) inferred from mitochondrial DNA sequences. Mol Phylogenet Evol. 2000;16:85-95 pubmed
    ..These findings support the hypothesis that pikas have entered the steppe environment several times and that morphological similarities within steppe dwellers were due to convergent evolution...

More Information

Publications89

  1. Beever E, Ray C, Mote P, Wilkening J. Testing alternative models of climate-mediated extirpations. Ecol Appl. 2010;20:164-78 pubmed
    ..Results illustrate that extremely rapid distributional shifts can be explained by climatic influences and have implications for conservation topics such as reintroductions and early-warning indicators...
  2. Fostowicz Frelik L, Frelik G. The earliest occurrence of the steppe pika (Ochotona pusilla) in Europe near the Pliocene/Pleistocene boundary. Naturwissenschaften. 2010;97:325-9 pubmed publisher
    ..6 Ma. We present the first reliable record of the earliest O. pusilla entry deep into Europe in the latest Pliocene...
  3. Wang Q, Vuitton D, Xiao Y, Budke C, Campos Ponce M, Schantz P, et al. Pasture types and Echinococcus multilocularis, Tibetan communities. Emerg Infect Dis. 2006;12:1008-10 pubmed
    ..This characteristic was linked to a higher prevalence of Echinococcus multilocularis in dogs and indicates that pasture type may affect E. multilocularis transmission...
  4. Wang J, Zhang Y, Wang D. Seasonal thermogenesis and body mass regulation in plateau pikas (Ochotona curzoniae). Oecologia. 2006;149:373-82 pubmed
  5. Mamirova L, Popadin K, Gelfand M. Purifying selection in mitochondria, free-living and obligate intracellular proteobacteria. BMC Evol Biol. 2007;7:17 pubmed
    ..Here we analyze the influence of these two factors on the strength of the purifying selection in mitochondrial and proteobacterial orthologous genes taking into account the differences in the organism lifestyles...
  6. Rose K, DeLeon V, Missiaen P, Rana R, Sahni A, Singh L, et al. Early Eocene lagomorph (Mammalia) from Western India and the early diversification of Lagomorpha. Proc Biol Sci. 2008;275:1203-8 pubmed publisher
    We report the oldest known record of Lagomorpha, based on distinctive, small ankle bones (calcaneus and talus) from Early Eocene deposits (Middle Ypresian equivalent, ca 53 Myr ago) of Gujarat, west-central India...
  7. van der Loo W, Abrantes J, Esteves P. Sharing of endogenous lentiviral gene fragments among leporid lineages separated for more than 12 million years. J Virol. 2009;83:2386-8 pubmed publisher
    ..We have substantiated this by producing sequence data certifying the sharing of RELIK sequences among leporid lineages that diverged some 12 million years ago...
  8. Lanier H, Olson L. Inferring divergence times within pikas (Ochotona spp.) using mtDNA and relaxed molecular dating techniques. Mol Phylogenet Evol. 2009;53:1-12 pubmed publisher
    ..We also provide evidence that the major splits within the genus occurred in the Miocene, and the Nearctic pikas diverged sometime before the Pleistocene...
  9. Galbreath K, Hafner D, Zamudio K. When cold is better: climate-driven elevation shifts yield complex patterns of diversification and demography in an alpine specialist (American pika, Ochotona princeps). Evolution. 2009;63:2848-63 pubmed publisher
    ..An ecological niche model of past and future pika distributions highlights the influence of climate on species range and indicates that the distribution of genetic diversity may change dramatically with continued climate warming...
  10. Luo Y, Gao W, Gao Y, Tang S, Huang Q, Tan X, et al. Mitochondrial genome analysis of Ochotona curzoniae and implication of cytochrome c oxidase in hypoxic adaptation. Mitochondrion. 2008;8:352-7 pubmed publisher
    ..These amino acid substitutions potentially function in modulation of mitochondrial complexes and electron transport efficiency during cold and hypoxia adaptation...
  11. de Matos A, van der Loo W, Areal H, Lanning D, Esteves P. Study of Sylvilagus rabbit TRIM5? species-specific domain: how ancient endoviruses could have shaped the antiviral repertoire in Lagomorpha. BMC Evol Biol. 2011;11:294 pubmed publisher
    ..Nevertheless, the PRYSPRY v1 region was only 50% similar between these genera. Selection analysis of Lagomorpha TRIM5? proteins identified 25 positively-selected codons, 11 of which are located in the PRYSPRY v1 region, ..
  12. Giraudoux P, Pleydell D, Raoul F, Quéré J, Wang Q, Yang Y, et al. Transmission ecology of Echinococcus multilocularis: what are the ranges of parasite stability among various host communities in China?. Parasitol Int. 2006;55 Suppl:S237-46 pubmed
    ..However, currently the degree of genetic exchange between discrete transmission foci is unknown and it is expected that genetic techniques could provide crucial information regarding this important question...
  13. Esteves P, Lanning D, Ferrand N, Knight K, Zhai S, van der Loo W. The evolution of the immunoglobulin heavy chain variable region (IgVH) in Leporids: an unusual case of transspecies polymorphism. Immunogenetics. 2005;57:874-82 pubmed
    ..The sequence data are furthermore compatible with the hypothesis that the V(H)a polymorphism can be two times older than the divergence time between the Lepus and Oryctolagus lineages, which was estimated at 16-24 million years...
  14. Yang J, Zhao X, Guo S, Li H, Qi D, Wang D, et al. Leptin cDNA cloning and its mRNA expression in plateau pikas (Ochotona curzoniae) from different altitudes on Qinghai-Tibet Plateau. Biochem Biophys Res Commun. 2006;345:1405-13 pubmed
    ..Our results indicated that leptin is sensitive to cold and hypoxia plateau environment and may play one of important roles in pika's ecological adaptation to harsh plateau environment...
  15. Peacock M, Smith A. Nonrandom mating in pikas Ochotona princeps: evidence for inbreeding between individuals of intermediate relatedness. Mol Ecol. 1997;6:801-11 pubmed
    ..These data suggest mate choice in pikas may be based upon intermediate levels of relatedness...
  16. Pinheiro A, Lanning D, Alves P, Mage R, Knight K, van der Loo W, et al. Molecular bases of genetic diversity and evolution of the immunoglobulin heavy chain variable region (IGHV) gene locus in leporids. Immunogenetics. 2011;63:397-408 pubmed publisher
    ..Continued research will help define the roles that genetic, allelic, and population diversity at antibody loci may play in host-parasite interactions...
  17. Yingzhong Y, Yue C, Guoen J, Zhenzhong B, Lan M, Haixia Y, et al. Molecular cloning and characterization of hemoglobin alpha and beta chains from plateau pika (Ochotona curzoniae) living at high altitude. Gene. 2007;403:118-24 pubmed
    ..This study provides essential information for elucidating the possible roles of hemoglobin in adaptation to extremely high altitude in plateau pika...
  18. Kollars T, Oliver J. Host associations and seasonal occurrence of Haemaphysalis leporispalustris, Ixodes brunneus, I. cookei, I. dentatus, and I. texanus (Acari: Ixodidae) in Southeastern Missouri. J Med Entomol. 2003;40:103-7 pubmed
    ..I. dentatus was collected from the cottontail rabbit and Carolina wren throughout the year. I. texanus was collected from the eastern gray squirrel, Virginia opossum, and raccoon throughout the year...
  19. Hoberg E. Coevolution and biogeography among Nematodirinae (Nematoda: Trichostrongylina) Lagomorpha and Artiodactyla (Mammalia): exploring determinants of history and structure for the northern fauna across the holarctic. J Parasitol. 2005;91:358-69 pubmed
    ..Ancestral hosts are represented by Lagomorpha, with evidence for a minimum of 1 host-switching-event and subsequent radiation in the Artiodactyla...
  20. Lemay M, Henry P, Lamb C, Robson K, Russello M. Novel genomic resources for a climate change sensitive mammal: characterization of the American pika transcriptome. BMC Genomics. 2013;14:311 pubmed publisher
    ..To our knowledge, this is the first broad-scale, transcriptome-level study conducted within the Ochotonidae, providing novel genomic resources for studying pika ecology, behaviour and population history. ..
  21. Hoberg E, Pilitt P, Galbreath K. Why museums matter: a tale of pinworms (Oxyuroidea: Heteroxynematidae) among pikas (Ochotona princeps and O. collaris) in the American west. J Parasitol. 2009;95:490-501 pubmed publisher
  22. Schwalm D, Epps C, Rodhouse T, Monahan W, Castillo J, Ray C, et al. Habitat availability and gene flow influence diverging local population trajectories under scenarios of climate change: a place-based approach. Glob Chang Biol. 2016;22:1572-84 pubmed publisher
  23. Sovell J, Holmes J. Efficacy of ivermectin against nematodes infecting field populations of snowshoe hares (Lepus americanus) in Yukon, Canada. J Wildl Dis. 1996;32:23-30 pubmed
    ..Overall, ivermectin was not as effective against the nematodes of free-ranging hares as has been reported for nematodes of domestic and laboratory animals. ..
  24. Yamada F, Takaki M, Suzuki H. Molecular phylogeny of Japanese Leporidae, the Amami rabbit Pentalagus furnessi, the Japanese hare Lepus brachyurus, and the mountain hare Lepus timidus, inferred from mitochondrial DNA sequences. Genes Genet Syst. 2002;77:107-16 pubmed
  25. Apanaskevich D, Duan W, Apanaskevich M, Filippova N, Chen J. Redescription of Dermacentor everestianus Hirst (Acari: Ixodidae), a parasite of mammals in mountains of China and Nepal with synonymization of D. abaensis Teng and D. birulai Olenev. J Parasitol. 2014;100:268-78 pubmed publisher
    ..So far, D. everestianus is found only in China and Nepal, where the adults were collected from domestic and wild ungulates while the immature stages were recorded from lagomorphs and rodents. ..
  26. Audebert F, Cassone J, Baccam D, Kerboeuf D, Durette Desset M. The life cycle of Ohbayashinema erbaevae (Nematoda, Heligmosomoidea, Heligmosomidae) in Ochotona rufescens rufescens (Ochotonidae). Parasite. 2001;8:325-33 pubmed
  27. Crossley D. Oral biology and disorders of lagomorphs. Vet Clin North Am Exot Anim Pract. 2003;6:629-59 pubmed
    ..If you are not confident in your ability or do not have the best equipment for the job, the client should be informed and offered the opportunity to be referral to a "specialist." ..
  28. Wang C, He H, Li M, Lei F, Root J, Wu Y, et al. Parasite species associated with wild plateau pika (Ochotona curzoniae) in southeastern Qinghai Province, China. J Wildl Dis. 2009;45:288-94 pubmed
    ..These data provide evidence of a natural biologic control mechanism of plateau pika on grassland habitats, and may be of use for identifying the mechanism of transmission of parasites between plateau pika, livestock, and humans. ..
  29. de Sousa Pereira P, Abrantes J, Baldauf H, Keppler O, Esteves P. Evolutionary study of leporid CD4 reveals a hotspot of genetic variability within the D2 domain. Immunogenetics. 2016;68:477-482 pubmed publisher
  30. Silvers L, Barnard D, Knowlton F, Inglis B, Labudovic A, Holland M, et al. Host-specificity of myxoma virus: Pathogenesis of South American and North American strains of myxoma virus in two North American lagomorph species. Vet Microbiol. 2010;141:289-300 pubmed publisher
    ..MSW did not reach transmissible titres at the inoculation site in either species. This might explain why the Californian myxoma virus has not expanded its host-range in North America. ..
  31. ValcÁrcel F, SÁnchez J, Jaime J, Basco Basco P, Guajardo S, Cutuli M, et al. Control of Tick Infestations in Oryctolagus cuniculus (Lagomorpha: Leporidae) With Spinosad Under Laboratory and Field Conditions. J Med Entomol. 2015;52:207-13 pubmed publisher
    ..00 (Day 0) to 26.09 ticks per ear in treated rabbits (Day 16), whereas controls maintained the infection (46.64). This strategy could be useful as an alternative or supplement to traditional acaricides in tick control programs. ..
  32. Li H, Ren Y, Guo S, Cheng L, Wang D, Yang J, et al. The protein level of hypoxia-inducible factor-1alpha is increased in the plateau pika (Ochotona curzoniae) inhabiting high altitudes. J Exp Zool A Ecol Genet Physiol. 2009;311:134-41 pubmed publisher
    ..Our study suggests that the HIF-1alpha protein levels are related to the adaptation of the plateau pika to the high-altitude hypoxic environment. ..
  33. Treml F, Hubalek Z, Halouzka J, Juricová Z, Hunady M, Janik V. [Analysis of the incidence of tularemia in the Breclav District 1994-1999]. Epidemiol Mikrobiol Imunol. 2001;50:4-9 pubmed
    ..One of the important factors of the environment are susceptible individuals (hares, small terrestrial mammals) as well as blood sucking arthropods as vectors of the disease. ..
  34. Cai K, Bai J, Chen S. Two new species of Schizorchis (Cestoda: Anoplocephalidae) from leporids (Lagomorpha: Leporidae) in China. J Parasitol. 2012;98:977-84 pubmed publisher
    ..Schizorchis sinensis sp. n. is distinguished from all the species in the genus from pikas, Ochotona spp. (Lagomorpha: Ochotonidae) by having much longer strobila, a larger cirrus sac, a greater number of segments, and more ..
  35. Pankovics P, Boros Ã, Bíró H, Horváth K, Phan T, Delwart E, et al. Novel picornavirus in domestic rabbits (Oryctolagus cuniculus var. domestica). Infect Genet Evol. 2016;37:117-22 pubmed publisher
    ..infect numerous vertebrate species from fish to mammals, but have not been identified in a member of the Lagomorpha order (pikas, hares and rabbits). In this study, a novel picornavirus was identified in 16 (28...
  36. Boonstra R, Takagi N, Bissoon N, Vij S, Gurd J. Trapping-induced changes in expression of the N-methyl-D-aspartate receptor in the hippocampus of snowshoe hares. Neurosci Lett. 2002;324:173-6 pubmed
    ..These results suggest that stress associated with the trapping experience may adversely affect the structure and/or function of the NMDA receptor. ..
  37. Licón Luna R. First report of myxomatosis in Mexico. J Wildl Dis. 2000;36:580-3 pubmed
  38. Jeffress M, Rodhouse T, Ray C, Wolff S, Epps C. The idiosyncrasies of place: geographic variation in the climate-distribution relationships of the American pika. Ecol Appl. 2013;23:864-78 pubmed
    ..The hierarchical approach to modeling provides a coherent conceptual and technical framework for gaining these insights. ..
  39. Pacheco R, Moraes Filho J, Guedes E, Silveira I, Richtzenhain L, Leite R, et al. Rickettsial infections of dogs, horses and ticks in Juiz de Fora, southeastern Brazil, and isolation of Rickettsia rickettsii from Rhipicephalus sanguineus ticks. Med Vet Entomol. 2011;25:148-55 pubmed publisher
    ..Overall, the results of the present study indicate a potential risk for transmission of R. rickettsii to humans by Rh. sanguineus, an occurrence yet to be documented in Brazil...
  40. Głodek J, Adamiak Z, Przeworski A. Magnetic Resonance Imaging of Reptiles, Rodents, and Lagomorphs for Clinical Diagnosis and Animal Research. Comp Med. 2016;66:216-9 pubmed
    ..Protocols for the anesthesia and immobilization of subjects to facilitate their imaging are discussed also. ..
  41. Ge D, Wen Z, Xia L, Zhang Z, Erbajeva M, Huang C, et al. Evolutionary history of lagomorphs in response to global environmental change. PLoS ONE. 2013;8:e59668 pubmed publisher
    Although species within Lagomorpha are derived from a common ancestor, the distribution range and body size of its two extant groups, ochotonids and leporids, are quite differentiated...
  42. Lemos de Matos A, de Sousa Pereira P, Lissovsky A, van der Loo W, Melo Ferreira J, Cui J, et al. Endogenization of mouse mammary tumor virus (MMTV)-like elements in genomes of pikas (Ochotona sp.). Virus Res. 2015;210:22-6 pubmed publisher
    ..European rabbit exclusive endogenous gammaretrovirus, until now no exogenous retroviruses have been isolated in Lagomorpha species...
  43. Pinheiro A, Neves F, Lemos de Matos A, Abrantes J, van der Loo W, Mage R, et al. An overview of the lagomorph immune system and its genetic diversity. Immunogenetics. 2016;68:83-107 pubmed publisher
  44. Thompson C, Gese E. Food webs and intraguild predation: community interactions of a native mesocarnivore. Ecology. 2007;88:334-46 pubmed
    ..While predation by coyotes may be the specific cause of swift fox mortality in this system, the more general mechanism appears to be exposure to predation moderated by shrub density. ..
  45. Camp M, Shipley L, Milling C, Rachlow J, Forbey J. Interacting effects of ambient temperature and food quality on the foraging ecology of small mammalian herbivores. J Therm Biol. 2018;71:83-90 pubmed publisher
  46. Slansky F, Huckabee J. First records of rodent-infesting Cuterebra bot flies parasitizing raccoons (Procyon lotor) in North America. J Parasitol. 2006;92:1369-73 pubmed
    ..g., mice, rats, and tree squirrels) or Lagomorpha (e.g., rabbits and hares) in the Americas...
  47. Haerer G, Nicolet J, Bacciarini L, Gottstein B, Giacometti M. [Causes of death, zoonoses, and reproduction in the European brown hare in Switzerland]. Schweiz Arch Tierheilkd. 2001;143:193-201 pubmed
    ..This phenomenon is rather a cause of a reduced survival rate in leverets...
  48. Lindstrom J, Ranta E, Kokko H, Lundberg P, Kaitala V. From arctic lemmings to adaptive dynamics: Charles Elton's legacy in population ecology. Biol Rev Camb Philos Soc. 2001;76:129-58 pubmed
  49. Chi C, Lin C, Liao I, Yao Y, Shen F, Liu C, et al. Panton-Valentine leukocidin facilitates the escape of Staphylococcus aureus from human keratinocyte endosomes and induces apoptosis. J Infect Dis. 2014;209:224-35 pubmed publisher
    ..These findings indicate that PVL is an important virulence factor that enables CA-MRSA to produce necrotizing skin infections by allowing the bacteria to escape from endosomes, replicate intracellularly, and induce apoptosis. ..
  50. Liu M, Cao G, Zhang Y, Qu J, Li W, Wan X, et al. Changes in the morphology and protein expression of germ cells and Sertoli cells in plateau pikas testes during non-breeding season. Sci Rep. 2016;6:22697 pubmed publisher
  51. Hadamitzky C, Pabst R. Acquired lymphedema: an urgent need for adequate animal models. Cancer Res. 2008;68:343-5 pubmed publisher
    ..As a result, animal models have provided an important research base. This review summarizes work in canine, rabbit, and rodent models of acquired lymphedema, focusing on arising limitations and potential applications...
  52. Beever E, Dobrowski S, Long J, Mynsberge A, Piekielek N. Understanding relationships among abundance, extirpation, and climate at ecoregional scales. Ecology. 2013;94:1563-71 pubmed
    ..Our results emphasize the need to clarify mechanisms underlying biotic responses to recent climate change at organism-relevant scales, to inform management and conservation strategies for species of concern...
  53. Lynch A, Duszynski D, Cook J. Species of coccidia (Apicomplexa: Eimeriidae) infecting pikas from Alaska, U.S.A. and northeastern Siberia, Russia. J Parasitol. 2007;93:1230-4 pubmed publisher
    ..cryptobarretti and I. marquardti. Only minor quantitative differences were seen between the sporulated oocysts we studied and those reported in their original descriptions...
  54. Zhu R, Rao X, Wei D, Wang D, Wei L, Sun S. [Functional difference of malate-aspartate shuttle system in liver between plateau zokor (Myospalax baileyi) and plateau pika (Ochotona curzoniae)]. Sheng Li Xue Bao. 2012;64:177-86 pubmed
    ..As a result, plateau pika converts the lactic acid quickly produced in their skeletal muscle by anaerobic glycolysis and reduces dependence on the oxygen...
  55. Jezyk D, Jerzemowski J, Grzybiak M. Provision of tricuspid valve leaflets by septal papillary muscles in the right ventricle of human and other mammal hearts. Folia Morphol (Warsz). 2003;62:309-11 pubmed
    ..The material examined consisted of 299 hearts of mammals (Primates, Ungulata, Carnivora, Lagomorpha, Rodentia, Marsupialia)...
  56. Teskey Gerstl A, Bamberg E, Steineck T, Palme R. Excretion of corticosteroids in urine and faeces of hares (Lepus europaeus). J Comp Physiol B. 2000;170:163-8 pubmed
    ..Based on these results, measuring 11,17-dioxoandrostanes in faeces enables non-invasive monitoring of disturbances in hares and thus provides a tool for field investigations elucidating the role of stress in hare populations...
  57. Federico P, Gross L, Lenhart S, Ryan D. Optimal control in individual-based models: implications from aggregated methods. Am Nat. 2013;181:64-77 pubmed publisher
    ..This suggests investigation of a mixture of simplified models in conjunction with detailed simulation models when individual differences affect population processes...
  58. Barrio I, Hik D, Peck K, Bueno C. After the frass: foraging pikas select patches previously grazed by caterpillars. Biol Lett. 2013;9:20130090 pubmed publisher
    ..Even among distantly related taxa, such interactions where one herbivore is cueing on the foraging of another, could drive the creation of herbivory hotspots, with cascading consequences for ecosystem processes...
  59. Gorski J, Mizak B, Chrobocińska M. Control of rabbit myxomatosis in Poland. Rev Sci Tech. 1994;13:869-79 pubmed
    ..The long-term stability, safety and efficacy of the vaccine are demonstrated. Laboratory experiments were confirmed in large-scale field observations...
  60. Bhattacharyya S, Adhikari B, Rawat G. Forage selection by Royle's pika (Ochotona roylei) in the western Himalaya, India. Zoology (Jena). 2013;116:300-6 pubmed publisher
    ..The parameter estimates of best fit models indicate that the influence of leaf size or amount of avoided substance on pika forage selection was modulated by the magnitude of predation risk...
  61. Innokent eva T, Korzun V, Mashkovskiĭ I, Mikhailov E, Chipanin E, Fomina L, et al. [Epizootological role of fleas in the Gorno-Altai natural plague focus (a review)]. Parazitologiia. 2004;38:273-87 pubmed
    ..pestis in the Gorno-Altai natural focus. Certain combinations of structural elements of the flea taxocenosis have a dominant significance in determination the circulation process at different phases of the annual epizootic cycle...
  62. Erb L, Ray C, Guralnick R. On the generality of a climate-mediated shift in the distribution of the American pika (Ochotona princeps). Ecology. 2011;92:1730-5 pubmed
    ..While there was no climate change signal in our results, these data provide valuable insight into the potential future effects of climate change on O. princeps throughout its range...
  63. Goethert H, Telford S. Enzootic transmission of Anaplasma bovis in Nantucket cottontail rabbits. J Clin Microbiol. 2003;41:3744-7 pubmed
    ..bovis within rabbits, as determined by PCR of blood samples, was 18%. Haemaphysalis leporispalustris appears to serve as vector. The public health (human or veterinary) significance of this finding remains speculative...
  64. Bertolino S, Hofmannová L, Girardello M, Modry D. Richness, origin and structure of an Eimeria community in a population of Eastern cottontail (Sylvilagus floridanus) introduced into Italy. Parasitology. 2010;137:1179-86 pubmed publisher
    ..This was made evident by the low co-occurrence of E. environ and E. neoirresidua with E. poudrei, E. honessi, and E. maior...
  65. Labuda M, Eleckova E, Licková M, Sabó A. Tick-borne encephalitis virus foci in Slovakia. Int J Med Microbiol. 2002;291 Suppl 33:43-7 pubmed
    ..A part of these cases (33 cases during the last 5 years) are alimentary infections after drinking of raw goat and sheep milk...
  66. Pretorius A, Oelofsen M, Smith M, van der Ryst E. The binding potential of commercial antibody conjugates with sera of various small terrestrial mammals. Onderstepoort J Vet Res. 1997;64:201-3 pubmed
    ..It was found that sera from some species of the order Lagomorpha bound optimally to anti-rabbit IgG, while anti-mouse IgG could be used for most species of Rodentia...
  67. Huchon D, Madsen O, Sibbald M, Ament K, Stanhope M, Catzeflis F, et al. Rodent phylogeny and a timescale for the evolution of Glires: evidence from an extensive taxon sampling using three nuclear genes. Mol Biol Evol. 2002;19:1053-65 pubmed publisher
    ..The phylogenetic results significantly support rodent monophyly, the association of Rodentia with Lagomorpha (the Glires clade), and a Glires + Euarchonta (Primates, Dermoptera, and Scandentia) clade...
  68. Okamura K, Wintle R, Scherer S. Characterization of the differentially methylated region of the Impact gene that exhibits Glires-specific imprinting. Genome Biol. 2008;9:R160 pubmed publisher
  69. Frolich K, Haerer G, Bacciarini L, Janovsky M, Rudolph M, Giacometti M. European brown hare syndrome in free-ranging European brown and mountain hares from Switzerland. J Wildl Dis. 2001;37:803-7 pubmed
    ..Antibodies against EBHSV were not detected in any of the sera of European brown hares, and EBHSV-antigen was not found in the samples of mountain hares. This is the first report of EBHS in European brown hares from Switzerland...
  70. McIntire E, Hik D. Influences of chronic and current season grazing by collared pikas on above-ground biomass and species richness in subarctic alpine meadows. Oecologia. 2005;145:288-97 pubmed
    ..Infrequent herbivore vacancies may provide local short-term release from pika grazing, thereby contributing to the persistence of productive, highly palatable vegetation...
  71. Afonso E, Thulliez P, Pontier D, Gilot Fromont E. Toxoplasmosis in prey species and consequences for prevalence in feral cats: not all prey species are equal. Parasitology. 2007;134:1963-71 pubmed
    ..Overall, our results suggest that the composition of prey items in cat diet influences the risk of T. gondii infection. Prey compositon should therefore be considered important in any understanding of infection dynamics of T. gondii...
  72. Palmer K, Stanton N, Ben David M, Mionczynski J, Williams S. Are pikas exposed to and affected by selenium deficiency?. J Wildl Dis. 2007;43:475-84 pubmed
    ..Whether Se levels influence reproductive success of pikas is unknown and should be the focus of future studies...
  73. Amaral K, Palace M, O Brien K, Fenderson L, Kovach A. Anthropogenic Habitats Facilitate Dispersal of an Early Successional Obligate: Implications for Restoration of an Endangered Ecosystem. PLoS ONE. 2016;11:e0148842 pubmed publisher
    ..In fragmented landscapes, human-modified habitats may enhance functional connectivity by providing suitable dispersal conduits for early successional specialists. ..
  74. Koh H, Chun T, Yoo H, Zhang Y, Wang J, Zhang M, et al. Mitochondrial cytochrome b gene sequence diversity in the Korean hare, Lepus coreanus Thomas (Mammalia, Lagomorpha). Biochem Genet. 2001;39:417-29 pubmed
    ..coreanus from North Korea and other species of Lepus from eastern Asia are needed to clarify the taxonomic status of the divergent mtDNA clades of L. mandshuricus and L. sinensis...
  75. Apanaskevich D. First description of the nymph and larva of Dermacentor raskemensis (Acari: Ixodidae), parasites of pikas and other small mammals in Central Asia. J Med Entomol. 2013;50:959-64 pubmed
    ..The nymphs and larvae of D. raskemensis studied originate from Afghanistan, India, Iran, and Pakistan, where they were collected from pikas and other small mammals...
  76. Pinne M, Choy H, Haake D. The OmpL37 surface-exposed protein is expressed by pathogenic Leptospira during infection and binds skin and vascular elastin. PLoS Negl Trop Dis. 2010;4:e815 pubmed publisher
    ..Thus, OmpL37 is a novel elastin-binding protein of pathogenic Leptospira that may be promoting attachment of Leptospira to host tissues...
  77. Yang J, Bromage T, Zhao Q, Xu B, Gao W, Tian H, et al. Functional evolution of leptin of Ochotona curzoniae in adaptive thermogenesis driven by cold environmental stress. PLoS ONE. 2011;6:e19833 pubmed publisher
    ..Leptin is a key hormone related to how these animals regulate energy homeostasis. Previous molecular evolutionary analysis helped to generate the hypothesis that adaptive evolution of plateau pika leptin may be driven by cold stress...
  78. Erb L, Ray C, Guralnick R. Determinants of pika population density vs. occupancy in the Southern Rocky Mountains. Ecol Appl. 2014;24:429-35 pubmed
    ..Conversely, populations at highest risk for declining density and extirpation are likely to be those in sites with poor-quality vegetation...
  79. Yap M, Stoye J. Apparent effect of rabbit endogenous lentivirus type K acquisition on retrovirus restriction by lagomorph Trim5?s. Philos Trans R Soc Lond B Biol Sci. 2013;368:20120498 pubmed publisher
    ..2 domain from the pika, which lacks RELIK. Taken together, these results could suggest that the pika had not been exposed to exogenous RELIK and that endogenized RELIK might exert a selective pressure on lagomorph TRIM5?. ..
  80. Martin M, Shepherdson D. Role of familiarity and preference in reproductive success in ex situ breeding programs. Conserv Biol. 2012;26:649-56 pubmed publisher
    ..Our findings are consistent with the idea that allowing mate choice and familiarity increase the reproductive success of captive-breeding programs for endangered species...