puma

Summary

Summary: A genus in the family FELIDAE comprising one species, Puma concolor. It is a large, long-tailed, feline of uniform color. The names puma, cougar, and mountain lion are used interchangeably for this species. There are more than 20 subspecies.

Top Publications

  1. Sperka T, Song Z, Morita Y, Nalapareddy K, Guachalla L, Lechel A, et al. Puma and p21 represent cooperating checkpoints limiting self-renewal and chromosomal instability of somatic stem cells in response to telomere dysfunction. Nat Cell Biol. 2011;14:73-9 pubmed publisher
    The tumour suppressor p53 activates Puma-dependent apoptosis and p21-dependent cell-cycle arrest in response to DNA damage...
  2. Sondgeroth K, Leutenegger C, Vandewoude S. Development and validation of puma (Felis concolor) cytokine and lentivirus real-time PCR detection systems. Vet Immunol Immunopathol. 2005;104:205-13 pubmed
    ..b>Puma (Felis concolor) lentivirus (PLV) is closely related to FIV, but based on phylogenetic and clinical studies, is ..
  3. Franklin S, Troyer J, TerWee J, Lyren L, Boyce W, Riley S, et al. Frequent transmission of immunodeficiency viruses among bobcats and pumas. J Virol. 2007;81:10961-9 pubmed
    ..Lentivirus seroprevalence was determined for 79 bobcats (Lynx rufus) and 31 pumas (Puma concolor) from well-defined populations in Southern California...
  4. Quadros R, Pilati C, Marques S, Mazzolli M, Benedet R. Capillaria hepatica in Puma concolor: first report in Brazil. J Zoo Wildl Med. 2009;40:586-7 pubmed
    ..hepatica eggs, surrounded by mononuclear inflammatory cell infiltrate, small foci of necrosis, and mild-to-moderate fibrosis. This is the first report of C. hepatica in cougars (Puma concolor) in Brazil.
  5. Newman J, Zillioux E, Rich E, Liang L, Newman C. Historical and other patterns of monomethyl and inorganic mercury in the Florida panther (Puma concolor coryi). Arch Environ Contam Toxicol. 2005;48:75-80 pubmed
    Since the late 1980s, elevated levels of mercury have been reported in the tissues of the Florida panther (Puma concolor coryi) from the Florida Everglades...
  6. Terwee J, Yactor J, Sondgeroth K, Vandewoude S. Puma lentivirus is controlled in domestic cats after mucosal exposure in the absence of conventional indicators of immunity. J Virol. 2005;79:2797-806 pubmed
    A high percentage of free-ranging pumas (Felis concolor) are infected with feline lentiviruses (puma lentivirus, feline immunodeficiency virus Pco [FIV-Pco], referred to here as PLV) without evidence of disease...
  7. Poss M, Ross H, Painter S, Holley D, Terwee J, Vandewoude S, et al. Feline lentivirus evolution in cross-species infection reveals extensive G-to-A mutation and selection on key residues in the viral polymerase. J Virol. 2006;80:2728-37 pubmed publisher
    ..host species, we evaluated the molecular evolution of a feline immunodeficiency virus derived from a wild cougar, Puma concolor, during infection of domestic cats...
  8. Franklin S, Troyer J, Terwee J, Lyren L, Kays R, Riley S, et al. Variability in assays used for detection of lentiviral infection in bobcats (Lynx rufus), pumas (Puma concolor), and ocelots (Leopardus pardalis). J Wildl Dis. 2007;43:700-10 pubmed
    ..pumas (Felis concolor), and ocelots (Leopardus pardalis) for exposure to lentivirus using five different assays: puma lentivirus (PLV), African lion lentivirus (LLV), and domestic cat FIV-based immunoblots, a commercially available ..
  9. Robinson H, Wielgus R, Cooley H, Cooley S. Sink populations in carnivore management: cougar demography and immigration in a hunted population. Ecol Appl. 2008;18:1028-37 pubmed
    ..For example, hunted cougar (Puma concolor) populations have shown a great degree of resiliency...

More Information

Publications149 found, 100 shown here

  1. Haag T, Santos A, De Angelo C, Srbek Araujo A, Sana D, Morato R, et al. Development and testing of an optimized method for DNA-based identification of jaguar (Panthera onca) and puma (Puma concolor) faecal samples for use in ecological and genetic studies. Genetica. 2009;136:505-12 pubmed publisher
    ..In this study we describe a sequence-based approach that efficiently distinguishes jaguar versus puma scats, and that presents several desirable properties: (1) considerably high amplification and sequencing rates; (2)..
  2. Elbroch L, Wittmer H. Table scraps: inter-trophic food provisioning by pumas. Biol Lett. 2012;8:776-9 pubmed publisher
    ..Pumas (Puma concolor) are an elusive, cryptic species difficult to study and little is known about their inter-trophic-level ..
  3. Jansen B, Jenks J. Birth timing for mountain lions (Puma concolor); testing the prey availability hypothesis. PLoS ONE. 2012;7:e44625 pubmed publisher
    We investigated potential advantages in birth timing for mountain lion (Puma concolor) cubs. We examined cub body mass, survival, and age of natal dispersal in relation to specific timing of birth...
  4. McRae B, Beier P, Dewald L, Huynh L, Keim P. Habitat barriers limit gene flow and illuminate historical events in a wide-ranging carnivore, the American puma. Mol Ecol. 2005;14:1965-77 pubmed
    We examined the effects of habitat discontinuities on gene flow among puma (Puma concolor) populations across the southwestern USA...
  5. Wyttenbach A, Tolkovsky A. The BH3-only protein Puma is both necessary and sufficient for neuronal apoptosis induced by DNA damage in sympathetic neurons. J Neurochem. 2006;96:1213-26 pubmed
    ..cytosine arabinoside is a DNA damaging drug that induces the expression of the BH3-only pro-apoptotic genes Noxa, Puma and Bim...
  6. Roelke M, Pecon Slattery J, Taylor S, Citino S, Brown E, Packer C, et al. T-lymphocyte profiles in FIV-infected wild lions and pumas reveal CD4 depletion. J Wildl Dis. 2006;42:234-48 pubmed
    ..of virus and host in free-ranging FIV-Ple-infected African lions (Panthera leo) and FIV-Pco-infected pumas (Puma concolor) populations...
  7. Dubey J, Quirk T, Pittt J, Sundar N, Velmurugan G, Kwok O, et al. Isolation and genetic characterization of Toxoplasma gondii from raccoons (Procyon lotor), cats (Felis domesticus), striped skunk (Mephitis mephitis), black bear (Ursus americanus), and cougar (Puma concolor) from Canada. J Parasitol. 2008;94:42-5 pubmed publisher
    ..These results are in contrast with the Type II genotype that is widespread in domestic animals and humans throughout the United States and Europe. This is the first genotyping of T. gondii isolates from this part of North America...
  8. Cunningham M, Brown M, Shindle D, Terrell S, Hayes K, Ferree B, et al. Epizootiology and management of feline leukemia virus in the Florida puma. J Wildl Dis. 2008;44:537-52 pubmed
    Feline leukemia virus (FeLV) was not detected in Florida pumas (Puma concolor coryi) in almost 20 yr of surveillance; however, the finding of two FeLV antigen-positive pumas during the 2002-2003 capture season led to an investigation of ..
  9. Vandewoude S, Troyer J, Poss M. Restrictions to cross-species transmission of lentiviral infection gleaned from studies of FIV. Vet Immunol Immunopathol. 2010;134:25-32 pubmed publisher
    ..from this observation is apparent cross-species transmission of FIV between bobcats (Lynx rufus) and pumas (Puma concolor) in Southern California that has occurred at least three times; evidence from one bobcat sequence suggests ..
  10. Bevins S, Tracey J, Franklin S, Schmit V, Macmillan M, Gage K, et al. Wild felids as hosts for human plague, Western United States. Emerg Infect Dis. 2009;15:2021-4 pubmed publisher
    ..High levels of exposure in plague-endemic regions indicate the need to consider the ecology and pathobiology of plague in nondomestic felid hosts to better understand the role of these species in disease persistence and transmission...
  11. Happo L, Cragg M, Phipson B, Haga J, Jansen E, Herold M, et al. Maximal killing of lymphoma cells by DNA damage-inducing therapy requires not only the p53 targets Puma and Noxa, but also Bim. Blood. 2010;116:5256-67 pubmed publisher
    ..In nontransformed lymphoid cells, the combined loss of 2 proapoptotic p53 target genes, Puma and Noxa, induces as much resistance to DNA damage as loss of p53 itself...
  12. Pena H, Marvulo M, Horta M, Silva M, Silva J, Siqueira D, et al. Isolation and genetic characterisation of Toxoplasma gondii from a red-handed howler monkey (Alouatta belzebul), a jaguarundi (Puma yagouaroundi), and a black-eared opossum (Didelphis aurita) from Brazil. Vet Parasitol. 2011;175:377-81 pubmed publisher
    ..in mice from tissues of a young male red handed howler monkey (Alouatta belzebul), an adult male jaguarundi (Puma yagouaroundi), and an adult female black-eared opossum (Didelphis aurita)...
  13. Brown M, Cunningham M, Roca A, Troyer J, Johnson W, O Brien S. Genetic characterization of feline leukemia virus from Florida panthers. Emerg Infect Dis. 2008;14:252-9 pubmed publisher
    From 2002 through 2005, an outbreak of feline leukemia virus (FeLV) occurred in Florida panthers (Puma concolor coryi). Clinical signs included lymphadenopathy, anemia, septicemia, and weight loss; 5 panthers died...
  14. Wilmers C, Wang Y, Nickel B, Houghtaling P, Shakeri Y, Allen M, et al. Scale dependent behavioral responses to human development by a large predator, the puma. PLoS ONE. 2013;8:e60590 pubmed publisher
    ..Here we provide a novel approach to estimating the spatial scale at which a top predator, the puma (Puma concolor), responds to human development when it is moving, feeding, communicating, and denning...
  15. Teichman K, Cristescu B, Nielsen S. Does sex matter? Temporal and spatial patterns of cougar-human conflict in British Columbia. PLoS ONE. 2013;8:e74663 pubmed publisher
    ..We investigated the importance of cougar (Puma concolor) habitat, human landscape characteristics and the combination of habitat and human features on the ..
  16. Vartak S, Iyer D, Santhoshkumar T, Sharma S, Mishra A, Goldsmith G, et al. Novel BCL2 inhibitor, Disarib induces apoptosis by disruption of BCL2-BAK interaction. Biochem Pharmacol. 2017;131:16-28 pubmed publisher
    ..disrupted the BCL2-BAK interaction, but not that of BCL2-BAX or other members of the proapoptotic family such as PUMA and BIM, in vitro...
  17. Yang S, Li X, Guan W, Qian M, Yao Z, Yin X, et al. NVP-BKM120 inhibits colon cancer growth via FoxO3a-dependent PUMA induction. Oncotarget. 2017;8:83052-83062 pubmed publisher
    ..We found that NVP-BKM120 treatment enhance PUMA induction irrespective of p53 status through the FoxO3a pathway following AKT inhibition...
  18. Dai H, Ding H, Meng X, Peterson K, Schneider P, Karp J, et al. Constitutive BAK activation as a determinant of drug sensitivity in malignant lymphohematopoietic cells. Genes Dev. 2015;29:2140-52 pubmed publisher
    ..The extent of this constitutive BAK oligomerization is diminished by BAK knockdown and unaffected by BIM or PUMA down-regulation...
  19. Kim K, Jang W, Lee J, Jun D, Ko J, Yun Y, et al. Kaempferol Activates Gâ‚‚-Checkpoint of the Cell Cycle Resulting in Gâ‚‚-Arrest and Mitochondria-Dependent Apoptosis in Human Acute Leukemia Jurkat T Cells. J Microbiol Biotechnol. 2016;26:287-94 pubmed publisher
    ..Under these conditions, apoptotic events, including upregulation of Bak and PUMA levels, Bak activation, mitochondrial membrane potential (Δψm) loss, activation of caspase-9, -8, and -3, ..
  20. Bai J, Jie H, Wei S, Wang S, Guo H, Tang Q. GART mediates the renewal of intestinal epithelial barrier via p38/p53/PUMA cascade in colitis. Apoptosis. 2016;21:1386-1397 pubmed
    ..kinase (MAPK) pathway, following with the dys-regulation of p53 and p53 up-regulated modulator of apoptosis (PUMA)...
  21. Riedel C, Lehmann B, Broich K, Sudhop T. [Improving drug licensing for children and adolescents : Position paper from the More Medicines for Minors Symposion 8 June 2015 in Bonn]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2016;59:1587-1592 pubmed
    ..In order to do so, the regulation provides for paediatric use marketing authorisations (PUMA) for previously authorised products no longer covered by intellectual property rights and also grants holders of ..
  22. Rojas Valencia L, Velez Pardo C, Jimenez Del Rio M. Metal chelator TPEN selectively induces apoptosis in K562 cells through reactive oxygen species signaling mechanism: implications for chronic myeloid leukemia. Biometals. 2017;30:405-421 pubmed publisher
    ..K562 cells via a molecular cascade involving H2O2 ≫ JNK, NF-κB > c-JUN, P73 > PUMA, BAX > loss of ΔΨm > CASPASE-3 > nuclei/DNA fragmentation...
  23. Wang Y, Gu X, Li W, Zhang Q, Zhang C. PAK1 overexpression promotes cell proliferation in cutaneous T cell lymphoma via suppression of PUMA and p21. J Dermatol Sci. 2018;90:60-67 pubmed publisher
    ..Moreover, the mRNA and protein expression of PUMA (BBC3) and p21 (CDKN1A) were increased in PAK1-silenced Hut 78 and HH cells...
  24. Wu B, Guo B, Kang J, Deng X, Fan Y, Zhang X, et al. Downregulation of Smurf2 ubiquitin ligase in pancreatic cancer cells reversed TGF-?-induced tumor formation. Tumour Biol. 2016;: pubmed
    ..the relationship between the alternate TGF-? signaling pathways: TGF-?/PI3K/Akt/?-catenin and TGF-?/Smad2/3/FoxO1/PUMA and Smurf2...
  25. Singh A, Yashavarddhan M, Kalita B, Ranjan R, Bajaj S, Prakash H, et al. Podophyllotoxin and Rutin Modulates Ionizing Radiation-Induced Oxidative Stress and Apoptotic Cell Death in Mice Bone Marrow and Spleen. Front Immunol. 2017;8:183 pubmed publisher
    ..However, proapoptotic proteins (Puma, Bax, Bak, Caspase-3, and Caspase-7) were significantly declined in this group...
  26. Skeríková A, Brabec J, Kuchta R, Jimenez J, Garcia H, Scholz T. Is the human-infecting Diphyllobothrium pacificum a valid species or just a South American population of the holarctic fish broad tapeworm, D. latum?. Am J Trop Med Hyg. 2006;75:307-10 pubmed
    ..0-98.0% and 98.2-99.9%, respectively. Phylogenetic trees constructed from ITS2 sequences show a markedly distant position of D. pacificum from other species analyzed and also indicate the possible paraphyly of Spirometra...
  27. Zhang G, Park M, Mitchell C, Walker T, Hamed H, Studer E, et al. Multiple cyclin kinase inhibitors promote bile acid-induced apoptosis and autophagy in primary hepatocytes via p53-CD95-dependent signaling. J Biol Chem. 2008;283:24343-58 pubmed publisher
    ..Overexpression of p21 suppressed MDM2, elevated p53 levels, and enhanced CD95, BAX, NOXA, and PUMA expression; knockdown of BAX/NOXA/PUMA reduced CDK inhibitor-stimulated cell killing...
  28. Bu Y, Li X, He Y, Huang C, Shen Y, Cao Y, et al. A phosphomimetic mutant of RelA/p65 at Ser536 induces apoptosis and senescence: An implication for tumor-suppressive role of Ser536 phosphorylation. Int J Cancer. 2016;138:1186-98 pubmed publisher
    ..dramatic apoptosis through affecting expression of a wide range of cell death/survival genes, such as Bim, Puma, Noxa, Bcl-2 and survivin...
  29. Feinberg K, Kolaj A, Wu C, Grinshtein N, Krieger J, Moran M, et al. A neuroprotective agent that inactivates prodegenerative TrkA and preserves mitochondria. J Cell Biol. 2017;216:3655-3675 pubmed publisher
    ..involving unliganded TrkA and transcriptional regulation of the proapoptotic BH3 family members BimEL, Harakiri,and Puma, culminating in preservation of mitochondria in the degenerative setting...
  30. Lai X, Deng Z, Guo H, Zhu X, Tu W. HP1? is highly expressed in glioma cells and facilitates cell proliferation and survival. Cancer Biomark. 2017;20:453-460 pubmed publisher
    ..Furthermore, we find that HP1? and H3K9me3 are enriched in the FAS and PUMA promoters, which suggests that upregulated HP1? and H3K9me3 prevent apoptosis by suppressing apoptotic activators...
  31. Kurtulus S, Sholl A, Toe J, Tripathi P, Raynor J, Li K, et al. Bim controls IL-15 availability and limits engagement of multiple BH3-only proteins. Cell Death Differ. 2015;22:174-84 pubmed publisher
    ..facilitated the elimination of cells with less memory potential via the additional pro-apoptotic molecules Noxa and Puma. Combined, these data show that Bim controls memory development by limiting the survival of pre-memory effector ..
  32. Shinderman Maman E, Cohen K, Weingarten C, Nabriski D, Twito O, Baraf L, et al. The thyroid hormone-αvβ3 integrin axis in ovarian cancer: regulation of gene transcription and MAPK-dependent proliferation. Oncogene. 2016;35:1977-87 pubmed publisher
    ..reduced the expression of genes that inhibit cell cycle (p21, p16), promote mitochondrial apoptosis (Nix, PUMA) and tumor suppression (GDF-15, IGFBP-6), particularly in cells with high integrin expression...
  33. Hendrickx M. Further records of species of Gennadas (Crustacea, Decapoda, Dendrobranchiata, Benthesicymidae) in the Mexican Pacific. Zootaxa. 2015;3980:417-26 pubmed publisher
    ..material of species of Gennadas was collected off western Mexico during the TALUD survey aboard the R/V "El Puma"...
  34. Gu Q, Zhang Z, Cano Ortiz L, Franco A, Haussinger D, Munk C. Feline Immunodeficiency Virus Vif N-Terminal Residues Selectively Counteract Feline APOBEC3s. J Virol. 2016;90:10545-10557 pubmed publisher
    ..are conserved in several FIV lineages of domestic cat and nondomestic cats, while being absent in FIV Vif from puma. Our findings provide important insights for future experiments describing the FIV Vif interaction with feline ..
  35. Yang H, Xie Y, Yang D, Ren D. Oxidative stress-induced apoptosis in granulosa cells involves JNK, p53 and Puma. Oncotarget. 2017;8:25310-25322 pubmed publisher
    ..H2O2 induced an increase in Bax, Bak and Puma, and a decrease in anti-apoptotic molecules such as Bcl-2, Bcl-xL and Mcl-1...
  36. Kim W, Bhatia S, Elliott D, Agholme L, Kågedal K, McCann H, et al. Increased ATP-binding cassette transporter A1 expression in Alzheimer's disease hippocampal neurons. J Alzheimers Dis. 2010;21:193-205 pubmed publisher
    ..The increased hippocampal ABCA1 expression was associated with increased APOE and PUMA gene expression, implying an association with neuronal stress...
  37. Chen T, Yang P, Wang H, He Z. Silence of long noncoding RNA PANDAR switches low-dose curcumin-induced senescence to apoptosis in colorectal cancer cells. Onco Targets Ther. 2017;10:483-491 pubmed publisher
    ..cells increased apoptosis and greatly attenuated senescence possibly by stimulating the expression of PUMA. Together, these findings indicate that knockdown of lncRNA PANDAR switches curcumin-induced senescence to ..
  38. Zhang L, Xie D, Chen X, Hughes M, Jiang G, Lu Z, et al. p53 Mediates Colistin-Induced Autophagy and Apoptosis in PC-12 Cells. Antimicrob Agents Chemother. 2016;60:5294-301 pubmed publisher
    ..proteins involved in autophagy and apoptosis, including LC3-II/I, p53, DRAM (damage-regulated autophagy modulator), PUMA (p53 upregulated modulator of apoptosis), Bax, p-AMPK (activated form of AMP-activated protein kinase), and caspase-..
  39. Hua W, Qi J, Cai Q, Carnahan E, Ayala Ramirez M, Li L, et al. HDAC8 regulates long-term hematopoietic stem-cell maintenance under stress by modulating p53 activity. Blood. 2017;130:2619-2630 pubmed publisher
    ..of p53 reversed the increased apoptosis and elevated expression of proapoptotic targets Noxa and Puma seen in Hdac8-deleted LT-HSCs...
  40. Belkacemi L, Atkins J, Yang L, Gadgil P, Sater A, Chow D, et al. Phosphaplatin Anti-tumor Effect Enhanced by Liposomes Partly via an Up-regulation of PEDF in Breast Cancer. Anticancer Res. 2018;38:623-646 pubmed
    ..In vitro, RRD4 induced 4T1 apoptosis through up-regulation of FAS, BAX, and PUMA, and down-regulation of BCL2. RRD4 facilitates a FAS-intrinsic signaling mechanism...
  41. Fonseca G, Palacios R. An unusual case of predation: dog pack or cougar attack?. J Forensic Sci. 2013;58:224-7 pubmed publisher
    ..Because of the unusual characteristics of the wounds and the initial hypothesis made by local authorities of a cougar attack, habits and specific patterns of both dog pack and cougar predation on humans are discussed. ..
  42. Yu H, Shin J, Yang I, Won D, Ahn C, Kwon H, et al. Apoptosis induced by caffeic acid phenethyl ester in human oral cancer cell lines: Involvement of Puma and Bax activation. Arch Oral Biol. 2017;84:94-99 pubmed publisher
    ..CAPE also significantly increased Puma expression and interestingly Puma and Bax were co-localized...
  43. Li H, Liu L, Chang H, Zou Z, Xing D. Downregulation of MCL-1 and upregulation of PUMA using mTOR inhibitors enhance antitumor efficacy of BH3 mimetics in triple-negative breast cancer. Cell Death Dis. 2018;9:137 pubmed publisher
    ..revealed that mTOR inhibitors induced the suppression of MCL-1; concomitantly, the expression level of PUMA was significantly upregulated in a FOXO3a-dependent manner...
  44. Khandanpour C, Phelan J, Vassen L, Schütte J, Chen R, Horman S, et al. Growth factor independence 1 antagonizes a p53-induced DNA damage response pathway in lymphoblastic leukemia. Cancer Cell. 2013;23:200-14 pubmed publisher
    ..Gfi1 restricts p53 activity and expression of proapoptotic p53 targets such as Bax, Noxa (Pmaip1), and Puma (Bbc3)...
  45. Stephenson N, Swift P, Moeller R, Worth S, Foley J. Feline infectious peritonitis in a mountain lion (Puma concolor), California, USA. J Wildl Dis. 2013;49:408-12 pubmed publisher
    ..In May 2010, a malnourished young adult male mountain lion (Puma concolor) from Kern County, California, USA was euthanized because of concern for public safety, and a postmortem ..
  46. Lei Y, Li J, Jiang J, Li X, Chen D. [Expression and clinical significance of PUMA gene in salivary adenoid cystic carcinoma]. Shanghai Kou Qiang Yi Xue. 2016;25:314-6 pubmed
    To explore the expression of p53 up-regulated modulator of apoptosis (PUMA) gene in salivary adenoid cystic carcinoma (SACC) and its clinical significance...
  47. Kojima K, Maeda A, Yoshimura M, Nishida Y, Kimura S. The pathophysiological significance of PPM1D and therapeutic targeting of PPM1D-mediated signaling by GSK2830371 in mantle cell lymphoma. Oncotarget. 2016;7:69625-69637 pubmed publisher
    ..GSK2830371 increased the levels of total and Ser15-phosphorylated p53, and p53 targets p21 and PUMA. GSK2830371 and the MDM2 inhibitor Nutlin-3a acted synergistically in p53 wild-type cells...
  48. Lee H, Lee S, Shin Y, Cho M, Kang H, Cho H. Anti-Cancer Effect of Quercetin in Xenograft Models with EBV-Associated Human Gastric Carcinoma. Molecules. 2016;21: pubmed
    ..In EBV(-)human gastric carcinoma (MKN74), both quercetin and isoliquiritigenin induced the expressions of p53, Bax, and Puma and the cleaved forms of caspase-3 and -9 and Parp at similar levels.
  49. Wang Y, Compton C, Rankin G, Cutler S, Rojanasakul Y, Tu Y, et al. 3-Hydroxyterphenyllin, a natural fungal metabolite, induces apoptosis and S phase arrest in human ovarian carcinoma cells. Int J Oncol. 2017;50:1392-1402 pubmed publisher
    ..through decreasing the protein levels of Bcl2, Bcl-xL and procaspase-9 and increasing the protein level of Puma. The induction of DR5 and DR4 indicated that the extrinsic apoptotic pathway was also activated...
  50. Wei L, Leibowitz B, Wang X, Epperly M, Greenberger J, Zhang L, et al. Inhibition of CDK4/6 protects against radiation-induced intestinal injury in mice. J Clin Invest. 2016;126:4076-4087 pubmed publisher
    ..inhibited radiation-induced p53 activation, which blocked p53-upregulated modulator of apoptosis-dependent (PUMA-dependent) apoptosis without affecting p21-dependent suppression of DNA damage accumulation, with a repair bias ..
  51. Wang Y, Liu Y, Hu C, Ni X, Huang X. Tumor necrosis factor ?-induced protein 8-like 1 promotes apoptosis by regulating B-cell leukemia/lymphoma-2 family proteins in RAW264.7 cells. Oncol Lett. 2016;12:3506-3512 pubmed
    ..Bcl)-2 associated X protein (Bax), Bcl-2 interacting killer (Bik) and p53 upregulated modulator of apoptosis (Puma), and activate the mitogen activated protein kinases (MAPKs) signaling pathway...
  52. Capiglioni A, Lorenzetti F, Quiroga A, Parody J, Ronco M, Pisani G, et al. Attenuation of liver cancer development by oral glycerol supplementation in the rat. Eur J Nutr. 2018;57:1215-1224 pubmed publisher
    ..Besides, apoptosis was enhanced in IPGly animals, given by an increment of Bax/Bcl-2 ratio, Bad and PUMA mitochondrial expression, a concomitant increase in cytochrome c release and caspase-3 activation...
  53. Kasper C, Schneider A, Oliveira T. Home range and density of three sympatric felids in the Southern Atlantic Forest, Brazil. Braz J Biol. 2016;76:228-32 pubmed publisher
    ..minimal population densities of Southern tiger cat (Leopardus guttulus), margay (Lepardus wiedii) and jaguarundi (Puma yagouaroundi) were estimated between 2005 and 2006 in Taquari Valley, near the southern edge of the Atlantic ..
  54. Du W, Fang L, Yang W, Wu N, Awan F, Yang Z, et al. Induction of tumor apoptosis through a circular RNA enhancing Foxo3 activity. Cell Death Differ. 2017;24:357-370 pubmed publisher
    ..As a result, cell apoptosis was induced by upregulation of the Foxo3 downstream target PUMA.
  55. Pronsato L, Milanesi L, Vasconsuelo A, La Colla A. Testosterone modulates FoxO3a and p53-related genes to protect C2C12 skeletal muscle cells against apoptosis. Steroids. 2017;124:35-45 pubmed publisher
    ..We detected the upregulation of the proapoptotic genes Puma, PERP and Bim, and MDM2 in response to H2O2 at different periods of the apoptotic process, ..
  56. Hong S, Marotte H, Courbon G, Firestein G, Boulanger P, Miossec P. PUMA gene delivery to synoviocytes reduces inflammation and degeneration of arthritic joints. Nat Commun. 2017;8:146 pubmed publisher
    ..Delivery of the pro-apoptotic gene PUMA to FLS via human adenovirus type 5 (HAdV5) vectors has been tested as a therapeutic approach, but efficiency is ..
  57. Foster G, Kinsella J, Sheppard B, Cunningham M. Transmammary infection of free-ranging Florida panther neonates by Alaria marcianae (Trematoda: Diplostomatidae). J Parasitol. 2009;95:238-9 pubmed publisher
    Two freshly-dead female Florida panther (FP) neonates, Puma concolor couguar (=Puma concolor coryi), an 11-day-old and a 17-day-old, were collected in the Florida Panther National Wildlife Refuge (26 degrees 14'N, 81 degrees 36'W), ..
  58. Pietsch S, Tütken T. Oxygen isotope composition of North American bobcat (Lynx rufus) and puma (Puma concolor) bone phosphate: implications for provenance and climate reconstruction. Isotopes Environ Health Stud. 2016;52:164-84 pubmed publisher
    ..Here we analysed ?(18)Op of 106 North American puma and bobcat bones of known geographic origin to establish the first ?(18)Op-?(18)Ow regression for feline carnivores:..
  59. Cui X, Shan X, Qian J, Ji Q, Wang L, Wang X, et al. The suppressor of cytokine signaling SOCS1 promotes apoptosis of intestinal epithelial cells via p53 signaling in Crohn's disease. Exp Mol Pathol. 2016;101:1-11 pubmed publisher
    ..The results showed that the expression of SOCS1 increased in CD patients, and the expression of SOCS1, p-p53 and PUMA increased in the mouse TNBS induced colitis model...
  60. Liu B, Sun R, Luo H, Liu X, Jiang M, Yuan C, et al. Both intrinsic and extrinsic apoptotic pathways are involved in Toll-like receptor 4 (TLR4)-induced cell death in monocytic THP-1 cells. Immunobiology. 2017;222:198-205 pubmed publisher
    ..activation down-regulated the anti-apoptotic protein bcl-2, and up-regulated the pro-apoptotic proteins Noxa and Puma, suggesting that mitochondrial apoptotic pathway was also involved in LPS-induced cell death...
  61. Chen T, Siow K, Ng P, Majlis B. Enhancing the biocompatibility of the polyurethane methacrylate and off-stoichiometry thiol-ene polymers by argon and nitrogen plasma treatment. Mater Sci Eng C Mater Biol Appl. 2017;79:613-621 pubmed publisher
    ..e. polyurethane methacrylate (PUMA) and off-stoichiometry thiol-ene (OSTE-80) polymer by Ar and N2 plasma treatment...
  62. Zhou Z, Zhou L, Jiang F, Zeng B, Wei C, Zhao W, et al. Downregulation of miR-222 Induces Apoptosis and Cellular Migration in Adenoid Cystic Carcinoma Cells. Oncol Res. 2017;25:207-214 pubmed publisher
    Previous studies have shown that miR-222 targets the p53 upregulated modulator of apoptosis (PUMA) to regulate cell biological behavior in some human malignancies...
  63. Rahman F, Ali A, Khan I, Duong H, Guo R, Wang H, et al. Novel phenylenediamine bridged mixed ligands dimetallic square planner Pt(II) complex inhibits MMPs expression via p53 and caspase-dependent signaling and suppress cancer metastasis and invasion. Eur J Med Chem. 2017;125:1064-1075 pubmed publisher
    ..Mechanistically, it enhanced p53 protein expression and regulated p53-dependent genes expression such as p21, PUMA, MYC and hTERT. The TUNEL assay showed that L-Pt-Py induced cell death in cancer cells...
  64. Lee J, Malmberg J, Wood B, Hladky S, Troyer R, Roelke M, et al. Feline Immunodeficiency Virus Cross-Species Transmission: Implications for Emergence of New Lentiviral Infections. J Virol. 2017;91: pubmed publisher
    ..We previously reported natural cross-species transmission of a subtype of feline immunodeficiency virus, puma lentivirus A (PLVA), between bobcats (Lynx rufus) and mountain lions (Puma concolor) for a small ..
  65. Xu T, Yuan Y, Xiao D. The clinical relationship between the slug-mediated Puma/p53 signaling pathway and radiotherapy resistance in nasopharyngeal carcinoma. Eur Rev Med Pharmacol Sci. 2017;21:953-958 pubmed
    To explore the clinical relationship between the Slug-mediated Puma/p53 signaling pathway and radiotherapy resistance in nasopharyngeal carcinoma...
  66. Garufi A, Pistritto G, Baldari S, Toietta G, Cirone M, D Orazi G. p53-Dependent PUMA to DRAM antagonistic interplay as a key molecular switch in cell-fate decision in normal/high glucose conditions. J Exp Clin Cancer Res. 2017;36:126 pubmed publisher
    ..switching cancer cells in high glucose (HG) impairs p53 apoptotic function and the transcription of target gene PUMA. Here we report that, in response to drug adriamycin (ADR) in HG, p53 efficiently induced the expression of DRAM (..
  67. Matsumoto T, Uchiumi T, Monji K, Yagi M, Setoyama D, Amamoto R, et al. Doxycycline induces apoptosis via ER stress selectively to cells with a cancer stem cell-like properties: importance of stem cell plasticity. Oncogenesis. 2017;6:397 pubmed publisher
    ..factor 4 (ATF4) mediated expression of ER stress response and led to p53-upregulated modulator of apoptosis (PUMA)-dependent apoptosis only in the cancer stem-like cells...
  68. Li C, Li Q, Cai Y, He Y, Lan X, Wang W, et al. Overexpression of angiopoietin 2 promotes the formation of oral squamous cell carcinoma by increasing epithelial-mesenchymal transition-induced angiogenesis. Cancer Gene Ther. 2016;23:295-302 pubmed publisher
    ..ANG2 resulted in changes in the expression of tumor formation-related proteins including vimentin, E-cadherin, Bim, PUMA, Bcl-2, Bax, Cyclin D1, PCNA and CD31...
  69. Horikawa I, Park K, Isogaya K, Hiyoshi Y, Li H, Anami K, et al. ?133p53 represses p53-inducible senescence genes and enhances the generation of human induced pluripotent stem cells. Cell Death Differ. 2017;24:1017-1028 pubmed publisher
    ..mediate cellular senescence (p21WAF1, miR-34a, PAI-1 and IGFBP7), but not those for apoptosis (BAX and PUMA) and DNA damage repair (p53R2), were downregulated in iPSC and ESC...
  70. Olgar Y, Ozdemir S, Turan B. Induction of endoplasmic reticulum stress and changes in expression levels of Zn2+-transporters in hypertrophic rat heart. Mol Cell Biochem. 2018;440:209-219 pubmed publisher
    ..expression levels of apoptotic status marker proteins such as the serine kinase GSK-3?, Bax-to-Bcl-2 ratio, and PUMA in TAC-group in comparison to SHAM-group...
  71. Glab J, Doerflinger M, Nedeva C, Jose I, Mbogo G, Paton J, et al. DR5 and caspase-8 are dispensable in ER stress-induced apoptosis. Cell Death Differ. 2017;24:944-950 pubmed publisher
    ..in ER stress-induced cell death, particularly the role of the pro-apoptotic BH3-only BCL-2 family members, BIM and PUMA. However, a recent report suggested a central role for the death receptor, DR5, activated in a ligand-independent ..
  72. Yu C, Jerry Teng C, Hung P, Cheng C, Hsu S, Hwang G, et al. Ovatodiolide isolated from Anisomeles indica induces cell cycle G2/M arrest and apoptosis via a ROS-dependent ATM/ATR signaling pathways. Eur J Pharmacol. 2018;819:16-29 pubmed publisher
    ..ovatodiolide-triggered apoptosis was through both intrinsic and extrinsic pathways characterized by the elevating PUMA, Bax, and DR5 proteins, decreasing Bcl-2 and Mcl-1, and activating caspase-8, caspase-9 and caspase-3...
  73. Yang W, Hosford S, Traphagen N, Shee K, Demidenko E, Liu S, et al. Autophagy promotes escape from phosphatidylinositol 3-kinase inhibition in estrogen receptor-positive breast cancer. FASEB J. 2017;: pubmed publisher
    ..induced mitochondrial membrane depolarization, which required the BH3-only proapoptotic proteins Bim and PUMA. Treatment with GDC-0941, CQ, or the combination, significantly suppressed the growth of ER+ breast ..
  74. Gomez Puerto M, Folkerts H, Wierenga A, Schepers K, Schuringa J, Coffer P, et al. Autophagy Proteins ATG5 and ATG7 Are Essential for the Maintenance of Human CD34(+) Hematopoietic Stem-Progenitor Cells. Stem Cells. 2016;34:1651-63 pubmed publisher
    ..This is accompanied by increased expression of p53, proapoptotic genes BAX and PUMA, and the cell cycle inhibitor p21, as well as increased levels of cleaved caspase-3 and reactive oxygen species...
  75. Deeks E. Neratinib: First Global Approval. Drugs. 2017;77:1695-1704 pubmed publisher
    ..The drug originally arose from research by Wyeth (now Pfizer) and is now being developed by Puma Biotechnology primarily for the treatment of HER2-positive (HER+) breast cancer...
  76. Liu T, Chen X, Li T, Li X, Lyu Y, Fan X, et al. Histone methyltransferase SETDB1 maintains survival of mouse spermatogonial stem/progenitor cells via PTEN/AKT/FOXO1 pathway. Biochim Biophys Acta Gene Regul Mech. 2017;1860:1094-1102 pubmed publisher
    ..and coordinated with AKT to regulate FOXO1 activity and expression of the downstream target genes Bim and Puma. Among the SETDB1-bound genes, the H3K9me3 levels on the promoter regions of Bim and Pten decreased in Setdb1-KD ..
  77. Wang A, Wang W, Chen Y, Ma F, Wei X, Bi Y. Deguelin induces PUMA-mediated apoptosis and promotes sensitivity of lung cancer cells (LCCs) to doxorubicin (Dox). Mol Cell Biochem. 2018;442:177-186 pubmed publisher
    ..research, it was revealed that deguelin induced cell death of lung cancer cells (LCCs) by triggering expression of PUMA. Deguelin triggered PUMA induction independently of p53 via suppression of PI3K/AKT pathway, therefore stimulating ..
  78. Ironside K, Mattson D, Theimer T, Jansen B, Holton B, Arundel T, et al. Quantifying animal movement for caching foragers: the path identification index (PII) and cougars, Puma concolor. Mov Ecol. 2017;5:24 pubmed publisher
  79. Wolfe L, Miller M. Suspected secondary thiafentanil intoxication in a captive mountain lion (Puma concolor). J Wildl Dis. 2005;41:829-33 pubmed
    Inadvertent ingestion of thiafentanil oxalate by a captive adult female mountain lion (Puma concolor) caused a prolonged clinical syndrome that included sedation and depression, muscle tension, and myopathy that was incompletely ..
  80. Wheeler D, Waller L, Biek R. Spatial analysis of feline immunodeficiency virus infection in cougars. Spat Spatiotemporal Epidemiol. 2010;1:151-61 pubmed publisher
    The cougar (Puma concolor) is a large predatory feline found widely in the Americas that is susceptible to feline immunodeficiency virus (FIV), a fast-evolving lentivirus found in wild feline species that is analogous to simian ..
  81. Andreasen A, Stewart K, Longland W, Beckmann J, Forister M. Identification of source-sink dynamics in mountain lions of the Great Basin. Mol Ecol. 2012;21:5689-701 pubmed publisher
    ..We analysed thirteen microsatellite loci for 739 mountain lions (Puma concolor) using muscle tissue samples from individuals in the Great Basin throughout Nevada and the Sierra Nevada ..
  82. Fogha J, Marekha B, De Giorgi M, Voisin Chiret A, Rault S, Bureau R, et al. Toward Understanding Mcl-1 Promiscuous and Specific Binding Mode. J Chem Inf Model. 2017;: pubmed publisher
    ..These protein-protein interactions exhibit some selectivity: Mcl-1 binds specifically to Noxa, whereas Bim and Puma bind strongly to all anti-apoptotic proteins...
  83. Festa Bianchet M, Coulson T, Gaillard J, Hogg J, Pelletier F. Stochastic predation events and population persistence in bighorn sheep. Proc Biol Sci. 2006;273:1537-43 pubmed
    ..Each population experienced one or two distinct cougar (Puma concolor) predation events leading to population declines...
  84. Jang Y, Kim J, Ko J, Kwon Y. Homocysteine induces PUMA-mediated mitochondrial apoptosis in SH-SY5Y cells. Amino Acids. 2016;48:2559-2569 pubmed
    ..and p53, resulting in the upregulation of their downstream target gene, p53 up-regulated modulator of apoptosis (PUMA)...
  85. Song H, Wei M, Liu W, Shen S, Li J, Wang L. Cisplatin induced apoptosis of ovarian cancer A2780s cells by activation of ERK/p53/PUMA signals. Histol Histopathol. 2018;33:73-79 pubmed publisher
    ..A2780s cells were treated with CDDP (1.5-3 ?g/ml) for 6h, 12h and 24h. Using siRNA targeting P53 and PUMA, and a selective MEK inhibitor, PD98059 to examine the relation between ERK1/2 activation, p53 and PUMA expression ..
  86. Chen G, Fu S, Feng W, Huang B, Xu S, Wang W, et al. AMP010014A09 in Sus Scrofa Encodes an Analog of G Protein-Coupled Receptor 109A, Which Mediates the Anti-Inflammatory Effects of Beta-Hydroxybutyric Acid. Cell Physiol Biochem. 2017;42:1420-1430 pubmed publisher
    ..AMP+ in swine exhibited a high level of homology with HM74A in humans and PUMA-G in mice...
  87. Harford T, Kliment G, Shukla G, Weyman C. The muscle regulatory transcription factor MyoD participates with p53 to directly increase the expression of the pro-apoptotic Bcl2 family member PUMA. Apoptosis. 2017;22:1532-1542 pubmed publisher
    ..previously reported that MyoD is also necessary for the elevated expression of the pro-apoptotic Bcl2 family member PUMA, and the ensuing apoptosis, that occurs in a subset of myoblasts induced to differentiate...
  88. Erdogan S, Villar S, Konig H, Perez W. Papillary architecture of the lingual surface in the puma (Puma concolor). Anat Histol Embryol. 2017;: pubmed publisher
    This research presents the first anatomical description of the tongue and lingual papillae of the mountain lion (puma). The tongues of three adult male pumas were used in this study...
  89. Durden L, Cunningham M, McBride R, Ferree B. Ectoparasites of free-ranging pumas and jaguars in the Paraguayan Chaco. Vet Parasitol. 2006;137:189-93 pubmed
    Ectoparasites were collected from seven puma (Puma concolor) and seven jaguar (Panthera onca) live-captures (each representing six different animals) in the Paraguayan Chaco from 2002 to 2004...
  90. Poss M, Ross H, Rodrigo A, Terwee J, Vandewoude S, Biek R. The molecular biology and evolution of feline immunodeficiency viruses of cougars. Vet Immunol Immunopathol. 2008;123:154-8 pubmed publisher
    ..We studied FIVpco infection of cougars (Puma concolor) as a model for asymptomatic lentivirus infections to understand the mechanisms of host-virus coexistence...
  91. McCubrey J, Lertpiriyapong K, Fitzgerald T, Martelli A, Cocco L, Rakus D, et al. Roles of TP53 in determining therapeutic sensitivity, growth, cellular senescence, invasion and metastasis. Adv Biol Regul. 2017;63:32-48 pubmed publisher
    ..While TP53 has been documented to control the expression of many "classical" genes (e.g., p21Cip-1, PUMA, Bax) by transcriptional mechanisms for quite some time, more recently TP53 has been shown to regulate microRNA (..
  92. Lai X, Deng Z, Guo H, Zhu X, Tu W. HP1? is highly expressed in glioma cells and facilitates cell proliferation and survival. Biochem Biophys Res Commun. 2017;490:415-422 pubmed publisher
    ..Furthermore, we find that HP1? and H3K9me3 are enriched in the FAS and PUMA promoters, which suggests that upregulated HP1? and H3K9me3 contribute to cell survival by suppressing apoptotic ..