Summary: Semidomesticated variety of European polecat much used for hunting RODENTS and/or RABBITS and as a laboratory animal. It is in the subfamily Mustelinae, family MUSTELIDAE.

Top Publications

  1. Maines T, Chen L, Van Hoeven N, Tumpey T, Blixt O, Belser J, et al. Effect of receptor binding domain mutations on receptor binding and transmissibility of avian influenza H5N1 viruses. Virology. 2011;413:139-47 pubmed publisher
    ..the H5 HA, the rescued mutant viruses displayed reduced replication in vitro and delayed peak virus shedding in ferrets. An improvement in transmission efficiency was not observed with any of the mutants compared to the parental ..
  2. Meunier I, Embury Hyatt C, Stebner S, Gray M, Bastien N, Li Y, et al. Virulence differences of closely related pandemic 2009 H1N1 isolates correlate with increased inflammatory responses in ferrets. Virology. 2012;422:125-31 pubmed publisher
    ..Mexican isolate A/Mexico/InDRE4487/2009 and a mild Canadian isolate A/Canada-AB/RV1532/2009 was compared in ferrets. These viruses differed at nine residues, none of which has been previously identified as virulence factor...
  3. Maines T, Belser J, Gustin K, Van Hoeven N, Zeng H, Svitek N, et al. Local innate immune responses and influenza virus transmission and virulence in ferrets. J Infect Dis. 2012;205:474-85 pubmed publisher
    Host innate immunity is the first line of defense against invading pathogens, including influenza viruses. Ferrets are well recognized as the best model of influenza virus pathogenesis and transmission, but little is known about the ..
  4. Hartley D, Vongpaisal T, Xu J, Shepherd R, King A, Isaiah A. Bilateral cochlear implantation in the ferret: a novel animal model for behavioral studies. J Neurosci Methods. 2010;190:214-28 pubmed publisher
    ..Although ferrets are ideally suited to psychophysical and physiological assessments of binaural hearing, cochlear implantation has ..
  5. Min J, Chen G, Santos C, Lamirande E, Matsuoka Y, Subbarao K. Classical swine H1N1 influenza viruses confer cross protection from swine-origin 2009 pandemic H1N1 influenza virus infection in mice and ferrets. Virology. 2010;408:128-133 pubmed publisher
    ..elicited antibodies against the CA/7/09 virus and provided complete protection from challenge with this virus in ferrets; the response in mice was variable and conferred partial protection...
  6. Bajo V, Nodal F, Moore D, King A. The descending corticocollicular pathway mediates learning-induced auditory plasticity. Nat Neurosci. 2010;13:253-60 pubmed publisher
    ..We examined the role of these neurons in experience-dependent recalibration of sound localization in adult ferrets by selectively killing the neurons using chromophore-targeted laser photolysis...
  7. Dahmen J, Keating P, Nodal F, Schulz A, King A. Adaptation to stimulus statistics in the perception and neural representation of auditory space. Neuron. 2010;66:937-48 pubmed publisher
    ..how auditory spatial processing adapts to stimulus statistics by presenting human listeners and anesthetized ferrets with noise sequences in which interaural level differences (ILD) rapidly fluctuated according to a Gaussian ..
  8. Bizley J, Walker K, King A, Schnupp J. Neural ensemble codes for stimulus periodicity in auditory cortex. J Neurosci. 2010;30:5078-91 pubmed publisher
    We measured the responses of neurons in auditory cortex of male and female ferrets to artificial vowels of varying fundamental frequency (f(0)), or periodicity, and compared these with the performance of animals trained to discriminate ..
  9. Bizley J, King A. Visual influences on ferret auditory cortex. Hear Res. 2009;258:55-63 pubmed publisher
    ..Single-neuron recording studies in ferrets have shown that each of auditory fields that have been characterized using physiological and anatomical criteria ..

More Information

Publications127 found, 100 shown here

  1. Nodal F, Keating P, King A. Chronic detachable headphones for acoustic stimulation in freely moving animals. J Neurosci Methods. 2010;189:44-50 pubmed publisher
    ..We have designed a system for closed-field stimulus presentation in freely moving ferrets, which comprises lightweight, adjustable headphones that can be consistently positioned over the ears via a small,..
  2. Memoli M, Davis A, Proudfoot K, Chertow D, Hrabal R, Bristol T, et al. Multidrug-resistant 2009 pandemic influenza A(H1N1) viruses maintain fitness and transmissibility in ferrets. J Infect Dis. 2011;203:348-57 pubmed publisher
    ..infected with pandemic influenza H1N1 were tested for viral fitness, pathogenicity, and transmissibility in ferrets. The pretreatment wild-type viruses and posttreatment resistant viruses containing the H275Y mutation all ..
  3. Berkes P, Orbán G, Lengyel M, Fiser J. Spontaneous cortical activity reveals hallmarks of an optimal internal model of the environment. Science. 2011;331:83-7 pubmed publisher
    ..To test this prediction, we analyzed visual cortical activity of awake ferrets during development...
  4. Kitano M, Itoh Y, Kodama M, Ishigaki H, Nakayama M, Ishida H, et al. Efficacy of single intravenous injection of peramivir against influenza B virus infection in ferrets and cynomolgus macaques. Antimicrob Agents Chemother. 2011;55:4961-70 pubmed publisher
    We evaluated the efficacy of a single intravenous dose peramivir for treatment of influenza B virus infection in ferrets and cynomolgus macaques in the present study...
  5. Krigsfeld G, Sanzari J, Kennedy A. The effects of proton radiation on the prothrombin and partial thromboplastin times of irradiated ferrets. Int J Radiat Biol. 2012;88:327-34 pubmed publisher
    To determine whether proton radiation affects coagulation. Ferrets were exposed to solar particle event-like proton radiation at doses of 0, 25, 100, or 200 centigray (cGy), and dose rates of 50 cGy/minute (high dose rate or HDR) or 50 ..
  6. Ku K, Park E, Yum J, Kim H, Kang Y, Kim J, et al. Transmissibility of novel H7N9 and H9N2 avian influenza viruses between chickens and ferrets. Virology. 2014;450-451:316-23 pubmed publisher
    Previous studies have shown that the H7N9 avian influenza virus cannot be transmitted efficiently between ferrets via respiratory droplets...
  7. Friesen R, Koudstaal W, Koldijk M, Weverling G, Brakenhoff J, Lenting P, et al. New class of monoclonal antibodies against severe influenza: prophylactic and therapeutic efficacy in ferrets. PLoS ONE. 2010;5:e9106 pubmed publisher
    ..of the human monoclonal antibody CR6261 against lethal challenge with the highly pathogenic avian H5N1 virus in ferrets, the optimal model of human influenza infection...
  8. Gustin K, Maines T, Belser J, Van Hoeven N, Lu X, Dong L, et al. Comparative immunogenicity and cross-clade protective efficacy of mammalian cell-grown inactivated and live attenuated H5N1 reassortant vaccines in ferrets. J Infect Dis. 2011;204:1491-9 pubmed publisher
    ..We report a comparative evaluation in ferrets of the immunogenicity and cross-protective efficacy of isogenic mammalian cell-grown, live attenuated influenza ..
  9. Baz M, Paskel M, Matsuoka Y, Zengel J, Cheng X, Jin H, et al. Replication and immunogenicity of swine, equine, and avian h3 subtype influenza viruses in mice and ferrets. J Virol. 2013;87:6901-10 pubmed publisher
    ..their kinetics of replication and ability to induce a broadly cross-reactive antibody response in mice and ferrets. The swine and equine viruses replicated well in the upper respiratory tract of mice...
  10. Hartley D, Dahmen J, King A, Schnupp J. Binaural sensitivity changes between cortical on and off responses. J Neurophysiol. 2011;106:30-43 pubmed publisher
    ..We measured the sensitivity of A1 neurons in anesthetized ferrets to 1) interaural level differences (ILDs), using unmodulated broadband noise with varying ILDs and average ..
  11. Lee Y, Lee D, Park J, Yuk S, Kwon J, Nahm S, et al. Experimental infection and natural contact exposure of ferrets with canine influenza virus (H3N2). J Gen Virol. 2013;94:293-7 pubmed publisher
    ..H3N2 CIV replicated efficiently in the respiratory system of inoculated ferrets and caused acute necrotizing bronchioalveolitis and non-suppurative encephalitis...
  12. Smith J, Papania M, Knaus D, Brooks P, Haas D, Mair R, et al. Nebulized live-attenuated influenza vaccine provides protection in ferrets at a reduced dose. Vaccine. 2012;30:3026-33 pubmed publisher
    ..We investigated LAIV vaccination in ferrets using a high efficiency nebulizer designed for nasal delivery...
  13. Scallan C, Tingley D, Lindbloom J, Toomey J, Tucker S. An adenovirus-based vaccine with a double-stranded RNA adjuvant protects mice and ferrets against H5N1 avian influenza in oral delivery models. Clin Vaccine Immunol. 2013;20:85-94 pubmed publisher
    ..Immunized ferrets and mice were protected upon lethal challenge...
  14. Zaraket H, Bridges O, Duan S, Baranovich T, Yoon S, Reed M, et al. Increased acid stability of the hemagglutinin protein enhances H5N1 influenza virus growth in the upper respiratory tract but is insufficient for transmission in ferrets. J Virol. 2013;87:9911-22 pubmed publisher
    ..Wild-type and HA2-K58I viruses promoted similar levels of morbidity and mortality in C57BL/6J mice and ferrets, and neither virus transmitted efficiently to naive contact cage-mate ferrets...
  15. Long J, Vela E, Stark G, Jones K, Miller S, Bigger J. Early indicators of disease in ferrets infected with a high dose of avian influenza H5N1. Sci Rep. 2012;2:972 pubmed publisher
    ..b>Ferrets are susceptible to infection with avian and human influenza A and B viruses and have been widely used as a model ..
  16. Van Der Vries E, Stittelaar K, van Amerongen G, Veldhuis Kroeze E, de Waal L, Fraaij P, et al. Prolonged influenza virus shedding and emergence of antiviral resistance in immunocompromised patients and ferrets. PLoS Pathog. 2013;9:e1003343 pubmed publisher
    ..difficulties in studying antiviral efficacy in immunocompromised patients, we have infected immunocompromised ferrets with either wild-type, or oseltamivir-resistant (H275Y) 2009 pandemic virus...
  17. Suguitan A, Cheng X, Wang W, Wang S, Jin H, Lu S. Influenza H5 hemagglutinin DNA primes the antibody response elicited by the live attenuated influenza A/Vietnam/1203/2004 vaccine in ferrets. PLoS ONE. 2011;6:e21942 pubmed publisher
    ..strategy, we have evaluated different prime-boost regimens using inactivated, DNA and live attenuated vaccines in ferrets. Live attenuated influenza A/Vietnam/1203/2004 (H5N1) candidate vaccine (LAIV, VN04 ca) primed ferrets ..
  18. Plourde J, Pyles J, Layton R, Vaughan S, Tipper J, Harrod K. Neurovirulence of H5N1 infection in ferrets is mediated by multifocal replication in distinct permissive neuronal cell regions. PLoS ONE. 2012;7:e46605 pubmed publisher
    ..We elucidate the temporal/spatial infection of H5N1 in the brain of ferrets following a low dose, intranasal infection of two HPAI strains of varying neurovirulence and lethality...
  19. Banner D, Kelvin A. The current state of H5N1 vaccines and the use of the ferret model for influenza therapeutic and prophylactic development. J Infect Dev Ctries. 2012;6:465-9 pubmed
    ..and prophylactics, in particular the preparation of viable H5N1 vaccination strategies as well as the use of ferrets in influenza research...
  20. Dimmock N, Dove B, Scott P, Meng B, Taylor I, Cheung L, et al. Cloned defective interfering influenza virus protects ferrets from pandemic 2009 influenza A virus and allows protective immunity to be established. PLoS ONE. 2012;7:e49394 pubmed publisher
    ..2 µg 244 RNA delivered as A/PR/8/34 virus particles protected ferrets from disease caused by pandemic virus A/California/04/09 (A/Cal; H1N1)...
  21. Van Der Vries E, Veldhuis Kroeze E, Stittelaar K, Linster M, Van der Linden A, Schrauwen E, et al. Multidrug resistant 2009 A/H1N1 influenza clinical isolate with a neuraminidase I223R mutation retains its virulence and transmissibility in ferrets. PLoS Pathog. 2011;7:e1002276 pubmed publisher
    ..Both NL/2631-R223 and a recombinant virus with a single I223R change (recNL/602-I223R), transmitted among ferrets by aerosols, despite observed attenuation of recNL/602-I223R in vitro...
  22. Bodewes R, Kreijtz J, van Amerongen G, Hillaire M, Vogelzang van Trierum S, Nieuwkoop N, et al. Infection of the upper respiratory tract with seasonal influenza A(H3N2) virus induces protective immunity in ferrets against infection with A(H1N1)pdm09 virus after intranasal, but not intratracheal, inoculation. J Virol. 2013;87:4293-301 pubmed publisher
    ..Here we show that ferrets acquire protective immunity after infection of the upper respiratory tract with a seasonal influenza A(H3N2) ..
  23. Fisher J, Tyler S, Zhang Y, Lee B, Liu X, Sun X, et al. Bioelectric characterization of epithelia from neonatal CFTR knockout ferrets. Am J Respir Cell Mol Biol. 2013;49:837-44 pubmed publisher
    ..CFTR knockout ferrets manifest many of the phenotypes observed in the human disease, including lung infections, pancreatic disease and ..
  24. Zhang Q, Shi J, Deng G, Guo J, Zeng X, He X, et al. H7N9 influenza viruses are transmissible in ferrets by respiratory droplet. Science. 2013;341:410-4 pubmed publisher
    ..Most importantly, one virus isolated from humans was highly transmissible in ferrets by respiratory droplet...
  25. Chen Z, Zhou H, Kim L, Jin H. The receptor binding specificity of the live attenuated influenza H2 and H6 vaccine viruses contributes to vaccine immunogenicity and protection in ferrets. J Virol. 2012;86:2780-6 pubmed publisher
    ..L226/S228 that preferentially bound to ?2,6-SA receptors replicated efficiently in the upper respiratory tract of ferrets, induced high levels of neutralizing antibody, and conferred a high level of protection against wild-type virus ..
  26. Suguitan A, Matsuoka Y, Lau Y, Santos C, Vogel L, Cheng L, et al. The multibasic cleavage site of the hemagglutinin of highly pathogenic A/Vietnam/1203/2004 (H5N1) avian influenza virus acts as a virulence factor in a host-specific manner in mammals. J Virol. 2012;86:2706-14 pubmed publisher
    ..possessed (H5N1) or lacked (?H5N1) the H5 HA MBS were generated and evaluated for their virulence in BALB/c mice, ferrets, and African green monkeys (AGMs) (Chlorocebus aethiops)...
  27. Richard M, Schrauwen E, de Graaf M, Bestebroer T, Spronken M, van Boheemen S, et al. Limited airborne transmission of H7N9 influenza A virus between ferrets. Nature. 2013;501:560-3 pubmed publisher
    ..associated with human adaptation and transmissibility between mammals, its airborne transmissibility in ferrets is limited, and it is intermediate between that of typical human and avian influenza viruses...
  28. Abed Y, Pizzorno A, Bouhy X, Rhéaume C, Boivin G. Impact of potential permissive neuraminidase mutations on viral fitness of the H275Y oseltamivir-resistant influenza A(H1N1)pdm09 virus in vitro, in mice and in ferrets. J Virol. 2014;88:1652-8 pubmed publisher
    ..Virulence was assessed in C57BL/6 mice, and contact transmission was evaluated in ferrets. The H275Y mutation significantly reduced viral titers during the first 12 to 36 h postinfection (p.i.) in vitro...
  29. Le Sueur C, Bour S, Schaper R. Efficacy and safety of the combination imidacloprid 10 % / moxidectin 1.0 % spot-on (Advocate(®) spot-on for small cats and ferrets) in the treatment of ear mite infection (Otodectes cynotis) in ferrets. Parasitol Res. 2011;109 Suppl 1:S149-56 pubmed publisher
    ..0 % spot-on (Advocate(®) spot-on for small cats and ferrets) was tested in 39 ferrets naturally infested with ear mites (Otodectes cynotis)...
  30. Walker K, Bizley J, King A, Schnupp J. Multiplexed and robust representations of sound features in auditory cortex. J Neurosci. 2011;31:14565-76 pubmed publisher
    ..Finally, we observed that formant information is encoded in cortex earlier than pitch information, and we show that this time course matches ferrets' behavioral reaction time differences on a change detection task.
  31. Belser J, Gustin K, Maines T, Pantin Jackwood M, Katz J, Tumpey T. Influenza virus respiratory infection and transmission following ocular inoculation in ferrets. PLoS Pathog. 2012;8:e1002569 pubmed publisher
    ..of human and avian influenza viruses mounted a productive virus infection in the upper respiratory tract of ferrets following ocular inoculation, and were additionally detected in ocular tissue during the acute phase of infection...
  32. Marsh G, De Jong C, Barr J, Tachedjian M, Smith C, Middleton D, et al. Cedar virus: a novel Henipavirus isolated from Australian bats. PLoS Pathog. 2012;8:e1002836 pubmed publisher
    ..Preliminary challenge studies with CedPV in ferrets and guinea pigs, both susceptible to infection and disease with known henipaviruses, confirmed virus replication ..
  33. Layton R, Gigliotti A, Armijo P, Myers L, Knight J, Donart N, et al. Enhanced immunogenicity, mortality protection, and reduced viral brain invasion by alum adjuvant with an H5N1 split-virion vaccine in the ferret. PLoS ONE. 2011;6:e20641 pubmed publisher
    ..b>Ferrets (N?=?118) were vaccinated twice with a split-virion vaccine preparation of A/Vietnam/1203/2004 or saline either ..
  34. Rabinowitz N, Willmore B, Schnupp J, King A. Contrast gain control in auditory cortex. Neuron. 2011;70:1178-91 pubmed publisher
    ..By using contrast gain control to expand or compress the representation of its inputs, the auditory system may be seeking an efficient coding of natural sounds. ..
  35. Pinilla L, Holder B, Abed Y, Boivin G, Beauchemin C. The H275Y neuraminidase mutation of the pandemic A/H1N1 influenza virus lengthens the eclipse phase and reduces viral output of infected cells, potentially compromising fitness in ferrets. J Virol. 2012;86:10651-60 pubmed publisher
    ..In ferrets, however, the mutant strain appears to suffer a delay in its infection of the respiratory tract that allows the ..
  36. Lakdawala S, Lamirande E, Suguitan A, Wang W, Santos C, Vogel L, et al. Eurasian-origin gene segments contribute to the transmissibility, aerosol release, and morphology of the 2009 pandemic H1N1 influenza virus. PLoS Pathog. 2011;7:e1002443 pubmed publisher
    ..All viruses replicated well in the upper respiratory tract of infected ferrets, suggesting that factors other than viral replication are important for the release of influenza virus particles ..
  37. Campagnolo E, Moll M, Tuhacek K, Simeone A, Miller W, Waller K, et al. Concurrent 2009 pandemic influenza A (H1N1) virus infection in ferrets and in a community in Pennsylvania. Zoonoses Public Health. 2013;60:117-24 pubmed publisher
    We report a fall 2010 cluster of pandemic influenza A/H1N1 (pH1N1) infections in pet ferrets in Lehigh Valley region of Pennsylvania. The ferrets were associated with one pet shop...
  38. Imai M, Watanabe T, Hatta M, Das S, Ozawa M, Shinya K, et al. Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets. Nature. 2012;486:420-8 pubmed publisher
    ..The transmissible H5 reassortant virus preferentially recognized human-type receptors, replicated efficiently in ferrets, caused lung lesions and weight loss, but was not highly pathogenic and did not cause mortality...
  39. Xiong X, Coombs P, Martin S, Liu J, Xiao H, McCauley J, et al. Receptor binding by a ferret-transmissible H5 avian influenza virus. Nature. 2013;497:392-6 pubmed publisher
    ..human receptors, and transmissible-mutant-selection experiments have identified a virus that is transmissible in ferrets, the generally accepted experimental model for influenza in humans...
  40. Pascua P, Song M, Kwon H, Lim G, Kim E, Park S, et al. The homologous tripartite viral RNA polymerase of A/swine/Korea/CT1204/2009(H1N2) influenza virus synergistically drives efficient replication and promotes respiratory droplet transmission in ferrets. J Virol. 2013;87:10552-62 pubmed publisher
    We previously reported that influenza A/swine/Korea/1204/2009(H1N2) virus was virulent and transmissible in ferrets in which the respiratory-droplet-transmissible virus (CT-Sw/1204) had acquired simultaneous hemagglutinin (HAD225G) and ..
  41. Belser J, Jayaraman A, Raman R, Pappas C, Zeng H, Cox N, et al. Effect of D222G mutation in the hemagglutinin protein on receptor binding, pathogenesis and transmissibility of the 2009 pandemic H1N1 influenza virus. PLoS ONE. 2011;6:e25091 pubmed publisher
    ..These findings suggest that although the D222G mutation does not influence virus transmission, it may be considered a molecular marker for enhanced replication in certain cell types. ..
  42. Jayaraman A, Chandrasekaran A, Viswanathan K, Raman R, Fox J, Sasisekharan R. Decoding the distribution of glycan receptors for human-adapted influenza A viruses in ferret respiratory tract. PLoS ONE. 2012;7:e27517 pubmed publisher
    b>Ferrets are widely used as animal models for studying influenza A viral pathogenesis and transmissibility...
  43. Meredith M, Keniston L, Allman B. Multisensory dysfunction accompanies crossmodal plasticity following adult hearing impairment. Neuroscience. 2012;214:136-48 pubmed publisher
    ..massive crossmodal cortical reorganization was demonstrated to result from profound hearing loss in adult ferrets (Allman et al., 2009a)...
  44. Cameron M, Kelvin A, Leon A, Cameron C, Ran L, Xu L, et al. Lack of innate interferon responses during SARS coronavirus infection in a vaccination and reinfection ferret model. PLoS ONE. 2012;7:e45842 pubmed publisher
    ..insight into SARS immunopathogenesis and to identify correlates of immune protection during SARS-CoV-challenge in ferrets previously infected with SARS-CoV or immunized with a SARS virus vaccine...
  45. Rockman S, Middleton D, Pearse M, Barr I, Lowther S, Brown L. Control of pandemic (H1N1) 2009 influenza virus infection of ferret lungs by non-adjuvant-containing pandemic and seasonal vaccines. Vaccine. 2012;30:3618-23 pubmed publisher
    ..as did many of the subsequent vaccines, and could not stop infection with the pandemic virus in vaccinated ferrets. Nevertheless, we showed that virus loads in the lungs were greatly diminished in ferrets vaccinated once with an ..
  46. Bizley J, Walker K, King A, Schnupp J. Spectral timbre perception in ferrets: discrimination of artificial vowels under different listening conditions. J Acoust Soc Am. 2013;133:365-76 pubmed publisher
    ..In this study, ferrets were positively conditioned to discriminate artificial vowel sounds in a two-alternative-forced-choice paradigm...
  47. Macinnes H, Zhou Y, Gouveia K, Cromwell J, Lowery K, Layton R, et al. Transmission of aerosolized seasonal H1N1 influenza A to ferrets. PLoS ONE. 2011;6:e24448 pubmed publisher
    ..Recent studies of influenza non-contact transmission between ferrets and guinea pigs have provided insights into the relative transmission efficiencies of pandemic and seasonal ..
  48. Perez D. Public health and biosecurity. H5N1 debates: hung up on the wrong questions. Science. 2012;335:799-801 pubmed publisher
  49. Herfst S, Schrauwen E, Linster M, Chutinimitkul S, de Wit E, Munster V, et al. Airborne transmission of influenza A/H5N1 virus between ferrets. Science. 2012;336:1534-41 pubmed publisher
    ..conditions, we genetically modified A/H5N1 virus by site-directed mutagenesis and subsequent serial passage in ferrets. The genetically modified A/H5N1 virus acquired mutations during passage in ferrets, ultimately becoming airborne ..
  50. Houser K, Katz J, Tumpey T. Seasonal trivalent inactivated influenza vaccine does not protect against newly emerging variants of influenza A (H3N2v) virus in ferrets. J Virol. 2013;87:1261-3 pubmed publisher
    ..Our data demonstrate that the 2011-2012 trivalent inactivated influenza vaccine (TIV) protected ferrets against homologous H3N2 virus challenge but provided minimal to no protection against A(H3N2)v virus...
  51. Gustin K, Katz J, Tumpey T, Maines T. Comparison of the levels of infectious virus in respirable aerosols exhaled by ferrets infected with influenza viruses exhibiting diverse transmissibility phenotypes. J Virol. 2013;87:7864-73 pubmed publisher
    ..influenza viruses exhibiting diverse respiratory droplet transmission efficiencies, we are able to report that ferrets infected by highly transmissible influenza viruses exhale a greater number of aerosol particles and more ..
  52. Belser J, Katz J, Tumpey T. The ferret as a model organism to study influenza A virus infection. Dis Model Mech. 2011;4:575-9 pubmed publisher
    ..We highlight the recent and emerging uses of this species in influenza virus research that are advancing our understanding of virus-host interactions. ..
  53. Alves Pinto A, Sollini J, Sumner C. Signal detection in animal psychoacoustics: analysis and simulation of sensory and decision-related influences. Neuroscience. 2012;220:215-27 pubmed publisher
    ..Further analysis showed that ferrets were changing their decision criteria, almost optimally, to maximise the reward obtained in a session...
  54. Tretyakova I, Pearce M, Florese R, Tumpey T, Pushko P. Intranasal vaccination with H5, H7 and H9 hemagglutinins co-localized in a virus-like particle protects ferrets from multiple avian influenza viruses. Virology. 2013;442:67-73 pubmed publisher
    ..Intranasal vaccination of ferrets with the VLPs resulted in induction of serum antibody responses and efficient protection against experimental ..
  55. Guarnaccia T, Carolan L, Maurer Stroh S, Lee R, Job E, Reading P, et al. Antigenic drift of the pandemic 2009 A(H1N1) influenza virus in A ferret model. PLoS Pathog. 2013;9:e1003354 pubmed publisher
    ..passaging of A(H1N1)pdm09 virus by contact transmission through two independent series of suboptimally vaccinated ferrets resulted in selection of variant viruses with an amino acid substitution (N156K, H1 numbering without signal ..
  56. Kelava I, Reillo I, Murayama A, Kalinka A, Stenzel D, Tomancak P, et al. Abundant occurrence of basal radial glia in the subventricular zone of embryonic neocortex of a lissencephalic primate, the common marmoset Callithrix jacchus. Cereb Cortex. 2012;22:469-81 pubmed publisher
  57. Govorkova E, Marathe B, Prevost A, Rehg J, Webster R. Assessment of the efficacy of the neuraminidase inhibitor oseltamivir against 2009 pandemic H1N1 influenza virus in ferrets. Antiviral Res. 2011;91:81-8 pubmed publisher
    ..Oseltamivir (25 mg/kg/day twice daily for 5 days) was orally administered to groups of ferrets, starting either 2 or 24 h after inoculation with 10(6)PFU of A/California/04/2009 (H1N1) influenza virus...
  58. Yen H, Liang C, Wu C, Forrest H, Ferguson A, Choy K, et al. Hemagglutinin-neuraminidase balance confers respiratory-droplet transmissibility of the pandemic H1N1 influenza virus in ferrets. Proc Natl Acad Sci U S A. 2011;108:14264-9 pubmed publisher
    ..the pandemic H1N1 virus among humans, we evaluated the direct-contact and respiratory-droplet transmissibility in ferrets of representative swine influenza viruses of different lineages obtained through a 13-y surveillance program in ..
  59. Nam J, Kim E, Song D, Choi Y, Kim J, Poo H. Emergence of mammalian species-infectious and -pathogenic avian influenza H6N5 virus with no evidence of adaptation. J Virol. 2011;85:13271-7 pubmed publisher
    ..The isolate also productively infected ferrets, with direct evidence of contact transmission, but no disease or transmission was seen in pigs...
  60. Fang Y, Banner D, Kelvin A, Huang S, Paige C, Corfe S, et al. Seasonal H1N1 influenza virus infection induces cross-protective pandemic H1N1 virus immunity through a CD8-independent, B cell-dependent mechanism. J Virol. 2012;86:2229-38 pubmed publisher
    ..we have found that a first infection with the A/Brisbane/59/2007 virus strain confers heterologous protection in ferrets and mice against a subsequent pdmH1N1 (A/Mexico/4108/2009) virus infection through a cross-reactive but non-..
  61. Schrauwen E, Herfst S, Leijten L, van Run P, Bestebroer T, Linster M, et al. The multibasic cleavage site in H5N1 virus is critical for systemic spread along the olfactory and hematogenous routes in ferrets. J Virol. 2012;86:3975-84 pubmed publisher
    ..Here we determined the virus distribution of HPAI H5N1 virus in ferrets in time and space-including along the olfactory route-and the role of the MBCS in systemic replication...
  62. Jonsson C, Camp J, Wu A, Zheng H, Kraenzle J, Biller A, et al. Molecular imaging reveals a progressive pulmonary inflammation in lower airways in ferrets infected with 2009 H1N1 pandemic influenza virus. PLoS ONE. 2012;7:e40094 pubmed publisher
    ..coupled with CT (FDG-PET/CT) to gain insight into the spatiotemporal progression of the inflammatory response of ferrets infected with a clinical isolate of a pandemic influenza virus, H1N1 (H1N1pdm)...
  63. Verma S, Dimitrova M, Munjal A, Fontana J, Crevar C, Carter D, et al. Oligomeric recombinant H5 HA1 vaccine produced in bacteria protects ferrets from homologous and heterologous wild-type H5N1 influenza challenge and controls viral loads better than subunit H5N1 vaccine by eliciting high-affinity antibodies. J Virol. 2012;86:12283-93 pubmed publisher
    ..HA1 proteins from H5N1 (A/Vietnam/1203/04) with those of the egg-based licensed subunit H5N1 (SU-H5N1) vaccine in ferrets challenged with homologous or heterologous H5N1 highly pathogenic influenza strains...
  64. Liu G, Song L, Reiserova L, Trivedi U, Li H, Liu X, et al. Flagellin-HA vaccines protect ferrets and mice against H5N1 highly pathogenic avian influenza virus (HPAIV) infections. Vaccine. 2012;30:6833-8 pubmed publisher
    ..HA-specific IgG, reduced nasal virus shedding, and conferred full protection against a lethal A/VN infection in ferrets. Furthermore, we show that similar flagellin-HA vaccine candidates of two other H5N1 HPAIV are immunogenic and/or ..
  65. Di Girolamo N, Andreani V, Guandalini A, Selleri P. Evaluation of intraocular pressure in conscious ferrets (Mustela putorius furo) by means of rebound tonometry and comparison with applanation tonometry. Vet Rec. 2013;172:396 pubmed publisher
    To determine normal intraocular pressure (IOP) values by means of rebound tonometry in unanaesthetised ferrets, and to compare rebound and applanation tonometry, 55 clinically healthy ferrets were included in an observational, ..
  66. Marsh G, Virtue E, Smith I, Todd S, Arkinstall R, Frazer L, et al. Recombinant Hendra viruses expressing a reporter gene retain pathogenicity in ferrets. Virol J. 2013;10:95 pubmed publisher
    ..Hendra virus (HeV) is an Australian bat-borne zoonotic paramyxovirus that repeatedly spills-over to horses causing fatal disease. Human cases have all been associated with close contact with infected horses...
  67. Srinivasan K, Raman R, Jayaraman A, Viswanathan K, Sasisekharan R. Quantitative characterization of glycan-receptor binding of H9N2 influenza A virus hemagglutinin. PLoS ONE. 2013;8:e59550 pubmed publisher
    ..two amino acid changes in HA and a single amino acid change in NA that confer respiratory droplet transmission in ferrets. We previously demonstrated for human-adapted H1, H2 and H3 subtypes that quantitative binding affinity of their ..
  68. Jones J, Baranovich T, Marathe B, Danner A, Seiler J, Franks J, et al. Risk assessment of H2N2 influenza viruses from the avian reservoir. J Virol. 2014;88:1175-88 pubmed publisher
    ..Multiple isolates replicated in ferrets, and 3 viruses were transmitted to direct-contact cage mates...
  69. Bodewes R, Kreijtz J, van Amerongen G, Fouchier R, Osterhaus A, Rimmelzwaan G, et al. Pathogenesis of Influenza A/H5N1 virus infection in ferrets differs between intranasal and intratracheal routes of inoculation. Am J Pathol. 2011;179:30-6 pubmed publisher
    ..Intranasal inoculation of ferrets with influenza A/H5N1 virus causes lesions in both the respiratory tract and extrarespiratory organs (primarily ..
  70. Keiser N, Engelhardt J. New animal models of cystic fibrosis: what are they teaching us?. Curr Opin Pulm Med. 2011;17:478-83 pubmed publisher
    ..disease to benefit from the directed engineering of three different species of animal models (mice, pigs, and ferrets)...
  71. Ducatez M, Hause B, Stigger Rosser E, Darnell D, CORZO C, Juleen K, et al. Multiple reassortment between pandemic (H1N1) 2009 and endemic influenza viruses in pigs, United States. Emerg Infect Dis. 2011;17:1624-9 pubmed publisher
    ..viruses in vitro supported these observations; similarly, a representative reassortant virus replicated in ferrets to the same extent as did pandemic (H1N1) 2009 and endemic swine virus...
  72. Perrott M, Sigurdson C, Mason G, Hoover E. Evidence for distinct chronic wasting disease (CWD) strains in experimental CWD in ferrets. J Gen Virol. 2012;93:212-21 pubmed publisher
    ..Here, we report that infection of ferrets with either of two ferret CWD isolates by various routes of exposure has revealed biologically distinct strain-..
  73. van Doremalen N, Shelton H, Roberts K, Jones I, Pickles R, Thompson C, et al. A single amino acid in the HA of pH1N1 2009 influenza virus affects cell tropism in human airway epithelium, but not transmission in ferrets. PLoS ONE. 2011;6:e25755 pubmed publisher
    ..viral growth in human airway epithelium did not abrogate respiratory droplet transmission of pH1N1 2009 E227A in ferrets. Thus, acquisition of E at residue 227 was not solely responsible for the ability of pH1N1 2009 to transmit ..
  74. Chen Z, Kim L, Subbarao K, Jin H. The 2009 pandemic H1N1 virus induces anti-neuraminidase (NA) antibodies that cross-react with the NA of H5N1 viruses in ferrets. Vaccine. 2012;30:2516-22 pubmed publisher
    ..H6 reassortant viruses was performed to examine the neuraminidase (NA)-specific antibody response in ferrets immunized with live-attenuated influenza vaccine (LAIV) strains...
  75. Horn C, Meyers K, Pak D, Nagy A, Apfel C, Williams B. Post-anesthesia vomiting: impact of isoflurane and morphine on ferrets and musk shrews. Physiol Behav. 2012;106:562-8 pubmed publisher
    ..b>Ferrets (N=34) were initially used because they have served as a gold standard for emesis research...
  76. Pearce M, Belser J, Gustin K, Pappas C, Houser K, Sun X, et al. Seasonal trivalent inactivated influenza vaccine protects against 1918 Spanish influenza virus infection in ferrets. J Virol. 2012;86:7118-25 pubmed publisher
    ..seasonal TIV induces neutralizing antibodies that cross-react with the reconstructed 1918 pandemic virus in ferrets. TIV-immunized ferrets subsequently challenged with the 1918 virus displayed significant reductions in fever, ..
  77. Zhang Y, Zhang Q, Gao Y, He X, Kong H, Jiang Y, et al. Key molecular factors in hemagglutinin and PB2 contribute to efficient transmission of the 2009 H1N1 pandemic influenza virus. J Virol. 2012;86:9666-74 pubmed publisher
    ..of respiratory droplet transmission in guinea pigs and reduced the virus's ability to replicate in the lungs of ferrets. The change from alanine (A) to threonine (T) at position 271 of PB2 also abolished the virus's respiratory ..
  78. Nishiura H, Yen H, Cowling B. Sample size considerations for one-to-one animal transmission studies of the influenza A viruses. PLoS ONE. 2013;8:e55358 pubmed publisher
    ..The analyses are illustrated on transmission studies of influenza A viruses in the ferret model...
  79. Cheng X, Zengel J, Suguitan A, Xu Q, Wang W, Lin J, et al. Evaluation of the humoral and cellular immune responses elicited by the live attenuated and inactivated influenza vaccines and their roles in heterologous protection in ferrets. J Infect Dis. 2013;208:594-602 pubmed publisher
    ..to the antibody response but also to the cell-mediated and local mucosal immune responses, particularly in naive ferrets. These findings may explain why the LAIV is immunologically superior and offers immediate protection after a ..
  80. Kreijtz J, Kroeze E, Stittelaar K, de Waal L, van Amerongen G, van Trierum S, et al. Low pathogenic avian influenza A(H7N9) virus causes high mortality in ferrets upon intratracheal challenge: a model to study intervention strategies. Vaccine. 2013;31:4995-9 pubmed publisher
    ..this virus infection in humans is presented to evaluate the pathogenesis of the infection in a mammalian host, as ferrets have been shown to mimic the pathogenesis of human infection with influenza viruses most closely...
  81. Belser J, Gustin K, Pearce M, Maines T, Zeng H, Pappas C, et al. Pathogenesis and transmission of avian influenza A (H7N9) virus in ferrets and mice. Nature. 2013;501:556-9 pubmed publisher
    ..and A/Shanghai/1/2013 (H7N9) viruses, isolated from fatal human cases, to cause disease in mice and ferrets and to transmit to naive animals...
  82. Lakdawala S, Shih A, Jayaraman A, Lamirande E, Moore I, Paskel M, et al. Receptor specificity does not affect replication or virulence of the 2009 pandemic H1N1 influenza virus in mice and ferrets. Virology. 2013;446:349-56 pubmed publisher
    ..H1N1 (pH1N1) viruses with either predominant ?2,3 or ?2,6 SA binding and evaluated these viruses in mice and ferrets. The ?2,3 pH1N1 virus had similar virulence in mice and replicated to similar titers in the respiratory tract of ..
  83. Houser K, Pearce M, Katz J, Tumpey T. Impact of prior seasonal H3N2 influenza vaccination or infection on protection and transmission of emerging variants of influenza A(H3N2)v virus in ferrets. J Virol. 2013;87:13480-9 pubmed publisher
    ..It has been previously demonstrated in ferrets that A(H3N2)v viruses transmit as efficiently as seasonal influenza viruses, raising concern over the pandemic ..
  84. Fisher J, Zhang Y, Engelhardt J. Comparative biology of cystic fibrosis animal models. Methods Mol Biol. 2011;742:311-34 pubmed publisher
    ..lung cell biology and cystic fibrosis transmembrane conductance regulator (CFTR) biology among mice, pigs, and ferrets that has implications for CF disease modeling in these species...
  85. Paik S, Ringach D. Retinal origin of orientation maps in visual cortex. Nat Neurosci. 2011;14:919-25 pubmed publisher
    ..we show that such a pattern is observed in individuals of four different species: monkeys, cats, tree shrews and ferrets. The proposed mechanism explains how orientation maps can develop without requiring precise patterns of ..
  86. Kimble J, Sorrell E, Shao H, Martin P, Perez D. Compatibility of H9N2 avian influenza surface genes and 2009 pandemic H1N1 internal genes for transmission in the ferret model. Proc Natl Acad Sci U S A. 2011;108:12084-8 pubmed publisher
    ..genes in the context of the internal genes of a pH1N1 virus to efficiently transmit via respiratory droplets in ferrets. We generated reassorted viruses carrying the HA gene alone or in combination with the NA gene of a prototypical ..
  87. van den Brand J, Stittelaar K, Leijten L, van Amerongen G, Simon J, Osterhaus A, et al. Modification of the ferret model for pneumonia from seasonal human influenza A virus infection. Vet Pathol. 2012;49:562-8 pubmed publisher
    ..A conventional animal model--intranasal inoculation of ferrets with 10(6) median tissue culture infectious dose of virus--results in disease that is neither consistent nor ..
  88. Pearce M, Jayaraman A, Pappas C, Belser J, Zeng H, Gustin K, et al. Pathogenesis and transmission of swine origin A(H3N2)v influenza viruses in ferrets. Proc Natl Acad Sci U S A. 2012;109:3944-9 pubmed publisher
    ..High titers of infectious virus were detected in nasal turbinates and nasal wash samples of A(H3N2)v-inoculated ferrets. All four A(H3N2)v viruses possessed the capacity to spread efficiently between cohoused ferrets, and the 2010 ..
  89. Osterholm M, Kelley N. Mammalian-transmissible H5N1 influenza: facts and perspective. MBio. 2012;3:e00045-12 pubmed publisher
    ..in creating mutant isolates of H5N1 influenza A virus that can be transmitted via the respiratory route between ferrets; concern has been raised regarding human-to-human transmissibility of these or similar laboratory-generated ..
  90. Koster F, Gouveia K, Zhou Y, Lowery K, Russell R, Macinnes H, et al. Exhaled aerosol transmission of pandemic and seasonal H1N1 influenza viruses in the ferret. PLoS ONE. 2012;7:e33118 pubmed publisher
    ..experimental method to detect exhaled viral aerosol transmission between unanesthetized infected and susceptible ferrets, measured aerosol particle size and number, and quantified the viral genomic RNA in the exhaled aerosol...
  91. Driskell E, Pickens J, Humberd Smith J, Gordy J, Bradley K, Steinhauer D, et al. Low pathogenic avian influenza isolates from wild birds replicate and transmit via contact in ferrets without prior adaptation. PLoS ONE. 2012;7:e38067 pubmed publisher
    ..lack of ?2,6 linked SA binding, these AIVs productively infected both the upper and lower respiratory tract of ferrets, resulting in nasal viral shedding and pulmonary lesions with minimal morbidity...
  92. Rabinowitz N, Willmore B, Schnupp J, King A. Spectrotemporal contrast kernels for neurons in primary auditory cortex. J Neurosci. 2012;32:11271-84 pubmed publisher
    ..Adding contrast kernels to STRF models also yields considerable improvements in the ability to capture and predict how auditory cortical neurons respond to statistically complex sounds...