miniature swine


Summary: Genetically developed small pigs for use in biomedical research. There are several strains - Yucatan miniature, Sinclair miniature, and Minnesota miniature.

Top Publications

  1. Edwards J, Alloosh M, Long X, Dick G, Lloyd P, Mokelke E, et al. Adenosine A1 receptors in neointimal hyperplasia and in-stent stenosis in Ossabaw miniature swine. Coron Artery Dis. 2008;19:27-31 pubmed publisher
    ..In this study we tested the hypothesis that adenosine A1 receptor upregulation is associated with neointimal hyperplasia within coronary artery stents...
  2. Diswall M, Angstrom J, Schuurman H, Dor F, Rydberg L, Breimer M. Glycolipid studies in small intestine and pancreas of alpha1,3-galactosyltransferase knockout miniature swine: alpha1,3GALT-KO animals lack alphaGAL antigens and contain novel blood group H compounds. Transplant Proc. 2008;40:543-6 pubmed publisher
    ..However, Galalpha1,3Gal (Gal) determinant elimination may expose cryptic carbohydrate antigens and/or generate new antigens that might interfere with the human immune response...
  3. Lloyd P, Sheehy A, Edwards J, Mokelke E, Sturek M. Leukemia inhibitory factor is upregulated in coronary arteries of Ossabaw miniature swine after stent placement. Coron Artery Dis. 2008;19:217-26 pubmed publisher
    ..Thus, we hypothesized that LIF expression might be altered during in-stent neointimal hyperplasia. Ossabaw miniature swine, a unique large-animal model of metabolic syndrome and cardiovascular disease, were used for these studies...
  4. Takai H, Miyoshi A, Yamazaki M, Adachi K, Katagiri K, Arakawa H, et al. Granulocyte colony-stimulating factor has no adverse effects on atherosclerotic lesions in high cholesterol-fed miniature Swine. J Vet Med Sci. 2008;70:943-50 pubmed
    ..The animal model for atherosclerosis was produced by feeding miniature swine a high-cholesterol diet for 3 months...
  5. Satoda N, Shoji T, Wu Y, Fujinaga T, Chen F, Aoyama A, et al. Value of FOXP3 expression in peripheral blood as rejection marker after miniature swine lung transplantation. J Heart Lung Transplant. 2008;27:1293-301 pubmed publisher
    ..There is emerging clinical evidence that, paradoxically, expression of forkhead box P3 (FOXP3, a specific marker for the regulatory T cells) is upregulated within rejecting grafts...
  6. Jensen S, Bornstein M, Dard M, Bosshardt D, Buser D. Comparative study of biphasic calcium phosphates with different HA/TCP ratios in mandibular bone defects. A long-term histomorphometric study in minipigs. J Biomed Mater Res B Appl Biomater. 2009;90:171-81 pubmed publisher
    ..TRAP-positive multinucleated cells were identified on BCP and DBBM surfaces without showing typical signs of resorption lacunae...
  7. Lee L, Alloosh M, Saxena R, Van Alstine W, Watkins B, Klaunig J, et al. Nutritional model of steatohepatitis and metabolic syndrome in the Ossabaw miniature swine. Hepatology. 2009;50:56-67 pubmed publisher
    ..Compared with controls, the M-Ath diet group had significantly lower serum adiponectin but higher serum leptin and tumor necrosis factor (TNF) levels and higher hepatic triglyceride and malondialdehyde levels...
  8. Itoh Y, Shinya K, Kiso M, Watanabe T, Sakoda Y, Hatta M, et al. In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses. Nature. 2009;460:1021-5 pubmed publisher
    ..Finally, we show that CA04 is sensitive to approved and experimental antiviral drugs, suggesting that these compounds could function as a first line of defence against the recently declared S-OIV pandemic...
  9. Sahara H, Shimizu A, Setoyama K, Okumi M, Oku M, Samelson Jones E, et al. Carbon monoxide reduces pulmonary ischemia-reperfusion injury in miniature swine. J Thorac Cardiovasc Surg. 2010;139:1594-601 pubmed publisher
    ..The aims of this translational research were to establish an in situ porcine lung model of warm ischemia-reperfusion injury and to evaluate the cytoprotective effects of low-dose inhaled carbon monoxide in this model...

More Information

Publications146 found, 100 shown here

  1. Duran Struuck R, Cho P, Teague A, Fishman B, Fishman A, Hanekamp J, et al. Myelogenous leukemia in adult inbred MHC-defined miniature swine: a model for human myeloid leukemias. Vet Immunol Immunopathol. 2010;135:243-56 pubmed publisher
    ..occurring within highly inbred, histocompatible sublines of Massachusetts General Hospital (MGH) MHC-defined miniature swine. In cases where a neoplasm was suspected based on clinical observations, samples were obtained for complete ..
  2. Bell L, Lee L, Saxena R, Bemis K, Wang M, Theodorakis J, et al. Serum proteomic analysis of diet-induced steatohepatitis and metabolic syndrome in the Ossabaw miniature swine. Am J Physiol Gastrointest Liver Physiol. 2010;298:G746-54 pubmed publisher
    ..This serum proteomic analysis provides additional information about the pathogenesis of NASH and further characterizes our large animal model of diet-induced steatohepatitis and metabolic syndrome in Ossabaw pigs...
  3. Emter C, Baines C. Low-intensity aerobic interval training attenuates pathological left ventricular remodeling and mitochondrial dysfunction in aortic-banded miniature swine. Am J Physiol Heart Circ Physiol. 2010;299:H1348-56 pubmed publisher
    ..AB) sedentary (HFSED; n = 6), AB exercise-trained (HFTR, n = 5), and control sedentary (n = 5) male Yucatan miniature swine. LV hypertrophy was present in both AB groups before the start of training, as indicated by increases in LV ..
  4. Svendsen O. The minipig in toxicology. Exp Toxicol Pathol. 2006;57:335-9 pubmed
    ..The principal disadvantage is that toxicity testing in minipigs may require more test compound than the traditional species...
  5. Du Z, Vincent Naulleau S, Gilbert H, Vignoles F, Créchet F, Shimogiri T, et al. Detection of novel quantitative trait loci for cutaneous melanoma by genome-wide scan in the MeLiM swine model. Int J Cancer. 2007;120:303-20 pubmed
    ..05). Taken together, these results indicate that MeLiM swine is a model for human multigenic diseases. Comparative mapping revealed human regions of interest to search for new melanoma susceptibility candidates...
  6. Martin S, Wilkinson R, Fishman J. Genomic presence of recombinant porcine endogenous retrovirus in transmitting miniature swine. Virol J. 2006;3:91 pubmed
    ..We describe two different recombinant PERV-AC sequences in the cellular DNA of some transmitting miniature swine. This is the first evidence of PERV-AC recombinant virus in porcine genomic DNA that may have resulted from ..
  7. Hector R, Meikle S, Grant L, Wilkinson R, Fishman J, Scobie L. Pre-screening of miniature swine may reduce the risk of transmitting human tropic recombinant porcine endogenous retroviruses. Xenotransplantation. 2007;14:222-6 pubmed
    It has been reported that peripheral blood mononuclear cells from miniature swine are capable of transmitting human tropic porcine endogenous retrovirus (PERV) recombinants to both human and pig cells...
  8. Ibi M, Ishisaki A, Yamamoto M, Wada S, Kozakai T, Nakashima A, et al. Establishment of cell lines that exhibit pluripotency from miniature swine periodontal ligaments. Arch Oral Biol. 2007;52:1002-8 pubmed
    ..It is not clear whether cells within the PDL fibroblast population retain the potency to differentiate into other cell types...
  9. Bourges D, Chevaleyre C, Wang C, Berri M, Zhang X, Nicaise L, et al. Differential expression of adhesion molecules and chemokines between nasal and small intestinal mucosae: implications for T- and sIgA+ B-lymphocyte recruitment. Immunology. 2007;122:551-61 pubmed
  10. Liu Y, Zheng Y, Ding G, Fang D, Zhang C, Bartold P, et al. Periodontal ligament stem cell-mediated treatment for periodontitis in miniature swine. Stem Cells. 2008;26:1065-73 pubmed publisher
    ..This study demonstrates the feasibility of using stem cell-mediated tissue engineering to treat periodontal diseases...
  11. Hoerbelt R, Johnston D, Shoji T, Houser S, Hasse R, Ledgerwood L, et al. Combination treatment with donor-specific transfusions and cyclosporine a induces long-term survival of cardiac allografts in miniature Swine. Transplantation. 2005;80:1275-82 pubmed
    To evaluate whether pretransplant donor-specific transfusions (DST) can induce tolerance to cardiac allografts in large animals, heterotopic cardiac transplants were performed across a class I MHC barrier in inbred miniature swine.
  12. Fujisawa K, Shimizu K, Uga S, Suzuki M, Nagano K, Murakami Y, et al. Changes in the crystalline lens resulting from insertion of a phakic IOL (ICL) into the porcine eye. Graefes Arch Clin Exp Ophthalmol. 2007;245:114-22 pubmed
    ..However, the cause of secondary cataracts has never been clarified or discussed to date...
  13. Wong B, Yamada K, Okumi M, Weiner J, O Malley P, Tseng Y, et al. Allosensitization does not increase the risk of xenoreactivity to alpha1,3-galactosyltransferase gene-knockout miniature swine in patients on transplantation waiting lists. Transplantation. 2006;82:314-9 pubmed
    The recent availability of alpha1,3-galactosyltransferase knockout (GalT-KO) miniature swine has eliminated anti-Gal antibodies as the major barrier to xenotransplantation, potentially bringing this modality closer to clinical ..
  14. Gerner W, Denyer M, Takamatsu H, Wileman T, Wiesmüller K, Pfaff E, et al. Identification of novel foot-and-mouth disease virus specific T-cell epitopes in c/c and d/d haplotype miniature swine. Virus Res. 2006;121:223-8 pubmed
    ..This is the first report on FMDV specific T-cell epitopes recognized by swine leukocyte antigen (SLA) inbred swine and provides information useful for the design of novel vaccines against FMDV...
  15. Lee M, Lee S, Lee S, Park S, Lee C, Kim K, et al. Comparative analysis of heart functions in micropigs and conventional pigs using echocardiography and radiography. J Vet Sci. 2007;8:7-14 pubmed
    ..Overall, it is expected that the values measured in this study will contribute to understanding of the physiological characteristics of micropigs...
  16. Dieckhoff B, Puhlmann J, Büscher K, Hafner Marx A, Herbach N, Bannert N, et al. Expression of porcine endogenous retroviruses (PERVs) in melanomas of Munich miniature swine (MMS) Troll. Vet Microbiol. 2007;123:53-68 pubmed
    ..HERV-K, in human melanomas, we studied the expression of PERVs in melanomas of selectively bred Munich miniature swine (MMS) Troll...
  17. Berri M, Meurens F, Lefèvre F, Chevaleyre C, Zanello G, Gerdts V, et al. Molecular cloning and functional characterization of porcine CCL28: possible involvement in homing of IgA antibody secreting cells into the mammary gland. Mol Immunol. 2008;45:271-7 pubmed
    ..CCL28 protein was excreted in sow's milk sustaining that this chemokine plays a key role of IgA-ASCs accumulation in this tissue and thus controls the passive transfer level of IgA antibodies from mother to infant...
  18. Gahlert M, Gudehus T, Eichhorn S, Steinhauser E, Kniha H, Erhardt W. Biomechanical and histomorphometric comparison between zirconia implants with varying surface textures and a titanium implant in the maxilla of miniature pigs. Clin Oral Implants Res. 2007;18:662-8 pubmed
    ..The influence of surface modification on the osseointegration of this material has not been extensively investigated...
  19. Cho P, Lo D, Wikiel K, Rowland H, Coburn R, McMorrow I, et al. Establishment of transplantable porcine tumor cell lines derived from MHC-inbred miniature swine. Blood. 2007;110:3996-4004 pubmed
    ..and highly inbred sublines of Massachusetts General Hospital major histocompatibility complex (MHC)-inbred miniature swine. Autopsies were performed routinely on swine that died unexpectedly or had suspicion of malignancy based on ..
  20. Diswall M, Angstrom J, Schuurman H, Dor F, Rydberg L, Breimer M. Studies on glycolipid antigens in small intestine and pancreas from alpha1,3-galactosyltransferase knockout miniature swine. Transplantation. 2007;84:1348-56 pubmed
    ..Galalpha1,3Gal determinant elimination may expose cryptic carbohydrate antigens and/or generate new antigens. This is the first biochemical study of carbohydrate antigens in GalT-KO pig organs...
  21. Jung M, Breusch S, Daecke W, Gotterbarm T. The effect of defect localization on spontaneous repair of osteochondral defects in a Gottingen minipig model: a retrospective analysis of the medial patellar groove versus the medial femoral condyle. Lab Anim. 2009;43:191-7 pubmed publisher
    ..Since regenerating with less hyaline-like repair tissue and less subchondral cyst formation, TG is more favourable for experimental osteochondral defect healing in this model. ..
  22. Rosendal F, Chakravarty M, Sunde N, Rodell A, Jonsdottir K, Pedersen M, et al. Defining the intercommissural plane and stereotactic coordinates for the Basal Ganglia in the Göttingen minipig brain. Stereotact Funct Neurosurg. 2010;88:138-46 pubmed publisher
    ..We found the variability of the intercommissural line to be small in the Göttingen minipig and the variability of the basal ganglia structures to the mid-commissural point to be minor. ..
  23. Lu D, Fan H, Wang H, Hu K, Zhang J, Yu S. Effect of the addition of tramadol to a combination of tiletamine-zolazepam and xylazine for anaesthesia of miniature pigs. Vet Rec. 2010;167:489-92 pubmed publisher
    ..The animals were much calmer during recovery after TZXT immobilisation. ..
  24. Duran Struuck R, Matar A, Crepeau R, Teague A, Horner B, Pathiraja V, et al. Donor Lymphocyte Infusion-Mediated Graft-versus-Host Responses in a Preclinical Swine Model of Haploidentical Hematopoietic Cell Transplantation. Biol Blood Marrow Transplant. 2016;22:1953-1960 pubmed publisher
    We previously described successful hematopoietic stem cell engraftment across MHC barriers in miniature swine without graft-versus-host disease (GVHD) using novel reduced-intensity conditioning regimens consisting of partial transient ..
  25. Gruber R, Ludwig A, Merten H, Pippig S, Kramer F, Schliephake H. Sinus floor augmentation with recombinant human growth and differentiation factor-5 (rhGDF-5): a pilot study in the Goettingen miniature pig comparing autogenous bone and rhGDF-5. Clin Oral Implants Res. 2009;20:175-82 pubmed publisher
    ..8%, 40.8%) (P=.027, P=.045). rhGDF-5 delivered on beta-TCP significantly enhanced bone formation compared with beta-TCP combined with autogenous bone in sinus lift procedures in miniature pigs. ..
  26. Planka L, Necas A, Srnec R, Rauser P, Stary D, Jancar J, et al. Use of allogenic stem cells for the prevention of bone bridge formation in miniature pigs. Physiol Res. 2009;58:885-93 pubmed
    ..This part of our experiment is significant in the effort to advance MSCs application in human medicine by using pig as a model, which is the next step after experimenting on rabbits. ..
  27. Chang H, George R, Schuleri K, Evers K, Kitagawa K, Lima J, et al. Prospective electrocardiogram-gated delayed enhanced multidetector computed tomography accurately quantifies infarct size and reduces radiation exposure. JACC Cardiovasc Imaging. 2009;2:412-20 pubmed publisher
    ..Although infarct SNR and CNR were significantly higher for the retrospective gated protocol, prospective ECG-gated DCE-MDCT provides high-resolution imaging of MI, while substantially lowering the radiation dose. ..
  28. Helke K, Nelson K, Sargeant A, Jacob B, McKeag S, Haruna J, et al. Background Pathological Changes in Minipigs: A Comparison of the Incidence and Nature among Different Breeds and Populations of Minipigs. Toxicol Pathol. 2016;44:325-37 pubmed publisher
    Swine, especially the miniature swine or minipigs, are increasingly being used in preclinical safety assessment of small molecules, biopharmaceutical agents, and medical devices as an alternate nonrodent species...
  29. Funk J, Krummrey G, Perka C, Raschke M, Bail H. Distraction osteogenesis enhances remodeling of remote bones of the skeleton: a pilot study. Clin Orthop Relat Res. 2009;467:3199-205 pubmed publisher
    ..25 microm(2)/day (330.84-467.71 microm(2)/day) during consolidation. Thus, a short period of distraction osteogenesis appears to have an anabolic effect on the mineral apposition rate of remote cortical bone. ..
  30. Lawler M, Tayebaty F, Williams W, Troulis M, Kaban L. Histomorphometric analysis of the porcine mandibular distraction wound. J Oral Maxillofac Surg. 2010;68:1543-54 pubmed publisher
    ..Bone formation occurred earlier in the superior/middle portions of the wound, possibly owing to osteoinductive properties of developing tooth buds and the inferior alveolar nerve, respectively. ..
  31. Johnson L, Parker J, Laughlin M. Chronic exercise training improves ACh-induced vasorelaxation in pulmonary arteries of pigs. J Appl Physiol (1985). 2000;88:443-51 pubmed
    ..Pulmonary artery rings (2- to 3-mm OD) were obtained from female Yucatan miniature swine with surgically induced coronary artery occlusion (ameroid occluder)...
  32. Mendrinos E, Petropoulos I, Mangioris G, Papadopoulou D, Stangos A, Pournaras C. Lactate-induced retinal arteriolar vasodilation implicates neuronal nitric oxide synthesis in minipigs. Invest Ophthalmol Vis Sci. 2008;49:5060-6 pubmed publisher
    ..Moreover, juxta-arteriolar L-NAME microinjection significantly suppressed the vasodilatory effect of L-lactate. These data suggest that neuronal-derived NO is an important mediator of lactate-induced vasodilation in minipigs. ..
  33. Melvin A, Litsky A, Juncosa Melvin N. FiberSecure suture compared to braided polyester suture. J Biomed Mater Res B Appl Biomater. 2017;105:1126-1130 pubmed publisher
    ..commercially available braided polyester suture (Mersilene) in the closure of abdominal muscle incisions in miniature swine at approximately 3 months postsurgery...
  34. Liu Z, Shcherbatyy V, Perkins J. Functional loads of the tongue and consequences of volume reduction. J Oral Maxillofac Surg. 2008;66:1351-61 pubmed publisher
  35. Torikai K, Ichikawa H, Hirakawa K, Matsumiya G, Kuratani T, Iwai S, et al. A self-renewing, tissue-engineered vascular graft for arterial reconstruction. J Thorac Cardiovasc Surg. 2008;136:37-45, 45.e1 pubmed publisher
    ..These results suggest that our tissue-engineered vascular graft shows promise as an arterial conduit prosthesis. ..
  36. Ma J, Pan J, Tan B, Cui F. Determination of critical size defect of minipig mandible. J Tissue Eng Regen Med. 2009;3:615-22 pubmed publisher
    ..For defects retained by two reconstructive plates, the CSDs in the minipig mandible models with and without periosteum were determined as 6 and 2 cm, respectively. ..
  37. Balcells M, Martorell J, Olivé C, Santacana M, Chitalia V, Cardoso A, et al. Smooth muscle cells orchestrate the endothelial cell response to flow and injury. Circulation. 2010;121:2192-9 pubmed publisher
    ..These interactions may explain the impact of local antiproliferative delivery that targets SMC proliferation and suggest that future stents integrate design influences on flow and drug effects on their molecular targets. ..
  38. Balakrishnan B, Dooley J, Kopia G, Edelman E. Thrombus causes fluctuations in arterial drug delivery from intravascular stents. J Control Release. 2008;131:173-80 pubmed publisher
    ..The mural thrombus effects on arterial drug deposition may be circumvented by forcing slow, rate limiting arterial transport that cannot be further hindered by mural thrombus. ..
  39. Broscheit J, Weidemann F, Strotmann J, Steendijk P, Eberbach N, Karle H, et al. The relationship between carotid blood-flow velocity and the left ventricular area during acute regional ischemia. J Cardiothorac Vasc Anesth. 2008;22:823-31 pubmed publisher
    ..The ability of E'(es) to indicate contractility during acute reduced coronary blood flow is limited. ..
  40. Xu Y, Liu Y, Lv X, Yu C, Li X. A novel hybrid method for creating a porcine model of cyanotic congenital heart defect with decreased pulmonary blood flow. J Surg Res. 2009;154:262-6 pubmed publisher
    ..Application of this experimental design may enhance our understanding and possibly influence the treatment of patients who have cyanotic heart disease with decreased pulmonary blood flow. ..
  41. De Keyzer D, Karabina S, Wei W, Geeraert B, Stengel D, Marsillach J, et al. Increased PAFAH and oxidized lipids are associated with inflammation and atherosclerosis in hypercholesterolemic pigs. Arterioscler Thromb Vasc Biol. 2009;29:2041-6 pubmed publisher
    ..Our cell experiments suggest that oxidized LDL can induce PAFAH, resulting in accumulation of lysophosphatidylcholine that increases the inflammatory action of oxidized LDL. ..
  42. Ge L, Zheng S, Wei H. Comparison of histological structure and biocompatibility between human acellular dermal matrix (ADM) and porcine ADM. Burns. 2009;35:46-50 pubmed publisher
    ..05) between the biocompatibility of the two ADMs. Based on these results, we conclude that porcine ADM bears a strong similarity to human ADM, and might be a substitute for human ADM in the future. ..
  43. Mai R, Lux R, Proff P, Lauer G, Pradel W, Leonhardt H, et al. O-phospho-L-serine: a modulator of bone healing in calcium-phosphate cements. Biomed Tech (Berl). 2008;53:229-33 pubmed publisher
    ..The addition of phosphoserine is very promising in terms of influencing resorption features and bone regeneration. ..
  44. Stampfl U, Radeleff B, Sommer C, Stampfl S, Lopez Benitez R, Thierjung H, et al. Paclitaxel-induced arterial wall toxicity and inflammation: part 2--long-term tissue response in a minipig model. J Vasc Interv Radiol. 2009;20:1608-16 pubmed publisher
  45. Koo O, Park H, Kwon D, Kang J, Jang G, Lee B. Effect of recipient breed on delivery rate of cloned miniature pig. Zygote. 2009;17:203-7 pubmed publisher
    ..Our results indicate that the miniature pig is the preferred embryo recipient breed than domestic pig for producing cloned miniature piglets. ..
  46. Assenza B, Scarano A, Perrotti V, Vozza I, Quaranta A, Quaranta M, et al. Peri-implant bone reactions around immediately loaded conical implants with different prosthetic suprastructures: histological and histomorphometrical study on minipigs. Clin Oral Investig. 2010;14:285-90 pubmed publisher
    ..A high quantity of mineralized bone was present around immediately loaded conical, root form implants. No differences in the peri-implant bone response were found in the groups with different prosthetic reconstructions...
  47. Kim S, Kim J, Lee E, Jeong Y, Hossein M, Park S, et al. Establishment and characterization of embryonic stem-like cells from porcine somatic cell nuclear transfer blastocysts. Zygote. 2010;18:93-101 pubmed publisher
    ..Microsatellite analysis confirmed that they were genetically identical to its donor cells. Combined with gene targeting, our results may contribute to developing an efficient method for producing transgenic pigs for various purposes. ..
  48. Miyoshi K, Mori H, Mizobe Y, Akasaka E, Ozawa A, Yoshida M, et al. Development of a noninvasive monitoring system for evaluation of Oct-3/4 promoter status in miniature pig somatic cell nuclear transfer embryos. J Reprod Dev. 2009;55:661-9 pubmed
  49. Elgeti T, Laule M, Kaufels N, Schnorr J, Hamm B, Samani A, et al. Cardiac MR elastography: comparison with left ventricular pressure measurement. J Cardiovasc Magn Reson. 2009;11:44 pubmed publisher
  50. Jones A, Rubin L, Magliola L. Endothelin-1 sensitivity of porcine coronary arteries is reduced by exercise training and is gender dependent. J Appl Physiol (1985). 1999;87:1172-7 pubmed
    ..of coronary smooth muscle to endothelin-1 (ET-1), with the adaptation being greater in male than in female miniature swine. The efficacy of training was similar in males and females...
  51. Henry M, Ulrichs K, Moskalenko V, Bonneau M, Kang C, Belcourt A, et al. Surface analysis of an encapsulation membrane after its implantation in mini-pigs. Biomed Mater. 2007;2:S78-89 pubmed publisher
    ..In conclusion, biological molecules adhered to the encapsulation membrane surface after implantation but the surface treatments remained unaltered. ..
  52. Guttman M, Raval A, Lederman R, McVeigh E. Real-time catheter-directed MRA with effective background suppression and persistent rendering. J Magn Reson Imaging. 2008;28:538-42 pubmed publisher
    ..Although designed for rapid deployment during rtMRI-guided interventional procedures, the technique may also be useful to supplement the study of vessel anatomy, flow, or perfusion. ..
  53. Leroy J, Cahill R, Perretta S, Forgione A, Dallemagne B, Marescaux J. Natural orifice translumenal endoscopic surgery (NOTES) applied totally to sigmoidectomy: an original technique with survival in a porcine model. Surg Endosc. 2009;23:24-30 pubmed publisher
    ..There was no evidence of luminal stricturing, peritonitis, or intraabdominal sepsis in any animal. Using this experimental model, colonic resection and reanastomosis can be performed safely within the NOTES format. ..
  54. Byers C, McGuire J, Hulet S, Burnett D, Gaviola B, Jakubowski E, et al. Gas chromatography-tandem mass spectrometry analysis of red blood cells from Göttingen minipig following whole-body vapor exposure to VX. J Anal Toxicol. 2008;32:57-62 pubmed
    ..GC-MS-MS analyses of RBC samples following VX exposure demonstrate this technique has both adequate sensitivity and specificity to indicate the severity of exposure. ..
  55. Thim T, Hagensen M, Wallace Bradley D, Granada J, Kaluza G, Drouet L, et al. Unreliable assessment of necrotic core by virtual histology intravascular ultrasound in porcine coronary artery disease. Circ Cardiovasc Imaging. 2010;3:384-91 pubmed publisher
    ..We found no correlation between necrotic core size determined by VH IVUS and real histology, questioning the ability of VH IVUS to detect rupture-prone plaques, so-called thin-cap fibroatheromas. ..
  56. Mizobe Y, Kurino S, Sata Y, Mori H, Yoshida M, Miyoshi K. Stage-specific effects of osmolarity of a culture medium on development of pig oocytes and miniature pig somatic cell nuclear transfer embryos activated by ultrasound treatment. Anim Sci J. 2010;81:453-60 pubmed publisher
    ..These results showed that the high osmolarity of a culture medium induced by increasing NaCl concentration during the first 2 days improves the development of pig oocytes and miniature pig SCNT embryos activated by ultrasound. ..
  57. Wang Z, Navarro Alvarez N, Shah J, Zhang H, Huang Q, Zheng Q, et al. Porcine Treg depletion with a novel diphtheria toxin-based anti-human CCR4 immunotoxin. Vet Immunol Immunopathol. 2016;182:150-158 pubmed publisher
    ..the lymph nodes following the anti-human CCR4 immunotoxin treatment in Massachusetts General Hospital (MGH) miniature swine. The depletion lasted for about one week with no significant reduction observed within CCR4- cell ..
  58. Wilms C, Mueller L, Lenk C, Wittkugel O, Helmke K, Krupski Berdien G, et al. Comparative study of portal vein embolization versus portal vein ligation for induction of hypertrophy of the future liver remnant using a mini-pig model. Ann Surg. 2008;247:825-34 pubmed publisher
    ..This is due to a more effective, durable occlusion of the portal branches. Formation of collaterals between occluded and nonoccluded liver parts seems to be the cause of inferior regeneration in the ligation group. ..
  59. Blum K, Hadamitzky C, Gratz K, Pabst R. Effects of autotransplanted lymph node fragments on the lymphatic system in the pig model. Breast Cancer Res Treat. 2010;120:59-66 pubmed publisher
    ..All lymph node fragments showed an organized structure histologically. Autologous lymph node transplantation has positive effects on the regeneration of lymph vessels and restoration of lymph flow after lymphadenectomy...
  60. Chen H, Liu Y, Li C, Guo X, Huang L. The susceptibility of three strains of Chinese minipigs to diet-induced type 2 diabetes mellitus. Lab Anim (NY). 2009;38:355-63 pubmed publisher
    ..These results provide a foundation for diabetes-related genetic analyses in minipigs with high and low susceptibility to diet-induced type 2 diabetes. ..
  61. Robich M, Chu L, Feng J, Burgess T, Laham R, Bianchi C, et al. Effects of selective cyclooxygenase-2 and nonselective cyclooxygenase inhibition on ischemic myocardium. J Thorac Cardiovasc Surg. 2010;140:1143-52 pubmed publisher
    ..Selective and nonselective cyclooxygenase inhibition are more complex in effect than previously published, but they did not decrease collateral-dependent blood flow to the myocardium in our model of chronic myocardial ischemia. ..
  62. Kragh P, Nielsen A, Li J, Du Y, Lin L, Schmidt M, et al. Hemizygous minipigs produced by random gene insertion and handmade cloning express the Alzheimer's disease-causing dominant mutation APPsw. Transgenic Res. 2009;18:545-58 pubmed publisher
    ..A rough estimate predicts that accumulation of the A beta peptide in the brain may develop at the age of 1-2 years. ..
  63. Kruse B, Thissen S, Warnecke G, Avsar M, Gottlieb J, Hohlfeld J, et al. Correlation of donor leukocyte chimerism with pulmonary allograft survival after immunosuppressive drug withdrawal in a porcine model. Transplantation. 2009;87:1468-77 pubmed publisher
    ..This study demonstrates a clear correlation of donor leukocyte chimerism with long-term allograft survival in a porcine allogeneic lung transplantation model. ..
  64. Ahn Y, Ryu J, Jeong H, Kim Y, Jeong M, Lee M, et al. Comparison of cardiac function and coronary angiography between conventional pigs and micropigs as measured by multidetector row computed tomography. J Vet Sci. 2008;9:121-6 pubmed
    ..It is expected that the results of this study will help improve understanding of cardiac function in micropigs. The data presented in this study suggest that MDCT is a feasible method for evaluating cardiac function in micropigs. ..
  65. Tanaka H, Igarashi T, Lefor A, Kobayashi E. The effects of fasting and general anesthesia on serum chemistries in KCG miniature pigs. J Am Assoc Lab Anim Sci. 2009;48:33-8 pubmed
    ..Investigators must be aware of the effects of anesthetic agents on experimental animals to provide optimal care and for interpretation of experimental data. ..
  66. Li X, Liu Y, Wang Q, Zhu Y, Lv X, Liu J. A novel and stable "two-hit" acute lung injury model induced by oleic acid in piglets. Acta Vet Scand. 2009;51:17 pubmed publisher
    ..The two-hit ALI animal model can be used to study the basic mechanism and the therapeutic strategies for pediatric ALI. ..
  67. Busenlechner D, Huber C, Vasak C, Dobsak A, Gruber R, Watzek G. Sinus augmentation analysis revised: the gradient of graft consolidation. Clin Oral Implants Res. 2009;20:1078-83 pubmed publisher
    ..32) after 12 weeks]. Based on the graft consolidation gradient, the impact of bone substitutes to modulate the process of bone formation and the kinetic of degradation within a distinct region of the augmented sinus can be investigated. ..
  68. Yamanaka K, Sugimura S, Wakai T, Kawahara M, Sato E. Acetylation level of histone H3 in early embryonic stages affects subsequent development of miniature pig somatic cell nuclear transfer embryos. J Reprod Dev. 2009;55:638-44 pubmed
  69. Sekijima M, Sahara H, Miki K, Villani V, Ariyoshi Y, Iwanaga T, et al. Hydrogen sulfide prevents renal ischemia-reperfusion injury in CLAWN miniature swine. J Surg Res. 2017;219:165-172 pubmed publisher
    ..In this study, we examined whether the administration of H2S offers cytoprotective effects on renal ischemia-reperfusion injury (IRI) in a preclinical miniature swine model.
  70. Murayama N, Kaneko N, Horiuchi K, Ohyama K, Shimizu M, Ito K, et al. Cytochrome P450-dependent drug oxidation activity of liver microsomes from Microminipigs, a possible new animal model for humans in non-clinical studies. Drug Metab Pharmacokinet. 2009;24:404-8 pubmed
    ..These findings should provide important information for greater understanding of drug metabolism in Microminipigs, as an experimental animal model for non-clinical use...
  71. Lionetti V, Aquaro G, Simioniuc A, Di Cristofano C, Forini F, Cecchetti F, et al. Severe mechanical dyssynchrony causes regional hibernation-like changes in pigs with nonischemic heart failure. J Card Fail. 2009;15:920-8 pubmed publisher
    ..05), whereas that of hexokinase type II was globally reduced by 83%. The combination of high heart rate and sustained dyssynchronous LV contraction causes asymmetrical myocardial hibernation, in absence of coronary artery stenosis. ..
  72. Phogat J, Parvizi N. Involvement of opioids and catecholamines in stress modulation of LH secretion in the male pig. Anim Reprod Sci. 2010;121:152-8 pubmed publisher
    ..In conclusion, although, the transient painful stress of NS does not affect the LH values, it alters the opioidergic and catecholaminergic-modulation of LH secretion. The interference with opioid system is possibly mediated by ACTH. ..
  73. Huang Z, Ge J, Sun A, Wang Y, Zhang S, Cui J, et al. Ligating LAD with its whole length rather than diagonal branches as coordinates is more advisable in establishing stable myocardial infarction model of swine. Exp Anim. 2010;59:431-9 pubmed
  74. Laughlin M, Schrage W, McAllister R, Garverick H, Jones A. Interaction of gender and exercise training: vasomotor reactivity of porcine skeletal muscle arteries. J Appl Physiol (1985). 2001;90:216-27 pubmed
    ..Male and female Yucatan miniature swine were exercise trained on a motor-driven treadmill or cage confined for 16-20 wk...
  75. Tahara Y, Honda S, Kamiya N, Piao H, Hirata A, Hayakawa E, et al. A solid-in-oil nanodispersion for transcutaneous protein delivery. J Control Release. 2008;131:14-8 pubmed publisher
    ..The results indicated the potential utility of the S/O nanodispersion as a novel vehicle for transcutaneous protein delivery. ..
  76. Omlor G, Bertram H, Kleinschmidt K, Fischer J, Brohm K, Guehring T, et al. Methods to monitor distribution and metabolic activity of mesenchymal stem cells following in vivo injection into nucleotomized porcine intervertebral discs. Eur Spine J. 2010;19:601-12 pubmed publisher
    ..Therefore, IVD-regeneration-strategies should increasingly focus on annulus reconstruction in order to reduce implant loss due to annular failure. ..
  77. Huang Y, Zhang C, Huang T, Huang W, Huang X. [Efficacy of a domestic left-disk-coated atrial septal occluder on treating patent foramen Ovale in a miniswine model]. Zhonghua Xin Xue Guan Bing Za Zhi. 2009;37:936-8 pubmed
    ..Satisfactory biocompatibility, rapid and complete endothelium covering and low incidence of complication are also evidenced for this closure system in our experiment. ..
  78. Itoh Y, Shimazu A, Sadzuka Y, Sonobe T, Itai S. Novel method for stratum corneum pore size determination using positron annihilation lifetime spectroscopy. Int J Pharm. 2008;358:91-5 pubmed publisher
    ..5-0.8 nm and a torus height of 0.79 nm. Positron annihilation spectroscopy may be developed as a new technique for the detection of nano-pore properties and free volume in the biological sciences. ..
  79. Yamamoto H, Li T, Koshimoto C, Ito K, Kita M, Miyashita N, et al. Serological evidence for hepatitis e virus infection in laboratory monkeys and pigs in animal facilities in Japan. Exp Anim. 2008;57:367-76 pubmed
    ..1%) of farm pigs was much higher than that of monkeys (0.8%). These results suggest the relative levels of risk of HEV infection from these animals to animal handlers and researchers who work with them in laboratory animal facilities. ..
  80. Moskalenko V, Hüller M, Gasser M, Demidchik Y, Thiede A, Timm S, et al. Investigation of the regeneration potential of the recurrent laryngeal nerve (RLN) after compression injury, using neuromonitoring. Langenbecks Arch Surg. 2009;394:469-74 pubmed publisher
    ..The acute compression of RLN can only be detected by observing the amplitude of the neuromonitoring signal. Restitutio ad integrum is possible after a short clamping period but it is important to preserve the RLN continuity. ..
  81. Navarro R, Oltramari Navarro P, Sant Ana E, Henriques J, Taga R, Cestari T, et al. Histologic and tomographic analyses of the temporomandibular joint after mandibular advancement surgery: study in minipigs. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;107:477-84 pubmed publisher
    ..The results indicated that bicortical screw fixation resulted in more pronounced condylar alterations in the shape of the condyles than miniplate osteosynthesis. However, further clinical studies are necessary to confirm these data. ..
  82. Osipov R, Robich M, Feng J, Clements R, Liu Y, Glazer H, et al. Effect of thrombin fragment (TP508) on myocardial ischemia-reperfusion injury in hypercholesterolemic pigs. J Appl Physiol (1985). 2009;106:1993-2001 pubmed publisher
    ..05). This study demonstrates that, in hypercholesterolemic pigs, TP508 decreases myocardial necrosis and apoptosis after IR. Thus TP508 may offer a novel approach in protecting the myocardium from IR injury. ..
  83. Hiebl B, Mrowietz C, Braune S, Franke R, Plendl J, Jung F. Intravital microscopy of the capillary perfusion in the corium limbi of the third toe of the minipig. Clin Hemorheol Microcirc. 2009;43:173-9 pubmed publisher
    ..No differences in capillary circulation were found. The present method is thus very well suited for long-term microcirculation measurements in pigs, e.g., to evaluate therapeutic interventions in the ischemic limb model. ..
  84. Hishikawa S, Kawano M, Tanaka H, Konno K, Yasuda Y, Kawano R, et al. Mannequin simulation improves the confidence of medical students performing tube thoracostomy: a prospective, controlled trial. Am Surg. 2010;76:73-8 pubmed
    ..Further trials may be needed to delineate the optimal role for these simulators in teaching tube thoracostomy. ..
  85. Xu J, Yan X, Gao R, Mao L, Cotrim A, Zheng C, et al. Effect of irradiation on microvascular endothelial cells of parotid glands in the miniature pig. Int J Radiat Oncol Biol Phys. 2010;78:897-903 pubmed publisher
    ..The significant and rapid increases of ASMase and NSMase activity levels may be important in this IR-induced damage. ..
  86. Kuo Y, Shih H, Lin C, Huang C, Yang J, Wu W, et al. Swine hemi-facial composite tissue allotransplantation: a model to study immune rejection. J Surg Res. 2009;153:268-73 pubmed publisher
    ..Eleven out-bred miniature swine underwent hemi-facial transplant...
  87. Leroy J, Cahill R, Peretta S, Marescaux J. Single port sigmoidectomy in an experimental model with survival. Surg Innov. 2008;15:260-5 pubmed publisher
    ..As an operative approach, it may both advance in its own right as much as facilitate the evolution and clinical incorporation of other developmental access routes. ..
  88. van Beusekom H, Sorop O, Weymaere M, Duncker D, van der Giessen W. The neointimal response to stents eluting tacrolimus from a degradable coating depends on the balance between polymer degradation and drug release. EuroIntervention. 2008;4:139-47 pubmed
    ..Tacrolimus eluted from a biodegradable stent coating can suppress the inflammatory effect of the coating degradation products if the balance between the drug levels and the degradation products is favorable. ..
  89. Avison D, DeFaria W, Tryphonopoulos P, Tekin A, Attia G, Takahashi H, et al. Heterotopic uterus transplantation in a swine model. Transplantation. 2009;88:465-9 pubmed publisher
    ..These findings demonstrate that successful uterus transplantation in a large animal model (miniature swine) is feasible using this heterotopic model, and it can be useful for the study of these transplants.
  90. Golbar H, Izawa T, Kuwamura M, Ito S, Yamate J. Uterine adenocarcinoma with prominent desmoplasia in a geriatric miniature pig. J Vet Med Sci. 2010;72:253-6 pubmed
    ..Metastatic lesions were seen in the lungs and liver. Based on these findings, a diagnosis of uterine adenocarcinoma with marked desmoplasia was made. This case is the second report of uterine adenocarcinoma in the miniature pig. ..
  91. Kotsougiani D, Hundepool C, Bulstra L, Friedrich P, Shin A, Bishop A. Recipient-derived angiogenesis with short term immunosuppression increases bone remodeling in bone vascularized composite allotransplantation: A pilot study in a swine tibial defect model. J Orthop Res. 2017;35:1242-1249 pubmed publisher
    ..A segmental tibial defect was reconstructed in Yucatan miniature swine by transplantation of a matched tibia segment from an immunologically mismatched donor...
  92. Pascale F, Pascale F, Contreras V, Bonneau M, Courbet A, Chilmonczyk S, et al. Plasmacytoid dendritic cells migrate in afferent skin lymph. J Immunol. 2008;180:5963-72 pubmed
    ..Thus, pDC can link innate and acquired immunity by migrating from tissue to draining node via lymph, similarly to conventional dendritic cells. ..