takifugu

Summary

Summary: A genus of pufferfish commonly used for research.

Top Publications

  1. Zou J, Yoshiura Y, Dijkstra J, Sakai M, Ototake M, Secombes C. Identification of an interferon gamma homologue in Fugu, Takifugu rubripes. Fish Shellfish Immunol. 2004;17:403-9 pubmed
  2. Kato A, Muro T, Kimura Y, Li S, Islam Z, Ogoshi M, et al. Differential expression of Na+-Cl- cotransporter and Na+-K+-Cl- cotransporter 2 in the distal nephrons of euryhaline and seawater pufferfishes. Am J Physiol Regul Integr Comp Physiol. 2011;300:R284-97 pubmed publisher
    ..in the distal tubules and NCC was highly expressed in the collecting ducts of euryhaline pufferfish (mefugu, Takifugu obscurus)...
  3. Yu W, Brenner S, Venkatesh B. Duplication, degeneration and subfunctionalization of the nested synapsin-Timp genes in Fugu. Trends Genet. 2003;19:180-3 pubmed publisher
  4. Nawata C, Hirose S, Nakada T, Wood C, Kato A. Rh glycoprotein expression is modulated in pufferfish (Takifugu rubripes) during high environmental ammonia exposure. J Exp Biol. 2010;213:3150-60 pubmed publisher
    ..Passive processes and/or Rhbg and Rhcg2 in the pavement cells may maintain basal levels of plasma ammonia but elevated levels may require active excretion via NKA and Rhcg1 in the MRCs. ..
  5. Sambrook J, Campbell R, Elgar G. Characterisation of a gene cluster in Fugu rubripes containing the complement component C4 gene. Gene. 2003;312:73-83 pubmed
    ..All of the six identified Fugu MHC-related genes have been characterised at the genomic level...
  6. Yamamori K, Kono M, Furukawa K, Matsui T. [The toxification of juvenile cultured kusafugu Takifugu niphobles by oral administration of crystalline tetrodotoxin]. Shokuhin Eiseigaku Zasshi. 2004;45:73-5 pubmed
    ..With administration of crystalline TTX, all kusafugu used in the experiment became toxic and retained the toxin at the level of 30% of the administered toxin for about 5 months thereafter, while being fed with non-toxic diet. ..
  7. Smith S, Snell P, Gruetzner F, Bench A, Haaf T, Metcalfe J, et al. Analyses of the extent of shared synteny and conserved gene orders between the genome of Fugu rubripes and human 20q. Genome Res. 2002;12:776-84 pubmed
  8. Udvadia A. 3.6 kb genomic sequence from Takifugu capable of promoting axon growth-associated gene expression in developing and regenerating zebrafish neurons. Gene Expr Patterns. 2008;8:382-8 pubmed publisher
    ..In addition, this sequence will also be useful for targeting gene expression to neurons during periods of growth and plasticity. ..
  9. Lu J, Chen H, Xu Q, Zheng J, Liu H, Li J, et al. Comparative proteomics of kidney samples from puffer fish Takifugu rubripes exposed to excessive fluoride: an insight into molecular response to fluorosis. Toxicol Mech Methods. 2010;20:345-54 pubmed publisher
    ..will greatly advance one's understanding of the effects of fluoride exposure on the physiological and biochemical functions of takifugu kidney as well as the toxicological mechanism of fluoride-causing fluorosis in both fish and humans.

More Information

Publications101 found, 100 shown here

  1. Kato A, Doi H, Nakada T, Sakai H, Hirose S. Takifugu obscurus is a euryhaline fugu species very close to Takifugu rubripes and suitable for studying osmoregulation. BMC Physiol. 2005;5:18 pubmed
    The genome sequence of the pufferfish Takifugu rubripes is an enormously useful tool in the molecular physiology of fish...
  2. Ikeda K, Murakami Y, Emoto Y, Ngy L, Taniyama S, Yagi M, et al. Transfer profile of intramuscularly administered tetrodotoxin to non-toxic cultured specimens of the pufferfish Takifugu rubripes. Toxicon. 2009;53:99-103 pubmed publisher
    Tetrodotoxin (TTX) was intramuscularly administered to non-toxic cultured specimens of the pufferfish Takifugu rubripes to investigate TTX transfer/accumulation profiles in the pufferfish body...
  3. Kimura Yoshida C, Kitajima K, Oda Ishii I, Tian E, Suzuki M, Yamamoto M, et al. Characterization of the pufferfish Otx2 cis-regulators reveals evolutionarily conserved genetic mechanisms for vertebrate head specification. Development. 2004;131:57-71 pubmed publisher
    ..Therefore, we propose that, in vertebrate evolution, the Otx2 promoter acquires multiple, spatiotemporally specific cis-regulators in order to precisely control highly coordinated processes in head development...
  4. Ito K, Okabe S, Asakawa M, Bessho K, Taniyama S, Shida Y, et al. Detection of tetrodotoxin (TTX) from two copepods infecting the grass puffer Takifugu niphobles: TTX attracting the parasites?. Toxicon. 2006;48:620-6 pubmed
    ..were collected from the body surface and gill of the grass puffer Takifugu niphobles, respectively, in Takehara city, Hiroshima Prefecture, faced with Seto Inland Sea located in the ..
  5. Motohashi E, Hamabata T, Ando H. Structure of neurohypophysial hormone genes and changes in the levels of expression during spawning season in grass puffer (Takifugu niphobles). Gen Comp Endocrinol. 2008;155:456-63 pubmed
    ..Additionally, much less is known about roles of isotocin (IT) in regulation of behavior. Grass puffer, Takifugu niphobles, has unique spawning behavior; spawning occurs on beach only for several days around the spring tide ..
  6. Kono T, Bird S, Sonoda K, Savan R, Secombes C, Sakai M. Characterization and expression analysis of an interleukin-7 homologue in the Japanese pufferfish, Takifugu rubripes. FEBS J. 2008;275:1213-26 pubmed publisher
    An interleukin-7 (IL-7) gene has been cloned and sequenced within the Japanese pufferfish, Takifugu rubripes (Fugu), providing the first conclusive evidence for the existence of IL-7 in teleosts...
  7. Bellingham J, Tarttelin E, Foster R, Wells D. Structure and evolution of the teleost extraretinal rod-like opsin (errlo) and ocular rod opsin (rho) genes: is teleost rho a retrogene?. J Exp Zool B Mol Dev Evol. 2003;297:1-10 pubmed
    ..opsin (exo-rhodopsin) gene, errlo (which is expressed uniquely in the pineal), in the puffer-fish, Fugu rubripes (Takifugu rubripes)...
  8. Van de Peer Y. Tetraodon genome confirms Takifugu findings: most fish are ancient polyploids. Genome Biol. 2004;5:250 pubmed
    An evolutionary hypothesis suggested by studies of the genome of the tiger pufferfish Takifugu rubripes has now been confirmed by comparison with the genome of a close relative, the spotted green pufferfish Tetraodon nigroviridis...
  9. Woolfe A, Goodson M, Goode D, Snell P, McEwen G, Vavouri T, et al. Highly conserved non-coding sequences are associated with vertebrate development. PLoS Biol. 2005;3:e7 pubmed
    ..These highly conserved non-coding sequences are likely to form part of the genomic circuitry that uniquely defines vertebrate development. ..
  10. Tümpel S, Cambronero F, Wiedemann L, Krumlauf R. Evolution of cis elements in the differential expression of two Hoxa2 coparalogous genes in pufferfish (Takifugu rubripes). Proc Natl Acad Sci U S A. 2006;103:5419-24 pubmed
    ..There is a single Hoxa2 gene in most vertebrates, whereas fugu (Takifugu rubripes) and medaka (Oryzias latipes) have two coparalogous genes [Hoxa2(a) and Hoxa2(b)]...
  11. Jang J, Yotsu Yamashita M. 6,11-Dideoxytetrodotoxin from the puffer fish, Fugu pardalis. Toxicon. 2007;50:947-51 pubmed
    ..We also roughly determined the value of IC(50) (mice, intraperitoneal) for 6,11-dideoxytetrodotoxin as 420 microg/kg and thus it is 42 times less toxic than tetrodotoxin. ..
  12. Yu W, Rajasegaran V, Yew K, Loh W, Tay B, Amemiya C, et al. Elephant shark sequence reveals unique insights into the evolutionary history of vertebrate genes: A comparative analysis of the protocadherin cluster. Proc Natl Acad Sci U S A. 2008;105:3819-24 pubmed publisher
    ..The small and "stable" genome of the elephant shark is a valuable reference for understanding the evolution of vertebrate genomes...
  13. Spitz F, Gonzalez F, Duboule D. A global control region defines a chromosomal regulatory landscape containing the HoxD cluster. Cell. 2003;113:405-17 pubmed
    ..These domains were interrupted in the Ulnaless mutation, a balanced inversion that modified the topography of the locus. We discuss the heuristic value of these results in term of locus specific versus gene-specific regulation. ..
  14. Tada M, Senzaki K, Tai Y, Morishita H, Tanaka Y, Murata Y, et al. Genomic organization and transcripts of the zebrafish Protocadherin genes. Gene. 2004;340:197-211 pubmed
    ..Thus, although the Pcdhalpha families were common to diverse vertebrates, their gene number, structure, and transcripts were different between teleosts and mammals. ..
  15. Nakada T, Westhoff C, Kato A, Hirose S. Ammonia secretion from fish gill depends on a set of Rh glycoproteins. FASEB J. 2007;21:1067-74 pubmed
    ..We identified the Rh glycoprotein homologs, fRhag, fRhbg, fRhcg1, and fRhcg2, of the pufferfish, Takifugu rubripes...
  16. Imai S, Sasaki T, Shimizu A, Asakawa S, Hori H, Shimizu N. The genome size evolution of medaka (Oryzias latipes) and fugu (Takifugu rubripes). Genes Genet Syst. 2007;82:135-44 pubmed
    ..In this study, we compared the genomic DNA sequences of two kinds of fish, medaka (Oryzias latipes) and fugu (Takifugu rubripes), which show two-fold difference in the genome size (800 Mb vs. 400 Mb)...
  17. Yamanoue Y, Miya M, Matsuura K, Miyazawa S, Tsukamoto N, Doi H, et al. Explosive speciation of Takifugu: another use of fugu as a model system for evolutionary biology. Mol Biol Evol. 2009;26:623-9 pubmed publisher
    Although the fugu Takifugu rubripes has attracted attention as a model organism for genomic studies because of its compact genome, it is not generally appreciated that there are approximately 25 closely related species with limited ..
  18. Li M, Li Y, Lu L, Wang X, Gong Q, Duan C. Structural, gene expression, and functional analysis of the fugu (Takifugu rubripes) insulin-like growth factor binding protein-4 gene. Am J Physiol Regul Integr Comp Physiol. 2009;296:R558-66 pubmed publisher
    ..These results provide new information about the structural and functional conservation, expression patterns, and physiological regulation of the IGFBP-4 gene in a teleost fish...
  19. Brenner S, Venkatesh B, Yap W, Chou C, Tay A, Ponniah S, et al. Conserved regulation of the lymphocyte-specific expression of lck in the Fugu and mammals. Proc Natl Acad Sci U S A. 2002;99:2936-41 pubmed publisher
    ..The short promoter of the Fugu lck isolated by us offers a powerful tool for labeling T cells, targeting expression, and manipulating T cell activity in fishes as well as in mammals...
  20. Taylor J, Braasch I, Frickey T, Meyer A, Van de Peer Y. Genome duplication, a trait shared by 22000 species of ray-finned fish. Genome Res. 2003;13:382-90 pubmed
    ..For 22 of these genes, both zebrafish duplicates had orthologs in the pufferfish (Takifugu rubripes)...
  21. Nobrega M, Ovcharenko I, Afzal V, Rubin E. Scanning human gene deserts for long-range enhancers. Science. 2003;302:413 pubmed
  22. Fredriksson R, Höglund P, Gloriam D, Lagerström M, Schioth H. Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. FEBS Lett. 2003;554:381-8 pubmed
    ..Several ESTs for GPR141 were found in marrow and cancer cells, while the other receptors seem to have more restricted expression patterns. ..
  23. Jabbari K, Bernardi G. Body temperature and evolutionary genomics of vertebrates: a lesson from the genomes of Takifugu rubripes and Tetraodon nigroviridis. Gene. 2004;333:179-81 pubmed
    ..The higher body temperature of Tetraodon nigroviridis compared to Takifugu rubripes (DeltaT approximately 15 degrees C) appears to be the cause of a higher compositional heterogeneity of ..
  24. Alioto T, Ngai J. The odorant receptor repertoire of teleost fish. BMC Genomics. 2005;6:173 pubmed
    ..In addition, our calculations of the ratios of non-synonymous to synonymous codon substitutions among more recently expanding OR subgroups in zebrafish implicate residues that may be involved in odorant binding. ..
  25. Pennacchio L, Ahituv N, Moses A, Prabhakar S, Nobrega M, Shoukry M, et al. In vivo enhancer analysis of human conserved non-coding sequences. Nature. 2006;444:499-502 pubmed
    ..activity of a large group of non-coding elements in the human genome that are conserved in human-pufferfish, Takifugu (Fugu) rubripes, or ultraconserved in human-mouse-rat...
  26. Gillemans N, McMorrow T, Tewari R, Wai A, Burgtorf C, Drabek D, et al. Functional and comparative analysis of globin loci in pufferfish and humans. Blood. 2003;101:2842-9 pubmed publisher
    ..This provides evidence that duplication of the globin loci has occurred several times during evolution, resulting in the 5 human globin loci known to date, each encoding proteins with specific functions in specific cell types...
  27. Clark M, Edwards Y, Peterson D, Clifton S, Thompson A, Sasaki M, et al. Fugu ESTs: new resources for transcription analysis and genome annotation. Genome Res. 2003;13:2747-53 pubmed
    ..This is particularly timely with the increasing availability of draft genome sequence from different organisms and the mounting emphasis on gene function and regulation. ..
  28. Balesaria S, Hogstrand C. Identification, cloning and characterization of a plasma membrane zinc efflux transporter, TrZnT-1, from fugu pufferfish (Takifugu rubripes). Biochem J. 2006;394:485-93 pubmed publisher
    ..of the mammalian ZnT-1 (zinc transporter-1) gene was cloned from the intestine of the torafugu pufferfish (Takifugu rubripes), demonstrating that this gene predates the evolution of land-living vertebrates. TrZnT-1 (T...
  29. Akolkar D, Kinoshita S, Yasmin L, Ono Y, Ikeda D, Yamaguchi H, et al. Fibre type-specific expression patterns of myosin heavy chain genes in adult torafugu Takifugu rubripes muscles. J Exp Biol. 2010;213:137-45 pubmed publisher
    ..studies, based on the total fugu genome database, which was the first to appear in fish, revealed that torafugu Takifugu rubripes contains 20 sarcomeric myosin heavy chain (MYH) genes (MYH genes) (Ikeda et al., 2007)...
  30. Kurokawa T, Uji S, Suzuki T. Identification of cDNA coding for a homologue to mammalian leptin from pufferfish, Takifugu rubripes. Peptides. 2005;26:745-50 pubmed publisher
    We identified cDNA coding for a homologue to mammalian leptin in puffer, Takifugu rubripes, using genomic synteny around the human leptin gene...
  31. Korenaga H, Kono T, Sakai M. Isolation of seven IL-17 family genes from the Japanese pufferfish Takifugu rubripes. Fish Shellfish Immunol. 2010;28:809-18 pubmed publisher
    ..Moreover, expression of IL-17 family genes was significantly up-regulated in the lipopolysaccharide-stimulated head kidney. These results suggested that Fugu IL-17 family members were involved in inflammatory responses...
  32. Hedges S, Kumar S. Genomics. Vertebrate genomes compared. Science. 2002;297:1283-5 pubmed
  33. Jones A, Elgar G, Sattelle D. The nicotinic acetylcholine receptor gene family of the pufferfish, Fugu rubripes. Genomics. 2003;82:441-51 pubmed
    ..We show, using RT-PCR, that the Fugu nAChR subunits are expressed in a variety of tissues...
  34. Klovins J, Haitina T, Fridmanis D, Kilianova Z, Kapa I, Fredriksson R, et al. The melanocortin system in Fugu: determination of POMC/AGRP/MCR gene repertoire and synteny, as well as pharmacology and anatomical distribution of the MCRs. Mol Biol Evol. 2004;21:563-79 pubmed publisher
    ..We performed a comprehensive characterization of the MC system in Fugu (Takifugu rubripes)...
  35. Cardoso J, Power D, Elgar G, Clark M. Duplicated receptors for VIP and PACAP (VPAC1R and PAC1R) in a teleost fish, Fugu rubripes. J Mol Endocrinol. 2004;33:411-28 pubmed publisher
    ..3 and also C. elegans chromosome X, indicating that the putative ancestral human chromosome 3 region may be equivalent to chromosome X in Caenorhabditis elegans...
  36. Kai W, Kikuchi K, Fujita M, Suetake H, Fujiwara A, Yoshiura Y, et al. A genetic linkage map for the tiger pufferfish, Takifugu rubripes. Genetics. 2005;171:227-38 pubmed
    The compact genome of the tiger pufferfish, Takifugu rubripes (fugu), has been sequenced to the "draft" level and annotated to identify all the genes...
  37. Dehal P, Boore J. Two rounds of whole genome duplication in the ancestral vertebrate. PLoS Biol. 2005;3:e314 pubmed
    ..Our results highlight the potential for these large-scale genomic events to have driven the evolutionary success of the vertebrate lineage...
  38. Vavouri T, McEwen G, Woolfe A, Gilks W, Elgar G. Defining a genomic radius for long-range enhancer action: duplicated conserved non-coding elements hold the key. Trends Genet. 2006;22:5-10 pubmed
    ..This enables us to provide the first systematic estimate of the genomic range for distal cis-regulatory interactions in the human genome: half of CNEs are >250 kb away from their associated gene...
  39. Kikuchi K, Kai W, Hosokawa A, Mizuno N, Suetake H, Asahina K, et al. The sex-determining locus in the tiger pufferfish, Takifugu rubripes. Genetics. 2007;175:2039-42 pubmed
    The tiger pufferfish (fugu), Takifugu rubripes, is a model fish that has had its genome entirely sequenced...
  40. Matsumoto T, Nagashima Y, Kusuhara H, Ishizaki S, Shimakura K, Shiomi K. Pharmacokinetics of tetrodotoxin in puffer fish Takifugu rubripes by a single administration technique. Toxicon. 2008;51:1051-9 pubmed publisher
    ..In this study, we examined the pharmacokinetics of TTX in Takifugu rubripes by a single administration under general anesthesia at 20 degrees C for 300 min...
  41. Montoya Burgos J. Patterns of positive selection and neutral evolution in the protein-coding genes of Tetraodon and Takifugu. PLoS ONE. 2011;6:e24800 pubmed publisher
    ..I have investigated the selective pressure acting on protein-coding genes of the puffer fishes Tetraodon and Takifugu. My results indicate that the strength of purifying selection in puffer fishes is similar to previous reports for ..
  42. Aparicio S, Chapman J, Stupka E, Putnam N, Chia J, Dehal P, et al. Whole-genome shotgun assembly and analysis of the genome of Fugu rubripes. Science. 2002;297:1301-10 pubmed
    ..Conserved linkages between Fugu and human genes indicate the preservation of chromosomal segments from the common vertebrate ancestor, but with considerable scrambling of gene order...
  43. Oshiumi H, Tsujita T, Shida K, Matsumoto M, Ikeo K, Seya T. Prediction of the prototype of the human Toll-like receptor gene family from the pufferfish, Fugu rubripes, genome. Immunogenetics. 2003;54:791-800 pubmed publisher
    ..We interpret the present data to mean that the differences of TLRs identified in this study between fishes and humans may be rather peripheral, partially due to selection pressure exerted by pathogens in distinct environments...
  44. Zimek A, Stick R, Weber K. Genes coding for intermediate filament proteins: common features and unexpected differences in the genomes of humans and the teleost fish Fugu rubripes. J Cell Sci. 2003;116:2295-302 pubmed publisher
    ..Most correspond to additional introns in the fish genes. A search for genes encoding nuclear lamins reveals the four established fish lamins (A, B1, B2 and LIII) as well as an unexpected second lamin A...
  45. Hikima J, Lennard M, Wilson M, Miller N, Clem L, Warr G. Evolution of vertebrate E protein transcription factors: comparative analysis of the E protein gene family in Takifugu rubripes and humans. Physiol Genomics. 2005;21:144-51 pubmed publisher
    ..Here we sought to define the complete family of E protein genes in a teleost fish, Takifugu rubripes, taking advantage of the completed genome sequence...
  46. Fernandes J, Mackenzie M, Elgar G, Suzuki Y, Watabe S, Kinghorn J, et al. A genomic approach to reveal novel genes associated with myotube formation in the model teleost, Takifugu rubripes. Physiol Genomics. 2005;22:327-38 pubmed
    ..approach to discover novel genes associated with myotube formation in fast muscle of the tiger puffer fish, Takifugu rubripes. The number of fast muscle fibers per myotome increased until 1...
  47. Ishimaru Y, Okada S, Naito H, Nagai T, Yasuoka A, Matsumoto I, et al. Two families of candidate taste receptors in fishes. Mech Dev. 2005;122:1310-21 pubmed publisher
    ..These results suggest that vertebrates commonly have two kinds of taste signaling pathways that are defined by the types of taste receptors expressed in taste receptor cells...
  48. Yu W, Yew K, Rajasegaran V, Venkatesh B. Sequencing and comparative analysis of fugu protocadherin clusters reveal diversity of protocadherin genes among teleosts. BMC Evol Biol. 2007;7:49 pubmed
    ..To gain further insight into the evolutionary history of protocadherin clusters, we have sequenced and analyzed protocadherin clusters from the compact genome of the pufferfish, Fugu rubripes...
  49. Suetake H, Araki K, Akatsu K, Somamoto T, Dijkstra J, Yoshiura Y, et al. Genomic organization and expression of CD8alpha and CD8beta genes in fugu Takifugu rubripes. Fish Shellfish Immunol. 2007;23:1107-18 pubmed publisher
    We have cloned cDNAs encoding the alpha and beta chains of CD8 from the tiger pufferfish (fugu), Takifugu rubripes...
  50. Araki K, Akatsu K, Suetake H, Kikuchi K, Suzuki Y. Characterization of CD8+ leukocytes in fugu (Takifugu rubripes) with antiserum against fugu CD8alpha. Dev Comp Immunol. 2008;32:850-8 pubmed publisher
    ..This result suggests that similar to mammalian dendritic cells, fugu monocytes/macrophages express CD8alpha...
  51. Griffin C, Kleinjan D, Doe B, van Heyningen V. New 3' elements control Pax6 expression in the developing pretectum, neural retina and olfactory region. Mech Dev. 2002;112:89-100 pubmed
  52. Zhang T, Tan Y, Fu J, Lui D, Ning Y, Jirik F, et al. The regulation of retina specific expression of rhodopsin gene in vertebrates. Gene. 2003;313:189-200 pubmed
    ..Our investigation suggests that the regulation of retinal specific expression is conserved in the pufferfish, frog and mouse and that the ancestral intron-containing rhodopsin gene has been displaced by an intronless copy in teleosts...
  53. Cardoso J, Power D, Elgar G, Clark M. Isolation and characterisation of the corticotropin releasing factor receptor 1 (CRFR1) gene in a teleost fish, Fugu rubripes. DNA Seq. 2003;14:215-8 pubmed
    ..In vertebrates this receptor appears to have a different tissue distribution and its presence in the gills may indicate a new role in osmoregulatory processes...
  54. Sibthorpe D, Baker A, Gilmartin B, Blackwell J, White J. Comparative analysis of two slc11 (Nramp) loci in Takifugu rubripes. DNA Cell Biol. 2004;23:45-58 pubmed publisher
    ..carrier family 11 (slc11; formerly Nramp) protein, we isolated and characterized two paralogs from the pufferfish Takifugu rubripes (Fugu)...
  55. Fredriksson R, Schioth H. The repertoire of G-protein-coupled receptors in fully sequenced genomes. Mol Pharmacol. 2005;67:1414-25 pubmed
    ..We also provide searchable data sets that may be used for annotation and further detailed analysis of the GPCR family. This study provides an extensive overview of the expansion of the gene repertoire for families and subgroups of GPCRs...
  56. Kurokawa T, Murashita K, Uji S. Characterization and tissue distribution of multiple agouti-family genes in pufferfish, Takifugu rubripes. Peptides. 2006;27:3165-75 pubmed publisher
    Four types of agouti-family genes (AGRP1, AGRP2, ASIP1 and ASIP2) were obtained from torafugu, Takifugu rubripes. Their characterization and structure were analyzed to elucidate the relationship among the torafugu agouti-family genes...
  57. Ohtani M, Miyadai T. Functional analysis of fish BCL-6 and Blimp-1 in vitro: transcriptional repressors for B-cell terminal differentiation in fugu (Takifugu rubripes). Mol Immunol. 2011;48:818-25 pubmed publisher
    ..We have previously identified the BCL-6 gene and Blimp-1 gene in fugu (Takifugu rubripes)...
  58. Kai W, Kikuchi K, Tohari S, Chew A, Tay A, Fujiwara A, et al. Integration of the genetic map and genome assembly of fugu facilitates insights into distinct features of genome evolution in teleosts and mammals. Genome Biol Evol. 2011;3:424-42 pubmed publisher
    The compact genome of fugu (Takifugu rubripes) has been used widely as a reference genome for understanding the evolution of vertebrate genomes...
  59. Wang J, Araki T, Tatsuno R, Nina S, Ikeda K, Hamasaki M, et al. Transfer profile of intramuscularly administered tetrodotoxin to artificial hybrid specimens of pufferfish, Takifugu rubripes and Takifugu niphobles. Toxicon. 2011;58:565-9 pubmed publisher
    Tetrodotoxin (TTX) was intramuscularly administered to artificially hybridized specimens of the pufferfish Takifugu rubripes and Takifugu niphobles to investigate toxin accumulation in hybrids, and TTX transfer/accumulation profiles in ..
  60. Gilligan P, Brenner S, Venkatesh B. Fugu and human sequence comparison identifies novel human genes and conserved non-coding sequences. Gene. 2002;294:35-44 pubmed
    ..This study confirms the utility of the Fugu as a supplementary tool to uncover and confirm novel genes and putative gene regulatory regions in the human genome...
  61. Ghanem N, Jarinova O, Amores A, Long Q, Hatch G, Park B, et al. Regulatory roles of conserved intergenic domains in vertebrate Dlx bigene clusters. Genome Res. 2003;13:533-43 pubmed
    ..the Dlx5/Dlx6 intergenic regions from human, mouse, zebrafish, and from two pufferfish, Spheroides nephelus and Takifugu rubripes...
  62. Bejerano G, Pheasant M, Makunin I, Stephen S, Kent W, Mattick J, et al. Ultraconserved elements in the human genome. Science. 2004;304:1321-5 pubmed
  63. Itoi S, Misaki R, Hirayama M, Nakaniwa M, Liang C, Kondo H, et al. Identification of three isoforms for mitochondrial adenine nucleotide translocator in the pufferfish Takifugu rubripes. Mitochondrion. 2005;5:162-72 pubmed publisher
    ..mining of the Fugu genome database along with isolation of their corresponding cDNAs in vivo from the pufferfish (Takifugu rubripes)...
  64. Matsumoto T, Nagashima Y, Kusuhara H, Sugiyama Y, Ishizaki S, Shimakura K, et al. Involvement of carrier-mediated transport system in uptake of tetrodotoxin into liver tissue slices of puffer fish Takifugu rubripes. Toxicon. 2007;50:173-9 pubmed
    ..In the present study, uptake of TTX into the liver tissue slices of puffer fish Takifugu rubripes was investigated by in vitro incubation experiment. When T...
  65. Kondo H, Misaki R, Gelman L, Watabe S. Ligand-dependent transcriptional activities of four torafugu pufferfish Takifugu rubripes peroxisome proliferator-activated receptors. Gen Comp Endocrinol. 2007;154:120-7 pubmed
    ..receptors (PPARs), PPARalpha1, PPARalpha2, PPARbeta, and PPARgamma, from torafugu pufferfish Takifugu rubripes and determined for their transcriptional activity by the reporter assay using reporter plasmids ..
  66. Maran B, Iwamoto E, Okuda J, Matsuda S, Taniyama S, Shida Y, et al. Isolation and characterization of bacteria from the copepod Pseudocaligus fugu ectoparasitic on the panther puffer Takifugu pardalis with the emphasis on TTX. Toxicon. 2007;50:779-90 pubmed
    ..the copepod Pseudocaligus fugu, which is a common parasite, collected from the body surface of the panther puffer Takifugu pardalis...
  67. Christen B, Wuthrich K, Hornemann S. Putative prion protein from Fugu (Takifugu rubripes). FEBS J. 2008;275:263-70 pubmed
  68. Lee K, Yamaguchi A, Rashid H, Kadomura K, Yasumoto S, Matsuyama M. Estradiol-17beta treatment induces intersexual gonadal development in the pufferfish, Takifugu rubripes. Zoolog Sci. 2009;26:639-45 pubmed publisher
    ..Artificial estradiol-17beta (E2) treatment Induces sex reversal in some fish. The Japanese pufferfish (Takifugu rubripes) has the most compact genome among vertebrates and great pottial for comparative genome analysis...
  69. Kamiya T, Kai W, Tasumi S, Oka A, Matsunaga T, Mizuno N, et al. A trans-species missense SNP in Amhr2 is associated with sex determination in the tiger pufferfish, Takifugu rubripes (fugu). PLoS Genet. 2012;8:e1002798 pubmed publisher
    ..By linkage and association mapping of the SD locus in fugu (Takifugu rubripes), we show that a SNP (C/G) in the anti-Müllerian hormone receptor type II (Amhr2) gene is the only ..
  70. Eggers J, Stock M, Fliegauf M, Vonderstrass B, Otto F. Genomic characterization of the RUNX2 gene of Fugu rubripes. Gene. 2002;291:159-67 pubmed
    ..Three further conserved non-coding regions were identified possibly functioning as enhancer elements for tissue-specific expression of RUNX2...
  71. Williams H, Brenner S, Venkatesh B. Identification and analysis of additional copies of the platelet-derived growth factor receptor and colony stimulating factor 1 receptor genes in fugu. Gene. 2002;295:255-64 pubmed
    ..These results are discussed in the context of the proposed teleost lineage-specific whole genome duplication hypothesis...
  72. Maglich J, Caravella J, Lambert M, Willson T, Moore J, Ramamurthy L. The first completed genome sequence from a teleost fish (Fugu rubripes) adds significant diversity to the nuclear receptor superfamily. Nucleic Acids Res. 2003;31:4051-8 pubmed
    ..All of the Fugu receptors that were analyzed by PCR in this study were expressed, indicating that the majority of the additional Fugu receptors are likely to be functional...
  73. Christoffels A, Koh E, Chia J, Brenner S, Aparicio S, Venkatesh B. Fugu genome analysis provides evidence for a whole-genome duplication early during the evolution of ray-finned fishes. Mol Biol Evol. 2004;21:1146-51 pubmed
    ..These data strongly suggest a whole-genome duplication event early during the evolution of ray-finned fishes, probably before the origin of teleosts...
  74. Kurokawa T, Uji S, Suzuki T. Identification of pepsinogen gene in the genome of stomachless fish, Takifugu rubripes. Comp Biochem Physiol B Biochem Mol Biol. 2005;140:133-40 pubmed publisher
    ..So whether puffer have pepsinogen gene or not is an interesting issue. A search of GSS database for pufferfish, Takifugu rubripes, revealed five different aspartic proteinase genes in its genome...
  75. Tanaka M, Hale L, Amores A, Yan Y, Cresko W, Suzuki T, et al. Developmental genetic basis for the evolution of pelvic fin loss in the pufferfish Takifugu rubripes. Dev Biol. 2005;281:227-39 pubmed
    ..mechanisms? To determine the developmental genetic basis for the evolution of pelvis loss in the pufferfish Takifugu rubripes (fugu), we isolated fugu orthologs of genes thought to be essential for limb development in tetrapods, ..
  76. Lee K, Kaneko T, Aida K. Prolactin and prolactin receptor expressions in a marine teleost, pufferfish Takifugu rubripes. Gen Comp Endocrinol. 2006;146:318-28 pubmed publisher
    To investigate the physiological significance of prolactin (PRL) in a marine teleost, pufferfish (or fugu), Takifugu rubripes, we cloned and characterized cDNAs encoding its PRL and PRL receptor (PRLR) from the pituitary and gills, ..
  77. Motohashi E, Hasegawa S, Mishiro K, Ando H. Osmoregulatory responses of expression of vasotocin, isotocin, prolactin and growth hormone genes following hypoosmotic challenge in a stenohaline marine teleost, tiger puffer (Takifugu rubripes). Comp Biochem Physiol A Mol Integr Physiol. 2009;154:353-9 pubmed publisher
    ..IT), prolactin (PRL) and growth hormone (GH) in osmoregulation of a stenohaline marine teleost, tiger puffer (Takifugu rubripes), changes in expression levels of these genes following hypoosmotic challenge, were examined in two ..
  78. Lee K, Yamaguchi A, Rashid H, Kadomura K, Yasumoto S, Matsuyama M. Germ cell degeneration in high-temperature treated pufferfish, Takifugu rubripes. Sex Dev. 2009;3:225-32 pubmed publisher
    ..The Japanese pufferfish, Takifugu rubripes, possesses the most compact genome among vertebrates and has immense potential for studies focusing on ..
  79. Tatsuno R, Shikina M, Shirai Y, Wang J, Soyano K, Nishihara G, et al. Change in the transfer profile of orally administered tetrodotoxin to non-toxic cultured pufferfish Takifugu rubripes depending of its development stage. Toxicon. 2013;65:76-80 pubmed publisher
    ..feed homogenate was administered to 6- and 15-month old non-toxic cultured specimens of the pufferfish Takifugu rubripes at a dose of 40 mouse units (MU) (8.8 ?g)/20 g body weight by oral gavage...
  80. Brudno M, Do C, Cooper G, Kim M, Davydov E, Green E, et al. LAGAN and Multi-LAGAN: efficient tools for large-scale multiple alignment of genomic DNA. Genome Res. 2003;13:721-31 pubmed
    ..Multi-LAGAN is a practical method for generating multiple alignments of long genomic sequences at any evolutionary distance. Our systems are publicly available at http://lagan.stanford.edu...
  81. Amores A, Suzuki T, Yan Y, Pomeroy J, Singer A, Amemiya C, et al. Developmental roles of pufferfish Hox clusters and genome evolution in ray-fin fish. Genome Res. 2004;14:1-10 pubmed
    ..in the Southern pufferfish Spheroides nephelus and interrogated genomic databases for the Japanese pufferfish Takifugu rubripes (fugu)...
  82. Inoue Y, Suenaga Y, Yoshiura Y, Moritomo T, Ototake M, Nakanishi T. Molecular cloning and sequencing of Japanese pufferfish (Takifugu rubripes) NADPH oxidase cDNAs. Dev Comp Immunol. 2004;28:911-25 pubmed publisher
    ..These results suggest that Japanese pufferfish NADPH oxidase components possess functional activities similar to those of human...
  83. Bruce A, Donaldson I, Wood I, Yerbury S, Sadowski M, Chapman M, et al. Genome-wide analysis of repressor element 1 silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF) target genes. Proc Natl Acad Sci U S A. 2004;101:10458-63 pubmed
    ..In addition, this approach provides a unique whole-genome map for a given transcription factor-binding site implicated in establishing specific patterns of neuronal gene expression...
  84. McEwen G, Woolfe A, Goode D, Vavouri T, Callaway H, Elgar G. Ancient duplicated conserved noncoding elements in vertebrates: a genomic and functional analysis. Genome Res. 2006;16:451-65 pubmed
    ..We propose a model whereby gene duplication and the evolution of cis-regulatory elements can be considered in the context of increased morphological diversity and the emergence of the modern vertebrate body plan...
  85. Krietsch T, Fernandes M, Kero J, L sel R, Heyens M, Lam E, et al. Human homologs of the putative G protein-coupled membrane progestin receptors (mPRalpha, beta, and gamma) localize to the endoplasmic reticulum and are not activated by progesterone. Mol Endocrinol. 2006;20:3146-64 pubmed publisher
    ..lines expressing the mPRalpha cloned from the spotted seatrout (Cynoscion nebulosus) and Japanese pufferfish (Takifugu rubripes)...
  86. Jang J, Yotsu Yamashita M. Distribution of tetrodotoxin, saxitoxin, and their analogs among tissues of the puffer fish Fugu pardalis. Toxicon. 2006;48:980-7 pubmed
    ..4-S-CysteinylTTX was detected in liver, spleen, gall, and intestine in 1-6mole% of total of all TTX analogs, supporting our previous hypothesis that 4-S-cysteinylTTX is a metabolite of TTX...
  87. Cardoso J, Pinto V, Vieira F, Clark M, Power D. Evolution of secretin family GPCR members in the metazoa. BMC Evol Biol. 2006;6:108 pubmed
    ..In this study a comprehensive description of family 2 GPCR evolution is given based on in silico and expression analyses of the invertebrate receptor genes...
  88. Yasmin L, Kinoshita S, Asaduzzaman M, Akolkar D, Ikeda D, Ono Y, et al. A 5'-flanking region of embryonic-type myosin heavy chain gene, MYH(M)?????, from torafugu Takifugu rubripes regulates developmental muscle-specific expression. Comp Biochem Physiol Part D Genomics Proteomics. 2011;6:76-81 pubmed publisher
    ..These results clearly demonstrated that the 2.1 kb 5'-flanking region of MYH(M)????? contains essential cis-regulatory sequences for myogenesis that are conserved among torafugu, zebrafish and medaka...
  89. Subramanian S, Kumar S. Gene expression intensity shapes evolutionary rates of the proteins encoded by the vertebrate genome. Genetics. 2004;168:373-81 pubmed
    ..These results provide insights into the differential relationship and effect of the increasing complexity of animal body form on evolutionary rates of proteins...
  90. Tsutsui S, Tasumi S, Suetake H, Kikuchi K, Suzuki Y. Carbohydrate-binding site of a novel mannose-specific lectin from fugu (Takifugu rubripes) skin mucus. Comp Biochem Physiol B Biochem Mol Biol. 2006;143:514-9 pubmed
    Pufflectin-s, identified in the skin mucus of the fugu Takifugu rubripes, is a novel mannose-specific lectin with similar structure to monocotyledonous plant lectins...
  91. Kurita Y, Nakada T, Kato A, Doi H, Mistry A, Chang M, et al. Identification of intestinal bicarbonate transporters involved in formation of carbonate precipitates to stimulate water absorption in marine teleost fish. Am J Physiol Regul Integr Comp Physiol. 2008;294:R1402-12 pubmed publisher
    ..of HCO3(-) transporters, Slc4 and Slc26, in fresh-water- and SW-acclimated euryhaline pufferfish, mefugu (Takifugu obscurus), and obtained the following candidate clones: NBCe1 (an Na+-HCO3(-) cotransporter) and Slc26a6A and ..
  92. Asaduzzaman M, Akolkar D, Kinoshita S, Watabe S. The expression of multiple myosin heavy chain genes during skeletal muscle development of torafugu Takifugu rubripes embryos and larvae. Gene. 2013;515:144-54 pubmed publisher
    ..However, the expression profiles of MYHs during torafugu Takifugu rubripes development, although extensively studied in adult tissues, have not been sufficiently studied, and also ..