fundulidae

Summary

Summary: Family of small, surface-dwelling fish that inhabit fresh and brackish waters, and coastal marine areas.

Top Publications

  1. Bozinovic G, Oleksiak M. Embryonic gene expression among pollutant resistant and sensitive Fundulus heteroclitus populations. Aquat Toxicol. 2010;98:221-9 pubmed publisher
    ..g., be dependent on gene by environment interactions). ..
  2. Kawaguchi M, Yasumasu S, Shimizu A, Kudo N, Sano K, Iuchi I, et al. Adaptive evolution of fish hatching enzyme: one amino acid substitution results in differential salt dependency of the enzyme. J Exp Biol. 2013;216:1609-15 pubmed publisher
    ..The results suggest a hypothesis that position 36 influences salt-dependent activity of HCE, not with recognition of primary structure around the cleavage site, but with recognition of higher ordered structure of egg envelope protein...
  3. Oleksiak M. Changes in gene expression due to chronic exposure to environmental pollutants. Aquat Toxicol. 2008;90:161-71 pubmed publisher
    ..Overall, the altered gene expression in these populations likely represents both induced and adaptive changes in gene expression. ..
  4. McMillan A, Bagley M, Jackson S, Nacci D. Genetic diversity and structure of an estuarine fish (Fundulus heteroclitus) indigenous to sites associated with a highly contaminated urban harbor. Ecotoxicology. 2006;15:539-48 pubmed
    ..Alternatively, loss in diversity may have been restored with moderate levels of migration and relatively short generation time for this species. ..
  5. Oleksiak M, Roach J, Crawford D. Natural variation in cardiac metabolism and gene expression in Fundulus heteroclitus. Nat Genet. 2005;37:67-72 pubmed
    ..These data suggest that variation in physiological performance is related to the subtle variation in gene expression and that this relationship differs among individuals. ..
  6. Shaw J, Sato J, VanderHeide J, LaCasse T, Stanton C, Lankowski A, et al. The role of SGK and CFTR in acute adaptation to seawater in Fundulus heteroclitus. Cell Physiol Biochem. 2008;22:69-78 pubmed publisher
  7. Oleksiak M, Karchner S, Jenny M, Franks D, Welch D, Hahn M. Transcriptomic assessment of resistance to effects of an aryl hydrocarbon receptor (AHR) agonist in embryos of Atlantic killifish (Fundulus heteroclitus) from a marine Superfund site. BMC Genomics. 2011;12:263 pubmed publisher
    ..The results are consistent with genome-wide disruption of AHR-dependent signaling in NBH fish. ..
  8. Kawaguchi M, Yasumasu S, Shimizu A, Sano K, Iuchi I, Nishida M. Conservation of the egg envelope digestion mechanism of hatching enzyme in euteleostean fishes. FEBS J. 2010;277:4973-87 pubmed publisher
    ..During evolution, the egg envelope digestion by HCE and LCE orthologs was established in the lineage of euteleosts, and the mechanism is suggested to be conserved...
  9. Powell W, Morrison H, Weil E, Karchner S, Sogin M, Stegeman J, et al. Cloning and analysis of the CYP1A promoter from the atlantic killifish (Fundulus heteroclitus). Mar Environ Res. 2004;58:119-24 pubmed
    ..These studies may ultimately shed light on the importance of P4501A activity in xenobiotic toxicity. ..

More Information

Publications83

  1. Whitehead A, Roach J, Zhang S, Galvez F. Genomic mechanisms of evolved physiological plasticity in killifish distributed along an environmental salinity gradient. Proc Natl Acad Sci U S A. 2011;108:6193-8 pubmed publisher
    ..It is not the well-known effectors of osmotic acclimation, but rather the lesser-known immediate-early responses, that appear important in contributing to population differences. ..
  2. Clark B, Matson C, Jung D, Di Giulio R. AHR2 mediates cardiac teratogenesis of polycyclic aromatic hydrocarbons and PCB-126 in Atlantic killifish (Fundulus heteroclitus). Aquat Toxicol. 2010;99:232-40 pubmed publisher
    ..Additionally, this is the first reported use of splice-junction morpholinos in Fundulus. ..
  3. Williams L, Ma X, Boyko A, Bustamante C, Oleksiak M. SNP identification, verification, and utility for population genetics in a non-model genus. BMC Genet. 2010;11:32 pubmed publisher
    ..Markers differentiated species and populations. In total, these approaches were used to quickly determine differences within the Fundulus genome and provide markers for population genetic studies. ..
  4. Mulvey M, Newman M, Vogelbein W, Unger M, Ownby D. Genetic structure and mtDNA diversity of Fundulus heteroclitus populations from polycyclic aromatic hydrocarbon-contaminated sites. Environ Toxicol Chem. 2003;22:671-7 pubmed
    ..Conclusions about gene diversity and the correlation between genetic distance with site differences in PAH concentrations were also consistent with those from tandem genetic analyses based on allozymes. ..
  5. Flight P, Nacci D, Champlin D, Whitehead A, Rand D. The effects of mitochondrial genotype on hypoxic survival and gene expression in a hybrid population of the killifish, Fundulus heteroclitus. Mol Ecol. 2011;20:4503-20 pubmed publisher
  6. Polacik M, Reichard M. Diet overlap among three sympatric African annual killifish species Nothobranchius spp. from Mozambique. J Fish Biol. 2010;77:754-68 pubmed publisher
    ..Mosquito (Diptera) larvae formed only a negligible part of the diet of all the three species. ..
  7. Bard S, Bello S, Hahn M, Stegeman J. Expression of P-glycoprotein in killifish (Fundulus heteroclitus) exposed to environmental xenobiotics. Aquat Toxicol. 2002;59:237-51 pubmed
  8. Shimizu A, Yamashita M. Purification of mummichog (Fundulus heteroclitus) gonadotropins and their subunits, using an immunochemical assay with antisera raised against synthetic peptides. Gen Comp Endocrinol. 2002;125:79-91 pubmed
    ..Nominal MW of each subunit was estimated from SDS-PAGE as 23,000 for GtH-alpha from GtH-I, 22,000 for GtH-alpha from GtH-II, 18,000 for GtH-Ibeta, and 21,000 for GtH-IIbeta. ..
  9. Harbeitner R, Hahn M, Timme Laragy A. Differential sensitivity to pro-oxidant exposure in two populations of killifish (Fundulus heteroclitus). Ecotoxicology. 2013;22:387-401 pubmed publisher
    ..This result suggests that adaptation to tolerate PCBs has altered the sensitivity of NBH fish to oxidative stress during embryonic development, demonstrating a cost of the PCB resistance adaptation. ..
  10. Willett K, Wassenberg D, Lienesch L, Reichert W, Di Giulio R. In vivo and in vitro inhibition of CYP1A-dependent activity in Fundulus heteroclitus by the polynuclear aromatic hydrocarbon fluoranthene. Toxicol Appl Pharmacol. 2001;177:264-71 pubmed
    ..Because FL and perhaps other inhibitory PAHs, co-occur in the environment with CYP1A inducers, CYP1A-dependent bioassays may cause an underestimation of PAH exposures. ..
  11. Polacik M, Reichard M. Asymmetric reproductive isolation between two sympatric annual killifish with extremely short lifespans. PLoS ONE. 2011;6:e22684 pubmed publisher
    ..We highlight and discuss the fact that males of rarer species may often coercively mate with females of a related, more abundant species. ..
  12. Whitehead A, Crawford D. Variation in tissue-specific gene expression among natural populations. Genome Biol. 2005;6:R13 pubmed
    ..We suggest that those subsets of treatment-specific gene expression patterns that are conserved between taxa are most likely to be functionally related to the physiological state in question. ..
  13. Aluru N, Karchner S, Hahn M. Role of DNA methylation of AHR1 and AHR2 promoters in differential sensitivity to PCBs in Atlantic Killifish, Fundulus heteroclitus. Aquat Toxicol. 2011;101:288-94 pubmed publisher
  14. Wills L, Zhu S, Willett K, Di Giulio R. Effect of CYP1A inhibition on the biotransformation of benzo[a]pyrene in two populations of Fundulus heteroclitus with different exposure histories. Aquat Toxicol. 2009;92:195-201 pubmed publisher
    ..This study also indicates that the metabolic adaptation observed in the ER killifish cannot be explained simply by the refractory CYP1 phenotype...
  15. Williams L, Oleksiak M. Evolutionary and functional analyses of cytochrome P4501A promoter polymorphisms in natural populations. Mol Ecol. 2011;20:5236-47 pubmed publisher
    ..These data demonstrate that intraspecific variation, which provides the raw material for natural selection to act on, can occur while maintaining promoter function...
  16. Duvernell D, Lindmeier J, Faust K, Whitehead A. Relative influences of historical and contemporary forces shaping the distribution of genetic variation in the Atlantic killifish, Fundulus heteroclitus. Mol Ecol. 2008;17:1344-60 pubmed publisher
    ..These conditions should be considered when interpreting the evolutionary significance of the distribution of genetic variation among F. heteroclitus populations...
  17. Paschall J, Oleksiak M, VanWye J, Roach J, Whitehead J, Wyckoff G, et al. FunnyBase: a systems level functional annotation of Fundulus ESTs for the analysis of gene expression. BMC Genomics. 2004;5:96 pubmed
    ..This type of "systems-level" analysis is critical to the understanding of patterns of gene expression that underlie biological processes...
  18. Scott C, VanWye J, McDonald M, Crawford D. Technical analysis of cDNA microarrays. PLoS ONE. 2009;4:e4486 pubmed publisher
  19. Gonzalez H, Roling J, Baldwin W, Bain L. Physiological changes and differential gene expression in mummichogs (Fundulus heteroclitus) exposed to arsenic. Aquat Toxicol. 2006;77:43-52 pubmed
    ..5-fold) in the hatchlings whose parents were exposed to arsenic. These genes are important during embryogenesis and their differential expression may be linked to the morphological changes observed in the hatchlings...
  20. Matson C, Clark B, Jenny M, Fleming C, Hahn M, Di Giulio R. Development of the morpholino gene knockdown technique in Fundulus heteroclitus: a tool for studying molecular mechanisms in an established environmental model. Aquat Toxicol. 2008;87:289-95 pubmed publisher
  21. Grove T, McFadden L, Chase P, Moerland T. Effects of temperature, ionic strength and pH on the function of skeletal muscle myosin from a eurythermal fish, Fundulus heteroclitus. J Muscle Res Cell Motil. 2005;26:191-7 pubmed
    ..heteroclitus myosin, and thus other factors must be responsible for the mummichog's swimming performance being comparatively insensitive to environmental variation...
  22. Greytak S, Tarrant A, Nacci D, Hahn M, Callard G. Estrogen responses in killifish (Fundulus heteroclitus) from polluted and unpolluted environments are site- and gene-specific. Aquat Toxicol. 2010;99:291-9 pubmed publisher
    ..We hypothesize that adaptation of killifish to the estrogenic and polluted environment may be occurring through diverse mechanisms that are gene-, tissue type- and life-stage-specific...
  23. Meyer J, Nacci D, Di Giulio R. Cytochrome P4501A (CYP1A) in killifish (Fundulus heteroclitus): heritability of altered expression and relationship to survival in contaminated sediments. Toxicol Sci. 2002;68:69-81 pubmed
    ..Additionally, we investigated the hypothesis that low CYP1A activity (measured as in ovo EROD activity) would correlate to increased survival in Elizabeth River sediment pore water; this hypothesis was not supported by our results...
  24. Scott G, Rogers J, Richards J, Wood C, Schulte P. Intraspecific divergence of ionoregulatory physiology in the euryhaline teleost Fundulus heteroclitus: possible mechanisms of freshwater adaptation. J Exp Biol. 2004;207:3399-410 pubmed
  25. Arzuaga X, Elskus A. Polluted-site killifish (Fundulus heteroclitus) embryos are resistant to organic pollutant-mediated induction of CYP1A activity, reactive oxygen species, and heart deformities. Environ Toxicol Chem. 2010;29:676-82 pubmed publisher
  26. Cohen S. Strong positive selection and habitat-specific amino acid substitution patterns in MHC from an estuarine fish under intense pollution stress. Mol Biol Evol. 2002;19:1870-80 pubmed
  27. Peterson J, Bain L. Differential gene expression in anthracene-exposed mummichogs (Fundulus heteroclitus). Aquat Toxicol. 2004;66:345-55 pubmed
    ..Further insight into the mechanism of toxicity of contaminants will be gained by the ability to identify and use differentially expressed genes as markers of exposure and effects...
  28. Hegelund T, Celander M. Hepatic versus extrahepatic expression of CYP3A30 and CYP3A56 in adult killifish (Fundulus heteroclitus). Aquat Toxicol. 2003;64:277-91 pubmed
    ..Moreover, CYP3A expression also is evident in brain and ovary in killifish, which suggests a role for CYP3A enzymes in biotransformation of xenobiotics and fine-tuning levels of steroid hormones in situ in extrahepatic organs...
  29. Schlotterer C. Towards a molecular characterization of adaptation in local populations. Curr Opin Genet Dev. 2002;12:683-7 pubmed
    ..Recent studies have shown that multilocus scans that compare different populations for several loci can identify genomic regions carrying a mutation that results in a local adaptation...
  30. Sato J, Chapline M, Thibodeau R, Frizzell R, Stanton B. Regulation of human cystic fibrosis transmembrane conductance regulator (CFTR) by serum- and glucocorticoid-inducible kinase (SGK1). Cell Physiol Biochem. 2007;20:91-8 pubmed publisher
    ..SGK1 stimulates CFTR Cl currents in Xenopus oocytes by increasing the number of channels in the plasma membrane. Moreover, the effect of SGK may be mediated by protein-protein interactions involving the PDZ interacting motif...
  31. Scott C, Williams D, Crawford D. The effect of genetic and environmental variation on metabolic gene expression. Mol Ecol. 2009;18:2832-43 pubmed publisher
  32. Whitehead A. The evolutionary radiation of diverse osmotolerant physiologies in killifish (Fundulus sp.). Evolution. 2010;64:2070-85 pubmed publisher
    ..Together, these comparative physiology and phylogenetic data yield insight into the patterns of evolution of ecological specialization...
  33. Proestou D, Flight P, Champlin D, Nacci D. Targeted approach to identify genetic loci associated with evolved dioxin tolerance in Atlantic killifish (Fundulus heteroclitus). BMC Evol Biol. 2014;14:7 pubmed publisher
    ..Multiple tolerant and neighboring sensitive killifish populations were compared with the expectation that genetic loci associated with DLC tolerance would be revealed...
  34. Crawford D, Oleksiak M. The biological importance of measuring individual variation. J Exp Biol. 2007;210:1613-21 pubmed
    ..These data suggest that measures of mRNA expression are meaningful, yet there is a complexity in how gene expression is related to physiological processes...
  35. Calman B, Lin Y, Wallace R. Preparation and use of specific antibodies to the beta-I and beta-II subunits of gonadotropic hormone from Fundulus heteroclitus pituitary. Gen Comp Endocrinol. 2001;123:203-9 pubmed
    ..heteroclitus an inexpensive, easily manipulated model system for studies on the hormonal regulation of fractional spawning common to a large class of commercially important species other than salmonids...
  36. Meyer J, Wassenberg D, Karchner S, Hahn M, Di Giulio R. Expression and inducibility of aryl hydrocarbon receptor pathway genes in wild-caught killifish (Fundulus heteroclitus) with different contaminant-exposure histories. Environ Toxicol Chem. 2003;22:2337-43 pubmed
  37. Podrabsky J, Somero G. Changes in gene expression associated with acclimation to constant temperatures and fluctuating daily temperatures in an annual killifish Austrofundulus limnaeus. J Exp Biol. 2004;207:2237-54 pubmed
    ..This study illustrates the utility of cDNA microarray approaches in both hypothesis-driven and 'discovery-based' investigations of environmental effects on organisms...
  38. Adams S, Lindmeier J, Duvernell D. Microsatellite analysis of the phylogeography, Pleistocene history and secondary contact hypotheses for the killifish, Fundulus heteroclitus. Mol Ecol. 2006;15:1109-23 pubmed
  39. Timme Laragy A, Meyer J, Waterland R, Di Giulio R. Analysis of CpG methylation in the killifish CYP1A promoter. Comp Biochem Physiol C Toxicol Pharmacol. 2005;141:406-11 pubmed
    ..In fish from both the contaminated and the reference site, cytosine methylation was not detectable at any of the 34 CpG sites examined, including 3 that are part of putative xenobiotic response elements...
  40. Scott G, Claiborne J, Edwards S, Schulte P, Wood C. Gene expression after freshwater transfer in gills and opercular epithelia of killifish: insight into divergent mechanisms of ion transport. J Exp Biol. 2005;208:2719-29 pubmed publisher
    ..These results provide insight into the mechanisms of ion transport by killifish gills and opercular epithelia, and demonstrate a potential molecular basis for the differences in physiological function between these two organs...
  41. Fisher M, Oleksiak M. Convergence and divergence in gene expression among natural populations exposed to pollution. BMC Genomics. 2007;8:108 pubmed
    ..These natural populations provide a foundation to discover critical gene pathways that have evolved in a complex natural environment in response to environmental stressors...
  42. Fabra M, Cerd J. Ovarian cysteine proteinases in the teleost Fundulus heteroclitus: molecular cloning and gene expression during vitellogenesis and oocyte maturation. Mol Reprod Dev. 2004;67:282-94 pubmed publisher
    ..The specific temporal pattern of expression of these genes may indicate a potential role of cathepsin L-like and cathepsin F proteases in the YP processing events occurring during fish oocyte maturation and/or early embryogenesis...
  43. Tingaud Sequeira A, Carnevali O, Cerdà J. Cathepsin B differential expression and enzyme processing and activity during Fundulus heteroclitus embryogenesis. Comp Biochem Physiol A Mol Integr Physiol. 2011;158:221-8 pubmed publisher
    ..These results suggest that FhCtsb may be involved in the mechanisms underlying the onset of gastrulation in F. heteroclitus embryos, and may play complementary roles with FhCtsla during yolk metabolism...
  44. Meyer J, Di Giulio R. Patterns of heritability of decreased EROD activity and resistance to PCB 126-induced teratogenesis in laboratory-reared offspring of killifish (Fundulus heteroclitus) from a creosote-contaminated site in the Elizabeth River, VA, USA. Mar Environ Res. 2002;54:621-6 pubmed
    ..Furthermore, the pattern of greater resistance to acute toxicity and P4501A-inducing activity in the first generation and less in subsequent generations is also observed upon exposure to PCB-126...
  45. Whitehead A, Galvez F, Zhang S, Williams L, Oleksiak M. Functional genomics of physiological plasticity and local adaptation in killifish. J Hered. 2011;102:499-511 pubmed publisher
    ..Similarly, exploiting the natural phenotypic variation associated with other established and emerging model organisms is likely to greatly accelerate the pace of discovery of the genomic basis of phenotypic variation...
  46. Wills L, Matson C, Landon C, Di Giulio R. Characterization of the recalcitrant CYP1 phenotype found in Atlantic killifish (Fundulus heteroclitus) inhabiting a Superfund site on the Elizabeth River, VA. Aquat Toxicol. 2010;99:33-41 pubmed publisher
    ..The ER adaptation involves the suppression of normal AHR-inducible gene expression for all three CYP1 genes, and therefore is likely an alteration in AHR signaling or control...
  47. Nacci D, Champlin D, Coiro L, McKinney R, Jayaraman S. Predicting the occurrence of genetic adaptation to dioxinlike compounds in populations of the estuarine fish Fundulus heteroclitus. Environ Toxicol Chem. 2002;21:1525-32 pubmed
    ..This study presents an approach and describes a model system that may improve understanding of the scale of occurrence for these potentially irreversible ecological effects...
  48. Meyer J, Volz D, Freedman J, Di Giulio R. Differential display of hepatic mRNA from killifish (Fundulus heteroclitus) inhabiting a Superfund estuary. Aquat Toxicol. 2005;73:327-41 pubmed
    ..In addition, the results indicate that the effect of contaminated sediment exposure on the expression of a large proportion of the differentially expressed mRNAs was dependent on the sex of the fish...
  49. Whitehead A. Comparative mitochondrial genomics within and among species of killifish. BMC Evol Biol. 2009;9:11 pubmed publisher
    ..Comparative genomics approaches were used to test multiple evolutionary hypotheses proposed to explain among-population genome variation including directional selection and hybridization...
  50. Oleksiak M, Churchill G, Crawford D. Variation in gene expression within and among natural populations. Nat Genet. 2002;32:261-6 pubmed
    ..These data suggest that substantial natural variation exists in gene expression and that this quantitative variation is important in evolution...
  51. Roling J, Bain L, Gardea Torresdey J, Bader J, Baldwin W. Hexavalent chromium reduces larval growth and alters gene expression in mummichog (Fundulus heteroclitus). Environ Toxicol Chem. 2006;25:2725-33 pubmed
    ..We anticipate using these arrays and the data they provide to monitor effects at polluted sites, to assess the bioavailability of chromium at these sites, and to investigate the efficacy of remediation in chromium-polluted estuaries...
  52. Wassenberg D, Di Giulio R. Teratogenesis in Fundulus heteroclitus embryos exposed to a creosote-contaminated sediment extract and CYP1A inhibitors. Mar Environ Res. 2004;58:163-8 pubmed
    ..Co-exposures with various CYP1A inhibitors significantly decreased CYP1A activity and increased the teratogenicity of the sediment extract. Potential mechanisms for this increased toxicity are discussed herein...
  53. Marshall W, Singer T. Cystic fibrosis transmembrane conductance regulator in teleost fish. Biochim Biophys Acta. 2002;1566:16-27 pubmed
    ..The facility with which teleosts regulate CFTR expression and activation during salinity adaptation make this system an appealing model for the expression and trafficking operation of this labile gene product...
  54. Bozinovic G, Sit T, Hinton D, Oleksiak M. Gene expression throughout a vertebrate's embryogenesis. BMC Genomics. 2011;12:132 pubmed publisher
    ..This study presents statistical analyses of gene expression during all 40 developmental stages in the teleost Fundulus heteroclitus using four biological replicates per stage...
  55. Tingaud Sequeira A, Cerdà J. Phylogenetic relationships and gene expression pattern of three different cathepsin L (Ctsl) isoforms in zebrafish: Ctsla is the putative yolk processing enzyme. Gene. 2007;386:98-106 pubmed
    ..These data therefore suggested that Ctsla is most likely the putative protease involved in yolk processing in fish embryos, while Ctslc seems not to be required during early embryogenesis in zebrafish...
  56. Hahn M, Karchner S, Franks D, Merson R. Aryl hydrocarbon receptor polymorphisms and dioxin resistance in Atlantic killifish (Fundulus heteroclitus). Pharmacogenetics. 2004;14:131-43 pubmed
    ..We discuss the possibility of other functional differences in AHR1 variants or their interaction with other killifish loci (AHR2, AHRR) that may contribute to differences in dioxin sensitivity...
  57. Schmalz W, Hernandez A, Weis P. Hepatic histopathology in two populations of the mummichog, Fundulus heteroclitus. Mar Environ Res. 2002;54:539-42 pubmed
    ..The lack of trematode cysts in PC livers may reflect the lack of an intermediate host in this low biodiversity estuary...
  58. Williams L, Oleksiak M. Signatures of selection in natural populations adapted to chronic pollution. BMC Evol Biol. 2008;8:282 pubmed publisher
    ..The aim of this study was to identify loci that exhibit non-neutral behavior in the F. heteroclitus genome in polluted populations versus clean reference populations...
  59. Healy T, Tymchuk W, Osborne E, Schulte P. Heat shock response of killifish (Fundulus heteroclitus): candidate gene and heterologous microarray approaches. Physiol Genomics. 2010;41:171-84 pubmed publisher
  60. Reichard M, Polacik M, Sedlácek O. Distribution, colour polymorphism and habitat use of the African killifish Nothobranchius furzeri, the vertebrate with the shortest life span. J Fish Biol. 2009;74:198-212 pubmed publisher
    ..Analysis of habitat use of N. furzeri is presented; N. furzeri was associated with pools containing a soft muddy substratum and turbid water...
  61. Roark S, Nacci D, Coiro L, Champlin D, Guttman S. Population genetic structure of a nonmigratory estuarine fish (Fundulus heteroclitus) across a strong gradient of polychlorinated biphenyl contamination. Environ Toxicol Chem. 2005;24:717-25 pubmed
    ..Although allele frequencies clearly reflected a pattern of isolation by distance, the results indicated neither significant loss of genetic diversity nor alteration of allele frequencies for populations of F. heteroclitus in NBH...
  62. Paetzold S, Ross N, Richards R, Jones M, Hellou J, Bard S. Up-regulation of hepatic ABCC2, ABCG2, CYP1A1 and GST in multixenobiotic-resistant killifish (Fundulus heteroclitus) from the Sydney Tar Ponds, Nova Scotia, Canada. Mar Environ Res. 2009;68:37-47 pubmed publisher
    ..The results suggest instead that liver up-regulation of phase I and II enzymes and complementary ABC transporters ABCC2 and ABCG2 may confer contaminant resistance to Tar Pond fish...
  63. Pri Tal B, Blue S, Pau F, Podrabsky J. Hormonal components of altered developmental pathways in the annual killifish, Austrofundulus limnaeus. Gen Comp Endocrinol. 2011;174:166-74 pubmed publisher
    ..These data suggest that steroid hormones may be critical factors involved in determining developmental pathways in embryos of A. limnaeus...
  64. Reitzel A, Karchner S, Franks D, Evans B, Nacci D, Champlin D, et al. Genetic variation at aryl hydrocarbon receptor (AHR) loci in populations of Atlantic killifish (Fundulus heteroclitus) inhabiting polluted and reference habitats. BMC Evol Biol. 2014;14:6 pubmed publisher
  65. Hernández Chávez C, Turgeon J. Asexual and sexual hybrids between Fundulus diaphanus and F. heteroclitus in the Canadian Atlantic region. Mol Ecol. 2007;16:1467-80 pubmed
    ..heteroclitus...
  66. Williams L, Oleksiak M. Ecologically and evolutionarily important SNPs identified in natural populations. Mol Biol Evol. 2011;28:1817-26 pubmed publisher
    ..Extrapolating across the genome, these data suggest that rapid evolutionary change in natural populations can involve hundreds of loci, a few of which will be shared in independent events...
  67. Rees B, Andacht T, Skripnikova E, Crawford D. Population proteomics: quantitative variation within and among populations in cardiac protein expression. Mol Biol Evol. 2011;28:1271-9 pubmed publisher
  68. Whitehead A, Triant D, Champlin D, Nacci D. Comparative transcriptomics implicates mechanisms of evolved pollution tolerance in a killifish population. Mol Ecol. 2010;19:5186-203 pubmed publisher
  69. Fangue N, Hofmeister M, Schulte P. Intraspecific variation in thermal tolerance and heat shock protein gene expression in common killifish, Fundulus heteroclitus. J Exp Biol. 2006;209:2859-72 pubmed publisher
    ..These data highlight the importance of considering the complexity of the heat shock response across multiple isoforms when attempting to make linkages to whole-organism traits such as thermal tolerance...
  70. Kawaguchi M, Yasumasu S, Shimizu A, Hiroi J, Yoshizaki N, Nagata K, et al. Purification and gene cloning of Fundulus heteroclitus hatching enzyme. A hatching enzyme system composed of high choriolytic enzyme and low choriolytic enzyme is conserved between two different teleosts, Fundulus heteroclitus and medaka Oryzias lati. FEBS J. 2005;272:4315-26 pubmed publisher
    ..Such a cooperative digestion was confirmed by electron microscopic observation. The results suggest that a hatching enzyme system composed of HCE and LCE is conserved between two different teleosts Fundulus and medaka...
  71. Mulvey M, Newman M, Vogelbein W, Unger M. Genetic structure of Fundulus heteroclitus from PAH-contaminated and neighboring sites in the Elizabeth and York Rivers. Aquat Toxicol. 2002;61:195-209 pubmed
    ..Mummichog collected at the heavily PAH-contaminated AW locality were genetically distinct from those at neighboring sites...
  72. Ownby D, Newman M, Mulvey M, Vogelbein W, Unger M, Arzayus L. Fish (Fundulus heteroclitus) populations with different exposure histories differ in tolerance of creosote-contaminated sediments. Environ Toxicol Chem. 2002;21:1897-902 pubmed
    ..Differences between fish populations from the two estuaries were larger than differences within the Elizabeth River, and these differences in tolerance were heritable...
  73. Nacci D, Kohan M, Pelletier M, George E. Effects of benzo[a]pyrene exposure on a fish population resistant to the toxic effects of dioxin-like compounds. Aquat Toxicol. 2002;57:203-15 pubmed
    ..These fish populations provide useful models to evaluate the potential costs and benefits of genetic adaptation in wildlife populations subject to anthropogenic stress...
  74. Virkki L, Cooper G, Boron W. Cloning and functional expression of an MIP (AQP0) homolog from killifish (Fundulus heteroclitus) lens. Am J Physiol Regul Integr Comp Physiol. 2001;281:R1994-2003 pubmed
    ..The mercurials HgCl(2) and p-chloromercuribenzenesulfonate inhibit the water permeability of MIPfun by approximately 25%. MIPfun is not permeable to glycerol, urea, or formic acid but is weakly permeable to CO(2)...