oryzias

Summary

Summary: The only genus in the family Oryziinae, order BELONIFORMES. Oryzias are egg-layers; other fish of the same order are livebearers. Oryzias are used extensively in testing carcinogens.

Top Publications

  1. Wang M, Wang Y, Wang J, Lin L, Hong H, Wang D. Proteome profiles in medaka (Oryzias melastigma) liver and brain experimentally exposed to acute inorganic mercury. Aquat Toxicol. 2011;103:129-39 pubmed publisher
    ..Using the proteomic approach, this study examined the protein profiles of the medaka (Oryzias melastigma) liver and brain exposed to an acute mercuric chloride (HgCl(2)) concentration (1000?g/L) for 8h...
  2. Pham C, Park K, Kim B, Kim H, Gu M. Construction and characterization of Japanese medaka (Oryzias latipes) hepatic cDNA library and its implementation to biomarker screening in aquatic toxicology. Aquat Toxicol. 2011;105:569-75 pubmed publisher
    ..The analysis accomplished of the hepatic cDNA library and its information added to genetic and genomic resources could be sufficiently valuable specifically for aquatic toxicity studies. ..
  3. Ochiai T, Suehiro Y, Nishinari K, Kubo T, Takeuchi H. A new data-mining method to search for behavioral properties that induce alignment and their involvement in social learning in medaka fish (Oryzias latipes). PLoS ONE. 2013;8:e71685 pubmed publisher
    ..The data-mining method used in the present study is a powerful method to search for candidates factors associated with inter-individual interactions using a dataset for time-series coordinate data of individuals. ..
  4. Ismail A, Yusof S. Effect of mercury and cadmium on early life stages of Java medaka (Oryzias javanicus): a potential tropical test fish. Mar Pollut Bull. 2011;63:347-9 pubmed publisher
    ..A close relative of the well established Japanese medaka, the Java medaka (Oryzias javanicus), has the potential to be a test organism...
  5. Wan Y, Liu F, Wiseman S, Zhang X, Chang H, Hecker M, et al. Interconversion of hydroxylated and methoxylated polybrominated diphenyl ethers in Japanese medaka. Environ Sci Technol. 2010;44:8729-35 pubmed publisher
    ..of these compounds and their transformation products were investigated in sexually mature Japanese medaka (Oryzias latipes). In addition, transformation of each compound was determined in vitro using liver microsomes of medaka...
  6. Huang Q, Fang C, Wu X, Fan J, Dong S. Perfluorooctane sulfonate impairs the cardiac development of a marine medaka (Oryzias melastigma). Aquat Toxicol. 2011;105:71-7 pubmed publisher
    ..In the present study, we investigated the toxicity of PFOS on the cardiac development using Oryzias melastigma embryos...
  7. Fallahtafti S, Rantanen T, Brown R, Snieckus V, Hodson P. Toxicity of hydroxylated alkyl-phenanthrenes to the early life stages of Japanese medaka (Oryzias latipes). Aquat Toxicol. 2012;106-107:56-64 pubmed publisher
    ..the toxicity of ring and chain hydroxylated 1-methylphenanthrenes to the early life stages of Japanese medaka (Oryzias latipes)...
  8. Hong N, Chen S, Ge R, Song J, Yi M, Hong Y. Interordinal chimera formation between medaka and zebrafish for analyzing stem cell differentiation. Stem Cells Dev. 2012;21:2333-41 pubmed publisher
  9. Jin Y, Chen R, Wang L, Liu J, Yang Y, Zhou C, et al. Effects of metolachlor on transcription of thyroid system-related genes in juvenile and adult Japanese medaka (Oryzias latipes). Gen Comp Endocrinol. 2011;170:487-93 pubmed publisher
    ..The information obtained in the present study suggests that MT has the potential to influence several steps of the hypothalamus-pituitary-thyroid (HPT) axis homeostasis and to disrupt the thyroid system in medaka. ..

More Information

Publications110 found, 100 shown here

  1. Wu Y, Zhou Q. Silver nanoparticles cause oxidative damage and histological changes in medaka (Oryzias latipes) after 14 days of exposure. Environ Toxicol Chem. 2013;32:165-73 pubmed publisher
    ..The oxidative damage caused by AgNPs may be associated with a large number of histological changes in the fish. ..
  2. Conte I, Carrella S, Avellino R, Karali M, Marco Ferreres R, Bovolenta P, et al. miR-204 is required for lens and retinal development via Meis2 targeting. Proc Natl Acad Sci U S A. 2010;107:15491-6 pubmed publisher
    ..Here, we show that a single miRNA, miR-204, regulates multiple aspects of eye development in the medaka fish (Oryzias latipes)...
  3. Kuwashiro S, Terai S, Oishi T, Fujisawa K, Matsumoto T, Nishina H, et al. Telmisartan improves nonalcoholic steatohepatitis in medaka (Oryzias latipes) by reducing macrophage infiltration and fat accumulation. Cell Tissue Res. 2011;344:125-34 pubmed publisher
    ..mechanisms underlying the progression from simple steatosis to nonalcoholic steatohepatitis (NASH) in a medaka (Oryzias latipes) NASH model...
  4. Zhang Z, Wells M, Boswell M, Beldorth I, Kirk L, Wang Y, et al. Identification of robust hypoxia biomarker candidates from fin of medaka (Oryzias latipes). Comp Biochem Physiol C Toxicol Pharmacol. 2012;155:11-7 pubmed publisher
    ..In this project, we used a Japanese ricefish (medaka, Oryzias latipes) 8K oligonucleotide array as a platform to identify potential hypoxic biomarkers in different organs (fin,..
  5. Kagawa N. Comparison of aggressive behaviors between two wild populations of Japanese medaka, Oryzias latipes and O. sakaizumii. Zoolog Sci. 2014;31:116-21 pubmed publisher
    ..This study compared aggressiveness between two distinct wild populations of Japanese medaka: a Northern population, Oryzias sakaizumii, and a Southern population, O. latipes...
  6. Chakraborty T, Shibata Y, Zhou L, Katsu Y, Iguchi T, Nagahama Y. Differential expression of three estrogen receptor subtype mRNAs in gonads and liver from embryos to adults of the medaka, Oryzias latipes. Mol Cell Endocrinol. 2011;333:47-54 pubmed publisher
    ..These findings suggest each action of E2 to be mediated by different types of ERs...
  7. Okuyama T, Suehiro Y, Imada H, Shimada A, Naruse K, Takeda H, et al. Induction of c-fos transcription in the medaka brain (Oryzias latipes) in response to mating stimuli. Biochem Biophys Res Commun. 2011;404:453-7 pubmed publisher
    ..Our results indicated that c-fos expression was induced in response to behavioral stimuli in the medaka brain and that medaka c-fos could be a useful marker of neural activity...
  8. Ogiwara K, Ikeda T, Takahashi T. A new in vitro ovulation model for medaka based on whole ovary culture. Zoolog Sci. 2010;27:762-7 pubmed publisher
    ..The present study indicates that our new in vitro ovulation model is useful for investigating the role of germinal epithelial cells in the ovulate process of the medaka fish. ..
  9. Liedtke D, Erhard I, Schartl M. snail gene expression in the medaka, Oryzias latipes. Gene Expr Patterns. 2011;11:181-9 pubmed publisher
    ..and to compare the expression patterns of snai genes in a second main fish model we used the medaka fish (Oryzias latipes), a complementary teleost model to zebrafish...
  10. Willems B, Büttner A, Huysseune A, Renn J, Witten P, Winkler C. Conditional ablation of osteoblasts in medaka. Dev Biol. 2012;364:128-37 pubmed publisher
    ..Taken together, the osx:CFP-NTR medaka line represents a valuable tool to study osteoblast function and regeneration at different stages of development in whole vertebrate specimens in vivo. ..
  11. Pennington K, Kapuscinski A, Morton M, Cooper A, Miller L. Full life-cycle assessment of gene flow consistent with fitness differences in transgenic and wild-type Japanese medaka fish (Oryzias latipes). Environ Biosafety Res. 2010;9:41-57 pubmed publisher
    ..experiments in which we released two lines of growth-enhanced transgenic fish (T67 and T400), Japanese medaka (Oryzias latipes), into populations of wild-type (W) medaka in structured mesocosms...
  12. Shen W, Horng J, Lin L. Functional plasticity of mitochondrion-rich cells in the skin of euryhaline medaka larvae (Oryzias latipes) subjected to salinity changes. Am J Physiol Regul Integr Comp Physiol. 2011;300:R858-68 pubmed publisher
    ..and Cl(-) transport by the yolk-sac skin and individual mitochondrion-rich cells (MRCs) in intact medaka larvae (Oryzias latipes)...
  13. Chakraborty T, Katsu Y, Zhou L, Miyagawa S, Nagahama Y, Iguchi T. Estrogen receptors in medaka (Oryzias latipes) and estrogenic environmental contaminants: an in vitro-in vivo correlation. J Steroid Biochem Mol Biol. 2011;123:115-21 pubmed publisher
    ..Medaka (Oryzias latipes) has three estrogen receptor (ER) subtypes, ER?, ER?1 and ER?2...
  14. Masaoka T, Okamoto H, Araki K, Nagoya H, Fujiwara A, Kobayashi T. Identification of the hybrid between Oryzias latipes and Oryzias curvinotus using nuclear genes and mitochondrial gene region. Mar Genomics. 2012;7:37-41 pubmed publisher
    ..Diploid and allotriploid hybrids between Oryzias latipes and Oryzias curvinotus are sterile, which contributes to the sterilization of transgenic O. latipes or O...
  15. Cho Y, Lee S, Kim D, Nam Y. Characterization of stable fluorescent transgenic marine medaka (Oryzias dancena) lines carrying red fluorescent protein gene driven by myosin light chain 2 promoter. Transgenic Res. 2013;22:849-59 pubmed publisher
    ..light chain-2 gene (mlc2f) promoter were established in a truly euryhaline fish species, the marine medaka (Oryzias dancena; Beloniformes)...
  16. Wawrowski A, Gerlach F, Hankeln T, Burmester T. Changes of globin expression in the Japanese medaka (Oryzias latipes) in response to acute and chronic hypoxia. J Comp Physiol B. 2011;181:199-208 pubmed publisher
    ..The Japanese ricefish medaka (Oryzias latipes) is an important model organism for biomedical research that shows remarkable tolerance towards hypoxia...
  17. Yi M, Hong N, Hong Y. Derivation and characterization of haploid embryonic stem cell cultures in medaka fish. Nat Protoc. 2010;5:1418-30 pubmed publisher
    ..It takes about 15 weeks to generate stable cultures, 5-8 weeks to obtain pure haploid cells and 5-6 weeks to characterize ES cells in vitro and in vivo. ..
  18. Ding L, Kuhne W, Hinton D, Song J, Dynan W. Quantifiable biomarkers of normal aging in the Japanese medaka fish (Oryzias latipes). PLoS ONE. 2010;5:e13287 pubmed publisher
    ..Here we characterize biomarkers associated with normal aging in the Japanese medaka (Oryzias latipes), a species that has been widely used in toxicology studies and has potential utility as a model organism ..
  19. Isoe Y, Okuyama T, Taniguchi Y, Kubo T, Takeuchi H. p53 Mutation suppresses adult neurogenesis in medaka fish (Oryzias latipes). Biochem Biophys Res Commun. 2012;423:627-31 pubmed publisher
    ..Here, we report that the p53 null mutation in medaka fish (Oryzias latipes) suppressed neurogenesis in the telencephalon, independent of cell death...
  20. Kawaguchi M, Yasumasu S, Shimizu A, Kudo N, Sano K, Iuchi I, et al. Adaptive evolution of fish hatching enzyme: one amino acid substitution results in differential salt dependency of the enzyme. J Exp Biol. 2013;216:1609-15 pubmed publisher
    Embryos of medaka Oryzias latipes hatch in freshwater, while those of killifish Fundulus heteroclitus hatch in brackish water...
  21. Li M, Yuan Y, Hong Y. Identification of the RNAs for transcription factor Mitf as a component of the Balbiani body. J Genet Genomics. 2013;40:75-81 pubmed publisher
    ..Here we report in the fish medaka (Oryzias latipes) that RNAs encoding microphthalmia-associated transcription factor (Mitf) are prominent components of the ..
  22. Okubo K, Takeuchi A, Chaube R, Paul Prasanth B, Kanda S, Oka Y, et al. Sex differences in aromatase gene expression in the medaka brain. J Neuroendocrinol. 2011;23:412-23 pubmed publisher
    ..These unique properties of aromatase expression in the brain probably contribute substantially to the less rigid sexual differentiation process, thus ensuring remarkable sexual plasticity in the teleost brain. ..
  23. Wang D, Manali D, Wang T, Bhat N, Hong N, Li Z, et al. Identification of pluripotency genes in the fish medaka. Int J Biol Sci. 2011;7:440-51 pubmed
    ..Therefore, these genes have conserved their pluripotency-specific expression in vitro from mammals to lower vertebrates...
  24. Takeda H, Shimada A. The art of medaka genetics and genomics: what makes them so unique?. Annu Rev Genet. 2010;44:217-41 pubmed publisher
    The medaka fish, Oryzias latipes, is an emerging vertebrate model and now has a high quality draft genome and a number of unique mutants...
  25. Mosi L, Mutoji N, Basile F, Donnell R, Jackson K, Spangenberg T, et al. Mycobacterium ulcerans causes minimal pathogenesis and colonization in medaka (Oryzias latipes): an experimental fish model of disease transmission. Microbes Infect. 2012;14:719-29 pubmed publisher
    ..ulcerans with or without the toxin does not mount acute or chronic infections in Japanese Medaka "Oryzias latipes" even at high doses. Moreover, M...
  26. Pezzementi L, Nachon F, Chatonnet A. Evolution of acetylcholinesterase and butyrylcholinesterase in the vertebrates: an atypical butyrylcholinesterase from the Medaka Oryzias latipes. PLoS ONE. 2011;6:e17396 pubmed publisher
    ..we expressed in vitro, characterized, and modeled a recombinant cholinesterase (ChE) from a teleost, the medaka Oryzias latipes. In addition to AChE, O...
  27. Zhou L, Charkraborty T, Yu X, Wu L, Liu G, Mohapatra S, et al. R-spondins are involved in the ovarian differentiation in a teleost, medaka (Oryzias latipes). BMC Dev Biol. 2012;12:36 pubmed publisher
    ..In the present study, full-length cDNAs of Rspo1, 2 and 3 were cloned from the gonads of medaka (Oryzias latipes). The deduced amino acid sequences of mRspo1-3 were shown to have a similar structural organization...
  28. Renn J, Büttner A, To T, Chan S, Winkler C. A col10a1:nlGFP transgenic line displays putative osteoblast precursors at the medaka notochordal sheath prior to mineralization. Dev Biol. 2013;381:134-43 pubmed publisher
    ..This opens the possibility that sclerotome derived cells in teleosts are implicated in the establishment of the mineralized vertebral column in a similar manner as previously described for tetrapods...
  29. Li M, Hong N, Gui J, Hong Y. Medaka piwi is essential for primordial germ cell migration. Curr Mol Med. 2012;12:1040-9 pubmed
    ..We addressed this issue by using medaka (Oryzias latipes) as a vertebrate model...
  30. Kawabata Y, Hiraki T, Takeuchi A, Okubo K. Sex differences in the expression of vasotocin/isotocin, gonadotropin-releasing hormone, and tyrosine and tryptophan hydroxylase family genes in the medaka brain. Neuroscience. 2012;218:65-77 pubmed publisher
    ..In the present study, we therefore systematically evaluated sex differences in their expression in the medaka (Oryzias latipes) brain...
  31. Yan Y, Hong N, Chen T, Li M, Wang T, Guan G, et al. p53 gene targeting by homologous recombination in fish ES cells. PLoS ONE. 2013;8:e59400 pubmed publisher
    ..lines and procedures for gene transfer and selection for homologous recombination (HR) events in the fish medaka (Oryzias latipes). Here we report HR-mediated GT in this organism...
  32. Ishikawa T, Kamei Y, Otozai S, Kim J, Sato A, Kuwahara Y, et al. High-resolution melting curve analysis for rapid detection of mutations in a Medaka TILLING library. BMC Mol Biol. 2010;11:70 pubmed publisher
    ..Furthermore, the phenotype of the obtained mutants indicates that medaka is an excellent animal model for investigating genome stability and gene function, especially when combined with TILLING. ..
  33. Sun L, Shao X, Wu Y, Li J, Zhou Q, Lin B, et al. Ontogenetic expression and 17?-estradiol regulation of immune-related genes in early life stages of Japanese medaka (Oryzias latipes). Fish Shellfish Immunol. 2011;30:1131-7 pubmed publisher
    ..In addition, the expression profiles of immune-related genes can be developed for use as biomarkers for future immunotoxicological studies. ..
  34. Wu X, Huang Q, Fang C, Ye T, Qiu L, Dong S. PFOS induced precocious hatching of Oryzias melastigma--from molecular level to individual level. Chemosphere. 2012;87:703-8 pubmed publisher
    ..In this study, a precocious hatching was detected in Oryzias melastigma embryos upon PFOS exposure...
  35. Kashiwada S, Ariza M, Kawaguchi T, Nakagame Y, Jayasinghe B, Gärtner K, et al. Silver nanocolloids disrupt medaka embryogenesis through vital gene expressions. Environ Sci Technol. 2012;46:6278-87 pubmed publisher
  36. Alfano G, Conte I, Caramico T, Avellino R, Arnò B, Pizzo M, et al. Vax2 regulates retinoic acid distribution and cone opsin expression in the vertebrate eye. Development. 2011;138:261-71 pubmed publisher
    ..We confirmed the above described alterations of gene expression in the Oryzias latipes (medaka fish) model system using both Vax2 gain- and loss-of-function assays...
  37. Manabe M, Tatarazako N, Kinoshita M. Uptake, excretion and toxicity of nano-sized latex particles on medaka (Oryzias latipes) embryos and larvae. Aquat Toxicol. 2011;105:576-81 pubmed publisher
    ..study, we investigated the effect of nano-sized, fluorescent, latex particles on the freshwater fish, medaka (Oryzias latipes)...
  38. Fujimori C, Ogiwara K, Hagiwara A, Rajapakse S, Kimura A, Takahashi T. Expression of cyclooxygenase-2 and prostaglandin receptor EP4b mRNA in the ovary of the medaka fish, Oryzias latipes: possible involvement in ovulation. Mol Cell Endocrinol. 2011;332:67-77 pubmed publisher
  39. Ye T, Kang M, Huang Q, Fang C, Chen Y, Shen H, et al. Exposure to DEHP and MEHP from hatching to adulthood causes reproductive dysfunction and endocrine disruption in marine medaka (Oryzias melastigma). Aquat Toxicol. 2014;146:115-26 pubmed publisher
    ..DEHP and its active metabolite mono-(2-ethylhexyl)-phthalate (MEHP) disrupts endocrine function in marine medaka (Oryzias melastigma). Marine medaka larvae were exposed to either DEHP (0.1 and 0.5mg/L) or MEHP (0.1 and 0...
  40. Ishikawa T, Taniguchi Y, Okada T, Takeda S, Mori K. Vertebrate unfolded protein response: mammalian signaling pathways are conserved in Medaka fish. Cell Struct Funct. 2011;36:247-59 pubmed
    ..Here, we examined medaka fish, Oryzias latipes, as a vertebrate model organism, and found that the medaka genome encodes five UPR transducers...
  41. Shimada A, Kawanishi T, Kaneko T, Yoshihara H, Yano T, Inohaya K, et al. Trunk exoskeleton in teleosts is mesodermal in origin. Nat Commun. 2013;4:1639 pubmed publisher
    ..This further implies that the role of the neural crest in skeletogenesis has been predominant in the cephalic region from the early stage of vertebrate evolution...
  42. Kimura T, Naruse K. M-marker 2009, a marker set for mapping medaka mutants using PCR length polymorphisms with an automated microchip gel electrophoresis system. Biotechniques. 2010;49:582-3 pubmed publisher
    ..The marker set permits analysis using an automated microchip electrophoresis system as well as conventional agarose gel electrophoresis...
  43. Kawaguchi M, Yasumasu S, Shimizu A, Sano K, Iuchi I, Nishida M. Conservation of the egg envelope digestion mechanism of hatching enzyme in euteleostean fishes. FEBS J. 2010;277:4973-87 pubmed publisher
    ..During evolution, the egg envelope digestion by HCE and LCE orthologs was established in the lineage of euteleosts, and the mechanism is suggested to be conserved...
  44. Fang C, Wu X, Huang Q, Liao Y, Liu L, Qiu L, et al. PFOS elicits transcriptional responses of the ER, AHR and PPAR pathways in Oryzias melastigma in a stage-specific manner. Aquat Toxicol. 2012;106-107:9-19 pubmed publisher
    ..In conclusion, this study showed that PFOS has an estrogenic activity and endocrine-disruptive properties. Meanwhile, PFOS could elicit transcriptional responses on POPs-related pathways in a stage-specific manner...
  45. To T, Witten P, Renn J, Bhattacharya D, Huysseune A, Winkler C. Rankl-induced osteoclastogenesis leads to loss of mineralization in a medaka osteoporosis model. Development. 2012;139:141-50 pubmed publisher
  46. Pham C, Yi J, Gu M. Biomarker gene response in male Medaka (Oryzias latipes) chronically exposed to silver nanoparticle. Ecotoxicol Environ Saf. 2012;78:239-45 pubmed publisher
    ..The conspicuous induction of choriogenin L and vitellogenin 1 in male fish exposed to Ag-NPs, especially at 7- and 21-day, compared with the exposures of AgNO(3) or control was the first attempt to examine estrogenic effects of Ag-NPs...
  47. Deguchi T, Fujimori K, Kawasaki T, Maruyama K, Yuba S. In vivo visualization of the lymphatic vessels in pFLT4-EGFP transgenic medaka. Genesis. 2012;50:625-34 pubmed publisher
    ..Because a see-through medaka line is transparent until adult, the model is useful for visualizing the lymphatic vessels not only in embryo and fry but also in adult. This model will be a useful tool for analyzing lymphatic development...
  48. Karigo T, Kanda S, Takahashi A, Abe H, Okubo K, Oka Y. Time-of-day-dependent changes in GnRH1 neuronal activities and gonadotropin mRNA expression in a daily spawning fish, medaka. Endocrinology. 2012;153:3394-404 pubmed publisher
    ..GnRH1 neurons and in levels of expression of pituitary gonadotropin mRNA using a daily spawning teleost, medaka (Oryzias latipes)...
  49. Kwok K, Auffan M, Badireddy A, Nelson C, Wiesner M, Chilkoti A, et al. Uptake of silver nanoparticles and toxicity to early life stages of Japanese medaka (Oryzias latipes): effect of coating materials. Aquat Toxicol. 2012;120-121:59-66 pubmed publisher
    ..In conclusion, AgNPs is a source of toxic Ag ions, while itself contribute partially to its toxicity to fish, and which interact with skin surface and were taken up via the gills...
  50. Fujimori C, Ogiwara K, Hagiwara A, Takahashi T. New evidence for the involvement of prostaglandin receptor EP4b in ovulation of the medaka, Oryzias latipes. Mol Cell Endocrinol. 2012;362:76-84 pubmed publisher
    ..These results further substantiate that PGE(2)/Ptger4b signaling is involved in follicle rupture during ovulation in the medaka ovary...
  51. Ye R, Lei E, Lam M, Chan A, Bo J, van de Merwe J, et al. Gender-specific modulation of immune system complement gene expression in marine medaka Oryzias melastigma following dietary exposure of BDE-47. Environ Sci Pollut Res Int. 2011;19:2477-87 pubmed publisher
    ..The potential immunomodulatory effects of BDE-47 on fish complement system were studied using the marine medaka Oryzias melastigma as a model fish. Three-month-old O...
  52. Shimizu A, Shimizu N. Dual promoter expression system with insulator ensures a stringent tissue-specific regulation of two reporter genes in the transgenic fish. Transgenic Res. 2013;22:435-44 pubmed publisher
    ..Thus, our dual promoter expression system with insulator is compatible to the conventional IRES and fused reporter gene systems and will be an alternative method to produce the transgenic fishes...
  53. Hayashi Y, Kobira H, Yamaguchi T, Shiraishi E, Yazawa T, Hirai T, et al. High temperature causes masculinization of genetically female medaka by elevation of cortisol. Mol Reprod Dev. 2010;77:679-86 pubmed publisher
    ..However, little is known about the molecular mechanisms underlying environmental sex determination. The medaka (Oryzias latipes) is a teleost fish with an XX/XY sex determination system...
  54. Kim J, Kim S, Lee S. Differentiation of the toxicities of silver nanoparticles and silver ions to the Japanese medaka (Oryzias latipes) and the cladoceran Daphnia magna. Nanotoxicology. 2011;5:208-14 pubmed publisher
    ..1-1.3) and 1.4 (95% CI = 0.3-2.1) ?g Ag/l, respectively. The 96 h LC(50) values for Oryzias latipes of 60 nm and 300 nm AgNP suspensions were 28 (95% CI = 23-34) and 67 (95% CI = 45-108) ?g Ag/l, ..
  55. Tangtian H, Bo L, Wenhua L, Shin P, Wu R. Estrogenic potential of benzotriazole on marine medaka (Oryzias melastigma). Ecotoxicol Environ Saf. 2012;80:327-32 pubmed publisher
    ..Marine medakas (Oryzias melastigma) were exposed to 0.01, 0.1, and 1mg/L benzotriazole for periods of four and 35 days...
  56. Kobayashi K, Kamei Y, Kinoshita M, Czerny T, Tanaka M. A heat-inducible CRE/LOXP gene induction system in medaka. Genesis. 2013;51:59-67 pubmed publisher
    ..Our results collectively indicate that these lines allow us to perform lineage tracing and mosaic analysis and provide the platform to investigate gene functions at later developmental stage and adult...
  57. Yasuda T, Oda S, Li Z, Kimori Y, Kamei Y, Ishikawa T, et al. Gamma-ray irradiation promotes premature meiosis of spontaneously differentiating testis-ova in the testis of p53-deficient medaka (Oryzias latipes). Cell Death Dis. 2012;3:e395 pubmed publisher
  58. Li M, Guan G, Hong N, Hong Y. Multiple regulatory regions control the transcription of medaka germ gene vasa. Biochimie. 2013;95:850-7 pubmed publisher
    ..These results demonstrate the complexity of transcriptional control of medaka vasa and provide important insights into opposing mechanisms underlying germ gene transcription...
  59. Wang M, Wang Y, Zhang L, Wang J, Hong H, Wang D. Quantitative proteomic analysis reveals the mode-of-action for chronic mercury hepatotoxicity to marine medaka (Oryzias melastigma). Aquat Toxicol. 2013;130-131:123-31 pubmed publisher
    ..We investigated the protein profiles of medaka (Oryzias melastigma) liver chronically exposed to different mercuric chloride (HgCl2) concentrations (1 or 10 ?g/L) for 60 ..
  60. Jin Y, Shu L, Huang F, Cao L, Sun L, Fu Z. Environmental cues influence EDC-mediated endocrine disruption effects in different developmental stages of Japanese medaka (Oryzias latipes). Aquat Toxicol. 2011;101:254-60 pubmed publisher
  61. Li Z, Bhat N, Manali D, Wang D, Hong N, Yi M, et al. Medaka cleavage embryos are capable of generating ES-like cell cultures. Int J Biol Sci. 2011;7:418-25 pubmed
    ..Our data point to the possibility to derive stable cell culture from cleavage embryos in this organism...
  62. Liu T, Liu L, Wei Q, Hong Y. Sperm nuclear transfer and transgenic production in the fish medaka. Int J Biol Sci. 2011;7:469-75 pubmed
    ..Although more demanding for experimentation, sperm-mediated transgenesis should be particularly applicable for aquaculture species with a lengthy generation time and/or a large adult body size...
  63. Masuyama H, Yamada M, Kamei Y, Fujiwara Ishikawa T, Todo T, Nagahama Y, et al. Dmrt1 mutation causes a male-to-female sex reversal after the sex determination by Dmy in the medaka. Chromosome Res. 2012;20:163-76 pubmed publisher
    ..The current study focused on the Dmrt1 function in the teleost medaka, Oryzias latipes, which has an XX-XY sex determination system...
  64. Zhang G, Chen L, Chen J, Ren Z, Wang Z, Chon T. Evidence for the Stepwise Behavioral Response Model (SBRM): the effects of Carbamate Pesticides on medaka (Oryzias latipes) in an online monitoring system. Chemosphere. 2012;87:734-41 pubmed publisher
    ..In order to prove the model, in this study, the behavioral responses (BRs) of medaka (Oryzias latipes) in the exposure of Arprocarb (A), Carbofuran (C) and Methomyl (M) were analyzed in an online monitoring ..
  65. Hwang D, Kim B, Au D, Lee J. Complete mitochondrial genome of the marine medaka Oryzias melastigma (Beloniformes, Adrianichthyidae). Mitochondrial DNA. 2012;23:308-9 pubmed publisher
    ..genome was obtained from the assembled genome data sequenced by next-generation sequencer from the marine medaka Oryzias melastigma...
  66. Kimura T, Shinya M, Naruse K. Genetic analysis of vertebral regionalization and number in medaka (Oryzias latipes) inbred lines. G3 (Bethesda). 2012;2:1317-23 pubmed publisher
    ..Our results emphasize that the developmental process should be considered in genetic analyses for vertebral number...
  67. Ichimura K, Kawashima Y, Nakamura T, Powell R, Hidoh Y, Terai S, et al. Medaka fish, Oryzias latipes, as a model for human obesity-related glomerulopathy. Biochem Biophys Res Commun. 2013;431:712-7 pubmed publisher
    ..Thus, the HFD-medaka has a high potential as an animal model useful for exploring the mechanism underling human ORG...
  68. Paul Prasanth B, Shibata Y, Horiguchi R, Nagahama Y. Exposure to diethylstilbestrol during embryonic and larval stages of medaka fish (Oryzias latipes) leads to sex reversal in genetic males and reduced gonad weight in genetic females. Endocrinology. 2011;152:707-17 pubmed publisher
    ..mechanisms involved in artificially induced ovarian differentiation were analyzed by exposing embryos of medaka (Oryzias latipes) to a potent nonsteroidal estrogen, diethylstilbestrol (DES)...
  69. Cho Y, Lee S, Kim Y, Kim D, Nam Y. Functional ability of cytoskeletal ?-actin regulator to drive constitutive and ubiquitous expression of a fluorescent reporter throughout the life cycle of transgenic marine medaka Oryzias dancena. Transgenic Res. 2011;20:1333-55 pubmed publisher
    Marine medaka Oryzias dancena, a candidate model organism, represents many attractive merits as a material for experimental transgenesis and/or heterologous expression assay particularly in the field of ecotoxicology and developmental ..
  70. Froschauer A, Sprott D, Gerwien F, Henker Y, Rudolph F, Pfennig F, et al. Effective generation of transgenic reporter and gene trap lines of the medaka (Oryzias latipes) using the Ac/Ds transposon system. Transgenic Res. 2012;21:149-62 pubmed publisher
    ..These vectors mimic endogenous expression of the trapped allele in transgenic animals and are capable to interfere with the expression of the wild type allele in the homozygous individuals...
  71. Hong N, Li Z, Hong Y. Fish stem cell cultures. Int J Biol Sci. 2011;7:392-402 pubmed
    ..We will also mention semi-cloning as a new development to conventional nuclear transfer...
  72. Magadán Mompó S, Sánchez Espinel C, Gambón Deza F. Immunoglobulin heavy chains in medaka (Oryzias latipes). BMC Evol Biol. 2011;11:165 pubmed publisher
    ..The publication of whole genome sequences and the availability of several cDNA libraries for medaka (Oryzias latipes) permitted us to perform a thorough analysis of immunoglobulin heavy chains present in this teleost.
  73. Cui J, Shen X, Zhao H, Nagahama Y. Genome-wide analysis of Sox genes in Medaka (Oryzias latipes) and their expression pattern in embryonic development. Cytogenet Genome Res. 2011;134:283-94 pubmed publisher
    ..The expression pattern shows that sox genes play a variety of roles in the early embryonic development of medaka...
  74. Trinchet I, Djediat C, Huet H, Dao S, Edery M. Pathological modifications following sub-chronic exposure of medaka fish (Oryzias latipes) to microcystin-LR. Reprod Toxicol. 2011;32:329-40 pubmed publisher
    ..In the males, spermatogenesis appeared to be disrupted. This is the first report showing that a cyanotoxin can affect reproductive function, and so can impact on fish reproduction and thus fish stocks...
  75. Lawrence C, Adatto I, Best J, James A, Maloney K. Generation time of zebrafish (Danio rerio) and medakas (Oryzias latipes) housed in the same aquaculture facility. Lab Anim (NY). 2012;41:158-65 pubmed publisher
    ..These findings show that it is possible to successfully maintain populations of both species within the same research infrastructure without compromising reproductive success or embryo viability...
  76. Ansai S, Ochiai H, Kanie Y, Kamei Y, Gou Y, Kitano T, et al. Targeted disruption of exogenous EGFP gene in medaka using zinc-finger nucleases. Dev Growth Differ. 2012;54:546-56 pubmed publisher
    ..Here, we demonstrated successful gene disruption in somatic and germ cells of medaka (Oryzias latipes) using ZFN to target exogenous EGFP genes...
  77. Zhao Y, Wayne N. Effects of kisspeptin1 on electrical activity of an extrahypothalamic population of gonadotropin-releasing hormone neurons in medaka (Oryzias latipes). PLoS ONE. 2012;7:e37909 pubmed publisher
    ..Our findings provide a new perspective on kisspeptin's broader functions within the central nervous system, through its regulation of an extrahypothalamic population of GnRH neurons involved in multiple neuromodulatory functions...
  78. Morita A, Nakahira K, Hasegawa T, Uchida K, Taniguchi Y, Takeda S, et al. Establishment and characterization of Roberts syndrome and SC phocomelia model medaka (Oryzias latipes). Dev Growth Differ. 2012;54:588-604 pubmed publisher
    ..Downregulation of some gene expression in the R80S mutant is an important clue explaining non-correlation between genotype and phenotype in RBS/SC...
  79. Huang Q, Fang C, Chen Y, Wu X, Ye T, Lin Y, et al. Embryonic exposure to low concentration of bisphenol A affects the development of Oryzias melastigma larvae. Environ Sci Pollut Res Int. 2011;19:2506-14 pubmed publisher
    ..In the present paper, we investigated the cardiac toxicity of BPA using marine medaka (Oryzias melastigma) embryos...
  80. Yasumasu S, Kawaguchi M, Ouchi S, Sano K, Murata K, Sugiyama H, et al. Mechanism of egg envelope digestion by hatching enzymes, HCE and LCE in medaka, Oryzias latipes. J Biochem. 2010;148:439-48 pubmed publisher
    ..Cleaving this site would result in the solubilization of the swollen egg envelope by the disruption of the filamentous structure that is thought to be formed by the non-covalent polymerization of ZP domains...
  81. Mekuchi M, Saito Y, Aoki Y, Masuda T, Iigo M, Yanagisawa T. Molecular cloning, gene structure, molecular evolution and expression analyses of thyrotropin-releasing hormone receptors from medaka (Oryzias latipes). Gen Comp Endocrinol. 2011;170:374-80 pubmed publisher
    Molecular cloning of thyrotropin-releasing hormone receptors (TRHR) was performed in a model teleost fish, medaka (Oryzias latipes)...
  82. Turcotte D, Akhtar P, Bowerman M, Kiparissis Y, Brown R, Hodson P. Measuring the toxicity of alkyl-phenanthrenes to early life stages of medaka (Oryzias latipes) using partition-controlled delivery. Environ Toxicol Chem. 2011;30:487-95 pubmed publisher
    ..the first to describe the chronic toxicity of a series of alkyl-phenanthrenes to the embryos of Japanese medaka (Oryzias latipes) using the partition-controlled delivery (PCD) method of exposure and is the first to establish a ..
  83. Kim M, Kim D, Sohn Y. Characterization of two functional glucocorticoid receptors in the marine medaka Oryzias dancena. Gen Comp Endocrinol. 2011;171:341-9 pubmed publisher
    ..encode the glucocorticoid receptors odGR1 and odGR2 were cloned from a euryhaline teleost, the marine medaka (Oryzias dancena)...
  84. Mongin E, Auer T, Bourrat F, Gruhl F, Dewar K, Blanchette M, et al. Combining computational prediction of cis-regulatory elements with a new enhancer assay to efficiently label neuronal structures in the medaka fish. PLoS ONE. 2011;6:e19747 pubmed publisher
    ..This pipeline represents a significant step towards the dissection of embryonic neuronal development in vertebrates...
  85. Boon Ng G, Gong Z. Maize Ac/Ds transposon system leads to highly efficient germline transmission of transgenes in medaka (Oryzias latipes). Biochimie. 2011;93:1858-64 pubmed publisher
    ..Our data presented here demonstrated the highly efficient transgenesis with the aid of the maize Ac/Ds transposon system...
  86. Schebb N, Flores I, Kurobe T, Franze B, Ranganathan A, Hammock B, et al. Bioconcentration, metabolism and excretion of triclocarban in larval Qurt medaka (Oryzias latipes). Aquat Toxicol. 2011;105:448-54 pubmed publisher
    ..In this study, we investigated bioconcentration, metabolism and elimination of TCC in fish using medaka (Oryzias latipes) as a model. Medaka larvae (7 ± 1 days post hatching) were exposed to 63 nM (20 ?g/L) TCC water for 24h...
  87. Zhao H, Hong N, Lu W, Zeng H, Song J, Hong Y. Fusion gene vectors allowing for simultaneous drug selection, cell labeling, and reporter assay in vitro and in vivo. Anal Chem. 2012;84:987-93 pubmed publisher
    ..Therefore, the pf and pr vectors provide a useful system for simultaneous drug selection, live labeling, and reporter assay in vitro and in vivo...
  88. Barjhoux I, Baudrimont M, Morin B, Landi L, Gonzalez P, Cachot J. Effects of copper and cadmium spiked-sediments on embryonic development of Japanese medaka (Oryzias latipes). Ecotoxicol Environ Saf. 2012;79:272-82 pubmed publisher
    ..Pre-blastula stage medaka (Oryzias latipes) embryos were exposed by static sediment contact to two model heavy metals (cadmium and copper) at ..
  89. Huang Q, Dong S, Fang C, Wu X, Ye T, Lin Y. Deep sequencing-based transcriptome profiling analysis of Oryzias melastigma exposed to PFOS. Aquat Toxicol. 2012;120-121:54-8 pubmed publisher
    b>Oryzias melastigma is a newly emerging marine fish model. However, the application of this model has been restricted because of the lack of genomic information...
  90. Chen J, Zhang X, Wang T, Li Z, Guan G, Hong Y. Efficient detection, quantification and enrichment of subtle allelic alterations. DNA Res. 2012;19:423-33 pubmed publisher
    ..Therefore, PAGE is effective for detection, quantification and enrichment of multiple fine allelic differences and thus offers a versatile tool for screening targeted subtle gene alterations...
  91. Indrieri A, van Rahden V, Tiranti V, Morleo M, Iaconis D, Tammaro R, et al. Mutations in COX7B cause microphthalmia with linear skin lesions, an unconventional mitochondrial disease. Am J Hum Genet. 2012;91:942-9 pubmed publisher
    ..Downregulation of the COX7B ortholog (cox7B) in medaka (Oryzias latipes) resulted in microcephaly and microphthalmia that recapitulated the MLS phenotype and demonstrated an ..
  92. Nakasone K, Nagahama Y, Okubo K. hebp3, a novel member of the heme-binding protein gene family, is expressed in the medaka meninges with higher abundance in females due to a direct stimulating action of ovarian estrogens. Endocrinology. 2013;154:920-30 pubmed publisher
    ..in the teleost brain, we screened for genes differentially expressed between sexes in the brain of medaka (Oryzias latipes)...