Summary: An exotic species of the family CYPRINIDAE, originally from Asia, that has been introduced in North America. Zebrafish is a model organism for drug assay and cancer research.

Top Publications

  1. Jackson H, Ingham P. Control of muscle fibre-type diversity during embryonic development: the zebrafish paradigm. Mech Dev. 2013;130:447-57 pubmed publisher
    ..The zebrafish provides an attractive model for investigating fibre type specification; not only are their rapidly developing ..
  2. Clay M, Halloran M. Rho activation is apically restricted by Arhgap1 in neural crest cells and drives epithelial-to-mesenchymal transition. Development. 2013;140:3198-209 pubmed publisher
    ..Our results provide new insight into mechanisms controlling local Rho activation and how it affects dynamic cell behaviors and actomyosin contraction during key steps of EMT in an intact living organism. ..
  3. Ampatzis K, Song J, Ausborn J, El Manira A. Pattern of innervation and recruitment of different classes of motoneurons in adult zebrafish. J Neurosci. 2013;33:10875-86 pubmed publisher
    ..For this purpose, we have used the in vitro preparation of adult zebrafish. We show that different motoneuron pools are organized in a somatotopic fashion in the motor column related to ..
  4. Duval M, Chung H, Lehmann O, Allison W. Longitudinal fluorescent observation of retinal degeneration and regeneration in zebrafish using fundus lens imaging. Mol Vis. 2013;19:1082-95 pubmed
    ..To address this challenge, we used a custom fundus lens and zebrafish transgenic lines with cell-specific fluorescent reporters to document the state of individual retinal neurons in ..
  5. Tamplin O, White R, Jing L, Kaufman C, Lacadie S, Li P, et al. Small molecule screening in zebrafish: swimming in potential drug therapies. Wiley Interdiscip Rev Dev Biol. 2012;1:459-68 pubmed publisher
    Phenotype-driven chemical genetic screens in zebrafish have become a proven approach for both dissection of developmental mechanisms and discovery of potential therapeutics...
  6. Vajn K, Plunkett J, Tapanes Castillo A, Oudega M. Axonal regeneration after spinal cord injury in zebrafish and mammals: differences, similarities, translation. Neurosci Bull. 2013;29:402-10 pubmed publisher
    ..In the zebrafish (Danio rerio) many but not all axons exhibit successful regeneration after SCI...
  7. Yeh D, Liu Y, Lo Y, Yuh C, Yu G, Lo J, et al. Toll-like receptor 9 and 21 have different ligand recognition profiles and cooperatively mediate activity of CpG-oligodeoxynucleotides in zebrafish. Proc Natl Acad Sci U S A. 2013;110:20711-6 pubmed publisher
    ..In this study, we comparatively investigated zebrafish TLR9 (zebTLR9) and TLR21 (zebTLR21). The two TLRs have similar expression profiles in zebrafish...
  8. Yozzo K, Isales G, Raftery T, Volz D. High-content screening assay for identification of chemicals impacting cardiovascular function in zebrafish embryos. Environ Sci Technol. 2013;47:11302-10 pubmed publisher
    ..Using transgenic zebrafish (fli1:egfp) that stably express eGFP within vascular endothelial cells, we have developed and optimized a 384-..
  9. Suzuki S, Bleckert A, Williams P, Takechi M, Kawamura S, Wong R. Cone photoreceptor types in zebrafish are generated by symmetric terminal divisions of dedicated precursors. Proc Natl Acad Sci U S A. 2013;110:15109-14 pubmed publisher
    ..The modes of cell division generating distinct cone types are unknown. We report here a mechanism whereby zebrafish cone photoreceptors of the same type are produced by symmetric division of dedicated precursors...

More Information


  1. Ben Moshe Z, Alon S, Mracek P, Faigenbloom L, Tovin A, Vatine G, et al. The light-induced transcriptome of the zebrafish pineal gland reveals complex regulation of the circadian clockwork by light. Nucleic Acids Res. 2014;42:3750-67 pubmed publisher
    ..Here, the light-induced transcriptome in the zebrafish central clock organ, the pineal gland, was characterized by messenger RNA (mRNA) sequencing (mRNA-seq) and ..
  2. Pavlidis M, Digka N, Theodoridi A, Campo A, Barsakis K, Skouradakis G, et al. Husbandry of zebrafish, Danio rerio, and the cortisol stress response. Zebrafish. 2013;10:524-31 pubmed publisher
    ..social environment, water quality, handling, and background color) on the cortisol stress response in adult zebrafish, Danio rerio, was investigated to check the usefulness of zebrafish as a model organism in aquaculture research...
  3. Villamizar N, Blanco Vives B, Oliveira C, Dinis M, Di Rosa V, Negrini P, et al. Circadian rhythms of embryonic development and hatching in fish: a comparative study of zebrafish (diurnal), Senegalese sole (nocturnal), and Somalian cavefish (blind). Chronobiol Int. 2013;30:889-900 pubmed publisher
    ..embryonic development and hatching of three teleost species with different daily patterns of behavior: diurnal (zebrafish), nocturnal (Senegalese sole), and blind, not entrained by light (Somalian cavefish)...
  4. Ganser L, Yan Q, James V, Kozol R, Topf M, Harvey R, et al. Distinct phenotypes in zebrafish models of human startle disease. Neurobiol Dis. 2013;60:139-51 pubmed publisher
    ..To validate these candidate disease genes, zebrafish is an ideal choice due to rapid knockdown strategies, accessible embryonic stages, and stereotyped behaviors...
  5. Rodr guez Mar A, Ca estro C, Bremiller R, Catchen J, Yan Y, Postlethwait J. Retinoic acid metabolic genes, meiosis, and gonadal sex differentiation in zebrafish. PLoS ONE. 2013;8:e73951 pubmed publisher
    To help understand the elusive mechanisms of zebrafish sex determination, we studied the genetic machinery regulating production and breakdown of retinoic acid (RA) during the onset of meiosis in gonadogenesis...
  6. Donà E, Barry J, Valentin G, Quirin C, Khmelinskii A, Kunze A, et al. Directional tissue migration through a self-generated chemokine gradient. Nature. 2013;503:285-9 pubmed publisher
    ..Using the zebrafish lateral line primordium as a model, we show that migrating cell collectives can self-generate gradients of ..
  7. Dal Santo G, Conterato G, Barcellos L, Rosemberg D, Piato A. Acute restraint stress induces an imbalance in the oxidative status of the zebrafish brain. Neurosci Lett. 2014;558:103-8 pubmed publisher
    The zebrafish (Danio rerio) has become an emergent model organism for translational approaches focused on the neurobiology of stress due to its genetic, neuroanatomical, and histological similarities with mammalian systems...
  8. Stewart A, Kalueff A. The behavioral effects of acute ??-tetrahydrocannabinol and heroin (diacetylmorphine) exposure in adult zebrafish. Brain Res. 2014;1543:109-19 pubmed publisher
    ..Mounting evidence supports the utility of zebrafish (Danio rerio) for studying various pharmacological manipulations, as an alternative model complementing the ..
  9. Fleming A, Diekmann H, Goldsmith P. Functional characterisation of the maturation of the blood-brain barrier in larval zebrafish. PLoS ONE. 2013;8:e77548 pubmed publisher
    b>Zebrafish are becoming increasingly popular as an organism in which to model human disease and to study the effects of small molecules on complex physiological and pathological processes...
  10. Bernut A, Herrmann J, Kissa K, Dubremetz J, Gaillard J, Lutfalla G, et al. Mycobacterium abscessus cording prevents phagocytosis and promotes abscess formation. Proc Natl Acad Sci U S A. 2014;111:E943-52 pubmed publisher
    ..Exploiting the optical transparency of zebrafish embryos, we observed that the increased virulence of the M...
  11. Lerebours A, Cambier S, Hislop L, Adam Guillermin C, Bourdineaud J. Genotoxic effects of exposure to waterborne uranium, dietary methylmercury and hyperoxia in zebrafish assessed by the quantitative RAPD-PCR method. Mutat Res. 2013;755:55-60 pubmed publisher
    ..impact of low concentration exposures to waterborne uranium (U), dietary methyl mercury (MeHg) and hyperoxia in zebrafish by using the RAPD-PCR quantitative method...
  12. Flasse L, Pirson J, Stern D, Von Berg V, Manfroid I, Peers B, et al. Ascl1b and Neurod1, instead of Neurog3, control pancreatic endocrine cell fate in zebrafish. BMC Biol. 2013;11:78 pubmed publisher
    ..It is repressed by Notch signaling that prevents pancreatic cell differentiation by maintaining precursors in an undifferentiated state...
  13. Turner K, Bracewell T, Hawkins T. Anatomical dissection of zebrafish brain development. Methods Mol Biol. 2014;1082:197-214 pubmed publisher
    Zebrafishbrain.org is an online neuroanatomical atlas of the embryonic zebrafish. The atlas uses high-resolution confocal images and movies of transgenic lines to describe different brain structures...
  14. Puttonen H, Sundvik M, Rozov S, Chen Y, Panula P. Acute ethanol treatment upregulates Th1, Th2, and Hdc in larval zebrafish in stable networks. Front Neural Circuits. 2013;7:102 pubmed publisher
    Earlier studies in zebrafish have revealed that acutely given ethanol has a stimulatory effect on locomotion in fish larvae but the mechanism of this effect has not been revealed...
  15. Jia Q, Zhang Q, Zhang Z, Wang Y, Zhang W, Zhou Y, et al. Transcriptome analysis of the zebrafish model of Diamond-Blackfan anemia from RPS19 deficiency via p53-dependent and -independent pathways. PLoS ONE. 2013;8:e71782 pubmed publisher
    ..In this study, we compared the whole genome RNA-Seq data of zebrafish embryos injected with RPS19 morpholino (RPS19 MO), RPS19 and p53 morpholino simultaneously (RPS19+p53 MO) and ..
  16. Bartoskova M, Dobsíková R, Stancova V, Zivna D, Blahova J, Marsalek P, et al. Evaluation of ibuprofen toxicity for zebrafish (Danio rerio) targeting on selected biomarkers of oxidative stress. Neuro Endocrinol Lett. 2013;34 Suppl 2:102-8 pubmed
    The aim of the study was to investigate the effects of subchronic exposure of zebrafish to ibuprofen, using selected oxidative stress parameters as a target.
  17. White R, Rose K, Zon L. Zebrafish cancer: the state of the art and the path forward. Nat Rev Cancer. 2013;13:624-36 pubmed publisher
    The zebrafish is a recent addition to animal models of human cancer, and studies using this model are rapidly contributing major insights. Zebrafish develop cancer spontaneously, after mutagen exposure and through transgenesis...
  18. Fang Y, Gupta V, Karra R, Holdway J, Kikuchi K, Poss K. Translational profiling of cardiomyocytes identifies an early Jak1/Stat3 injury response required for zebrafish heart regeneration. Proc Natl Acad Sci U S A. 2013;110:13416-21 pubmed publisher
    Certain lower vertebrates like zebrafish activate proliferation of spared cardiomyocytes after cardiac injury to regenerate lost heart muscle...
  19. Corrales J, Thornton C, White M, Willett K. Multigenerational effects of benzo[a]pyrene exposure on survival and developmental deformities in zebrafish larvae. Aquat Toxicol. 2014;148:16-26 pubmed publisher
    ..Benzo[a]pyrene (BaP), a model PAH, is a recognized carcinogen and endocrine disruptor. Here adult zebrafish (F0) were fed 0, 10, 114, or 1,012 ?g BaP/g diet at a feed rate of 1% body weight twice/day for 21 days...
  20. Kim S, Scott S, Bennett M, Carson R, Fessel J, Brown H, et al. Multi-organ abnormalities and mTORC1 activation in zebrafish model of multiple acyl-CoA dehydrogenase deficiency. PLoS Genet. 2013;9:e1003563 pubmed publisher
    ..We report a novel zebrafish mutant dark xavier (dxa(vu463) ) that has an inactivating mutation in the etfa gene...
  21. Reinardy H, Dharamshi J, Jha A, Henry T. Changes in expression profiles of genes associated with DNA repair following induction of DNA damage in larval zebrafish Danio rerio. Mutagenesis. 2013;28:601-8 pubmed publisher
    ..DNA damage was induced in zebrafish larvae by brief exposure (10min) to hydrogen peroxide (H2O2; 100mM), and induction of DNA strand breaks was ..
  22. Markmiller S, Cloonan N, Lardelli R, Doggett K, Keightley M, Boglev Y, et al. Minor class splicing shapes the zebrafish transcriptome during development. Proc Natl Acad Sci U S A. 2014;111:3062-7 pubmed publisher
    ..Here, we describe a unique zebrafish mutant, caliban (clbn), with arrested development of the digestive organs caused by an ethylnitrosourea-induced ..
  23. Faria M, Navas J, Raldua D, Soares A, Barata C. Oxidative stress effects of titanium dioxide nanoparticle aggregates in zebrafish embryos. Sci Total Environ. 2014;470-471:379-89 pubmed publisher
    ..in their coating or crystal structure but of similar primary size (20 nm) plus a micron-sized bulk material to zebrafish embryos without and with SSR...
  24. Austin Tse C, Halbritter J, Zariwala M, Gilberti R, Gee H, Hellman N, et al. Zebrafish Ciliopathy Screen Plus Human Mutational Analysis Identifies C21orf59 and CCDC65 Defects as Causing Primary Ciliary Dyskinesia. Am J Hum Genet. 2013;93:672-86 pubmed publisher
    ..By using zebrafish morpholino knockdown of PCD candidate genes as an in vivo screening platform, we identified c21orf59, ccdc65, ..
  25. Griepenburg J, Ruble B, Dmochowski I. Caged oligonucleotides for bidirectional photomodulation of let-7 miRNA in zebrafish embryos. Bioorg Med Chem. 2013;21:6198-204 pubmed publisher
    ..Here, we describe light-activated (caged) constructs for switching let-7 miRNA 'on' or 'off' with 365 nm light in developing zebrafish embryos.
  26. Cabo R, Zichichi R, Vi a E, Guerrera M, V zquez G, Garc a Su rez O, et al. Calcium-activated potassium channel SK1 is widely expressed in the peripheral nervous system and sensory organs of adult zebrafish. Neurosci Lett. 2013;555:62-7 pubmed publisher
    ..This study was undertaken to analyze the pattern of expression of SK1 in the zebrafish peripheral nervous system and sensory organs using RT-PRC, Westernblot and immunohistochemistry...
  27. Lafontant P, Behzad A, Brown E, Landry P, Hu N, Burns A. Cardiac myocyte diversity and a fibroblast network in the junctional region of the zebrafish heart revealed by transmission and serial block-face scanning electron microscopy. PLoS ONE. 2013;8:e72388 pubmed publisher
    The zebrafish has emerged as an important model of heart development and regeneration...
  28. Lee M, Bonneau A, Takacs C, Bazzini A, DiVito K, Fleming E, et al. Nanog, Pou5f1 and SoxB1 activate zygotic gene expression during the maternal-to-zygotic transition. Nature. 2013;503:360-4 pubmed publisher
    ..In zebrafish, ZGA is required for gastrulation and clearance of maternal messenger RNAs, which is in part regulated by the ..
  29. Gorsuch R, Hyde D. Regulation of Müller glial dependent neuronal regeneration in the damaged adult zebrafish retina. Exp Eye Res. 2014;123:131-40 pubmed publisher
    ..article examines our current knowledge underlying the mechanisms involved in neuronal regeneration in the adult zebrafish retina...
  30. Ablain J, Zon L. Of fish and men: using zebrafish to fight human diseases. Trends Cell Biol. 2013;23:584-6 pubmed publisher
    Long restricted to the field of developmental biology, the use of the zebrafish (Danio rerio) has extended to the study of human pathogenesis...
  31. Bucking C, LeMoine C, Walsh P. Waste nitrogen metabolism and excretion in zebrafish embryos: effects of light, ammonia, and nicotinamide. J Exp Zool A Ecol Genet Physiol. 2013;319:391-403 pubmed publisher
    ..aimed to examine the dynamic scope for changes in rates of urea synthesis and excretion in one such species (zebrafish, Danio rerio) by manipulating the intrinsic developmental rate (by alteration of light:dark cycles), as well as ..
  32. Walcott B, Peterson R. Zebrafish models of cerebrovascular disease. J Cereb Blood Flow Metab. 2014;34:571-7 pubmed publisher
    ..The zebrafish (Danio rerio) is an attractive model for the study of cerebrovascular disease because of its morphological and ..
  33. Ingebretson J, Masino M. Quantification of locomotor activity in larval zebrafish: considerations for the design of high-throughput behavioral studies. Front Neural Circuits. 2013;7:109 pubmed publisher
    High-throughput behavioral studies using larval zebrafish often assess locomotor activity to determine the effects of experimental perturbations...
  34. Mizuno H, Sassa T, Higashijima S, Okamoto H, Miyawaki A. Transgenic zebrafish for ratiometric imaging of cytosolic and mitochondrial Ca2+ response in teleost embryo. Cell Calcium. 2013;54:236-45 pubmed publisher
    ..To investigate Ca2+ signaling at early embryonic stage, we established transgenic zebrafish line expressing a genetically encoded Ca2+ indicator, cameleon YC2...
  35. Zeng C, Sun H, Xie P, Wang J, Zhang G, Chen N, et al. The role of apoptosis in MCLR-induced developmental toxicity in zebrafish embryos. Aquat Toxicol. 2014;149:25-32 pubmed publisher
    ..is able to induce developing toxicity, such as malformation, growth delay and also decreased heart rates in zebrafish embryos...
  36. Uribe P, Asuncion J, Matsui J. Ethanol affects the development of sensory hair cells in larval zebrafish (Danio rerio). PLoS ONE. 2013;8:e83039 pubmed publisher
    ..The goal of this study was to determine if the zebrafish lateral line could be used to study sensory hair cell abnormalities caused by exposure to ethanol during ..
  37. Woods I, Schoppik D, Shi V, Zimmerman S, Coleman H, Greenwood J, et al. Neuropeptidergic signaling partitions arousal behaviors in zebrafish. J Neurosci. 2014;34:3142-60 pubmed publisher
    ..To overcome these limitations, we systematically dissected the neuropeptidergic modulation of arousal in larval zebrafish. We quantified spontaneous locomotor activity and responsiveness to sensory stimuli after genetically induced ..
  38. Helker C, Schuermann A, Karpanen T, Zeuschner D, Belting H, Affolter M, et al. The zebrafish common cardinal veins develop by a novel mechanism: lumen ensheathment. Development. 2013;140:2776-86 pubmed publisher
    ..Here, we focus on the development of the zebrafish common cardinal veins (CCVs), which collect all the blood from the embryo and transport it back to the heart...
  39. Auer T, Duroure K, De Cian A, Concordet J, Del Bene F. Highly efficient CRISPR/Cas9-mediated knock-in in zebrafish by homology-independent DNA repair. Genome Res. 2014;24:142-53 pubmed publisher
    ..and the CRISPR/Cas9 system have greatly expanded the genome editing possibilities in model organisms such as zebrafish. Both systems have recently been used to create knock-out alleles with great efficiency, and TALENs have also ..
  40. Dohn M, Mundell N, Sawyer L, Dunlap J, Jessen J. Planar cell polarity proteins differentially regulate extracellular matrix organization and assembly during zebrafish gastrulation. Dev Biol. 2013;383:39-51 pubmed publisher
    b>Zebrafish gastrulation cell movements occur in the context of dynamic changes in extracellular matrix (ECM) organization and require the concerted action of planar cell polarity (PCP) proteins that regulate cell elongation and ..
  41. Baraban S, Dinday M, Hortopan G. Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment. Nat Commun. 2013;4:2410 pubmed publisher
    ..1 (SCN1A), a voltage-gated sodium channel. Here we characterize zebrafish Nav1.1 (scn1Lab) mutants originally identified in a chemical mutagenesis screen...
  42. Bhandiwad A, Zeddies D, Raible D, Rubel E, Sisneros J. Auditory sensitivity of larval zebrafish (Danio rerio) measured using a behavioral prepulse inhibition assay. J Exp Biol. 2013;216:3504-13 pubmed publisher
    b>Zebrafish (Danio rerio) have become a valuable model for investigating the molecular genetics and development of the inner ear in vertebrates...
  43. Bovo E, Dvornikov A, Mazurek S, de Tombe P, Zima A. Mechanisms of Ca²+ handling in zebrafish ventricular myocytes. Pflugers Arch. 2013;465:1775-84 pubmed publisher
    The zebrafish serves as a promising transgenic animal model that can be used to study cardiac Ca(2+) regulation...
  44. deCarvalho T, Akitake C, Thisse C, Thisse B, Halpern M. Aversive cues fail to activate fos expression in the asymmetric olfactory-habenula pathway of zebrafish. Front Neural Circuits. 2013;7:98 pubmed publisher
    The dorsal habenular nuclei of the zebrafish epithalamus have become a valuable model for studying the development of left-right (L-R) asymmetry and its function in the vertebrate brain...
  45. MARTINEAU P, Mourrain P. Tracking zebrafish larvae in group--status and perspectives. Methods. 2013;62:292-303 pubmed publisher
    Video processing is increasingly becoming a standard procedure in zebrafish behavior investigations as it enables higher research throughput and new or better measures...
  46. Jamison R, Samarage C, Bryson Richardson R, Fouras A. In vivo wall shear measurements within the developing zebrafish heart. PLoS ONE. 2013;8:e75722 pubmed publisher
    ..Utilising the zebrafish model system we have developed a methodology that allows the shear force within the developing embryonic heart ..
  47. Zou P, Chang M, Xue N, Liu X, Li J, Fu J, et al. Melanoma differentiation-associated gene 5 in zebrafish provoking higher interferon-promoter activity through signalling enhancing of its shorter splicing variant. Immunology. 2014;141:192-202 pubmed publisher
    ..In the present study, MDA5 and its spliced shorter forms, named as MDA5a and MDA5b, were identified in zebrafish. MDA5a and MDA5b can be up-regulated in cell lines following the infection of a negative ssRNA virus, the spring ..
  48. Gassman A, Hao L, Bhoite L, Bradford C, Chien C, Beattie C, et al. Small molecule suppressors of Drosophila kinesin deficiency rescue motor axon development in a zebrafish model of spinal muscular atrophy. PLoS ONE. 2013;8:e74325 pubmed publisher
    ..SMA being an axonopathy of motor neurons, the three axonotrophic compounds rescued motor axon development in a zebrafish model of SMA...
  49. Lowe A, Nikolaou N, Hunter P, Thompson I, Meyer M. A systems-based dissection of retinal inputs to the zebrafish tectum reveals different rules for different functional classes during development. J Neurosci. 2013;33:13946-56 pubmed publisher
    We have examined the form, diversity, and organization of three functional classes of retinal inputs to the zebrafish optic tectum during development...
  50. Kedikian X, Faillace M, Bernabeu R. Behavioral and molecular analysis of nicotine-conditioned place preference in zebrafish. PLoS ONE. 2013;8:e69453 pubmed publisher
    ..b>Zebrafish have also been used as a model system to identify factors influencing nicotine-associated reward by using an ..
  51. Pan Y, Freundlich T, Weissman T, Schoppik D, Wang X, Zimmerman S, et al. Zebrabow: multispectral cell labeling for cell tracing and lineage analysis in zebrafish. Development. 2013;140:2835-46 pubmed publisher
    ..Among vertebrates, zebrafish is uniquely suited for in vivo imaging owing to its small size and optical translucency...
  52. Ren G, Li S, Zhong H, Lin S. Zebrafish tyrosine hydroxylase 2 gene encodes tryptophan hydroxylase. J Biol Chem. 2013;288:22451-9 pubmed publisher
    ..To facilitate the understanding of the underling mechanism of PD, several zebrafish PD models have been generated to recapitulate the characteristics of dopaminergic (DA) neuron loss...
  53. Lucas J, Schouman A, Lyphout L, Cousin X, Lefrancois C. Allometric relationship between body mass and aerobic metabolism in zebrafish Danio rerio. J Fish Biol. 2014;84:1171-8 pubmed publisher
    ..through the assessment of active (R(A)) and standard (R(S)) metabolic rate at different life stages in zebrafish Danio rerio (5?day-old larvae, 2?month-old juveniles and 6?month-old adults)...