salamandridae

Summary

Summary: A family of Urodela consisting of 15 living genera and about 42 species and occurring in North America, Europe, Asia, and North Africa.

Top Publications

  1. Sotiropoulos K, Eleftherakos K, Dzukić G, Kalezić M, Legakis A, Polymeni R. Phylogeny and biogeography of the alpine newt Mesotriton alpestris (Salamandridae, Caudata), inferred from mtDNA sequences. Mol Phylogenet Evol. 2007;45:211-26 pubmed
  2. Madhavan M, Haynes T, Frisch N, Call M, Minich C, Tsonis P, et al. The role of Pax-6 in lens regeneration. Proc Natl Acad Sci U S A. 2006;103:14848-53 pubmed
    ..These results conclusively show that Pax-6 is associated with distinct early events during lens regeneration, namely control of cell proliferation and subsequent lens fiber differentiation...
  3. Tsonis P, Call M, Grogg M, Sartor M, Taylor R, Forge A, et al. MicroRNAs and regeneration: Let-7 members as potential regulators of dedifferentiation in lens and inner ear hair cell regeneration of the adult newt. Biochem Biophys Res Commun. 2007;362:940-5 pubmed
    ..This is the first report to correlate expression of miRNAs as novel regulators of vertebrate regeneration, alluding to a novel mechanism whereby transdifferentiation occurs...
  4. Ricote M, Alfaro J, García Tuñón I, Arenas M, Fraile B, Paniagua R, et al. Control of the annual testicular cycle of the marbled-newt by p53, p21, and Rb gene products. Mol Reprod Dev. 2002;63:202-9 pubmed
    ..In the proliferation period and, in a lesser degree, in the spermiogenesis period, the expressions of p53 and p21 decrease and phosph-Rb increases, enhancing cell proliferation. These gene products do not seem to be related to apoptosis...
  5. Yazawa T, Nakayama Y, Fujimoto K, Matsuda Y, Abe K, Kitano T, et al. Abnormal spermatogenesis at low temperatures in the Japanese red-bellied newt, Cynops pyrrhogaster: possible biological significance of the cessation of spermatocytogenesis. Mol Reprod Dev. 2003;66:60-6 pubmed
    ..These results suggest that meiosis at low temperatures cause the production of abnormal spermatozoa. Conservation and the significance of this phenomenon in poikilothermic vertebrates living in the temperate zones are also discussed...
  6. Martínez Solano I, Teixeira J, Buckley D, García París M. Mitochondrial DNA phylogeography of Lissotriton boscai (Caudata, Salamandridae): evidence for old, multiple refugia in an Iberian endemic. Mol Ecol. 2006;15:3375-88 pubmed
    ..We briefly discuss the taxonomic and conservation implications of our results...
  7. Cardall B, Brodie E, Hanifin C. Secretion and regeneration of tetrodotoxin in the rough-skin newt (Taricha granulosa). Toxicon. 2004;44:933-8 pubmed
    ..Over the next 9 months newts significantly regenerated the levels of TTX in their skin. These data, in combination with previously published results, are consistent with the hypothesis that these newts produce their own TTX...
  8. Hanifin C, Brodie E. A predictive model to estimate total skin tetrodotoxin in the newt Taricha granulosa. Toxicon. 2004;43:243-9 pubmed
    ..granulosa are remarkably high...
  9. Hanifin C, Brodie E. Tetrodotoxin levels in eggs of the rough-skin newt, Taricha granulosa, are correlated with female toxicity. J Chem Ecol. 2003;29:1729-39 pubmed
    ..granulosa is not linked to the deposition of other egg resources (e.g.. lipids or other yolk components)...

More Information

Publications62

  1. Makarev E, Call M, Grogg M, Atkinson D, Milash B, Odelberg S, et al. Gene expression signatures in the newt irises during lens regeneration. FEBS Lett. 2007;581:1865-70 pubmed
    ..Such transcriptional activity in the regeneration-incompetent ventral iris was unexpected and calls for a revision of our views about mechanisms of lens regeneration induction...
  2. Abe K, Jin Y, Yamamoto T, Abe S. Human recombinant stem cell factor promotes spermatogonial proliferation, but not meiosis initiation in organ culture of newt testis fragments. Biochem Biophys Res Commun. 2002;294:695-9 pubmed
    ..However, the spermatogonia did not differentiate into primary spermatocytes, but instead died of apoptosis. These results indicate that rhSCF promotes the proliferation of newt spermatogonia, but not the initiation of meiosis...
  3. Yamamoto T, Nakayama Y, Abe S. Mammalian follicle-stimulating hormone and insulin-like growth factor I (IGF-I) up-regulate IGF-I gene expression in organ culture of newt testis. Mol Reprod Dev. 2001;60:56-64 pubmed
    ..These results suggest that the ability of FSH to promote the differentiation of secondary spermatogonia is at least partly mediated by somatic cell-derived IGF-I, and that IGF-I mRNA expression in somatic cells is auto-upregulated...
  4. Nadachowska K, Babik W. Divergence in the face of gene flow: the case of two newts (amphibia: salamandridae). Mol Biol Evol. 2009;26:829-41 pubmed publisher
    ..The distribution of migration times raises the intriguing possibility that even the initial divergence may have occurred in the face of gene flow...
  5. Schmidt B, Van Buskirk J. A comparative analysis of predator-induced plasticity in larval Triturus newts. J Evol Biol. 2005;18:415-25 pubmed
    ..The results showed both similarity and dissimilarity in predator-induced phenotypic plasticity in syntopic larval newts although theory suggests that divergence is unlikely in such ecologically similar species...
  6. Grogg M, Call M, Okamoto M, Vergara M, Del Rio Tsonis K, Tsonis P. BMP inhibition-driven regulation of six-3 underlies induction of newt lens regeneration. Nature. 2005;438:858-62 pubmed
  7. Osikowski A. Asymmetric female preferences for courtship pheromones in two closely-related newt species, the smooth newt (Lissotriton vulgaris) and the Carpathian newt (L. montandoni) (Salamandridae). Zoolog Sci. 2012;29:390-5 pubmed publisher
    ..The results strongly indicate that pheromones play a crucial role in courtship and species recognition in this pair of closely related, hybridizing species...
  8. Litvinchuk S, Rosanov J, Borkin L. Correlations of geographic distribution and temperature of embryonic development with the nuclear DNA content in the Salamandridae (Urodela, Amphibia). Genome. 2007;50:333-42 pubmed
    ..We present an analysis of the relationships between the amount of nuclear DNA and water temperature at the breeding sites...
  9. Casco Robles M, Yamada S, Miura T, Nakamura K, Haynes T, Maki N, et al. Expressing exogenous genes in newts by transgenesis. Nat Protoc. 2011;6:600-8 pubmed publisher
    ..The entire protocol for obtaining transgenic adult newts takes 4-5 months...
  10. Takeuchi H, Kurahashi T. Photolysis of caged cyclic AMP in the ciliary cytoplasm of the newt olfactory receptor cell. J Physiol. 2002;541:825-33 pubmed
    ..This observation suggests that the molecular system regulating desensitization is situated upstream of cAMP production...
  11. Geffeney S, Ruben P, Brodie E. Mechanisms of adaptation in a predator-prey arms race: TTX-resistant sodium channels. Science. 2002;297:1336-9 pubmed
  12. Secondi J, Lepetz V, Théry M. Male attractiveness is influenced by UV wavelengths in a newt species but not in its close relative. PLoS ONE. 2012;7:e30391 pubmed publisher
    ..We discuss the three hypotheses proposed so far for UV signalling in animals (enhanced signal detectability, private communication channel, indicator of individual quality). ..
  13. Jin Y, Uchida I, Eto K, Kitano T, Abe S. Size-selective junctional barrier and Ca(2+)-independent cell adhesion in the testis of Cynops pyrrhogaster: expression and function of occludin. Mol Reprod Dev. 2008;75:202-16 pubmed
  14. Chau R, Kalaitzis J, Neilan B. On the origins and biosynthesis of tetrodotoxin. Aquat Toxicol. 2011;104:61-72 pubmed publisher
    ..The complex biosynthesis of structurally similar toxins, that reveal clues into the biosynthetic pathway of TTX, is also presented...
  15. Johanet A, Secondi J, Lemaire C. Widespread introgression does not leak into allotopy in a broad sympatric zone. Heredity (Edinb). 2011;106:962-72 pubmed publisher
    ..Our study showed that introgression is widespread but remains confined to the sites where the two species reproduce at the same time. This pattern may explain why these species remain genetically distinct over a broad sympatric zone...
  16. Hayashi T, Mizuno N, Owaribe K, Kuroiwa A, Okamoto M. Regulated lens regeneration from isolated pigmented epithelial cells of newt iris in culture in response to FGF2/4. Differentiation. 2002;70:101-8 pubmed
    ..In addition, these findings indicated that unequal competence in the dorsal and ventral iris to FGF2/4 contributes to the difference in lens forming ability between them...
  17. Tsuruda K, Arakawa O, Noguchi T. Toxicity and toxin profiles of the newt, Cynops pyrrhogaster from western Japan. J Nat Toxins. 2001;10:79-89 pubmed
  18. Yazawa T, Fujimoto K, Yamamoto T, Abe S. Caspase activity in newt spermatogonial apoptosis induced by prolactin and cycloheximide. Mol Reprod Dev. 2001;59:209-14 pubmed
    ..As high caspase activity was present in extracts of testes treated with CHX, we suggest that an unidentified caspase induces the morphological changes of apoptosis in newt spermatogonia...
  19. Toyoda F, Yamamoto K, Iwata T, Hasunuma I, Cardinali M, Mosconi G, et al. Peptide pheromones in newts. Peptides. 2004;25:1531-6 pubmed
    ..Significance of pheromones in the form of peptide for those performing reproductive behavior in an aquatic environment was also discussed...
  20. Iwata T, Conlon J, Nakada T, Toyoda F, Yamamoto K, Kikuyama S. Processing of multiple forms of preprosodefrin in the abdominal gland of the red-bellied newt Cynops pyrrhogaster: regional and individual differences in preprosodefrin gene expression. Peptides. 2004;25:1537-43 pubmed
    ..However, genes encoding sodefrin were found to be expressed in all the specimens sampled...
  21. Denoël M, Ficetola G. Landscape-level thresholds, and newt conservation. Ecol Appl. 2007;17:302-9 pubmed
    ..Thresholds can be a useful concept from which tools may be developed to focus conservation effort for threatened species and their habitats...
  22. Milá B, Carranza S, Guillaume O, Clobert J. Marked genetic structuring and extreme dispersal limitation in the Pyrenean brook newt Calotriton asper (Amphibia: Salamandridae) revealed by genome-wide AFLP but not mtDNA. Mol Ecol. 2010;19:108-20 pubmed publisher
    ..asper. The contrasting lack of variation detected in mtDNA sequence data is intriguing and underscores the importance of multilocus approaches to detect true patterns of gene flow in natural populations of amphibians...
  23. Abe S. Hormonal control of meiosis initiation in the testis from Japanese newt, Cynops pyrrhogaster. Zoolog Sci. 2004;21:691-704 pubmed
    ..Spermatogonia could circumvent the checkpoint by the influence of some factor(s) produced by Sertoli cells upon activation by FSH. Trial to isolate factor(s) responsible for the meiosis-initiation is now underway...
  24. Odelberg S. Cellular plasticity in vertebrate regeneration. Anat Rec B New Anat. 2005;287:25-35 pubmed
    ..These results suggest that the knowledge gained from studying the molecular basis of cellular plasticity in newts and other regeneration-competent model organisms might one day be used to enhance the regenerative potential in mammals...
  25. Geffeney S, Fujimoto E, Brodie E, Ruben P. Evolutionary diversification of TTX-resistant sodium channels in a predator-prey interaction. Nature. 2005;434:759-63 pubmed
    ..These results indicate that the evolution of a physiological trait has occurred through a series of unique functional changes in a gene that is otherwise highly conserved among vertebrates...
  26. Godwin J, Liem K, Brockes J. Tissue factor expression in newt iris coincides with thrombin activation and lens regeneration. Mech Dev. 2010;127:321-8 pubmed publisher
    ..This is the first example of gene expression in a patch of cells that prefigures the location of a regenerative response, and links the immune system with the initiation of a regenerative program...
  27. Henry J, Tsonis P. Molecular and cellular aspects of amphibian lens regeneration. Prog Retin Eye Res. 2010;29:543-55 pubmed publisher
    ..A synthesis describing both systems was long due. In this review we describe the process in both Xenopus and the newt. The known molecular mechanisms are described and compared...
  28. Zukor K, Kent D, Odelberg S. Fluorescent whole-mount method for visualizing three-dimensional relationships in intact and regenerating adult newt spinal cords. Dev Dyn. 2010;239:3048-57 pubmed publisher
    ..These methods should also be widely applicable to the study of other newt tissues and adult tissues from other model systems...
  29. Denoël M, Schabetsberger R, Joly P. Trophic specialisations in alternative heterochronic morphs. Naturwissenschaften. 2004;91:81-4 pubmed
    ..Food diversity may thus favour the evolutionary maintenance of facultative polymorphism in natural populations...
  30. Brodie E, Ridenhour B, Brodie E. The evolutionary response of predators to dangerous prey: hotspots and coldspots in the geographic mosaic of coevolution between garter snakes and newts. Evolution. 2002;56:2067-82 pubmed
    ..Much work remains to fill in the geographic pattern of variation among prey populations and, just as importantly, to explore the variation in the ecology of the interaction that occurs within populations...
  31. Sakakibara S, Hiramatsu H, Takahashi Y, Hisatomi O, Kobayashi Y, Sakami S, et al. Opsin expression in adult, developing, and regenerating newt retinas. Brain Res Mol Brain Res. 2002;103:28-35 pubmed
    ..This suggests that reorganization of the intracellular structure takes place during maturation of the regenerating newt photoreceptors...
  32. Nakayama Y, Yamamoto T, Oba Y, Nagahama Y, Abe S. Molecular cloning, functional characterization, and gene expression of a follicle-stimulating hormone receptor in the testis of newt Cynops pyrrhogaster. Biochem Biophys Res Commun. 2000;275:121-8 pubmed
    ..These results demonstrate that FSH stimulates newt spermatogenesis through the FSH-R. This study, as far as we know, reports for the first time the cloning of an amphibian FSH-R cDNA...
  33. Treer D, Van Bocxlaer I, Matthijs S, Du Four D, Janssenswillen S, Willaert B, et al. Love is blind: indiscriminate female mating responses to male courtship pheromones in newts (Salamandridae). PLoS ONE. 2013;8:e56538 pubmed publisher
    ..In many newts (Salamandridae), the male deposits a spermatophore on the substrate in the water, which the female subsequently takes up with ..
  34. Zhang P, Papenfuss T, Wake M, Qu L, Wake D. Phylogeny and biogeography of the family Salamandridae (Amphibia: Caudata) inferred from complete mitochondrial genomes. Mol Phylogenet Evol. 2008;49:586-97 pubmed publisher
    Phylogenetic relationships of members of the salamander family Salamandridae were examined using complete mitochondrial genomes collected from 42 species representing all 20 salamandrid genera and five outgroup taxa...
  35. Jehle R, Wilson G, Arntzen J, Burke T. Contemporary gene flow and the spatio-temporal genetic structure of subdivided newt populations (Triturus cristatus, T. marmoratus). J Evol Biol. 2005;18:619-28 pubmed
    ..05 and 0.65 and always decreased with N; m was estimated as 0.19-0.63, and was possibly biased upwards. We discuss how genotypic data can reveal fine-scale demographic processes with important microevolutionary implications...
  36. Maki N, Takechi K, Sano S, Tarui H, Sasai Y, Agata K. Rapid accumulation of nucleostemin in nucleolus during newt regeneration. Dev Dyn. 2007;236:941-50 pubmed
    ..These findings suggest that nucleostemin plays a role in the dedifferentiation of newt cells and can provide crucial clues for addressing the molecular events at early steps of cellular dedifferentiation in newts...
  37. Hayashi T, Mizuno N, Takada R, Takada S, Kondoh H. Determinative role of Wnt signals in dorsal iris-derived lens regeneration in newt eye. Mech Dev. 2006;123:793-800 pubmed
    ..Wnt5a did not elicit lens development from the ventral epithelium. These observations indicate that dorsal-specific activation of Wnt2b determines the dorsally limited development of lens from the iris pigmented epithelium...
  38. Kuchta S, Tan A. Isolation by distance and post-glacial range expansion in the rough-skinned newt, Taricha granulosa. Mol Ecol. 2005;14:225-44 pubmed
    ..The relevance of these results for Pacific Northwest biogeography is discussed...
  39. Tsonis P, Vergara M, Spence J, Madhavan M, Kramer E, Call M, et al. A novel role of the hedgehog pathway in lens regeneration. Dev Biol. 2004;267:450-61 pubmed
    ..Down-regulation of ptc-1 was also observed when inhibiting the pathway. These results provide the first evidence of a novel role for the hedgehog pathway in specific regulation of the regenerating lens...
  40. Takeuchi H, Imanaka Y, Hirono J, Kurahashi T. Cross-adaptation between olfactory responses induced by two subgroups of odorant molecules. J Gen Physiol. 2003;122:255-64 pubmed
    ..The data will also provide evidence showing that olfactory response generation and adaptation are regulated by a uniform mechanism for a wide variety of odorants...
  41. Nakagawa T, Jang J, Yotsu Yamashita M. Hydrophilic interaction liquid chromatography-electrospray ionization mass spectrometry of tetrodotoxin and its analogs. Anal Biochem. 2006;352:142-4 pubmed
  42. Denoël M, Joly P, Whiteman H. Evolutionary ecology of facultative paedomorphosis in newts and salamanders. Biol Rev Camb Philos Soc. 2005;80:663-71 pubmed
    ..Further research on facultative paedomorphosis will provide needed insight into these and other important questions facing biologists...
  43. Ortiz Santaliestra M, Marco A, Fernández Benéitez M, Lizana M. Alteration of courtship behavior because of water acidification and minor effect of ammonium nitrate in the Iberian newt (Lissotriton boscai). Environ Toxicol Chem. 2009;28:1500-5 pubmed publisher
    ..This kind of sublethal effect should be considered when estimating potential impacts of water pollution on natural populations...
  44. Hanifin C, Brodie E. Tetrodotoxin levels of the rough-skin newt, Taricha granulosa, increase in long-term captivity. Toxicon. 2002;40:1149-153 pubmed
    ..The stability of TTX toxicity in newts is consistent with other amphibian species where TTX is present and may indicate that exogenous factors play a less important role in TTX toxicity of newts than previously thought...
  45. Del Rio Tsonis K, Tsonis P. Eye regeneration at the molecular age. Dev Dyn. 2003;226:211-24 pubmed
    ..In addition, we stress the place of this field at the molecular age and the importance of the recent technologic advances...
  46. Nakada T, Toyoda F, Iwata T, Yamamoto K, Conlon J, Kato T, et al. Isolation, characterization and bioactivity of a region-specific pheromone, [Val8]sodefrin from the newt Cynops pyrrhogaster. Peptides. 2007;28:774-80 pubmed
    ..It is speculated that the coevolution of a novel pheromone and its complementary receptor in the Nara newts may lead to reproductive isolation and eventual differentiation into a separate species...
  47. Lehman E, Brodie E. No evidence for an endosymbiotic bacterial origin of tetrodotoxin in the newt Taricha granulosa. Toxicon. 2004;44:243-9 pubmed
    ..Amplification of bacterial DNA was seen only in samples taken from newt intestines, a tissue with low concentrations of TTX. These results indicate that symbiotic bacteria are unlikely to be the source of TTX in newts...
  48. Tsonis P, Haynes T, Maki N, Nakamura K, Casco Robles M, Yamada S, et al. Controlling gene loss of function in newts with emphasis on lens regeneration. Nat Protoc. 2011;6:593-9 pubmed publisher
    ..The protocol can take a few days or up to 20 d to complete, depending on the duration of the experiment...
  49. Williams B, Brodie E. A resistant predator and its toxic prey: persistence of newt toxin leads to poisonous (not venomous) snakes. J Chem Ecol. 2004;30:1901-19 pubmed
    ..Three weeks after eating one newt, snakes contained an average of 42 microg of TTX in the liver. This amount could severely incapacitate or kill avian predators, and mammalian predators may be negatively affected as well...
  50. Maki N, Suetsugu Maki R, Tarui H, Agata K, Del Rio Tsonis K, Tsonis P. Expression of stem cell pluripotency factors during regeneration in newts. Dev Dyn. 2009;238:1613-6 pubmed publisher
    ..Furthermore, these factors should enable us to understand the similarities and differences between animal regeneration in the newt and stem cell strategies in mammals. Developmental Dynamics 238:1613-1616, 2009. (c) 2009 Wiley-Liss, Inc...
  51. Onda H, Goldhamer D, Tassava R. An extracellular matrix molecule of newt and axolotl regenerating limb blastemas and embryonic limb buds: immunological relationship of MT1 antigen with tenascin. Development. 1990;108:657-68 pubmed
    ..These data show that tenascin is in the matrix of the urodele blastema and limb bud, and suggest that mAb MT1 identifies urodele tenascin...
  52. Vasquez R, Howell B, Yvon A, Wadsworth P, Cassimeris L. Nanomolar concentrations of nocodazole alter microtubule dynamic instability in vivo and in vitro. Mol Biol Cell. 1997;8:973-85 pubmed
    ..Given that nocodazole increases tubulin GTPase activity, we propose that nocodazole acts by generating TuD subunits that then alter dynamic instability...
  53. Tan A, Wake D. MtDNA phylogeography of the California newt, Taricha torosa (Caudata, Salamandridae). Mol Phylogenet Evol. 1995;4:383-94 pubmed
    ..8% divergence per million years or 0.01 maximum likelihood distance per million years). Phylogenetic implications of mtDNA sequence variation for evolution and biogeography of the T. torosa species complex are discussed...