rana esculenta


Summary: An edible species of the family Ranidae, occurring in Europe and used extensively in biomedical research. Commonly referred to as "edible frog".

Top Publications

  1. Chartrel N, Dujardin C, Leprince J, Desrues L, Tonon M, Cellier E, et al. Isolation, characterization, and distribution of a novel neuropeptide, Rana RFamide (R-RFa), in the brain of the European green frog Rana esculenta. J Comp Neurol. 2002;448:111-27 pubmed
    A novel neuropeptide of the RFamide peptide family was isolated in pure form from a frog (Rana esculenta) brain extract by using reversed-phase high performance liquid chromatography in combination with a radioimmunoassay for mammalian ..
  2. Vorburger C. Fixation of deleterious mutations in clonal lineages: evidence from hybridogenetic frogs. Evolution. 2001;55:2319-32 pubmed
    The hemiclonal waterfrog Rana esculenta (RL genotype), a bisexual hybrid between R. ridibunda (RR) and R. lessonae (LL), eliminates the L genome from its germline and clonally transmits the R genome (hybridogenesis)...
  3. Cassano G, Bellantuono V, Ardizzone C, Lippe C. Atrazine increases the sodium absorption in frog (Rana esculenta) skin. Environ Toxicol Chem. 2006;25:509-13 pubmed
    ..effect on the short-circuit current (I(sc)), a quantitative measure of the ion transport operated by frog (Rana esculenta) skin. Treatment with 5 microM atrazine (1...
  4. Izzo G, Ferrara D, Delrio G, d Istria M, Minucci S. Connexin43 expression in the testis of frog Rana esculenta: sex hormonal regulation. Ann N Y Acad Sci. 2009;1163:425-7 pubmed publisher
    ..It is expressed in several cells types of Rana esculenta testes...
  5. Dityatev A, Chmykhova N, Dityateva G, Babalian A, Kleinle J, Clamann H. Structural and physiological properties of connections between individual reticulospinal axons and lumbar motoneurons of the frog. J Comp Neurol. 2001;430:433-47 pubmed
  6. Pontecorvo G, De Felice B, Carfagna M. A novel repeated sequence DNA originated from a Tc1-like transposon in water green frog Rana esculenta. Gene. 2000;261:205-10 pubmed
    ..e./Tc1 in the genome of the green water frog Rana esculenta. This family consists of tandemly repeated sequences, localized at the centromeric regions of chromosomes as ..
  7. Ali M, Knoop F, Vaudry H, Conlon J. Characterization of novel antimicrobial peptides from the skins of frogs of the Rana esculenta complex. Peptides. 2003;24:955-61 pubmed
    b>Rana esculenta is a hybridogenetic hybrid between Rana ridibunda and Rana lessonae and so is best considered as a complex of interbreeding species rather than a discrete single species...
  8. Nauwelaerts S, Ramsay J, Aerts P. Morphological correlates of aquatic and terrestrial locomotion in a semi-aquatic frog, Rana esculenta: no evidence for a design conflict. J Anat. 2007;210:304-17 pubmed
    ..Size has a great influence on the morphological data and on jumping performance, but not if performance is expressed as velocity. The body shape of an anuran is conservative and scales mostly isometrically...
  9. Som C, Reyer H. Hemiclonal reproduction slows down the speed of Muller's ratchet in the hybridogenetic frog Rana esculenta. J Evol Biol. 2007;20:650-60 pubmed
    ..The hybridogenetic water frog Rana esculenta (E), a hybrid between R. lessonae (L) and R...

More Information


  1. Izzo G, d Istria M, Ferrara D, Serino I, Aniello F, Minucci S. Connexin 43 expression in the testis of the frog Rana esculenta. Zygote. 2006;14:349-57 pubmed
    ..Here we report the partial cloning of a Cx43 transcript of 381 bp from Rana esculenta testis...
  2. Lelli A, Perin P, Martini M, Ciubotaru C, Prigioni I, Valli P, et al. Presynaptic calcium stores modulate afferent release in vestibular hair cells. J Neurosci. 2003;23:6894-903 pubmed
    ..These results strongly suggest that endogenous modulators of the CICR process will affect afferent activity elicited by mechanical stimuli in the physiological frequency range...
  3. Chieffi P, Franco R, Fulgione D, Staibano S. PCNA in the testis of the frog, Rana esculenta: a molecular marker of the mitotic testicular epithelium proliferation. Gen Comp Endocrinol. 2000;119:11-6 pubmed
    ..To examine the different mitotic testicular epithelium proliferation during the annual discontinuous frog (Rana esculenta) spermatogenesis, the temporal and the spatial PCNA expression are described and give a useful endogenous ..
  4. Guglielmotti V, Fiorino L. Nitric oxide synthase activity reveals an asymmetrical organization of the frog habenulae during development: A histochemical and cytoarchitectonic study from tadpoles to the mature Rana esculenta, with notes on the pineal complex. J Comp Neurol. 1999;411:441-54 pubmed
    ..dinucleotide phosphate (NADPH)-diaphorase activity was examined in the habenulae of the developing and adult Rana esculenta. In tadpoles and during metamorphosis, selective neuropil staining was consistently found within a lateral ..
  5. Stabile V, Russo M, Chieffi P. 17beta-estradiol induces Akt-1 through estrogen receptor-beta in the frog (Rana esculenta) male germ cells. Reproduction. 2006;132:477-84 pubmed
    ..Here, we investigate the regulation of the serine/threonine kinase Akt-1 in the frog (Rana esculenta) testis during the annual sexual cycle and, whether 17beta-estradiol (E2) exerts a role in the Akt-1 activity...
  6. Christiansen D, Fog K, Pedersen B, Boomsma J. Reproduction and hybrid load in all-hybrid populations of Rana esculenta water frogs in Denmark. Evolution. 2005;59:1348-61 pubmed
    All-hybrid populations of the water frog, Rana esculenta, are exceptional in consisting of independently and to some extent sexually reproducing interspecific hybrids. In most of its range R...
  7. Matesz C, Kulik A, Bacskai T. Ascending and descending projections of the lateral vestibular nucleus in the frog Rana esculenta. J Comp Neurol. 2002;444:115-28 pubmed
    ..6) In seven places, the LVN projections overlap the receptive areas of proprioceptive fibers, suggesting a convergence of sensory modalities involved in the sense of balance...
  8. Nauwelaerts S, Aerts P. Propulsive impulse as a covarying performance measure in the comparison of the kinematics of swimming and jumping in frogs. J Exp Biol. 2003;206:4341-51 pubmed
    ..the propulsive impulse as a covariate in the comparison of the kinematics of locomotion of a semi-aquatic frog Rana esculenta, across land and through water...
  9. Palmiero C, Ferrara D, De Rienzo G, d Istria M, Minucci S. Ethane 1,2-dimethane sulphonate is a useful tool for studying cell-to-cell interactions in the testis of the frog, Rana esculenta. Gen Comp Endocrinol. 2003;131:38-47 pubmed
    ..destroys Leydig cells (LC), has been used to study cellular interactions in the testis of the frog Rana esculenta. Animals received three consecutive EDS injections and were sacrificed on day 4, 8, and 28 from the first ..
  10. Meccariello R, Chianese R, Cacciola G, Cobellis G, Pierantoni R, Fasano S. Type-1 cannabinoid receptor expression in the frog, Rana esculenta, tissues: a possible involvement in the regulation of testicular activity. Mol Reprod Dev. 2006;73:551-8 pubmed
    ..CB1 mRNA expression profiles were characterized in a wide range of tissues of the anuran amphibian, the frog, Rana esculenta. Besides a strong expression in the CNS, CB1 was also present in testis, kidney, liver, ovary, muscle, heart, ..
  11. Ragghianti M, Bucci S, Marracci S, Casola C, Mancino G, Hotz H, et al. Gametogenesis of intergroup hybrids of hemiclonal frogs. Genet Res. 2007;89:39-45 pubmed
    European water frog hybrids Rana esculenta (R. ridibundaxR...
  12. Martini M, Canella R, Fesce R, Rossi M. Isolation and possible role of fast and slow potassium current components in hair cells dissociated from frog crista ampullaris. Pflugers Arch. 2009;457:1327-42 pubmed publisher
  13. Christiansen D, Reyer H. Effects of geographic distance, sea barriers and habitat on the genetic structure and diversity of all-hybrid water frog populations. Heredity (Edinb). 2011;106:25-36 pubmed publisher
    ..Instead, we found relationships between the genomotype proportions and some of 15 habitat parameters monitored. Body size differences among LLR, LR and LRR further suggest ecological differences...
  14. Talon S, De Luca A, De Bellis M, Desaphy J, Lentini G, Scilimati A, et al. Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na(+) channels enhancing the antimyotonic activity in vivo. Br J Pharmacol. 2001;134:1523-31 pubmed
    ..6. Thus, constraining the chiral centre of tocainide in alpha-proline cycle leads to more potent and stereoselective use-dependent Na(+) channel blockers with improved therapeutic potential...
  15. de Rienzo G, Aniello F, Branno M, Minucci S. Isolation and characterization of a novel member of the relaxin/insulin family from the testis of the frog Rana esculenta. Endocrinology. 2001;142:3231-8 pubmed
    ..In addition, because fRLX expression changes during the annual cycle suggesting its involvement in spermatogenesis, fRLX may be considered a new marker for the study of spermatogenesis in the Rana esculenta.
  16. De Luca A, Natuzzi F, Lentini G, Franchini C, Tortorella V, Conte Camerino D. Stereoselective effects of mexiletine enantiomers on sodium currents and excitability characteristics of adult skeletal muscle fibers. Naunyn Schmiedebergs Arch Pharmacol. 1995;352:653-61 pubmed
  17. Cristino L, Florenzano F, Bentivoglio M, Guglielmotti V. Nitric oxide synthase expression and cell changes in dorsal root ganglia and spinal dorsal horn of developing and adult Rana esculenta indicate a role of nitric oxide in limb metamorphosis. J Comp Neurol. 2004;472:423-36 pubmed
    ..nitric oxide synthase (NOS) in dorsal root ganglia (DRGs) and dorsal horn of the developing and adult frog Rana esculenta. In limb DRGs, NOS positivity was first and selectively detected just before limb bud appearance, increased ..
  18. De Luca A, Natuzzi F, Falcone G, Duranti A, Lentini G, Franchini C, et al. Inhibition of frog skeletal muscle sodium channels by newly synthesized chiral derivatives of mexiletine and tocainide. Naunyn Schmiedebergs Arch Pharmacol. 1997;356:777-87 pubmed
    ..Concomitantly the high potency of Me1 and the open-channel block exerted by To2 can represent important features to get selective blockers for skeletal muscle sodium channels...
  19. Chieffi P, Colucci D Amato G, Staibano S, Franco R, Tramontano D. Estradiol-induced mitogen-activated protein kinase (extracellular signal-regulated kinase 1 and 2) activity in the frog (Rana esculenta) testis. J Endocrinol. 2000;167:77-84 pubmed
    ..We have used a non-mammalian vertebrate model, the frog Rana esculenta, to investigate the regulation of extracellular signal-regulated kinase 1 and 2 (ERK1/2) activity in the ..
  20. Raucci F, Assisi L, D Aniello S, Spinelli P, Botte V, Di Fiore M. Testicular endocrine activity is upregulated by D-aspartic acid in the green frog, Rana esculenta. J Endocrinol. 2004;182:365-76 pubmed
    ..study investigated the involvement of D-aspartic acid (D-Asp) in testicular steroidogenesis of the green frog Rana esculenta and its effect on stimulation of thumb pad morphology and glandular activity, a typical testosterone-dependent ..
  21. Jørgensen F, Kroese A. Ion channel regulation of the dynamical instability of the resting membrane potential in saccular hair cells of the green frog (Rana esculenta). Acta Physiol Scand. 2005;185:271-90 pubmed
  22. Guglielmotti V, Cristino L, Sada E, Bentivoglio M. The epithalamus of the developing and adult frog: calretinin expression and habenular asymmetry in Rana esculenta. Brain Res. 2004;999:9-19 pubmed
    ..with immunohistochemistry in the pineal complex and habenular nuclei (HN) of the developing and adult frog Rana esculenta. The frog pineal complex is a medial structure formed by two interconnected components, the frontal organ and ..
  23. Barni S, Vaccarone R, Bertone V, Fraschini A, Bernini F, Fenoglio C. Mechanisms of changes to the liver pigmentary component during the annual cycle (activity and hibernation) of Rana esculenta L. J Anat. 2002;200:185-94 pubmed
    ..for the changes of melanin content/ distribution we had previously discovered in the liver parenchyma of Rana esculenta during natural hibernation. Melanomacrophagic component response was analysed using morphocytochemical methods...
  24. Cerra M, Gattuso A, Tota B. Cardiac role of frog ANF: negative inotropism and binding sites in Rana esculenta. Regul Pept. 2003;114:91-9 pubmed
    ..myotropic effects and the cardiac distribution of frog atrial natriuretic factor (fANF) have been studied in Rana esculenta. Spontaneously, beating in vitro isolated working heart preparations were treated with increased ..
  25. Meccariello R, Chianese R, Scarpa D, Berruti G, Cobellis G, Pierantoni R, et al. UBPy/MSJ-1 system during male germ cell progression in the frog, Rana esculenta. Gen Comp Endocrinol. 2007;153:275-9 pubmed
    ..conserved function of UBPy/MSJ-1 system, we assayed mUBPy presence in the anuran amphibian, the frog, Rana esculenta, during the annual sexual cycle...
  26. Meccariello R, Franzoni M, Chianese R, Cottone E, Scarpa D, Donna D, et al. Interplay between the endocannabinoid system and GnRH-I in the forebrain of the anuran amphibian Rana esculenta. Endocrinology. 2008;149:2149-58 pubmed publisher
    ..Due to the anatomical features of lower vertebrate brain, in the present paper, we chose the frog Rana esculenta (anuran amphibian) as a suitable model to better investigate such aspects of the reproductive physiology...
  27. Waelti M, Reyer H. Food supply modifies the trade-off between past and future reproduction in a sexual parasite-host system (Rana esculenta, Rana lessonae). Oecologia. 2007;152:415-24 pubmed
    ..investigate this interaction in females of a sexual parasite-host system consisting of the hybridogenetic frog Rana esculenta (E) and one of its parental species Rana lessonae (L)...
  28. Ragghianti M, Guerrini F, Bucci S, Mancino G, Hotz H, Uzzell T, et al. Molecular characterization of a centromeric satellite DNA in the hemiclonal hybrid frog Rana esculenta and its parental species. Chromosome Res. 1995;3:497-506 pubmed
    Hybrid water frogs Rana esculenta reproduce by hybridogenesis: one parental genome (of Rana lessonae) is excluded in the germ line, the other (of Rana ridibunda) is clonally transmitted to haploid gametes...
  29. Bratosin D, Estaquier J, Slomianny C, Tissier J, Quatannens B, Bulai T, et al. On the evolution of erythrocyte programmed cell death: apoptosis of Rana esculenta nucleated red blood cells involves cysteine proteinase activation and mitochondrion permeabilization. Biochimie. 2004;86:183-92 pubmed
    Batracian Rana esculenta erythrocytes cell death induced by either calcium influx, or staurosporine, involves typical apoptotic phenotype...
  30. Birinyi A, Szekely G, Csapó K, Matesz C. Quantitative morphological analysis of the motoneurons innervating muscles involved in tongue movements of the frog Rana esculenta. J Comp Neurol. 2004;470:409-21 pubmed
    ..These findings indicate that characteristic geometry of the dendritic tree may have a preference for one array of fibers over another...
  31. Lazar G, Losonczy A. NADPH-diaphorase-positive neurons and pathways in the brain of the frog Rana esculenta. Anat Embryol (Berl). 1999;199:185-98 pubmed
    We described the NADPH-diaphorase-containing neurons and fibres in the brain of the frog Rana esculenta. In the telencephalon stained cells occurred in the olfactory bulb, all subdivisions of the pallium, the diagonal band, the medial ..
  32. Dityatev A, Birinyi A, Puskar Z, Antal M, Clamann H. A correlative physiological and morphological analysis of monosynaptically connected propriospinal axon-motoneuron pairs in the lumbar spinal cord of frogs. Neuroscience. 2001;106:405-17 pubmed
  33. Belvedere P, Dalla Valle L, Vianello S, Carnevali O, Colombo L. Hormonal steroidogenesis in liver and small intestine of the green frog, Rana esculenta L. Life Sci. 2001;69:2921-30 pubmed
    ..the potential of autonomous hormonal steroidogenesis in liver and small intestine of male and female frogs, Rana esculenta, during the recovery phase...
  34. Cevasco A, Pittaluga A, Do Rego J, Luu The V, Pelletier G, Vaudry H, et al. Immunohistochemical localization of hydroxysteroid sulfotransferase and sulfatase in the brain of Rana esculenta tadpoles. Ann N Y Acad Sci. 2009;1163:365-8 pubmed publisher
    ..HST) and unconjugated steroid enzyme sulfatase (STS), in the brain of the European green frog Rana esculenta during development. HST and STS immunoreactivity were detected from stage VIII-XII...
  35. Martini M, Canella R, Leparulo A, Prigioni I, Fesce R, Rossi M. Ionic currents in hair cells dissociated from frog semicircular canals after preconditioning under microgravity conditions. Am J Physiol Regul Integr Comp Physiol. 2009;296:R1585-97 pubmed publisher
  36. Guerriero G, Roselli C, Paolucci M, Botte V, Ciarcia G. Estrogen receptors and aromatase activity in the hypothalamus of the female frog, Rana esculenta. Fluctuations throughout the reproductive cycle. Brain Res. 2000;880:92-101 pubmed
    ..This study was undertaken to investigate androgen utilization in the hypothalamus of the female frog, Rana esculenta, through a quantification of estrogen receptors and aromatase activity during the reproductive cycle...
  37. Cemerikic D, Nesovic Ostojic J, Popadic D, Knezevic A, Dragovic S, Milovanovic A, et al. Absence of KCNQ1-dependent K+ fluxes in proximal tubular cells of frog kidney. Comp Biochem Physiol A Mol Integr Physiol. 2007;148:635-44 pubmed
    ..RT-PCR showed that KCNQ1 mRNA was not expressed in frog kidney. In conclusion, the KCNQ1-dependent K+ secretory fluxes are absent in proximal tubule of frog kidney...
  38. Bruzzone F, Do Rego J, Luu The V, Pelletier G, Vallarino M, Vaudry H. Immunohistochemical localization and biological activity of 3beta-hydroxysteroid dehydrogenase and 5alpha-reductase in the brain of the frog, Rana esculenta, during development. J Chem Neuroanat. 2010;39:35-50 pubmed publisher
    ..dehydrogenase (3beta-HSD) and 5alpha-reductase (5alpha-R) in the brain of the European green frog, Rana esculenta, during larval development...
  39. Cobellis G, Meccariello R, Fienga G, Pierantoni R, Fasano S. Cytoplasmic and nuclear Fos protein forms regulate resumption of spermatogenesis in the frog, Rana esculenta. Endocrinology. 2002;143:163-70 pubmed
    ..Fos proteins in the regulation of germ cell progression during spermatogenesis has been studied in the frog, Rana esculenta. A peculiarity of this animal model is the finding of Fos in cytoplasmic compartment of primary spermatogonia ..
  40. Christiansen D, Jakob C, Arioli M, Roethlisberger S, Reyer H. Coexistence of diploid and triploid hybrid water frogs: population differences persist in the apparent absence of differential survival. BMC Ecol. 2010;10:14 pubmed publisher
    ..These populations, in which the parental species (P. lessonae with genotype LL and P. ridibundus with genotype RR) are absent, have pond-specific proportions of diploid (LR) and triploid (LLR and LRR) genotypes...
  41. Kozicz T, Arimura A, Maderdrut J, Lázár G. Distribution of urocortin-like immunoreactivity in the central nervous system of the frog Rana esculenta. J Comp Neurol. 2002;453:185-98 pubmed
    ..against rat Ucn to determine the distribution of Ucn-like immunoreactivity in the CNS of the green frog, Rana esculenta. The great majority of Ucn-immunoreactive perikarya was seen in the anterior preoptic area, ventromedial ..
  42. De Luca A, Talon S, De Bellis M, Desaphy J, Lentini G, Corbo F, et al. Optimal requirements for high affinity and use-dependent block of skeletal muscle sodium channel by N-benzyl analogs of tocainide-like compounds. Mol Pharmacol. 2003;64:932-45 pubmed
    ..The new compounds are the most potent tocainide-like sodium channel blockers so far described and have high therapeutic potentials...
  43. Ferrara D, Palmiero C, Branno M, Pierantoni R, Minucci S. Testicular activity of Mos in the frog, Rana esculenta: a new role in spermatogonial proliferation. Biol Reprod. 2004;70:1782-9 pubmed
    ..of c-mos cDNA and the identification of a 60-kDa Mos protein from the testis of the anuran amphibian, Rana esculenta. Both the transcript and the protein are always present at low levels in the testis during the frog annual ..
  44. De Bellis M, De Luca A, Rana F, Cavalluzzi M, Catalano A, Lentini G, et al. Evaluation of the pharmacological activity of the major mexiletine metabolites on skeletal muscle sodium currents. Br J Pharmacol. 2006;149:300-10 pubmed
    ..It is extensively metabolized in humans but little information exists about the pharmacodynamic properties of its metabolites...
  45. Rossi M, Prigioni I, Gioglio L, Rubbini G, Russo G, Martini M, et al. IP3 receptor in the hair cells of frog semicircular canal and its possible functional role. Eur J Neurosci. 2006;23:1775-83 pubmed
    ..Our results indicate the presence and a possibly relevant functional role of IP3-sensitive stores in controlling [Ca2+]i and modulating the vestibular discharge...
  46. Meccariello R, Cobellis G, Scarpa D, Fienga G, Pierantoni R, Fasano S. Detection of msj-1 gene expression in the frog, Rana esculenta testis, brain, and spinal cord. Mol Reprod Dev. 2004;68:149-58 pubmed
    ..role of this protein is evolutionarily conserved, we have investigated if msj-1 gene is expressed in the frog, Rana esculenta. Using reverse transcription-polymerase chain reaction (RT-PCR), a msj-1-like transcript was detected in ..
  47. Polzonetti Magni A, Mosconi G, Carnevali O, Yamamoto K, Hanaoka Y, Kikuyama S. Gonadotropins and reproductive function in the anuran amphibian, Rana esculenta. Biol Reprod. 1998;58:88-93 pubmed
    ..measurement both of peripheral gonadotropins (FSH and LH) and of sex steroids in male and female wild anuran, Rana esculenta, was performed during the annual reproductive cycle; moreover, the role of gonadotropins in the vitellogenic ..
  48. Martini M, Farinelli F, Rossi M, Rispoli G. Ca2+ current of frog vestibular hair cells is modulated by intracellular ATP but not by long-lasting depolarisation. Eur Biophys J. 2007;36:779-86 pubmed
    Some aspects of Ca(2+) channel modulation in hair cells isolated from semicircular canals of the frog (Rana esculenta) have been investigated using the whole-cell technique and intra and extracellular solutions designed to modify the ..
  49. Vedovato N, Rispoli G. A novel technique to study pore-forming peptides in a natural membrane. Eur Biophys J. 2007;36:771-8 pubmed
  50. Neau P, Degeilh F, Lamotte H, Rousseau B, Ripoche P. Photoaffinity labeling of the human red-blood-cell urea-transporter polypeptide components. Possible homology with the Kidd blood group antigen. Eur J Biochem. 1993;218:447-55 pubmed
    ..These results support the hypothesis that the Kidd antigen and the facilitated urea transporter are the same protein. Our estimation of the number of copies in each cell is close to that of the previously published value of 14000...
  51. De Falco M, Laforgia V, Valiante S, Virgilio F, Varano L, De Luca A. Different patterns of expression of five neuropeptides in the adrenal gland and kidney of two species of frog. Histochem J. 2002;34:21-6 pubmed
    ..this study was to demonstrate in the adrenocortical and renal tissues of two species of frog, Rana italica and Rana esculenta, the presence and distribution of five neuropeptides: atrial natriuretic peptide (ANP), Leu-enkephalin (Leu-..
  52. Archetti M. Accumulation of deleterious mutations in hybridogenetic organisms. J Theor Biol. 2005;234:151-2 pubmed
  53. Kecskes S, Matesz C, Birinyi A. Termination of trigeminal primary afferents on glossopharyngeal-vagal motoneurons: possible neural networks underlying the swallowing phase and visceromotor responses of prey-catching behavior. Brain Res Bull. 2013;99:109-16 pubmed publisher
    ..Experiments were performed on Rana esculenta, where the trigeminal and glossopharyngeal (IX)-vagus (X) nerves were labeled simultaneously with different ..