outbred strains animals

Summary

Summary: Animals that are generated from breeding two genetically dissimilar strains of the same species.

Top Publications

  1. Rhodes J, Hosack G, Girard I, Kelley A, Mitchell G, Garland T. Differential sensitivity to acute administration of cocaine, GBR 12909, and fluoxetine in mice selectively bred for hyperactive wheel-running behavior. Psychopharmacology (Berl). 2001;158:120-31 pubmed
    ..To study the neural basis of genetic hyperactivity, we measured acute drug responses of mice (Mus domesticus) from four replicate lines that had been selectively bred (23-24 generations) for increased running-wheel activity...
  2. Flint J, Valdar W, Shifman S, Mott R. Strategies for mapping and cloning quantitative trait genes in rodents. Nat Rev Genet. 2005;6:271-86 pubmed
    ..We review the potential of these strategies to identify genes that underlie QTLs in rodents...
  3. Struve C, Forestier C, Krogfelt K. Application of a novel multi-screening signature-tagged mutagenesis assay for identification of Klebsiella pneumoniae genes essential in colonization and infection. Microbiology. 2003;149:167-76 pubmed
    ..Transposon insertion sites in attenuated mutants were, among others, in genes encoding well-known K. pneumoniae virulence factors such as lipopolysaccharide and capsule, as well as in genes of unknown function...
  4. Struve C, Krogfelt K. Role of capsule in Klebsiella pneumoniae virulence: lack of correlation between in vitro and in vivo studies. FEMS Microbiol Lett. 2003;218:149-54 pubmed
    ..Our study demonstrates the caution needed when extrapolating from results of in vitro studies and emphasizes the necessity of in vivo models in studies of bacterial virulence...
  5. Yalcin B, Willis Owen S, Fullerton J, Meesaq A, Deacon R, Rawlins J, et al. Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mice. Nat Genet. 2004;36:1197-202 pubmed
    ..We then use quantitative complementation to show that Rgs2 is a quantitative trait gene. This combined genetic and functional approach should be applicable to the analysis of any quantitative trait...
  6. Gilbert H, Le Roy P. Methods for the detection of multiple linked QTL applied to a mixture of full and half sib families. Genet Sel Evol. 2007;39:139-58 pubmed
    ..Combining the advantages from both methodologies, we finally propose a complete strategy for rapid and efficient systematic multivariate detections in outbred populations...
  7. Taniwaki N, Andreoli W, Calabrese K, da Silva S, Mortara R. Disruption of myofibrillar proteins in cardiac muscle of Calomys callosus chronically infected with Trypanosoma cruzi and treated with immunosuppressive agent. Parasitol Res. 2005;97:323-31 pubmed
    ..The disruption of the muscle cell architecture was greater as infection progressed, probably as a result of increased myocarditis and physical displacement due to the activity of flagellated parasites...
  8. Kirchain S, Hayward A, Mkandawire J, Qi P, Burds A. Comparison of tetraploid blastocyst microinjection of outbred Crl:CD1(ICR), hybrid B6D2F1/Tac, and inbred C57BL/6NTac embryos for generation of mice derived from embryonic stem cells. Comp Med. 2008;58:145-50 pubmed
    ..7%). For targeted mutant mouse studies, 259 BDF1 blastocysts were surgically transferred yielding 10 pups (3.9%); 569 CD1 blastocysts yielded 44 pups (7.7%)...
  9. Bondurand N, Natarajan D, Barlow A, Thapar N, Pachnis V. Maintenance of mammalian enteric nervous system progenitors by SOX10 and endothelin 3 signalling. Development. 2006;133:2075-86 pubmed
    ..Our findings indicate that SOX10 and endothelin 3 have a crucial role in the maintenance of multilineage enteric nervous system progenitors...

More Information

Publications62

  1. Hu J, Peng X, Cladel N, Pickel M, Christensen N. Large cutaneous rabbit papillomas that persist during cyclosporin A treatment can regress spontaneously after cessation of immunosuppression. J Gen Virol. 2005;86:55-63 pubmed
    ..However, returning immunity can lead to regression and clearance of large papillomas (with increased antigenicity) in an outbred population, whilst these same antigenic papillomas persist in inbred rabbits...
  2. Lupp A, Kuhn U, Herwig R, Karge E, Rost M, Scheele J, et al. Cyclosporine A and tacrolimus: in vitro investigations on the differential interactions with the cytochrome P450 system in rat and human liver. Exp Toxicol Pathol. 2003;54:467-73 pubmed
  3. Luo L, Xu S. Mapping viability loci using molecular markers. Heredity (Edinb). 2003;90:459-67 pubmed
    ..We conclude that mapping viability loci can be accomplished using similar statistical techniques used in quantitative trait locus mapping for quantitative traits...
  4. Lintunen M, Raatesalmi K, Sallmen T, Anichtchik O, Karlstedt K, Kaslin J, et al. Low brain histamine content affects ethanol-induced motor impairment. Neurobiol Dis. 2002;9:94-105 pubmed
    ..Brain histamine levels and possibly signaling via H3 receptors may thus correlate with genetic differences in ethanol-induced motor impairment...
  5. Li J, Kajiya H, Okamoto F, Nakao A, Iwamoto T, Okabe K. Three Na+/Ca2+ exchanger (NCX) variants are expressed in mouse osteoclasts and mediate calcium transport during bone resorption. Endocrinology. 2007;148:2116-25 pubmed
    ..These results show that three NCX variants are expressed in mouse osteoclasts and play an important role for Ca(2+) transport and regulation during osteoclastic bone resorption...
  6. Cruz F, Quadros I, Planeta C, Miczek K. Maternal separation stress in male mice: long-term increases in alcohol intake. Psychopharmacology (Berl). 2008;201:459-68 pubmed publisher
    ..In rodents, prolonged maternal separation has been used as a model of developmentally early environmental stress to influence adult drug intake...
  7. Noel S, Sharma S, Shanker R, Rath S. Primaquine-induced differential gene expression analysis in mice liver using DNA microarrays. Toxicology. 2007;239:96-107 pubmed
    ..These results indicate that PQ at high doses may affect gene expression in liver and may produce undesirable outcomes if consumed for longer durations...
  8. Woicke J, Durham S, Mense M. Lobucavir-induced proliferative changes in mice. Exp Toxicol Pathol. 2007;59:197-204 pubmed
    ..These results suggest that long-term administration of lobucavir causes neoplasia in mice, the spectrum of which resembles that observed after long-term administration of zidovudine or ganciclovir...
  9. Cipollone D, Carsetti R, Tagliani A, Rosado M, Borgiani P, Novelli G, et al. Folic acid and methionine in the prevention of teratogen-induced congenital defects in mice. Cardiovasc Pathol. 2009;18:100-9 pubmed publisher
    ..Hereby, we analyzed the effects of nutritive therapy involving folic acid and methionine on teratogen-induced congenital defects in mice...
  10. Perazzo J, Boviez J, Lago N, Diaz S. Growth and reproductive problems in a colony of laboratory rats. Diagnosis: Mycotoxin poisoning. Lab Anim (NY). 2008;37:153-5 pubmed publisher
  11. Vakhitova I, Iamidanov R, Seredinin S. [Ladasten induces the expression of genes regulating dopamine biosynthesis in various structures of rat brain]. Eksp Klin Farmakol. 2004;67:7-11 pubmed
    ..There is a certain difference in the ladasten action upon the TH and DDC gene expression of the key enzymes in hypothalamus and striatum of rat brain...
  12. Strand S, Leib D. Role of the VP16-binding domain of vhs in viral growth, host shutoff activity, and pathogenesis. J Virol. 2004;78:13562-72 pubmed
    ..It is required, however, for RNA degradation activity of tegument-derived vhs and wild-type replication and virulence in mice...
  13. Weerkamp F, Luis T, Naber B, Koster E, Jeannotte L, van Dongen J, et al. Identification of Notch target genes in uncommitted T-cell progenitors: No direct induction of a T-cell specific gene program. Leukemia. 2006;20:1967-77 pubmed
    ..Apparently, Notch signaling is essential to open the T-cell pathway, but does not initiate the T-cell program itself...
  14. Fernández Lago L, Orduña A, Vizcaino N. Reduced interleukin-18 secretion in Brucella abortus 2308-infected murine peritoneal macrophages and in spleen cells obtained from B. abortus 2308-infected mice. J Med Microbiol. 2005;54:527-31 pubmed
    ..These data suggest that once the infection has been established, B. abortus 2308 selectively limits IL-18 secretion without affecting endogenous IFN-gamma production...
  15. Li W, Liu X, Xu R, Zhang Y. Immunolocalization assessment of metastasis-associated protein 1 in human and mouse mature testes and its association with spermatogenesis. Asian J Androl. 2007;9:345-52 pubmed
    ..To investigate the stage-specific localization of metastasis-associated protein 1 (MTA1) during spermatogenesis in adult human and mouse testis...
  16. Takahashi S, Egawa Y, Simojo N, Tsukahara T, Ushida K. Oral administration of Lactobacillus plantarum strain Lq80 to weaning piglets stimulates the growth of indigenous lactobacilli to modify the lactobacillal population. J Gen Appl Microbiol. 2007;53:325-32 pubmed
    ..The oral administration of L. plantarum strain Lq80 was effective to stimulate the development of the lactobacillal population in the intestine of post-weaning piglets...
  17. Saran A, Zaffaroni D, Pazzaglia S, Peissel B, Galbiati F, Spinola M, et al. Inhibition of both skin and lung tumorigenesis by Car-R mouse-derived cancer modifier loci. Int J Cancer. 2002;97:580-3 pubmed
  18. Fazeli A, Affara N, Hubank M, Holt W. Sperm-induced modification of the oviductal gene expression profile after natural insemination in mice. Biol Reprod. 2004;71:60-5 pubmed
    ..These results indicate that it is the arrival of spermatozoa in the oviduct that activates one or more signal transduction pathways and leads to changes in the oviductal transcriptome profiles...
  19. Scibior A, Zaporowska H, Niedźwiecka I. Lipid peroxidation in the liver of rats treated with V and/or Mg in drinking water. J Appl Toxicol. 2009;29:619-28 pubmed publisher
  20. Wang Q, Zheng Y, Lu J, Chen L, Wang G, Zhou J. Isoflurane potency in mice from the first and second parity. J Am Assoc Lab Anim Sci. 2009;48:714-7 pubmed
    ..These results indicate that offspring in the second litter from the same parents can be used for stock conservation and anesthesia research...
  21. Partadiredja G, Bedi K. Undernutrition during either the pre- or immediate post-weaning period does not affect longevity in Quackenbush mice. Nutr Neurosci. 2010;13:33-42 pubmed publisher
    ..However, there was some evidence that, if it occurred, serious illness happened at a younger age in the well-nourished mice than those in the two diet-restricted groups...
  22. Marceau M, Sebbane F, Ewann F, Collyn F, Lindner B, Campos M, et al. The pmrF polymyxin-resistance operon of Yersinia pseudotuberculosis is upregulated by the PhoP-PhoQ two-component system but not by PmrA-PmrB, and is not required for virulence. Microbiology. 2004;150:3947-57 pubmed
    ..typhimurium. The marked differences in pmrF operon regulation in these two phylogenetically close bacterial species may be related to their dissimilar lifestyles...
  23. Escobar J, Jarne P, Charmantier A, David P. Outbreeding alleviates senescence in hermaphroditic snails as expected from the mutation-accumulation theory. Curr Biol. 2008;18:906-10 pubmed publisher
    ..We provide new theoretical models showing this to be another consequence of MA. Our results offer interesting perspectives on how different populations may follow different genetic pathways to evolve senescence...
  24. Vines R, Perdue S, Moncrief J, Sentz D, Barroso L, Wright R, et al. Fragilysin, the enterotoxin from Bacteroides fragilis, enhances the serum antibody response to antigen co-administered by the intranasal route. Vaccine. 2000;19:655-60 pubmed
    ..Our results and similar studies with enterotoxins that affect the paracellular barrier suggest that alteration of mucosal permeability may play an important role in the mechanisms of adjuvanticity...
  25. Tewari R, Dorin D, Moon R, Doerig C, Billker O. An atypical mitogen-activated protein kinase controls cytokinesis and flagellar motility during male gamete formation in a malaria parasite. Mol Microbiol. 2005;58:1253-63 pubmed
  26. Blinkhorn S. Neuroscience: of mice and mentality. Nature. 2003;424:1004-5 pubmed
  27. Piña Guzmán B, Solís Heredia M, Rojas García A, Uriostegui Acosta M, Quintanilla Vega B. Genetic damage caused by methyl-parathion in mouse spermatozoa is related to oxidative stress. Toxicol Appl Pharmacol. 2006;216:216-24 pubmed
    ..These findings suggest a potential risk of Me-Pa to the offspring after transmission...
  28. Johannesson M, Lopez Aumatell R, Stridh P, Diez M, Tuncel J, Blázquez G, et al. A resource for the simultaneous high-resolution mapping of multiple quantitative trait loci in rats: the NIH heterogeneous stock. Genome Res. 2009;19:150-8 pubmed publisher
  29. Donadieu E, Hamdi W, Deveze A, Lucciano M, Lavieille J, Magnan J, et al. Improved cryosections and specific immunohistochemical methods for detecting hypoxia in mouse and rat cochleae. Acta Histochem. 2007;109:177-84 pubmed
  30. Kloting I, Nitschke C, van den Brandt J. Impact of genetic profiles on experimental studies: outbred versus wild rats. Toxicol Appl Pharmacol. 2003;189:68-71 pubmed
  31. Görisch J, Schwarting R. Wistar rats with high versus low rearing activity differ in radial maze performance. Neurobiol Learn Mem. 2006;86:175-87 pubmed
    ..These results are discussed with respect to the role of cognitive and motivational mechanisms, which as subject-inherent factors can contribute substantially to inter-individual variability in the radial maze...
  32. Harikai N, Tomogane K, Sugawara T, Tashiro S. Differences in hypothalamic Fos expressions between two heat stress conditions in conscious mice. Brain Res Bull. 2003;61:617-26 pubmed
    ..These results support that the activated regions in hypothalamus differed with heat stress conditions, which induced only hyperthermia and both hyperthermia and dehydration...
  33. Kaminsky Z, Tang T, Wang S, Ptak C, Oh G, Wong A, et al. DNA methylation profiles in monozygotic and dizygotic twins. Nat Genet. 2009;41:240-5 pubmed publisher
  34. Shreder O, Smolnikova N, Durnev A, Seredenin S. Effect of afobazole on teratogenic activity of cyclophosphamide in rats. Bull Exp Biol Med. 2008;145:436-9 pubmed
    ..Our results suggest that afobazole possesses antiteratogenic activity...
  35. Johri A, Padilla J, Malin G, Paoletti L. Oxygen regulates invasiveness and virulence of group B streptococcus. Infect Immun. 2003;71:6707-11 pubmed
    ..8 h, with oxygen) was more virulent in neonatal mice than was GBS grown under suboptimal invasion conditions (t(d) of 1.8 h, without oxygen), suggesting a positive association between in vitro invasiveness with DIVAS and virulence...
  36. Gordon J, Wolanin P, Gonzalez A, Fela D, Sarngadharan G, Rouzard K, et al. Topical N-acetyl-S-farnesyl-L-cysteine inhibits mouse skin inflammation, and unlike dexamethasone, its effects are restricted to the application site. J Invest Dermatol. 2008;128:643-54 pubmed
    ..This was much less than the 90% inhibition of neutrophil infiltration, suggesting that AFC does not act by directly inhibiting protein kinase C...
  37. da Silva M, Nobrega A, Ribeiro R, Levy M, Ribeiro O, Tambourgi D, et al. Genetic selection for resistance or susceptibility to oral tolerance imparts correlation to both Immunoglobulin E level and mast cell number phenotypes with a profound impact on the atopic potential of the individual. Clin Exp Allergy. 2006;36:1399-407 pubmed
  38. Puopolo K, Madoff L. Upstream short sequence repeats regulate expression of the alpha C protein of group B Streptococcus. Mol Microbiol. 2003;50:977-91 pubmed
    ..This is the first evidence of transcriptional regulation by short-sequence repeats in a Gram-positive organism...
  39. Luo C, Lin H, Gopinath S, Chen Y. Distinction of sperm-binding site and reactive site for trypsin inhibition on p12 secreted from the accessory sex glands of male mice. Biol Reprod. 2004;70:965-71 pubmed
    ..The steric arrangement of R19, Y21, and D22 on the tertiary structure of P12 is discussed...
  40. Bruchajzer E, Szymanska J, Piotrowski J. Acute and subacute nephrotoxicity of 2-bromophenol in rats. Toxicol Lett. 2002;134:245-52 pubmed
    ..However, the transition from single to repeated exposure does not result in enhanced nephrotoxicity...
  41. Joshi M, Fehlings M. Development and characterization of a novel, graded model of clip compressive spinal cord injury in the mouse: Part 1. Clip design, behavioral outcomes, and histopathology. J Neurotrauma. 2002;19:175-90 pubmed
    ..05, SNK test). This novel, graded compressive model of SCI will facilitate future studies of the pathological mechanisms of SCI using transgenic and knockout murine systems...
  42. Ramos R, Smith P, DeCola C, Tam D, Corzo O, Brumberg J. Cytoarchitecture and transcriptional profiles of neocortical malformations in inbred mice. Cereb Cortex. 2008;18:2614-28 pubmed publisher
    ..Furthermore, the presence of dysplasia in nearly every inbred strain examined suggests that malformations of neocortical development are a common feature in the neocortex of inbred mice...
  43. Kyselova V, Peknicova J, Buckiova D, Boubelik M. Effects of p-nonylphenol and resveratrol on body and organ weight and in vivo fertility of outbred CD-1 mice. Reprod Biol Endocrinol. 2003;1:30 pubmed
    ..The litter sex ratio was not different from controls. Unlike RES, NP had a negative effect on spermatogenesis and sperm quality with a resultant impact on in vivo fertility...
  44. Pisarska M, Bae J, Klein C, Hsueh A. Forkhead l2 is expressed in the ovary and represses the promoter activity of the steroidogenic acute regulatory gene. Endocrinology. 2004;145:3424-33 pubmed
  45. Shibamoto T, Cui S, Ruan Z, Kurata Y. Effects of norepinephrine and histamine on vascular resistance in isolated perfused mouse liver. Jpn J Physiol. 2005;55:143-8 pubmed
    ..In conclusion, the presinusoidal and postsinusoidal resistances of mouse livers were similar in magnitude. The presinusoidal vessels predominantly contract in response to norepinephrine and histamine in mouse livers...
  46. Chia R, Achilli F, Festing M, Fisher E. The origins and uses of mouse outbred stocks. Nat Genet. 2005;37:1181-6 pubmed
    ..Here we assess the most widely used outbred stocks of mice and present guidelines for their use...
  47. Adwanikar H, Karim F, Gereau R. Inflammation persistently enhances nocifensive behaviors mediated by spinal group I mGluRs through sustained ERK activation. Pain. 2004;111:125-35 pubmed
  48. Oshio K, Binder D, Yang B, Schecter S, Verkman A, Manley G. Expression of aquaporin water channels in mouse spinal cord. Neuroscience. 2004;127:685-93 pubmed
    ..The aquaporin expression pattern in spinal cord suggests involvement in water homeostasis and diseases associated with abnormal water fluxes such as spinal cord injury and syringomyelia...
  49. Chiou T, Chu S, Tzeng W, Huang Y, Liao C. Arsenic trioxide impairs spermatogenesis via reducing gene expression levels in testosterone synthesis pathway. Chem Res Toxicol. 2008;21:1562-9 pubmed publisher
    ..3 and 1.5 mg/kg body weight. We concluded that As2O3 treatment caused damage to sperm mobility and viability. As2O3 treatment disturbed spermatogenesis via reducing gene expression of the key enzymes in testosterone synthesis...
  50. Suzuki H, Suzuki Y, Yamanaka T, Hirose S, Nishimura H, Toei J, et al. Genome-wide scan in a novel IgA nephropathy model identifies a susceptibility locus on murine chromosome 10, in a region syntenic to human IGAN1 on chromosome 6q22-23. J Am Soc Nephrol. 2005;16:1289-99 pubmed
    ..In conclusion, the three-group ddY mouse model can be a useful tool for identifying the susceptibility genes and also to examine their roles in the pathogenesis of IgAN...
  51. Sandland G, Foster A, Zavodna M, Minchella D. Interplay between host genetic variation and parasite transmission in the Biomphalaria glabrata-Schistosoma mansoni system. Parasitol Res. 2007;101:1083-9 pubmed
    ..This work shows that the introduction of genetic variation into inbred snail populations can have important implications for the viability of host populations and disease transmission...
  52. Su Y, Xiong Y, Zhang Q, Xia X, Jiang S, Deng C, et al. [Construction of linkage map of chromosomes 1 and 3 in large white x Meishan reference family]. Yi Chuan Xue Bao. 2002;29:16-20 pubmed
    ..There were some differences between the linkage maps in this study and of USDA-MARC. The linkage map of chromosome 1 in female was found to be shorter than in male, and the contrary was on chromosome 3...
  53. Curado S, Stainier D. The HeArt of regeneration. Cell. 2006;127:462-4 pubmed
    ..analyze regeneration in the zebrafish heart. Their work indicates that new cardiomyocytes originate from undifferentiated progenitor cells and reveals a critical role for the epicardium, the cellular layer that covers the heart...