inbred wf rats


Summary: An inbred strain of rat that is used in BIOMEDICAL RESEARCH.

Top Publications

  1. Hosenpud J, Boyle T, Hensler H, Sanford G, Khanna A. The relationship between acute rejection and chronic rejection is highly dependent on specific MHC matching: a multi-strain rat heterotopic heart transplant study. Transplantation. 2000;69:2173-8 pubmed
    ..Furthermore, the ideal animal model, which duplicates as well as controls for this immunologic heterogeneity, is lacking...
  2. Woditschka S, Haag J, Waller J, Monson D, Hitt A, Brose H, et al. Neu-induced retroviral rat mammary carcinogenesis: a novel chemoprevention model for both hormonally responsive and nonresponsive mammary carcinomas. Cancer Res. 2006;66:6884-91 pubmed
    ..The model is useful for assessing the efficacy of chemopreventive agents, specifically those compounds that target hormonally nonresponsive tumors...
  3. John R, Rezaeipoor R, Adie S, Chaney E, Oldenburg A, Marjanovic M, et al. In vivo magnetomotive optical molecular imaging using targeted magnetic nanoprobes. Proc Natl Acad Sci U S A. 2010;107:8085-90 pubmed publisher
    ..These engineered magnetic nanoprobes have multifunctional capabilities enabling them to be used as dynamic contrast agents in MM-OCT and MRI...
  4. Chen W, Adams R, Carubelli R, Nordquist R. Laser-photosensitizer assisted immunotherapy: a novel modality for cancer treatment. Cancer Lett. 1997;115:25-30 pubmed
    ..These findings indicate that our treatment has triggered a specific humoral immune response in the tumor-bearing rats...
  5. Renkonen R, Fukuda M, Petrov L, Paavonen T, Renkonen J, Hayry P, et al. A peptide mimic of selectin ligands abolishes in vivo inflammation but has no effect on the rat heart allograft survival1. Transplantation. 2002;74:2-6 pubmed
    ..These data indicate that the intensity of inflammation related to the allograft rejection does not correlate to the graft survival. ..
  6. Frese K, Lee S, Thomas D, Latorre I, Weiss R, Glaunsinger B, et al. Selective PDZ protein-dependent stimulation of phosphatidylinositol 3-kinase by the adenovirus E4-ORF1 oncoprotein. Oncogene. 2003;22:710-21 pubmed
    ..From these results, we propose that the transforming and tumorigenic potentials of the adenovirus E4-ORF1 oncoprotein depend on its capacity to activate PI3K through a novel PDZ protein-dependent mechanism of action. ..
  7. Carlsson P, Mattsson G. Oxygen tension and blood flow in relation to revascularization in transplanted adult and fetal rat pancreatic islets. Cell Transplant. 2002;11:813-20 pubmed
    ..Similar low oxygen tension and vascular density are seen in grafted fetal islets. The amount of VEGF production does not correlate to the degree of revascularization of the grafts. ..
  8. Garcia Y, Pothitakis J, Krolick K. Myocyte production of nitric oxide in response to AChR-reactive antibodies in two inbred rat strains may influence disease outcome in experimental myasthenia gravis. Clin Immunol. 2003;106:116-26 pubmed
    ..It is speculated that nitric oxide production plays a protective immunomodulating role in WF rats. ..
  9. Jin Y, Zhang Q, Hao J, Gao X, Guo Y, Xie S. Simultaneous administration of a low-dose mixture of donor bone marrow cells and splenocytes plus adenovirus containing the CTLA4Ig gene result in stable mixed chimerism and long-term survival of cardiac allograft in rats. Immunology. 2003;110:275-86 pubmed

More Information

Publications112 found, 100 shown here

  1. Rasmussen S, Sørensen T, Hansen J, Mandrup Poulsen T, Hornum L, Markholst H. Functional rest through intensive treatment with insulin and potassium channel openers preserves residual beta-cell function and mass in acutely diabetic BB rats. Horm Metab Res. 2000;32:294-300 pubmed
    ..These results imply that it is conceivable to preserve residual beta-cells at diabetes onset by induction of target cell rest with potassium channel openers and continuous insulin treatment. ..
  2. Young H, Duplaa C, Yost M, Henson N, Floyd J, Detmer K, et al. Clonogenic analysis reveals reserve stem cells in postnatal mammals. II. Pluripotent epiblastic-like stem cells. Anat Rec A Discov Mol Cell Evol Biol. 2004;277:178-203 pubmed
    ..This study suggests that embryonic-like stem cells are retained within postnatal mammals and have the potential for use in gene therapy and tissue engineering. ..
  3. Rintala J, Savikko J, Rintala S, von Willebrand E. The effect of FK778 on acute rat renal allograft rejection and expression of platelet-derived growth factor and transforming growth factor-beta. Transplant Proc. 2006;38:2719-21 pubmed
    ..Our results indicated that FK778 decreased PDGF and TGF-beta expression early in acute rejection, suggesting it to be a promising therapy for CAN. ..
  4. Krebs R, Hollmén M, Tikkanen J, Wu Y, Hicklin D, Koskinen P, et al. Vascular endothelial growth factor plays a major role in development of experimental obliterative bronchiolitis. Transplant Proc. 2006;38:3266-7 pubmed
    ..When compared with the control immunoglobulin (Ig)G group, simultaneous treatment with antibodies against VEGFR-1 and -2 significantly lowered the degree of luminal occlusion of mouse tracheal allografts. ..
  5. Gomes A, Haldar S, Giri B, Mishra R, Saha A, Dasgupta S, et al. Experimental osteoporosis induced in female albino rats and its antagonism by Indian black scorpion (Heterometrus bengalensis C.L.Koch) venom. Toxicon. 2009;53:60-8 pubmed publisher
    ..This study confirms that the Indian black scorpion venom may influence bone remodeling process by stimulating bone formation and reducing bone resorption process of osteogenesis. ..
  6. Noris M, Cugini D, Casiraghi F, Azzollini N, De Deus Viera Moraes L, Mister M, et al. Thymic microchimerism correlates with the outcome of tolerance-inducing protocols for solid organ transplantation. J Am Soc Nephrol. 2001;12:2815-26 pubmed
    ..This effect appears to occur through migration of donor MHCII(+) cells in the host thymus. ..
  7. Hessner M, Wang X, Meyer L, Geoffrey R, Jia S, Fuller J, et al. Involvement of eotaxin, eosinophils, and pancreatic predisposition in development of type 1 diabetes mellitus in the BioBreeding rat. J Immunol. 2004;173:6993-7002 pubmed
    ..These data support an important role for these inflammatory mediators in BB rat T1DM and suggest that the lymphopenia due to the Ian5/(lyp) mutation may result in a deregulation of cells involved in insulitis and beta cell destruction...
  8. Potiron N, Chagneau C, Boeffard F, Soulillou J, Anegon I, Le Mauff B. Adenovirus-mediated CTLA4Ig or CD40Ig gene transfer delays pancreatic islet rejection in a rat-to-mouse xenotransplantation model after systemic but not local expression. Cell Transplant. 2005;14:263-75 pubmed
    ..These results contrast with the efficacy of AdCTLA4Ig we observed in a rat islet allotransplantation model and suggest that islet xenograft rejection might be more difficult to control. ..
  9. Fong M, Darendeliler M, Hunter N, Shen G. Epithelial cells in PDL are critical in resuming the integral relation between tooth root and supporting bone after trauma--a transplantation experiment. Arch Oral Biol. 2007;52:182-8 pubmed
    ..Residual PDL is essential to prevent ankylosis after trauma and epithelial cells may facilitate the re-establishment of root-PDL-bone complex by transforming into mesenchymal cells. ..
  10. Timm S, Otto C, Hamelmann W, Gassel A, Timmermann W, Ulrichs K, et al. Rat parathyroid allotransplantation: Influence of MHC antigen expression on graft survival. Microsurgery. 2001;21:221-2 pubmed
    ..These results indicate that immunogenicity of rat parathyroid tissue might be determined by the amount of MHC class I expressed in donor parenchymal cells. Further experiments are necessary to validate this observation. ..
  11. Bogazzi F, Ultimieri F, Raggi F, Russo D, Vanacore R, Guida C, et al. PPARgamma inhibits GH synthesis and secretion and increases apoptosis of pituitary GH-secreting adenomas. Eur J Endocrinol. 2004;150:863-75 pubmed
  12. Nicolas M, Lesage F, Reyes R, Barhanin J, Demêmes D. Localization of TREK-1, a two-pore-domain K+ channel in the peripheral vestibular system of mouse and rat. Brain Res. 2004;1017:46-52 pubmed
    ..TREK-1 may subserve some neuroprotective function in afferent nerve fibers as well as play a role in endolymph potassium homeostasis. ..
  13. Stegbauer J, Vonend O, Oberhauser V, Sellin L, Rump L. Angiotensin II receptor modulation of renal vascular resistance and neurotransmission in young and adult spontaneously hypertensive rats. Kidney Blood Press Res. 2005;28:20-6 pubmed
    ..All effects are mediated by the AT1 receptor and no modulatory influence of the AT2 receptor could be found. ..
  14. Nilakantan V, Zhou X, Hilton G, Roza A, Adams M, Johnson C, et al. Hierarchical change in antioxidant enzyme gene expression and activity in acute cardiac rejection: role of inducible nitric oxide synthase. Mol Cell Biochem. 2005;270:39-47 pubmed
    ..This suggests a differential role for iNOS in regulating post-translational modification of individual antioxidant enzymes in acute cardiac transplantation. ..
  15. Liu Y, Bledsoe G, Hagiwara M, Yang Z, Shen B, Chao L, et al. Blockade of endogenous tissue kallikrein aggravates renal injury by enhancing oxidative stress and inhibiting matrix degradation. Am J Physiol Renal Physiol. 2010;298:F1033-40 pubmed publisher
    ..These findings indicate that endogenous TK has the propensity to preserve kidney structure and function in rats with chronic renal disease by inhibiting oxidative stress and activating matrix degradation pathways. ..
  16. Buvall L, Bollano E, Chen J, Shultze W, Fu M. Phenotype of early cardiomyopathic changes induced by active immunization of rats with a synthetic peptide corresponding to the second extracellular loop of the human beta-adrenergic receptor. Clin Exp Immunol. 2006;143:209-15 pubmed
  17. Christensen U, Larsen P, Fey S, Karlsen A, Pociot F, Nerup J, et al. Different islet protein expression profiles during spontaneous diabetes development vs. allograft rejection in BB-DP rats. Autoimmunity. 2006;39:315-21 pubmed
    ..Whether this reflects activation of distinct signalling pathways in islet cells is currently unknown and need to be further investigated. ..
  18. Hirano M, Rakwal R, Kouyama N, Katayama Y, Hayashi M, Shibato J, et al. Gel-based proteomics of unilateral irradiated striatum after gamma knife surgery. J Proteome Res. 2007;6:2656-68 pubmed
    ..Taken together, these results indicate that unilateral irradiation during GKS triggers molecular changes in the bilateral striata. ..
  19. Friederich M, Fasching A, Hansell P, Nordquist L, Palm F. Diabetes-induced up-regulation of uncoupling protein-2 results in increased mitochondrial uncoupling in kidney proximal tubular cells. Biochim Biophys Acta. 2008;1777:935-40 pubmed publisher
    ..This mechanism may be protective against diabetes-induced oxidative stress, but will increase O(2) usage. The subsequently reduced O(2) availability may contribute to diabetes-induced progressive kidney damage. ..
  20. Wang H, Shi F, Li H, van der Meide P, Ljunggren H, Link H. Role for interferon-gamma in rat strains with different susceptibility to experimental autoimmune myasthenia gravis. Clin Immunol. 2000;95:156-62 pubmed
    ..We conclude that IFN-gamma plays a major role in the pathogenesis of EAMG in the Lewis rat, but fails to break disease resistance in the WF rat. ..
  21. Nikolic B, Cooke D, Zhao G, Sykes M. Both gamma delta T cells and NK cells inhibit the engraftment of xenogeneic rat bone marrow cells and the induction of xenograft tolerance in mice. J Immunol. 2001;166:1398-404 pubmed
    ..2 and anti-NK1.1 mAbs in TCRdelta(-/-) mice. Therefore, in addition to CD4 and CD8 T cells, gammadelta T cells and NK cells play a role in resisting engraftment of rat marrow and the induction of xenograft tolerance in mice. ..
  22. He W, Halberstadt C, Gonsalves K. Lithography application of a novel photoresist for patterning of cells. Biomaterials. 2004;25:2055-63 pubmed
    ..Fibroblast cells were observed to align on the patterned surface. This resist could be a suitable candidate to improve the application of conventional lithography in direct protein patterning for the guided growth of cells. ..
  23. Hirano M, Tanuma J, Hirayama Y, Ohyama M, Semba I, Wakusawa S, et al. A speed congenic rat strain bearing the tongue cancer susceptibility locus Tscc1 from Dark-Agouti rats. Cancer Lett. 2006;231:185-91 pubmed
    ..Possible relevance of NQO1 polymorphism to TC susceptibility is discussed. ..
  24. Kallio E, Lemström K, Hayry P, Ryan U, Koskinen P. Blockade of complement inhibits obliterative bronchiolitis in rat tracheal allografts. Am J Respir Crit Care Med. 2000;161:1332-9 pubmed
    ..A blockade of complement activation renders the chemokine milieu unattractive to neutrophils and also modulates the alloimmune response toward Th2 cytokines, which may have an antiproliferative role in fibroproliferative disorders. ..
  25. Lan H, Kendziorski C, Haag J, Shepel L, Newton M, Gould M. Genetic loci controlling breast cancer susceptibility in the Wistar-Kyoto rat. Genetics. 2001;157:331-9 pubmed
    ..In addition, we identified an interaction between Mcs8 and a region on chromosome 6 termed Mcsm1 (modifier of Mcs), which had no significant main effect on mammary cancer susceptibility in this genetic analysis. ..
  26. Sitaru A, Timmermann W, Ulrichs K, Otto C. Allogeneic core amino acids of an immunodominant allopeptide are important for MHC binding and TCR recognition. Hum Immunol. 2004;65:817-25 pubmed
    ..Identification of MHC and TCR contact residues should facilitate the development of antigen-specific therapies to inhibit or regulate the indirect alloimmune response. ..
  27. Jariyapongskul A, Rungjaroen T, Kasetsuwan N, Patumraj S, Seki J, Niimi H. Long-term effects of oral vitamin C supplementation on the endothelial dysfunction in the iris microvessels of diabetic rats. Microvasc Res. 2007;74:32-8 pubmed
    ..The antioxidant vitamin C may be a therapeutic agent for preventing diabetic retinopathy. ..
  28. Semiletova N, Shen X, Feldman D, Gao F, Mhoyan A, Liu D, et al. Class I MHC allochimeric presentation of composite immunogenic and self epitopes induces tolerance to genetically diverse rat strains. Cell Immunol. 2007;248:48-58 pubmed
  29. LeBedis C, Chen K, Fallavollita L, Boutros T, Brodt P. Peripheral lymph node stromal cells can promote growth and tumorigenicity of breast carcinoma cells through the release of IGF-I and EGF. Int J Cancer. 2002;100:2-8 pubmed
    ..The identification of these cells raises the possibility that the lymph node microenvironment may contribute actively to the process of cancer cell dissemination. ..
  30. Jesmin S, Sakuma I, Hattori Y, Kitabatake A. Regulatory molecules for coronary expressions of VEGF and its angiogenic receptor KDR in hypoestrogenic middle-aged female rats. Mol Cell Biochem. 2004;259:189-96 pubmed
    ..We reached a conclusion that the VEGF-KDR system plays a key role in coronary angiogenesis in hypoestrogenic elderly women and is critically regulated by estrogen, eNOS and HIF-1alpha. ..
  31. Goepfert T, Moreno Smith M, Edwards D, Pathak S, Medina D, Brinkley W. Loss of chromosomal integrity drives rat mammary tumorigenesis. Int J Cancer. 2007;120:985-94 pubmed
    ..Collectively, these data suggest that the carcinogen MNU induces changes resulting in genetic instability detectable before hyperplasia and tumors develop in the rat mammary gland. ..
  32. Kosacka J, Gericke M, Nowicki M, Kacza J, Borlak J, Spanel Borowski K. Apolipoproteins D and E3 exert neurotrophic and synaptogenic effects in dorsal root ganglion cell cultures. Neuroscience. 2009;162:282-91 pubmed publisher
    ..We thus assume that apolipoprotein-induced neuritogenesis in DRG cells interferes with CXCR4 signaling, and that adipocyte-derived apolipoproteins might be helpful in nerve repair. ..
  33. Prpić Mehicić G, Marsan T, Miletic I, Buntak Kobler D. Infective endocarditis caused by Veillonella of dental origin. Coll Antropol. 1998;22 Suppl:39-43 pubmed
    ..In conclusion, on the rats model Veillonella can penetrate into circulation in association with S. mutans via the pulp tissue and could be involved in infective endocarditis. ..
  34. Boyle M, Dumble L. 15AU81, a prostacyclin analog, enhances donor-specific hepatocytes to prolong the survival of rat heart but not small bowel allografts. Cell Transplant. 1999;8:543-8 pubmed
    ..The failure to enhance small bowel allograft survival may be explained by the inability at this low dosage of 15AU81 to influence the intense graft versus host reaction elicited by small bowel transplants. ..
  35. Tliba O, Sibille P, Boulard C, Chauvin A. Early hepatic cytokine mRNA expression in experimental rat fasciolosis. Vet Parasitol. 2002;103:237-49 pubmed
    ..In the spleen, cytokine down-regulation was initiated and maintained during this period, suggesting that the parasite acts differently locally and in the periphery. ..
  36. Hammer M, Schröder G, Risch K, Flügel A, Volk H, Lehmann M, et al. Antigen-dependent transgene expression in kidney transplantation: a novel approach using gene-engineered T lymphocytes. J Am Soc Nephrol. 2002;13:511-8 pubmed
    ..Antigen-specific gene-targeting strategies using ex vivo modified T lymphocytes with donor specificity are a novel approach to the delivery of therapeutic transgenes in transplantation. ..
  37. Foster R, Pham S, Li S, Aitouche A. Long-term acceptance of composite tissue allografts through mixed chimerism and CD28 blockade. Transplantation. 2003;76:988-94 pubmed
  38. Carlsson P, Palm F. Oxygen tension in isolated transplanted rat islets and in islets of rat whole-pancreas transplants. Transpl Int. 2002;15:581-5 pubmed
    ..The lower oxygen tension in transplanted isolated islets may be one explanation for the more frequent failures of transplanted islets compared with the outcome when the whole pancreatic gland is transplanted. ..
  39. Mayhan W. Pial vessel permeability to tracers using cranial windows. Methods Mol Med. 2003;89:121-31 pubmed
  40. Williams K, Standfield S, Smith J, Coster D. Corneal graft rejection occurs despite Fas ligand expression and apoptosis of infiltrating cells. Br J Ophthalmol. 2005;89:632-8 pubmed
    ..Despite the death of the cells believed to be responsible for rejection, isografts survive indefinitely whereas allografts are irreparably damaged. ..
  41. Bullmann T, de Silva R, Holzer M, Mori H, Arendt T. Expression of embryonic tau protein isoforms persist during adult neurogenesis in the hippocampus. Hippocampus. 2007;17:98-102 pubmed
    ..A model for studying shifts in tau isoform expression in a defined subset of neurons might help to understand the etiology of tauopathies, when isoform composition is crucial for neurodegeneration, as in Pick's disease or FTDP-17. ..
  42. Vela J, Perez Millan M, Becu Villalobos D, Diaz Torga G. Different kinases regulate activation of voltage-dependent calcium channels by depolarization in GH3 cells. Am J Physiol Cell Physiol. 2007;293:C951-9 pubmed
  43. Santos P, Santos I, Nahas F, Oliveira Filho R, Ferreira L. National equipment of intraoperatory gamma detection in the identification of sentinel lymph node in animal model. Acta Cir Bras. 2009;24:195-9 pubmed
    ..The Cronbach alpha has shown high internal consistency of data 0.9416. The national equipment of intraoperatory gamma detection identifies the LS and showed false positives LS and needs improvement. ..
  44. DePaz H, Oluwole O, Adeyeri A, Witkowski P, Jin M, Hardy M, et al. Immature rat myeloid dendritic cells generated in low-dose granulocyte macrophage-colony stimulating factor prolong donor-specific rat cardiac allograft survival. Transplantation. 2003;75:521-8 pubmed
    ..This finding suggests that immunization with immature donor DCs has therapeutic potential for the induction of transplant tolerance and treatment of autoimmune diseases. ..
  45. Strom A, Wang G, Reimer R, Finegood D, Scott F. Pronounced cytosolic aggregation of cellular prion protein in pancreatic beta-cells in response to hyperglycemia. Lab Invest. 2007;87:139-49 pubmed
    ..These data suggest a potential dysfunction in beta-cells of diabetes-prone rats, and point to new avenues for the study of diabetes pathogenesis. ..
  46. Eaton M, Martinez M, Karmally S. A single intrathecal injection of GABA permanently reverses neuropathic pain after nerve injury. Brain Res. 1999;835:334-9 pubmed
    ..This suggests that altered spinal GABA levels contribute to the induction phase of chronic neuropathic pain and that early intervention to restore GABA may prevent the development of that pain...
  47. Horton J, Maass D, White J, Sanders B. Hypertonic saline-dextran suppresses burn-related cytokine secretion by cardiomyocytes. Am J Physiol Heart Circ Physiol. 2001;280:H1591-601 pubmed
    ..These data suggest that HSD mediates cardioprotection after burn trauma, in part, by downregulating cardiomyocyte secretion of inflammatory cytokines...
  48. Engelhard H, Duncan H, Kim S, Criswell P, Van Eldik L. Therapeutic effects of sodium butyrate on glioma cells in vitro and in the rat C6 glioma model. Neurosurgery. 2001;48:616-24; discussion 624-5 pubmed
  49. Le Berre L, Godfrin Y, Günther E, Buzelin F, Perretto S, Smit H, et al. Extrarenal effects on the pathogenesis and relapse of idiopathic nephrotic syndrome in Buffalo/Mna rats. J Clin Invest. 2002;109:491-8 pubmed
  50. Nakanishi R, Onitsuka T, Shigematsu Y, Hashimoto M, Muranaka H, Yasumoto K. The immunomodulatory effect of cryopreservation in rat tracheal allotransplantation. J Heart Lung Transplant. 2002;21:890-8 pubmed
    ..Cryopreservation is one solution to the problem of donor organ deficit. To investigate the effect of cryopreservation on tracheal allografts, we performed 2 experiments in rats...
  51. Sun M, Alkon D. Open space swimming test to index antidepressant activity. J Neurosci Methods. 2003;126:35-40 pubmed
    ..Thus, this swimming test shows promising potential as a screen for novel antidepressants and, perhaps, for revealing some of the underlying pathophysiology of depression...
  52. Timm S, Otto C, Begrich D, Illert B, Hamelmann W, Ulrichs K, et al. Short-term immunosuppression after rat parathyroid allotransplantation. Microsurgery. 2003;23:503-7 pubmed
    ..Whether the combination of an additional graft pretreatment and immunosuppression has an impact on graft function will be further examined...
  53. Pieper G, Nilakantan V, Zhou X, Khanna A, Johnson C, Roza A, et al. Treatment with {alpha}-phenyl-N-tert-butylnitrone, a free radical-trapping agent, abrogates inflammatory cytokine gene expression during alloimmune activation in rat cardiac allografts. J Pharmacol Exp Ther. 2005;312:774-9 pubmed
    ..Thus, PBN retains significant anti-inflammatory properties through its action to down-regulate cytokine gene expression that contribute to protection against acute alloimmune activation in cardiac allografts...
  54. Liang Q, Elson A, Gerdes A. p38 MAP kinase activity is correlated with angiotensin II type 1 receptor blocker-induced left ventricular reverse remodeling in spontaneously hypertensive heart failure rats. J Card Fail. 2006;12:479-86 pubmed
    ..The present study was to determine if changes in mitogen-activated protein kinase (MAPK, including ERK, JNK, and p38) signaling correlate with ARB-elicited reversal of cardiac hypertrophy in SHHF rats...
  55. Buddhakala N, Talubmook C, Sriyotha P, Wray S, Kupittayanant S. Inhibitory effects of ginger oil on spontaneous and PGF2alpha-induced contraction of rat myometrium. Planta Med. 2008;74:385-91 pubmed publisher
    ..In conclusion, ginger oil is a potent inhibitor of phasic activity in rat uterus, irrespective of how it was produced. Our data suggest that the effects are largely due to citral, and could be via inhibition of L-type Ca channels...
  56. Woditschka S, Haag J, Sullivan R, Gould M. A short-term rat mammary carcinogenesis model for the prevention of hormonally responsive and nonresponsive in situ carcinomas. Cancer Prev Res (Phila). 2009;2:153-60 pubmed publisher
    ..Our prevention model represents a cost-efficient in vivo system to determine whether the preventive effects of a compound extend to hormonally nonresponsive mammary lesions, for which new chemoprevention approaches are needed...
  57. Song J, Ito T, Wei J, Huang M. [FTY720-induced lymphocyte apoptosis inhibits acute graft versus host disease in rat small bowel transplantation]. Zhonghua Wei Chang Wai Ke Za Zhi. 2010;13:60-3 pubmed
    ..To investigate the effect and mechanism of FTY720 on acute graft versus host disease (GVHD) in rat small bowel transplantation (SBTx)...
  58. Krishna A, al Rifai A, Hubner B, Rother P, Spanel Borowski K. Increase in calcitonin gene related peptide (CGRP) and decrease in mast cells in dihydroepiandrosterone (DHEA)-induced polycystic rat ovaries. Anat Embryol (Berl). 2001;203:375-82 pubmed
    ..05). Toluidine-blue-stained mast cells populated the medulla in both groups, yet had strikingly decreased in the DHEA treated ovaries (23.5 +/- 3.9 versus 89 +/- 5.6, P < 0.005)...
  59. Timm S, Hamelmann W, Otto C, Gassel A, Etzel M, Ulrichs K, et al. Influence of donor MHC class I antigen expression on graft survival after rat parathyroid allotransplantation. Langenbecks Arch Surg. 2001;386:430-3 pubmed
    ..We investigated the influence of donor MHC antigen expression on graft survival after parathyroid transplantation in three different strain combinations...
  60. Palm F, Liss P, Fasching A, Hansell P, Carlsson P. Transient glomerular hyperfiltration in the streptozotocin-diabetic Wistar Furth rat. Ups J Med Sci. 2001;106:175-82 pubmed
    ..We conclude that the transient increase in the GFR seen in the human disease, occurs in Wistar Furth rats, which is in contrast to a majority of other rat strains, where the GFR is persistently increased...
  61. Rodrigues L, Howe F, Griffiths J, Robinson S. Tumor R2* is a prognostic indicator of acute radiotherapeutic response in rodent tumors. J Magn Reson Imaging. 2004;19:482-8 pubmed
  62. Thomas T, Kuzman J, Anderson B, Andersen S, Schlenker E, Holder M, et al. Thyroid hormones induce unique and potentially beneficial changes in cardiac myocyte shape in hypertensive rats near heart failure. Am J Physiol Heart Circ Physiol. 2005;288:H2118-22 pubmed
    ..Based on our present understanding of ventricular remodeling and wall stress, we believe these changes are likely beneficial. Results suggest that TH may be an important regulator of myocyte transverse shape in heart disease...
  63. Hackstein H, Steinschulte C, Fiedel S, Eisele A, Rathke V, Stadlbauer T, et al. Sanglifehrin a blocks key dendritic cell functions in vivo and promotes long-term allograft survival together with low-dose CsA. Am J Transplant. 2007;7:789-98 pubmed
    ..We propose that SFA represents a novel class of immunophilin-binding immunosuppressants with high activity against DCs and the development of graft vasculopathy in CsA-treated recipients...
  64. Reuter S, Reiermann S, Wörner R, Schroter R, Edemir B, Buck F, et al. IF/TA-related metabolic changes--proteome analysis of rat renal allografts. Nephrol Dial Transplant. 2010;25:2492-501 pubmed publisher
    ..There is no effective therapy for IF/TA, in part due to the disease's multifactorial nature and its incompletely understood pathogenesis...
  65. Heaney A, Fernando M, Melmed S. Functional role of estrogen in pituitary tumor pathogenesis. J Clin Invest. 2002;109:277-83 pubmed
  66. Yuan X, Dong V, Coito A, Waaga A, Salama A, Benjamin C, et al. A novel CD154 monoclonal antibody in acute and chronic rat vascularized cardiac allograft rejection. Transplantation. 2002;73:1736-42 pubmed
    ..However, the role of the CD40-CD154 pathway in the development of chronic rejection and the effects of CD154 targeting on progression of chronic rejection have not been evaluated...
  67. Yuan X, Salama A, Dong V, Schmitt I, Najafian N, Chandraker A, et al. The role of the CD134-CD134 ligand costimulatory pathway in alloimmune responses in vivo. J Immunol. 2003;170:2949-55 pubmed
    ..Understanding the mechanisms of collaboration between these different pathways is important for the development of novel strategies to promote long-term allograft survival...
  68. McLennan S, Wang X, Moreno V, Yue D, Twigg S. Connective tissue growth factor mediates high glucose effects on matrix degradation through tissue inhibitor of matrix metalloproteinase type 1: implications for diabetic nephropathy. Endocrinology. 2004;145:5646-55 pubmed
  69. Witkowski P, Fawwaz R, Jin M, Depaz H, Oluwole O, Hardy M, et al. Effect of streptavidin on cardiac allograft prolongation is due to host T-Cell suppression. Transplant Proc. 2005;37:116-8 pubmed
    ..The aim of this study was to evaluate the effectiveness of streptavidin immunomodulation in the high-responder WF-to-Lewis combination...
  70. Størling J, Zaitsev S, Kapelioukh I, Karlsen A, Billestrup N, Berggren P, et al. Calcium has a permissive role in interleukin-1beta-induced c-jun N-terminal kinase activation in insulin-secreting cells. Endocrinology. 2005;146:3026-36 pubmed
    ..Our data suggest that Ca(2+) plays a permissive role in IL-1beta activation of the JNK signaling pathway in insulin-secreting cells...
  71. Liu D, Shen X, Fang Z, Gao F, Semiletova N, Cao M, et al. Identification of early tolerance regulator genes induced by allochimeric therapy using microarray-based genomewide scan. Transplant Proc. 2005;37:1942-3 pubmed
    ..Following array data normalization and modeling, we compared the above two treatment groups and identified a total of 250 tolerance regulator genes induced by allochimeric molecules only...
  72. Tuuminen R, Nykanen A, Keränen M, Krebs R, Alitalo K, Koskinen P, et al. The effect of platelet-derived growth factor ligands in rat cardiac allograft vasculopathy and fibrosis. Transplant Proc. 2006;38:3271-3 pubmed
    ..In this study, we evaluated the effects of PDGF ligands in chronic rejection...
  73. Kim S, Kong R, Popel A, Intaglietta M, Johnson P. Temporal and spatial variations of cell-free layer width in arterioles. Am J Physiol Heart Circ Physiol. 2007;293:H1526-35 pubmed
    ..The temporal variations increase as diameter increases and are inversely related on opposite sides of the vessel...
  74. French R, Broussard S, Meier W, Minshall C, Arkins S, Zachary J, et al. Age-associated loss of bone marrow hematopoietic cells is reversed by GH and accompanies thymic reconstitution. Endocrinology. 2002;143:690-9 pubmed
  75. Sitaru A, Timmermann W, Ulrichs K, Otto C. Hierarchical immunogenicity of donor MHC class I peptides in allotransplantation. Hum Immunol. 2002;63:871-9 pubmed
  76. Catterall F, King L, Clifford M, Ioannides C. Bioavailability of dietary doses of 3H-labelled tea antioxidants (+)-catechin and (-)-epicatechin in rat. Xenobiotica. 2003;33:743-53 pubmed
    ..6. It was established that the bioavailability of the tea antioxidants (+)-catechin and (-)-epicatechin in the rat following intake of dietary doses was poor...
  77. Eersels J, Klok R, Verbeek J, Jonker A, Herscheid J. Synthesis and evaluation of radiolabeled analogs of the antidepressant drug zimelidine as potential SPECT-ligands for the serotonin transporter. Nucl Med Biol. 2004;31:563-9 pubmed
    ..It may therefore be concluded that [(123)I]I-ZIM and [(123)I]I-nor-ZIM do not appear to be promising SPECT ligands for the SERT...
  78. Pinheiro A, Meireles G, de Barros Vieira A, Almeida D, Carvalho C, dos Santos J. Phototherapy improves healing of cutaneous wounds in nourished and undernourished Wistar rats. Braz Dent J. 2004;15 Spec No:SI21-8 pubmed
    ..The effect of the polarized light was more evident in nourished subjects and laser therapy more effective in the treatment of undernourished subjects, in both cases with a dose of 20J/cm2...
  79. Hessner M, Xiang B, Jia S, Geoffrey R, Holmes S, Meyer L, et al. Three-color cDNA microarrays with prehybridization quality control yield gene expression data comparable to that of commercial platforms. Physiol Genomics. 2006;25:166-78 pubmed
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    ..The BioBreeding rat is used as an animal model for the study of human Type 1 diabetes. In spite of a severe lymphopenia, these animals develop spontaneous diabetes at the age of 10-12 weeks...
  81. Jahr H, Hussmann B, Eckhardt T, Bretzel R. Successful single donor islet allotransplantation in the streptozotocin diabetes rat model. Cell Transplant. 2002;11:513-8 pubmed
  82. Tiefenbacher C, Kapitza J, Dietz V, Lee C, Niroomand F. Reduction of myocardial infarct size by fluvastatin. Am J Physiol Heart Circ Physiol. 2003;285:H59-64 pubmed
    ..We propose that the underlying mechanism is at least partially an inhibition of inflammation and endothelial dysfunction by preventing the activation and extravasation of neutrophils...
  83. Colson Y, Xu H, Huang Y, Ildstad S. Mixed xenogeneic chimerism induces donor-specific humoral and cellular immune tolerance for cardiac xenografts. J Immunol. 2004;173:5827-34 pubmed
  84. Horner B, Eberlin K, Ferguson K, Hirsh E, Randolph M, Butler P. Recipient damage after musculocutaneous transplant rejection. Transplantation. 2008;86:1104-10 pubmed publisher
    ..In the event of a composite allograft failure, damage to the recipient tissues may make retransplantation impossible. This study aimed to quantify the damage after composite allograft failure to assess whether retransplantation is feasible...
  85. Vlotides G, Cooper O, Chen Y, Ren S, Greenman Y, Melmed S. Heregulin regulates prolactinoma gene expression. Cancer Res. 2009;69:4209-16 pubmed publisher
    ..Targeted inhibition of up-regulated p185(c-neu)/ErbB3 activity could be useful for the treatment of aggressive prolactinomas resistant to conventional therapy...
  86. Edwin S, Joshi S, Jain D. Antifertility activity of leaves of Plumbago zeylanica Linn. in female albino rats. Eur J Contracept Reprod Health Care. 2009;14:233-9 pubmed publisher
    ..To evaluate the antifertility properties of extracts of leaves of Plumbago zeylanica Linn. (Plumbaginaceae)...
  87. Liang X, Adie S, John R, Boppart S. Dynamic spectral-domain optical coherence elastography for tissue characterization. Opt Express. 2010;18:14183-90 pubmed publisher
    ..With high resolution, high acquisition speed, and the ability to characterize the mechanical properties of tissue, this OCE technique has potential use in non-destructive volumetric imaging and clinical applications...
  88. Karlsen A, Rønn S, Lindberg K, Johannesen J, Galsgaard E, Pociot F, et al. Suppressor of cytokine signaling 3 (SOCS-3) protects beta -cells against interleukin-1beta - and interferon-gamma -mediated toxicity. Proc Natl Acad Sci U S A. 2001;98:12191-6 pubmed
  89. Gorantla V, Prabhune K, Perez Abadia G, Ildstad S, Maldonado C, Orhun H, et al. Composite tissue allotransplantation in chimeric hosts: part I. Prevention of graft-versus-host disease. Transplantation. 2003;75:922-32 pubmed
    ..The aim of this study was to develop an approach to study and prevent GVHD in a mixed chimeric-rat hind-limb transplantation model...
  90. Palm F, Carlsson P, Fasching A, Hellberg O, Nygren A, Hansell P, et al. Effects of the contrast medium iopromide on renal hemodynamics and oxygen tension in the diabetic rat kidney. Adv Exp Med Biol. 2003;530:653-9 pubmed
    ..We investigated the effects of the contrast medium (CM) iopromide on regional renal blood flow and oxygen tension (pO2) in the streptozotocin (STZ)-induced diabetic Wistar Furth rats...
  91. Prabhune K, Gorantla V, Perez Abadia G, Francois C, Vossen M, Laurentin Perez L, et al. Composite tissue allotransplantation in chimeric hosts part II. A clinically relevant protocol to induce tolerance in a rat model. Transplantation. 2003;76:1548-55 pubmed
    ..This study eliminates this delay period in a rat hind limb allotransplantation model by performing mixed allogeneic chimerism induction and transplantation "simultaneously."..
  92. Imanishi R, Ashizawa N, Ohtsuru A, Seto S, Akiyama Uchida Y, Kawano H, et al. GH suppresses TGF-beta-mediated fibrosis and retains cardiac diastolic function. Mol Cell Endocrinol. 2004;218:137-46 pubmed
    ..These results demonstrated that a chronic excess of GH have an anti-fibrotic effect on cardiac remodeling, probably through a down-regulation of TGF-beta signaling via de-phosphorylation of p38 MAPK...