inbred nzb mice

Summary

Summary: An inbred strain of mouse that is widely used as a model for AUTOIMMUNE DISEASES such as SYSTEMIC LUPUS ERYTHEMATOSUS.

Top Publications

  1. Waters S, Fu S, Gaskin F, Deshmukh U, Sung S, Kannapell C, et al. NZM2328: a new mouse model of systemic lupus erythematosus with unique genetic susceptibility loci. Clin Immunol. 2001;100:372-83 pubmed
    ..These results provide evidence for the importance of background genes on the expression of SLE, with implications for genetic studies of human SLE...
  2. Shui H, Ka S, Wu W, Lin Y, Hou Y, Su L, et al. LPS-evoked IL-18 expression in mesangial cells plays a role in accelerating lupus nephritis. Rheumatology (Oxford). 2007;46:1277-84 pubmed
    ..Second, it is also unclear whether LPS and/or IL-18 can induce MC apoptosis. Here, we attempted to clarify the cause-and-effect relationships between LPS stimulation, IL-18 production and MC apoptosis to address the above questions...
  3. Kikuchi S, Santiago Raber M, Amano H, Amano E, Fossati Jimack L, Moll T, et al. Contribution of NZB autoimmunity 2 to Y-linked autoimmune acceleration-induced monocytosis in association with murine systemic lupus. J Immunol. 2006;176:3240-7 pubmed
  4. Wang X, Huang W, Mihara M, Sinha J, Davidson A. Mechanism of action of combined short-term CTLA4Ig and anti-CD40 ligand in murine systemic lupus erythematosus. J Immunol. 2002;168:2046-53 pubmed
    ..These results suggest that the effect of costimulatory blockade in remission induction must be mediated by a different mechanism than is demonstrated in the disease prevention studies...
  5. Kang H, Michaels M, Berner B, Datta S. Very low-dose tolerance with nucleosomal peptides controls lupus and induces potent regulatory T cell subsets. J Immunol. 2005;174:3247-55 pubmed
  6. Zhang X, Smith D, Guth A, Wysocki L. A receptor presentation hypothesis for T cell help that recruits autoreactive B cells. J Immunol. 2001;166:1562-71 pubmed
  7. Kalled S, Cutler A, Burkly L. Apoptosis and altered dendritic cell homeostasis in lupus nephritis are limited by anti-CD154 treatment. J Immunol. 2001;167:1740-7 pubmed
    ..We suggest that these mechanisms comprise an autostimulatory loop, maintaining the cascade of autoimmunity by DC presentation of self-Ags derived from apoptotic cells and CD154-mediated costimulation...
  8. Schiffer L, Sinha J, Wang X, Huang W, von Gersdorff G, Schiffer M, et al. Short term administration of costimulatory blockade and cyclophosphamide induces remission of systemic lupus erythematosus nephritis in NZB/W F1 mice by a mechanism downstream of renal immune complex deposition. J Immunol. 2003;171:489-97 pubmed
    ..These findings suggest that costimulatory blockade together with cyclophosphamide influence the activation state of renal CD11c-positive cells and therefore lead to less B and T cell infiltration and nephritis...
  9. Ramos Barrón A, Piñera Haces C, Gomez Alamillo C, Santiuste Torcida I, Ruiz J, Buelta Carrillo L, et al. Prevention of murine lupus disease in (NZBxNZW)F1 mice by sirolimus treatment. Lupus. 2007;16:775-81 pubmed
    ..Our results demonstrate the beneficial effects of sirolimus in preventing the development of lupus disease in (NZBxNZW)F1 female mice...

More Information

Publications91

  1. Santiago Raber M, Laporte C, Reininger L, Izui S. Genetic basis of murine lupus. Autoimmun Rev. 2004;3:33-9 pubmed
    ..Obviously, further identification of the genetic defects present in lupus-prone mice is of paramount importance for understanding the immunopathogenesis of SLE...
  2. Rahman Z, Tin S, Buenaventura P, Ho C, Yap E, Yong R, et al. A novel susceptibility locus on chromosome 2 in the (New Zealand Black x New Zealand White)F1 hybrid mouse model of systemic lupus erythematosus. J Immunol. 2002;168:3042-9 pubmed
    ..Thus, multiple NZW alleles including the Wbw1 allele discovered in this study contribute to disease induction, in conjunction with the NZB genome, and the PL/J genome appears to be protective...
  3. Neubert K, Meister S, Moser K, Weisel F, Maseda D, Amann K, et al. The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis. Nat Med. 2008;14:748-55 pubmed publisher
    ..Hence, the elimination of autoreactive plasma cells by proteasome inhibitors might represent a new treatment strategy for antibody-mediated diseases...
  4. Singh R, Saxena V, Zang S, Li L, Finkelman F, Witte D, et al. Differential contribution of IL-4 and STAT6 vs STAT4 to the development of lupus nephritis. J Immunol. 2003;170:4818-25 pubmed
    ..Thus, STAT6 and IL-4 may selectively contribute to the development of glomerulosclerosis, whereas STAT4 may play a role in autoantibody production...
  5. Hahn B, Singh R, Wong W, Tsao B, Bulpitt K, Ebling F. Treatment with a consensus peptide based on amino acid sequences in autoantibodies prevents T cell activation by autoantigens and delays disease onset in murine lupus. Arthritis Rheum. 2001;44:432-41 pubmed
  6. Zhang L, Bertucci A, Smith K, Xu L, Datta S. Hyperexpression of cyclooxygenase 2 in the lupus immune system and effect of cyclooxygenase 2 inhibitor diet therapy in a murine model of systemic lupus erythematosus. Arthritis Rheum. 2007;56:4132-41 pubmed
  7. Rodriguez W, Mold C, Kataranovski M, Hutt J, Marnell L, Du Clos T. Reversal of ongoing proteinuria in autoimmune mice by treatment with C-reactive protein. Arthritis Rheum. 2005;52:642-50 pubmed
  8. Ramos M, Piñera C, Setién M, Buelta L, de Cos M, de Francisco A, et al. Modulation of autoantibody production by mycophenolate mofetil: effects on the development of SLE in (NZB x NZW)F1 mice. Nephrol Dial Transplant. 2003;18:878-83 pubmed
    ..In the present study, we evaluated mechanisms through which MMF may exert its therapeutic effect on the development of systemic autoimmunity...
  9. Kayagaki N, Yan M, Seshasayee D, Wang H, Lee W, French D, et al. BAFF/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-kappaB2. Immunity. 2002;17:515-24 pubmed
    ..When stabilized within a structured beta-hairpin peptide, six of these residues were sufficient to confer binding to BAFF...
  10. Lui S, Yung S, Tsang R, Zhang F, Chan K, Tam S, et al. Rapamycin prevents the development of nephritis in lupus-prone NZB/W F1 mice. Lupus. 2008;17:305-13 pubmed publisher
    ..We conclude that rapamycin is highly effective in preventing the development of nephritis in NZB/W F1 mice. The beneficial effects of rapamycin are mediated through inhibition of lymphoproliferation and reduced MCP-1 expression...
  11. Rozzo S, Allard J, Choubey D, Vyse T, Izui S, Peltz G, et al. Evidence for an interferon-inducible gene, Ifi202, in the susceptibility to systemic lupus. Immunity. 2001;15:435-43 pubmed
    ..These results, together with analyses of promoter region polymorphisms, strain distribution of expression, and effects on cell proliferation and apoptosis, implicate Ifi202 as a candidate gene for lupus...
  12. Cassese G, Lindenau S, De Boer B, Arce S, Hauser A, Riemekasten G, et al. Inflamed kidneys of NZB / W mice are a major site for the homeostasis of plasma cells. Eur J Immunol. 2001;31:2726-32 pubmed
    ..These experiments identify the inflamed kidneys of NZB / W mice as a site of prime relevance for the homeostasis of plasma cells, irrespective of their specificity...
  13. Suen J, Wu C, Chen Y, Wu W, Chiang B. Characterization of self-T-cell response and antigenic determinants of U1A protein with bone marrow-derived dendritic cells in NZB x NZW F1 mice. Immunology. 2001;103:301-9 pubmed
    ..The results presented here also indicate that it is feasible to use this approach to further explore strategies to design immunotherapy for patients with lupus...
  14. Bayona Bafaluy M, Blits B, Battersby B, Shoubridge E, Moraes C. Rapid directional shift of mitochondrial DNA heteroplasmy in animal tissues by a mitochondrially targeted restriction endonuclease. Proc Natl Acad Sci U S A. 2005;102:14392-7 pubmed
    ..This strategy could prevent disease onset or reverse clinical symptoms in patients harboring certain heteroplasmic pathogenic mutations in mtDNA...
  15. Matsuki N, Stanic A, Embers M, Van Kaer L, Morel L, Joyce S. Genetic dissection of V alpha 14J alpha 18 natural T cell number and function in autoimmune-prone mice. J Immunol. 2003;170:5429-37 pubmed
    ..The most notable of these map to the Idd4, Idd5, Idd9.1, and Idd13 regions of the mouse genome. Together these findings provide a clue to the genetic mechanism(s) underlying iNKT cell deficiency in NOD mice...
  16. Sawai C, Anderson K, WALSER KUNTZ D. Effect of bisphenol A on murine immune function: modulation of interferon-gamma, IgG2a, and disease symptoms in NZB X NZW F1 mice. Environ Health Perspect. 2003;111:1883-7 pubmed
    ..05). The long-lasting effects of BPA on IFN-gamma and IgG2a production likely contributed to the increased symptom-free period of the NZB/NZW mice...
  17. Bacman S, Williams S, Hernandez D, Moraes C. Modulating mtDNA heteroplasmy by mitochondria-targeted restriction endonucleases in a 'differential multiple cleavage-site' model. Gene Ther. 2007;14:1309-18 pubmed
  18. Alperovich G, Rama I, Lloberas N, Franquesa M, Poveda R, Goma M, et al. New immunosuppresor strategies in the treatment of murine lupus nephritis. Lupus. 2007;16:18-24 pubmed
    ..SRL produces great improvement in murine lupus nephritis, while FTY720 seems a promising alternative if used in appropriate doses...
  19. Ozmen L, Roman D, Fountoulakis M, Schmid G, Ryffel B, Garotta G. Experimental therapy of systemic lupus erythematosus: the treatment of NZB/W mice with mouse soluble interferon-gamma receptor inhibits the onset of glomerulonephritis. Eur J Immunol. 1995;25:6-12 pubmed
    ..These data suggest that an IFN-gamma inhibitor, such as the soluble IFN-gamma R, can be used for SLE therapy in the early stages of the disease...
  20. Chen S, Takeoka Y, Pike Nobile L, Ansari A, Boyd R, Gershwin M. Autoantibody production and cytokine profiles of MHC class I (beta2-microglobulin) gene deleted New Zealand black (NZB) mice. Clin Immunol Immunopathol. 1997;84:318-27 pubmed
    ..beta-/-2, and control C57BL/6 mice. Mitogen stimulated cells showed a decreased IFN-gamma, and a marked increase in IL-6 and IL-12 in NZB and NZB.beta2m-/- mice...
  21. Tillman D, Jou N, Hill R, Marion T. Both IgM and IgG anti-DNA antibodies are the products of clonally selective B cell stimulation in (NZB x NZW)F1 mice. J Exp Med. 1992;176:761-79 pubmed
    ..native DNA; and (d) the results provide a structural explanation for the selective development of IgG antibody to native DNA as autoimmunity to DNA progresses in (NZB x NZW)F1 mice...
  22. Haas C, Ryffel B, Le Hir M. IFN-gamma receptor deletion prevents autoantibody production and glomerulonephritis in lupus-prone (NZB x NZW)F1 mice. J Immunol. 1998;160:3713-8 pubmed
    ..Thus, the absence of glomerulonephritis in BWgammaR(-/-) mice is likely due to a dramatic yet unexplained effect of the inactivation of IFN-gamma signaling on autoAb production...
  23. Lightfoot J, Turner M, Daves M, Vordermark A, Kleeberger S. Genetic influence on daily wheel running activity level. Physiol Genomics. 2004;19:270-6 pubmed
    ..In conclusion, these data indicate that daily running wheel activity level in mice is significantly affected by genetic background and sex. ..
  24. Sharabi A, Haviv A, Zinger H, Dayan M, Mozes E. Amelioration of murine lupus by a peptide, based on the complementarity determining region-1 of an autoantibody as compared to dexamethasone: different effects on cytokines and apoptosis. Clin Immunol. 2006;119:146-55 pubmed
    ..Furthermore, down-regulation of FasL appeared to play a role in cytokine modulation. We conclude that specific treatment with hCDR1 ameliorates murine lupus via distinct mechanisms of action than those of dexamethasone. ..
  25. Ichii O, Kamikawa A, Otsuka S, Hashimoto Y, Sasaki N, Endoh D, et al. Overexpression of interferon-activated gene 202 (Ifi202) correlates with the progression of autoimmune glomerulonephritis associated with the MRL chromosome 1. Lupus. 2010;19:897-905 pubmed publisher
    ..MRLc1(82-100) kidneys. In conclusion, in the Ifi200 family, Ifi202 expressions in the kidney and immune organs significantly increased with GN progression...
  26. Stein O, Dabach Y, Ben Naim M, Halperin G, Stein Y. Effects of oleic acid and macrophage recruitment on cholesterol efflux in cell culture and in vivo. Nutr Metab Cardiovasc Dis. 2008;18:596-601 pubmed
    ..Our current findings, of retardation of cholesterol clearance from the depot in the presence of low macrophage recruitment, support the latter possibility. ..
  27. Mehrad B, Park S, Akangire G, Standiford T, Wu T, Zhu J, et al. The lupus-susceptibility locus, Sle3, mediates enhanced resistance to bacterial infections. J Immunol. 2006;176:3233-9 pubmed
    ..These observations support the concept that some of the genetic loci that mediate autoimmunity may also confer augmented antimicrobial innate immunity. ..
  28. Jiang Y, Hirose S, Sanokawa Akakura R, Abe M, Mi X, Li N, et al. Genetically determined aberrant down-regulation of FcgammaRIIB1 in germinal center B cells associated with hyper-IgG and IgG autoantibodies in murine systemic lupus erythematosus. Int Immunol. 1999;11:1685-91 pubmed
  29. Sakuma T, Ohtake M, Katsurayama Y, Jarukamjorn K, Nemoto N. Induction of CYP1A2 by phenobarbital in the livers of aryl hydrocarbon-responsive and -nonresponsive mice. Drug Metab Dispos. 1999;27:379-84 pubmed
    ..Cyclobarbital, pentobarbital, and secobarbital also induced CYP1A2 mRNA in primary culture hepatocytes from C57BL/6 mice. Barbital, in contrast, did not show any clear inductive effect on CYP1A2 mRNA. ..
  30. Stylianou I, Langley S, Walsh K, Chen Y, Revenu C, Paigen B. Differences in DBA/1J and DBA/2J reveal lipid QTL genes. J Lipid Res. 2008;49:2402-13 pubmed publisher
    ..We suggest that Tshr is the QTL gene for Chr 12 TG and HDL levels and that Ihh may account for the TG QTL on Chr 1. This cross highlights the advantage of crossing closely related strains for subsequent identification of QTL genes. ..
  31. Chen Y, Perry D, Boackle S, Sobel E, Molina H, Croker B, et al. Several genes contribute to the production of autoreactive B and T cells in the murine lupus susceptibility locus Sle1c. J Immunol. 2005;175:1080-9 pubmed
  32. Nakamura K, Nishimura H, Hirose S. Correlation of aggression with serum IgM level in autoimmune-prone NZB mice. Brain Res Dev Brain Res. 2005;159:145-8 pubmed
    ..The performance of aggressive behavior was correlated with serum IgM level. These results indicate that IgM class autoantibodies could be implicated in brain dysfunction without apparent pathological changes of autoimmune disease. ..
  33. Yamaguchi K, Inoue Y, Hisano M, Unten S, Shimamura T. Disease progression in the systemic lupus erythematosus model mouse (NZB/NZW F1) is inhibited by single shot estrogen treatment in the neonate. Lupus. 2003;12:332-4 pubmed
  34. Wu H, Ward F, Staines N. Histone peptide-induced nasal tolerance: suppression of murine lupus. J Immunol. 2002;169:1126-34 pubmed
    ..Finally, chronic nasal instillation of mice with the H471 peptide not only suppressed the development of autoantibodies, but also altered the severity of glomerulonephritis in lupus-prone SNF(1) mice. ..
  35. Scalapino K, Tang Q, Bluestone J, Bonyhadi M, Daikh D. Suppression of disease in New Zealand Black/New Zealand White lupus-prone mice by adoptive transfer of ex vivo expanded regulatory T cells. J Immunol. 2006;177:1451-9 pubmed
  36. Dabhi V, Hovik R, van Kaer L, Lindahl K. The alloreactive T cell response against the class Ib molecule H2-M3 is specific for high affinity peptides. J Immunol. 1998;161:5171-8 pubmed
    ..Long term lines and CTL clones reacted with only the high affinity peptides, demonstrating that alloreactive CTLs depend on specific peptides and that peptide affinity for class I correlates with alloantigenicity. ..
  37. Miller B, Schultz L, Long B, Pletcher M. Quantitative trait locus analysis identifies Gabra3 as a regulator of behavioral despair in mice. Mamm Genome. 2010;21:247-57 pubmed publisher
    ..This work suggests that GABRA3 regulates a behavioral endophenotype of depression and establishes this gene as a viable new target for the study and treatment of human depression. ..
  38. Cheung Y, Chang N, Cai Y, Bonventi G, MacLeod R, Wither J. Functional interplay between intrinsic B and T cell defects leads to amplification of autoimmune disease in New Zealand black chromosome 1 congenic mice. J Immunol. 2005;175:8154-64 pubmed
    ..Thus, T and B cell defects act in concert to produce and amplify the autoimmune phenotype...
  39. Tsurui H, Nishimura H, Hattori S, Hirose S, Okumura K, Shirai T. Seven-color fluorescence imaging of tissue samples based on Fourier spectroscopy and singular value decomposition. J Histochem Cytochem. 2000;48:653-62 pubmed
    ..Analyses of mouse thymic tissues stained with seven different fluorescent dyes provided clear independent images, and any combination of two or three individual dye images could be used for constructing multicolor images. ..
  40. Kang H, Ecklund D, Liu M, Datta S. Apigenin, a non-mutagenic dietary flavonoid, suppresses lupus by inhibiting autoantigen presentation for expansion of autoreactive Th1 and Th17 cells. Arthritis Res Ther. 2009;11:R59 pubmed publisher
    ..Because sustained immune activation and hyperexpression of COX-2 and c-FLIP contribute to lupus, we treated SNF1 mice that spontaneously develop human lupus-like disease with apigenin...
  41. Cooper G, Parks C. Occupational and environmental exposures as risk factors for systemic lupus erythematosus. Curr Rheumatol Rep. 2004;6:367-74 pubmed
    ..There are numerous avenues with respect to environmental factors in SLE that need additional research. ..
  42. Davis I, Zajac A, Nolte K, Botten J, Hjelle B, Matalon S. Elevated generation of reactive oxygen/nitrogen species in hantavirus cardiopulmonary syndrome. J Virol. 2002;76:8347-59 pubmed
  43. Beger E, Deocharan B, Edelman M, Erblich B, Gu Y, Putterman C. A peptide DNA surrogate accelerates autoimmune manifestations and nephritis in lupus-prone mice. J Immunol. 2002;168:3617-26 pubmed
    ..Based on the similarity between spontaneously arising anti-DNA Abs and several types of induced anti-DNA Abs, we suggest that there may be more than a single Ag that can trigger systemic lupus erythematosus. ..
  44. Yung S, Zhang Q, Zhang C, Chan K, Lui S, Chan T. Anti-DNA antibody induction of protein kinase C phosphorylation and fibronectin synthesis in human and murine lupus and the effect of mycophenolic acid. Arthritis Rheum. 2009;60:2071-82 pubmed publisher
    ..Human polyclonal anti-DNA antibodies induce TGFbeta1 and FN synthesis in human mesangial cells through PKC activation, which is inhibited by MPA. ..
  45. Thia K, Trapani J. The granzyme B gene is highly polymorphic in wild mice but essentially invariant in common inbred laboratory strains. Tissue Antigens. 2007;70:198-204 pubmed
    ..Unlike the protease, the extended granzyme B recognition and cleavage site in Bid, a key pro-apoptotic substrate, was invariant. ..
  46. Chinnery P. Modulating heteroplasmy. Trends Genet. 2002;18:173-6 pubmed
    ..Factors that modulate the mutation load are poorly understood, but recent work has started to unravel the mechanisms. In certain circumstances heteroplasmy might be regulated at the level of the individual mitochondrial genome. ..
  47. Raveche E, Salerno E, Scaglione B, Manohar V, Abbasi F, Lin Y, et al. Abnormal microRNA-16 locus with synteny to human 13q14 linked to CLL in NZB mice. Blood. 2007;109:5079-86 pubmed
    ..Linkage of the mir-15a/16-1 complex and the development of B-LPD in this spontaneous mouse model suggest that the altered expression of the mir-15a/16-1 is the molecular lesion in CLL. ..
  48. Palma B, Gabriel A, Colugnati F, Tufik S. Effects of sleep deprivation on the development of autoimmune disease in an experimental model of systemic lupus erythematosus. Am J Physiol Regul Integr Comp Physiol. 2006;291:R1527-32 pubmed
    ..However, no statistical difference was found in the other parameters analyzed. According to these results, sleep deprivation could be considered as a risk factor for the onset but not for the evolution of the disease. ..
  49. Fismen S, Hedberg A, Fenton K, Jacobsen S, Krarup E, Kamper A, et al. Circulating chromatin-anti-chromatin antibody complexes bind with high affinity to dermo-epidermal structures in murine and human lupus nephritis. Lupus. 2009;18:597-607 pubmed publisher
    ..Thus, chromatin-IgG complexes accounting for lupus nephritis seem to reach skin through circulation, but other undetermined factors are required for these complexes to deposit within skin membranes. ..
  50. Ramanujam M, Bethunaickan R, Huang W, Tao H, Madaio M, Davidson A. Selective blockade of BAFF for the prevention and treatment of systemic lupus erythematosus nephritis in NZM2410 mice. Arthritis Rheum. 2010;62:1457-68 pubmed publisher
    ..This shows that the inflammatory microenvironment may be a determinant of the outcome of B cell modulation strategies. ..
  51. Morel L, Wakeland E. Lessons from the NZM2410 model and related strains. Int Rev Immunol. 2000;19:423-46 pubmed
  52. Nakamura K, Xiu Y, Ohtsuji M, Sugita G, Abe M, Ohtsuji N, et al. Genetic dissection of anxiety in autoimmune disease. Hum Mol Genet. 2003;12:1079-86 pubmed
    ..Anxiety is shown to be mediated by multiple mediators. Our data suggest that a genetically determined endogenous excess amount of IFN-alpha in the brain may form one aspect of anxiety-like behavior seen in SLE-prone mice...
  53. Lively G, Koehn D, Hedberg Buenz A, Wang K, Anderson M. Quantitative trait loci associated with murine central corneal thickness. Physiol Genomics. 2010;42:281-6 pubmed publisher
    ..Future identification of the genes for these QTL will provide improved understanding of the processes regulating CCT and the pathophysiology of glaucoma...
  54. Marquina R, Díez M, Lopez Hoyos M, Buelta L, Kuroki A, Kikuchi S, et al. Inhibition of B cell death causes the development of an IgA nephropathy in (New Zealand white x C57BL/6)F(1)-bcl-2 transgenic mice. J Immunol. 2004;172:7177-85 pubmed
  55. Jiang B, Sun L, Hao S, Li X, Xu Y, Hou Y. Estrogen modulates bone marrow-derived DCs in SLE murine model-(NZB x NZW) F1 female mice. Immunol Invest. 2008;37:227-43 pubmed publisher
    ..The modulation is achieved by binding ER. The effects of E2 on DCs are different depending on the progression of SLE and cell differentiation status. This might be due to the difference of ER expression...
  56. Yung S, Cheung K, Zhang Q, Chan T. Anti-dsDNA antibodies bind to mesangial annexin II in lupus nephritis. J Am Soc Nephrol. 2010;21:1912-27 pubmed publisher
    ..This interaction provides a potential target for therapeutic intervention...
  57. Roy V, Bonventi G, Cai Y, MacLeod R, Wither J. Immune mechanisms leading to abnormal B cell selection and activation in New Zealand Black mice. Eur J Immunol. 2007;37:2645-56 pubmed
    ..Thus, polyclonal B cell activation in NZB mice does not require CD40 engagement, but results, in part, from dysregulated BCR-specific mechanisms...
  58. Seddiki N, Nato F, Lafaye P, Amoura Z, Piette J, Mazie J. Calreticulin, a potential cell surface receptor involved in cell penetration of anti-DNA antibodies. J Immunol. 2001;166:6423-9 pubmed
    ..Thus, the anti-DNA mAbs used in this study bound to CRT, suggesting that CRT may mediate their penetration into the cells and play an important role in lupus pathogenesis...
  59. Wright J, Alt J, Turner G, Krueger J. Differences in spatial learning comparing transgenic p75 knockout, New Zealand Black, C57BL/6, and Swiss Webster mice. Behav Brain Res. 2004;153:453-8 pubmed
    ..On the other hand, these results do not support the use of the NZB mouse as an animal model of human learning disability and dementia...
  60. Werwitzke S, Trick D, Sondermann P, Kamino K, Schlegelberger B, Kniesch K, et al. Treatment of lupus-prone NZB/NZW F1 mice with recombinant soluble Fc gamma receptor II (CD32). Ann Rheum Dis. 2008;67:154-61 pubmed
    ..Moreover, soluble Fc gamma Rs inhibit IC-caused Arthus reaction in vivo. Therefore, recombinant human soluble Fc gamma RII (CD32) was evaluated as a novel therapeutic strategy in lupus-like disease in NZB/NZW F(1) hybrids...
  61. Mary C, Laporte C, Parzy D, Santiago M, Stefani F, Lajaunias F, et al. Dysregulated expression of the Cd22 gene as a result of a short interspersed nucleotide element insertion in Cd22a lupus-prone mice. J Immunol. 2000;165:2987-96 pubmed
  62. Wellmann U, Werner A, Winkler T. Altered selection processes of B lymphocytes in autoimmune NZB/W mice, despite intact central tolerance against DNA. Eur J Immunol. 2001;31:2800-10 pubmed
    ..We propose different B cell receptor signaling thresholds for the NZB/W compared to C57BL/6 B cells. This could explain the quantitative differences in the B cell repertoire as well as the hyperactivity of B cells from NZB/W mice...
  63. Lui S, Tsang R, Chan K, Zhang F, Tam S, Yung S, et al. Rapamycin attenuates the severity of established nephritis in lupus-prone NZB/W F1 mice. Nephrol Dial Transplant. 2008;23:2768-76 pubmed publisher
    ..The aim of this study was to determine the effect of rapamycin on the severity of established nephritis in lupus-prone New Zealand Black/White F(1) (NZB/W F(1)) mice...
  64. Czarneski J, Lin Y, Chong S, McCarthy B, Fernandes H, Parker G, et al. Studies in NZB IL-10 knockout mice of the requirement of IL-10 for progression of B-cell lymphoma. Leukemia. 2004;18:597-606 pubmed
    ..These results indicate that IL-10 is a critical factor for the progression of this B-cell malignant disease...
  65. Dong L, Ito S, Ishii K, Klinman D. Suppressive oligodeoxynucleotides delay the onset of glomerulonephritis and prolong survival in lupus-prone NZB x NZW mice. Arthritis Rheum. 2005;52:651-8 pubmed
    ..We undertook this study to determine whether suppressive ODN alter the development of systemic autoimmunity, by evaluating their effect on the progression of lupus-like disease in NZB x NZW (NZB/NZW) mice...
  66. Spillmann F, Wabl M. Endogenous expression of activation-induced cytidine deaminase in cell line WEHI-231. J Immunol. 2004;173:1858-67 pubmed
    ..C to A. T base pairs to some extent. The cell line also expresses the germline transcripts of the Ig gamma 2b, epsilon, and alpha loci, but it does not switch its IgM surface Ig...
  67. Moriyama Y, Sekine C, Koyanagi A, Koyama N, Ogata H, Chiba S, et al. Delta-like 1 is essential for the maintenance of marginal zone B cells in normal mice but not in autoimmune mice. Int Immunol. 2008;20:763-73 pubmed publisher
  68. Wither J, Lajoie G, Heinrichs S, Cai Y, Chang N, Ciofani A, et al. Functional dissection of lupus susceptibility loci on the New Zealand black mouse chromosome 1: evidence for independent genetic loci affecting T and B cell activation. J Immunol. 2003;171:1697-706 pubmed
  69. Wang X, Feng J, Huang F, Fan Y, Wang Y, Cao L, et al. Effects of shikonin isolated from zicao on lupus nephritis in NZB/W F1 mice. Biol Pharm Bull. 2009;32:1565-70 pubmed
  70. Hirano T. Cytokines in autoimmune disease and chronic inflammatory proliferative disease. Cytokine Growth Factor Rev. 2002;13:297-8 pubmed
  71. Jiang Y, Ohtsuji M, Abe M, Li N, Xiu Y, Wen S, et al. Polymorphism and chromosomal mapping of the mouse gene for B-cell activating factor belonging to the tumor necrosis factor family (Baff) and association with the autoimmune phenotype. Immunogenetics. 2001;53:810-3 pubmed
  72. Lively G, Jiang B, Hedberg Buenz A, Chang B, Petersen G, Wang K, et al. Genetic dependence of central corneal thickness among inbred strains of mice. Invest Ophthalmol Vis Sci. 2010;51:160-71 pubmed publisher
    ..The purpose of this study was to test the strain dependence of CCT variability among inbred mice and identify cellular and molecular factors associated with differing CCT...
  73. Sogawa H, Kubo C. Influence of short-term repeated fasting on the longevity of female (NZB x NZW)F1 mice. Mech Ageing Dev. 2000;115:61-71 pubmed
    ..Mean survival times for fasting and control mice were 64.0+/-15.3 and 47.9+/-9.4 weeks, respectively. Short-term repeated fasting manipulation was also effective on the prolongation of life-span in autoimmune-prone mice...
  74. Grossman J, Tsao B. Genetics and systemic lupus erythematosus. Curr Rheumatol Rep. 2000;2:13-8 pubmed
    ..Studies to identify the genes in the susceptibility regions are underway. An understanding of the genes involved in the development of lupus should provide targets for more focused therapy...
  75. Moore K, de Waal Malefyt R, Coffman R, O GARRA A. Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol. 2001;19:683-765 pubmed
    ..This review highlights findings that have advanced our understanding of IL-10 and its receptor, as well as its in vivo function in health and disease...
  76. Michaels M, Kang H, Kaliyaperumal A, Satyaraj E, Shi Y, Datta S. A defect in deletion of nucleosome-specific autoimmune T cells in lupus-prone thymus: role of thymic dendritic cells. J Immunol. 2005;175:5857-65 pubmed
  77. Okada T, Lian Z, Hsu T, Naiki M, Ansari A, Robinson D, et al. Elevated C-met in thymic dendritic cells of New Zealand Black mice. Dev Immunol. 2002;9:29-34 pubmed
    ..Further studies involving such interactions are under way...
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