inbred mrl lpr mice

Summary

Summary: A mouse substrain that is genetically predisposed to the development of systemic lupus erythematosus-like syndrome, which has been found to be clinically similar to the human disease. It has been determined that this mouse strain carries a mutation in the fas gene. Also, the MRL/lpr is a useful model to study behavioral and cognitive deficits found in autoimmune diseases and the efficacy of immunosuppressive agents.

Top Publications

  1. Hasegawa H, Inoue A, Kohno M, Muraoka M, Miyazaki T, Terada M, et al. Antagonist of interferon-inducible protein 10/CXCL10 ameliorates the progression of autoimmune sialadenitis in MRL/lpr mice. Arthritis Rheum. 2006;54:1174-83 pubmed
    ..We undertook the present study to investigate the expression of chemokines during the development of autoimmune sialadenitis in MRL/lpr mice and the therapeutic effect of chemokine antagonists on sialadenitis...
  2. Brummel R, Roberts T, Stacey K, Lenert P. Higher-order CpG-DNA stimulation reveals distinct activation requirements for marginal zone and follicular B cells in lupus mice. Eur J Immunol. 2006;36:1951-62 pubmed
    ..A corollary is that the heightened responsiveness of lupus B cells to TLR9-induced stimulation cannot be ascribed to unprimed follicular B cells, but is rather mediated by hypersensitive marginal zone B cells...
  3. Shimizu S, Nakashima H, Masutani K, Inoue Y, Miyake K, Akahoshi M, et al. Anti-monocyte chemoattractant protein-1 gene therapy attenuates nephritis in MRL/lpr mice. Rheumatology (Oxford). 2004;43:1121-8 pubmed
    ..The aim of this study was to examine whether anti-MCP-1 gene therapy inhibits the progression of nephritis in MRL/lpr mice...
  4. Lin L, Peng S. Interleukin-18 receptor signaling is not required for autoantibody production and end-organ disease in murine lupus. Arthritis Rheum. 2005;52:984-6 pubmed
  5. Shimizu S, Sugiyama N, Masutani K, Sadanaga A, Miyazaki Y, Inoue Y, et al. Membranous glomerulonephritis development with Th2-type immune deviations in MRL/lpr mice deficient for IL-27 receptor (WSX-1). J Immunol. 2005;175:7185-92 pubmed
    ..Loss of WSX-1 thus favors Th2-type autoimmune responses, suggesting that the Th1/Th2 balance may be a pivotal determinant of human lupus nephritis development...
  6. Watson L, Moffatt Blue C, McDonald R, Kompfner E, Ait Azzouzene D, Nemazee D, et al. Paucity of V-D-D-J rearrangements and VH replacement events in lupus prone and nonautoimmune TdT-/- and TdT+/+ mice. J Immunol. 2006;177:1120-8 pubmed
  7. Christensen S, Shupe J, Nickerson K, Kashgarian M, Flavell R, Shlomchik M. Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus. Immunity. 2006;25:417-28 pubmed
    ..These findings reveal opposing inflammatory and regulatory roles for TLR7 and TLR9, despite similar tissue expression and signaling pathways. These results have important implications for TLR-directed therapy of autoimmune disease...
  8. Herlands R, Christensen S, Sweet R, Hershberg U, Shlomchik M. T cell-independent and toll-like receptor-dependent antigen-driven activation of autoreactive B cells. Immunity. 2008;29:249-60 pubmed publisher
    ..T cell-independent activation of certain autoreactive B cells, which gain stimuli via endogenous TLR ligands instead of T cells, may be the initial step in the generation of canonical autoantibodies...
  9. Monneaux F, Parietti V, Briand J, Muller S. Importance of spliceosomal RNP1 motif for intermolecular T-B cell spreading and tolerance restoration in lupus. Arthritis Res Ther. 2007;9:R111 pubmed
    ..The tolerogenic peptide P140, which is recognized by lupus patients' CD4+ T cells and known to protect MRL/lpr mice, is able to thwart emergence of intermolecular T-cell spreading in treated animals...

More Information

Publications83

  1. Wenderfer S, Soimo K, Wetsel R, Braun M. Analysis of C4 and the C4 binding protein in the MRL/lpr mouse. Arthritis Res Ther. 2007;9:R114 pubmed
    ..Given that immune complex renal injury in the MRL/lpr mouse is independent of Fc receptors as well as the major negative regulator of the classical pathway, new mechanisms for immune-complex-mediated renal injury need to be considered...
  2. Yang C, Tian L, Ling G, Trendell Smith N, Ma L, Lo C, et al. Immunological mechanisms and clinical implications of regulatory T cell deficiency in a systemic autoimmune disorder: roles of IL-2 versus IL-15. Eur J Immunol. 2008;38:1664-76 pubmed publisher
    ..These findings thus provide a clear causal relationship and immunological mechanism underlying Treg deficiency and systemic autoimmunity...
  3. Pawar R, Ramanjaneyulu A, Kulkarni O, Lech M, Segerer S, Anders H. Inhibition of Toll-like receptor-7 (TLR-7) or TLR-7 plus TLR-9 attenuates glomerulonephritis and lung injury in experimental lupus. J Am Soc Nephrol. 2007;18:1721-31 pubmed
    ..Hence, TLR-7 is proposed as a novel and potential therapeutic target in systemic lupus erythematosus...
  4. Liu J, Karypis G, Hippen K, Vegoe A, Ruiz P, Gilkeson G, et al. Genomic view of systemic autoimmunity in MRLlpr mice. Genes Immun. 2006;7:156-68 pubmed
    ..These data provide a unique genomic view of the progression to fatal autoimmunity in MRLlpr mice, and provide new candidate genes and pathways to explore...
  5. Wu X, Peng S. Toll-like receptor 9 signaling protects against murine lupus. Arthritis Rheum. 2006;54:336-42 pubmed
    ..This study was undertaken to determine the role of TLR-9 in the MRL/+ and MRL/lpr models of murine lupus...
  6. Lau C, Broughton C, Tabor A, Akira S, Flavell R, Mamula M, et al. RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement. J Exp Med. 2005;202:1171-7 pubmed
    ..As further evidence that TLRs play a key role in autoantibody responses in SLE, we found that autoimmune-prone mice, lacking the TLR adaptor protein MyD88, had markedly reduced chromatin, Sm, and rheumatoid factor autoantibody titers...
  7. Hasegawa H, Kohno M, Sasaki M, Inoue A, Ito M, Terada M, et al. Antagonist of monocyte chemoattractant protein 1 ameliorates the initiation and progression of lupus nephritis and renal vasculitis in MRL/lpr mice. Arthritis Rheum. 2003;48:2555-66 pubmed
    ..To examine whether chemokine antagonists inhibit the initiation and progression of lupus nephritis in MRL/lpr mice...
  8. Pellegrini M, Belz G, Bouillet P, Strasser A. Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim. Proc Natl Acad Sci U S A. 2003;100:14175-80 pubmed
    ..These findings have implications for the therapeutic manipulation of immune responses to infections and immunization...
  9. Lartigue A, Courville P, Auquit I, Francois A, Arnoult C, Tron F, et al. Role of TLR9 in anti-nucleosome and anti-DNA antibody production in lpr mutation-induced murine lupus. J Immunol. 2006;177:1349-54 pubmed
    ..These results indicate that in C57BL/6-lpr/lpr mice, TLR9 is absolutely required for the anti-nucleosome Ab response but not for anti-dsDNA Ab production which is involved in mesangial proliferation...
  10. Brummel R, Lenert P. Activation of marginal zone B cells from lupus mice with type A(D) CpG-oligodeoxynucleotides. J Immunol. 2005;174:2429-34 pubmed
    ..Through increased IL-10 secretion, MZ-B cells may also modify the activity of other cell types, particularly dendritic cells and macrophages...
  11. Neubert K, Meister S, Moser K, Weisel F, Maseda D, Amann K, et al. The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis. Nat Med. 2008;14:748-55 pubmed publisher
    ..Hence, the elimination of autoreactive plasma cells by proteasome inhibitors might represent a new treatment strategy for antibody-mediated diseases...
  12. Inoue A, Hasegawa H, Kohno M, Ito M, Terada M, Imai T, et al. Antagonist of fractalkine (CX3CL1) delays the initiation and ameliorates the progression of lupus nephritis in MRL/lpr mice. Arthritis Rheum. 2005;52:1522-33 pubmed
    ..Fractalkine (Fkn)/CX3CL1 and its receptor, CX3CR1, form one such chemokine system. We therefore undertook this study to investigate whether Fkn antagonist inhibits the initiation and progression of lupus nephritis in MRL/lpr mice...
  13. Hutcheson J, Scatizzi J, Siddiqui A, Haines G, Wu T, Li Q, et al. Combined deficiency of proapoptotic regulators Bim and Fas results in the early onset of systemic autoimmunity. Immunity. 2008;28:206-17 pubmed publisher
    ..These data demonstrate that dysregulation of the Bcl-2 or Fas pathways can alter the function of APCs, thereby leading to SLE pathogenesis...
  14. Santiago Raber M, Laporte C, Reininger L, Izui S. Genetic basis of murine lupus. Autoimmun Rev. 2004;3:33-9 pubmed
    ..Obviously, further identification of the genetic defects present in lupus-prone mice is of paramount importance for understanding the immunopathogenesis of SLE...
  15. Monneaux F, Parietti V, Briand J, Muller S. Intramolecular T cell spreading in unprimed MRL/lpr mice: importance of the U1-70k protein sequence 131-151. Arthritis Rheum. 2004;50:3232-8 pubmed
  16. Yang M, Suen J, Li S, Chiang B. Identification of T-cell epitopes on U1A protein in MRL/lpr mice: double-negative T cells are the major responsive cells. Immunology. 2005;115:279-86 pubmed
    ..The study here provides information on T-cell epitope analysis of the U1A antigen using BM-DCs as the effective antigen-presenting cells...
  17. Perez de Lema G, Maier H, Nieto E, Vielhauer V, Luckow B, Mampaso F, et al. Chemokine expression precedes inflammatory cell infiltration and chemokine receptor and cytokine expression during the initiation of murine lupus nephritis. J Am Soc Nephrol. 2001;12:1369-82 pubmed
    ..These results support the hypothesis that chemokines initiate leukocyte infiltration and precede proteinuria and renal damage in MRL/lpr mice...
  18. Mitchell D, Pickering M, Warren J, Fossati Jimack L, Cortes Hernandez J, Cook H, et al. C1q deficiency and autoimmunity: the effects of genetic background on disease expression. J Immunol. 2002;168:2538-43 pubmed
    ..The work also highlights the potential value of the C1q-deficient MRL/Mp(+/+) strain as a tool with which to dissect further the underlying mechanisms of the autoimmune syndrome associated with C1q deficiency...
  19. Ford M, Young K, Zhang Z, Ohashi P, Zhang L. The immune regulatory function of lymphoproliferative double negative T cells in vitro and in vivo. J Exp Med. 2002;196:261-7 pubmed
    ..These findings clearly demonstrate that B6/lpr DNTC have a potent immune regulatory function in vitro and in vivo. They also provide new insights into the mechanisms involved in the development of autoimmune disease in lpr mice...
  20. Monneaux F, Lozano J, Patarroyo M, Briand J, Muller S. T cell recognition and therapeutic effect of a phosphorylated synthetic peptide of the 70K snRNP protein administered in MR/lpr mice. Eur J Immunol. 2003;33:287-96 pubmed
    ..We further demonstrated that P140 is recognized by antibodies from lupus patients and binds to various HLA DR molecules, offering new hope for manipulating T cell response in humans...
  21. Yin Z, Bahtiyar G, Zhang N, Liu L, Zhu P, Robert M, et al. IL-10 regulates murine lupus. J Immunol. 2002;169:2148-55 pubmed
    ..In summary, our results provide evidence that IL-10 can down-modulate murine lupus through inhibition of pathogenic Th1 cytokine responses. Modulation of the level of IL-10 may be of potential therapeutic benefit for human lupus...
  22. Yasuda T, Yoshimoto T, Tsubura A, Matsuzawa A. Clear suppression of Th1 responses but marginal amelioration of autoimmune manifestations by IL-12p40 transgene in MRL-FAS(lprcg)/FAS(lprcg) mice. Cell Immunol. 2001;210:77-86 pubmed
    ..The results suggest that excess p40 production in vivo may suppress Th1 responses in autoantibody and IFN-gamma production but lead to minimal improvement of clinical manifestations of autoimmune disease in this mouse model...
  23. Monneaux F, Dumortier H, Steiner G, Briand J, Muller S. Murine models of systemic lupus erythematosus: B and T cell responses to spliceosomal ribonucleoproteins in MRL/Fas(lpr) and (NZB x NZW)F(1) lupus mice. Int Immunol. 2001;13:1155-63 pubmed
    ..This new finding can help to understand the mechanisms involved in the development of the anti-Sm/RNP antibody response and, particularly, the role played by non-MHC genes in this autoimmune response...
  24. Priatel J, Utting O, Teh H. TCR/self-antigen interactions drive double-negative T cell peripheral expansion and differentiation into suppressor cells. J Immunol. 2001;167:6188-94 pubmed
    ..Thus, the peripheral selection and maintenance of such autoreactive cells may serve to negatively regulate potential autoimmune T cell responses...
  25. Ito T, Seo N, Yagi H, Ohtani T, Tokura Y, Takigawa M, et al. Unique therapeutic effects of the Japanese-Chinese herbal medicine, Sairei-to, on Th1/Th2 cytokines balance of the autoimmunity of MRL/lpr mice. J Dermatol Sci. 2002;28:198-210 pubmed
    ..On the other hand, Th2 cell type immunoglobulins (IgG1) were suppressed. These results suggested that Sairei-to is potential for impairing shifted Th1/Th2 balance and hypergammaglobulinemia resulting in therapeutic effects...
  26. Kamogawa J, Terada M, Mizuki S, Nishihara M, Yamamoto H, Mori S, et al. Arthritis in MRL/lpr mice is under the control of multiple gene loci with an allelic combination derived from the original inbred strains. Arthritis Rheum. 2002;46:1067-74 pubmed
    ..To clarify the mode of inheritance and the genome origins of arthritis in a lupus-prone strain of mice, MRL/MpJ, bearing a Fas deletion mutant gene, lpr (MRL/lpr)...
  27. Reilly C, Gilkeson G. Use of genetic knockouts to modulate disease expression in a murine model of lupus, MRL/lpr mice. Immunol Res. 2002;25:143-53 pubmed
  28. Leadbetter E, Rifkin I, Marshak Rothstein A. Toll-like receptors and activation of autoreactive B cells. Curr Dir Autoimmun. 2003;6:105-22 pubmed
  29. Nose M, Nishihara M, Kamogawa J, Terada M, Nakatsuru S. Genetic basis of autoimmune disease in MRL/lpr mice: dissection of the complex pathological manifestations and their susceptibility loci. Rev Immunogenet. 2000;2:154-64 pubmed
    ..We conclude that the complex pathological manifestations of autoimmune disease are under the control of different combinations of polygenes...
  30. Matsumoto K, Watanabe N, Akikusa B, Kurasawa K, Matsumura R, Saito Y, et al. Fc receptor-independent development of autoimmune glomerulonephritis in lupus-prone MRL/lpr mice. Arthritis Rheum. 2003;48:486-94 pubmed
  31. Rodgers D, Pineda M, Suckling C, Harnett W, Harnett M. Drug-like analogues of the parasitic worm-derived immunomodulator ES-62 are therapeutic in the MRL/Lpr model of systemic lupus erythematosus. Lupus. 2015;24:1437-42 pubmed publisher
  32. Ahuja A, Shupe J, Dunn R, Kashgarian M, Kehry M, Shlomchik M. Depletion of B cells in murine lupus: efficacy and resistance. J Immunol. 2007;179:3351-61 pubmed
    ..Thus, whereas successful B cell depletion is a promising therapy for lupus, at least some patients might be resistant to the therapy as a byproduct of the autoimmune condition itself. ..
  33. Stock A, Wen J, Doerner J, Herlitz L, Gulinello M, Putterman C. Neuropsychiatric systemic lupus erythematosus persists despite attenuation of systemic disease in MRL/lpr mice. J Neuroinflammation. 2015;12:205 pubmed publisher
    ..Therefore, neuropsychiatric disease in the MRL/lpr lupus-prone strain of mice can occur absent any major contributions from systemic autoimmunity. ..
  34. Federzoni E, Gordon G, Muller S, Schmid I, Simon H, Yousefi S. Expression of CD95 on mature leukocytes of MRL/lpr mice after transplantation of genetically modified bone marrow stem cells. Immunol Lett. 2008;117:45-9 pubmed publisher
    ..This suggests that correction of CD95 deficiency can be achieved by gene therapy. ..
  35. Wang J, Mizui M, Zeng L, Bronson R, Finnell M, Terhorst C, et al. Inhibition of SHP2 ameliorates the pathogenesis of systemic lupus erythematosus. J Clin Invest. 2016;126:2077-92 pubmed publisher
    ..Taken together, these data identify SHP2 as a critical regulator of SLE pathogenesis and suggest targeting of its activity as a potent treatment for lupus patients. ..
  36. Wu X, McKenna M, Feng X, Nagy T, McDonald J. Osteoclast apoptosis: the role of Fas in vivo and in vitro. Endocrinology. 2003;144:5545-55 pubmed
  37. Rankin A, Guay H, Herber D, Bertino S, Duzanski T, Carrier Y, et al. IL-21 receptor is required for the systemic accumulation of activated B and T lymphocytes in MRL/MpJ-Fas(lpr/lpr)/J mice. J Immunol. 2012;188:1656-67 pubmed publisher
    ..Together, our data highlighted the novel observation that IL-21 is a critical regulator of multiple pathogenic B and T cell effector subsets in MRL(lpr) mice. ..
  38. Stanojcic M, Loheswaran G, Xu L, Hoffman S, Sakic B. Intrathecal antibodies and brain damage in autoimmune MRL mice. Brain Behav Immun. 2010;24:289-97 pubmed publisher
    ..Intrathecal BRA may be important in altering motivated responses and activity of major neuroendocrine axes at the onset of SLE-like disease. ..
  39. Liu Z, Xue L, Liu Z, Huang J, Wen J, Hu J, et al. Tumor Necrosis Factor-Like Weak Inducer of Apoptosis Accelerates the Progression of Renal Fibrosis in Lupus Nephritis by Activating SMAD and p38 MAPK in TGF-?1 Signaling Pathway. Mediators Inflamm. 2016;2016:8986451 pubmed publisher
    ..These findings suggest that TWEAK may contribute to chronic renal changes and renal fibrosis by activating TGF-?1 signaling pathway, and phosphorylation of Smad2 and p38 MAPK proteins was also involved in this signaling pathway. ..
  40. Rotolo J, Stancevic B, Lu S, Zhang J, Suh D, King C, et al. Cytolytic T cells induce ceramide-rich platforms in target cell membranes to initiate graft-versus-host disease. Blood. 2009;114:3693-706 pubmed publisher
    ..These studies indicate a requirement for target cell ASMase in evolution of GVHD in liver, small intestines, and skin and provide potential new targets for disease management. ..
  41. Wu X, Guo J, Ding R, Lv B, Bi L. CXCL13 blockade attenuates lupus nephritis of MRL/lpr mice. Acta Histochem. 2015;117:732-7 pubmed publisher
    ..Meanwhile, Th17/Treg ratio in spleens of MRL/lpr mice was significantly decreased by the blocking of CXCL13. These findings suggested that CXCL13 may be a promising target for the therapy of LN. ..
  42. Wang Y, Lu Y, Chai J, Sun M, Hu X, He W, et al. Y-27632, a Rho-associated protein kinase inhibitor, inhibits systemic lupus erythematosus. Biomed Pharmacother. 2017;88:359-366 pubmed publisher
    ..The findings showed that the inhibition of ROCK was beneficial for the prevention of systemic lupus erythematosus, which possibly by suppressing NF-?B activation. ..
  43. Qiu F, Li T, Zhang K, Wan J, Qi X. CD4(+)B220(+)TCR??(+) T cells produce IL-17 in lupus-prone MRL/lpr mice. Int Immunopharmacol. 2016;38:31-9 pubmed publisher
    ..Our findings suggest the pathogenic role of unusual CD4(+)B220(+) T cells in lupus disease in MRL/lpr mice according to their IL-17-producing ability and stimulatory function for conventional CD4(+)B220(-) T cells. ..
  44. Lalli P, Strainic M, Yang M, Lin F, Medof M, Heeger P. Locally produced C5a binds to T cell-expressed C5aR to enhance effector T-cell expansion by limiting antigen-induced apoptosis. Blood. 2008;112:1759-66 pubmed publisher
    ..The results show that C5aR signal transduction in T cells is important to allow optimal T-cell expansion, as well as to maintain naive cell viability, and does so by suppressing programmed cell death. ..
  45. Wang X, Gargalovic P, Wong J, Gu J, Wu X, Qi H, et al. Hyplip2, a new gene for combined hyperlipidemia and increased atherosclerosis. Arterioscler Thromb Vasc Biol. 2004;24:1928-34 pubmed
    ..Our data demonstrate that the Hyplip2 gene significantly contributes to combined hyperlipidemia and increased atherosclerosis in mice. ..
  46. Nishimura H, Yakeishi A, Saga T, Yamaki K. Effects of cevimeline on the immunolocalization of aquaporin-5 and the ultrastructure of salivary glands in Sjögren's syndrome model mice. Kurume Med J. 2009;56:39-47 pubmed
    ..Furthermore, cevimeline transiently normalized the localization of AQP-5 expression in the parotid and submandibular glands. ..
  47. Li B, Wang F, Schall N, Muller S. Rescue of autophagy and lysosome defects in salivary glands of MRL/lpr mice by a therapeutic phosphopeptide. J Autoimmun. 2018;90:132-145 pubmed publisher
    ..Our findings provide a proof-of-concept that targeting autophagy might represent a promising therapeutic strategy for treating patients with Sjögren's syndrome. ..
  48. Naviaux R, Le T, Bedelbaeva K, Leferovich J, Gourevitch D, Sachadyn P, et al. Retained features of embryonic metabolism in the adult MRL mouse. Mol Genet Metab. 2009;96:133-44 pubmed publisher
    ..The retention of embryonic features of metabolism in adulthood is rare in mammals. The MRL mouse provides a unique experimental window into the relationship between metabolism, stem cell biology, and regeneration. ..
  49. Liao R, Liu Q, Zheng Z, Fan J, Peng W, Kong Q, et al. Tacrolimus Protects Podocytes from Injury in Lupus Nephritis Partly by Stabilizing the Cytoskeleton and Inhibiting Podocyte Apoptosis. PLoS ONE. 2015;10:e0132724 pubmed publisher
    ..This study demonstrated that TAC reduced proteinuria and preserved renal function in LN through protecting podocytes from injury partly by stabilizing podocyte actin cytoskeleton and inhibiting podocyte apoptosis. ..
  50. Tchorbanov A, Voynova E, Mihaylova N, Todorov T, Nikolova M, Yomtova V, et al. Selective silencing of DNA-specific B lymphocytes delays lupus activity in MRL/lpr mice. Eur J Immunol. 2007;37:3587-96 pubmed
    ..The use of chimeric antibodies targeting inhibitory B lymphocyte receptors represents a novel approach for the selective suppression of autoreactive disease-associated B cells in autoimmune diseases. ..
  51. Ballok D, Sakic B. Purine receptor antagonist modulates serology and affective behaviors in lupus-prone mice: evidence of autoimmune-induced pain?. Brain Behav Immun. 2008;22:1208-16 pubmed publisher
    ..Hypercortisolemia may also initiate neuronal damage, and metabolic perturbations may underlie neuro-immuno-endocrine imbalances in MRL-lpr mice. ..
  52. Deng G, Liu L, Bahjat F, Pine P, Tsokos G. Suppression of skin and kidney disease by inhibition of spleen tyrosine kinase in lupus-prone mice. Arthritis Rheum. 2010;62:2086-92 pubmed publisher
  53. Tago F, Tsukimoto M, Nakatsukasa H, Kojima S. Repeated 0.5-Gy gamma irradiation attenuates autoimmune disease in MRL-lpr/lpr mice with suppression of CD3+CD4-CD8-B220+ T-cell proliferation and with up-regulation of CD4+CD25+Foxp3+ regulatory T cells. Radiat Res. 2008;169:59-66 pubmed
    ..We therefore conclude that repeated 0.5-Gy gamma irradiation suppresses the proliferation rate of CD3(+)CD4(-)CD8(-)B220(+) T cells and the production of IL6 and autoantibodies and up-regulates regulatory T cells...
  54. Toporkova L, Dubrovskaya V, Sakhno L, Tikhonova M, Chernykh E, Buneva V, et al. Hematopoietic progenitor colony formation in the immunopathogenesis of the autoimmune disorder in MRL/MpJ-lpr mice. Russ J Immunol. 2002;7:245-50 pubmed
  55. Forster N, Gallinat S, Jablonska J, Weiss S, Elsässer H, Lutz W. p300 protein acetyltransferase activity suppresses systemic lupus erythematosus-like autoimmune disease in mice. J Immunol. 2007;178:6941-8 pubmed
    ..These findings support the concept of treating lupus with inhibitors of protein deacetylases and point to B cells as a critical target of these drugs...
  56. Beare A, Metcalfe A, Ferguson M. Location of injury influences the mechanisms of both regeneration and repair within the MRL/MpJ mouse. J Anat. 2006;209:547-59 pubmed
  57. Steinmetz O, Turner J, Paust H, Lindner M, Peters A, Heiss K, et al. CXCR3 mediates renal Th1 and Th17 immune response in murine lupus nephritis. J Immunol. 2009;183:4693-704 pubmed publisher
    ..Our data therefore identify the chemokine receptor CXCR3 as a promising therapeutic target in lupus nephritis...
  58. Bone W, Walden C, Fritsch M, Voigtmann U, Leifke E, Gottwald U, et al. The sensitivity of murine spermiogenesis to miglustat is a quantitative trait: a pharmacogenetic study. Reprod Biol Endocrinol. 2007;5:1 pubmed
    ..To gain more insight into this species difference we have now evaluated the reproductive effects of miglustat in rabbits, in multiple mouse strains and in interstrain hybrid mice...
  59. Kawashima K, Fujii T. The lymphocytic cholinergic system and its biological function. Life Sci. 2003;72:2101-9 pubmed
    ..Taken together, these data present a compelling picture in which immune function is, at least in part, under the control of an independent non-neuronal lymphocytic cholinergic system...
  60. Dubrovskaya V, Andryushkova A, Kuznetsova I, Toporkova L, Buneva V, Orlovskaya I, et al. DNA-hydrolyzing antibodies from sera of autoimmune-prone MRL/MpJ-lpr mice. Biochemistry (Mosc). 2003;68:1081-8 pubmed
    ..The highest increase in proteinuria (25-fold), anti-DNA Abs titers (12-19-fold), and abzyme activity (120-fold) was found in mice after their immunization with DNA-protein complex...
  61. Zhang M, Mori S, Date F, Furukawa H, Ono M. A non-major histocompatibility locus determines tissue specificity in the pathogenic process underlying synovial proliferation in a mouse arthropathy model. Ann Rheum Dis. 2007;66:242-5 pubmed
    ..Here the coincidence of synovial proliferation and ankylosis in the descendent F(2) mice is reported...
  62. Nakatani K, Qu W, Zhang M, Fujii H, Furukawa H, Miyazaki T, et al. A genetic locus controlling aging-sensitive regression of B lymphopoiesis in an autoimmune-prone MRL/lpr strain of mice. Scand J Immunol. 2007;66:654-61 pubmed
    ..This is first evidence for the presence of a genetic locus that affects B lymphopoiesis in an aging-sensitive manner...
  63. Todd D, McHeyzer Williams L, Kowal C, Lee A, Volpe B, Diamond B, et al. XBP1 governs late events in plasma cell differentiation and is not required for antigen-specific memory B cell development. J Exp Med. 2009;206:2151-9 pubmed publisher
    ..Finally, we show that memory B cells develop normally in XBP1(CD19) mice, demonstrating that XBP1-mediated functions occur independently of any memory cell lineage commitment...
  64. Nishio H, Takase I, Fukunishi S, Takagi T, Tamura A, Miyazaki T, et al. Evidence for involvement of p59fyn in fasting-induced thymic involution. Scand J Immunol. 2005;62:103-7 pubmed
  65. Odegard J, DiPlacido L, Greenwald L, Kashgarian M, Kono D, Dong C, et al. ICOS controls effector function but not trafficking receptor expression of kidney-infiltrating effector T cells in murine lupus. J Immunol. 2009;182:4076-84 pubmed publisher
    ..Thus, while dispensable for acquisition of renal trafficking receptor expression, ICOS is strictly required for local inflammatory functions of autoreactive CD4 T cells in murine lupus...
  66. Dai Z, Nasr I, Reel M, Deng S, Diggs L, Larsen C, et al. Impaired recall of CD8 memory T cells in immunologically privileged tissue. J Immunol. 2005;174:1165-70 pubmed
    ..Therefore, memory T cells survey immunologically privileged tissues but are subject to the immunosuppressive mechanisms present at these sites...
  67. Xie C, Sharma R, Wang H, Zhou X, Mohan C. Strain distribution pattern of susceptibility to immune-mediated nephritis. J Immunol. 2004;172:5047-55 pubmed
    ..Detailed studies to dissect out the immunological and genetic basis of renal disease in these three strains are clearly warranted...
  68. Mori S, Tanda N, Ito M, Oishi H, Tsubaki T, Komori H, et al. Novel recombinant congenic mouse strain developing arthritis with enthesopathy. Pathol Int. 2008;58:407-14 pubmed publisher
    ..McH/lpr-RA1 mice may provide a new insight into the study of RA regarding the common genomic spectrum of seronegative RA and enthesopathy...
  69. Agrawal H, Jacob N, Carreras E, Bajana S, Putterman C, Turner S, et al. Deficiency of type I IFN receptor in lupus-prone New Zealand mixed 2328 mice decreases dendritic cell numbers and activation and protects from disease. J Immunol. 2009;183:6021-9 pubmed publisher
    ..Thus, IFNAR signaling significantly increases DC numbers, acquisition of Ag presentation competence, and proinflammatory function before onset of clinically apparent lupus disease...
  70. Sciascia S, Robson K, Zhu L, Garland M, Grabosch S, Kelamis J, et al. Immunization of nonautoimmune mice with DNA binding domains of the largest subunit of RNA polymerase I results in production of anti-dsDNA and anti-Sm/RNP antibodies. Autoimmunity. 2007;40:38-47 pubmed
    ..GST-P1 did not induce an anti-dsDNA response in these mice. These results demonstrate that RNAPI(S1)-NT, RNAPI(S1)-BD and La can participate in an anti-autoantigen/anti-DNA antibody loop during an SLE-like autoimmune response...
  71. Peairs A, Radjavi A, Davis S, Li L, Ahmed A, Giri S, et al. Activation of AMPK inhibits inflammation in MRL/lpr mouse mesangial cells. Clin Exp Immunol. 2009;156:542-51 pubmed publisher
    ..Taken together, these observations suggest that AICAR inhibits LPS/IFN-gamma-induced Akt phosphorylation through AMPK activation and may serve as a potential therapeutic target in inflammatory diseases...
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