inbred dahl rats

Summary

Summary: Inbred rats derived from Sprague-Dawley rats and used for the study of salt-dependent hypertension. Salt-sensitive and salt-resistant strains have been selectively bred to show the opposite genetically determined blood pressure responses to excess sodium chloride ingestion.

Top Publications

  1. Aoi W, Niisato N, Sawabe Y, Miyazaki H, Marunaka Y. Aldosterone-induced abnormal regulation of ENaC and SGK1 in Dahl salt-sensitive rat. Biochem Biophys Res Commun. 2006;341:376-81 pubmed
  2. Matsui H, Shimosawa T, Uetake Y, Wang H, Ogura S, Kaneko T, et al. Protective effect of potassium against the hypertensive cardiac dysfunction: association with reactive oxygen species reduction. Hypertension. 2006;48:225-31 pubmed
    ..Sufficient potassium supplementation might be an attractive strategy for cardiac protection, especially in the salt-sensitive hypertensive subjects...
  3. Nishikimi T, Akimoto K, Wang X, Mori Y, Tadokoro K, Ishikawa Y, et al. Fasudil, a Rho-kinase inhibitor, attenuates glomerulosclerosis in Dahl salt-sensitive rats. J Hypertens. 2004;22:1787-96 pubmed
    ..The present study was designed to clarify whether the Rho-Rho-kinase pathway is involved in the process of hypertensive glomerulosclerosis and to assess the therapeutic effect of fasudil, a specific Rho-kinase inhibitor...
  4. Mattson D, Dwinell M, Greene A, Kwitek A, Roman R, Jacob H, et al. Chromosome substitution reveals the genetic basis of Dahl salt-sensitive hypertension and renal disease. Am J Physiol Renal Physiol. 2008;295:F837-42 pubmed publisher
    ..Furthermore, this consomic rat panel provides a stable genetic platform that can facilitate further gene mapping by either linkage studies or the breeding of congenic and subcongenic rats...
  5. Maric C, Sandberg K, Hinojosa Laborde C. Glomerulosclerosis and tubulointerstitial fibrosis are attenuated with 17beta-estradiol in the aging Dahl salt sensitive rat. J Am Soc Nephrol. 2004;15:1546-56 pubmed
    ..3 +/- 2.1; OVX, 32.6 +/- 5.1; OVX+E(2), 24.3 +/- 2.4 mg/dl). The authors conclude that E(2) is renoprotective in the aging DSS rat by attenuating glomerulosclerosis and tubulointerstitial fibrosis...
  6. Fujii N, Nozawa T, Igawa A, Kato B, Igarashi N, Nonomura M, et al. Saturated glucose uptake capacity and impaired fatty acid oxidation in hypertensive hearts before development of heart failure. Am J Physiol Heart Circ Physiol. 2004;287:H760-6 pubmed
    ..These changes in both glucose and fatty acid metabolism that occur in association with myocardial hypertrophy may have a pathogenic role in the subsequent development of heart failure...
  7. Chen C, Hiura Y, Shen C, Iwai N. Assessment of mitochondrial DNA polymorphisms in salt-sensitive hypertension in Dahl salt-sensitive rats. Hypertens Res. 2008;31:107-15 pubmed publisher
    ..Intriguingly, the time course of body weight gain differed significantly between DL and LD F1 rats, suggesting the influence of mitochondrial polymorphisms on body composition...
  8. Saad Y, Garrett M, Manickavasagam E, Yerga Woolwine S, Farms P, Radecki T, et al. Fine-mapping and comprehensive transcript analysis reveals nonsynonymous variants within a novel 1.17 Mb blood pressure QTL region on rat chromosome 10. Genomics. 2007;89:343-53 pubmed
    ..Therefore, the present work defines a novel blood pressure QTL with three potential quantitative trait nucleotides...
  9. Ogihara T, Asano T, Fujita T. Contribution of salt intake to insulin resistance associated with hypertension. Life Sci. 2003;73:509-23 pubmed
    ..g., potassium supplementation and anti-oxidant administration--to the treatment of insulin resistance and hypertension...

More Information

Publications85

  1. Fujita M, Ando K, Nagae A, Fujita T. Sympathoexcitation by oxidative stress in the brain mediates arterial pressure elevation in salt-sensitive hypertension. Hypertension. 2007;50:360-7 pubmed
  2. Shehata M, Leenen F, Tesson F. Sequence analysis of coding and 3' and 5' flanking regions of the epithelial sodium channel alpha, beta, and gamma genes in Dahl S versus R rats. BMC Genet. 2007;8:35 pubmed
  3. Saad Y, Yerga Woolwine S, Saikumar J, Farms P, Manickavasagam E, Toland E, et al. Congenic interval mapping of RNO10 reveals a complex cluster of closely-linked genetic determinants of blood pressure. Hypertension. 2007;50:891-8 pubmed
    ..Because all of these genetic elements are located within a 1.06-Mb region of RNO10, our study has revealed a remarkable insight into a genomic module comprising very closely-linked, opposing genetic determinants of BP...
  4. Taylor N, Glocka P, Liang M, Cowley A. NADPH oxidase in the renal medulla causes oxidative stress and contributes to salt-sensitive hypertension in Dahl S rats. Hypertension. 2006;47:692-8 pubmed
    ..We conclude that excess renal medullary superoxide production in SS rats contributes to salt-induced hypertension, and NADPH oxidase is the major source of the excess superoxide...
  5. Gu J, Tian N, Shparago M, Tan W, Bailey A, Manning R. Renal NF-kappaB activation and TNF-alpha upregulation correlate with salt-sensitive hypertension in Dahl salt-sensitive rats. Am J Physiol Regul Integr Comp Physiol. 2006;291:R1817-24 pubmed
    ..These findings support the hypothesis that activation of NF-kappaB and upregulation of TNF-alpha are the important renal mechanisms linking proinflammatory response to SS hypertension...
  6. Van Vliet B, Chafe L, Halfyard S, Leonard A. Distinct rapid and slow phases of salt-induced hypertension in Dahl salt-sensitive rats. J Hypertens. 2006;24:1599-606 pubmed
    ..To test the hypothesis that Dahl salt-sensitive (Dahl-S) rats exhibit distinct and separable phases of salt sensitivity...
  7. Moreno C, Kaldunski M, Wang T, Roman R, Greene A, Lazar J, et al. Multiple blood pressure loci on rat chromosome 13 attenuate development of hypertension in the Dahl S hypertensive rat. Physiol Genomics. 2007;31:228-35 pubmed
    ..We conclude from these studies that there are four regions within chromosome 13 containing genes that interact epistatically and influence arterial pressure...
  8. Saad Y, Toland E, Yerga Woolwine S, Farms P, Joe B. Congenic mapping of a blood pressure QTL region on rat chromosome 10 using the Dahl salt-sensitive rat with introgressed alleles from the Milan normotensive strain. Mamm Genome. 2008;19:85-91 pubmed publisher
    ..LEW BP QTL region. Identification of the same QTL affecting BP in multiple rat strains will provide further support for the QTL's involvement and importance in human essential hypertension...
  9. Toland E, Saad Y, Yerga Woolwine S, Ummel S, Farms P, Ramdath R, et al. Closely linked non-additive blood pressure quantitative trait loci. Mamm Genome. 2008;19:209-18 pubmed publisher
    ..Overall, this study represents an intermediary yet obligatory progression towards the identification of genetic elements controlling BP...
  10. Shehata M. Genetic and dietary salt contributors to insulin resistance in Dahl salt-sensitive (S) rats. Cardiovasc Diabetol. 2008;7:7 pubmed publisher
  11. Toland E, Yerga Woolwine S, Farms P, Cicila G, Saad Y, Joe B. Blood pressure and proteinuria effects of multiple quantitative trait loci on rat chromosome 9 that differentiate the spontaneously hypertensive rat from the Dahl salt-sensitive rat. J Hypertens. 2008;26:2134-41 pubmed publisher
  12. Van Vliet B, Montani J. The time course of salt-induced hypertension, and why it matters. Int J Obes (Lond). 2008;32 Suppl 6:S35-47 pubmed publisher
  13. Cicila G, Morgan E, Lee S, Farms P, Yerga Woolwine S, Toland E, et al. Epistatic genetic determinants of blood pressure and mortality in a salt-sensitive hypertension model. Hypertension. 2009;53:725-32 pubmed publisher
    ..This is the first report of simultaneous detection of independent and epistatic loci dictating, in part, longevity in a hypertensive rat strain...
  14. Moreno C, Dumas P, Kaldunski M, Tonellato P, Greene A, Roman R, et al. Genomic map of cardiovascular phenotypes of hypertension in female Dahl S rats. Physiol Genomics. 2003;15:243-57 pubmed
    ..The development of a female rat systems biology map of cardiovascular function represents the first attempt to prioritize those regions of the genome important for development of hypertension and end organ damage in female rats...
  15. Manning R, Meng S, Tian N. Renal and vascular oxidative stress and salt-sensitivity of arterial pressure. Acta Physiol Scand. 2003;179:243-50 pubmed
    ..In conclusion, both human hypertension and experimental models of salt-sensitive hypertension have increased superoxide release, decreased antioxidant capacity and elevated renal damage...
  16. Shehata M. Important genetic checkpoints for insulin resistance in salt-sensitive (S) Dahl rats. Cardiovasc Diabetol. 2008;7:19 pubmed publisher
  17. Tian Z, Liu Y, Usa K, Mladinov D, Fang Y, Ding X, et al. Novel role of fumarate metabolism in dahl-salt sensitive hypertension. Hypertension. 2009;54:255-60 pubmed publisher
    ..These data suggest a novel role for fumarate metabolism in salt-induced hypertension and renal medullary oxidative stress...
  18. Farjah M, Roxas B, Geenen D, Danziger R. Dietary salt regulates renal SGK1 abundance: relevance to salt sensitivity in the Dahl rat. Hypertension. 2003;41:874-8 pubmed
  19. Sakata Y, Yamamoto K, Mano T, Nishikawa N, Yoshida J, Miwa T, et al. Temocapril prevents transition to diastolic heart failure in rats even if initiated after appearance of LV hypertrophy and diastolic dysfunction. Cardiovasc Res. 2003;57:757-65 pubmed
    ..The current study was designed to elucidate a therapeutic effect of ACE inhibitor, temocapril, administration initiated after LV hypertrophy (LVH) and diastolic dysfunction are evident...
  20. Sechi L. Mechanisms of insulin resistance in rat models of hypertension and their relationships with salt sensitivity. J Hypertens. 1999;17:1229-37 pubmed
  21. Ogihara T, Asano T, Ando K, Sakoda H, Anai M, Shojima N, et al. High-salt diet enhances insulin signaling and induces insulin resistance in Dahl salt-sensitive rats. Hypertension. 2002;40:83-9 pubmed
  22. Garrett M, Joe B, Dene H, Rapp J. Identification of blood pressure quantitative trait loci that differentiate two hypertensive strains. J Hypertens. 2002;20:2399-406 pubmed
    ..To describe genetic loci that differentiate blood pressures in two genetically hypertensive strains, the Dahl salt-sensitive (S) rat and the Albino Surgery (AS) rat...
  23. Leenen F, Ruzicka M, Huang B. The brain and salt-sensitive hypertension. Curr Hypertens Rep. 2002;4:129-35 pubmed
  24. Ying W, Sanders P. Cytochrome c mediates apoptosis in hypertensive nephrosclerosis in Dahl/Rapp rats. Kidney Int. 2001;59:662-72 pubmed
    ..The Dahl/Rapp salt-sensitive (S) rat is a model of low-renin hypertension, but these rats also develop renal lesions that are virtually identical to human hypertensive nephrosclerosis...
  25. Garrett M, Saad Y, Dene H, Rapp J. Blood pressure QTL that differentiate Dahl salt-sensitive and spontaneously hypertensive rats. Physiol Genomics. 2000;3:33-8 pubmed
    ..QTL for body weight on chr 4, 12, 18, and 20, each with an effect of about 30 g, were incidentally observed...
  26. Nagase M, Kaname S, Nagase T, Wang G, Ando K, Sawamura T, et al. Expression of LOX-1, an oxidized low-density lipoprotein receptor, in experimental hypertensive glomerulosclerosis. J Am Soc Nephrol. 2000;11:1826-36 pubmed
  27. Singh R, Mackraj I, Naidoo R, Gathiram P. Sanguinarine downregulates AT1a gene expression in a hypertensive rat model. J Cardiovasc Pharmacol. 2006;48:14-21 pubmed
    ..The action of losartan on increased urinary volume and decreased sodium excretion may be attributed to reduced vasopressin secretion. ..
  28. Aviv A, Hollenberg N, Weder A. Urinary potassium excretion and sodium sensitivity in blacks. Hypertension. 2004;43:707-13 pubmed
    ..In this sense, the biological implication of sodium sensitivity in blacks and in humans in general has ramifications above and beyond salt-evoked increase in blood pressure. ..
  29. Kunert M, Dwinell M, Drenjancevic Peric I, Lombard J. Sex-specific differences in chromosome-dependent regulation of vascular reactivity in female consomic rat strains from a SSxBN cross. Am J Physiol Regul Integr Comp Physiol. 2008;295:R516-27 pubmed publisher
    ..Our findings are the first to link physiological traits with specific chromosomes in female SS rats and support the idea that sex is an important environmental variable that plays a role in the expression and regulation of genes. ..
  30. Tian N, Moore R, Braddy S, Rose R, Gu J, Hughson M, et al. Interactions between oxidative stress and inflammation in salt-sensitive hypertension. Am J Physiol Heart Circ Physiol. 2007;293:H3388-95 pubmed
    ..In conclusion, antioxidant treatment of high-Na Dahl S rats decreased renal inflammatory cytokines and chemokines, renal immune cells, NF-kappaB, and arterial pressure and improved renal function and damage. ..
  31. Wiessner J, Garrett M, Roman R, Mandel N. Dissecting the genetic basis of kidney tubule response to hyperoxaluria using chromosome substitution strains. Am J Physiol Renal Physiol. 2009;297:F301-6 pubmed publisher
    ..These observations establish that BN rat chromosome 2 and 18 harbor genes that contribute to these processes...
  32. Fujii S, Zhang L, Igarashi J, Kosaka H. L-arginine reverses p47phox and gp91phox expression induced by high salt in Dahl rats. Hypertension. 2003;42:1014-20 pubmed
  33. Kido M, Ando K, Onozato M, Tojo A, Yoshikawa M, Ogita T, et al. Protective effect of dietary potassium against vascular injury in salt-sensitive hypertension. Hypertension. 2008;51:225-31 pubmed
  34. Thierry Palmer M, Cephas S. Plasma 25-hydroxycholecalciferol and 1,25-dihydroxycholecalciferol concentrations are decreased in hind limb unloaded Dahl salt-sensitive female rats. J Steroid Biochem Mol Biol. 2010;118:188-93 pubmed publisher
  35. Katsuragi N, Morishita R, Nakamura N, Ochiai T, Taniyama Y, Hasegawa Y, et al. Periostin as a novel factor responsible for ventricular dilation. Circulation. 2004;110:1806-13 pubmed
    ..The present study demonstrates the contribution of the periostin gene to cardiac dilation in animal models. Inhibition of periostin might become a new therapeutic target for the treatment of heart failure. ..
  36. Siu P, Bae S, Bodyak N, Rigor D, Kang P. Response of caspase-independent apoptotic factors to high salt diet-induced heart failure. J Mol Cell Cardiol. 2007;42:678-86 pubmed
    ..These findings are consistent with the hypothesis that caspase-independent events are involved in cardiac apoptosis during the late remodeling stage of pathologic heart failure. ..
  37. Meng S, Cason G, Gannon A, Racusen L, Manning R. Oxidative stress in Dahl salt-sensitive hypertension. Hypertension. 2003;41:1346-52 pubmed
    ..The data suggest that oxidative stress contributes to Dahl salt-sensitive hypertension and the accompanying renal damage. ..
  38. Hasegawa H, Yamamoto R, Takano H, Mizukami M, Asakawa M, Nagai T, et al. 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors prevent the development of cardiac hypertrophy and heart failure in rats. J Mol Cell Cardiol. 2003;35:953-60 pubmed
    ..These results suggest that statins have a protective effect on cardiac myocytes and may be useful to prevent the development of hypertensive heart failure. ..
  39. Kayama Y, Minamino T, Toko H, Sakamoto M, Shimizu I, Takahashi H, et al. Cardiac 12/15 lipoxygenase-induced inflammation is involved in heart failure. J Exp Med. 2009;206:1565-74 pubmed publisher
    ..Our results suggest that cardiac 12/15-LOX is involved in the development of heart failure and that inhibition of 12/15-LOX could be a novel treatment for this condition. ..
  40. Hoagland K, Flasch A, Dahly Vernon A, dos Santos E, Knepper M, Roman R. Elevated BSC-1 and ROMK expression in Dahl salt-sensitive rat kidneys. Hypertension. 2004;43:860-5 pubmed
    ..These results suggest that overexpression of ROMK and BSC-1 in the thick ascending limb combined with a deficiency in renal formation of 20-HETE may predispose Dahl S rats fed a high-salt diet to Na+ retention and hypertension. ..
  41. Thierry Palmer M, Cephas S, Muttardy F, Al Mahmoud A. High dietary cholecalciferol increases plasma 25-hydroxycholecalciferol concentration, but does not attenuate the hypertension of Dahl salt-sensitive rats fed a high salt diet. J Steroid Biochem Mol Biol. 2008;111:7-12 pubmed publisher
    ..Low salt intake may be necessary to both maintain optimal vitamin D status and prevent hypertension in salt-sensitive individuals. ..
  42. Rodenbaugh D, Wang W, Davis J, Edwards T, Potter J, Metzger J. Parvalbumin isoforms differentially accelerate cardiac myocyte relaxation kinetics in an animal model of diastolic dysfunction. Am J Physiol Heart Circ Physiol. 2007;293:H1705-13 pubmed
    ..This comparative analysis showing distinct functional outcomes raises the prospect of utilizing naturally occurring Parv variants to address disease-associated slowed cardiac relaxation. ..
  43. Dai Q, Lin J, Craig T, Chou Y, Hinojosa Laborde C, Lindsey M. Estrogen effects on MMP-13 and MMP-14 regulation of left ventricular mass in Dahl salt-induced hypertension. Gend Med. 2008;5:74-85 pubmed
    ..Estrogen loss or gain resulted in a shift in MMP profiles, suggesting that MMP-13 and MMP-14 may be differentially regulated in postmenopausal hypertension. ..
  44. Satoh M, Haruna Y, Fujimoto S, Sasaki T, Kashihara N. Telmisartan improves endothelial dysfunction and renal autoregulation in Dahl salt-sensitive rats. Hypertens Res. 2010;33:135-42 pubmed publisher
    ..Endothelial dysfunction in the glomeruli and impaired renal autoregulation, which may cause glomerular sclerosis, were observed in DS rat kidney. Telmisartan treatment improves these dysfunctions in hypertensive renal disease. ..
  45. Zheng W, Ji H, Maric C, Wu X, Sandberg K. Effect of dietary sodium on estrogen regulation of blood pressure in Dahl salt-sensitive rats. Am J Physiol Heart Circ Physiol. 2008;294:H1508-13 pubmed publisher
    ..These findings have implications for women with salt-sensitive hypertension and women who are E(2) deficient, such as postmenopausal women. ..
  46. Mattson D, James L, Berdan E, Meister C. Immune suppression attenuates hypertension and renal disease in the Dahl salt-sensitive rat. Hypertension. 2006;48:149-56 pubmed
    ..These experiments indicate that the activation of the immune system or renal infiltration of immune cells plays an important role in the development of hypertension and renal disease in Dahl SS/Mcw rats consuming an elevated NaCl diet. ..
  47. Cheng X, Obata K, Kuzuya M, Izawa H, Nakamura K, Asai E, et al. Elastolytic cathepsin induction/activation system exists in myocardium and is upregulated in hypertensive heart failure. Hypertension. 2006;48:979-87 pubmed
    ..These results suggest that cathepsin S participates in pathological LV remodeling associated with hypertension-induced HF. This protease is, thus, a potential target for therapeutics aimed at preventing or reversing cardiac remodeling. ..
  48. Nagase M, Shibata S, Yoshida S, Nagase T, Gotoda T, Fujita T. Podocyte injury underlies the glomerulopathy of Dahl salt-hypertensive rats and is reversed by aldosterone blocker. Hypertension. 2006;47:1084-93 pubmed
  49. Chen Q, Nishida Y, Zhou M, Murakami H, Morita H, Hosomi H, et al. Organ and development related difference in tissue norepinephrine concentrations in Dahl rats. J Auton Nerv Syst. 1998;71:175-82 pubmed
    ..These tNE behaviors in S rats may not be related to blood pressure or baroreflex sensitivity, but might be involved in an abnormal sympathetic nerve activity...
  50. Ichihara S, Obata K, Yamada Y, Nagata K, Noda A, Ichihara G, et al. Attenuation of cardiac dysfunction by a PPAR-alpha agonist is associated with down-regulation of redox-regulated transcription factors. J Mol Cell Cardiol. 2006;41:318-29 pubmed
    ..These effects were associated with inhibition of the inflammatory response and of activation of redox-regulated transcription factors in the left ventricle...
  51. Lee S, Liu J, Qi N, Guarnera R, Lee S, Cicila G. Use of a panel of congenic strains to evaluate differentially expressed genes as candidate genes for blood pressure quantitative trait loci. Hypertens Res. 2003;26:75-87 pubmed
    ..This data suggests that Hao2 should be examined as a candidate gene for the rat chromosome 2 (RNO2) BP QTL...
  52. Horie T, Ono K, Nishi H, Iwanaga Y, Nagao K, Kinoshita M, et al. MicroRNA-133 regulates the expression of GLUT4 by targeting KLF15 and is involved in metabolic control in cardiac myocytes. Biochem Biophys Res Commun. 2009;389:315-20 pubmed publisher
    ..The present results indicated that miR-133 regulates the expression of GLUT4 by targeting KLF15 and is involved in metabolic control in cardiomyocytes...
  53. Zhou M, Schulman I, Raij L. Role of angiotensin II and oxidative stress in vascular insulin resistance linked to hypertension. Am J Physiol Heart Circ Physiol. 2009;296:H833-9 pubmed publisher
  54. Kajimoto K, Hiura Y, Sumiya T, Yasui N, Okuda T, Iwai N. Exclusion of the catechol-o-methyltransferase gene from genes contributing to salt-sensitive hypertension in dahl salt-sensitive rats. Hypertens Res. 2007;30:459-67 pubmed
    ..Thus, Comt was excluded from the candidate genes contributing to salt-sensitive hypertension in DS rats. A true gene responsible for pulse pressure in this chromosome 11 region remains to be determined...
  55. Zhou M, Schulman I, Jaimes E, Raij L. Thiazide diuretics, endothelial function, and vascular oxidative stress. J Hypertens. 2008;26:494-500 pubmed publisher
  56. Kawarazaki H, Ando K, Nagae A, Fujita M, Matsui H, Fujita T. Mineralocorticoid receptor activation contributes to salt-induced hypertension and renal injury in prepubertal Dahl salt-sensitive rats. Nephrol Dial Transplant. 2010;25:2879-89 pubmed publisher
    ..Excessive prepubertal salt intake permanently increases blood pressure (BP). We examined the role that the mineralocorticoid receptor (MR) plays in the salt-induced hypertension and renal damage of prepubertal Dahl salt-sensitive (SS) rats...
  57. Matsuda H, Fukuda N, Ueno T, Tahira Y, Ayame H, Zhang W, et al. Development of gene silencing pyrrole-imidazole polyamide targeting the TGF-beta1 promoter for treatment of progressive renal diseases. J Am Soc Nephrol. 2006;17:422-32 pubmed
    ..These results indicate that Py-Im polyamide that targets TGF-beta1 will be a novel gene-silencing agent for the TGF-beta1-associated diseases, including progressive renal diseases...
  58. Sharp J, Azar T, Lawson D. Effects of a cage enrichment program on heart rate, blood pressure, and activity of male sprague-dawley and spontaneously hypertensive rats monitored by radiotelemetry. Contemp Top Lab Anim Sci. 2005;44:32-40 pubmed
    ..Whether this enrichment program should be used in an animal facility depends on several factors, particularly the professional judgment of the research, veterinary, and animal care staffs involved...
  59. Bolten C, Payne M, McDonald W, Blanner P, Chott R, Ghosh S, et al. Thiazolidinediones inhibit the progression of established hypertension in the Dahl salt-sensitive rat. Diab Vasc Dis Res. 2007;4:117-23 pubmed
    ..These data suggest that it may be possible to find insulin-sensitising agents that have beneficial cardiovascular pharmacology with broad applications for disease prevention...
  60. Forde P, Scribner A, Dial R, Loscalzo J, Trolliet M. Prevention of hypertension and renal dysfunction in Dahl rats by alpha-tocopherol. J Cardiovasc Pharmacol. 2003;42:82-8 pubmed
  61. Kaneda R, Takada S, Yamashita Y, Choi Y, Nonaka Sarukawa M, Soda M, et al. Genome-wide histone methylation profile for heart failure. Genes Cells. 2009;14:69-77 pubmed publisher
    ..However, K9TM mark-profile was less dependent on the disease status compared to that of K4TM. Our data collectively reveal global epigenetic changes in cardiac myocytes associated with heart failure...
  62. Bonacasa B, Sanchez M, Rodriguez F, Lopez B, Quesada T, Fenoy F, et al. 2-Methoxyestradiol attenuates hypertension and coronary vascular remodeling in spontaneously hypertensive rats. Maturitas. 2008;61:310-6 pubmed publisher
    ..We investigated the effect of 2-methoxyestradiol (an active metabolite of estradiol with non-feminizing activity) on the development of hypertension and myocardial vascular remodeling in male and female ovarectomized SHR...
  63. Deng A, Ménard A, Xiao C, Roy J. Sexual dimorphism on hypertension of quantitative trait loci entrapped in Dahl congenic rats. Clin Exp Hypertens. 2008;30:511-9 pubmed publisher
    ..Men and women may possess distinctive as well as shared genetic determinants for SAP, DAP, and MAP. The data on a single gene or marker might be pooled from both genders only when evidence favors the sex-independence in a study...
  64. Horinaka S, Kobayashi N, Mori Y, Yagi H, Onoda M, Matsuoka H. Expression of inducible nitric oxide synthase, left ventricular function and remodeling in Dahl salt-sensitive hypertensive rats. Int J Cardiol. 2003;91:25-35 pubmed
    ..Our aim was to examine whether inducible nitric oxide synthase (iNOS) expression in the left ventricle (LV) is associated with deterioration of contractility of the failing heart...
  65. Mazancova K, Kopecky M, Miksik I, Pacha J. 11beta-Hydroxysteroid dehydrogenase in the heart of normotensive and hypertensive rats. J Steroid Biochem Mol Biol. 2005;94:273-7 pubmed
    ..These results show that the heart is able to metabolize glucocorticoids and that this metabolism is strain-dependent but do not support the notion of association between cardiac hypertrophy and changes of 11HSD1 and 11HSD2 expression...
  66. Zhu A, Yoneda T, Demura M, Karashima S, Usukura M, Yamagishi M, et al. Effect of mineralocorticoid receptor blockade on the renal renin-angiotensin system in Dahl salt-sensitive hypertensive rats. J Hypertens. 2009;27:800-5 pubmed publisher
    ..However, the effect of blockade of mineralocorticoid receptor on the renal (pro)renin receptor, angiotensinogen, ACE and AT1R in Dahl salt-sensitive rats is unknown...
  67. Zhou M, Schulman I, Raij L. Vascular inflammation, insulin resistance, and endothelial dysfunction in salt-sensitive hypertension: role of nuclear factor kappa B activation. J Hypertens. 2010;28:527-35 pubmed publisher
    ..Herein, we investigated whether activation of NF kappaB contributes to the development of endothelial dysfunction, vascular injury, and vascular and peripheral insulin resistance in salt-sensitive hypertension...
  68. Hermann M, Shaw S, Kiss E, Camici G, Bühler N, Chenevard R, et al. Selective COX-2 inhibitors and renal injury in salt-sensitive hypertension. Hypertension. 2005;45:193-7 pubmed
    ..0015 versus DS-placebo). This head-to-head comparison of selective and nonselective COX inhibitors demonstrates differential effects of coxibs on renal morphology and function in salt-dependent hypertension...
  69. Kiya Y, Miura S, Fujino M, Imaizumi S, Karnik S, Saku K. Clinical and pharmacotherapeutic relevance of the double-chain domain of the angiotensin II type 1 receptor blocker olmesartan. Clin Exp Hypertens. 2010;32:129-36 pubmed publisher
    ..In Study 2, the depressor effect of olmesartan was significantly stronger than those of other ARBs, which do not contain the DCD. These additive effects by olmesartan may be due to DCD...
  70. Bagrov A, Agalakova N, Kashkin V, Fedorova O. Endogenous cardiotonic steroids and differential patterns of sodium pump inhibition in NaCl-loaded salt-sensitive and normotensive rats. Am J Hypertens. 2009;22:559-63 pubmed publisher
    ..We hypothesized that in NaCl-loaded DS and normotensive Sprague-Dawley rats (S-D), MBG would elicit different patterns of sodium pump inhibition...
  71. Louhelainen M, Vahtola E, Kaheinen P, Leskinen H, Merasto S, Kytö V, et al. Effects of levosimendan on cardiac remodeling and cardiomyocyte apoptosis in hypertensive Dahl/Rapp rats. Br J Pharmacol. 2007;150:851-61 pubmed
    ..This study was conducted to study whether treatment with a novel inotropic vasodilator compound, levosimendan, could prevent hypertension-induced cardiac remodeling and cardiomyocyte apoptosis...
  72. Ojewole J, Adewole S, Olayiwola G. Hypoglycaemic and hypotensive effects of Momordica charantia Linn (Cucurbitaceae) whole-plant aqueous extract in rats. Cardiovasc J S Afr. 2006;17:227-32 pubmed
  73. Yuyama H, Sonoda R, Shibasaki K, Fujimori A, Sudoh K, Sasamata M, et al. Effect of single oral administration of YM598, a novel selective endothelin ETA receptor antagonist, on blood pressure in normotensive and hypertensive rats. Vascul Pharmacol. 2004;41:27-34 pubmed
    ..These results also indicate the possibility of additive, but not synergic, hypotensive effects on concomitant administration of ET receptor antagonist and an L-type Ca2+ channel antagonist...
  74. Mori T, O Connor P, Abe M, Cowley A. Enhanced superoxide production in renal outer medulla of Dahl salt-sensitive rats reduces nitric oxide tubular-vascular cross-talk. Hypertension. 2007;49:1336-41 pubmed
    ..Diffusion of O(2)(*-) from mTAL to surrounding tissue could contribute to reduced bioavailability of NO, reductions of medullary blood flow, and interstitial fibrosis in the outer medulla of SS/Mcwi rats...
  75. Packard M, Saad Y, Gunning W, Gupta S, Shapiro J, Garrett M. Investigating the effect of genetic background on proteinuria and renal injury using two hypertensive strains. Am J Physiol Renal Physiol. 2009;296:F839-46 pubmed publisher
    ..These findings demonstrate that genetic context plays a significant and important role in the phenotypic expression of genes influencing proteinuria on RNO8 and RNO13...
  76. Vollenweider P. Anti-hypertensive and natriuretic effect of glucagon-like peptide 1 in Dahl S rats: a novel function for a pleotrophic hormone?. J Hypertens. 2003;21:1079-80 pubmed