inbred bn rats


Summary: An inbred strain of rat that is widely used in a variety of research areas such as the study of ASTHMA; CARCINOGENESIS; AGING; and LEUKEMIA.

Top Publications

  1. Stekelenburg A, Oomens C, Strijkers G, Nicolay K, Bader D. Compression-induced deep tissue injury examined with magnetic resonance imaging and histology. J Appl Physiol (1985). 2006;100:1946-54 pubmed
    ..Differences in damage development distal and proximal to the indenter position suggested a contribution of perfusion status in the measured tissue changes that, however, appeared be to reversible...
  2. Huang W, Fileta J, Guo Y, Grosskreutz C. Downregulation of Thy1 in retinal ganglion cells in experimental glaucoma. Curr Eye Res. 2006;31:265-71 pubmed
    ..Thy1 is a surface glycoprotein uniquely expressed in retinal ganglion cells (RGCs) in retina. The aim of this study was to investigate the expression change of Thy1 in a model of experimental glaucoma...
  3. Hoving S, Seynhaeve A, van Tiel S, aan de Wiel Ambagtsheer G, De Bruijn E, Eggermont A, et al. Early destruction of tumor vasculature in tumor necrosis factor-alpha-based isolated limb perfusion is responsible for tumor response. Anticancer Drugs. 2006;17:949-59 pubmed
    ..g. interstitial fluid pressure and pH), we speculate that the tumor vascular changes, and concurrent hemorrhage and drug accumulation are the key explanations for the observed synergistic anti-tumor response...
  4. Stekelenburg A, Strijkers G, Parusel H, Bader D, Nicolay K, Oomens C. Role of ischemia and deformation in the onset of compression-induced deep tissue injury: MRI-based studies in a rat model. J Appl Physiol (1985). 2007;102:2002-11 pubmed
    ..0. There was a good correlation between the location of damage and the location of high shear strain. It was concluded that the large deformations, in conjunction with ischemia, provided the main trigger for irreversible muscle damage...
  5. Olson J, Courtney R, Mandava N. Intravitreal infliximab and choroidal neovascularization in an animal model. Arch Ophthalmol. 2007;125:1221-4 pubmed
    ..To determine whether intravitreal infliximab can inhibit the growth of choroidal neovascularization (CNV) in an animal model of age-related macular degeneration...
  6. Seo A, Xu J, Servais S, Hofer T, Marzetti E, Wohlgemuth S, et al. Mitochondrial iron accumulation with age and functional consequences. Aging Cell. 2008;7:706-16 pubmed
    ..Overall, our data suggest that age-dependent accumulation of mitochondrial iron may increase mitochondrial dysfunction and oxidative damage,thereby enhancing the susceptibility to apoptosis...
  7. Carter C, Leeuwenburgh C, Daniels M, Foster T. Influence of calorie restriction on measures of age-related cognitive decline: role of increased physical activity. J Gerontol A Biol Sci Med Sci. 2009;64:850-9 pubmed publisher
    ..Finally, CR resulted in an overall increase in physical activity, one of several behavioral confounders to consider in the interpretation of cognitive outcomes in both tasks. ..
  8. Sheu S, Bee Y, Ma Y, Liu G, Lin H, Yeh T, et al. Inhibition of choroidal neovascularization by topical application of angiogenesis inhibitor vasostatin. Mol Vis. 2009;15:1897-905 pubmed
    ..Choroidal neovascularization (CNV) is the leading cause of blindness in patients with age-related macular degeneration (AMD). This study evaluated the inhibitory effect of vasostatin (VS), an endogenous angiogenesis inhibitor, on CNV...
  9. Marzetti E, Groban L, Wohlgemuth S, Lees H, Lin M, Jobe H, et al. Effects of short-term GH supplementation and treadmill exercise training on physical performance and skeletal muscle apoptosis in old rats. Am J Physiol Regul Integr Comp Physiol. 2008;294:R558-67 pubmed
    ..In contrast, short-term administration of GH late in life does not provide any protection against functional decline or muscle aging and may even accelerate apoptosis in slow-twitch muscles, such as the soleus. ..

More Information

Publications106 found, 100 shown here

  1. Mojumder D, Sherry D, Frishman L. Contribution of voltage-gated sodium channels to the b-wave of the mammalian flash electroretinogram. J Physiol. 2008;586:2551-80 pubmed publisher
    ..These findings indicate that activation of Na(v) channels in ON cone bipolar cells affects the b-wave of the rat ERG and must be considered when analysing results of ERG studies of retinal function...
  2. Hofer T, Marzetti E, Xu J, Seo A, Gulec S, Knutson M, et al. Increased iron content and RNA oxidative damage in skeletal muscle with aging and disuse atrophy. Exp Gerontol. 2008;43:563-70 pubmed publisher
    ..These results suggest that RNA oxidation, possibly mediated by increased non-heme iron, might contribute to muscle atrophy due to disuse particularly in aged muscle...
  3. Xu J, Knutson M, Carter C, Leeuwenburgh C. Iron accumulation with age, oxidative stress and functional decline. PLoS ONE. 2008;3:e2865 pubmed publisher
    ..These findings strongly suggest that the age-related iron accumulation in muscle contributes to increased oxidative damage and sarcopenia, and that CR effectively attenuates these negative effects...
  4. Hofer T, Servais S, Seo A, Marzetti E, Hiona A, Upadhyay S, et al. Bioenergetics and permeability transition pore opening in heart subsarcolemmal and interfibrillar mitochondria: effects of aging and lifelong calorie restriction. Mech Ageing Dev. 2009;130:297-307 pubmed publisher
    ..In summary, the age-related reduction of Ca(2+) retention capacity in IFM may explain the increased susceptibility to stress-induced cell death in the aged myocardium...
  5. Soler J, Pereira A, Torres C, Krieger J. Gene by environment QTL mapping through multiple trait analyses in blood pressure salt-sensitivity: identification of a novel QTL in rat chromosome 5. BMC Med Genet. 2006;7:47 pubmed
    ..Composite interval mapping has been extended to multiple traits and may be an interesting approach to such a problem...
  6. Blanks D, Ebert C, Eapen R, Zdanski C, Kandimalla E, Agrawal S, et al. Immune modulatory oligonucleotides in the prevention and treatment of OVA-induced eustachian tube dysfunction in rats. Otolaryngol Head Neck Surg. 2007;137:321-6 pubmed
    ..001). IMO via transtympanic application can prevent and treat allergy-induced eustachian tube dysfunction in rats. IMO may offer substantial promise in the future management of OME. ..
  7. Dammeijer P, Dijk P, Chenault M, Manni J, Mameren H. Stapedius muscle fibre characterization in the noise exposed and auditory deprived rat. Hear Res. 2007;233:54-66 pubmed
    ..Our results are also in favour of another postulated function of the SM, the unmasking of high-frequency signals in low-frequency background noise...
  8. Johnson A, Redish A. Neural ensembles in CA3 transiently encode paths forward of the animal at a decision point. J Neurosci. 2007;27:12176-89 pubmed
    ..These data suggest that the hippocampus does not represent space as a passive computation, but rather that hippocampal spatial processing is an active process likely regulated by cognitive mechanisms. ..
  9. Berdugo M, Bejjani R, Valamanesh F, Savoldelli M, Jeanny J, Blanc D, et al. Evaluation of the new photosensitizer Stakel (WST-11) for photodynamic choroidal vessel occlusion in rabbit and rat eyes. Invest Ophthalmol Vis Sci. 2008;49:1633-44 pubmed publisher
    ..Unlike verteporfin PDT, Stakel PDT does not cause direct damage to the RPE cell layer or retina. These observations indicate that Stakel PDT may have a high potential for beneficial therapeutic outcomes in treatment of AMD. ..
  10. She H, Nakazawa T, Matsubara A, Connolly E, Hisatomi T, Noda K, et al. Photoreceptor protection after photodynamic therapy using dexamethasone in a rat model of choroidal neovascularization. Invest Ophthalmol Vis Sci. 2008;49:5008-14 pubmed publisher
    ..05). Systemic administration of dexamethasone combined with PDT reduces photoreceptor apoptosis, increases angiographic closure, and reduces CNV size compared with PDT alone in a rat model. ..
  11. Riazi S, Tiwari S, Sharma N, Rash A, Ecelbarger C. Abundance of the Na-K-2Cl cotransporter NKCC2 is increased by high-fat feeding in Fischer 344 X Brown Norway (F1) rats. Am J Physiol Renal Physiol. 2009;296:F762-70 pubmed publisher
    ..Overall, HF feeding increased the abundance of NKCC2. Inappropriately high sodium reabsorption in the thick ascending limb via NKCC2 may contribute to hypertension with insulin resistance...
  12. Chen X, Tharmanathan T, Mannargudi B, Gou H, Uetrecht J. A study of the specificity of lymphocytes in nevirapine-induced skin rash. J Pharmacol Exp Ther. 2009;331:836-41 pubmed publisher
    ..This has significant implications for understanding the evolution of an immune response and the basis of the pharmacological interaction hypothesis. ..
  13. Onuta G, van Ark J, Rienstra H, Boer M, Klatter F, Bruggeman C, et al. Development of transplant vasculopathy in aortic allografts correlates with neointimal smooth muscle cell proliferative capacity and fibrocyte frequency. Atherosclerosis. 2010;209:393-402 pubmed publisher
    ..Susceptibility for transplant vasculopathy appears to be genetically controlled and correlates with neointimal smooth muscle cell proliferative capacity and circulating fibrocyte frequency. ..
  14. Spradley F, Ho D, Pollock J. Dahl SS rats demonstrate enhanced aortic perivascular adipose tissue-mediated buffering of vasoconstriction through activation of NOS in the endothelium. Am J Physiol Regul Integr Comp Physiol. 2016;310:R286-96 pubmed publisher
    ..Thus, the PVAT serves a vasoprotective role in Dahl SS rats on normal-salt diet. ..
  15. Asano S, Rice K, Kakarla S, Katta A, Desai D, Walker E, et al. Aging influences multiple indices of oxidative stress in the heart of the Fischer 344/NNia x Brown Norway/BiNia rat. Redox Rep. 2007;12:167-80 pubmed
    ..These results suggest that the aging F344/NXBN heart may be highly suited for unraveling the molecular events that lead to age-associated alterations in cardiac oxidative stress. ..
  16. Johnson M, He L, Herman D, Wakimoto H, Wallace C, Zidek V, et al. Dissection of chromosome 18 blood pressure and salt-sensitivity quantitative trait loci in the spontaneously hypertensive rat. Hypertension. 2009;54:639-45 pubmed publisher
    ..Candidate genes identified in these studies merit further investigation as potentially causative hypertension genes in SHR and human hypertension. ..
  17. Mårtensson L, Nilsson R, Ohlsson T, Sjogren H, Strand S, Tennvall J. High-dose radioimmunotherapy combined with extracorporeal depletion in a syngeneic rat tumor model: evaluation of toxicity, therapeutic effect, and tumor model. Cancer. 2010;116:1043-52 pubmed publisher
    ..Targeted RIT with beta-emitting radionuclides seems not to be effective in microscopic disease, because metastases developed at sites without previously known disease. ..
  18. Leng Y, Wei Y, Zhou S, Duan L. [Establishment of irritable bowel syndrome rat model by combination of intestinal infection with Trichinella spiralis and acute stress]. Zhonghua Yi Xue Za Zhi. 2009;89:2992-6 pubmed
    ..Aggravated by psychological factors, these rats reproduce the symptoms of intestinal dysmotility and visceral hypersensitivity. A proper animal model has been established for the investigation of IBS. ..
  19. Higgins N, Storace D, Escabi M, Read H. Specialization of binaural responses in ventral auditory cortices. J Neurosci. 2010;30:14522-32 pubmed publisher
    ..SRAF had the highest incidence of binaural facilitation for ILD cues corresponding to midline positions, supporting current theories that auditory cortices have specialized and hierarchical functional organization. ..
  20. Morris R, Laye M, Lees S, Rector R, Thyfault J, Booth F. Exercise-induced attenuation of obesity, hyperinsulinemia, and skeletal muscle lipid peroxidation in the OLETF rat. J Appl Physiol (1985). 2008;104:708-15 pubmed
    ..Therefore, even in a genetic animal model of extreme overeating, daily physical activity promotes improved health of skeletal muscle. ..
  21. Chen H, Lukas T, Du N, Suyeoka G, Neufeld A. Dysfunction of the retinal pigment epithelium with age: increased iron decreases phagocytosis and lysosomal activity. Invest Ophthalmol Vis Sci. 2009;50:1895-902 pubmed publisher
    ..Therefore, age-related changes of iron homeostasis in the RPE could increase the susceptibility of the tissue to genetic mutations associated with AMD. ..
  22. Sato M, Hirayama S, Lara Guerra H, Anraku M, Waddell T, Liu M, et al. MMP-dependent migration of extrapulmonary myofibroblast progenitors contributing to posttransplant airway fibrosis in the lung. Am J Transplant. 2009;9:1027-36 pubmed publisher
    ..In conclusion, MMP-dependent migration of PBMC-derived myofibroblast precursors is an important contributing mechanism to the development of allograft airway fibrosis...
  23. Shan J, Huang Y, Feng L, Luo L, Li C, Ke N, et al. A modified technique for heterotopic heart transplantation in rats. J Surg Res. 2010;164:155-61 pubmed publisher
    ..Our modified technique is an easily learned and reproduced procedure that allows less recipient surgical stress, a shorter operation time, and leads to a high graft and recipient survival rate. ..
  24. Yamashita T, Ohtsuka H, Arimura N, Sonoda S, Kato C, Ushimaru K, et al. Sonothrombolysis for intraocular fibrin formation in an animal model. Ultrasound Med Biol. 2009;35:1845-53 pubmed publisher
    ..No histologic damage was observed. US irradiation from outside accelerated intracameral fibrinolysis without causing apparent tissue damage. This noninvasive method might have therapeutic value for intraocular fibrin. ..
  25. Rahman N, Mori K, Mizukami M, Suzuki T, Takahashi N, Ohyama C. Role of peroxynitrite and recombinant human manganese superoxide dismutase in reducing ischemia-reperfusion renal tissue injury. Transplant Proc. 2009;41:3603-10 pubmed publisher
    ..MnSOD administration improved renal function and reduced tissue injury. It may also reduce tissue injury in acute kidney transplant rejection and other tissue injuries caused by similar molecular mechanisms. ..
  26. Baker B, Hollander M, Kashon M, Cutlip R. Effects of glutathione depletion and age on skeletal muscle performance and morphology following chronic stretch-shortening contraction exposure. Eur J Appl Physiol. 2010;108:619-30 pubmed publisher
    ..Nevertheless, we continue to show that aging negatively influences performance and morphology following chronic SSC exposure. ..
  27. Zhang C, Wang Y, Wu H, Zhang Z, Cai Y, Hou H, et al. Inhibitory efficacy of hypoxia-inducible factor 1alpha short hairpin RNA plasmid DNA-loaded poly (D, L-lactide-co-glycolide) nanoparticles on choroidal neovascularization in a laser-induced rat model. Gene Ther. 2010;17:338-51 pubmed publisher
    ..01). No signs of functional or ultrastructural destruction in retina were detected. Therefore, pshHIF-1alpha NPs may act as a novel therapeutic option to transfer specific pDNA and inhibit the formation of experimental CNV. ..
  28. Arts J, Jacobs E, Kuper C. Pre-exposure to sulfur dioxide attenuates most allergic reactions upon trimellitic anhydride challenge in sensitized Brown Norway rats. Inhal Toxicol. 2010;22:179-91 pubmed publisher
    ..However in a few animals, SO(2) appeared to facilitate TMA-induced irritation, probably due to incomplete protection. Overall, SO(2) exposure of TMA-sensitized rats reduced TMA-related allergic respiratory responses in most animals. ..
  29. de Resende M, Stodola T, Greene A. Role of the renin angiotensin system on bone marrow-derived stem cell function and its impact on skeletal muscle angiogenesis. Physiol Genomics. 2010;42:437-44 pubmed publisher
    ..This study suggests that dysregulation of the RAS in the SS/Mcwi rat contributes to impaired BM-EC function and could impact the angiogenic therapeutic potential of BMC. ..
  30. Kruschinski C, Skripuletz T, Bedoui S, Raber K, Straub R, Hoffmann T, et al. Postnatal life events affect the severity of asthmatic airway inflammation in the adult rat. J Immunol. 2008;180:3919-25 pubmed
    ..Thus, in addition to genetic and hygienic factors, nongenetically acquired individual differences contribute to the pathobiology of asthma. ..
  31. Silvani A, Bastianini S, Berteotti C, Franzini C, Lenzi P, Lo Martire V, et al. Central and baroreflex control of heart period during the wake-sleep cycle in consomic rats with different genetic susceptibility to hypertension. Clin Exp Pharmacol Physiol. 2010;37:322-7 pubmed publisher
    ..Impairments in the baroreflex and central autonomic control of HP during quiet wakefulness and REMS, respectively, cannot be generalized as an index of genetic susceptibility to hypertension. ..
  32. Grozdanic S, Lazic T, Kuehn M, Harper M, Kardon R, Kwon Y, et al. Exogenous modulation of intrinsic optic nerve neuroprotective activity. Graefes Arch Clin Exp Ophthalmol. 2010;248:1105-16 pubmed publisher
    ..001 respectively) compared to non-treated animals. Continuous release of neurotrophic growth factors (NGFs) significantly protects optic nerve function in the experimental model of retinal ischemia observed by PLR analysis. ..
  33. Pedros C, Gaud G, Bernard I, Kassem S, Chabod M, Lagrange D, et al. An Epistatic Interaction between Themis1 and Vav1 Modulates Regulatory T Cell Function and Inflammatory Bowel Disease Development. J Immunol. 2015;195:1608-16 pubmed publisher
    ..Together, these results highlight the importance of the signaling pathway involving epistasis between Themis1 and Vav1 in the control of Treg suppressive function and susceptibility to IBD development. ..
  34. Xie J, Dong J, Cui Y. [Effect of epimedium herb on RANTES and monocyte chemotactic protein-3 expression in lung tissue of asthmatic rats]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2008;28:238-41 pubmed
    ..As for level of IL-5, lowering was shown only in Group C and F (P = 0.003, P = 0.005). Applying EH in the attack stage of asthma can alleviate the airway inflammation by down-regulating the expression of RANTES and MCP-3 in lung tissue. ..
  35. Lu F, Hu Z, Sinard J, Garen A, Adelman R. Factor VII-verteporfin for targeted photodynamic therapy in a rat model of choroidal neovascularization. Invest Ophthalmol Vis Sci. 2009;50:3890-6 pubmed publisher
    ..The efficacious dose with fVII-verteporfin was approximately 10% of the dose usually used in nontargeted Visudyne PDT. Using fVII-verteporfin for TPT may improve the efficacy and safety of PDT for treating choroidal neovascularization. ..
  36. Kerr A, Hensel M, Peterson T, Villatoro L, NYE S, Swain R. Introgression of Brown Norway chromosome 13 improves visual spatial memory in the Dahl S rat. Behav Genet. 2010;40:76-84 pubmed publisher
    ..These animals may represent a natural animal model in which to isolate genetic information responsible for learning and memory function. ..
  37. Ouyang J, He J, Fan Y, Fan C, Sun H, Wen D. [Expressions of interleukin-15 and osteopontin mRNA in early stage of acute rejection of renal allograft in rats]. Zhonghua Yi Xue Za Zhi. 2010;90:698-702 pubmed
    ..In early stage of AR of renal allograft in rats, the expressions of OPN, IL-15, PFP and GraB mRNA are up-regulated. Blocking IL-15/IL-15R pathway in early stage of AR can down-regulate the expressions of PFP and GraB mRNA. ..
  38. Careau E, Turmel V, Lauzon Joset J, Bissonnette E. Alveolar macrophages reduce airway hyperresponsiveness and modulate cytokine levels. Exp Lung Res. 2010;36:255-61 pubmed publisher
    ..Our data suggest that AM modulation of cytokine milieu is involved in the reduction of airway hyperresponsiveness. ..
  39. Gong J, Cao D, Chen Y, Li J, Gong J, Zeng Z. Role of programmed death ligand 1 and Kupffer cell in immune regulation after orthotopic liver transplantation in rats. Int Immunopharmacol. 2017;48:8-16 pubmed publisher
    ..05). KCs with high expression of PD-L1 could significantly suppress the proliferation and function of TCs. Silencing the expression of PD-L1 in KCs in vivo could restore the function of TCs. ..
  40. Nestvold J, Omdal B, Dai K, Martens A, Benestad H, Vaage J, et al. A second prophylactic MHC-mismatched bone marrow transplantation protects against rat acute myeloid leukemia (BNML) without lethal graft-versus-host disease. Transplantation. 2008;85:102-11 pubmed publisher
    ..A second prophylactic transplantation influenced the degree of T-cell chimerism to balance favorably between GVL and GVHD. If applicable to humans, repeated alloBMT may provide a novel approach to leukemia therapy. ..
  41. Toyokawa H, Nakao A, Bailey R, Nalesnik M, Kaizu T, Lemoine J, et al. Relative contribution of direct and indirect allorecognition in developing tolerance after liver transplantation. Liver Transpl. 2008;14:346-57 pubmed publisher
    ..In conclusion, the study suggests that host cells with phagocytic activity could play significant roles in developing LT tolerance. ..
  42. Zadro Lamoureux L, Zacks D, Baker A, Zheng Q, Hauswirth W, Tsilfidis C. XIAP effects on retinal detachment-induced photoreceptor apoptosis [corrected]. Invest Ophthalmol Vis Sci. 2009;50:1448-53 pubmed publisher
    ..The results suggest that XIAP confers structural neuroprotection of photoreceptors for at least 2 months after retinal detachment. ..
  43. Pruett B, Salvatore M. GFR ?-1 receptor expression in the aging nigrostriatal and mesoaccumbens pathways. J Neurochem. 2010;115:707-15 pubmed publisher
  44. Mårtensson L, Nilsson R, Ohlsson T, Sjogren H, Strand S, Tennvall J. Improved tumor targeting and decreased normal tissue accumulation through extracorporeal affinity adsorption in a two-step pretargeting strategy. Clin Cancer Res. 2007;13:5572s-5576s pubmed
    ..Conversely, the use of ECAT for removal of radiolabeled streptavidin seems not to offer any advantage. ..
  45. Sutherland J, Page M, Conti L. The effect of corticotropin-releasing factor on prepulse inhibition is independent of serotonin in Brown Norway and Wistar-Kyoto rats. Pharmacol Biochem Behav. 2008;89:324-37 pubmed publisher
    ..3 microg or 3.0 microg). CRF decreased PPI despite 5-HT depletion. These findings suggest that CRF does not decrease PPI via effects on 5-HT, since neither blockade of 5-HT(2A/C) receptors nor 5-HT depletion attenuated this decrease. ..
  46. Suzuki T, Sasaki T, Takagi H, Sato K, Ueda K. The effectors responsible for gastrointestinal nematode parasites, Trichinella spiralis, expulsion in rats. Parasitol Res. 2008;103:1289-95 pubmed publisher
    ..Therefore, the present study suggests that mast cells should also be one of the prominent effector cells involved in T. spiralis parasite expulsion in rats as well as mice. ..
  47. Hughes L, Turner J, Parrish J, Caspary D. Processing of broadband stimuli across A1 layers in young and aged rats. Hear Res. 2010;264:79-85 pubmed publisher
    ..The present findings were also consistent with aging studies suggesting loss of functional inhibition in other cortical sensory systems. ..
  48. Alawieh M, Rifle G, Bouchot O, Malapert G, Mousson C, Martin L. Injection of donor-derived OX62+ splenic dendritic cells with anti-CD4 monoclonal antibody generates CD4+CD25+FOXP3+ regulatory T cells that prolong allograft skin survival indefinitely and abrogate production of donor-specific antibodies in a rat mo. Transplant Proc. 2009;41:3363-6 pubmed publisher
    ..05). JDO-BMSCs can promote the survival of allogeneic composite tissue grafts in rats, and its mechanism may involve in inhibition of T lymphocytes proliferation and promotion their own colonization in allograft. ..
  50. Trifilieff A, Baur F, Fozard J. Role of sphingosine-1-phosphate (S1P) and the S1P(2) receptor in allergen-induced, mast cell-dependent contraction of rat lung parenchymal strips. Naunyn Schmiedebergs Arch Pharmacol. 2009;380:303-9 pubmed publisher
    ..These data demonstrate the importance of S1P and the S1P(2) receptor as regulators of allergen-induced activation of mast cells in their natural environment in the rat lung...
  51. Goyal R, Yellon S, Longo L, Mata Greenwood E. Placental gene expression in a rat 'model' of placental insufficiency. Placenta. 2010;31:568-75 pubmed publisher
    ..Recent studies have identified the Brown Norway (BN) rat as a natural 'model' of placental insufficiency associated with decreased trophoblast remodeling of maternal uterine arteries...
  52. Pravenec M, Hyakukoku M, Houstek J, Zidek V, Landa V, Mlejnek P, et al. Direct linkage of mitochondrial genome variation to risk factors for type 2 diabetes in conplastic strains. Genome Res. 2007;17:1319-26 pubmed
  53. Gratton M, Bateman K, Cannuscio J, Saunders J. Outer- and middle-ear contributions to presbycusis in the Brown Norway rat. Audiol Neurootol. 2008;13:37-52 pubmed
    ..0 and 20.0 kHz and reached a maximum of approximately 15 dB. These results support the conclusion that there is an outer- and middle-ear contribution to the threshold loss defining presbycusis...
  54. Huang Y, Xu G, Peng Y, Lin H, Zheng X, Xie M. Zinc phthalocyanine tetrasulfonate (ZnPcS4): a new photosensitizer for photodynamic therapy in choroidal neovascularization. J Ocul Pharmacol Ther. 2007;23:377-86 pubmed
  55. Wagner J, Jiang Q, Harkema J, Ames B, Illek B, Roubey R, et al. Gamma-tocopherol prevents airway eosinophilia and mucous cell hyperplasia in experimentally induced allergic rhinitis and asthma. Clin Exp Allergy. 2008;38:501-11 pubmed
  56. Karlsson S, Klinga Levan K. Expression analysis of human endometrial adenocarcinoma in an inbred rat model. Adv Exp Med Biol. 2008;617:503-9 pubmed publisher
    ..Several of the genes identified are involved in pathways commonly altered in carcinogenesis, such as the TGF-pathway...
  57. Rice K, Wu M, Blough E. Aortic aging in the Fischer 344 / NNiaHSd x Brown Norway / BiNia Rat. J Pharmacol Sci. 2008;108:393-8 pubmed
    ..Here we examine the current literature regarding the F344BN, focusing on age-associated changes in aortic structure and function...
  58. Buie L, Rasmussen C, Porterfield E, Ramgolam V, Choi V, Markovic Plese S, et al. Self-complementary AAV virus (scAAV) safe and long-term gene transfer in the trabecular meshwork of living rats and monkeys. Invest Ophthalmol Vis Sci. 2010;51:236-48 pubmed publisher
    ..The goal was to investigate the ability of AAV vectors to induce long-term, safe delivery of transgenes to the trabecular meshwork of living animals...
  59. Jungraithmayr W, Ji L, Yang L, Weder W, Korom S, Hersberger M. Increased T-bet to GATA-3 ratio during acute allograft rejection in the rat lung. Transplant Proc. 2009;41:4316-20 pubmed publisher
    ..This study suggests that T(h)1 responses play a major role during AR in the rat lung, and that this differentiation can be monitored by measuring mRNA levels of T-bet and GATA-3...
  60. Rice K, Walker E, Kakarla S, Paturi S, Wu M, Narula S, et al. Fluprostenol-induced MAPK signaling is independent of aging in Fischer 344/NNiaHSd x Brown Norway/BiNia rat aorta. Ann Clin Lab Sci. 2010;40:26-31 pubmed
    ..These findings suggest that aging does not affect the ability of the rat aorta to activate ERK(1/2)-, p38-MAPK, and JNK-MAPK phosphorylation in response to PGF2alpha stimulation...
  61. Moeller L, Alonso M, Liao X, Broach V, Dumitrescu A, van Sande J, et al. Pituitary-thyroid setpoint and thyrotropin receptor expression in consomic rats. Endocrinology. 2007;148:4727-33 pubmed
    ..These strains of rat provide a model to study the cis- and trans-acting factors underlying the difference in TSHR expression...
  62. Deuse T, Velotta J, Hoyt G, Govaert J, Taylor V, Masuda E, et al. Novel immunosuppression: R348, a JAK3- and Syk-inhibitor attenuates acute cardiac allograft rejection. Transplantation. 2008;85:885-92 pubmed publisher
    ..Janus kinase (JAK)3 is crucial for signal transduction downstream of various cytokine receptors in immune cells. This is the first report on the novel JAK3 inhibitor R348...
  63. Calvisi D, Pinna F, Ladu S, Pellegrino R, Muroni M, Simile M, et al. Aberrant iNOS signaling is under genetic control in rodent liver cancer and potentially prognostic for the human disease. Carcinogenesis. 2008;29:1639-47 pubmed publisher
    ..These findings indicate that iNOS cross talk with NF-kB and Ha-RAS/ERK cascades influences HCC growth and prognosis, suggesting that key component of iNOS signaling could represent important therapeutic targets for human HCC...
  64. Ergorul C, Ray A, Huang W, Darland D, Luo Z, Grosskreutz C. Levels of vascular endothelial growth factor-A165b (VEGF-A165b) are elevated in experimental glaucoma. Mol Vis. 2008;14:1517-24 pubmed
  65. Stax A, Gelderman K, Schlagwein N, Essers M, Kamerling S, Woltman A, et al. Induction of donor-specific T-cell hyporesponsiveness using dexamethasone-treated dendritic cells in two fully mismatched rat kidney transplantation models. Transplantation. 2008;86:1275-82 pubmed publisher
    ..Here, we investigated the immunoregulatory role of DexDC in two different rat acute rejection models of kidney transplantation...
  66. Zhu J, Wang Y, Zhang J, Zhao W, Yang X, Li X, et al. Focal adhesion kinase signaling pathway participates in the formation of choroidal neovascularization and regulates the proliferation and migration of choroidal microvascular endothelial cells by acting through HIF-1 and VEGF expression in RPE cells. Exp Eye Res. 2009;88:910-8 pubmed publisher
  67. Lee E, Rewolinski D. Evaluation of CXCR4 inhibition in the prevention and intervention model of laser-induced choroidal neovascularization. Invest Ophthalmol Vis Sci. 2010;51:3666-72 pubmed publisher
    ..A multiple receptor tyrosine kinase (RTK) inhibitor approach shows promise for the treatment of wet age-related macular degeneration...
  68. Sugito K, Inoue M, Ikeda T, Hagiwara N, Koshinaga T, Kusafuka T. Effect of FTY720 and ex vivo graft irradiation in rat small bowel transplantation: expression of mucosal addressin cell adhesion molecule-1. Surg Today. 2008;38:38-41 pubmed
  69. Nissirios N, Chanis R, Johnson E, Morrison J, Cepurna W, Jia L, et al. Comparison of anterior segment structures in two rat glaucoma models: an ultrasound biomicroscopic study. Invest Ophthalmol Vis Sci. 2008;49:2478-82 pubmed publisher
    ..This study was undertaken to investigate whether anterior chamber (AC) changes develop in two popular models in vivo and whether the changes are related to IOP...
  70. Li F, Zhang L, Craddock J, Bruce Keller A, Dasuri K, Nguyen A, et al. Aging and dietary restriction effects on ubiquitination, sumoylation, and the proteasome in the heart. Mech Ageing Dev. 2008;129:515-21 pubmed publisher
  71. Pan H, Wang L, Zhang X, Zhang G, Mai H, Han Y, et al. Rapamycin, mycophenolate mofetil, methylprednisolone, and cytotoxic T-lymphocyte-associated antigen 4 immunoglobulin-based conditioning regimen to induce partial tolerance to hind limb allografts without cytoreductive conditioning. Transplant Proc. 2008;40:1714-21 pubmed publisher
    ..In this study, we investigated a nontoxic immunosuppressant and cytotoxic T-lymphocyte-associated antigen 4 immunoglobulin (CTLA4-Ig)-based protocol to induce donor-specific tolerance to hind limb allografts in rats...
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    ..In addition, EP(3) receptor also participates in sneezing in allergic rhinitis induced by TDI challenge in BN rats...
  74. Ricci D, Mennander A, Miyagi N, Rao V, Tazelaar H, Classic K, et al. Prolonged cardiac allograft survival using iodine 131 after human sodium iodide symporter gene transfer in a rat model. Transplant Proc. 2010;42:1888-94 pubmed publisher
    ..Radioiodine is efficiently concentrated by tissues expressing the human sodium iodide symporter (hNIS)...
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    ..To observe the effects of ketamine on bronchial hyperresponsiveness and airway inflammation in equal asthma...
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    ..This animal model provides a versatile and robust experimental tool to evaluate and assess at least some features of MDI-related asthma...
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    ..These results suggest that the production of sulfomucin and expression of Gal3STs are inducible by nematode infection without the activation of thymus-derived T cells...
  79. Lees S, Childs T, Booth F. Age-dependent FOXO regulation of p27Kip1 expression via a conserved binding motif in rat muscle precursor cells. Am J Physiol Cell Physiol. 2008;295:C1238-46 pubmed publisher
    ..These findings have implications for developing treatment strategies aimed at increasing the proliferation of MPCs and regenerative capacity of aged skeletal muscle...
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    ..The up-regulation of IL-12 reflects an early response after allo-antigen exposure, indicating a strong impact of the initiation of the T(h)1 pathway at an early phase during acute lung rejection...
  82. Kigasawa K, Kajimoto K, Hama S, Saito A, Kanamura K, Kogure K. Noninvasive delivery of siRNA into the epidermis by iontophoresis using an atopic dermatitis-like model rat. Int J Pharm. 2010;383:157-60 pubmed publisher
    ..In conclusion, we successfully delivered naked siRNA into the epidermis and concomitantly suppressed the expression of an endogenous immuno-regulatory cytokine...
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    ..This is a report of an investigation of the effect of 5-S-GAD (eyedrops) on UVB-induced cataracts in rats...
  84. Guo Y, Cepurna W, Dyck J, Doser T, Johnson E, Morrison J. Retinal cell responses to elevated intraocular pressure: a gene array comparison between the whole retina and retinal ganglion cell layer. Invest Ophthalmol Vis Sci. 2010;51:3003-18 pubmed publisher
    ..To determine and compare gene expression patterns in the whole retina and retinal ganglion cell layer (RGCL) in a rodent glaucoma model...
  85. Marengo B, De Ciusis C, Ricciarelli R, Romano P, Passalacqua M, Marinari U, et al. DNA oxidative damage of neoplastic rat liver lesions. Oncol Rep. 2010;23:1241-6 pubmed
    ..On the other hand, the enhancement of GSH levels and the down-regulation of superoxide dismutase (SOD) expression in both rat strains suggest that antioxidant response is not involved in the acquisition of resistant phenotype...
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    ..To determine if enzymatic induction of a posterior vitreous detachment (PVD) and/or vitreous liquefaction affects O2 concentration in the vitreous cavity in animals with vascularized and avascular retinal circulations...
  88. Cheruvu N, Amrite A, Kompella U. Effect of eye pigmentation on transscleral drug delivery. Invest Ophthalmol Vis Sci. 2008;49:333-41 pubmed publisher
    ..To determine the influence of eye pigmentation on transscleral retinal delivery of celecoxib...
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    ..The KMI strain is the first and only rat model with a confirmed mutation in Prkg2 and is a valuable model for studying dwarfism and longitudinal growth traits in humans and for functional studies of cGKII...