inbred bb rats

Summary

Summary: A strain of Rattus norvegicus which is a model for spontaneous insulin-dependent diabetes mellitus (DIABETES MELLITUS, INSULIN-DEPENDENT).

Top Publications

  1. Colle E, Fuks A, Poussier P, Edouard P, Guttmann R. Polygenic nature of spontaneous diabetes in the rat. Permissive MHC haplotype and presence of the lymphopenic trait of the BB rat are not sufficient to produce susceptibility. Diabetes. 1992;41:1617-23 pubmed
    ..Breeding studies in which these animals were crossed with BB and hBB rats suggest that other genes are necessary for development of overt diabetes...
  2. Ramanathan S, Bihoreau M, Paterson A, Marandi L, Gauguier D, Poussier P. Thymectomy and radiation-induced type 1 diabetes in nonlymphopenic BB rats. Diabetes. 2002;51:2975-81 pubmed
    ..This novel model of TX-R-induced diabetes in nonlymphopenic BB rats can be used to identify environmental and cellular factors that are responsible for the initiation of antipancreatic autoimmunity...
  3. MacMurray A, Moralejo D, Kwitek A, Rutledge E, Van Yserloo B, Gohlke P, et al. Lymphopenia in the BB rat model of type 1 diabetes is due to a mutation in a novel immune-associated nucleotide (Ian)-related gene. Genome Res. 2002;12:1029-39 pubmed
    ..The lymphopenia mutation may thus be useful not only to elucidate Type 1 diabetes, but also in the function of the Ian gene family as a whole...
  4. Zhang W, Yorek M, Pierson C, Murakawa Y, Breidenbach A, Sima A. Human C-peptide dose dependently prevents early neuropathy in the BB/Wor-rat. Int J Exp Diabetes Res. 2001;2:187-93 pubmed
    ..We conclude that hrC-peptide exerts a dose dependent protection on type 1 diabetic neuropathy in rats and that this effect is probably mediated by the partially conserved sequence of the active C-terminal pentapeptide...
  5. Xu G, Pierson C, Murakawa Y, Sima A. Altered tubulin and neurofilament expression and impaired axonal growth in diabetic nerve regeneration. J Neuropathol Exp Neurol. 2002;61:164-75 pubmed
    ..The absence of this upregulation in diabetic animals may impair its regulatory effect on NF expression and contribute to perturbed nerve regeneration seen in diabetic nerve...
  6. Pierson C, Zhang W, Murakawa Y, Sima A. Early gene responses of trophic factors in nerve regeneration differ in experimental type 1 and type 2 diabetic polyneuropathies. J Neuropathol Exp Neurol. 2002;61:857-71 pubmed
    ..These differences may account for the more efficient nerve regeneration seen in type 2 diabetic polyneuropathy...
  7. Brugman S, Klatter F, Visser J, Wildeboer Veloo A, Harmsen H, Rozing J, et al. Antibiotic treatment partially protects against type 1 diabetes in the Bio-Breeding diabetes-prone rat. Is the gut flora involved in the development of type 1 diabetes?. Diabetologia. 2006;49:2105-8 pubmed
    ..This study was designed to investigate the possible relationship between the development of diabetes and the composition of intestinal flora...
  8. Zipris D, Hillebrands J, Welsh R, Rozing J, Xie J, Mordes J, et al. Infections that induce autoimmune diabetes in BBDR rats modulate CD4+CD25+ T cell populations. J Immunol. 2003;170:3592-602 pubmed
  9. Carter C, Dion C, Schnell S, Coadwell W, Graham M, Hepburn L, et al. A natural hypomorphic variant of the apoptosis regulator Gimap4/IAN1. J Immunol. 2007;179:1784-95 pubmed
    ..Nevertheless, when wild rat DNA samples were studied the AT(+) allele was found at a high overall frequency ( approximately 30%). This suggests an adaptive significance for this hypomorphic allele...
  10. Hessner M, Wang X, Meyer L, Geoffrey R, Jia S, Fuller J, et al. Involvement of eotaxin, eosinophils, and pancreatic predisposition in development of type 1 diabetes mellitus in the BioBreeding rat. J Immunol. 2004;173:6993-7002 pubmed
    ..These data support an important role for these inflammatory mediators in BB rat T1DM and suggest that the lymphopenia due to the Ian5/(lyp) mutation may result in a deregulation of cells involved in insulitis and beta cell destruction...

Detail Information

Publications78

  1. Colle E, Fuks A, Poussier P, Edouard P, Guttmann R. Polygenic nature of spontaneous diabetes in the rat. Permissive MHC haplotype and presence of the lymphopenic trait of the BB rat are not sufficient to produce susceptibility. Diabetes. 1992;41:1617-23 pubmed
    ..Breeding studies in which these animals were crossed with BB and hBB rats suggest that other genes are necessary for development of overt diabetes...
  2. Ramanathan S, Bihoreau M, Paterson A, Marandi L, Gauguier D, Poussier P. Thymectomy and radiation-induced type 1 diabetes in nonlymphopenic BB rats. Diabetes. 2002;51:2975-81 pubmed
    ..This novel model of TX-R-induced diabetes in nonlymphopenic BB rats can be used to identify environmental and cellular factors that are responsible for the initiation of antipancreatic autoimmunity...
  3. MacMurray A, Moralejo D, Kwitek A, Rutledge E, Van Yserloo B, Gohlke P, et al. Lymphopenia in the BB rat model of type 1 diabetes is due to a mutation in a novel immune-associated nucleotide (Ian)-related gene. Genome Res. 2002;12:1029-39 pubmed
    ..The lymphopenia mutation may thus be useful not only to elucidate Type 1 diabetes, but also in the function of the Ian gene family as a whole...
  4. Zhang W, Yorek M, Pierson C, Murakawa Y, Breidenbach A, Sima A. Human C-peptide dose dependently prevents early neuropathy in the BB/Wor-rat. Int J Exp Diabetes Res. 2001;2:187-93 pubmed
    ..We conclude that hrC-peptide exerts a dose dependent protection on type 1 diabetic neuropathy in rats and that this effect is probably mediated by the partially conserved sequence of the active C-terminal pentapeptide...
  5. Xu G, Pierson C, Murakawa Y, Sima A. Altered tubulin and neurofilament expression and impaired axonal growth in diabetic nerve regeneration. J Neuropathol Exp Neurol. 2002;61:164-75 pubmed
    ..The absence of this upregulation in diabetic animals may impair its regulatory effect on NF expression and contribute to perturbed nerve regeneration seen in diabetic nerve...
  6. Pierson C, Zhang W, Murakawa Y, Sima A. Early gene responses of trophic factors in nerve regeneration differ in experimental type 1 and type 2 diabetic polyneuropathies. J Neuropathol Exp Neurol. 2002;61:857-71 pubmed
    ..These differences may account for the more efficient nerve regeneration seen in type 2 diabetic polyneuropathy...
  7. Brugman S, Klatter F, Visser J, Wildeboer Veloo A, Harmsen H, Rozing J, et al. Antibiotic treatment partially protects against type 1 diabetes in the Bio-Breeding diabetes-prone rat. Is the gut flora involved in the development of type 1 diabetes?. Diabetologia. 2006;49:2105-8 pubmed
    ..This study was designed to investigate the possible relationship between the development of diabetes and the composition of intestinal flora...
  8. Zipris D, Hillebrands J, Welsh R, Rozing J, Xie J, Mordes J, et al. Infections that induce autoimmune diabetes in BBDR rats modulate CD4+CD25+ T cell populations. J Immunol. 2003;170:3592-602 pubmed
  9. Carter C, Dion C, Schnell S, Coadwell W, Graham M, Hepburn L, et al. A natural hypomorphic variant of the apoptosis regulator Gimap4/IAN1. J Immunol. 2007;179:1784-95 pubmed
    ..Nevertheless, when wild rat DNA samples were studied the AT(+) allele was found at a high overall frequency ( approximately 30%). This suggests an adaptive significance for this hypomorphic allele...
  10. Hessner M, Wang X, Meyer L, Geoffrey R, Jia S, Fuller J, et al. Involvement of eotaxin, eosinophils, and pancreatic predisposition in development of type 1 diabetes mellitus in the BioBreeding rat. J Immunol. 2004;173:6993-7002 pubmed
    ..These data support an important role for these inflammatory mediators in BB rat T1DM and suggest that the lymphopenia due to the Ian5/(lyp) mutation may result in a deregulation of cells involved in insulitis and beta cell destruction...
  11. Pierson C, Zhang W, Sima A. Proinsulin C-peptide replacement in type 1 diabetic BB/Wor-rats prevents deficits in nerve fiber regeneration. J Neuropathol Exp Neurol. 2003;62:765-79 pubmed
    ..We conclude that impaired insulin action may be more important than hyperglycemia in suppressing nerve fiber regeneration in type 1 diabetic neuropathy...
  12. Geoffrey R, Jia S, Kwitek A, Woodliff J, Ghosh S, Lernmark A, et al. Evidence of a functional role for mast cells in the development of type 1 diabetes mellitus in the BioBreeding rat. J Immunol. 2006;177:7275-86 pubmed
    ..05) delayed T1DM onset. These findings are consistent with a growing body of evidence in human and animal models, where a role for mast cells in the initiation and progression of autoimmune disease is emerging...
  13. Zhang W, Slusher B, Murakawa Y, Wozniak K, Tsukamoto T, Jackson P, et al. GCPII (NAALADase) inhibition prevents long-term diabetic neuropathy in type 1 diabetic BB/Wor rats. J Neurol Sci. 2002;194:21-8 pubmed
    ..4-17.21; previously termed NAALADase), an enzyme responsible for the hydrolysis of the neuropeptide NAAG to NAA and glutamate, on the development of DPN in type 1 diabetic BB/Wor rats...
  14. Fuller J, Kwitek A, Hawkins T, Moralejo D, Lu W, Tupling T, et al. Introgression of F344 rat genomic DNA on BB rat chromosome 4 generates diabetes-resistant lymphopenic BB rats. Diabetes. 2006;55:3351-7 pubmed
    ..Spontaneous diabetes in the BB rat may therefore be controlled, in part, by a diabetogenic factor(s), perhaps unrelated to the Gimap5 mutation on rat chromosome 4...
  15. Jackerott M, Hornum L, Andreasen B, Markholst H. Segregation of autoimmune type 1 diabetes in a cross between diabetic BB and brown Norway rats. J Autoimmun. 1997;10:35-41 pubmed
    ..Finally, the BN-derived non-albino allele of the C gene was associated with higher diabetes incidence. This points to the existence of minor susceptibility genes in other strains of rats...
  16. Kamiya H, Zhang W, Sima A. C-peptide prevents nociceptive sensory neuropathy in type 1 diabetes. Ann Neurol. 2004;56:827-35 pubmed
  17. Stevens M, Zhang W, Li F, Sima A. C-peptide corrects endoneurial blood flow but not oxidative stress in type 1 BB/Wor rats. Am J Physiol Endocrinol Metab. 2004;287:E497-505 pubmed
    ..Sensory nerve deficits are not an inevitable consequence of increased oxidative stress and decreased nerve perfusion in a type 2 diabetic rodent model...
  18. Pierson C, Zhang W, Murakawa Y, Sima A. Insulin deficiency rather than hyperglycemia accounts for impaired neurotrophic responses and nerve fiber regeneration in type 1 diabetic neuropathy. J Neuropathol Exp Neurol. 2003;62:260-71 pubmed
  19. Kloting I, van den Brandt J, Kuttler B. Genes of SHR rats protect spontaneously diabetic BB/OK rats from diabetes: lessons from congenic BB.SHR rat strains. Biochem Biophys Res Commun. 2001;283:399-405 pubmed
    ..It is supposed that diabetes protective genes of SHR must be located on both chromosomal segments and that these suppress the action of the essential and most important genes of diabetes development in the BB/OK rat, Iddm1, and Iddm2...
  20. Visser J, Brugman S, Klatter F, Vis L, Groen H, Strubbe J, et al. Short-term dietary adjustment with a hydrolyzed casein-based diet postpones diabetes development in the diabetes-prone BB rat. Metabolism. 2003;52:333-7 pubmed
    ..The shift in cytokine profile of MLNC of the HC-fed rats suggests that mechanisms involved can be at the level of both the (mucosal) immune system and the beta cell...
  21. Weiss H, Bleich A, Hedrich H, Kölsch B, Elsner M, Jörns A, et al. Genetic analysis of the LEW.1AR1-iddm rat: an animal model for spontaneous diabetes mellitus. Mamm Genome. 2005;16:432-41 pubmed
    ..1AR1-iddm rat strain will pave the way toward a detailed characterization of the loci conferring diabetes development as well as their functional relevance for the pathogenesis of type 1 diabetes mellitus...
  22. Klaff L, Koike G, Jiang J, Wang Y, Bieg S, Pettersson A, et al. BB rat diabetes susceptibility and body weight regulation genes colocalize on chromosome 2. Mamm Genome. 1999;10:883-7 pubmed
    ..008). In conclusion, the development of Type 1 diabetes in the congenic DR(lyp/lyp) rat is controlled by at least three genes: lymphopenia, MHC, and a third factor that may play a role in metabolism and body weight regulation...
  23. Schwartz R, Neu J, Schatz D, Atkinson M, Wasserfall C. Comment on: Brugman S et al. (2006) Antibiotic treatment partially protects against type 1 diabetes in the Bio-Breeding diabetes-prone rat. Is the gut flora involved in the development of type 1 diabetes? Diabetologia 49:2105-2108. Diabetologia. 2007;50:220-1 pubmed
  24. Tirabassi R, Flanagan J, Wu T, Kislauskis E, Birckbichler P, Guberski D. The BBZDR/Wor rat model for investigating the complications of type 2 diabetes mellitus. ILAR J. 2004;45:292-302 pubmed
    ..In this review, recent work that has evaluated type 2 diabetic complications in BBZDR/Wor rats is discussed, including the authors' preliminary unpublished studies on cardiovascular disease...
  25. Kamiya H, Murakawa Y, Zhang W, Sima A. Unmyelinated fiber sensory neuropathy differs in type 1 and type 2 diabetes. Diabetes Metab Res Rev. 2005;21:448-58 pubmed
    ..Degeneration of sensory C-fibers in peripheral nerve plays a prominent role in the generation of neuropathic pain. We examined degenerative changes of C-fibers in two rat models with type 1 and type 2 diabetes...
  26. Blankenhorn E, Rodemich L, Martin Fernandez C, Leif J, Greiner D, Mordes J. The rat diabetes susceptibility locus Iddm4 and at least one additional gene are required for autoimmune diabetes induced by viral infection. Diabetes. 2005;54:1233-7 pubmed
  27. Hornum L, Rømer J, Markholst H. The diabetes-prone BB rat carries a frameshift mutation in Ian4, a positional candidate of Iddm1. Diabetes. 2002;51:1972-9 pubmed
    ..We propose that Ian4 is identical to Iddm1...
  28. Kamiya H, Zhangm W, Sima A. Apoptotic stress is counterbalanced by survival elements preventing programmed cell death of dorsal root ganglions in subacute type 1 diabetic BB/Wor rats. Diabetes. 2005;54:3288-95 pubmed
  29. Fernyhough P, Gallagher A, Averill S, Priestley J, Hounsom L, Patel J, et al. Aberrant neurofilament phosphorylation in sensory neurons of rats with diabetic neuropathy. Diabetes. 1999;48:881-9 pubmed
    ..It is hypothesized that in sensory neurons of diabetic rats, aberrant phosphorylation of neurofilament may contribute to the distal sensory axonopathy observed in diabetes...
  30. Poussier P, Ning T, Murphy T, Dabrowski D, Ramanathan S. Impaired post-thymic development of regulatory CD4+25+ T cells contributes to diabetes pathogenesis in BB rats. J Immunol. 2005;174:4081-9 pubmed
  31. Caicedo R, Li N, des Robert C, Scumpia P, Hubsher C, Wasserfall C, et al. Neonatal formula feeding leads to immunological alterations in an animal model of type 1 diabetes. Pediatr Res. 2008;63:303-7 pubmed
    ..002) compared with MF animals. Formula versus maternal milk altered the hepatic cytokine profile at 75 d toward an inflammatory pattern but did not result in altered T(reg) cell frequencies or the development of T1D...
  32. Zhang W, Kamiya H, Ekberg K, Wahren J, Sima A. C-peptide improves neuropathy in type 1 diabetic BB/Wor-rats. Diabetes Metab Res Rev. 2007;23:63-70 pubmed
    ..Here we examine the therapeutic effects of C-peptide, delivered as continuous infusion or once daily subcutaneous injections on established DPN...
  33. Sima A, Li Z. The effect of C-peptide on cognitive dysfunction and hippocampal apoptosis in type 1 diabetic rats. Diabetes. 2005;54:1497-505 pubmed
    ..Although these abnormalities were not fully prevented by C-peptide replacement, the findings suggest that this regime will substantially prevent cognitive decline in the type 1 diabetic population...
  34. Kloting I, van den Brandt J, Kloting N, Radovic B. Alleles of diabetes-resistant BN rats contribute to insulin-dependent type 1 diabetes mellitus. J Autoimmun. 2003;20:119-23 pubmed
    ..We conclude that BN rats possess more than one gene contributing to type 1 diabetes development...
  35. Kamiya H, Zhang W, Ekberg K, Wahren J, Sima A. C-Peptide reverses nociceptive neuropathy in type 1 diabetes. Diabetes. 2006;55:3581-7 pubmed
    ..We conclude that C-peptide exerts beneficial therapeutic effects on diabetic nociceptive neuropathy and that optimal effects require maintenance of physiological C-peptide concentrations for a major proportion of the day...
  36. Michalkiewicz M, Michalkiewicz T, Ettinger R, Rutledge E, Fuller J, Moralejo D, et al. Transgenic rescue demonstrates involvement of the Ian5 gene in T cell development in the rat. Physiol Genomics. 2004;19:228-32 pubmed
    ..It also demonstrates that transgenic rescue in the rat is a practical and definitive method for revealing the function of a novel gene...
  37. Kloting I, Schmidt S, Kovacs P. Mapping of novel genes predisposing or protecting diabetes development in the BB/OK rat. Biochem Biophys Res Commun. 1998;245:483-6 pubmed
    ..From these novel findings it is concluded that the diabetogenic phenotype of the BB/OK rat subline is the result of the interaction of predisposing and protecting diabetes genes...
  38. Sima A, Zhang W, Li Z, Murakawa Y, Pierson C. Molecular alterations underlie nodal and paranodal degeneration in type 1 diabetic neuropathy and are prevented by C-peptide. Diabetes. 2004;53:1556-63 pubmed
    ..These data describe for the first time the progressive molecular aberrations underlying nodal and paranodal degenerative changes in type 1 diabetic neuropathy and demonstrate that they are preventable by insulinomimetic C-peptide...
  39. Li Z, Zhang W, Grunberger G, Sima A. Hippocampal neuronal apoptosis in type 1 diabetes. Brain Res. 2002;946:221-31 pubmed
    ..The data also suggest that this is at least in part related to impaired insulin and/or IGF activities...
  40. Li Z, Zhang W, Sima A. The role of impaired insulin/IGF action in primary diabetic encephalopathy. Brain Res. 2005;1037:12-24 pubmed
    ..The findings suggest that insulin deficiency plays a compounding role to that of hyperglycemia in neuronal apoptosis underpinning primary diabetic encephalopathy...
  41. Neu J, Reverte C, Mackey A, Liboni K, Tuhacek Tenace L, Hatch M, et al. Changes in intestinal morphology and permeability in the biobreeding rat before the onset of type 1 diabetes. J Pediatr Gastroenterol Nutr. 2005;40:589-95 pubmed
    ..In these studies, we examined both the physical and functional permeability characteristics of the small intestine in diabetes-prone and control rats...
  42. Martin A, Blankenhorn E, Maxson M, Zhao M, Leif J, Mordes J, et al. Non-major histocompatibility complex-linked diabetes susceptibility loci on chromosomes 4 and 13 in a backcross of the DP-BB/Wor rat to the WF rat. Diabetes. 1999;48:50-8 pubmed
  43. Martin A, Maxson M, Leif J, Mordes J, Greiner D, Blankenhorn E. Diabetes-prone and diabetes-resistant BB rats share a common major diabetes susceptibility locus, iddm4: additional evidence for a "universal autoimmunity locus" on rat chromosome 4. Diabetes. 1999;48:2138-44 pubmed
    ..We propose that BB rat diabetes requires 1) class II RT1u (iddm2) for susceptibility, 2) additional loci for disease initiation and progression in response to perturbants, and 3) lyp for spontaneous disease...
  44. Kamiya H, Zhang W, Sima A. Degeneration of the Golgi and neuronal loss in dorsal root ganglia in diabetic BioBreeding/Worcester rats. Diabetologia. 2006;49:2763-74 pubmed
    ..The aim of this study was to evaluate the nature and extent of neuronal loss in dorsal root ganglia (DRG) in diabetic polyneuropathy...
  45. Sima A, Zhang W, Sugimoto K, Henry D, Li Z, Wahren J, et al. C-peptide prevents and improves chronic Type I diabetic polyneuropathy in the BB/Wor rat. Diabetologia. 2001;44:889-97 pubmed
    ..These studies were designed to test the preventive and interventional effects of C-peptide replacement on diabetic polyneuropathy in the Type I diabetic BB/Wor rat...
  46. Li Z, Zhang W, Sima A. C-peptide prevents hippocampal apoptosis in type 1 diabetes. Int J Exp Diabetes Res. 2002;3:241-5 pubmed
    ..Our data suggest that type 1 diabetes causes a duration-dependent programmed cell death of the hippocampus, which is partially prevented by C-peptide...
  47. Follak N, Kloting I, Merk H. Influence of diabetic metabolic state on fracture healing in spontaneously diabetic rats. Diabetes Metab Res Rev. 2005;21:288-96 pubmed
  48. Scott F, Cloutier H, Kleemann R, Wöerz Pagenstert U, Rowsell P, Modler H, et al. Potential mechanisms by which certain foods promote or inhibit the development of spontaneous diabetes in BB rats: dose, timing, early effect on islet area, and switch in infiltrate from Th1 to Th2 cells. Diabetes. 1997;46:589-98 pubmed
    ..Pancreatic inflammation in NIH-fed animals is a Th1-dependent phenomenon. The HC diet inhibited insulitis and was associated with a Th2 cytokine pattern in the pancreas, protecting diabetes-prone rats from developing diabetes. ..
  49. Beales P, Elliott R, Flohe S, Hill J, Kolb H, Pozzilli P, et al. A multi-centre, blinded international trial of the effect of A(1) and A(2) beta-casein variants on diabetes incidence in two rodent models of spontaneous Type I diabetes. Diabetologia. 2002;45:1240-6 pubmed
    ..Milk caseins are unlikely to be exclusive promoters of Type I diabetes, but could enhance the outcome of diabetes in some cases. Other diet components such as wheat could be more important promoters of Type I diabetes. ..
  50. Raz I, Eldor R, Naparstek Y. Immune modulation for prevention of type 1 diabetes mellitus. Trends Biotechnol. 2005;23:128-34 pubmed
    ..Here, we review the results of these trials. ..
  51. Rojas J, Sennoune S, Martinez G, Bakunts K, Meininger C, Wu G, et al. Plasmalemmal vacuolar H+-ATPase is decreased in microvascular endothelial cells from a diabetic model. J Cell Physiol. 2004;201:190-200 pubmed
    ..These novel observations suggest that the angiogenic abnormalities in diabetes involve a decrease in pmV-ATPase in microvascular endothelial cells. ..
  52. Li Q, Hwang Y, Ananthakrishnan R, Oates P, Guberski D, Ramasamy R. Polyol pathway and modulation of ischemia-reperfusion injury in Type 2 diabetic BBZ rat hearts. Cardiovasc Diabetol. 2008;7:33 pubmed publisher
  53. Okamoto M, Kahn C, Maron R, White M. Decreased autophosphorylation of EGF receptor in insulin-deficient diabetic rats. Am J Physiol. 1988;254:E429-34 pubmed
    ..In the case of EGF receptor, this is due in part to a decrease in receptor number and in part to a decrease in the specific activity of the kinase.(ABSTRACT TRUNCATED AT 250 WORDS)..
  54. Beleboni R, Guizzo R, Fontana A, Pizzo A, Carolino R, Gobbo Neto L, et al. Neurochemical characterization of a neuroprotective compound from Parawixia bistriata spider venom that inhibits synaptosomal uptake of GABA and glycine. Mol Pharmacol. 2006;69:1998-2006 pubmed
    ..These studies are of relevance by providing a better understanding of neurochemical mechanisms involved in brain function and for possible development of new neuropharmacological and therapeutic tools. ..
  55. Gandhi A, Beam H, O Connor J, Parsons J, Lin S. The effects of local insulin delivery on diabetic fracture healing. Bone. 2005;37:482-90 pubmed
  56. Lally F, Ratcliff H, Bone A. Apoptosis and disease progression in the spontaneously diabetic BB/S rat. Diabetologia. 2001;44:320-4 pubmed
    ..We have also detected differences in the levels of apoptosis between diabetic and non-diabetic animals and suggest that such differences could be an important determinant of disease progression in this animal model of Type I diabetes. ..
  57. Mei Q, Mundinger T, Lernmark K, Taborsky G. Increased galanin expression in the celiac ganglion of BB diabetic rats. Neuropeptides. 2006;40:1-10 pubmed
  58. Allen E, Luzina I, Huang S. IL-10 kinetics in thyroiditis-prone BB/Wor rats. Autoimmunity. 2000;32:229-40 pubmed
  59. Brown D, Welsh R, Like A. Infection of peripancreatic lymph nodes but not islets precedes Kilham rat virus-induced diabetes in BB/Wor rats. J Virol. 1993;67:5873-8 pubmed
    ..These findings suggest that widespread infection of peripancreatic and other lymphoid tissues but not pancreatic beta cells by KRV triggers autoimmune diabetes by perturbing the immune system of genetically predisposed BB/Wor rats...
  60. Beaudette Zlatanova B, Whalen B, Zipris D, Yagita H, Rozing J, Groen H, et al. Costimulation and autoimmune diabetes in BB rats. Am J Transplant. 2006;6:894-902 pubmed
  61. Al Zube L, Breitbart E, O Connor J, Parsons J, Bradica G, Hart C, et al. Recombinant human platelet-derived growth factor BB (rhPDGF-BB) and beta-tricalcium phosphate/collagen matrix enhance fracture healing in a diabetic rat model. J Orthop Res. 2009;27:1074-81 pubmed publisher
    ..Local application of rhPDGF-BB may be a new therapeutic approach to treat diabetes-impaired fracture healing...
  62. Hartoft Nielsen M, Rasmussen A, Bock T, Feldt Rasmussen U, Kaas A, Buschard K. Iodine and tri-iodo-thyronine reduce the incidence of type 1 diabetes mellitus in the autoimmune prone BB rats. Autoimmunity. 2009;42:131-8 pubmed publisher
    ..In Wistar rats T3 treatment increased the beta cell mass per bodyweight. The modulation of thyroid function during postnatal development may thus affect the precipitation of T1DM in genetically susceptible individuals...
  63. Uygur F, Oncul O, Evinc R, Diktaş H, Acar A, Ulkur E. Effects of three different topical antibacterial dressings on Acinetobacter baumannii-contaminated full-thickness burns in rats. Burns. 2009;35:270-3 pubmed publisher
    ..baumannii from the tissues more effectively...
  64. Like A, Guberski D, Butler L. Influence of environmental viral agents on frequency and tempo of diabetes mellitus in BB/Wor rats. Diabetes. 1991;40:259-62 pubmed
    ..These results suggest that the presence of environmental viral pathogens may act to inhibit effector cell function in lymphopenic DP rats while enhancing effector cell activity in nonlymphopenic DR rats...
  65. Augstein P, Wachlin G, Berg S, Bahr J, Salzsieder C, Hehmke B, et al. Surface and intracellular Fas expression associated with cytokine-induced apoptosis in rodent islet and insulinoma cells. J Mol Endocrinol. 2003;30:163-71 pubmed
    ..The underlying mechanisms, including possible interactions between these two sources of cellular Fas expression, need to be investigated in future studies...
  66. Ye X, Tang B, Ma Z, Zhou J, Myers L, Kang A, et al. The effects of interleukin-18 on rat articular chondrocytes: a study of mRNA expression and protein synthesis of proinflammatory substances. Clin Exp Immunol. 2007;149:553-60 pubmed
    ..These findings suggest further that IL-18 antagonists might prove beneficial as anti-inflammatory and chondroprotective agents in the treatment of arthritis, and that the development of such agents for human use is worth consideration...
  67. Haber B, Chin S, Chuang E, Buikhuisen W, Naji A, Taub R. High levels of glucose-6-phosphatase gene and protein expression reflect an adaptive response in proliferating liver and diabetes. J Clin Invest. 1995;95:832-41 pubmed
    ..The elevation of G6Pase expression in these conditions is indicative of its importance as a regulator of glucose homeostasis in normal and abnormal physiologic states...
  68. Li C, Shi Y, Wang W, Sardeli C, Kwon T, Thomsen K, et al. alpha-MSH prevents impairment in renal function and dysregulation of AQPs and Na-K-ATPase in rats with bilateral ureteral obstruction. Am J Physiol Renal Physiol. 2006;290:F384-96 pubmed
  69. Rodrigues L, Melo P, Silva M, Tavares M. Effects of postnatal exposure to methamphetamine on the development of the rat retina. Ann N Y Acad Sci. 2006;1074:604-19 pubmed
  70. Buschard K, Bock T, Pedersen C, Hansen S, Aaen K, Jørgensen M, et al. Neonatal treatment with beta-cell stimulatory agents reduces the incidence of diabetes in BB rats. Int J Exp Diabetes Res. 2000;1:1-8 pubmed
    ..The theory behind the study, that the treatment accelerates beta-cell maturation leading to increased immunological tolerance towards beta cells, is discussed...
  71. Ito I, Jarajapu Y, Guberski D, Grant M, Knot H. Myogenic tone and reactivity of rat ophthalmic artery in acute exposure to high glucose and in a type II diabetic model. Invest Ophthalmol Vis Sci. 2006;47:683-92 pubmed
    ..To evaluate the effect of acute exposure to high glucose on myogenic tone and reactivity of the rat ophthalmic artery and to compare the observations with that in ophthalmic artery from a diabetic rat model...
  72. Thomas V, Woda B, Handler E, Greiner D, Mordes J, Rossini A. Altered expression of diabetes in BB/Wor rats by exposure to viral pathogens. Diabetes. 1991;40:255-8 pubmed