inbred akr mice


Summary: An inbred strain of mouse that is widely used in IMMUNOLOGY studies and cancer research.

Top Publications

  1. Kosiewicz M, Nast C, Krishnan A, Rivera Nieves J, Moskaluk C, Matsumoto S, et al. Th1-type responses mediate spontaneous ileitis in a novel murine model of Crohn's disease. J Clin Invest. 2001;107:695-702 pubmed
    ..To our knowledge, these data provide the first direct evidence that Th1-producing T cells mediate intestinal inflammation in a spontaneous animal model of human Crohn's disease...
  2. Rivera Nieves J, Olson T, Bamias G, Bruce A, Solga M, Knight R, et al. L-selectin, alpha 4 beta 1, and alpha 4 beta 7 integrins participate in CD4+ T cell recruitment to chronically inflamed small intestine. J Immunol. 2005;174:2343-52 pubmed
    ..Thus, pathogenic CD4+ T cells not only use the physiologic alpha4beta7/MAdCAM-1 pathway, but alternatively engage alpha4beta1 and L-selectin to recirculate to the chronically inflamed small intestine...
  3. Datta R, deSchoolmeester M, Hedeler C, Paton N, Brass A, Else K. Identification of novel genes in intestinal tissue that are regulated after infection with an intestinal nematode parasite. Infect Immun. 2005;73:4025-33 pubmed
  4. Blackwell N, Else K. B cells and antibodies are required for resistance to the parasitic gastrointestinal nematode Trichuris muris. Infect Immun. 2001;69:3860-8 pubmed
    ..Our results as a whole describe the first detailed report of a critical role for B cells in resistance to an intestinal nematode...
  5. Kozaiwa K, Sugawara K, Smith M, Carl V, Yamschikov V, Belyea B, et al. Identification of a quantitative trait locus for ileitis in a spontaneous mouse model of Crohn's disease: SAMP1/YitFc. Gastroenterology. 2003;125:477-90 pubmed
    ..We performed a genetic analysis of a (B6 x SAMP1/Fc)F(2) cross to localize the genes regulating intestinal inflammation in this model...
  6. Olson T, Bamias G, Naganuma M, Rivera Nieves J, Burcin T, Ross W, et al. Expanded B cell population blocks regulatory T cells and exacerbates ileitis in a murine model of Crohn disease. J Clin Invest. 2004;114:389-98 pubmed
    ..SAMP1/YitFc B cells prevent alpha(E)beta(7)(+)CD4(+) T cells from suppressing effector T cell proliferation. We conclude that SAMP1/YitFc MLN B cells contribute to the development of SAMP1/YitFc ileitis...
  7. Artis D, Wang M, Keilbaugh S, He W, Brenes M, Swain G, et al. RELMbeta/FIZZ2 is a goblet cell-specific immune-effector molecule in the gastrointestinal tract. Proc Natl Acad Sci U S A. 2004;101:13596-600 pubmed
    ..Together, these results suggest that intestinal goblet cell-derived RELMbeta may be a novel Th2 cytokine-induced immune-effector molecule in resistance to GI nematode infection...
  8. Inoue T, Tsuzuki Y, Matsuzaki K, Matsunaga H, Miyazaki J, Hokari R, et al. Blockade of PSGL-1 attenuates CD14+ monocytic cell recruitment in intestinal mucosa and ameliorates ileitis in SAMP1/Yit mice. J Leukoc Biol. 2005;77:287-95 pubmed
  9. Zvonic S, Ptitsyn A, Conrad S, Scott L, Floyd Z, Kilroy G, et al. Characterization of peripheral circadian clocks in adipose tissues. Diabetes. 2006;55:962-70 pubmed

More Information

Publications104 found, 100 shown here

  1. Karp C, Grupe A, Schadt E, Ewart S, Keane Moore M, Cuomo P, et al. Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma. Nat Immunol. 2000;1:221-6 pubmed
    ..The role of complement in modulating susceptibility to asthma highlights the importance of immunoregulatory events at the interface of innate and adaptive immunity in disease pathogenesis...
  2. deSchoolmeester M, Little M, Rollins B, Else K. Absence of CC chemokine ligand 2 results in an altered Th1/Th2 cytokine balance and failure to expel Trichuris muris infection. J Immunol. 2003;170:4693-700 pubmed
    ..Elevated levels of IL-12 are produced by polarizing APCs, and the composition of the APC environment itself is perturbed, with reduced numbers of macrophages...
  3. Cliffe L, Humphreys N, Lane T, Potten C, Booth C, Grencis R. Accelerated intestinal epithelial cell turnover: a new mechanism of parasite expulsion. Science. 2005;308:1463-5 pubmed
    ..This host protective mechanism against intestinal pathogens has implications for our wider understanding of the multifunctional role played by intestinal epithelium in mucosal defense...
  4. Little M, Bell L, Cliffe L, Else K. The characterization of intraepithelial lymphocytes, lamina propria leukocytes, and isolated lymphoid follicles in the large intestine of mice infected with the intestinal nematode parasite Trichuris muris. J Immunol. 2005;175:6713-22 pubmed
    ..Furthermore, we demonstrate the organogenesis of these structures in response to T. muris infection...
  5. Owyang A, Zaph C, Wilson E, Guild K, McClanahan T, Miller H, et al. Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract. J Exp Med. 2006;203:843-9 pubmed
    ..Therefore, IL-25 is not only a critical mediator of type 2 immunity, but is also required for the regulation of inflammation in the gastrointestinal tract...
  6. Takeda T, Hosokawa M, Higuchi K. Senescence-accelerated mouse (SAM): a novel murine model of senescence. Exp Gerontol. 1997;32:105-9 pubmed
    ..The genetic background and significance of SAM development are discussed...
  7. Kulikov A, Zubkov E. Chronic thyroxine treatment activates the 5-HT2A serotonin receptor in the mouse brain. Neurosci Lett. 2007;416:307-9 pubmed
    ..0 mg/kg, i.p.) in AKR mice. The result indicates thyroid hormones involvement in 5-HT2A receptor regulation in adult brain. ..
  8. Kest B, Wilson S, Mogil J. Sex differences in supraspinal morphine analgesia are dependent on genotype. J Pharmacol Exp Ther. 1999;289:1370-5 pubmed
  9. Miranda S, Gentile T, Margni R. Enhancement of in vitro hsp72 expression by placental IL-6. Am J Reprod Immunol. 2001;46:358-65 pubmed
    ..A relationship with the increased synthesis of anti-paternal antigen asymmetric antibodies, previously observed during pregnancy, is discussed. ..
  10. Crabbe J, Metten P, Gallaher E, Belknap J. Genetic determinants of sensitivity to pentobarbital in inbred mice. Psychopharmacology (Berl). 2002;161:408-16 pubmed
    ..That is, genetically influenced sensitivity to PB is not monolithic, but is somewhat specific to the particular response variable studied, a result that also characterizes genetic control of responses to other drugs. ..
  11. Guda K, Marino J, Jung Y, Crary K, Dong M, Rosenberg D. Strain-specific homeostatic responses during early stages of Azoxymethane-induced colon tumorigenesis in mice. Int J Oncol. 2007;31:837-42 pubmed
  12. Varjas T, Nowrasteh G, Budán F, Nadasi E, Horvath G, Makai S, et al. Chemopreventive effect of Panax ginseng. Phytother Res. 2009;23:1399-403 pubmed publisher
    ..These results support the efficacy of ginseng-containing diets and dietary supplements in the prevention of cancerous diseases. ..
  13. Sakuma T, Ohtake M, Katsurayama Y, Jarukamjorn K, Nemoto N. Induction of CYP1A2 by phenobarbital in the livers of aryl hydrocarbon-responsive and -nonresponsive mice. Drug Metab Dispos. 1999;27:379-84 pubmed
    ..Cyclobarbital, pentobarbital, and secobarbital also induced CYP1A2 mRNA in primary culture hepatocytes from C57BL/6 mice. Barbital, in contrast, did not show any clear inductive effect on CYP1A2 mRNA. ..
  14. Li X, Huang C, Schofield B, Burks A, Bannon G, Kim K, et al. Strain-dependent induction of allergic sensitization caused by peanut allergen DNA immunization in mice. J Immunol. 1999;162:3045-52 pubmed
    ..Consequently, models for studying human allergen gene immunization require careful selection of suitable strains. In addition, this suggests that similar interindividual variation is likely in humans. ..
  15. James P, Nyby J. Testosterone rapidly affects the expression of copulatory behavior in house mice (Mus musculus). Physiol Behav. 2002;75:287-94 pubmed
    ..These experiments provide evidence that elevations in testosterone titers above baseline can, under certain conditions, rapidly alter the expression of male-typical behaviors. ..
  16. Mikhailova O, Gulyaeva L, Filipenko M, Kaledin V. Enhancer elements in the mouse CYP1A2 gene: a comparative sequencing among different inbred mouse strains. Mutat Res. 2007;632:99-103 pubmed
    ..The absence of mutation prescribing the phenotype in the CYP1A2 gene was found. The region studied seems to be a highly conserved in mice and not to be associated with interstrain differences in constitutive CYP1A2 enzyme activity. ..
  17. Thakur M, Sharma P. Binding of estrogen receptor alpha promoter to nuclear proteins of mouse cerebral cortex: effect of age, sex, and gonadal steroids. Biogerontology. 2008;9:467-78 pubmed publisher
    ..Thus, these findings demonstrate differential binding of nuclear proteins to mouse ERalpha promoter which may account for different functions of estrogen in the brain. ..
  18. Mogil J, Nessim L, Wilson S. Strain-dependent effects of supraspinal orphanin FQ/nociceptin on thermal nociceptive sensitivity in mice. Neurosci Lett. 1999;261:147-50 pubmed
    ..These data suggest that genetic variability among subject populations may underlie the inconsistent findings among researchers, and may in addition provide a promising avenue for future study of this novel neuromodulator. ..
  19. Witmer P, Doheny K, Adams M, Boehm C, Dizon J, Goldstein J, et al. The development of a highly informative mouse Simple Sequence Length Polymorphism (SSLP) marker set and construction of a mouse family tree using parsimony analysis. Genome Res. 2003;13:485-91 pubmed
    ..With this large data set, we sought to reconstruct a phylogenetic history of the laboratory mouse using Wagner parsimony analysis. Our results are largely congruent with the known history of inbred mouse strains. ..
  20. Ptitsyn A, Zvonic S, Gimble J. Permutation test for periodicity in short time series data. BMC Bioinformatics. 2006;7 Suppl 2:S10 pubmed
    ..The software is a set of C++ programs available from the authors on the open source basis. ..
  21. Richardson B, Ray D, Yung R. Murine models of lupus induced by hypomethylated T cells. Methods Mol Med. 2004;102:285-94 pubmed
    ..This chapter describes the protocols for inducing autoreactivity in murine T cells in vitro and using the cells to induce autoimmunity in vivo. ..
  22. Pathak C, Jaiswal Y, Vinayak M. Hypomodification of transfer RNA in cancer with respect to queuosine. RNA Biol. 2005;2:143-8 pubmed
    ..The activators NaPP and ATP enhance TGTase activity of normal and DLAT cancerous mouse, where as 7mG inhibits the TGTase activity. ..
  23. Lee K, Renne R, Harbo S, Clark M, Johnson R, Gideon K. 3-week inhalation exposure to cigarette smoke and/or lipopolysaccharide in AKR/J mice. Inhal Toxicol. 2007;19:23-35 pubmed
    ..A longer term study with interim assessments is needed to confirm that the subacute responses observed in the CS/LPS group will result in greater severity of COPD-related pulmonary lesions following prolonged exposures. ..
  24. Yao H, Edirisinghe I, Rajendrasozhan S, Yang S, Caito S, Adenuga D, et al. Cigarette smoke-mediated inflammatory and oxidative responses are strain-dependent in mice. Am J Physiol Lung Cell Mol Physiol. 2008;294:L1174-86 pubmed publisher
    ..Identification of sensitive and resistant mouse strains could be useful for studying the molecular mechanisms of effects of CS on inflammation and pharmacological interventional studies in CS-exposure mouse models. ..
  25. Takahashi R. [Anti-aging studies on the senescence accelerated mouse (SAM) strains]. Yakugaku Zasshi. 2010;130:11-8 pubmed
    ..Various lines of SAM (P1, P6, P8, P10 and R1) are now commercially available for research. In this review, I will briefly introduce various usages of SAM in anti-aging research. ..
  26. Fujimoto T, Kawashima H, Tanaka T, Hirose M, Toyama Sorimachi N, Matsuzawa Y, et al. CD44 binds a chondroitin sulfate proteoglycan, aggrecan. Int Immunol. 2001;13:359-66 pubmed
    ..These results suggest that aggrecan interacts with CD44 to mediate cell adhesion and to trigger oligomerization of CD44 molecules, which may lead to intracellular signaling. ..
  27. Aherrahrou Z, Doehring L, Kaczmarek P, Liptau H, Ehlers E, Pomarino A, et al. Ultrafine mapping of Dyscalc1 to an 80-kb chromosomal segment on chromosome 7 in mice susceptible for dystrophic calcification. Physiol Genomics. 2007;28:203-12 pubmed
    ..T153I changes might affect the biological function of EMP-3 gene product after injury. Using this combined approach, we ultrafine-mapped the Dyscalc1 locus to an 80-Kb region and identified EMP-3 as a new candidate gene for DCC. ..
  28. Maret S, Dorsaz S, Gurcel L, Pradervand S, Petit B, Pfister C, et al. Homer1a is a core brain molecular correlate of sleep loss. Proc Natl Acad Sci U S A. 2007;104:20090-5 pubmed
    ..The consistent activation of Homer1a suggests a role for sleep in intracellular calcium homeostasis for protecting and recovering from the neuronal activation imposed by wakefulness. ..
  29. Hadjipavlou Litina D, Geronikaki A. Thiazolyl and benzothiazolyl Schiff bases as novel possible lipoxygenase inhibitors and anti inflammatory agents. Synthesis and biological evaluation. Drug Des Discov. 1998;15:199-206 pubmed
    ..8% inhibition was observed). The results are discussed in terms of structural and physicochemical characteristics of the compounds. Comparing the results among all tests, the benzothiazolyl derivatives seem to be more potent. ..
  30. Canning J, Takai Y, Tilly J. Evidence for genetic modifiers of ovarian follicular endowment and development from studies of five inbred mouse strains. Endocrinology. 2003;144:9-12 pubmed
    ..These results indicate that genetic modifiers play a major role in follicle endowment, development and atresia in the mouse ovary. ..
  31. Katiyar D, Tiwari V, Tripathi R, Srivastava A, Chaturvedi V, Srivastava R, et al. Synthesis and antimycobacterial activity of 3,5-disubstituted thiadiazine thiones. Bioorg Med Chem. 2003;11:4369-75 pubmed
  32. Pozdeev N, Zinovev Y, Kozlov S, Ryabov N. Adjuvant effect of high-frequency hyperthermia of the abdominal cavity on the course of transplanted leukemia in AKR mice. Bull Exp Biol Med. 2004;137:490-2 pubmed
    ..A more pronounced antitumor effect was observed in animals exposed to hyperthermia. These data provide the basis for clinical use of hyperthermia of the abdominal cavity. ..
  33. Sommer A, Lerchl A. 50 Hz magnetic fields of 1 mT do not promote lymphoma development in AKR/J mice. Radiat Res. 2006;165:343-9 pubmed
    ..The resulting data do not support the hypothesis that exposure to sinusoidal 50 Hz magnetic fields is a significant risk factor for hematopoietic diseases, even at this relatively high exposure level. ..
  34. Naumenko V, Osipova D, Kostina E, Kulikov A. Utilization of a two-standard system in real-time PCR for quantification of gene expression in the brain. J Neurosci Methods. 2008;170:197-203 pubmed publisher
    ..We have also found that the genetically determined freezing reaction in mice is not connected with changes in Tph2 gene expression. ..
  35. Gerwin N, Gonzalo J, Lloyd C, Coyle A, Reiss Y, Banu N, et al. Prolonged eosinophil accumulation in allergic lung interstitium of ICAM-2 deficient mice results in extended hyperresponsiveness. Immunity. 1999;10:9-19 pubmed
    ..ICAM-2 is not essential for lymphocyte homing or the development of leukocytes, with the exception of megakaryocyte progenitors, which are significantly reduced. ..
  36. Sommer A, Streckert J, Bitz A, Hansen V, Lerchl A. No effects of GSM-modulated 900 MHz electromagnetic fields on survival rate and spontaneous development of lymphoma in female AKR/J mice. BMC Cancer. 2004;4:77 pubmed
    ..These data do not support the hypothesis that exposure to 900 MHz electromagnetic fields is a significant risk factor for developing lymphoma in a genetically predisposed species, even at a relatively high exposure level. ..
  37. Rich R, Green W. Apoptosis of epitope-specific antiretroviral cytotoxic T lymphocytes via Fas ligand-Fas interactions. Viral Immunol. 2006;19:424-33 pubmed
    ..H-2b cells to inhibit the antiviral CTL response. These results further characterize the nature of the interaction between veto cells and antiviral CTLs, and underscore the efficiency of veto cell-mediated inhibition of the CTL response...
  38. Eash J, Olsen A, Breur G, Gerrard D, Hannon K. FGFR1 inhibits skeletal muscle atrophy associated with hindlimb suspension. BMC Musculoskelet Disord. 2007;8:32 pubmed
  39. Aguilar Delfín I, Homer M, Wettstein P, Persing D. Innate resistance to Babesia infection is influenced by genetic background and gender. Infect Immun. 2001;69:7955-8 pubmed
    ..In comparison to their female counterparts, male mice of different genetic backgrounds showed increased resistance to the infection, indicating that the gender of the host may influence protection against babesiosis. ..
  40. Boisvert J, Edmondson S, Krummel M. Immunological synapse formation licenses CD40-CD40L accumulations at T-APC contact sites. J Immunol. 2004;173:3647-52 pubmed
    ..It may also serve as a site for these molecular aggregates to coassociate and/or internalize alongside other signaling receptors. ..
  41. Wilund K, Yu L, Xu F, Vega G, Grundy S, Cohen J, et al. No association between plasma levels of plant sterols and atherosclerosis in mice and men. Arterioscler Thromb Vasc Biol. 2004;24:2326-32 pubmed
    ..The results of this study do not support an association between elevated plasma levels of plant sterols and atherosclerosis. ..
  42. Relland L, Mishra M, Haribhai D, Edwards B, Ziegelbauer J, Williams C. Affinity-based selection of regulatory T cells occurs independent of agonist-mediated induction of Foxp3 expression. J Immunol. 2009;182:1341-50 pubmed
    ..The development of nT(reg) cells is therefore a multistep process in which ligand affinity, potency, and timing of presentation all play a role in determining cell fate. ..
  43. Leitenberg D, Boutin Y, Lu D, Bottomly K. Biochemical association of CD45 with the T cell receptor complex: regulation by CD45 isoform and during T cell activation. Immunity. 1999;10:701-11 pubmed
    ..These data suggest that T cell receptor signaling pathways may be modulated by altering access of CD45 to TCR-associated substrates involved in T cell activation. ..
  44. Haines J, Dunford R, Moody J, Ellender M, Cox R, Silver A. Loss of heterozygosity in spontaneous and X-ray-induced intestinal tumors arising in F1 hybrid min mice: evidence for sequential loss of APC(+) and Dpc4 in tumor development. Genes Chromosomes Cancer. 2000;28:387-94 pubmed
    ..Overall, our data indicates a significant role for Dpc4 mutation in intestinal tumor progression in the mouse and provides further evidence for the importance of interstitial chromosome losses in radiation tumorigenesis. ..
  45. Moss W, Irvine D, Davis M, Krummel M. Quantifying signaling-induced reorientation of T cell receptors during immunological synapse formation. Proc Natl Acad Sci U S A. 2002;99:15024-9 pubmed
    ..This method should permit the quantitation of other dynamic membrane events and the associated movement of cell-surface molecules. ..
  46. Harada T, Nagi Miura N, Adachi Y, Nakajima M, Yadomae T, Ohno N. Antibody to soluble 1,3/1,6-beta-D-glucan, SCG in sera of naive DBA/2 mice. Biol Pharm Bull. 2003;26:1225-8 pubmed
    ..These results suggested that DBA/1 and DBA/2 strains carry specific and unique immunological characteristics to branched 1,3-/1,6-beta-glucan. ..
  47. Shanti K, Kanungo M. Expression of muscle creatine kinase gene of mice and interaction of nuclear proteins with MEF-2, E boxes and A/T-rich elements during aging. Mol Biol Rep. 2004;31:43-50 pubmed
    ..Furthermore, the binding of these factors was found to decrease during aging which may contribute to the age-related decline in the expression of the MCK gene and activity of the heart. ..
  48. Sommer A, Bitz A, Streckert J, Hansen V, Lerchl A. Lymphoma development in mice chronically exposed to UMTS-modulated radiofrequency electromagnetic fields. Radiat Res. 2007;168:72-80 pubmed
    ..Therefore, the data show no negative effects from exposure and corroborate earlier findings in AKR/J mice exposed to GSM EMF (Sommer et al., BMC Cancer 4, 77-90, 2004). ..
  49. Persons D, Paulson R, Loyd M, Herley M, Bodner S, Bernstein A, et al. Fv2 encodes a truncated form of the Stk receptor tyrosine kinase. Nat Genet. 1999;23:159-65 pubmed
    ..We conclude that the Fv2 locus encodes Ron, and that a naturally expressed, truncated form of Stk confers susceptibility to Friend virus-induced erythroleukaemia...
  50. Baker P, Roopenian D. Genetic susceptibility to chronic periodontal disease. Microbes Infect. 2002;4:1157-67 pubmed
    ..Data from both clinical studies and studies using animal models are reviewed here. Also outlined are the genomic methods that are now available for identifying susceptibility and resistance loci...
  51. Parija T, Das B. Involvement of YY1 and its correlation with c-myc in NDEA induced hepatocarcinogenesis, its prevention by d-limonene. Mol Biol Rep. 2003;30:41-6 pubmed
  52. Tafti M, Petit B, Chollet D, Neidhart E, de Bilbao F, Kiss J, et al. Deficiency in short-chain fatty acid beta-oxidation affects theta oscillations during sleep. Nat Genet. 2003;34:320-5 pubmed
    ..Thus, an underappreciated metabolic pathway involving fatty acid beta-oxidation also regulates theta oscillations during sleep...
  53. Bazovkina D, Kulikova A, Kondaurova E, Popova N. [Selection for the predisposition to catalepsy enhances depressive-like traits in mice]. Genetika. 2005;41:1222-8 pubmed
    ..quot; The results indicate that genetically determined catalepsy is related to depressive-like characteristics of defensive behavior...
  54. Thakur M, Kumar R. 17Beta-estradiol modulates age-dependent binding of 40 kDa nuclear protein to androgen receptor promoter in mouse cerebral cortex. Biogerontology. 2007;8:575-82 pubmed
    ..Further characterization of this protein may help to explore the intricate mechanism that underlies the transcriptional regulation of androgen responsive genes during aging...
  55. Kang S, Lim H, Andrisani O, Broxmeyer H, Kim C. Vitamin A metabolites induce gut-homing FoxP3+ regulatory T cells. J Immunol. 2007;179:3724-33 pubmed
    ..Taken together, these results identify retinoids as positive regulatory factors for generation of gut-homing FoxP3+ T cells...
  56. Di Rosa F, Ramaswamy S, Ridge J, Matzinger P. On the lifespan of virgin T lymphocytes. J Immunol. 1999;163:1253-7 pubmed
    ..In contrast, mice that were primed to H-Y just after thymectomy continued to display immunological memory to H-Y for >1 year. These experiments show that primary immune responses disappear in the absence of a thymus...
  57. Goto K, Ohashi H, Takakura A, Itoh T. Current status of Helicobacter contamination of laboratory mice, rats, gerbils, and house musk shrews in Japan. Curr Microbiol. 2000;41:161-6 pubmed
    ..rodentium, and H. hepaticus/H. rodentium, respectively, and 1/14 gerbils infected with H. hepaticus. The results suggest the prevalence of these species of Helicobacter in mice, rats, gerbils, and house musk shrews in Japan...
  58. Franken P, Gip P, Hagiwara G, Ruby N, Heller H. Changes in brain glycogen after sleep deprivation vary with genotype. Am J Physiol Regul Integr Comp Physiol. 2003;285:R413-9 pubmed
    ..e., AK and D2, did not differ in their glycogen response. Thus glycogen content per se is an unlikely end point of sleep's functional role in brain energy homeostasis...
  59. Laouar Y, Crispe I, Flavell R. Overexpression of IL-7R alpha provides a competitive advantage during early T-cell development. Blood. 2004;103:1985-94 pubmed
    ..This advantage occurred at early stages of T-cell development. Our findings support the model that overexpression of growth factor receptors can contribute to proliferation and malignancy...
  60. Peters T, Sedlmeier R, Bussow H, Runkel F, Lüers G, Korthaus D, et al. Alopecia in a novel mouse model RCO3 is caused by mK6irs1 deficiency. J Invest Dermatol. 2003;121:674-80 pubmed
  61. Xu G, Zhao L. Characteristics of mRNA levels of hepatic key enzymes in cholesterol metabolism of genetically gallstone-susceptible mice. Chin Med J (Engl). 2004;117:1259-61 pubmed
  62. Wahl P, Wuthrich R. Role of the B7RP-1/ICOS pathway in renal tubular epithelial antigen presentation to CD4+ Th1 and Th2 cells. Nephron Exp Nephrol. 2004;98:e31-8 pubmed
    ..TECs normally do not express B7, the ligand for the classical T-cell costimulatory molecule CD28, but express B7RP-1, the ligand of the inducible costimulator (ICOS)...
  63. Butcher E, Rouse R, Coffman R, Nottenburg C, Hardy R, Weissman I. Surface phenotype of Peyer's patch germinal center cells: implications for the role of germinal centers in B cell differentiation. 1982. J Immunol. 2005;175:1363-72 pubmed
  64. Mani S, Thakur M. In the cerebral cortex of female and male mice, amyloid precursor protein (APP) promoter methylation is higher in females and differentially regulated by sex steroids. Brain Res. 2006;1067:43-7 pubmed
  65. Geronikaki A, Hadjipavlou Litina D, Tzaki M. Synthesis of some new thienyl and 1,3-thiazolyl-aminoketones with anti-inflammatory activity. Arzneimittelforschung. 2000;50:266-71 pubmed
    ..Both anti-inflammatory and antioxidant activities depended on some structural characteristics of the synthesised compounds...
  66. Yoshimura F, Wang T, Yu F, Kim H, Turner J. Mink cell focus-forming murine leukemia virus infection induces apoptosis of thymic lymphocytes. J Virol. 2000;74:8119-26 pubmed
    ..Our results suggest that apoptosis of thymic lymphocytes by virus infection is an important step in the early stages of MCF13 MLV tumorigenesis...
  67. Lenhard J, Croom D, Weiel J, Winegar D. HIV protease inhibitors stimulate hepatic triglyceride synthesis. Arterioscler Thromb Vasc Biol. 2000;20:2625-9 pubmed
    ..We propose that PI-associated hyperlipidemia is due to increased hepatic triglyceride synthesis and suggest that retinoids or meal restriction influences the effects of select PIs on lipid metabolism...
  68. Maekawa Y, Tsukumo S, Okada H, Kishihara K, Yasutomo K. Breakdown of peripheral T-cell tolerance by chronic interleukin-15 elevation. Transplantation. 2003;76:415-20 pubmed
    ..This new information may be of potential use in improving tumor vaccines to self-antigens and in ameliorating autoimmune or graft-versus-host disease...
  69. Tohjima E, Inoue D, Matsumoto T. [Animal models of accelerated senescence]. Nihon Rinsho. 2004;62 Suppl 2:768-71 pubmed
  70. Cutler G, Marshall L, Chin N, Baribault H, Kassner P. Significant gene content variation characterizes the genomes of inbred mouse strains. Genome Res. 2007;17:1743-54 pubmed
    ..Using a whole-genome association analysis, we demonstrate that complex multigenic phenotypes, such as food intake, can be associated with specific copy number changes...
  71. Verma N, Vinayak M. Semecarpus anacardium nut extract promotes the antioxidant defence system and inhibits anaerobic metabolism during development of lymphoma. Biosci Rep. 2009;29:151-64 pubmed publisher
    ..The aqueous extract was found to be more effective than doxorubicin, a classical anticarcinogenic drug, with respect to its action on antioxidant enzymes and LDH in the liver of mice with developing lymphomas...
  72. Yoshimura F, Wang T, Cankovic M. Sequences between the enhancer and promoter in the long terminal repeat affect murine leukemia virus pathogenicity and replication in the thymus. J Virol. 1999;73:4890-8 pubmed
  73. Hiraoka N, Petryniak B, Nakayama J, Tsuboi S, Suzuki M, Yeh J, et al. A novel, high endothelial venule-specific sulfotransferase expresses 6-sulfo sialyl Lewis(x), an L-selectin ligand displayed by CD34. Immunity. 1999;11:79-89 pubmed
    ..LSST therefore corresponds to an HEV-specific sulfotransferase that contributes to the biosynthesis of L-selectin ligands required for lymphocyte homing...
  74. Kuypers F, Watson G, Sage E, Walters M, Hamrick J, Hearst J. Stem cell transplantation with S-59 photochemically treated T-cell add-backs to establish allochimerism in murine thalassemia. Ann N Y Acad Sci. 2005;1054:214-22 pubmed
  75. Xin H, D Souza S, Jørgensen T, Vaughan A, Lengyel P, Kotzin B, et al. Increased expression of Ifi202, an IFN-activatable gene, in B6.Nba2 lupus susceptible mice inhibits p53-mediated apoptosis. J Immunol. 2006;176:5863-70 pubmed
    ..Taken together, our observations support the idea that increased expression of p202 in B6.Nba2 mice increases the susceptibility to develop lupus, in part, by inhibiting p53-mediated apoptosis...
  76. Keller J, Allen D, Davis C, Leamy L. 2,3,7,8-Tetrachlorodibenzo-p-dioxin affects fluctuating asymmetry of molar shape in mice, and an epistatic interaction of two genes for molar size. Heredity (Edinb). 2007;98:259-67 pubmed
    ..We concluded that although TCDD may be affecting the expression of some genes governing the development of molars in our population of mice, FA of molar size and shape is not a particularly sensitive indicator of this effect...
  77. Ghosh S, Thakur M. Interaction of estrogen receptor-alpha ligand binding domain with nuclear proteins of aging mouse brain. J Neurosci Res. 2009;87:2591-600 pubmed publisher
    ..Thus we report the identification and interaction of five nuclear proteins with mERalpha-LBD, indicating their role in estrogen signaling and brain functions during aging...
  78. Chaouat G, Petitbarat M, Dubanchet S, Rahmati M, Ledee N. Tolerance to the foetal allograft?. Am J Reprod Immunol. 2010;63:624-36 pubmed publisher
    ..We will then consider whether it applies to the foetal-maternal relationship and discuss the mechanisms involved in non-rejection of the foeto-placental unit...
  79. Wang C, Kang S, HogenEsch H, Love P, Kim C. Retinoic acid determines the precise tissue tropism of inflammatory Th17 cells in the intestine. J Immunol. 2010;184:5519-26 pubmed publisher
    ..The results indicate also that specific gut tropism of Th17 cells is determined by the combination of trafficking receptors regulated by the RA signal. ..
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