inbred aci rats


Summary: An inbred strain of rat that is widely used in BIOMEDICAL RESEARCH. Applications include the study of spontaneous NEOPLASMS; CHRONIC KIDNEY DISEASES, and CONGENITAL ABNORMALITIES.

Top Publications

  1. Dähn S, Schwalbach P, Maksan S, Wöhleke F, Benner A, Kuntz C. Influence of different gases used for laparoscopy (helium, carbon dioxide, room air, and xenon) on tumor volume, histomorphology, and leukocyte-tumor-endothelium interaction in intravital microscopy. Surg Endosc. 2005;19:65-70 pubmed
    ..This could be one explanation for the statistically significantly smaller tumor volume after laparoscopy with helium compared to laparoscopy with CO(2). ..
  2. Nair B, Majeska R, Rodan G. Rat alkaline phosphatase. I. Purification and characterization of the enzyme from osteosarcoma: generation of monoclonal and polyclonal antibodies. Arch Biochem Biophys. 1987;254:18-27 pubmed
    ..Two distinct monoclonal antibodies were each partly effective in immunoprecipitating AP when tested individually; however, together they precipitated over 90% of the AP activity. ..
  3. Brix G, Bellemann M, Haberkorn U. Biochemical modulation of the catabolism and tissue uptake of the anticancer drug 5-fluorouracil by 5-bromovinyluracil: assessment with metabolic (19)F MR imaging. Magn Reson Med. 1999;42:936-43 pubmed
    ..Magn Reson Med 42:936-943, 1999. ..
  4. Nakane Y, Adachi T, Voigt B, Yamasaki K, Kaji S, Inui T, et al. A novel mutation vf causing abnormal vacuoles in the central nervous system maps on rat chromosome 8. Exp Anim. 2002;51:149-55 pubmed
  5. Kuntz C, Kienle P, Schmeding M, Benner A, Autschbach F, Schwalbach P. Comparison of laparoscopic versus conventional technique in colonic and liver resection in a tumor-bearing small animal model. Surg Endosc. 2002;16:1175-81 pubmed
    ..The part of the thesis that states that fewer metastases should occur after laparoscopic oncological surgery cannot be confirmed in our study. ..
  6. Green M, Newell O, Aboyade Cole A, Darling Reed S, Thomas R. Diallyl sulfide induces the expression of estrogen metabolizing genes in the presence and/or absence of diethylstilbestrol in the breast of female ACI rats. Toxicol Lett. 2007;168:7-12 pubmed
    ..7-fold, respectively. Similar results were seen with SOD. These results suggests that DAS may prevent the formation of DES induced DNA damage by altering the expression of DES metabolizing genes. ..
  7. Chen Y, Zhao Y. Curative efficacy of penehyclidine combined with edaravone on acute cerebral infarction and their effects on serum TNF-? and NDS score in rats. Eur Rev Med Pharmacol Sci. 2018;22:223-228 pubmed publisher
  8. Noel J, Valente J, Ogle J, Cornelius J, Custer D, Li B, et al. Changes in bone marrow-derived myeloid cells from thermally injured rats reflect changes in the progenitor cell population. J Burn Care Rehabil. 2002;23:75-86 pubmed
    ..Cultured bone marrow from thermally injured animals produces myeloid cells with an altered phenotype. Similar changes in myelopoiesis may take place in vivo. ..
  9. Vecchini A, Ceccarelli V, Nocentini G, Riccardi C, Di Nardo P, Binaglia L. Dietary PUFA modulate the expression of proliferation and differentiation markers in Morris 3924A hepatoma cells. Biochim Biophys Acta. 2005;1737:138-44 pubmed
    ..This evidence implies that alpha-linolenic acid or one of its metabolic products induce albumin synthesis in hepatoma cells by modulating C/EBPalpha gene expression at post-transcriptional level. ..

More Information

Publications110 found, 100 shown here

  1. Vogl T, Qian J, Tran A, Oppermann E, Naguib N, Korkusuz H, et al. Study on the effect of chemoembolization combined with microwave ablation for the treatment of hepatocellular carcinoma in rats. Diagn Interv Radiol. 2017;23:150-155 pubmed publisher
    ..Tumor cubes were implanted into the liver of 30 male inbred ACI rats. Groups of 10 animals were treated at 13 days (TACE or microwave ablation) and 16 days (microwave ablation) ..
  2. Tanaka T, Nishikawa A, Mori Y, Morishita Y, Mori H. Inhibitory effects of non-steroidal anti-inflammatory drugs, piroxicam and indomethacin on 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in male ACI/N rats. Cancer Lett. 1989;48:177-82 pubmed
    ..05 and P less than 0.005). Rats given piroxicam or indomethacin alone had no neoplasms in the tongue. Thus, piroxicam and indomethacin significantly inhibited the development of tongue neoplasms in male ACI/N rats. ..
  3. Provoost A, Shiozawa M, van Dokkum R, Jacob H. Transfer of the Rf-1 region from FHH onto the ACI background increases susceptibility to renal impairment. Physiol Genomics. 2002;8:123-9 pubmed
    ..These findings indicate that the Rf-1B region of the FHH rat contains at least one gene affecting the susceptibility to progressive renal failure, especially in the presence of an increase in blood pressure. ..
  4. Dahmen U, Li J, Dirsch O, Gu Y, Polywka S, Doebel L, et al. Adoptive transfer of donor-derived immunity by liver transplantation: a potential avenue to prevent hepatitis B virus reinfection. J Viral Hepat. 2003;10:31-6 pubmed
    ..Further studies to augment the donor-derived immune response are warranted to ensure a therapeutic effect for the recipient at risk of reinfection. ..
  5. Brouha P, Perez Abadia G, Francois C, Laurentin Perez L, Gorantla V, Vossen M, et al. Lymphadenectomy prior to rat hind limb allotransplantation prevents graft-versus-host disease in chimeric hosts. Transpl Int. 2004;17:341-50 pubmed
    ..We conclude that mixed chimeric hosts are susceptible to GVHD due to the immunocompetent cell load provided by the LNs, not the BM, of hind limb allografts. ..
  6. Nagai M. [Effects of co-administration of CTLA4-Ig and ICOS-Ig for complex homologous transplantation in rats]. Hokkaido Igaku Zasshi. 2006;81:227-36 pubmed
  7. Lorentzen J, Andersson M, Issazadeh S, Dahlman I, Luthman H, Weissert R, et al. Genetic analysis of inflammation, cytokine mRNA expression and disease course of relapsing experimental autoimmune encephalomyelitis in DA rats. J Neuroimmunol. 1997;80:31-7 pubmed
    ..We conclude that the MHC haplotype of DA rats favors a prolonged proinflammatory autoimmune response associated with relapses, while the DA background intensifies inflammation correlating with a high incidence of relapsing disease. ..
  8. Niwa T, Yamashita S, Tsukamoto T, Kuramoto T, Nomoto T, Wakazono K, et al. Whole-genome analyses of loss of heterozygosity and methylation analysis of four tumor-suppressor genes in N-methyl-N'-nitro-N-nitrosoguanidine-induced rat stomach carcinomas. Cancer Sci. 2005;96:409-13 pubmed
    ..The search for other genes involved in these carcinomas needs to be continued...
  9. McKillop I, Vyas N, Schmidt C, Cahill P, Sitzmann J. Enhanced Gi-protein-mediated mitogenesis following chronic ethanol exposure in a rat model of experimental hepatocellular carcinoma. Hepatology. 1999;29:412-20 pubmed
    ..Furthermore, this effect may be caused by ethanol's direct up-regulation of the expression and activity of Gi-proteins in HCC. ..
  10. McKillop I, Schmidt C, Cahill P, Sitzmann J. Altered Gq/G11 guanine nucleotide regulatory protein expression in a rat model of hepatocellular carcinoma: role in mitogenesis. Hepatology. 1999;29:371-8 pubmed
    ..Furthermore, a PLC-linked MAPK cascade plays a significant role in the progression of the enhanced mitogenesis characteristic of HCC. ..
  11. Usuki T. [Presensitization of donor splenic dendritic cells with the CD40/CD40L blockade induce long-term graft acceptance]. Hokkaido Igaku Zasshi. 2002;77:571-9 pubmed
  12. Soukiasian H, Czer L, Wang H, Luthringer D, Wang C, Kamlot A, et al. Inhibition of graft coronary arteriosclerosis after heart transplantation. Am Surg. 2004;70:833-40 pubmed
    ..CsA prevents GCA in a dose-dependent fashion in the rat allograft. ..
  13. Broicher T, Seidenbecher T, Meuth P, Munsch T, Meuth S, Kanyshkova T, et al. T-current related effects of antiepileptic drugs and a Ca2+ channel antagonist on thalamic relay and local circuit interneurons in a rat model of absence epilepsy. Neuropharmacology. 2007;53:431-46 pubmed
    ..In summary, these results support the hypothesis of IT reduction as part of the mechanism of action of anti-absence drugs and demonstrate the ability of a specific IT antagonist to attenuate rhythmic burst firing and SWDs. ..
  14. Starlard Davenport A, Tryndyak V, James S, Karpf A, Latendresse J, Beland F, et al. Mechanisms of epigenetic silencing of the Rassf1a gene during estrogen-induced breast carcinogenesis in ACI rats. Carcinogenesis. 2010;31:376-81 pubmed publisher
    ..In conclusion, we demonstrate that epigenetic alterations precede formation of preneoplastic lesions indicating the significance of epigenetic events in induction of oncogenic pathways in early stages of carcinogenesis. ..
  15. Otsen M, den Bieman M, Kuiper M, Pravenec M, Kren V, Kurtz T, et al. Use of AFLP markers for gene mapping and QTL detection in the rat. Genomics. 1996;37:289-94 pubmed
    ..The current study illustrates the value of AFLP markers for the construction of linkage maps and the detection of quantitative trait loci. ..
  16. Li S, Thanikachalam M, Pang M, Kawaharada N, Aitouche A, Pham S. A clinically relevant CTLA4-Ig-based regimen induces chimerism and tolerance to heart grafts. Ann Thorac Surg. 2001;72:1306-10 pubmed
    ..A nontoxic CTLA4-Ig-based conditioning regimen effects mixed chimerism and donor-specific tolerance when heart and bone marrow are transplanted simultaneously. This regimen may have clinical application. ..
  17. Stepkowski S, Kao J, Wang M, Tejpal N, Podder H, Furian L, et al. The Mannich base NC1153 promotes long-term allograft survival and spares the recipient from multiple toxicities. J Immunol. 2005;175:4236-46 pubmed
    ..In contrast to CsA, NC1153 was not metabolized by cytochrome P450 3A4. Thus, NC1153 prolongs allograft survival without several toxic effects associated with current immunosuppressive drugs...
  18. Komori K, Hasegawa A, Kurihara K, Honda T, Yokozeki H, Masuda T, et al. Reduction of human T-cell leukemia virus type 1 (HTLV-1) proviral loads in rats orally infected with HTLV-1 by reimmunization with HTLV-1-infected cells. J Virol. 2006;80:7375-81 pubmed
  19. Dahmen U, Li J, Gu Y, Doebel L, Fan L, Polywka S, et al. The efficiency of humoral immune transfer depends on both the graft and the immunosuppressive treatment. Transpl Int. 2003;16:161-7 pubmed
    ..32%) and a longer titer persistence (up to 9 weeks) than in all other groups. Therefore, mainly liver and kidney graft recipients carry a risk, but also a chance of benefiting from the transfer of donor-derived immunity. ..
  20. Abe M, Yamashita S, Kuramoto T, Hirayama Y, Tsukamoto T, Ohta T, et al. Global expression analysis of N-methyl-N'-nitro-N-nitrosoguanidine-induced rat stomach carcinomas using oligonucleotide microarrays. Carcinogenesis. 2003;24:861-7 pubmed
  21. Yamashita K, Masunaga T, Yanagida N, Takehara M, Hashimoto T, Kobayashi T, et al. Long-term acceptance of rat cardiac allografts on the basis of adenovirus mediated CD40Ig plus CTLA4Ig gene therapies. Transplantation. 2003;76:1089-96 pubmed
    ..This strategy, however, was not enough to induce tolerance to skin grafts and to avoid chronic rejection, as shown in the liver-transplantation model. ..
  22. Li K, Todorovic R, Devanesan P, Higginbotham S, Köfeler H, Ramanathan R, et al. Metabolism and DNA binding studies of 4-hydroxyestradiol and estradiol-3,4-quinone in vitro and in female ACI rat mammary gland in vivo. Carcinogenesis. 2004;25:289-97 pubmed
    ..These adducts can generate the critical mutations that initiate cancer (Chakravarti et al., Oncogene, 2001, 20, 7945; Chakravarti et al., Proc. Am. Assoc. Cancer Res., 2003, 44, 180). ..
  23. Chen W, Langer R, Janczewska S, Furian L, Geary R, Qu X, et al. Methoxyethyl-modified intercellular adhesion molecule-1 antisense phosphorothiateoligonucleotides inhibit allograft rejection, ischemic-reperfusion injury, and cyclosporine-induced nephrotoxicity. Transplantation. 2005;79:401-8 pubmed
    ..ME/PS-modified ICAM-1 antisense oligo is very effective in inhibiting the ICAM-1-dependent mechanism of graft infiltration and tissue damage involved in allograft rejection, ischemic-reperfusion injury, and CsA-induced nephrotoxicity. ..
  24. Avsaroglu H, Sommer R, Hellebrekers L, Van Zutphen L, van Lith H. The effects of buprenorphine on behaviour in the ACI and BN rat inbred strains. Lab Anim. 2008;42:171-84 pubmed publisher
    ..The results of this study emphasize the possibility that strain-specific effects must be taken into account when using behavioural parameters for the assessment of the analgesic effects of buprenorphine in rats. ..
  25. Yolcu E, Gu X, Lacelle C, Zhao H, Bandura Morgan L, Askenasy N, et al. Induction of tolerance to cardiac allografts using donor splenocytes engineered to display on their surface an exogenous fas ligand protein. J Immunol. 2008;181:931-9 pubmed
  26. Renner P, Eggenhofer E, Rosenauer A, Popp F, Steinmann J, Slowik P, et al. Mesenchymal stem cells require a sufficient, ongoing immune response to exert their immunosuppressive function. Transplant Proc. 2009;41:2607-11 pubmed publisher
    ..For application of MSC in solid organ transplantation, it will be important to further describe this switch effect of MSC function. ..
  27. Shiraki K, Lu H, Ishimura Y, Kashiwabara S, Uesaka T, Katoh O, et al. Effects of weaning by surrogate mothers (ACI) on tumor development in SD rats treated with methylnitrosourea (MNU) and/or N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). Hiroshima J Med Sci. 2002;51:75-9 pubmed
    ..05). Similar results were obtained with MNU+MNNG and MNNG alone. The present experiment suggested that tumor induction might be effected by components of the mother's milk. ..
  28. Qian J, Vossoughi D, Woitaschek D, Oppermann E, Bechstein W, Li W, et al. Combined transarterial chemoembolization and arterial administration of Bletilla striata in treatment of liver tumor in rats. World J Gastroenterol. 2003;9:2676-80 pubmed
    ..Combination of TACE and arterial administration of Bletilla striata plus ligation of hepatic artery is more effective than TACE alone in the treatment of HCC in rats. ..
  29. Mitsuhashi N, Kearns Jonker M, Wu G, Bowdish M, Jin Y, Mencel R, et al. Identification, functional analysis and expression in a heterotopic heart transplant model of CXCL9 in the rat. Immunology. 2004;112:87-93 pubmed
    ..These findings indicate that rat CXCL9 has an in vivo role in the infiltration of CD4+ T cells in the transplanted graft. ..
  30. Mills L, Yu J, Xu X, Lee A, Zhu B. Naturally-occurring estradiol-17beta-fatty acid esters, but not estradiol-17beta, preferentially induce mammary tumorigenesis in female rats: implications for an important role in human breast cancer. Toxicol Appl Pharmacol. 2008;229:332-41 pubmed publisher
    ..This study establishes the endogenous estrogen-17beta-fatty acid esters as preferential inducers of mammary tumorigenesis. ..
  31. Lan F, Zeng D, Higuchi M, Higgins J, Strober S. Host conditioning with total lymphoid irradiation and antithymocyte globulin prevents graft-versus-host disease: the role of CD1-reactive natural killer T cells. Biol Blood Marrow Transplant. 2003;9:355-63 pubmed
    ..In conclusion, the TLI and ATG/anti-thymocyte serum conditioning regimen protects against GVHD in rats and mice, and regulatory natural killer T cells are required for protection. ..
  32. Li S, Salgar S, Thanikachalam M, Murdock A, Gammie J, Demetris A, et al. CTLA4-Ig-based conditioning regimen to induce tolerance to cardiac allografts. J Surg Res. 2006;136:238-46 pubmed
    ..Tolerant graft histology showed no obliterative arteriopathy or chronic rejection. The CTLA4-Ig based conditioning regimen with donor BMT produced mixed chimerism and induced donor- specific tolerance to cardiac allografts. ..
  33. Jablonski E, Mattocks M, Sokolov E, Koniaris L, Hughes F, Fausto N, et al. Decreased aquaporin expression leads to increased resistance to apoptosis in hepatocellular carcinoma. Cancer Lett. 2007;250:36-46 pubmed
    ..In contrast, hepatocytes rapidly responded to osmotic challenge through AQP-dependent water movement and underwent cell death following apoptotic stimulation. ..
  34. Drescher M, Khan K, Hatfield J, Shakir A, Drescher D. Immunohistochemical localization of adenylyl cyclase isoforms in the lateral wall of the rat cochlea. Brain Res Mol Brain Res. 2000;76:289-98 pubmed
  35. Murata S, Miniati D, Kown M, Koransky M, Lijkwan M, Balsam L, et al. Superoxide dismutase mimetic m40401 reduces ischemia-reperfusion injury and graft coronary artery disease in rodent cardiac allografts. Transplantation. 2004;78:1166-71 pubmed
    ..Furthermore, M40401 treatment decreases the development of oxidative stress-associated GCAD. This treatment strategy may have broad cardioprotective applications for all cardiac operations in addition to cardiac transplantation. ..
  36. Lijkwan M, Cooke D, Martens J, Kown M, Murata S, Peterson S, et al. Cyclosporine treatment of high dose and long duration reduces the severity of graft coronary artery disease in rodent cardiac allografts. J Heart Lung Transplant. 2005;24:439-45 pubmed
    ..However, increasing dose and duration of CsA did not completely eliminate the development of GCAD. Non-immunologic factors could contribute to this occurrence. ..
  37. Taki T, Masumoto H, Funamoto M, Minakata K, Yamazaki K, Ikeda T, et al. Fetal mesenchymal stem cells ameliorate acute lung injury in a rat cardiopulmonary bypass model. J Thorac Cardiovasc Surg. 2017;153:726-734 pubmed publisher
    ..Allogeneic transplantation of FM-MSCs may be a potent strategy to prevent CPB-induced systemic inflammation and acute lung injury by suppressing the expression of inflammatory cytokines and promoting protective factors in the lung. ..
  38. Schwarz N, Kalff J, Türler A, Speidel N, Grandis J, Billiar T, et al. Selective jejunal manipulation causes postoperative pan-enteric inflammation and dysmotility. Gastroenterology. 2004;126:159-69 pubmed
    ..Selective small bowel manipulation leads to a molecular, cellular, and functional pan-enteric "field effect" phenomenon in the unmanipulated gastric and colonic muscularis. ..
  39. Sileri P, Sica G, Gentileschi P, Venza M, Manzelli A, Palmieri G, et al. Ischemic preconditioning protects intestine from prolonged ischemia. Transplant Proc. 2004;36:283-5 pubmed
    ..The findings from this study confirm that IP preconditioning attenuates morphological alterations that are invariably present after prolonged ischemia and reperfusion. ..
  40. Redaelli C, Wagner M, Günter Duwe D, Tian Y, Stahel P, Mazzucchelli L, et al. 1alpha,25-dihydroxyvitamin D3 shows strong and additive immunomodulatory effects with cyclosporine A in rat renal allotransplants. Kidney Int. 2002;61:288-96 pubmed
    ..The present study investigated the effect of 1alpha,25-dihydroxycholecalciferol (1,25DHC) on vascularized renal allografts in rats...
  41. Iwasaki N, Gohda T, Yoshioka C, Murakami M, Inobe M, Minami A, et al. Feasibility of immunosuppression in composite tissue allografts by systemic administration of CTLA4Ig. Transplantation. 2002;73:334-40 pubmed
    ..Using a rat hind limb allograft model, we examined the efficacy of CTLA4Ig against the allograft rejection of composite tissue...
  42. Li J, Dahmen U, Dirsch O, Gu Y, Polywka S, Fiedler M, et al. The potential role of bone marrow transplantation in augmenting donor-derived immunity to hepatitis B after rat liver transplantation. Liver Transpl. 2002;8:397-404 pubmed
    ..Improvement of the effect of postoperative vaccination possibly can be achieved by optimizing the immunization protocol...
  43. Chang G, Liu T, Feng S, Bedolli M, O Rourke R, Schmidt G, et al. Targeted gene therapy with CD40Ig to induce long-term acceptance of liver allografts. Surgery. 2002;132:149-56 pubmed
    ..The purpose of this study was to modulate the immune response of rat liver transplant recipients by adenovirus-mediated gene transfer of CD40Ig, a secretable fusion protein designed to block the CD40-CD154 T-cell costimulation pathway...
  44. Maluf D, Fisher R, Riley R, Wallace M, Tawes J, Bu D, et al. Immunobiology and long-term graft function in a transplant heterotopic renal rat model. Clin Transplant. 2002;16 Suppl 7:6-14 pubmed
    ..In the present study, we investigated the immunobiology of grafts in a long-term follow-up (>350 d)...
  45. Nagata H, Ito M, Cai J, Edge A, Platt J, Fox I. Treatment of cirrhosis and liver failure in rats by hepatocyte xenotransplantation. Gastroenterology. 2003;124:422-31 pubmed
    ..The use of porcine hepatocytes might address this problem; however, xenogeneic hepatocytes are thought to be functionally incompatible across species and susceptible to irreversible rejection...
  46. Semiltova N, Shen X, Fishbein M, Gao F, Slomowitz S, Jiao Q, et al. Posttransplant administration of allochimeric major histocompatibility complex class-I-molecules induces true transplantation tolerance. Transplantation. 2003;75:550-3 pubmed
    ..Here, we investigated the ability of posttransplant allochimeric administration to induce tolerance and concomitantly inhibit chronic rejection...
  47. Tanaka T, Mori H, Takahashi M, Williams G. DNA content of hyperplastic and neoplastic acinar cell lesions in rat and human pancreas. J Exp Pathol. 1984;1:315-26 pubmed
    ..These findings demonstrate that acinar cell hyperplastic lesions in rats and humans have an altered genetic complement and suggest that they probably are precursor lesions for acinar cell neoplasms...
  48. Waldrop S, Alexander D, Lowry R, Winn K, Pearson T, Constantinidis I. Analysis of allogeneic and syngeneic rat heart transplants using 23Na magnetic resonance spectroscopy. Biochem Biophys Res Commun. 1996;223:379-83 pubmed
    ..23Na MRS showed a steady elevation in signal in the 3 days prior to rejection and a sharp rise after rejection. 23Na MRS accurately identified full rejection and was also sensitive to the rejection process...
  49. Stoll M, Kwitek Black A, Cowley A, Harris E, Harrap S, Krieger J, et al. New target regions for human hypertension via comparative genomics. Genome Res. 2000;10:473-82 pubmed
  50. Haberkorn U, Altmann A, Kamencic H, Morr I, Traut U, Henze M, et al. Glucose transport and apoptosis after gene therapy with HSV thymidine kinase. Eur J Nucl Med. 2001;28:1690-6 pubmed
    ..Therefore, enhanced glucose transport seems to represent a stress reaction of tumour cells dedicated for the prevention of cell death...
  51. Shull J, Pennington K, Reindl T, Snyder M, Strecker T, Spady T, et al. Susceptibility to estrogen-induced mammary cancer segregates as an incompletely dominant phenotype in reciprocal crosses between the ACI and Copenhagen rat strains. Endocrinology. 2001;142:5124-30 pubmed
  52. Iesalnieks I, Tange S, Scherer M, Graeb C, Frank E, Jauch K, et al. Paclitaxel promotes liver graft survival in rats and inhibits hepatocellular carcinoma growth in vitro and is a potentially useful drug for transplant patients with liver cancer. Transplant Proc. 2002;34:2316-7 pubmed
  53. Sileri P, Sica G, Gentileschi P, Venza M, Benavoli D, Jarzembowski T, et al. Melatonin reduces bacterial translocation after intestinal ischemia-reperfusion injury. Transplant Proc. 2004;36:2944-6 pubmed
    ..Accordingly, a single injection of exogenous melatonin significantly reduced the intestinal IR injury and prevented bacterial translocation...
  54. Kobayashi M, Okada T, Murakami T, Ozawa K, Kobayashi E, Morita T. Tissue-targeted in vivo gene transfer coupled with histone deacetylase inhibitor depsipeptide (FK228) enhances adenoviral infection in rat renal cancer allograft model systems. Urology. 2007;70:1230-6 pubmed
    ..To overcome this disadvantage, we performed in vivo local gene transfer, in combination with the histone deacetylase inhibitor, depsipeptide (FK228), in a rat renal cancer model...
  55. Mesia Vela S, Sanchez R, Roberts K, Reuhl K, Conney A, Kauffman F. Dietary clofibrate stimulates the formation and size of estradiol-induced breast tumors in female August-Copenhagen Irish (ACI) rats. Toxicology. 2008;246:63-72 pubmed publisher
  56. Brilliant K, Mills D, Callanan H, Hixson D. Engraftment of syngeneic and allogeneic endothelial cells, hepatocytes and cholangiocytes into partially hepatectomized rats previously treated with mitomycin C. Transplantation. 2009;88:486-95 pubmed publisher
    ..Shortcomings are length of protocol and carcinogenicity of retrorsine...
  57. Drescher M, Barretto R, Chaturvedi D, Beisel K, Hatfield J, Khan K, et al. Expression of subunits for the cAMP-sensitive 'olfactory' cyclic nucleotide-gated ion channel in the cochlea: implications for signal transduction. Brain Res Mol Brain Res. 2002;98:1-14 pubmed
    ..3. Further, the localization of CNG2 and CNG5 immunoreactivity to hair cell stereocilia suggests a role for cAMP-sensitive CNG channels in hair cell signal transduction...
  58. Inuzuka S, Koga S, Nishikido M, Miyata Y, Kanda S, Shimokawa I, et al. Donor-specific blood transfusion prolongs cardiac allograft survival in rats by low nitric oxide production and elevated serum levels of prostaglandin E(2). Immunol Lett. 2002;83:119-24 pubmed
    ..Our results suggest that DST prolongs graft survival by enhanced production of PGE(2) with a resultant suppression of immune activation. In addition, DST-induced prolongation of graft survival may be partially mediated by NO suppression...
  59. Reyes N, Iatropoulos M, Mittelman A, Geliebter J. Microarray analysis of diet-induced alterations in gene expression in the ACI rat prostate. Eur J Cancer Prev. 2002;11 Suppl 2:S37-42 pubmed
  60. Tomaru U, Ikeda H, Jiang X, Ohya O, Yoshiki T. Provirus expansion and deregulation of apoptosis-related genes in the spinal cord of a rat model for human T-lymphocyte virus type I-associated myeloneuropathy. J Neurovirol. 2003;9:530-8 pubmed
  61. Mitsuoka N, Iwagaki H, Ozaki M, Sheng S, Sadamori H, Matsukawa H, et al. The impact of portal infusion with donor-derived bone marrow cells and intracellular cytokine expression of graft-infiltrating lymphocytes on the graft survival in rat small bowel transplant model. Transpl Immunol. 2004;13:155-60 pubmed
  62. Karpova A, Bikbaev A, Coenen A, van Luijtelaar G. Morphometric Golgi study of cortical locations in WAG/Rij rats: the cortical focus theory. Neurosci Res. 2005;51:119-28 pubmed
    ..Finally, these results are in line with the cortical focus theory of absence epilepsy...
  63. Ouyang J, Xu D, Zhang X, Qi S, Ma A, Jiang W, et al. Effect of a novel inducible nitric oxide synthase inhibitor in prevention of rat chronic aortic rejections. Transplantation. 2005;79:1386-92 pubmed
    ..In this study, the authors evaluated the effect of FR260330 in prevention of chronic rejection in a model of rat aortic allografts...
  64. Rousvoal G, Si M, Lau M, Zhang S, Berry G, Flores M, et al. Janus kinase 3 inhibition with CP-690,550 prevents allograft vasculopathy. Transpl Int. 2006;19:1014-21 pubmed
    ..These results are the first to show that JAK3 blockade by CP-690,550 effectively prevents allograft vasculopathy in this rat model of aorta transplantation...
  65. Gordon C, Matthews M, Lefebvre D, Strande L, Marra S, Guglielmi M, et al. A new modified technique for heterotopic femoral heart transplantation in rats. J Surg Res. 2007;139:157-63 pubmed
    ..Rao and Lisitza developed a femoral heart accessory transplant model in 1985. Our goal was to improve this femoral model for the study of cardiac transplantation between both syngeneic and allogeneic rats...
  66. Sudo T, Ito H, Hayashi H, Nagamura Y, Toga K, Yamada Y. Genetic strain differences in platelet aggregation and thrombus formation of laboratory rats. Thromb Haemost. 2007;97:665-72 pubmed
    ..The present study demonstrates that there are considerable strain differences in platelet aggregation among laboratory rats, which reflect thrombus formation...
  67. Alyautdin R, Tezikov E, Ramge P, Kharkevich D, Begley D, Kreuter J. Significant entry of tubocurarine into the brain of rats by adsorption to polysorbate 80-coated polybutylcyanoacrylate nanoparticles: an in situ brain perfusion study. J Microencapsul. 1998;15:67-74 pubmed
    ..Thus only the loading of tubocurarine onto the polysorbate 80-coated nanoparticles appears to enable the transport of this quaternary ammonium compound through the blood-brain barrier...
  68. Hosaka S, Kawa S, Aoki Y, Tanaka E, Yoshizawa K, Karasawa Y, et al. Hepatocarcinogenesis inhibition by caffeine in ACI rats treated with 2-acetylaminofluorene. Food Chem Toxicol. 2001;39:557-61 pubmed
    ..Dose-dependent inhibition of hepatocarcinogenesis by caffeine was also seen. The inhibitory effect of caffeine on hepatocarcinogenesis in rats was found when caffeine was administered during the initiation phase...
  69. Midha R, Ramakrishna V, Munro C, Matsuyama T, Gorczynski R. Detection of host and donor cells in sex-mismatched rat nerve allografts using RT-PCR for a Y chromosome (H-Y) marker. J Peripher Nerv Syst. 2000;5:140-6 pubmed
    ..These data suggest that reverse RT-PCR analysis for a Y chromosome gene product can be a valuable tool to assess the origin of viable cells in sex-mismatched nerve allotransplantation tissue...
  70. Krix M, Kiessling F, Farhan N, Schmidt K, Hoffend J, Delorme S. A multivessel model describing replenishment kinetics of ultrasound contrast agent for quantification of tissue perfusion. Ultrasound Med Biol. 2003;29:1421-30 pubmed
    ..In conclusion, a more valid, detailed and accurate calculation of perfusion parameters, especially of tumors, can be derived in vivo with the new multivessel model of intermittent sonography...
  71. Yamasaki T, Onodera H, Takahashi R, Imamura M. Islet film cures diabetes. J Artif Organs. 2004;7:37-40 pubmed
    ..This novel method requires little skill and no special instruments. This islet film approach may prove suitable for simple islet transplantation in clinical cases...
  72. Liu D, Shen X, Fang Z, Gao F, Semiletova N, Cao M, et al. Identification of early tolerance regulator genes induced by allochimeric therapy using microarray-based genomewide scan. Transplant Proc. 2005;37:1942-3 pubmed
    ..Following array data normalization and modeling, we compared the above two treatment groups and identified a total of 250 tolerance regulator genes induced by allochimeric molecules only...
  73. Thomas B, Aramant R, Sadda S, Seiler M. Light response differences in the superior colliculus of albino and pigmented rats. Neurosci Lett. 2005;385:143-7 pubmed
    ..This can be attributed to the transmission of rod-driven responses. The differences observed in the light response characteristics of albino rats may be indicative of their visual abnormalities...
  74. Zou Y, Hernandez F, Burgos E, Martinez L, Gonzalez Reyes S, Fernandez Dumont V, et al. Organ changes and bacterial translocation in a rat model of chronic rejection after small bowel transplantation. Transplant Proc. 2006;38:1569-72 pubmed
    ..Rejection after small bowel transplantation (SBTx) may allow bacterial translocation damaging the liver and lungs. This study investigated these issues in a rat model of chronic rejection...
  75. Nakanishi T, Morokata T, Kubo K, Umeno H, Eikyu Y, Kozuki Y, et al. Effect of the inosine 5'-monophosphate dehydrogenase inhibitor BMS-566419 on rat cardiac allograft rejection. Int Immunopharmacol. 2010;10:91-7 pubmed publisher
    ..These results suggest that BMS-566419 and other chemically synthesized IMPDH inhibitors have beneficial pharmacological effects similar to those of MMF, and are potential pharmaceutical candidates in transplant indications...
  76. Hofkamp L, Bradley S, Geliebter J, Timms B. Atypical fetal prostate development is associated with ipsilateral hypoplasia of the wolffian ducts in the ACI rat. Anat Rec (Hoboken). 2010;293:747-53 pubmed publisher
    ..Alterations to normal prenatal development of the male accessory sex organs can have important consequences for the growth and morphology of the adult gland...
  77. Singer J, Mhoyan A, Fishbein M, Shen X, Gao F, Zhao D, et al. Allochimeric class I MHC molecules prevent chronic rejection and attenuate alloantibody responses. Transplantation. 2001;72:1408-16 pubmed
    ..Aa) sequences in the alpha1-helical region induces donor-specific tolerance to cardiac allografts in rat recipients. This study examined the effect of allochimeric molecules on the development of chronic rejection...
  78. Turan V, Sanchez R, Li J, Li S, Reuhl K, Thomas P, et al. The effects of steroidal estrogens in ACI rat mammary carcinogenesis: 17beta-estradiol, 2-hydroxyestradiol, 4-hydroxyestradiol, 16alpha-hydroxyestradiol, and 4-hydroxyestrone. J Endocrinol. 2004;183:91-9 pubmed
    ..In summary, we observed a dose-dependent induction of mammary tumors in female ACI rats treated continuously with E2; however, under these conditions 2-OH E2, 4-OH E2, 16alpha-OH E2, and 4-OH E1 were inactive in inducing mammary tumors...
  79. Koksoy S, Elpek K, Yolcu E, Shirwan H. Tolerance to rat heart grafts induced by intrathymic immunomodulation is mediated by indirect recognition primed CD4+CD25+ Treg cells. Transplantation. 2005;79:1492-7 pubmed
    ..The purpose of this study was to characterize these regulatory cells with particular emphasis on CD4+CD25+ Treg cells...
  80. Weroha S, Li S, Tawfik O, Li J. Overexpression of cyclins D1 and D3 during estrogen-induced breast oncogenesis in female ACI rats. Carcinogenesis. 2006;27:491-8 pubmed
  81. Moadsiri A, Polchert D, Genrich K, Napoles P, Reina E, Turian J, et al. Mesenchymal stem cells enhance xenochimerism in NK-depleted hosts. Surgery. 2006;140:315-21 pubmed
    ..We tested whether xenogeneic bone marrow grafts, engineered with mesenchymal stem cells (MSCs), might provide a new nontoxic approach to enhance xenogeneic engraftment...
  82. Imaoka T, Nishimura M, Kakinuma S, Hatano Y, Ohmachi Y, Yoshinaga S, et al. High relative biologic effectiveness of carbon ion radiation on induction of rat mammary carcinoma and its lack of H-ras and Tp53 mutations. Int J Radiat Oncol Biol Phys. 2007;69:194-203 pubmed
    ..We undertook the present study to clarify the RBE of therapeutic carbon ion radiation and molecular changes that occur in the rat mammary cancer model...
  83. van Dokkum R, Jacob H, Provoost A. Difference in susceptibility of developing renal damage in normotensive fawn-hooded (FHL) and August x Copenhagen Irish (ACI) rats after N(omega)-nitro-L-arginine methyl ester induced hypertension. Am J Hypertens. 1997;10:1109-16 pubmed
    ..We conclude that there is an interaction between blood pressure and the genetic susceptibility to renal disease in the FHL rat...
  84. Foster R, Ascher N, McCalmont T, Neipp M, Anthony J, Mathes S. Mixed allogeneic chimerism as a reliable model for composite tissue allograft tolerance induction across major and minor histocompatibility barriers. Transplantation. 2001;72:791-7 pubmed
    ..The purpose of this study was to develop a model for reliable CTA tolerance induction in the adult rat across a major MHC mismatch without the need for long-term immunosuppression...
  85. Hehr T, Budach W, Lamprecht U, Belka C, Classen J, Trübenbach J, et al. Experimental thermoradiotherapy in malignant hepatocellular carcinoma. Int J Radiat Oncol Biol Phys. 2003;55:1374-80 pubmed
    ..We therefore developed an experimental model for combined radiotherapy and hyperthermia of the liver in transplantable rat Morris hepatoma 3924A...
  86. Gohda T, Iwasaki N, Yoshioka C, Minami A. Effect of single-dose administration of FK-506 on allogeneic limb transplantation in rats: is there an optimal timing of its administration?. Plast Reconstr Surg. 2003;111:1653-8 pubmed
    ..For prolonged survival of a grafted limb, a single-dose administration of FK-506 is more effective at 24 to 48 hours after transplantation...
  87. Inderbitzin D, Stoupis C, Sidler D, Gass M, Candinas D. Abdominal magnetic resonance imaging in small rodents using a clinical 1.5 T MR scanner. Methods. 2007;43:46-53 pubmed
    ..Experimental MRI is crucial for non-invasive monitoring of a broad range of biological processes and will further our general understanding of physiology and disease...
  88. Van Rijn C, Gaetani S, Santolini I, Badura A, Gabova A, Fu J, et al. WAG/Rij rats show a reduced expression of CB? receptors in thalamic nuclei and respond to the CB? receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia. 2010;51:1511-21 pubmed publisher
    ..We used WAG/Rij rats to examine whether absence seizures are associated with changes in the expression of type-1 cannabinoid (CB?) receptors...
  89. Sang J, Lim Y, Panzica M, Finch P, Thompson N. TA1, a highly conserved oncofetal complementary DNA from rat hepatoma, encodes an integral membrane protein associated with liver development, carcinogenesis, and cell activation. Cancer Res. 1995;55:1152-9 pubmed
    ..2-kilobase transcript. TA1 expression was closely associated with progression in this tumor model and suggests this molecule, originally linked to cell activation, also plays a role in the malignant phenotype...
  90. Brix G, Bellemann M, Haberkorn U, Gerlach L, Lorenz W. Assessment of the biodistribution and metabolism of 5-fluorouracil as monitored by 18F PET and 19F MRI: a comparative animal study. Nucl Med Biol. 1996;23:897-906 pubmed
    ..The MR images, however, yielded the additional information that 5-FU is converted to FBAL only in the liver and not in the hepatomas...
  91. Drescher M, Khan K, Beisel K, Karadaghy A, Hatfield J, Kim S, et al. Expression of adenylyl cyclase type I in cochlear inner hair cells. Brain Res Mol Brain Res. 1997;45:325-30 pubmed
  92. Jones N, Hebebrand D, Buttemeyer R, Zhao M, Benhaim P, Rao U. Comparison of long-term immunosuppression for limb transplantation using cyclosporine, tacrolimus, and mycophenolate mofetil: implications for clinical composite tissue transplantation. Plast Reconstr Surg. 2001;107:777-84 pubmed
    ..Combination immunosuppression with FK-506 and RS-61443, therefore, may be required to allow composite tissue transplantation to become a predictable clinical reality in the future...