inbred a mice


Summary: An inbred strain of mouse that is widely used in IMMUNOLOGY studies and cancer research.

Top Publications

  1. Losick V, Stephan K, Smirnova I, Isberg R, Poltorak A. A hemidominant Naip5 allele in mouse strain MOLF/Ei-derived macrophages restricts Legionella pneumophila intracellular growth. Infect Immun. 2009;77:196-204 pubmed publisher
    ..Therefore, one of these mutations may be critical for restriction of L. pneumophila intracellular growth, and this parallels results found with human NLR variants with defects in the innate immune response...
  2. Rennie C, Noyes H, Kemp S, Hulme H, Brass A, Hoyle D. Strong position-dependent effects of sequence mismatches on signal ratios measured using long oligonucleotide microarrays. BMC Genomics. 2008;9:317 pubmed publisher
    ..Sequence mismatches between probe and target strands are known to affect the stability of the probe-target duplex, and hence the strength of the observed signals from microarrays...
  3. Valdar W, Flint J, Mott R. Simulating the collaborative cross: power of quantitative trait loci detection and mapping resolution in large sets of recombinant inbred strains of mice. Genetics. 2006;172:1783-97 pubmed
    ..However, even with a very large panel of RILs, mapping resolution may not be sufficient to identify single genes unambiguously. Our results are generally applicable to the design of RILs in other species...
  4. Nadler J, Zou F, Huang H, Moy S, Lauder J, Crawley J, et al. Large-scale gene expression differences across brain regions and inbred strains correlate with a behavioral phenotype. Genetics. 2006;174:1229-36 pubmed
    ..Thus we can begin to identify expression profiles contributing to behavioral phenotypes through variation in gene expression...
  5. Zhang Y, Maksakova I, Gagnier L, van de Lagemaat L, Mager D. Genome-wide assessments reveal extremely high levels of polymorphism of two active families of mouse endogenous retroviral elements. PLoS Genet. 2008;4:e1000007 pubmed publisher
    ..These extreme levels of polymorphism suggest that ERV insertions play a significant role in genetic drift of mouse lines...
  6. Nielsen K, Cox G, Wang P, Toffaletti D, Perfect J, Heitman J. Sexual cycle of Cryptococcus neoformans var. grubii and virulence of congenic a and alpha isolates. Infect Immun. 2003;71:4831-41 pubmed
    ..Our studies highlight a role for sexual recombination in the evolution of a human fungal pathogen and provide a robust genetic platform to establish the molecular determinants of virulence...
  7. Min oo G, Fortin A, Tam M, Nantel A, Stevenson M, Gros P. Pyruvate kinase deficiency in mice protects against malaria. Nat Genet. 2003;35:357-62 pubmed
    ..These results suggest that pyruvate kinase deficiency may similarly protect humans against malaria...
  8. Molofsky A, Shetron Rama L, Swanson M. Components of the Legionella pneumophila flagellar regulon contribute to multiple virulence traits, including lysosome avoidance and macrophage death. Infect Immun. 2005;73:5720-34 pubmed
    ..Thus, the flagellar regulon equips the aquatic pathogen L. pneumophila to coordinate motility with multiple traits vital to virulence...
  9. Laguna R, Creasey E, Li Z, Valtz N, Isberg R. A Legionella pneumophila-translocated substrate that is required for growth within macrophages and protection from host cell death. Proc Natl Acad Sci U S A. 2006;103:18745-50 pubmed
    ..Defective intracellular growth of the sdhA(-) mutant could be partially suppressed by the action of caspase inhibitors, but caspase-independent cell death pathways eventually aborted replication of the mutant...

More Information


  1. Garcia A, Ihrig M, Fry R, Feng Y, Xu S, Boutin S, et al. Genetic susceptibility to chronic hepatitis is inherited codominantly in Helicobacter hepaticus-infected AB6F1 and B6AF1 hybrid male mice, and progression to hepatocellular carcinoma is linked to hepatic expression of lipogenic genes and immune funct. Infect Immun. 2008;76:1866-76 pubmed publisher
    ..The use of AB6F1 and B6AF1 mice, as well as genetically engineered mice, on a C57BL/6 background will allow studies investigating the role of chronic microbial hepatitis and steatohepatitis in the pathogenesis of liver cancer...
  2. Dalebroux Z, Edwards R, Swanson M. SpoT governs Legionella pneumophila differentiation in host macrophages. Mol Microbiol. 2009;71:640-58 pubmed publisher
    ..Thus, L. pneumophila requires SpoT to monitor FAB and to alternate between replication and transmission in macrophages...
  3. de Wolf H, Luten J, Snel C, Oussoren C, Hennink W, Storm G. In vivo tumor transfection mediated by polyplexes based on biodegradable poly(DMAEA)-phosphazene. J Control Release. 2005;109:275-87 pubmed
    ..The observed preferential tumor gene expression mediated by the p(DMAEA)-ppz polyplexes enables the application of this polymer to deliver therapeutic genes to tumors...
  4. Min Oo G, Fortin A, Tam M, Gros P, Stevenson M. Phenotypic expression of pyruvate kinase deficiency and protection against malaria in a mouse model. Genes Immun. 2004;5:168-75 pubmed
    ..chabaudi infection. The possible molecular basis of the Pklr protective effect is discussed and is under current investigation in these two strains...
  5. Setiady Y, Samy E, Tung K. Maternal autoantibody triggers de novo T cell-mediated neonatal autoimmune disease. J Immunol. 2003;170:4656-64 pubmed
    ..Therefore, a new mechanism of neonatal autoimmunity is presented in which epitope-specific autoantibody stimulates de novo autoimmune pathogenic CD4(+) T cell response...
  6. Sharp C, Thompson C, Samy E, Noelle R, Tung K. CD40 ligand in pathogenesis of autoimmune ovarian disease of day 3-thymectomized mice: implication for CD40 ligand antibody therapy. J Immunol. 2003;170:1667-74 pubmed
  7. Brogdon J, Leitenberg D, Bottomly K. The potency of TCR signaling differentially regulates NFATc/p activity and early IL-4 transcription in naive CD4+ T cells. J Immunol. 2002;168:3825-32 pubmed
    ..These data provide a model for how the strength of TCR signaling can influence the generation of Th1 and Th2 cells...
  8. Nagai H, Kagan J, Zhu X, Kahn R, Roy C. A bacterial guanine nucleotide exchange factor activates ARF on Legionella phagosomes. Science. 2002;295:679-82 pubmed
    ..pneumophila. Translocation of RalF protein through the phagosomal membrane is a dot/icm-dependent process. Thus, RalF is a substrate of the Dot/Icm secretion apparatus...
  9. Fortin A, Cardon L, Tam M, Skamene E, Stevenson M, Gros P. Identification of a new malaria susceptibility locus (Char4) in recombinant congenic strains of mice. Proc Natl Acad Sci U S A. 2001;98:10793-8 pubmed
    ..Our findings provide an entry point for parallel association studies in humans between the syntenic 4q21-4q25 region and susceptibility to disease in endemic areas of malaria...
  10. Su Z, Stevenson M. IL-12 is required for antibody-mediated protective immunity against blood-stage Plasmodium chabaudi AS malaria infection in mice. J Immunol. 2002;168:1348-55 pubmed
  11. Miura M, Morita K, Kobayashi H, Hamilton T, Burdick M, Strieter R, et al. Monokine induced by IFN-gamma is a dominant factor directing T cells into murine cardiac allografts during acute rejection. J Immunol. 2001;167:3494-504 pubmed
    ..Although Mig antagonism delays acute heart allograft rejection, the results also suggest that the alloimmune response circumvents Mig antagonism through alternative mechanisms...
  12. Patel S, Berghout J, Lovegrove F, Ayi K, Conroy A, Serghides L, et al. C5 deficiency and C5a or C5aR blockade protects against cerebral malaria. J Exp Med. 2008;205:1133-43 pubmed publisher
    ..falciparum glycosylphosphatidylinositol and C5aR blockade abrogated these amplified responses. These data provide evidence implicating C5/C5a in the pathogenesis of CM...
  13. Crabbe J, Metten P, Ponomarev I, Prescott C, Wahlsten D. Effects of genetic and procedural variation on measurement of alcohol sensitivity in mouse inbred strains. Behav Genet. 2006;36:536-52 pubmed
    ..In certain instances, substrain seems to matter little, while in others, substrains differed a great deal. These data are generally encouraging about the stability of genetic differences. ..
  14. Udaka N, Miyagi Y, Ito T. Connexin expression in mouse lung tumor. Cancer Lett. 2007;246:224-9 pubmed
    ..Thus, it is likely that alteration of expression of these Cx may be involved in expression of the neoplastic phenotype. ..
  15. Xue C, Wyckoff J, Liang F, Sidani M, Violini S, Tsai K, et al. Epidermal growth factor receptor overexpression results in increased tumor cell motility in vivo coordinately with enhanced intravasation and metastasis. Cancer Res. 2006;66:192-7 pubmed
  16. Lee S, Lim K. Chemopreventive effect of plant originated glycoprotein on colitis-mediated colorectal cancer in A/J mice. J Biomed Sci. 2008;15:111-21 pubmed
    ..Collectively, these results suggest that UDN glycoprotein has chemopreventive activity via modulation of inflammation-related factors responsible for development of colitis-mediated CRC in A/J mice. ..
  17. Chanas S, Collinson J, Ramaesh T, Dorà N, Kleinjan D, Hill R, et al. Effects of elevated Pax6 expression and genetic background on mouse eye development. Invest Ophthalmol Vis Sci. 2009;50:4045-59 pubmed publisher
    ..Some phenotypic differences between PAX77(+/-)<-->wild-type and Pax6(+/-)<-->wild-type chimeras may reflect differences in the levels of PAX77(+/-) and Pax6(+/-) contributions to chimeric lenses. ..
  18. Vassiliou E, Sharma V, Jing H, Sheibanie F, Ganea D. Prostaglandin E2 promotes the survival of bone marrow-derived dendritic cells. J Immunol. 2004;173:6955-64 pubmed
    ..This suggests that PGE(2) acts as an endogenous antiapoptotic factor for DC and raises the possibility of using PGE(2) agonists to increase the survival of Ag-loaded DC following in vivo administration. ..
  19. Moisan J, Camateros P, Thuraisingam T, Marion D, Koohsari H, Martin P, et al. TLR7 ligand prevents allergen-induced airway hyperresponsiveness and eosinophilia in allergic asthma by a MYD88-dependent and MK2-independent pathway. Am J Physiol Lung Cell Mol Physiol. 2006;290:L987-95 pubmed
    ..These results clearly demonstrate the anti-inflammatory effect of imidazoquinolines in an allergic asthma model as well as the clinical potential of TLR7 ligands in the treatment of allergic diseases. ..
  20. Shibamori M, Ogino K, Kambayashi Y, Ishiyama H. Intranasal mite allergen induces allergic asthma-like responses in NC/Nga mice. Life Sci. 2006;78:987-94 pubmed
    ..None of the study parameters were increased in response to intranasal exposure to ovalbumin. These data demonstrated that NC/Nga mice developed allergic asthma-like responses after intranasal exposure to mite allergens. ..
  21. Kulikov A, Tikhonova M, Kulikov V. Automated measurement of spatial preference in the open field test with transmitted lighting. J Neurosci Methods. 2008;170:345-51 pubmed publisher
    ..The effects of arena shape (circle or square) and a novel object presence in the center of arena on the open field behavior in mice were studied. ..
  22. Funeshima N, Fujino M, Kitazawa Y, Hara Y, Hara Y, Hayakawa K, et al. Inhibition of allogeneic T-cell responses by dendritic cells expressing transduced indoleamine 2,3-dioxygenase. J Gene Med. 2005;7:565-75 pubmed
    ..These results suggest that overexpression of IDO in the DCs effectively inhibited T-cell proliferation, and may expand a new immunomodulatory strategy for the prevention of allo-rejection of organ transplantation. ..
  23. Dong M, Guda K, Nambiar P, Nakanishi M, Lichtler A, Nishikawa M, et al. Azoxymethane-induced pre-adipocyte factor 1 (Pref-1) functions as a differentiation inhibitor in colonic epithelial cells. Carcinogenesis. 2004;25:2239-46 pubmed
    ..In addition, detection of Pref-1 in a human colon tumor cell line suggests that it may also participate in human colon tumorigenesis. ..
  24. Fung M, Lu M, Fure H, Sun W, Sun C, Shi N, et al. Pre-neutralization of C5a-mediated effects by the monoclonal antibody 137-26 reacting with the C5a moiety of native C5 without preventing C5 cleavage. Clin Exp Immunol. 2003;133:160-9 pubmed
    ..The antibody may have therapeutic potential in inflammatory diseases where C5a inhibition combined with an operative lytic pathway of C5b-9 is particularly desired. ..
  25. Sugihara I, Yoshida M, Shigenobu T, Takagi H, Maruyama K, Takeuchi N, et al. Different progression of tumor xenografts between mucin-producing and mucin-non-producing mammary adenocarcinoma-bearing mice. Cancer Res. 2006;66:6175-82 pubmed
    ..These results suggest that mucins play an important role in tumor progression through overproduction of PGE2. ..
  26. Shimizu T, Kozono Y, Kozono H, Oda M, Azuma T. Affinity maturation of secreted IgM pentamers on B cells. Int Immunol. 2004;16:675-84 pubmed
    ..Comparison of the binding ratio of NP(0.9)-BSA:NP(5)-BSA between B cells of primary and secondary immunization suggested that the affinity of IgM matured during immunization. ..
  27. Cemazar M, Golzio M, Sersa G, Hojman P, Kranjc S, Mesojednik S, et al. Control by pulse parameters of DNA electrotransfer into solid tumors in mice. Gene Ther. 2009;16:635-44 pubmed publisher
  28. Wang Y, Zhang Z, Kastens E, Lubet R, You M. Mice with alterations in both p53 and Ink4a/Arf display a striking increase in lung tumor multiplicity and progression: differential chemopreventive effect of budesonide in wild-type and mutant A/J mice. Cancer Res. 2003;63:4389-95 pubmed
    ..Thus, the mutant A/J mouse model should prove useful for chemoprevention studies. ..
  29. Baig E, Fish E. Distinct signature type I interferon responses are determined by the infecting virus and the target cell. Antivir Ther. 2008;13:409-22 pubmed
    ..The extent of IFN response to viral infection influences the subsequent biological outcome: a robust IFN response prescribes a level of resistance, whereas a poor IFN response contributes towards a permissive phenotype for infection. ..
  30. Croce M, Corrias M, Orengo A, Brizzolara A, Carlini B, Borghi M, et al. Transient depletion of CD4(+) T cells augments IL-21-based immunotherapy of disseminated neuroblastoma in syngeneic mice. Int J Cancer. 2010;127:1141-50 pubmed publisher
  31. Mernitz H, Lian F, Smith D, Meydani S, Wang X. Fish oil supplementation inhibits NNK-induced lung carcinogenesis in the A/J mouse. Nutr Cancer. 2009;61:663-9 pubmed publisher
    ..These data suggest that fish oil with a low ratio of n-6/n-3 PUFA could be beneficial in the prevention of lung carcinogenesis. ..
  32. Rivera J, Casadevall A. Mouse genetic background is a major determinant of isotype-related differences for antibody-mediated protective efficacy against Cryptococcus neoformans. J Immunol. 2005;174:8017-26 pubmed
    ..The dependence of isotype efficacy on host genetics underscores a previously unsuspected complex relationship between the cellular and humoral arms of the adaptive immune response. ..
  33. Yang L, Boyd K, Kaste S, Kamdem Kamdem L, RAHIJA R, Relling M. A mouse model for glucocorticoid-induced osteonecrosis: effect of a steroid holiday. J Orthop Res. 2009;27:169-75 pubmed publisher
    ..Moreover, asparaginase hastened osteonecrosis, indicating that drugs may interact with glucocorticoids to affect osteonecrosis risk. ..
  34. Meza N, Alonso Ferrero M, Navarro S, Quintana Bustamante O, Valeri A, Garcia Gomez M, et al. Rescue of pyruvate kinase deficiency in mice by gene therapy using the human isoenzyme. Mol Ther. 2009;17:2000-9 pubmed publisher
    ..Our data suggest that transduction of human RPK cDNA in PKLR mutated HSCs could be an effective strategy in severe cases of PKD. ..
  35. Guler M, Ligons D, Wang Y, Bianco M, Broman K, Rose N. Two autoimmune diabetes loci influencing T cell apoptosis control susceptibility to experimental autoimmune myocarditis. J Immunol. 2005;174:2167-73 pubmed
    ..SW mice demonstrate the same characteristics in apoptosis. These results suggest that common pathogenetic mechanisms involving apoptosis of both thymic and peripheral T cells are shared by multiple autoimmune diseases. ..
  36. D Orazio S, Troese M, Starnbach M. Cytosolic localization of Listeria monocytogenes triggers an early IFN-gamma response by CD8+ T cells that correlates with innate resistance to infection. J Immunol. 2006;177:7146-54 pubmed
    ..These data suggest that participation of memory CD8+ T cells in the early immune response against L. monocytogenes correlates with innate host resistance to infection. ..
  37. Bullen J, Ziotopoulou M, Ungsunan L, Misra J, Alevizos I, Kokkotou E, et al. Short-term resistance to diet-induced obesity in A/J mice is not associated with regulation of hypothalamic neuropeptides. Am J Physiol Endocrinol Metab. 2004;287:E662-70 pubmed
    ..The role of additional molecules discovered by microarray analysis needs to be further explored in the future. ..
  38. Adams B, Nagy N, Paulart F, Vanderhaeghen M, Goldman M, Flamand V. CD8+ T lymphocytes regulating Th2 pathology escape neonatal tolerization. J Immunol. 2003;171:5071-6 pubmed
    ..We conclude that regulatory CD8(+) T cells controlling Th2 responses are functional in early life and escape neonatal tolerization. ..
  39. Carvalho J, Leite A, Yan D, Everett E, Whitford G, Buzalaf M. Influence of genetic background on fluoride metabolism in mice. J Dent Res. 2009;88:1054-8 pubmed publisher
    ..In conclusion, these strains differ with respect to several features of F metabolism, and amelogenesis in the 129P3/J strain seems to be unaffected by high F exposure. ..
  40. Gonsenhauser I, Wilson C, Han F, Strohl K, Dick T. Strain differences in murine ventilatory behavior persist after urethane anesthesia. J Appl Physiol (1985). 2004;97:888-94 pubmed
    ..The neural substrate for these differences, at least partially, exists within subcortical structures generating the breathing pattern. ..
  41. Yuan H, Li M, Ma L, Hsin M, Mok T, Underwood M, et al. 15-Lipoxygenases and its metabolites 15(S)-HETE and 13(S)-HODE in the development of non-small cell lung cancer. Thorax. 2010;65:321-6 pubmed publisher
    ..The activation of PPARgamma inhibits cell growth and induces apoptosis in some cancers. The role of 15(S)-HETE) and 13(S)-HODE in the development of lung cancer is not clear...
  42. Araújo A, de Alencar B, Vasconcelos J, Hiyane M, Marinho C, Penido M, et al. CD8+-T-cell-dependent control of Trypanosoma cruzi infection in a highly susceptible mouse strain after immunization with recombinant proteins based on amastigote surface protein 2. Infect Immun. 2005;73:6017-25 pubmed
    ..cruzi infection. ..
  43. Hessel E, van Gassen K, Wolterink Donselaar I, Stienen P, Fernandes C, Brakkee J, et al. Phenotyping mouse chromosome substitution strains reveal multiple QTLs for febrile seizure susceptibility. Genes Brain Behav. 2009;8:248-55 pubmed publisher
    ..This will increase our understanding of human FS, working toward the identification of new therapeutic targets. ..
  44. Walker S, Aboka A, Ogagan P, Barksdale E. Murine neuroblastoma attenuates dendritic cell cysteine cysteine receptor 7 (CCR7) expression. J Pediatr Surg. 2005;40:983-7 pubmed
    ..Immunotherapeutic strategies to bypass or augment CCR7-dependent DC trafficking may improve survival for patients with aggressive disease. ..
  45. Paulsen J, Knutsen H, Ølstørn H, Løberg E, Alexander J. Identification of flat dysplastic aberrant crypt foci in the colon of azoxymethane-treated A/J mice. Int J Cancer. 2006;118:540-6 pubmed
    ..Classical elevated ACF do not seem to be as closely related to tumorigenesis. ..
  46. Estensen R, Jordan M, Wiedmann T, Galbraith A, Steele V, Wattenberg L. Effect of chemopreventive agents on separate stages of progression of benzo[alpha]pyrene induced lung tumors in A/J mice. Carcinogenesis. 2004;25:197-201 pubmed
    ..In summary, budesonide is a chemopreventive agent that has inhibitory effects on B[alpha]P induced carcinogenesis of the lung in A/J mice at all stages of progression from hyperplasia formation to cancer. ..
  47. Friedman L, Haines A, Klann K, Gallaugher L, Salibra L, Han F, et al. Ventilatory behavior during sleep among A/J and C57BL/6J mouse strains. J Appl Physiol (1985). 2004;97:1787-95 pubmed
    ..035) and B6 (P < 0.0001). We conclude that genetic background affects features of breathing during NREM and REM sleep, despite broad changes in state, metabolism, and heart rate. ..
  48. Sharma R, Alegria J, Talor M, Rose N, Caturegli P, Burek C. Iodine and IFN-gamma synergistically enhance intercellular adhesion molecule 1 expression on NOD.H2h4 mouse thyrocytes. J Immunol. 2005;174:7740-5 pubmed
    ..These findings suggest that iodine and IFN-gamma cooperate to promote thyroidal expression of ICAM-1 in this mouse model of thyroiditis, highlighting the complex interplay present in the pathogenesis of Hashimoto's thyroiditis. ..
  49. Balbir A, Lee H, Okumura M, Biswal S, Fitzgerald R, Shirahata M. A search for genes that may confer divergent morphology and function in the carotid body between two strains of mice. Am J Physiol Lung Cell Mol Physiol. 2007;292:L704-15 pubmed
    ..Particularly, Gdnf, Bmp2, Kcnmb2, Tph1, Hif1a, and Arnt2 may contribute to the functional differences in the CB between the two strains. Bmp2, Phox2b, Dlx2, and Msx2 may be important for the morphological differences. ..
  50. Komaru A, Ueda Y, Furuya A, Tanaka S, Yoshida K, Kato T, et al. Sustained and NK/CD4+ T cell-dependent efficient prevention of lung metastasis induced by dendritic cells harboring recombinant Sendai virus. J Immunol. 2009;183:4211-9 pubmed publisher
  51. Li L, Yang Y, Wong G, Stevens R. Mast cells in airway hyporesponsive C3H/HeJ mice express a unique isoform of the signaling protein Ras guanine nucleotide releasing protein 4 that is unresponsive to diacylglycerol and phorbol esters. J Immunol. 2003;171:390-7 pubmed
    ..MCs play a central role in allergic inflammation. The discovery of a novel isoform of mRasGRP4 in hyporesponsive mice suggests that airway reactivity is influenced by RasGRP4-dependent signaling events in pulmonary MCs...
  52. Okuyama S, Okuyama J, Okuyama J, Tamatsu Y, Shimada K, Hoshi H, et al. The arterial circle of Willis of the mouse helps to decipher secrets of cerebral vascular accidents in the human. Med Hypotheses. 2004;63:997-1009 pubmed
    ..Thus, anatomical findings and possibly functions of the arterial circle of Willi may vary from one species to another, depending on one's specific cerebral evolution...
  53. Garbow J, Wang M, Wang Y, Lubet R, You M. Quantitative monitoring of adenocarcinoma development in rodents by magnetic resonance imaging. Clin Cancer Res. 2008;14:1363-7 pubmed publisher
    ..The goal of this work was to monitor quantitatively the development and progression of adenocarcinoma in a time course study of mice treated with the carcinogen urethane using in vivo small-animal magnetic resonance imaging (MRI)...
  54. Yuan J, Cheung P, Zhang H, Chau D, Yanagawa B, Cheung C, et al. A phosphorothioate antisense oligodeoxynucleotide specifically inhibits coxsackievirus B3 replication in cardiomyocytes and mouse hearts. Lab Invest. 2004;84:703-14 pubmed
    ..Taken together, our results demonstrated a great potential for AS-7 to be further developed into an effective treatment towards viral myocarditis as well as other diseases caused by CVB3 infection...
  55. Clark D, Blois S, Kandil J, Handjiski B, Manuel J, Arck P. Reduced uterine indoleamine 2,3-dioxygenase versus increased Th1/Th2 cytokine ratios as a basis for occult and clinical pregnancy failure in mice and humans. Am J Reprod Immunol. 2005;54:203-16 pubmed
    ..Could stress act by reducing IDO expression?..
  56. Amano H, Bickerstaff A, Orosz C, Novick A, Toma H, Fairchild R. Absence of recipient CCR5 promotes early and increased allospecific antibody responses to cardiac allografts. J Immunol. 2005;174:6499-508 pubmed
    ..These results suggest dysregulation of alloreactive Ab responses and Ab-mediated cardiac allograft rejection in the absence of recipient CCR5...
  57. Scorza T, Grubb K, Cambos M, Santamaria C, Tshikudi Malu D, Spithill T. Vaccination with a Plasmodium chabaudi adami multivalent DNA vaccine cross-protects A/J mice against challenge with P. c. adami DK and virulent Plasmodium chabaudi chabaudi AS parasites. Int J Parasitol. 2008;38:819-27 pubmed
  58. Liu B, Zhang X, Zhang W, Zhen H. New enlightenment of French Paradox: resveratrol's potential for cancer chemoprevention and anti-cancer therapy. Cancer Biol Ther. 2007;6:1833-6 pubmed
    ..Anti-carcinogenic potential for cancer chemoprevention and anticancer therapy, which is one of the pleiotropic effects of resveratrol, is so called a new enlightenment of French Paradox...
  59. Xu L, Shen X, Bryan A, Banga S, Swanson M, Luo Z. Inhibition of host vacuolar H+-ATPase activity by a Legionella pneumophila effector. PLoS Pathog. 2010;6:e1000822 pubmed publisher
    ..Our results indicate that direct targeting of v-ATPase by secreted proteins constitutes a virulence strategy for L. pneumophila, a vacuolar pathogen of macrophages and amoebae...
  60. Higuchi T, Maruyama T, Jaramillo A, Mohanakumar T. Induction of obliterative airway disease in murine tracheal allografts by CD8+ CTLs recognizing a single minor histocompatibility antigen. J Immunol. 2005;174:1871-8 pubmed
    ..In conclusion, a single mHAg mismatch can induce the development of OAD. These data also suggest that mHAg-reactive CD8+ CTLs may play an important role in the pathogenesis of chronic lung allograft rejection in humans...
  61. Young N, Wat S, Diewert V, Browder L, Hallgrimsson B. Comparative morphometrics of embryonic facial morphogenesis: implications for cleft-lip etiology. Anat Rec (Hoboken). 2007;290:123-39 pubmed
    ..A combination of molecular experimentation and phenotypic analysis of shape is required to test these hypotheses further...
  62. Liu P, Vikis H, James M, Lu Y, Wang D, Liu H, et al. Identification of Las2, a major modifier gene affecting the Pas1 mouse lung tumor susceptibility locus. Cancer Res. 2009;69:6290-8 pubmed publisher
    ..Deletion of LAS2 was observed in approximately 40% of human lung adenocarcinomas, implying that loss of function of LAS2 may be a key step for lung tumorigenesis...
  63. Mehta N, Benoit S, Mysore J, Sousa R, Maier R. Helicobacter hepaticus hydrogenase mutants are deficient in hydrogen-supported amino acid uptake and in causing liver lesions in A/J mice. Infect Immun. 2005;73:5311-8 pubmed
  64. Chen H, Hofman F, Kung J, Lin Y, Wu Hsieh B. Both virus and tumor necrosis factor alpha are critical for endothelium damage in a mouse model of dengue virus-induced hemorrhage. J Virol. 2007;81:5518-26 pubmed
    ..This finding highlights the contribution of the innate immune response to dengue hemorrhage...
  65. Joller N, Spörri R, Hilbi H, Oxenius A. Induction and protective role of antibodies in Legionella pneumophila infection. Eur J Immunol. 2007;37:3414-23 pubmed
    ..Actively or passively immunized mice or mice that were infected with opsonized Lpn had 50-100-fold reduced bacterial titers compared to naive animals, clearly demonstrating the capacity of Ab to protect against infection with Lpn...
  66. Winders B, Schwartz R, Bruniquel D. A distinct region of the murine IFN-gamma promoter is hypomethylated from early T cell development through mature naive and Th1 cell differentiation, but is hypermethylated in Th2 cells. J Immunol. 2004;173:7377-84 pubmed
    ..Our experiments support a new model of IFN-gamma chromatin structural changes in murine T cell development that differs from what has been previously published for human T cells...
  67. Oumouna Benachour K, Oumouna M, Zerfaoui M, Hans C, Fallon K, Boulares A. Intrinsic resistance to apoptosis of colon epithelial cells is a potential determining factor in the susceptibility of the A/J mouse strain to dimethylhydrazine-induced colon tumorigenesis. Mol Carcinog. 2007;46:993-1002 pubmed
    ..These results strongly suggest that a higher intrinsic resistance to apoptosis of colon epithelial cells may be an important determinant of predisposition to colon tumorigenesis in the A/J mouse strain...
  68. Pereira C, Modolell M, Frey J, Lefkovits I. Gene expression in IFN-gamma-activated murine macrophages. Braz J Med Biol Res. 2004;37:1795-809 pubmed
    ..In this respect, a down-regulation of the main murine hepatitis virus 3 receptor gene was detected only in IFN-gamma-activated macrophages of resistant mice...
  69. Tanaka S, Mizorogi T, Nishijima K, Kuwahara S, Tsujio M, Aoyama H, et al. Body and major organ weights of A/J-Chr 11(SM) consomic mice. Exp Anim. 2009;58:357-61 pubmed
  70. Losick V, Haenssler E, Moy M, Isberg R. LnaB: a Legionella pneumophila activator of NF-kappaB. Cell Microbiol. 2010;12:1083-97 pubmed publisher
    ..These data indicate that LnaB is an Icm/Dot substrate that contributes to NF-kappaB activation during L. pneumophila infection in host cells...
  71. Brando C, Ware L, Freyberger H, Kathcart A, Barbosa A, Cayphas S, et al. Murine immune responses to liver-stage antigen 1 protein FMP011, a malaria vaccine candidate, delivered with adjuvant AS01B or AS02A. Infect Immun. 2007;75:838-45 pubmed
  72. Molofsky A, Byrne B, Whitfield N, Madigan C, Fuse E, Tateda K, et al. Cytosolic recognition of flagellin by mouse macrophages restricts Legionella pneumophila infection. J Exp Med. 2006;203:1093-104 pubmed
    ..Accordingly, macrophages respond to cytosolic flagellin by a mechanism that requires Naip5 and caspase 1 to restrict bacterial replication and release proinflammatory cytokines that control L. pneumophila infection...
  73. Mayne C, Amanna I, Nashold F, Hayes C. Systemic autoimmunity in BAFF-R-mutant A/WySnJ strain mice. Eur J Immunol. 2008;38:587-98 pubmed publisher
    ..Baffr(+/+) mice carrying a wild-type allele developed none of these phenotypes. Our data provide the first evidence linking altered BAFF-R signaling to the development of B cell-mediated autoimmunity...
  74. Fichera A, Little N, Dougherty U, Mustafi R, Cerda S, Li Y, et al. A vitamin D analogue inhibits colonic carcinogenesis in the AOM/DSS model. J Surg Res. 2007;142:239-45 pubmed
    ..Our aim was to evaluate the anti-inflammatory and chemopreventive efficacy of the vitamin D analogue Ro26-2198 in the AOM/DSS model and in vitro in HCA-7 colon cancer cells...
  75. Sera T, Uesugi K, Himeno R, Yagi N. Small airway changes in healthy and ovalbumin-treated mice during quasi-static lung inflation. Respir Physiol Neurobiol. 2007;156:304-11 pubmed
    ..70 for larger airways. The morphometric changes and sC(aw) in asthma model mice were significantly lower than those of healthy mice. The differences in sC(aw) between healthy and asthma model mice were greater for smaller airways...
  76. Couppis M, Kennedy C, Stanwood G. Differences in aggressive behavior and in the mesocorticolimbic DA system between A/J and BALB/cJ mice. Synapse. 2008;62:715-24 pubmed publisher
    ..Although correlative in nature, these data suggest that differences in mesocorticolimbic DA and serotonin systems may contribute to endogenous differences in aggression...
  77. Wang M, Lemon W, Liu G, Wang Y, Iraqi F, Malkinson A, et al. Fine mapping and identification of candidate pulmonary adenoma susceptibility 1 genes using advanced intercross lines. Cancer Res. 2003;63:3317-24 pubmed
    ..The Ak015530 carries an amino acid polymorphism, but this polymorphism does not cosegregate with mouse lung tumor susceptibility. Thus, these 4 genes are less likely candidates for the Pas1 locus...
  78. Ng L, Ng C, Woehl B, Sutherland A, Huo J, Xu S, et al. BAFF costimulation of Toll-like receptor-activated B-1 cells. Eur J Immunol. 2006;36:1837-46 pubmed
    ..Thus, as TLR are innate immune receptors and B-1 cells are "innate-like" lymphocytes, our data provide evidence that BAFF plays a role in innate immunity...
  79. Lopez E, del Pozo V, Miguel T, Sastre B, Seoane C, Civantos E, et al. Inhibition of chronic airway inflammation and remodeling by galectin-3 gene therapy in a murine model. J Immunol. 2006;176:1943-50 pubmed
    ..Plasmid-encoding Gal-3 acts as a novel treatment for chronic asthma in mice producing nearly complete blockade of Ag responses with respect to eosinophil airway accumulation, airway hyperresponsiveness, and remodeling...
  80. Akagi K, Li J, Stephens R, Volfovsky N, Symer D. Extensive variation between inbred mouse strains due to endogenous L1 retrotransposition. Genome Res. 2008;18:869-80 pubmed publisher
    ..Thus, recent endogenous L1 retrotransposition has diversified genomic structures and transcripts extensively, distinguishing mouse lineages and driving a major portion of natural genetic variation...
  81. West K, Linnoila I, Brognard J, Belinsky S, Harris C, Dennis P. Tobacco carcinogen-induced cellular transformation increases Akt activation in vitro and in vivo. Chest. 2004;125:101S-2S pubmed
  82. Alyaqoub F, Liu Y, Tao L, Steele V, Lubet R, Pereira M. Modulation by bexarotene of mRNA expression of genes in mouse lung tumors. Mol Carcinog. 2008;47:165-71 pubmed
  83. Rahman Z, Manser T. B cells expressing Bcl-2 and a signaling-impaired BAFF-specific receptor fail to mature and are deficient in the formation of lymphoid follicles and germinal centers. J Immunol. 2004;173:6179-88 pubmed
    ..These results suggest that the BAFF-R and Bcl-2 regulate key and nonoverlapping aspects of peripheral B cell survival and development...
  84. Yan X, Johnson B, Orentas R. Murine CD8 lymphocyte expansion in vitro by artificial antigen-presenting cells expressing CD137L (4-1BBL) is superior to CD28, and CD137L expressed on neuroblastoma expands CD8 tumour-reactive effector cells in vivo. Immunology. 2004;112:105-16 pubmed
  85. Bortner J, Das A, Umstead T, Freeman W, Somiari R, Aliaga C, et al. Down-regulation of 14-3-3 isoforms and annexin A5 proteins in lung adenocarcinoma induced by the tobacco-specific nitrosamine NNK in the A/J mouse revealed by proteomic analysis. J Proteome Res. 2009;8:4050-61 pubmed publisher
    ..Identification of these proteins in surrogate tissue in future studies would be highly useful in early detection of lung adenocarcinoma and clinical chemoprevention trials...
  86. Wang C, Gao D, Kaltenboeck B. Acute Chlamydia pneumoniae reinfection accelerates the development of insulin resistance and diabetes in obese C57BL/6 mice. J Infect Dis. 2009;200:279-87 pubmed publisher
    ..Animal models contribute critically to the mechanistic understanding of infectious enhancement of inflammatory diseases, which share insulin resistance as the central pathophysiological defect...
  87. Fu H, He J, Mei F, Zhang Q, Hara Y, Ryota S, et al. Lung cancer inhibitory effect of epigallocatechin-3-gallate is dependent on its presence in a complex mixture (polyphenon E). Cancer Prev Res (Phila). 2009;2:531-7 pubmed publisher
    ..Furthermore, in aerosolized form, EGCG, which is thought to be the most active component of Polyphenon E, has to be present with other tea catechins to show chemopreventive activity on lung tumorigenesis...
  88. Whitney I, Raven M, Ciobanu D, Williams R, Reese B. Multiple genes on chromosome 7 regulate dopaminergic amacrine cell number in the mouse retina. Invest Ophthalmol Vis Sci. 2009;50:1996-2003 pubmed publisher
    ..The size of the dopaminergic amacrine (DA) cell population is a highly heritable trait exhibiting sixfold variation among inbred strains of mice and is used here to identify genes that modulate the number of DA cells...
  89. Popov S, Günter E, Markov P, Smirnov V, Khramova D, Ovodov Y. Adjuvant effect of lemnan, pectic polysaccharide of callus culture of Lemna minor L. at oral administration. Immunopharmacol Immunotoxicol. 2006;28:141-52 pubmed
    ..Thus, lemnan appeared to be useful as the adjuvant for oral immunization...
  90. Rogers A, Theve E, Feng Y, Fry R, Taghizadeh K, Clapp K, et al. Hepatocellular carcinoma associated with liver-gender disruption in male mice. Cancer Res. 2007;67:11536-46 pubmed
    ..This model introduces a novel mechanism of inflammation-associated carcinogenesis consistent with male-predominant HCC risk...
  91. Wang M, Devereux T, Vikis H, McCulloch S, Holliday W, Anna C, et al. Pol iota is a candidate for the mouse pulmonary adenoma resistance 2 locus, a major modifier of chemically induced lung neoplasia. Cancer Res. 2004;64:1924-31 pubmed
    ..Thus, our data support the Pol iota gene as a modifier of lung tumorigenesis by altering DNA polymerase activity...