congenic mice

Summary

Summary: Mouse strains constructed to possess identical genotypes except for a difference at a single gene locus.

Top Publications

  1. Shao H, Burrage L, Sinasac D, Hill A, Ernest S, O BRIEN W, et al. Genetic architecture of complex traits: large phenotypic effects and pervasive epistasis. Proc Natl Acad Sci U S A. 2008;105:19910-4 pubmed publisher
    ..These results have implications for identification of complex trait genes, developmental and physiological studies of phenotypic variation, and opportunities to engineer phenotypic outcomes in complex biological systems...
  2. Gale G, Yazdi R, Khan A, Lusis A, Davis R, Smith D. A genome-wide panel of congenic mice reveals widespread epistasis of behavior quantitative trait loci. Mol Psychiatry. 2009;14:631-45 pubmed publisher
    ..These data suggest that epistasis decreases sensitivity of locus detection in traditional crosses and demonstrate the utility of the GTM for mapping complex behavioral traits with high sensitivity and precision...
  3. Lemay A, Haston C. Bleomycin-induced pulmonary fibrosis susceptibility genes in AcB/BcA recombinant congenic mice. Physiol Genomics. 2005;23:54-61 pubmed
    ..The putative loci included alleles from both the B6 and A/J strains as increasing the fibrosis response of congenic mice. Gene expression analysis with microarrays revealed 3,304 genes or expressed sequence tags to be ..
  4. Irie J, Reck B, Wu Y, Wicker L, Howlett S, Rainbow D, et al. Genome-wide microarray expression analysis of CD4+ T Cells from nonobese diabetic congenic mice identifies Cd55 (Daf1) and Acadl as candidate genes for type 1 diabetes. J Immunol. 2008;180:1071-9 pubmed
    NOD.Idd3/5 congenic mice have insulin-dependent diabetes (Idd) regions on chromosomes 1 (Idd5) and 3 (Idd3) derived from the nondiabetic strains B10 and B6, respectively. NOD...
  5. Tirkos S, Newbigging S, Nguyen V, Keet M, Ackerley C, Kent G, et al. Expression of S100A8 correlates with inflammatory lung disease in congenic mice deficient of the cystic fibrosis transmembrane conductance regulator. Respir Res. 2006;7:51 pubmed
    ..In contrast, lungs of congenic BALB/c CF mice remain unaffected. The basis of the neutrophil influx to the airways of CF patients and C57BL/6 mice, and its precipitating factor(s) (spontaneous or infection induced) remains unclear...
  6. Thifault S, Ondrej S, Sun Y, Fortin A, Skamene E, Lalonde R, et al. Genetic determinants of emotionality and stress response in AcB/BcA recombinant congenic mice and in silico evidence of convergence with cardiovascular candidate genes. Hum Mol Genet. 2008;17:331-44 pubmed
    ..Functional polymorphisms in regulatory elements of candidate genes of the CV/inflammatory/immune systems support the hypothesis of genetically-altered environmental susceptibility in CV disease development...
  7. Farber C, Corva P, Medrano J. Genome-wide isolation of growth and obesity QTL using mouse speed congenic strains. BMC Genomics. 2006;7:102 pubmed
    ..To confirm and further characterize each QTL, two panels of speed congenic strains were developed by introgressing CAST/EiJ (CAST) QTL alleles onto either mutant C57Bl/6J-hg/hg (HG) or wild type C57Bl/6J (B6) genetic backgrounds...
  8. Costford S, Chaudhry S, Salkhordeh M, Harper M. Effects of the presence, absence, and overexpression of uncoupling protein-3 on adiposity and fuel metabolism in congenic mice. Am J Physiol Endocrinol Metab. 2006;290:E1304-12 pubmed
    ..Results are consistent with a role for UCP3 in preventing accumulation of triglyceride in both adipose tissue and muscle...
  9. Siesser W, Zhang X, Jacobsen J, Sotnikova T, Gainetdinov R, Caron M. Tryptophan hydroxylase 2 genotype determines brain serotonin synthesis but not tissue content in C57Bl/6 and BALB/c congenic mice. Neurosci Lett. 2010;481:6-11 pubmed publisher
    ..At the same time, 5-hydroxyindoleacetic acid (5-HIAA) was significantly elevated in BALB/c congenic mice. In C57Bl/6 mice, there was no effect of genotype on 5-HIAA levels...

More Information

Publications70

  1. Bleich E, Leonhard Marek S, Beyerbach M, Breves G. Characterisation of chloride currents across the proximal colon in CftrTgH(neoim)1Hgu congenic mice. J Comp Physiol B. 2007;177:61-73 pubmed
    ..aim of the present study to investigate chloride secretion across the proximal colon of Cftr (TgH(neoim)1Hgu) congenic mice. Stripped epithelia were incubated in Ussing chambers and the electrophysiological data were compared between ..
  2. Ridgway W. Dissecting genetic control of autoimmunity in NOD congenic mice. Immunol Res. 2006;36:189-95 pubmed
    ..genetic control of autoimmune disease and autoimmune phenotypes using a series of nonobese diabetic (NOD) congenic mice. NOD congenic mice have regions from B6/B10 introgressed onto the NOD genetic background, which reduces the ..
  3. Suemizu H, Yagihashi C, Mizushima T, Ogura T, Etoh T, Kawai K, et al. Establishing EGFP congenic mice in a NOD/Shi-scid IL2Rg(null) (NOG) genetic background using a marker-assisted selection protocol (MASP). Exp Anim. 2008;57:471-7 pubmed
    ..These results suggest that the NOG-EGFP mice, which were generated using the congenic method with MASP, acquired the immunological properties of the NOG mice...
  4. Yamanouchi J, Rainbow D, Serra P, Howlett S, Hunter K, Garner V, et al. Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity. Nat Genet. 2007;39:329-37 pubmed
    ..Reduced IL-2 production achieved by either genetic mechanism correlates with reduced function of CD4(+) CD25(+) regulatory T cells, which are critical for maintaining immune homeostasis. ..
  5. Robling A, Warden S, Shultz K, Beamer W, Turner C. Genetic effects on bone mechanotransduction in congenic mice harboring bone size and strength quantitative trait loci. J Bone Miner Res. 2007;22:984-91 pubmed
    ..Bone size was not consistently associated with mechano-responsiveness, indicating that the genetic regulation of mechanotransduction is a complex process that involves a number of genes and is sex-specific...
  6. Hunter K, Rainbow D, Plagnol V, Todd J, Peterson L, Wicker L. Interactions between Idd5.1/Ctla4 and other type 1 diabetes genes. J Immunol. 2007;179:8341-9 pubmed
    ..This masking of CTLA-4 alleles by different genetic backgrounds provides an explanation for our observation that the human CTLA-4 gene is only associated with T1D in the subgroup of human T1D patients with anti-thyroid autoimmunity...
  7. Johannesson M, Olsson L, Lindqvist A, Moller S, Koczan D, Wester Rosenlöf L, et al. Gene expression profiling of arthritis using a QTL chip reveals a complex gene regulation of the Cia5 region in mice. Genes Immun. 2005;6:575-83 pubmed
    ..The expression of QTL genes was compared between parental and congenic mice in lymph node, spleen and paw samples in five biological replicates and in dye-swapped experiments at three ..
  8. Lemay A, Haston C. Radiation-induced lung response of AcB/BcA recombinant congenic mice. Radiat Res. 2008;170:299-306 pubmed publisher
    ..The data for RC mice support the association of specific inflammatory cells with the development of radiation-induced lung disease and provide informative strains with which to dissect the genetic basis of these complex traits...
  9. de Ledesma A, Desai A, Bolivar V, Symula D, Flaherty L. Two new behavioral QTLs, Emo4 and Reb1, map to mouse Chromosome 1: Congenic strains and candidate gene identification studies. Mamm Genome. 2006;17:111-8 pubmed
  10. Lee P, Ge B, Greenwood C, Sinnett D, Fortin Y, Brunet S, et al. Mapping cis-acting regulatory variation in recombinant congenic strains. Physiol Genomics. 2006;25:294-302 pubmed
    ..We propose the use of this integrated experimental approach in multiple tissues from this and other RCS panels as a means for genome-wide cataloging of genetic regulatory mechanisms in laboratory strains of mice...
  11. Rathkolb B, Noyes H, Brass A, Dark P, Fuchs H, Gailus Durner V, et al. Clinical chemistry of congenic mice with quantitative trait loci for predicted responses to Trypanosoma congolense infection. Infect Immun. 2009;77:3948-57 pubmed publisher
    ..congolense. Congenic mice carrying the C57BL/6 resistance alleles on the A/J background were developed for each of these loci...
  12. Hamilton Williams E, Martinez X, Lyman M, Hunter K, Wicker L, Sherman L. The use of idd congenic mice to identify checkpoints of peripheral tolerance to islet antigen. Ann N Y Acad Sci. 2007;1103:118-27 pubmed
    ..We are currently identifying the cell types and mechanisms that are critical for tolerance induction at each checkpoint...
  13. Irie J, Wu Y, Wicker L, Rainbow D, Nalesnik M, Hirsch R, et al. NOD.c3c4 congenic mice develop autoimmune biliary disease that serologically and pathogenetically models human primary biliary cirrhosis. J Exp Med. 2006;203:1209-19 pubmed
    ..Using a congenic mapping approach, we define the first ABD (Abd) locus, Abd1. These results identify the NOD.c3c4 mouse as the first spontaneous mouse model of PBC. ..
  14. Liljander M, Sällström M, Andersson S, Wernhoff P, Andersson A, Holmdahl R, et al. Identification of genetic regions of importance for reproductive performance in female mice. Genetics. 2006;173:901-9 pubmed
    ..It is well known that reproductive performance is polygenically controlled, and the identification of the major loci in this complex process opens the possibility of investigating the natural genetic control of reproduction...
  15. Gill K, Boyle A. Genetic basis for the psychostimulant effects of nicotine: a quantitative trait locus analysis in AcB/BcA recombinant congenic mice. Genes Brain Behav. 2005;4:401-11 pubmed
    ..A number of putative candidate genes were in proximity to regions identified with nicotine sensitivity, including the alpha2 subunit of the nicotinic acetylcholine receptor and the dopamine D3 receptor...
  16. Martomo S, Yang W, Vaisman A, Maas A, Yokoi M, Hoeijmakers J, et al. Normal hypermutation in antibody genes from congenic mice defective for DNA polymerase iota. DNA Repair (Amst). 2006;5:392-8 pubmed
    ..Class switch recombination and hypermutation were studied in these mice and in congenic mice doubly deficient for both polymerases iota and eta...
  17. Irie J, Wu Y, Sass D, Ridgway W. Genetic control of anti-Sm autoantibody production in NOD congenic mice narrowed to the Idd9.3 region. Immunogenetics. 2006;58:9-14 pubmed
    ..Our work establishes CD137 as a candidate gene for control of autoantibody production in NOD.Idd9.3 congenic mice.
  18. Farber C, Medrano J. Dissection of a genetically complex cluster of growth and obesity QTLs on mouse chromosome 2 using subcongenic intercrosses. Mamm Genome. 2007;18:635-45 pubmed
    ..These data represent a significant advancement toward the identification of mouse chromosome 2 growth and obesity quantitative trait genes...
  19. Banus H, van Kranen H, Mooi F, Hoebee B, Nagelkerke N, Demant P, et al. Genetic control of Bordetella pertussis infection: identification of susceptibility loci using recombinant congenic strains of mice. Infect Immun. 2005;73:741-7 pubmed
    ..Two other loci, Bps-2 and Bps-3, showed genetic interaction and are located on chromosomes 5 and 11. We aim to identify the gene(s) in these regions which modify susceptibility to B. pertussis...
  20. Tötemeyer S, Sheppard M, Lloyd A, Roper D, Dowson C, Underhill D, et al. IFN-gamma enhances production of nitric oxide from macrophages via a mechanism that depends on nucleotide oligomerization domain-2. J Immunol. 2006;176:4804-10 pubmed
    ..This study also shows that the effect of IFN-gamma in restoring inflammatory responses to gram-negative bacteria or bacterial products in mice with defective TLR4 signaling is likely to be due to a response to peptidoglycan, not LPS...
  21. Liu K, Li Q, Yu Y, Liang C, Subramanian S, Zeng Z, et al. Sle3 and Sle5 can independently couple with Sle1 to mediate severe lupus nephritis. Genes Immun. 2007;8:634-45 pubmed
    ..Our results indicate that Sle3 and Sle5 can independently complement with Sle1, through shared and unique mechanisms, to mediate the development of severe autoimmunity...
  22. Schalkwyk L, Fernandes C, Nash M, Kurrikoff K, Vasar E, Koks S. Interpretation of knockout experiments: the congenic footprint. Genes Brain Behav. 2007;6:299-303 pubmed
    ..However, the impact of genetic background should not be simply viewed as a potential confound, but as a unique opportunity to study the broader responses of a system to a specific (genetic) perturbation...
  23. Farber C, Chitwood J, Lee S, Verdugo R, Islas Trejo A, Rincon G, et al. Overexpression of Scg5 increases enzymatic activity of PCSK2 and is inversely correlated with body weight in congenic mice. BMC Genet. 2008;9:34 pubmed publisher
    ..The identification of novel genes is critical to understanding the molecular basis of body weight. Towards this goal, we have identified secretogranin V (Scg5; also referred to as Sgne1), as a candidate gene for growth traits...
  24. Hjelmervik T, Lindqvist A, Petersen K, Johannesson M, Stavrum A, Johansson A, et al. The influence of the NOD Nss1/Idd5 loci on sialadenitis and gene expression in salivary glands of congenic mice. Arthritis Res Ther. 2007;9:R99 pubmed
    ..We investigated the effects of the Nss1 and Idd5 loci on sialadenitis and gene expression in NOD congenic mice. One submandibular salivary gland from each mouse was used for histological analysis of sialadenitis, whereas ..
  25. L hôte D, Serres C, Laissue P, Oulmouden A, Rogel Gaillard C, Montagutelli X, et al. Centimorgan-range one-step mapping of fertility traits using interspecific recombinant congenic mice. Genetics. 2007;176:1907-21 pubmed
    ..Identifying new genes implied in mammalian fertility pathways is a necessary prerequisite for clarifying their molecular grounds and for proposing diagnostic tools for masculine infertilities...
  26. Chiu S, Kim K, Haus K, Espinal G, Millon L, Warden C. Identification of positional candidate genes for body weight and adiposity in subcongenic mice. Physiol Genomics. 2007;31:75-85 pubmed
    ..Analysis of the relative levels of mRNA for B6 and SPRET/Ei in heterozygous congenic mice showed differentially higher expression of the C57BL/6J allele over the SPRET/Ei allele, indicating a cis ..
  27. Cheung Y, Chang N, Cai Y, Bonventi G, MacLeod R, Wither J. Functional interplay between intrinsic B and T cell defects leads to amplification of autoimmune disease in New Zealand black chromosome 1 congenic mice. J Immunol. 2005;175:8154-64 pubmed
    ..Thus, T and B cell defects act in concert to produce and amplify the autoimmune phenotype...
  28. Delahunty K, Shultz K, Gronowicz G, Koczon Jaremko B, Adamo M, Horton L, et al. Congenic mice provide in vivo evidence for a genetic locus that modulates serum insulin-like growth factor-I and bone acquisition. Endocrinology. 2006;147:3915-23 pubmed
    ..b>Congenic mice establish proof of concept of shared genetic determinants for both circulating IGF-I and bone acquisition.
  29. Saless N, Litscher S, Lopez Franco G, Houlihan M, Sudhakaran S, Raheem K, et al. Quantitative trait loci for biomechanical performance and femoral geometry in an intercross of recombinant congenic mice: restriction of the Bmd7 candidate interval. FASEB J. 2009;23:2142-54 pubmed publisher
  30. Durie P, Kent G, Phillips M, Ackerley C. Characteristic multiorgan pathology of cystic fibrosis in a long-living cystic fibrosis transmembrane regulator knockout murine model. Am J Pathol. 2004;164:1481-93 pubmed
    ..We show, for the first time, that long-lived C578L/6J Cftr(-/-) mice develop manifestations of cystic fibrosis-like disease in all pathologically affected organs in the human form of cystic fibrosis...
  31. Charizopoulou N, Jansen S, Dorsch M, Stanke F, Dorin J, Hedrich H, et al. Instability of the insertional mutation in CftrTgH(neoim)Hgu cystic fibrosis mouse model. BMC Genet. 2004;5:6 pubmed
  32. ESTRADA SMITH D, Castellani L, Wong H, Wen P, Chui A, Lusis A, et al. Dissection of multigenic obesity traits in congenic mouse strains. Mamm Genome. 2004;15:14-22 pubmed
    ..When fed an atherogenic diet, several traits associated with metabolic syndrome were observed in the distal MOB congenic, while alterations in plasma lipoproteins were observed in the middle MOB congenic strain...
  33. Blank R, Baldini T, Kaufman M, Bailey S, Gupta R, Yershov Y, et al. Spectroscopically determined collagen Pyr/deH-DHLNL cross-link ratio and crystallinity indices differ markedly in recombinant congenic mice with divergent calculated bone tissue strength. Connect Tissue Res. 2003;44:134-42 pubmed
    ..The data illustrate the importance of material properties in addition to mineral quantity to bone tissue strength...
  34. Demant P. Cancer susceptibility in the mouse: genetics, biology and implications for human cancer. Nat Rev Genet. 2003;4:721-34 pubmed
    ..In future, this unique approach is likely to provide important insights into the pathways of tumour development and might ultimately lead to more effective individually targeted cancer-prevention strategies...
  35. Warden C, Stone S, Chiu S, Diament A, Corva P, Shattuck D, et al. Identification of a congenic mouse line with obesity and body length phenotypes. Mamm Genome. 2004;15:460-71 pubmed
    ..Since a previous study identified human obesity linkage peaking near the centromere, then the B10.UW mice may exhibit obesity due to the homologous gene...
  36. Stylianou I, Christians J, Keightley P, Bunger L, Clinton M, Bulfield G, et al. Genetic complexity of an obesity QTL ( Fob3) revealed by detailed genetic mapping. Mamm Genome. 2004;15:472-81 pubmed
  37. Diament A, Farahani P, Chiu S, Fisler J, Warden C. A novel mouse Chromosome 2 congenic strain with obesity phenotypes. Mamm Genome. 2004;15:452-9 pubmed
    ..We have constructed a new BSB cross and produced congenic mice with obesity phenotypes by marker-directed selection called B6.S- D2Mit194- D2Mit311...
  38. Saito M, Szakall I, Toth R, Kovacs K, Oros M, Prasad V, et al. Mouse striatal transcriptome analysis: effects of oral self-administration of alcohol. Alcohol. 2004;32:223-41 pubmed
  39. Koarada S, Wu Y, Fertig N, Sass D, Nalesnik M, Todd J, et al. Genetic control of autoimmunity: protection from diabetes, but spontaneous autoimmune biliary disease in a nonobese diabetic congenic strain. J Immunol. 2004;173:2315-23 pubmed
  40. Teppner I, Aigner B, Schreiner E, Muller M, Windisch M. Polymorphic microsatellite markers in the outbred CFW and ICR stocks for the generation of speed congenic mice on C57BL/6 background. Lab Anim. 2004;38:406-12 pubmed
    ..Appearance of mutations in outbred mice therefore requires the generation of congenic mice. The aim of this study was the establishment of a list of polymorphic microsatellite markers which can be used ..
  41. Rosen C, Ackert Bicknell C, Adamo M, Shultz K, Rubin J, Donahue L, et al. Congenic mice with low serum IGF-I have increased body fat, reduced bone mineral density, and an altered osteoblast differentiation program. Bone. 2004;35:1046-58 pubmed
    ..The skeletal response to allelic differences in IGF-I expression can also be measured in vivo, using congenic mice. We created a congenic strain with reduced (approximately 20%) circulating IGF-I (C3H...
  42. Karlsson J, Johannesson M, Lindvall T, Wernhoff P, Holmdahl R, Andersson A. Genetic interactions in Eae2 control collagen-induced arthritis and the CD4+/CD8+ T cell ratio. J Immunol. 2005;174:533-41 pubmed
    ..Eae2 congenic mice were bred with mice congenic for the Eae3/Cia5 locus on chromosome 3, previously shown to interact with Eae2...
  43. Turner C, Sun Q, Schriefer J, Pitner N, Price R, Bouxsein M, et al. Congenic mice reveal sex-specific genetic regulation of femoral structure and strength. Calcif Tissue Int. 2003;73:297-303 pubmed
    ..Although the C3H progenitor mice have a smaller Ip than B6 progenitor mice, the congenic mice carrying the C3H segment at Chr 4 had significantly increased Ip in both males and females, giving these mice ..
  44. Diament A, Warden C. Multiple linked mouse chromosome 7 loci influence body fat mass. Int J Obes Relat Metab Disord. 2004;28:199-210 pubmed
    ..Congenic mouse strains contain donor mouse strain DNA in genomes otherwise identical to a background strain. They can be used to identify defined chromosomal regions containing obesity genes with small effects...
  45. Stanford L, Brown R. MHC-congenic mice (C57BL/6J and B6-H-2K) show differences in speed but not accuracy in learning the Hebb-Williams Maze. Behav Brain Res. 2003;144:187-97 pubmed
    ..These results indicate that these two strains show differences in performance in the Hebb-Williams Maze, but do not differ in cognitive ability...
  46. Gyamera Acheampong C, Vasilescu J, Figeys D, Mbikay M. PCSK4-null sperm display enhanced protein tyrosine phosphorylation and ADAM2 proteolytic processing during in vitro capacitation. Fertil Steril. 2010;93:1112-23 pubmed publisher
    ..More investigation is needed to determine how and to what extent these changes might contribute to the loss of fertilizing ability of PCSK4-null sperm. ..
  47. Siggins S, Nguyen N, McCormack M, Vasudevan S, Villani R, Jane S, et al. The Hedgehog receptor Patched1 regulates myeloid and lymphoid progenitors by distinct cell-extrinsic mechanisms. Blood. 2009;114:995-1004 pubmed publisher
    ..These findings have important implications for therapeutics designed to activate the Hh signaling pathway in hematopoietic cells including hematopoietic stem cells. ..
  48. Ting M, Day B, Spanevello M, Boyd A. Activation of ephrin A proteins influences hematopoietic stem cell adhesion and trafficking patterns. Exp Hematol. 2010;38:1087-98 pubmed publisher
  49. Shin Y, Hong C, Lee H, Shin J, Hong S, Park S. NKT cell-dependent regulation of secondary antigen-specific, conventional CD4+ T cell immune responses. J Immunol. 2010;184:5589-94 pubmed publisher
    ..Taken together, these results suggest that NKT cells are critical for the regulation of Ag-specific, conventional CD4(+) T cells during the secondary phase of an adaptive immune response. ..
  50. Adarichev V, Vegvari A, Szabo Z, Kis Toth K, Mikecz K, Glant T. Congenic strains displaying similar clinical phenotype of arthritis represent different immunologic models of inflammation. Genes Immun. 2008;9:591-601 pubmed publisher
    ..Our study supports the idea that each congenic strain represents a different immunologic subtype of PGIA, providing an explanation for the complex etiology and various clinical phenotypes of rheumatoid arthritis. ..
  51. Ang D, Brodnicki T, Jordan M, Wilson W, Silveira P, Gliddon B, et al. Two genetic loci independently confer susceptibility to autoimmune gastritis. Int Immunol. 2007;19:1135-44 pubmed
    ..Here we verified these linkage data by showing that BALB.B6 congenic mice, in which the distal approximately 40 Mb of chromosome 4 was replaced by C57BL/6 DNA, were resistant to ..
  52. Adams C, Yonchek J, Stitzel J. Development of hippocampal alpha7 nicotinic receptors in C3H and DBA/2 congenic mice. Brain Res. 2006;1122:27-35 pubmed
    ..The present study qualitatively examines this question by comparing alpha7 receptor development in congenic mice in which the DBA/2 allele of Chrna7 has been introgressed onto a C3H genetic background and, conversely, the ..
  53. Muramoto G, Russell J, Safi R, Salter A, Himburg H, Daher P, et al. Inhibition of aldehyde dehydrogenase expands hematopoietic stem cells with radioprotective capacity. Stem Cells. 2010;28:523-34 pubmed publisher
    ..Pharmacologic inhibition of ALDH has therapeutic potential as a means to amplify ST-HSCs for transplantation purposes...
  54. Lin Q, Xiu Y, Jiang Y, Tsurui H, Nakamura K, Kodera S, et al. Genetic dissection of the effects of stimulatory and inhibitory IgG Fc receptors on murine lupus. J Immunol. 2006;177:1646-54 pubmed
  55. Ichii O, Kamikawa A, Otsuka S, Hashimoto Y, Sasaki N, Endoh D, et al. Overexpression of interferon-activated gene 202 (Ifi202) correlates with the progression of autoimmune glomerulonephritis associated with the MRL chromosome 1. Lupus. 2010;19:897-905 pubmed publisher
    B6.MRLc1(82-100) congenic mice carrying the telomeric region of lupus-prone MRL chromosome 1 develop autoimmune glomerulonephritis (GN). The GN susceptibility locus of B6...
  56. Bouley D, McIntire J, Harris B, Tolwani R, Otto G, DeKruyff R, et al. Spontaneous murine neuroaxonal dystrophy: a model of infantile neuroaxonal dystrophy. J Comp Pathol. 2006;134:161-70 pubmed
    ..Mouse NAD would therefore seem a potentially valuable model of human NADs...
  57. Ivakine E, Gulban O, Mortin Toth S, Wankiewicz E, Scott C, Spurrell D, et al. Molecular genetic analysis of the Idd4 locus implicates the IFN response in type 1 diabetes susceptibility in nonobese diabetic mice. J Immunol. 2006;176:2976-90 pubmed
  58. Takaku T, Malide D, Chen J, Calado R, Kajigaya S, Young N. Hematopoiesis in 3 dimensions: human and murine bone marrow architecture visualized by confocal microscopy. Blood. 2010;116:e41-55 pubmed publisher
    ..The technique should be generally adaptable for basic laboratory investigation and for clinical diagnosis of hematologic diseases...
  59. Addis Lieser E, Köhl J, Chiaramonte M. Opposing regulatory roles of complement factor 5 in the development of bleomycin-induced pulmonary fibrosis. J Immunol. 2005;175:1894-902 pubmed
    ..Furthermore, these findings provide insight into the development of new therapeutic strategies for idiopathic pulmonary fibrosis patients...
  60. Zimmer M, Nguyen H, Wang B, Xu H, Colmone A, Felio K, et al. Polymorphisms in CD1d affect antigen presentation and the activation of CD1d-restricted T cells. Proc Natl Acad Sci U S A. 2009;106:1909-14 pubmed publisher
    ..Using congenic mice, we found CD1d polymorphisms affect the thymic selection of type I NKT cells and induce allogeneic T cell ..
  61. Peng Y, Latchman Y, Elkon K. Ly6C(low) monocytes differentiate into dendritic cells and cross-tolerize T cells through PDL-1. J Immunol. 2009;182:2777-85 pubmed publisher
    ..These observations demonstrate that Ly6C(low) mature monocytes can promote tolerance to self Ag contained in apoptotic cells through a PDL-1-dependent mechanism...