congenic animals

Summary

Summary: Animals that are produced through selective breeding to eliminate genetic background differences except for a single or few specific loci. They are used to investigate the contribution of genetic background differences to PHENOTYPE.

Top Publications

  1. MacMurray A, Moralejo D, Kwitek A, Rutledge E, Van Yserloo B, Gohlke P, et al. Lymphopenia in the BB rat model of type 1 diabetes is due to a mutation in a novel immune-associated nucleotide (Ian)-related gene. Genome Res. 2002;12:1029-39 pubmed
    ..The lymphopenia mutation may thus be useful not only to elucidate Type 1 diabetes, but also in the function of the Ian gene family as a whole...
  2. Olofsson P, Holmberg J, Tordsson J, Lu S, Akerstrom B, Holmdahl R. Positional identification of Ncf1 as a gene that regulates arthritis severity in rats. Nat Genet. 2003;33:25-32 pubmed
    ..Hence, Ncf1 is associated with a new autoimmune mechanism leading to severe destructive arthritis, notably similar to rheumatoid arthritis in humans...
  3. Moralejo D, Park H, Speros S, MacMurray A, Kwitek A, Jacob H, et al. Genetic dissection of lymphopenia from autoimmunity by introgression of mutated Ian5 gene onto the F344 rat. J Autoimmun. 2003;21:315-24 pubmed
    ..The congenic F344.lyp rat should prove useful to dissect the mechanisms by which the Ian5 frameshift mutation affects T cell selection, differentiation and maturation without organ-specific autoimmunity...
  4. Carr L, Habegger K, Spence J, Liu L, Lumeng L, Foroud T. Development of congenic rat strains for alcohol consumption derived from the alcohol-preferring and nonpreferring rats. Behav Genet. 2006;36:285-90 pubmed
    ..These congenic animals will be an invaluable resource for fine mapping the QTL region and for the identification of the gene(s) that ..
  5. Carr L, Kimpel M, Liang T, McClintick J, McCall K, Morse M, et al. Identification of candidate genes for alcohol preference by expression profiling of congenic rat strains. Alcohol Clin Exp Res. 2007;31:1089-98 pubmed
    ..This study was undertaken to identify genes in the chromosome 4 QTL interval that might contribute to the differences in alcohol consumption between the alcohol-naïve congenic and background strains...
  6. Rangel Filho A, Sharma M, Datta Y, Moreno C, Roman R, Iwamoto Y, et al. RF-2 gene modulates proteinuria and albuminuria independently of changes in glomerular permeability in the fawn-hooded hypertensive rat. J Am Soc Nephrol. 2005;16:852-6 pubmed
  7. Schwartz I, Keh A, Hsu G. Morphology, GluR1 and GRIP-C localization differ in octopus cells of C57BL6 and B6Cast mice. Hear Res. 2002;171:1-12 pubmed
  8. Zinkernagel R. On cross-priming of MHC class I-specific CTL: rule or exception?. Eur J Immunol. 2002;32:2385-92 pubmed
  9. Lee G, Matsushita H, Kitagawa T. Fine chromosomal localization of the mouse Par2 gene that confers resistance against urethane-induction of pulmonary adenomas. Oncogene. 2001;20:3979-85 pubmed
    ..The map information obtained in this study should enable subsequent positional cloning of the Par2 gene...
  10. Dahlke M, Lauth O, Jäger M, Roeseler T, Timrott K, Jackobs S, et al. In vivo depletion of hematopoietic stem cells in the rat by an anti-CD45 (RT7) antibody. Blood. 2002;99:3566-72 pubmed
    ..In contrast, mature B cells are not depleted, but precursors also appear to be eliminated. Overall, the findings suggest that the anti-RT7(a) mAb efficiently depletes early rat hematopoietic stem cells. ..

Detail Information

Publications110 found, 100 shown here

  1. MacMurray A, Moralejo D, Kwitek A, Rutledge E, Van Yserloo B, Gohlke P, et al. Lymphopenia in the BB rat model of type 1 diabetes is due to a mutation in a novel immune-associated nucleotide (Ian)-related gene. Genome Res. 2002;12:1029-39 pubmed
    ..The lymphopenia mutation may thus be useful not only to elucidate Type 1 diabetes, but also in the function of the Ian gene family as a whole...
  2. Olofsson P, Holmberg J, Tordsson J, Lu S, Akerstrom B, Holmdahl R. Positional identification of Ncf1 as a gene that regulates arthritis severity in rats. Nat Genet. 2003;33:25-32 pubmed
    ..Hence, Ncf1 is associated with a new autoimmune mechanism leading to severe destructive arthritis, notably similar to rheumatoid arthritis in humans...
  3. Moralejo D, Park H, Speros S, MacMurray A, Kwitek A, Jacob H, et al. Genetic dissection of lymphopenia from autoimmunity by introgression of mutated Ian5 gene onto the F344 rat. J Autoimmun. 2003;21:315-24 pubmed
    ..The congenic F344.lyp rat should prove useful to dissect the mechanisms by which the Ian5 frameshift mutation affects T cell selection, differentiation and maturation without organ-specific autoimmunity...
  4. Carr L, Habegger K, Spence J, Liu L, Lumeng L, Foroud T. Development of congenic rat strains for alcohol consumption derived from the alcohol-preferring and nonpreferring rats. Behav Genet. 2006;36:285-90 pubmed
    ..These congenic animals will be an invaluable resource for fine mapping the QTL region and for the identification of the gene(s) that ..
  5. Carr L, Kimpel M, Liang T, McClintick J, McCall K, Morse M, et al. Identification of candidate genes for alcohol preference by expression profiling of congenic rat strains. Alcohol Clin Exp Res. 2007;31:1089-98 pubmed
    ..This study was undertaken to identify genes in the chromosome 4 QTL interval that might contribute to the differences in alcohol consumption between the alcohol-naïve congenic and background strains...
  6. Rangel Filho A, Sharma M, Datta Y, Moreno C, Roman R, Iwamoto Y, et al. RF-2 gene modulates proteinuria and albuminuria independently of changes in glomerular permeability in the fawn-hooded hypertensive rat. J Am Soc Nephrol. 2005;16:852-6 pubmed
  7. Schwartz I, Keh A, Hsu G. Morphology, GluR1 and GRIP-C localization differ in octopus cells of C57BL6 and B6Cast mice. Hear Res. 2002;171:1-12 pubmed
  8. Zinkernagel R. On cross-priming of MHC class I-specific CTL: rule or exception?. Eur J Immunol. 2002;32:2385-92 pubmed
  9. Lee G, Matsushita H, Kitagawa T. Fine chromosomal localization of the mouse Par2 gene that confers resistance against urethane-induction of pulmonary adenomas. Oncogene. 2001;20:3979-85 pubmed
    ..The map information obtained in this study should enable subsequent positional cloning of the Par2 gene...
  10. Dahlke M, Lauth O, Jäger M, Roeseler T, Timrott K, Jackobs S, et al. In vivo depletion of hematopoietic stem cells in the rat by an anti-CD45 (RT7) antibody. Blood. 2002;99:3566-72 pubmed
    ..In contrast, mature B cells are not depleted, but precursors also appear to be eliminated. Overall, the findings suggest that the anti-RT7(a) mAb efficiently depletes early rat hematopoietic stem cells. ..
  11. Kernek K, Trofatter J, Mayeda A, Hofstetter J. A locus for circadian period of locomotor activity on mouse proximal chromosome 3. Chronobiol Int. 2004;21:343-52 pubmed
    ..Future studies will focus on identifying the gene influencing period. ..
  12. Mansfield L, Bell J, Wilson D, Murphy A, Elsheikha H, Rathinam V, et al. C57BL/6 and congenic interleukin-10-deficient mice can serve as models of Campylobacter jejuni colonization and enteritis. Infect Immun. 2007;75:1099-115 pubmed
    ..jejuni 11168 is necessary but not sufficient for the development of enteritis and that C57BL/6 IL-10(-/-) mice can serve as models for the study of C. jejuni enteritis in humans. ..
  13. Kuroda R, Endo B, Abe M, Shimizu M. Chiral blastomere arrangement dictates zygotic left-right asymmetry pathway in snails. Nature. 2009;462:790-4 pubmed publisher
    ..Moreover, manipulation reversed the embryonic nodal expression patterns. Using backcrossed F(7) congenic animals, we could demonstrate a strong genetic linkage between the handedness-determining gene(s) and the chiral ..
  14. Shin J, Bossenz M, Chung Y, Ma H, Byron M, Taniguchi Ishigaki N, et al. Maternal Rnf12/RLIM is required for imprinted X-chromosome inactivation in mice. Nature. 2010;467:977-81 pubmed publisher
    ..These results assign crucial functions to the maternal deposit of Rnf12/RLIM for the initiation of imprinted XCI...
  15. Saad Y, Garrett M, Rapp J. Multiple blood pressure QTL on rat chromosome 1 defined by Dahl rat congenic strains. Physiol Genomics. 2001;4:201-14 pubmed
    ..QTL 1b also corresponded approximately with a blood pressure QTL described on human chr 15. The QTL region 2 corresponded approximately with blood pressure QTL described on mouse chr 10 and human chr 6...
  16. Zhang L, Freedman N, Brian L, Peppel K. Graft-extrinsic cells predominate in vein graft arterialization. Arterioscler Thromb Vasc Biol. 2004;24:470-6 pubmed
    ..Cells extrinsic to the graft, including bone marrow-derived cells, predominate during vein graft remodeling. ..
  17. Garrett M, Rapp J. Two closely linked interactive blood pressure QTL on rat chromosome 5 defined using congenic Dahl rats. Physiol Genomics. 2002;8:81-6 pubmed
    ..Neither LEW allele alone had a significant effect on blood pressure. The two QTL were localized to regions 6.3 and 4.6 cM, and these were 1.0 cM apart. ..
  18. Xing Y, Sonner J, Eger E, Cascio M, Sessler D. Mice with a melanocortin 1 receptor mutation have a slightly greater minimum alveolar concentration than control mice. Anesthesiology. 2004;101:544-6 pubmed
  19. Grondin M, Eliopoulos V, Lambert R, Deng Y, Ariyarajah A, Moujahidine M, et al. Complete and overlapping congenics proving the existence of a quantitative trait locus for blood pressure on Dahl rat chromosome 17. Physiol Genomics. 2005;21:112-6 pubmed
    ..L4, and C17S.L5. The present study illustrates the importance of thorough chromosome coverage, the necessity for a genome-wide screening, and the use of "negative" controls in physically mapping a QTL by congenic strains. ..
  20. Behmoaras J, Bhangal G, Smith J, McDonald K, Mutch B, Lai P, et al. Jund is a determinant of macrophage activation and is associated with glomerulonephritis susceptibility. Nat Genet. 2008;40:553-9 pubmed publisher
  21. Samuelson D, Haag J, Lan H, Monson D, Shultz M, Kolman B, et al. Physical evidence of Mcs5, a QTL controlling mammary carcinoma susceptibility, in congenic rats. Carcinogenesis. 2003;24:1455-60 pubmed
    ..Based on results presented here, the Mcs5 locus has been physically located within a congenic interval on rat chromosome 5 between markers D5Uwm8 and D5Rat26. ..
  22. Collins S, Wallis R, Wilder S, Wallace K, Argoud K, Kaisaki P, et al. Mapping diabetes QTL in an intercross derived from a congenic strain of the Brown Norway and Goto-Kakizaki rats. Mamm Genome. 2006;17:538-47 pubmed
  23. Bodnar J, Chatterjee A, Castellani L, Ross D, Ohmen J, Cavalcoli J, et al. Positional cloning of the combined hyperlipidemia gene Hyplip1. Nat Genet. 2002;30:110-6 pubmed
    ..These results reveal a new pathway of potential clinical significance that contributes to plasma lipid metabolism. ..
  24. Palijan A, Lambert R, Dutil J, Sivo Z, Deng A. Comprehensive congenic coverage revealing multiple blood pressure quantitative trait loci on Dahl rat chromosome 10. Hypertension. 2003;42:515-22 pubmed
    ..These QTLs will likely have an influence on studies of human hypertension because of their homology with the human CHR 17 region in which QTLs for BP have been found. ..
  25. Sim B, Holmberg K, Sidobre S, Naidenko O, Niederberger N, Marine S, et al. Surprisingly minor influence of TRAV11 (Valpha14) polymorphism on NK T-receptor mCD1/alpha-galactosylceramide binding kinetics. Immunogenetics. 2003;54:874-83 pubmed
    ..These differences are minor compared with differences between agonist and antagonist ligands in other TCR systems, suggesting that it is unlikely that TCR polymorphism explains the defect in NK T cells in the autoimmune mouse strains. ..
  26. Wallace K, Wallis R, Collins S, Argoud K, Kaisaki P, Ktorza A, et al. Quantitative trait locus dissection in congenic strains of the Goto-Kakizaki rat identifies a region conserved with diabetes loci in human chromosome 1q. Physiol Genomics. 2004;19:1-10 pubmed
  27. Pichugin A, Petrovskaya S, Apt A. H2 complex controls CD4/CD8 ratio, recurrent responsiveness to repeated stimulations, and resistance to activation-induced apoptosis during T cell response to mycobacterial antigens. J Leukoc Biol. 2006;79:739-46 pubmed
    ..These results may shed some light on the nature of the cellular basis of MHC-linked differences in susceptibility to TB. ..
  28. Yokoi N, Hayashi C, Fujiwara Y, Wang H, Seino S. Genetic reconstitution of autoimmune type 1 diabetes with two major susceptibility genes in the rat. Diabetes. 2007;56:506-12 pubmed
    ..The low incidence and delayed onset of the disease strongly suggest involvement of genetic modifiers; the congenic strain established in this study should be useful for the mapping and identification of such modifiers. ..
  29. Nabika T, Kobayashi Y, Yamori Y. Congenic rats for hypertension: how useful are they for the hunting of hypertension genes?. Clin Exp Pharmacol Physiol. 2000;27:251-6 pubmed
    ..4. To make the most of advances in DNA technology, the precise evaluation of the phenotypic difference between congenic strains carrying different QTL or between a congenic and parental strain is critical. ..
  30. Gardner R, McKinnon E, Astle C. Analysis of the stem cell sparing properties of cyclophosphamide. Eur J Haematol. 2001;67:14-22 pubmed
    ..Low-dose cyclophosphamide can spare stem cells, depending upon the timing of subsequent doses. ..
  31. Moujahidine M, Lambert R, Dutil J, Palijan A, Sivo Z, Ariyarajah A, et al. Combining congenic coverage with gene profiling in search of candidates for blood pressure quantitative trait loci in Dahl rats. Hypertens Res. 2004;27:203-12 pubmed
    ..Thus, the present study highlights the importance of correlating the results of gene expression profiling with fine congenic mapping. ..
  32. Waldschmidt T, Panoskaltsis Mortari A, McElmurry R, Tygrett L, Taylor P, Blazar B. Abnormal T cell-dependent B-cell responses in SCID mice receiving allogeneic bone marrow in utero. Severe combined immune deficiency. Blood. 2002;100:4557-64 pubmed
    ..Thus, although allogeneic BM transplantation results in complete recovery of the B-cell compartment, certain elements of the humoral response remain defective. ..
  33. Tsuji A, Sugyo A, Ogiu T, Sagara M, Kimura T, Ishikawa A, et al. Fine mapping of radiation susceptibility and gene expression analysis of LEC congenic rat lines. Genomics. 2005;86:271-9 pubmed
    ..2-Mb region; however, expression analysis gave no clear indication as to which gene is responsible...
  34. BitMansour A, Burns S, Traver D, Akashi K, Contag C, Weissman I, et al. Myeloid progenitors protect against invasive aspergillosis and Pseudomonas aeruginosa infection following hematopoietic stem cell transplantation. Blood. 2002;100:4660-7 pubmed
    ..These results demonstrate that enhanced reconstitution of a tissue myeloid pool offers protection against lethal challenge with serious fungal and bacterial pathogens. ..
  35. Zhou H, Lamont S. Chicken MHC class I and II gene effects on antibody response kinetics in adult chickens. Immunogenetics. 2003;55:133-140 pubmed publisher
    ..enteritidis antibody and Y(max) to SRBC. The results suggest that the characterized SNPs might be used in future applications by marker-assisted selection to improve vaccine response and immunocompetence in chickens. ..
  36. Choi E, Christianson G, Yoshimura Y, Jung N, Sproule T, Malarkannan S, et al. Real-time T-cell profiling identifies H60 as a major minor histocompatibility antigen in murine graft-versus-host disease. Blood. 2002;100:4259-65 pubmed
  37. Visscher P. Speed congenics: accelerated genome recovery using genetic markers. Genet Res. 1999;74:81-5 pubmed
  38. Prockop S, Petrie H. Regulation of thymus size by competition for stromal niches among early T cell progenitors. J Immunol. 2004;173:1604-11 pubmed
    ..Together with asymmetric use of marrow-derived progenitors to reconstitute the intrathymic pool, these processes facilitate continuous generation of new T cells while maintaining a relatively stable organ size. ..
  39. Chen B, Deoliveira D, Cui X, Le N, Son J, Whitesides J, et al. Inability of memory T cells to induce graft-versus-host disease is a result of an abortive alloresponse. Blood. 2007;109:3115-23 pubmed
    ..The abortive immune response, which was mediated by non-alloantigen-specific memory T cells in response to alloantigens, may explain why memory T cells from unprimed and non-alloantigen-primed donors could not induce GVHD. ..
  40. Moralejo D, Hansen C, Treuting P, Hessner M, Fuller J, Van Yserloo B, et al. Differential effects of leptin receptor mutation on male and female BBDR Gimap5-/Gimap5- spontaneously diabetic rats. Physiol Genomics. 2010;41:9-20 pubmed publisher
    ..lepr-/lepr-,Gimap5-/Gimap5-) congenic rats. BBDR.(lepr-/lepr-,Gimap5-/Gimap5-) congenic rats should prove valuable to study interactions between lack of leptin receptor signaling, obesity, and sex-specific T2D and T1D. ..
  41. Cicila G, Choi C, Dene H, Lee S, Rapp J. Two blood pressure/cardiac mass quantitative trait loci on chromosome 3 in Dahl rats. Mamm Genome. 1999;10:112-6 pubmed
  42. Broxmeyer H, Kohli L, Kim C, Lee Y, Mantel C, Cooper S, et al. Stromal cell-derived factor-1/CXCL12 directly enhances survival/antiapoptosis of myeloid progenitor cells through CXCR4 and G(alpha)i proteins and enhances engraftment of competitive, repopulating stem cells. J Leukoc Biol. 2003;73:630-8 pubmed
    ..These results extend information on the survival effects mediated through the SDF-1/CXCL12-CXCR4 axis and may be of relevance for ex vivo expansion and gene-transduction procedures. ..
  43. Bieg S. Differential expression of p95vav in primary lymphoid tissue of BB rats congenic for the lymphopenia gene. Autoimmunity. 1999;30:37-42 pubmed
    ..An increase in the availability of p95vav during the development and activation of thymocytes in Lyp/Lyp BB rats may therefore contribute to the generation of islet autoreactivity, lymphopenia or both...
  44. Hirai H, Zhang P, Dayaram T, Hetherington C, Mizuno S, Imanishi J, et al. C/EBPbeta is required for 'emergency' granulopoiesis. Nat Immunol. 2006;7:732-9 pubmed
    ..C/EBPbeta inhibited proliferation less severely than did C/EBPalpha. These data suggest a critical function for C/EBPbeta in emergency granulopoiesis, which demands both differentiation and proliferation of granulocyte precursors...
  45. Bäckdahl L, Ribbhammar U, Lorentzen J. Mapping and functional characterization of rat chromosome 4 regions that regulate arthritis models and phenotypes in congenic strains. Arthritis Rheum. 2003;48:551-9 pubmed
    ..We produced congenic strains for these QTLs in order to map and characterize their impact on arthritis development...
  46. Mas M, Cavailles P, Colacios C, Subra J, Lagrange D, Calise M, et al. Studies of congenic lines in the Brown Norway rat model of Th2-mediated immunopathological disorders show that the aurothiopropanol sulfonate-induced immunological disorder (Aiid3) locus on chromosome 9 plays a major role compared to Aiid2 on chromos. J Immunol. 2004;172:6354-61 pubmed
    ..Further genetic and functional dissections of these loci should provide insights into pathways that lead to Th2-adverse reactions...
  47. Tripodi G, Florio M, Ferrandi M, Modica R, Zimdahl H, Hubner N, et al. Effect of Add1 gene transfer on blood pressure in reciprocal congenic strains of Milan rats. Biochem Biophys Res Commun. 2004;324:562-8 pubmed
    ..In contrast, SBPs of Add2 and Add3 congenic strains were not different from those of the correspondent recipient parental strain. The fine mapping of chr14 congenic segment supports the identity of blood pressure QTL with Add1 gene...
  48. Angers I, Sancho Shimizu V, Descoteaux A, Gewirtz A, Malo D. Tlr5 is not primarily associated with susceptibility to Salmonella Typhimurium infection in MOLF/Ei mice. Mamm Genome. 2006;17:385-97 pubmed
    ..MOLF-Ity mice, they exhibit a different phenotype with respect to Tlr5 expression and Tlr5 signaling, supporting the prediction that Tlr5 is not primarily involved in the disease phenotype underlying the Ity3 locus in MOLF/Ei mice...
  49. Pang J, Boye S, Kumar A, Dinculescu A, Deng W, Li J, et al. AAV-mediated gene therapy for retinal degeneration in the rd10 mouse containing a recessive PDEbeta mutation. Invest Ophthalmol Vis Sci. 2008;49:4278-83 pubmed publisher
    ..To test AAV-mediated gene therapy in the rd10 mouse, a natural model of recessive RP caused by mutation of the beta-subunit of rod photoreceptor cGMP phosphodiesterase...
  50. Qian Z, Wasowska B, Behrens E, Cangello D, Brody J, Kadkol S, et al. C6 produced by macrophages contributes to cardiac allograft rejection. Am J Pathol. 1999;155:1293-302 pubmed
    ..1U (C6-) donors, C6 levels remained undetectable and PVG.R8 cardiac allografts were not rejected. These results indicate that C6 produced by macrophages can cause significant tissue damage...
  51. Howell J, Yoder M, Srour E. Hematopoietic potential of murine skeletal muscle-derived CD45(-)Sca-1(+)c-kit(-) cells. Exp Hematol. 2002;30:915-24 pubmed
    ..Our goal was to determine the identity of neonatal muscle-derived cells that contain hematopoietic potential and to explore the status of CD45 expression on these cells...
  52. Ariyarajah A, Palijan A, Dutil J, Prithiviraj K, Deng Y, Deng A. Dissecting quantitative trait loci into opposite blood pressure effects on Dahl rat chromosome 8 by congenic strains. J Hypertens. 2004;22:1495-502 pubmed
    ..The current work is to delineate the chromosome interval harboring this QTL by using congenic strains with different chromosome substitutions...
  53. Mullick A, Elias M, Picard S, Bourget L, Jovcevski O, Gauthier S, et al. Dysregulated inflammatory response to Candida albicans in a C5-deficient mouse strain. Infect Immun. 2004;72:5868-76 pubmed
    ..albicans, confirming the causative role of C5 deficiency in the dysregulated cytokine response...
  54. Rubattu S, Hubner N, Ganten U, Evangelista A, Stanzione R, Di Angelantonio E, et al. Reciprocal congenic lines for a major stroke QTL on rat chromosome 1. Physiol Genomics. 2006;27:108-13 pubmed
    ..Our results underscore the functional importance of the Chr 1 stroke QTL. Furthermore, they underscore the utility of stroke/congenic lines in dissecting the genetics of stroke...
  55. Bilusic M, Moreno C, Barreto N, Tschannen M, Harris E, Porteous W, et al. Genetically hypertensive Brown Norway congenic rat strains suggest intermediate traits underlying genetic hypertension. Croat Med J. 2008;49:586-99 pubmed
  56. Pravenec M, Zidek V, Musilova A, Vorlicek J, Kren V, St Lezin E, et al. Genetic isolation of a blood pressure quantitative trait locus on chromosome 2 in the spontaneously hypertensive rat. J Hypertens. 2001;19:1061-4 pubmed
    ..The objective of the current study was to directly test for the presence of a blood pressure QTL on rat chromosome 2...
  57. Olofsson P, Holmberg J, Pettersson U, Holmdahl R. Identification and isolation of dominant susceptibility loci for pristane-induced arthritis. J Immunol. 2003;171:407-16 pubmed
    ..These data highlight the usefulness of the statistical power obtained in a backcross of a complex disease like arthritis...
  58. Barker J, Schuldt A, Lessard M, Jude C, Vogler C, Soper B. Donor cell replacement in mice transplanted in utero is limited by immune-independent mechanisms. Blood Cells Mol Dis. 2003;31:291-7 pubmed
    ..The mechanism limiting initial expansion may differ from that supporting long-term cell retention...
  59. Yagil Y, Yagil C. Congenics in the pathway from quantitative trait loci detection to gene identification: is that the way to go?. J Hypertens. 2003;21:2009-11 pubmed
  60. Wang T, Takabatake T, Kobayashi Y, Nabika T. Sympathetic regulation of renal function in stroke-prone spontaneously hypertensive rats congenic for chromosome 1 blood pressure quantitative trait loci. Clin Exp Pharmacol Physiol. 2008;35:1365-70 pubmed publisher
    ..The reciprocal congenic strains are thereby unique models that may help in the search for intermediate phenotypes and empower functional deduction of candidate genes...
  61. Wiessner J, Garrett M, Roman R, Mandel N. Dissecting the genetic basis of kidney tubule response to hyperoxaluria using chromosome substitution strains. Am J Physiol Renal Physiol. 2009;297:F301-6 pubmed publisher
    ..These observations establish that BN rat chromosome 2 and 18 harbor genes that contribute to these processes...
  62. Gillett A, Marta M, Jin T, Tuncel J, Leclerc P, Nohra R, et al. TNF production in macrophages is genetically determined and regulates inflammatory disease in rats. J Immunol. 2010;185:442-50 pubmed publisher
    ..Determination of genes and mechanisms involved in this genetically determined TNF regulation will be valuable in understanding disease pathogenesis and aid treatment development...
  63. Sivo Z, Malo B, Dutil J, Deng A. Accelerated congenics for mapping two blood pressure quantitative trait loci on chromosome 10 of Dahl rats. J Hypertens. 2002;20:45-53 pubmed
    ..To localize quantitative trait loci (QTL) in an animal model that is potentially relevant to human hypertension...
  64. Lu S, Carlsen S, Hansson A, Holmdahl R. Immunization of rats with homologous type XI collagen leads to chronic and relapsing arthritis with different genetics and joint pathology than arthritis induced with homologous type II collagen. J Autoimmun. 2002;18:199-211 pubmed
    ..Taken together, C(XI)IA is a chronic relapsing and erosive polyarthritis that is MHC associated, which in fact fulfills the criteria for diagnosis of RA. Thus the C(XI)IA model will be useful as a novel and relevant animal model for RA...
  65. Min B, McHugh R, Sempowski G, Mackall C, Foucras G, Paul W. Neonates support lymphopenia-induced proliferation. Immunity. 2003;18:131-40 pubmed
    ..CD44(bright) CD4 T cells in neonates have a wide repertoire as judged by the distribution of Vbeta expression. Thus, lymphopenia-induced T cell proliferation is a physiologic process that occurs during the early postnatal period...
  66. Hall F, Li X, Goeb M, Roff S, Hoggatt H, Sora I, et al. Congenic C57BL/6 mu opiate receptor (MOR) knockout mice: baseline and opiate effects. Genes Brain Behav. 2003;2:114-21 pubmed
  67. Stingl J, Eirew P, Ricketson I, Shackleton M, Vaillant F, Choi D, et al. Purification and unique properties of mammary epithelial stem cells. Nature. 2006;439:993-7 pubmed
    ..The mammary stem cells are also a rapidly cycling population in the normal adult and have molecular features indicative of a basal position in the mammary epithelium...
  68. Drenjancevic Peric I, Weinberg B, Greene A, Lombard J. Restoration of cerebral vascular relaxation in renin congenic rats by introgression of the Dahl R renin gene. Am J Hypertens. 2010;23:243-8 pubmed publisher
    ..SR-(D13N1 and Syt2)/Mcwi) (RGRR) rats maintained on low-salt (0.4% NaCl) diet...
  69. Lagrange D, Fournié G. Generation of congenic and consomic rat strains. Methods Mol Biol. 2010;597:243-66 pubmed publisher
    ..Although their production is lengthy and costly, it only requires a zootechny unit for breeding and tools for genotyping...
  70. Monti J, Zimdahl H, Schulz H, Plehm R, Ganten D, Hubner N. The role of Wnk4 in polygenic hypertension: a candidate gene analysis on rat chromosome 10. Hypertension. 2003;41:938-42 pubmed
    ..Thus, Wnk4 is likely not to represent the underlying disease gene for the QTL captured in chromosome 10 congenic animals.
  71. Diao J, Winter E, Chen W, Cantin C, Cattral M. Characterization of distinct conventional and plasmacytoid dendritic cell-committed precursors in murine bone marrow. J Immunol. 2004;173:1826-33 pubmed
    ..Both DC precursor populations can give rise to CD8 alpha(+) and CD8 alpha(-) DC subtypes. Our findings indicate that CD11c(+)MHC II(-)B220(+) and CD11c(+)MHC II(-)B220(-) bone marrow cells are distinct DC lineage-restricted precursors...
  72. Wandstrat A, Nguyen C, Limaye N, Chan A, Subramanian S, Tian X, et al. Association of extensive polymorphisms in the SLAM/CD2 gene cluster with murine lupus. Immunity. 2004;21:769-80 pubmed
    ..While autoimmunity may be mediated by a combination of genes in the SLAM/CD2 family cluster, the strongest candidate is Ly108, a specific isoform of which is constitutively upregulated in B6.Sle1b lymphocytes...
  73. Meyer B, Bazzi H, Zidek V, Musilova A, Pravenec M, Kurtz T, et al. A spontaneous mutation in the desmoglein 4 gene underlies hypotrichosis in a new lanceolate hair rat model. Differentiation. 2004;72:541-7 pubmed
    ..Further studies on the skin histology in affected rats demonstrated features consistent with a lanceolate hair mutation, providing further support for the crucial role of desmoglein 4 in hair shaft differentiation...
  74. Rintisch C, Ameri J, Olofsson P, Luthman H, Holmdahl R. Positional cloning of the Igl genes controlling rheumatoid factor production and allergic bronchitis in rats. Proc Natl Acad Sci U S A. 2008;105:14005-10 pubmed publisher
    ..In addition, RF congenic rats had a significantly enhanced immune response toward OVA due to increased OVA-Igk but not OVA-Igl antibodies, suggesting a possible involvement of RF in the regulation of the humoral immune response...
  75. Gilibert S, Bataillard A, Nussberger J, Sassard J, Kwitek A. Implication of chromosome 13 on hypertension and associated disorders in Lyon hypertensive rats. J Hypertens. 2009;27:1186-93 pubmed
    ..Previous genetic mapping identified quantitative trait loci (QTLs) influencing blood pressure (BP) on rat chromosome 13 (RNO13) in several models of hypertension...
  76. Shao H, Sinasac D, Burrage L, Hodges C, Supelak P, Palmert M, et al. Analyzing complex traits with congenic strains. Mamm Genome. 2010;21:276-86 pubmed publisher
    ..Sequential analysis rigorously resolved phenotypic heterogeneity among strains in the congenic panels and found QTLs that other methods failed to detect...
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    ..008). In conclusion, the development of Type 1 diabetes in the congenic DR(lyp/lyp) rat is controlled by at least three genes: lymphopenia, MHC, and a third factor that may play a role in metabolism and body weight regulation...
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    ..Further studies showed that this condition is mediated by the combined impact of acquired and innate immune systems. Our results indicate that PGN exerts a central role in joint inflammation triggered by S. aureus...
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    ..The identification of these independent loci within the Mcs1 COP allele provide a model of the genetic complexity of cancer...
  80. Potenza M, Brodkin E, Joe B, Luo X, Remmers E, Wilder R, et al. Genomic regions controlling corticosterone levels in rats. Biol Psychiatry. 2004;55:634-41 pubmed
    ..The identification of genetic factors controlling stress-responsiveness should advance the understanding of susceptibility to psychiatric illness...
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    ..6S and SHR compared with BB/OK favouring Yy1 and Pref-1 as candidate genes. All other genes were differently expressed according to gender and strain...
  82. Charron S, Duong C, Ménard A, Roy J, Eliopoulos V, Lambert R, et al. Epistasis, not numbers, regulates functions of clustered Dahl rat quantitative trait loci applicable to human hypertension. Hypertension. 2005;46:1300-8 pubmed
    ..The epistatic and additive interactions uncovered in the animal model will help elucidate similar interactions playing a role in human essential hypertension...
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    ..We demonstrated for the first time that the congenic strategy is useful to investigate the effects of genetic hypertension on focal ischemia or stroke...
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    ..e., the Ace allele of the normotensive Wistar-Kyoto (WKY) rat, in the hypertensive background of stroke-prone spontaneously hypertensive (SHRSP) rats...
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    ..The results demonstrate that both MHC and non-MHC genes influence experimental neuropathic pain in rats and also suggest that allelic variation contained in the RT1(av1) haplotype on the PVG background protects against neuropathic pain...
  86. Bunting K, Bradley H, Hawley T, Moriggl R, Sorrentino B, Ihle J. Reduced lymphomyeloid repopulating activity from adult bone marrow and fetal liver of mice lacking expression of STAT5. Blood. 2002;99:479-87 pubmed
    ..These results demonstrate that a significant proportion of the growth factor signals required for multilineage reconstitution potential of HSCs is STAT5 dependent...
  87. Clark L, Greenbaum C, Jiang J, Lernmark A, Ochs H. The antibody response to bacteriophage is linked to the lymphopenia gene in congenic BioBreeding rats. FEMS Immunol Med Microbiol. 2002;32:205-9 pubmed
    ..006) and +/+ (100+/-20; n=7; P=0.004) BB rats. We suggest that the secondary antibody response to the T cell-dependent neoantigen PhiX174 is linked in a recessive manner to genetic factor(s) in the Lyp gene region...
  88. Masui N, Nishikawa T, Takagi Y, Kimura H, Mori M, Yokose S, et al. Establishment of a set of combined immunodeficient DA/Slc-Foxn1(rnu) Lyst(bg) congenic rat strains. Exp Anim. 2004;53:399-407 pubmed
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    ..Murine and human transplant results were compared with a math model for survival advantage of donor peripheral blood cells produced by steady-state chimeric marrow...
  90. Saad Y, Yerga Woolwine S, Saikumar J, Farms P, Manickavasagam E, Toland E, et al. Congenic interval mapping of RNO10 reveals a complex cluster of closely-linked genetic determinants of blood pressure. Hypertension. 2007;50:891-8 pubmed
    ..Because all of these genetic elements are located within a 1.06-Mb region of RNO10, our study has revealed a remarkable insight into a genomic module comprising very closely-linked, opposing genetic determinants of BP...