naegleria

Summary

Summary: A free-living soil amoeba pathogenic to humans and animals. It occurs also in water and sewage. The most commonly found species in man is NAEGLERIA FOWLERI which is the pathogen for primary amebic meningoencephalitis in primates.

Top Publications

  1. De Jonckheere J. Molecular identification of free-living amoebae of the Vahlkampfiidae and Acanthamoebidae isolated in Arizona (USA). Eur J Protistol. 2007;43:9-15 pubmed
    ..8S and ITS2 rDNA. With this molecular method three Naegleria spp. were identified, N. gruberi sensu stricto, N. australiensis and N. tihangensis...
  2. Pelandakis M, Serre S, Pernin P. Analysis of the 5.8S rRNA gene and the internal transcribed spacers in Naegleria spp. and in N. fowleri. J Eukaryot Microbiol. 2000;47:116-21 pubmed
    Internal transcribed spacers (ITS) and the 5.8S ribosomal gene of 21 Naegleria fowleri strains and eight other species including Naegleria gruberi were sequenced...
  3. Pélandakis M, Pernin P. Use of multiplex PCR and PCR restriction enzyme analysis for detection and exploration of the variability in the free-living amoeba Naegleria in the environment. Appl Environ Microbiol. 2002;68:2061-5 pubmed
    A multiplex PCR was developed to simultaneously detect Naegleria fowleri and other Naegleria species in the environment. Multiplex PCR was also capable of identifying N...
  4. De Jonckheere J. Isolation and molecular identification of free-living amoebae of the genus Naegleria from Arctic and sub-Antarctic regions. Eur J Protistol. 2006;42:115-23 pubmed
    ..Morphological analysis of the cysts identified all 11 isolates as belonging to the genus Naegleria, although only about half of them (45%) transformed into flagellates...
  5. Huang S, Hsu B. Survey of Naegleria and its resisting bacteria-Legionella in hot spring water of Taiwan using molecular method. Parasitol Res. 2010;106:1395-402 pubmed publisher
    b>Naegleria is a free-living amoebae existing in soil and aquatic environments. Within the genus Naegleria, N. fowleri is most recognized as potential human pathogen causing primary amoebic meningoencephalitis (PAM)...
  6. Tibayrenc M, Kjellberg F, Ayala F. A clonal theory of parasitic protozoa: the population structures of Entamoeba, Giardia, Leishmania, Naegleria, Plasmodium, Trichomonas, and Trypanosoma and their medical and taxonomical consequences. Proc Natl Acad Sci U S A. 1990;87:2414-8 pubmed
    ..Uniparental reproduction renders unsatisfactory Linnean taxonomy; this needs to be supplemented by the "natural clone" as an additional taxonomic unit, which is best defined by means of genetic markers...
  7. Walsh C. The role of actin, actomyosin and microtubules in defining cell shape during the differentiation of Naegleria amebae into flagellates. Eur J Cell Biol. 2007;86:85-98 pubmed
    Differentiation of Naegleria amebae into flagellates was used to examine the interaction between actin, actomyosin and microtubules in defining cell shape...
  8. Rasmussen J, Cursaro M, Froscio S, Saint C. An examination of the antibiotic effects of cylindrospermopsin on common gram-positive and gram-negative bacteria and the protozoan Naegleria lovaniensis. Environ Toxicol. 2008;23:36-43 pubmed publisher
    ..b>Naegleria lovaniensis, a phagotrophic protozoan, was more susceptible to cylindrospermopsin, with a decrease in the number ..
  9. Fritz Laylin L, Prochnik S, Ginger M, Dacks J, Carpenter M, Field M, et al. The genome of Naegleria gruberi illuminates early eukaryotic versatility. Cell. 2010;140:631-42 pubmed publisher
    ..The free-living amoeboflagellate Naegleria gruberi belongs to a varied and ubiquitous protist clade (Heterolobosea) that diverged from other eukaryotic ..

More Information

Publications103 found, 100 shown here

  1. Fritz Laylin L, Assaf Z, Chen S, Cande W. Naegleria gruberi de novo basal body assembly occurs via stepwise incorporation of conserved proteins. Eukaryot Cell. 2010;9:860-5 pubmed publisher
    ..b>Naegleria gruberi, a unicellular eukaryote, grows as an amoeba that lacks a cytoplasmic microtubule cytoskeleton...
  2. Fritz Laylin L, Ginger M, WALSH C, Dawson S, Fulton C. The Naegleria genome: a free-living microbial eukaryote lends unique insights into core eukaryotic cell biology. Res Microbiol. 2011;162:607-18 pubmed publisher
    b>Naegleria gruberi, a free-living protist, has long been treasured as a model for basal body and flagellar assembly due to its ability to differentiate from crawling amoebae into swimming flagellates...
  3. Opperdoes F, De Jonckheere J, Tielens A. Naegleria gruberi metabolism. Int J Parasitol. 2011;41:915-24 pubmed publisher
    The completion of the genome project for Naegleria gruberi provides a unique insight into the metabolic capacities of an organism, for which there is an almost complete lack of experimental data...
  4. Jabri E, Cech T. In vitro selection of the Naegleria GIR1 ribozyme identifies three base changes that dramatically improve activity. RNA. 1998;4:1481-92 pubmed
    ..Overall, our findings show that variants of the Naegleria GIR1 ribozyme with dramatically improved activity lie very close to the natural GIR1 in sequence space...
  5. De Jonckheere J, Brown S, Dobson P, Robinson B, Pernin P. The amoeba-to-flagellate transformation test is not reliable for the diagnosis of the genus Naegleria. Description of three new Naegleria spp. Protist. 2001;152:115-21 pubmed
    ..failed consistently to transform into flagellates, although they display all other characteristics of the genus Naegleria. When changing the standard transformation test, flagellates were produced...
  6. Robinson B, Monis P, Dobson P. Rapid, sensitive, and discriminating identification of Naegleria spp. by real-time PCR and melting-curve analysis. Appl Environ Microbiol. 2006;72:5857-63 pubmed
    The free-living amoeboflagellate genus Naegleria includes one pathogenic and two potentially pathogenic species (Naegleria fowleri, Naegleria italica, and Naegleria australiensis) plus numerous benign organisms...
  7. Tang Y, Nielsen H, Birgisdottir A, Johansen S. A natural fast-cleaving branching ribozyme from the amoeboflagellate Naegleria pringsheimi. RNA Biol. 2011;8:997-1004 pubmed publisher
    ..GIR1 known from the myxomycete Didymium iridis whereas the large number of GIR1s found in the amoeboflagellate Naegleria has remained largely uncharacterized...
  8. Tyson J, Pearce M, Vargas P, Bagchi S, Mulhern B, Cianciotto N. Multiple Legionella pneumophila Type II secretion substrates, including a novel protein, contribute to differential infection of the amoebae Acanthamoeba castellanii, Hartmannella vermiformis, and Naegleria lovaniensis. Infect Immun. 2013;81:1399-410 pubmed publisher
    ..of an lspF mutant lacking the T2S apparatus documented that T2S is also critical for infection of the amoeba Naegleria lovaniensis. Mutants lacking SrnA, PlaC, or ProA, but not those deficient for NttA, were defective in N...
  9. Shea D, Walsh C. mRNAs for alpha- and beta-tubulin and flagellar calmodulin are among those coordinately regulated when Naegleria gruberi amebae differentiate into flagellates. J Cell Biol. 1987;105:1303-9 pubmed
    Three of four mRNAs that are specific to the differentiation of Naegleria gruberi amebae into flagellates (Mar, J., J. H. Lee, D. Shea, and C. J. Walsh, 1986, J. Cell Biol...
  10. De Jonckheere J, Brown S. Three different group I introns in the nuclear large subunit ribosomal DNA of the amoeboflagellate Naegleria. Nucleic Acids Res. 1998;26:456-61 pubmed
    We have amplified the large subunit ribosomal DNA (LSUrDNA) of the 12 described Naegleria spp. and of 34 other Naegleria lineages that might be distinct species...
  11. Suh M, Han J, No Y, Lee J. Transient concentration of a gamma-tubulin-related protein with a pericentrin-related protein in the formation of basal bodies and flagella during the differentiation of Naegleria gruberi. Cell Motil Cytoskeleton. 2002;52:66-81 pubmed
    The distribution of two proteins in Naegleria gruberi, N-gammaTRP (Naegleria gamma-tubulin-related protein) and N-PRP (Naegleria pericentrin-related protein), was examined during the de novo formation of basal bodies and flagella that ..
  12. Declerck P, Behets J, Delaedt Y, Margineanu A, Lammertyn E, Ollevier F. Impact of non-Legionella bacteria on the uptake and intracellular replication of Legionella pneumophila in Acanthamoeba castellanii and Naegleria lovaniensis. Microb Ecol. 2005;50:536-49 pubmed
    ..pneumophila serogroup 1 by the amoebae Acanthamoeba castellanii and Naegleria lovaniensis. We also investigated their possible influence on the intracellular replication of L...
  13. Chung S, Kang S, Paik S, Lee J. NgUNC-119, Naegleria homologue of UNC-119, localizes to the flagellar rootlet. Gene. 2007;389:45-51 pubmed
    ..We cloned and characterized a homologue of unc-119 from the ameboflagellate Naegleria gruberi (Ngunc-119) and identified the cellular distribution of the protein...
  14. Debnath A, Tunac J, Galindo Gómez S, Silva Olivares A, Shibayama M, McKerrow J. Corifungin, a new drug lead against Naegleria, identified from a high-throughput screen. Antimicrob Agents Chemother. 2012;56:5450-7 pubmed publisher
    Primary amebic meningoencephalitis (PAM) is a rapidly fatal infection caused by the free-living ameba Naegleria fowleri...
  15. Hashimoto H, Pais J, Zhang X, Saleh L, Fu Z, Dai N, et al. Structure of a Naegleria Tet-like dioxygenase in complex with 5-methylcytosine DNA. Nature. 2014;506:391-5 pubmed publisher
    ..of dioxygenases is widely distributed across the tree of life, including in the heterolobosean amoeboflagellate Naegleria gruberi. The genome of Naegleria encodes homologues of mammalian DNA methyltransferase and Tet proteins...
  16. Chung S, Cho J, Cheon H, Paik S, Lee J. Cloning and characterization of a divergent alpha-tubulin that is expressed specifically in dividing amebae of Naegleria gruberi. Gene. 2002;293:77-86 pubmed
    A novel alpha-tubulin gene (alpha6) was cloned from a genomic library of Naegleria gruberi strain NB-1 and characterized...
  17. De Jonckheere J. Molecular definition and the ubiquity of species in the genus Naegleria. Protist. 2004;155:89-103 pubmed
    To investigate the variability within species of the genus Naegleria, the ITS1,5.8S and ITS2 rDNA were sequenced of several strains of N. lovaniensis and its Western Australian variants, N. australiensis, N. fowleri, N. andersoni, N...
  18. Kim H, Kang J, Yumura S, Walsh C, Cho J, Lee J. De novo formation of basal bodies in Naegleria gruberi: regulation by phosphorylation. J Cell Biol. 2005;169:719-24 pubmed
    The de novo formation of basal bodies in Naegleria gruberi was preceded by the transient formation of a microtubule (MT)-nucleating complex containing gamma-tubulin, pericentrin, and myosin II complex (GPM complex)...
  19. Declerck P, Behets J, de Keersmaecker B, Ollevier F. Receptor-mediated uptake of Legionella pneumophila by Acanthamoeba castellanii and Naegleria lovaniensis. J Appl Microbiol. 2007;103:2697-703 pubmed
    Investigation of the attachment and uptake of Legionella pneumophila by Acanthamoeba castellanii and Naegleria lovaniensis, as these are two critical steps in the subsequent bacterial survival in both amoeba hosts.
  20. Edagawa A, Kimura A, Kawabuchi Kurata T, Kusuhara Y, Karanis P. Isolation and genotyping of potentially pathogenic Acanthamoeba and Naegleria species from tap-water sources in Osaka, Japan. Parasitol Res. 2009;105:1109-17 pubmed publisher
    ..and polymerase chain reaction and sequence analysis were then performed to define the species of the detected Naegleria and Acanthamoeba isolates. A total of 257 of 374 samples (68...
  21. Cervantes Sandoval I, Jesús Serrano Luna J, Pacheco Yepez J, Silva Olivares A, Tsutsumi V, Shibayama M. Differences between Naegleria fowleri and Naegleria gruberi in expression of mannose and fucose glycoconjugates. Parasitol Res. 2010;106:695-701 pubmed publisher
    b>Naegleria fowleri is the etiologic agent of primary amoebic meningoencephalitis, a rapidly fatal parasitic disease of humans...
  22. Jamerson M, da Rocha Azevedo B, Cabral G, Marciano Cabral F. Pathogenic Naegleria fowleri and non-pathogenic Naegleria lovaniensis exhibit differential adhesion to, and invasion of, extracellular matrix proteins. Microbiology. 2012;158:791-803 pubmed publisher
    b>Naegleria fowleri and Naegleria lovaniensis are closely related free-living amoebae found in the environment. N. fowleri causes primary amoebic meningoencephalitis (PAM), a rapidly fatal disease of the central nervous system, while N...
  23. Kao P, Tung M, Hsu B, Hsueh C, Chiu Y, Chen N, et al. Occurrence and distribution of Naegleria species from thermal spring environments in Taiwan. Lett Appl Microbiol. 2013;56:1-7 pubmed publisher
    b>Naegleria spp. is a free-living amoeba that can be found in the natural environment. A number of Naegleria spp...
  24. Haugen P, De Jonckheere J, Johansen S. Characterization of the self-splicing products of two complex Naegleria LSU rDNA group I introns containing homing endonuclease genes. Eur J Biochem. 2002;269:1641-9 pubmed
    The two group I introns Nae.L1926 and Nmo.L2563, found at two different sites in nuclear LSU rRNA genes of Naegleria amoebo-flagellates, have been characterized in vitro...
  25. Sheehan K, Fagg J, Ferris M, Henson J. PCR detection and analysis of the free-living amoeba Naegleria in hot springs in Yellowstone and Grand Teton National Parks. Appl Environ Microbiol. 2003;69:5914-8 pubmed
    ..different hot springs in Yellowstone and Grand Teton National Parks, we used PCR with primer sets specific for Naegleria to detect three sequence types that represent species not previously described, as well as a fourth sequence ..
  26. Zhou L, Sriram R, Visvesvara G, Xiao L. Genetic variations in the internal transcribed spacer and mitochondrial small subunit rRNA gene of Naegleria spp. J Eukaryot Microbiol. 2003;50 Suppl:522-6 pubmed
    b>Naegleria spp. are widely distributed free-living amebas, but one species in the genus, N. fowleri, causes acute fulminant primary amebic meningoencephalitis in humans and other animals. Thus, it is important to differentiate N...
  27. Preston T, King C. Locomotion and phenotypic transformation of the amoeboflagellate Naegleria gruberi at the water-air interface. J Eukaryot Microbiol. 2003;50:245-51 pubmed
    The protozoon Naegleria gruberi is able to carry out amoeboid locomotion at the water-air interface in a manner indistinguishable from that exhibited on solid substrata with the production of focal contacts and associated filopodia...
  28. Visvesvara G, De Jonckheere J, Marciano Cabral F, Schuster F. Morphologic and molecular identification of Naegleria dunnebackei n. sp. isolated from a water sample. J Eukaryot Microbiol. 2005;52:523-31 pubmed
    b>Naegleria dunnebackei n. sp., a new species of the free-living amoeboflagellate Naegleria, is described in this report...
  29. Wikmark O, Einvik C, De Jonckheere J, Johansen S. Short-term sequence evolution and vertical inheritance of the Naegleria twin-ribozyme group I intron. BMC Evol Biol. 2006;6:39 pubmed
    Ribosomal DNA of several species of the free-living Naegleria amoeba harbors an optional group I intron within the nuclear small subunit ribosomal RNA gene. The intron (Nae...
  30. Leiva B, Clasdotter E, Linder E, Winiecka Krusnell J. Free-living Acanthamoeba and Naegleria spp. amebae in water sources of León, Nicaragua. Rev Biol Trop. 2008;56:439-46 pubmed
    ..The aims of this study were to evaluate the prevalence of potentially pathogenic Acanthamoeba spp. and Naegleria spp. in different water sources to which the population of Le6n municipality is exposed...
  31. Init I, Lau Y, Arin Fadzlun A, Foead A, Neilson R, Nissapatorn V. Detection of free living amoebae, Acanthamoeba and Naegleria, in swimming pools, Malaysia. Trop Biomed. 2010;27:566-77 pubmed
    This study reports the detection of Acanthamoeba and Naegleria species in 14 swimming pools around Petaling Jaya and Kuala Lumpur, Malaysia...
  32. Grimm D, Ludwig W, Brandt B, Michel R, Schleifer K, Hacker J, et al. Development of 18S rRNA-targeted oligonucleotide probes for specific detection of Hartmannella and Naegleria in Legionella-positive environmental samples. Syst Appl Microbiol. 2001;24:76-82 pubmed
    ..to distinct regions of the 18S rRNA of the Legionella host organisms of the genera Hartmannella and Naegleria. The specificity of the probes, HART498 and NAEG1088, was tested by in situ hybridization of various laboratory ..
  33. Johansen S, Einvik C, Nielsen H. DiGIR1 and NaGIR1: naturally occurring group I-like ribozymes with unique core organization and evolved biological role. Biochimie. 2002;84:905-12 pubmed
    ..The Didymium GIR1 (DiGIR1) and Naegleria GIR1 (NaGIR1) share fundamental features in structural organization and reactivity, and display significant ..
  34. Maruyama S, Nozaki H. Sequence and intranuclear location of the extrachromosomal rDNA plasmid of the amoebo-flagellate Naegleria gruberi. J Eukaryot Microbiol. 2007;54:333-7 pubmed
    ..genomes have distinctive organization of rDNA on extrachromosomal molecules: the rDNAs of the amoebo-flagellate Naegleria gruberi (Heterolobosea) are encoded on an extrachromosomal circular plasmid...
  35. Serrano Luna J, Cervantes Sandoval I, Tsutsumi V, Shibayama M. A biochemical comparison of proteases from pathogenic naegleria fowleri and non-pathogenic Naegleria gruberi. J Eukaryot Microbiol. 2007;54:411-7 pubmed
    b>Naegleria fowleri is the etiologic agent of primary amoebic meningoencephalitis (PAM). Proteases have been suggested to be involved in tissue invasion and destruction during infection...
  36. Rüdinger M, Fritz Laylin L, Polsakiewicz M, Knoop V. Plant-type mitochondrial RNA editing in the protist Naegleria gruberi. RNA. 2011;17:2058-62 pubmed publisher
    ..gene family of such plant-like PPR proteins of the DYW-type was recently discovered in the genome of the protist Naegleria gruberi. This raised the possibility that plant-like RNA editing may occur in this amoeboflagellate...
  37. Behets J, Declerck P, Delaedt Y, Verelst L, Ollevier F. Quantitative detection and differentiation of free-living amoeba species using SYBR green-based real-time PCR melting curve analysis. Curr Microbiol. 2006;53:506-9 pubmed
    ..Distinctive characteristics were found for Naegleria fowleri, N. lovaniensis, N. australiensis, N. gruberi, Hartmanella vermiformis, and Willaertia magna...
  38. González Robles A, Castañón G, Cristóbal Ramos A, Hernández Ramírez V, Omaña Molina M, Martinez Palomo A. Cell surface differences of Naegleria fowleri and Naegleria lovaniensis exposed with surface markers. Exp Parasitol. 2007;117:399-404 pubmed
    Differences in the distribution of diverse cell surface coat markers were found between Naegleria fowleri and Naegleria lovaniensis...
  39. Maciver S. Asexual Amoebae Escape Muller's Ratchet through Polyploidy. Trends Parasitol. 2016;32:855-862 pubmed publisher
    While some amoebae reproduce sexually, many amoebae (e.g., Acanthamoeba, Naegleria) reproduce asexually and therefore, according to popular doctrine, are likely to have been genetically disadvantaged as a consequence...
  40. Miller H, Morgan M, Wylie J, Kaksonen A, Sutton D, Braun K, et al. Elimination of Naegleria fowleri from bulk water and biofilm in an operational drinking water distribution system. Water Res. 2017;110:15-26 pubmed publisher
    ..The need for understanding disinfectant regimes capable of eliminating the causative microorganism, Naegleria fowleri, from bulk water and pipe wall biofilms is critical...
  41. Sohn H, Kang H, Seo G, Kim J, Jung S, Shin H. Efficient Liquid Media for Encystation of Pathogenic Free-Living Amoebae. Korean J Parasitol. 2017;55:233-238 pubmed publisher
    Pathogenic Naegleria fowleri, Acanthamoeba castellanii, and Acanthamoeba polyphaga, are distributed worldwide...
  42. Dunnebacke T. The Zoology Department at Washington University (1944-1954): from undergraduate to graduate studies with Viktor Hamburger. Int J Dev Neurosci. 2001;19:133-8 pubmed
    ..Now, on this occasion of his 100th birthday, I wish to express my appreciation to the Chairman, Dr. Viktor Hamburger, for his teachings, his encouragement, and his friendship that has lasted over the past 56 years. ..
  43. Siddiqui R, Ali I, Cope J, Khan N. Biology and pathogenesis of Naegleria fowleri. Acta Trop. 2016;164:375-394 pubmed publisher
    b>Naegleria fowleri is a protist pathogen that can cause lethal brain infection. Despite decades of research, the mortality rate related with primary amoebic meningoencephalitis owing to N. fowleri remains more than 90%...
  44. Mazzola M, de Bruijn I, Cohen M, Raaijmakers J. Protozoan-induced regulation of cyclic lipopeptide biosynthesis is an effective predation defense mechanism for Pseudomonas fluorescens. Appl Environ Microbiol. 2009;75:6804-11 pubmed publisher
    ..predation as, compared to CLP-deficient mutants, strains SS101 and SBW25 exhibited resistance to grazing by Naegleria americana in vitro and superior persistence in soil in the presence of this bacterial predator...
  45. Niyyati M, Lasjerdi Z, Nazar M, Haghighi A, Nazemalhosseini Mojarad E. Screening of recreational areas of rivers for potentially pathogenic free-living amoebae in the suburbs of Tehran, Iran. J Water Health. 2012;10:140-6 pubmed publisher
    A survey was conducted to determine the presence of free-living amoebae (FLA), especially Acanthamoeba and Naegleria, in river recreation areas in Tehran Province, Iran...
  46. Loo C, Lam N, Yu D, Su X, Lu F. Artemisinin and its derivatives in treating protozoan infections beyond malaria. Pharmacol Res. 2017;117:192-217 pubmed publisher
    ..Trypanosoma spp., Toxoplasma gondii, Neospora caninum, Eimeria tenella, Acanthamoeba castellanii, Naegleria fowleri, Cryptosporidium parvum, Giardia lamblia, and Babesia spp...
  47. Yang J, Harding T, Kamikawa R, Simpson A, Roger A. Mitochondrial Genome Evolution and a Novel RNA Editing System in Deep-Branching Heteroloboseids. Genome Biol Evol. 2017;9:1161-1174 pubmed publisher
    ..Their gene contents were similar to that of Naegleria. In BB2, mitochondrially encoded RNAs were heavily edited, with ?500 mononucleotide insertion events, mostly ..
  48. Xue J, Lamar F, Zhang B, Lin S, Lamori J, Sherchan S. Quantitative assessment of Naegleria fowleri and fecal indicator bacteria in brackish water of Lake Pontchartrain, Louisiana. Sci Total Environ. 2018;622-623:8-16 pubmed publisher
    Brackish water samples from Lake Pontchartrain in Louisiana were assessed for the presence of pathogenic amoeba Naegleria fowleri, which causes primary amoebic meningoencephalitis (PAM)...
  49. Kao P, Tung M, Hsu B, Chou M, Yang H, She C, et al. Quantitative detection and identification of Naegleria spp. in various environmental water samples using real-time quantitative PCR assay. Parasitol Res. 2013;112:1467-74 pubmed publisher
    b>Naegleria spp. is a free-living amoeba that can be found in various aquatic environments. There are some Naegleria spp...
  50. Dykova I, Kyselová I, Pecková H, Obornik M, Lukes J. Identity of Naegleria strains isolated from organs of freshwater fishes. Dis Aquat Organ. 2001;46:115-21 pubmed
    Eighteen Naegleria strains were isolated from organs of freshwater fishes belonging to 5 species...
  51. Cope J, Ali I. Primary Amebic Meningoencephalitis: What Have We Learned in the Last 5 Years?. Curr Infect Dis Rep. 2016;18:31 pubmed publisher
    ..meningoencephalitis (PAM) is a devastating infection of the brain caused by the thermophilic free-living ameba, Naegleria fowleri...
  52. Robinson B, Monis P, Henderson M, Gelonese S, Ferrante A. Detection and significance of the potentially pathogenic amoeboflagellate Naegleria italica in Australia. Parasitol Int. 2004;53:23-7 pubmed
    Thermophilic amoeboflagellates in the genus Naegleria include both virulent and benign species. One of the less studied species, N...
  53. Ithoi I, Ahmad A, Mak J, Nissapatorn V, Lau Y, Mahmud R. Morphological characteristics of developmental stages of Acanthamoeba and Naegleria species before and after staining by various techniques. Southeast Asian J Trop Med Public Health. 2011;42:1327-38 pubmed
    ..the best color and contrast for staining the developmental stages of free living pathogenic Acanthamoeba and Naegleria species...
  54. Trimbur G, Goeckeler J, Brodsky J, Walsh C. Cloning, sequencing, and nucleolar targeting of the basal-body-binding nucleolar protein BN46/51. J Cell Sci. 1999;112 ( Pt 8):1159-68 pubmed
    BN46/51 is an acidic protein found in the granular component of the nucleolus of the amebo-flagellate Naegleria gruberi...
  55. De Jonckheere J. The isolation of Naegleria italica from Peru indicates that this potentially pathogenic species occurs worldwide. Parasitol Int. 2005;54:173-5 pubmed
    The amoeboflagellate genus Naegleria includes a few species that are virulent in experimental animals. One of these species, Naegleria italica, has been isolated from the environment only in Italy and Australia...
  56. Linam W, Ahmed M, Cope J, Chu C, Visvesvara G, da Silva A, et al. Successful treatment of an adolescent with Naegleria fowleri primary amebic meningoencephalitis. Pediatrics. 2015;135:e744-8 pubmed publisher
    b>Naegleria fowleri is a thermophilic, free-living ameba that causes primary amebic meningoencephalitis. The infections are nearly always fatal. We present the third well-documented survivor of this infection in North America...
  57. Knoop V, Rüdinger M. DYW-type PPR proteins in a heterolobosean protist: plant RNA editing factors involved in an ancient horizontal gene transfer?. FEBS Lett. 2010;584:4287-91 pubmed publisher
    ..We here report the first case of DYW-type PLS proteins outside of the plant kingdom in the protist Naegleria gruberi and hypothesize on horizontal gene transfer in very early land plant evolution.
  58. Leduc A, Gravel S, Abikhzer J, Roy S, Barbeau J. Polymerase chain reaction detection of potentially pathogenic free-living amoebae in dental units. Can J Microbiol. 2012;58:884-6 pubmed publisher
    ..Potentially pathogenic Acanthamoeba and Naegleria spp. may be an infection risk for patients through contact with open surgical sites or aerosolization...
  59. Sukthana Y, Rigunti M, Siripanth C, Kusolsuk T, Chintrakarn C, Kulpaditharom B. An exotic sinusitis. Trans R Soc Trop Med Hyg. 2005;99:555-7 pubmed
    We report a case of sinusitis caused by mixed free-living amoebae, Acanthamoeba and Naegleria, in an immunocompetent host; this has not been documented before...
  60. Sukthana Y, Lekkla A, Sutthikornchai C, Wanapongse P, Vejjajiva A, Bovornkitti S. Spa, springs and safety. Southeast Asian J Trop Med Public Health. 2005;36 Suppl 4:10-6 pubmed
    ..Pathogenic, free-living amebae of the genera Naegleria and Acanthamoeba, which can cause central nervous system infection, were found in 26.3% (15/57) and 15...
  61. Gogarten J, Hilario E. Inteins, introns, and homing endonucleases: recent revelations about the life cycle of parasitic genetic elements. BMC Evol Biol. 2006;6:94 pubmed
    ..Two outstanding publications on the amoeba Naegleria group I intron (Wikmark et al. BMC Evol Biol 2006, 6:39) and the PRP8 inteins in ascomycetes (Butler et al...
  62. Ahmad A, Lonnen J, Andrew P, Kilvington S. Development of a rapid DNA extraction method and one-step nested PCR for the detection of Naegleria fowleri from the environment. Water Res. 2011;45:5211-7 pubmed publisher
    b>Naegleria fowleri is a small free-living amoebo-flagellate found in natural and manmade thermal aquatic habitats worldwide. The organism is pathogenic to man causing fatal primary amoebic meningoencephalitis (PAM)...
  63. Tiewcharoen S, Junnu V. Distribution of pathogenic Naegleria spp in Thailand. Southeast Asian J Trop Med Public Health. 2001;32 Suppl 2:172-8 pubmed
    Research concerning the distribution, isolation, viability, ultrastructure, morphology and immunogenicity of Naegleria fowleri has been increasing in Thailand during 1988-2000...
  64. Huang S, Hsu B. Survey of Naegleria from Taiwan recreational waters using culture enrichment combined with PCR. Acta Trop. 2011;119:114-8 pubmed publisher
    b>Naegleria is a free-living amoeba. Pathogenic Naegleria may pose a health risk to people who come in contact with recreational waters...
  65. Saburi E, Rajaii T, Behdari A, Kohansal M, Vazini H. Free-living amoebae in the water resources of Iran: a systematic review. J Parasit Dis. 2017;41:919-928 pubmed publisher
    ..i>Acanthamoeba, Naegleria, and Balamuthia are the most important FLA...
  66. Michel R, Borneff M. [The significance of amoebae and other protozoa in water conduit systems in dental units]. Zentralbl Bakteriol Mikrobiol Hyg B. 1989;187:312-23 pubmed
    ..In 96% of all water samples, one or several ameba species were detected. These included 14 strains of the genus Naegleria, but no acanthamoebae. The naeglerias isolated were not thermophilic and thus belong to the N...
  67. Rohr U, Weber S, Michel R, Selenka F, Wilhelm M. Comparison of free-living amoebae in hot water systems of hospitals with isolates from moist sanitary areas by identifying genera and determining temperature tolerance. Appl Environ Microbiol. 1998;64:1822-4 pubmed
    ..The following genera were identified: Acanthamoeba (22%), Naegleria (22%), Vahlkampfia (20%), Hartmannella (15%), and Vanella (7%)...
  68. Siripanth C, Punpoowong B, Riganti M. Early detection and identification of amphizoic amoebae from nasal exudates of a symptomatic case. J Med Assoc Thai. 2005;88:545-9 pubmed
    ..It was concluded that this patient was infected by both Naegleria spp. and Acanthamoeba spp...
  69. Wildschutte H, Lawrence J. Differential Salmonella survival against communities of intestinal amoebae. Microbiology. 2007;153:1781-9 pubmed
    ..Collections of Acanthamoeba, Tetramitus, Naegleria and Hartmannella were isolated from the intestinal tracts of several vertebrate hosts, including bullfrog ..
  70. Javanmard E, Niyyati M, Lorenzo Morales J, Lasjerdi Z, Behniafar H, Mirjalali H. Molecular identification of waterborne free living amoebae (Acanthamoeba, Naegleria and Vermamoeba) isolated from municipal drinking water and environmental sources, Semnan province, north half of Iran. Exp Parasitol. 2017;: pubmed publisher
    ..6%) were positive for outgrowth of Free living amoeba, belonging to Vermamoeba, Naegleria and Acanthamoeba using molecular tools...
  71. Waso M, Dobrowsky P, Hamilton K, Puzon G, Miller H, Khan W, et al. Abundance of Naegleria fowleri in roof-harvested rainwater tank samples from two continents. Environ Sci Pollut Res Int. 2018;25:5700-5710 pubmed publisher
    ..Therefore, this study aims to determine the quantitative occurrence of Naegleria fowleri in RHRW tank samples from Southeast Queensland (SEQ), Australia (AU), and the Kleinmond Housing Scheme ..
  72. Lekkla A, Sutthikornchai C, Bovornkitti S, Sukthana Y. Free-living ameba contamination in natural hot springs in Thailand. Southeast Asian J Trop Med Public Health. 2005;36 Suppl 4:5-9 pubmed
    Thermo tolerant free-living ameba, Naegleria spp and Acanthamoeba spp contamination in natural hot springs in Thailand were carried out from 13 provinces...
  73. Andersson J. Evolution of patchily distributed proteins shared between eukaryotes and prokaryotes: Dictyostelium as a case study. J Mol Microbiol Biotechnol. 2011;20:83-95 pubmed publisher
    ..families showed conflicts with organismal phylogenies; 25 are shared with the distantly related amoeboflagellate Naegleria (Excavata), whereas only two are present in the more closely related Entamoeba...
  74. Chomba M, Mucheleng anga L, Fwoloshi S, Ngulube J, Mutengo M. A case report: primary amoebic meningoencephalitis in a young Zambian adult. BMC Infect Dis. 2017;17:532 pubmed publisher
    Primary amoebic meningoencephalitis (PAM) is a fulminant disease of the brain caused by Naegleria fowleri. Although the disease is rare, the case fatality rate is very high. In this report, we describe the first case of PAM in Zambia...
  75. Ghanchi N, Jamil B, Khan E, Ansar Z, Samreen A, Zafar A, et al. Case Series of Naegleria fowleri Primary Ameobic Meningoencephalitis from Karachi, Pakistan. Am J Trop Med Hyg. 2017;97:1600-1602 pubmed publisher
    i>Naegleria fowleri causes primary amoebic meningoencephalitis (PAM) which is almost always fatal...
  76. Carrasco Yepez M, Campos Rodríguez R, Reséndiz Albor A, Peña Juárez C, Contis Montes de Oca A, Arciniega Martínez I, et al. Naegleria fowleri immunization modifies lymphocytes and APC of nasal mucosa. Parasite Immunol. 2017;: pubmed publisher
    ..fowleri attachment to nasal epithelium. This article is protected by copyright. All rights reserved...
  77. Michel R, Burghardt H, Bergmann H. [Acanthamoeba, naturally intracellularly infected with Pseudomonas aeruginosa, after their isolation from a microbiologically contaminated drinking water system in a hospital]. Zentralbl Hyg Umweltmed. 1995;196:532-44 pubmed
    ..growth of small freeliving amoebae in 20 samples (54%) belonging to 10 species of the genus Acanthamoeba, Naegleria, Hartmannella, Echinamoeba among others. In addition 2 Ciliate- and 2 Microflagellate-species could be observed...
  78. Dua H, Azuara Blanco A, Hossain M, Lloyd J. Non-Acanthamoeba amebic keratitis. Cornea. 1998;17:675-7 pubmed
    ..To describe the clinical presentation and outcome of two cases with presumed non-Acanthamoeba amebic keratitis...
  79. Ercken D, Verelst L, Declerck P, Duvivier L, Van Damme A, Ollevier F. Effects of peracetic acid and monochloramine on the inactivation of Naegleria lovaniensis. Water Sci Technol. 2003;47:167-71 pubmed
    Biocidal activities of monochloramine and peracetic acid were studied on cysts of Naegleria lovaniensis. Until recently the most commonly used biocide to disinfect cooling water systems was hypochlorite...
  80. Brugerolle G, Simpson A. The flagellar apparatus of heteroloboseans. J Eukaryot Microbiol. 2004;51:96-107 pubmed
    ..of four heterolobosean species Percolomonas descissus, Percolomonas sulcatus, Tetramitus rostratus, and Naegleria gruberi were examined. P. descissus lives in oxygen-poor water...
  81. Shin H, Im K. Pathogenic free-living amoebae in Korea. Korean J Parasitol. 2004;42:93-119 pubmed
    Acanthamoeba and Naegleria are widely distributed in fresh water, soil and dust throughout the world, and cause meningoencephalitis or keratoconjunctivitis in humans and other mammals. Korean isolates, namely, Naegleria sp...
  82. Oddó B D. [Infections caused by free-living amebas. Historical commentaries, taxonomy and nomenclature, protozoology and clinicopathologic features]. Rev Chilena Infectol. 2006;23:200-14 pubmed
  83. Ramirez E, Robles E, Martinez B. Free-living amoebae isolated from water-hyacinth root (Eichhornia crassipes). Exp Parasitol. 2010;126:42-4 pubmed publisher
    ..The most frequent were Vannella in root and Acanthamoeba and Naegleria in water. The total number of isolates and genera isolated from root was higher than that isolated from water...
  84. Ravine T, Polski J, Jenkins J. Recognition of Naegleriae ameba surface protein epitopes by anti-human CD45 antibodies. Cytometry A. 2010;77:305-9 pubmed publisher
    ..In this study, we incubated Naegleria and Acanthamoeba amebas with several directly conjugated anti-human leukocyte monoclonal antibodies (mAb) for ..
  85. Teixeira L, Rocha S, Pinto R, Caseiro M, Costa S. Prevalence of potentially pathogenic free-living amoebae from Acanthamoeba and Naegleria genera in non-hospital, public, internal environments from the city of Santos, Brazil. Braz J Infect Dis. 2009;13:395-7 pubmed
    Acanthamoeba and Naegleria species are free-living amoebae (FLA) found in a large variety of natural habitats...
  86. Walsh C. The structure of the mitotic spindle and nucleolus during mitosis in the amebo-flagellate Naegleria. PLoS ONE. 2012;7:e34763 pubmed publisher
    Mitosis in the amebo-flagellate Naegleria pringsheimi is acentrosomal and closed (the nuclear membrane does not break down). The large central nucleolus, which occupies about 20% of the nuclear volume, persists throughout the cell cycle...
  87. Yadav D, Aneja S, Dutta R, Maheshwari A, Seth A. Youngest survivor of naegleria meningitis. Indian J Pediatr. 2013;80:253-4 pubmed publisher
    ..The authors report a 25-d-old boy, the youngest survivor of Naegleria meningitis. The child was admitted with a diagnosis of partially treated meningitis...
  88. Baek I, Chung S, Suh M, Hwang D, Kang D, Lee J. Coordinate synthesis but discrete localization of homologous N-glycosylated proteins, CLP and CLB, in Naegleria pringsheimi flagellates. J Eukaryot Microbiol. 2012;59:614-24 pubmed publisher
    The synchronous amoebae-to-flagellates differentiation of Naegleria pringsheimi has been used as a model system to study the formation of eukaryotic flagella...
  89. Yousuf F, Siddiqui R, Khan N. Presence of rotavirus and free-living amoebae in the water supplies of Karachi, Pakistan. Rev Inst Med Trop Sao Paulo. 2017;59:e32 pubmed publisher
    ..Balamuthia mandrillaris, Naegleria fowleri) in drinking water supplies of Karachi, Pakistan...
  90. Vernhes M, Benichou A, Pernin P, Cabanes P, Teissie J. Elimination of free-living amoebae in fresh water with pulsed electric fields. Water Res. 2002;36:3429-38 pubmed
    This study investigates the effects of pulsed electric fields on the inactivation of trophozoite form of Naegleria lovaniensis Ar9M-1 in batch and flow processes, systematically examining the lethal effect of field strength, pulse ..
  91. Tiewcharoen S, Junnu V, Suvoutho S. Effect of antifungal drugs on pathogenic Naegleria spp isolated from natural water sources. J Med Assoc Thai. 2003;86:876-82 pubmed
    Five of 16 strains of pathogenic Naegleria spp isolated from 350 natural water sources in Taling Chan District, Bangkok had similar molecular weights and zymogram patterns to those of Naegleria fowleri CDCVO 3081 and Thai strain...
  92. Izumiyama S, Yagita K, Furushima Shimogawara R, Asakura T, Karasudani T, Endo T. Occurrence and distribution of Naegleria species in thermal waters in Japan. J Eukaryot Microbiol. 2003;50 Suppl:514-5 pubmed